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Aliases for ZBTB3 Gene

Aliases for ZBTB3 Gene

  • Zinc Finger And BTB Domain Containing 3 2 3 5

External Ids for ZBTB3 Gene

Previous GeneCards Identifiers for ZBTB3 Gene

  • GC11M062766
  • GC11M062293
  • GC11M062275
  • GC11M061931
  • GC11M062518
  • GC11M058847

Summaries for ZBTB3 Gene

GeneCards Summary for ZBTB3 Gene

ZBTB3 (Zinc Finger And BTB Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB3 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB3 Gene

Genomics for ZBTB3 Gene

Regulatory Elements for ZBTB3 Gene

Promoters for ZBTB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB3 Gene

62,748,319 bp from pter
62,754,188 bp from pter
5,870 bases
Minus strand

Genomic View for ZBTB3 Gene

Genes around ZBTB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB3 Gene

Proteins for ZBTB3 Gene

  • Protein details for ZBTB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 3
    Protein Accession:

    Protein attributes for ZBTB3 Gene

    574 amino acids
    Molecular mass:
    61827 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB3 Gene

Proteomics data for ZBTB3 Gene at MOPED

Post-translational modifications for ZBTB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZBTB3 Gene

Domains & Families for ZBTB3 Gene

Gene Families for ZBTB3 Gene

Protein Domains for ZBTB3 Gene

Suggested Antigen Peptide Sequences for ZBTB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB3: view

Function for ZBTB3 Gene

Molecular function for ZBTB3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZBTB3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB3 Gene

Localization for ZBTB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB3 Gene

Subcellular locations from

Jensen Localization Image for ZBTB3 Gene COMPARTMENTS Subcellular localization image for ZBTB3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZBTB3 Gene

Pathways & Interactions for ZBTB3 Gene

SuperPathways for ZBTB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZBTB3 Gene

Drugs & Compounds for ZBTB3 Gene

No Compound Related Data Available

Transcripts for ZBTB3 Gene

mRNA/cDNA for ZBTB3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB3 Gene

Zinc finger and BTB domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB3 Gene

No ASD Table

Relevant External Links for ZBTB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB3 Gene

mRNA expression in normal human tissues for ZBTB3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB3 Gene

SOURCE GeneReport for Unigene cluster for ZBTB3 Gene Hs.147554

genes like me logo Genes that share expression patterns with ZBTB3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZBTB3 Gene

Orthologs for ZBTB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZBTB3 35
  • 89.06 (n)
  • 88.93 (a)
ZBTB3 36
  • 88 (a)
(Canis familiaris)
Mammalia ZBTB3 35
  • 88.56 (n)
  • 87.91 (a)
ZBTB3 36
  • 85 (a)
(Mus musculus)
Mammalia Zbtb3 35
  • 86.63 (n)
  • 84.5 (a)
Zbtb3 16
Zbtb3 36
  • 84 (a)
(Pan troglodytes)
Mammalia ZBTB3 35
  • 99.42 (n)
  • 99.48 (a)
ZBTB3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zbtb3 35
  • 86.54 (n)
  • 84.85 (a)
(Monodelphis domestica)
Mammalia ZBTB3 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB3 36
  • 72 (a)
(Danio rerio)
Actinopterygii LOC100536022 35
  • 54.06 (n)
  • 48.26 (a)
FP074862.4 36
  • 40 (a)
zbtb3 36
  • 37 (a)
Species with no ortholog for ZBTB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB3 Gene

Gene Tree for ZBTB3 (if available)
Gene Tree for ZBTB3 (if available)

Paralogs for ZBTB3 Gene

genes like me logo Genes that share paralogs with ZBTB3: view

Variants for ZBTB3 Gene

Sequence variations from dbSNP and Humsavar for ZBTB3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs544641 - 62,752,093(-) AACAT(C/G/T)TAAGG reference, missense
VAR_035600 A breast cancer sample
VAR_035601 A breast cancer sample
rs491333 -- 62,752,221(-) GCAGC(A/C)AACCA reference, missense
rs491634 -- 62,755,940(-) catgt(G/T)ggtca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBTB3 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv348 CNV Loss 18451855
nsv483055 CNV Loss 15286789

Variation tolerance for ZBTB3 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB3 Gene

Disorders for ZBTB3 Gene

Relevant External Links for ZBTB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZBTB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB3 Gene

Publications for ZBTB3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells. (PMID: 24856827) Lim J.H. (BMB Rep 2014) 3
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZBTB3 Gene

Sources for ZBTB3 Gene

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