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ZBTB3 Gene

protein-coding GIFtS: 49

GC11M062275

zinc finger and BTB domain containing 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ23392 ^¹, ²

Descriptions
zinc finger and BTB domain containing 3 ^²

External Ids
HGNC: 22918¹
Entrez Gene: 79842²
UniProtKB: Q9H5J0³
Ensembl: ENSG00000185670⁷

Search outside databases for aliases for ZBTB3 gene

Previous GC identifers: GC11M062766 GC11M062293 GC11M061931

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBTB3_HUMAN, Q9H5J0

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB3 gene

Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.3

ZBTB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M062275: (about GC identifiers)

Start:	62,241,807 bp from pter
End:	62,278,190 bp from pter
Size:	36,384 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBTB3_HUMAN, Q9H5J0 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 3

Size: 574 amino acids; 61827 Da

Subcellular location: Nucleus (Potential)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079060.1

ENSEMBL proteins:

ENSP00000331926 ENSP00000378286

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZBTB3)
	Human Recombinant Proteins from Abnova (ZBTB3)

OriGene Purified Recombinant Human Protein: ZBTB3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for ZBTB3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZBTB3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBTB3)
	Novus Biologicals Antibodies for ZBTB3

Assays for ZBTB3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H5J0

ProtoNet protein and cluster: Q9H5J0

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBTB3_HUMAN, Q9H5J0

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 2 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024784

Applied Biosystems Silencer® siRNAs for ZBTB3

Sigma-Aldrich siRNA and siRNA Panels for ZBTB3

Sigma-Aldrich shRNA for ZBTB3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024784
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024784
untagged cDNA clones in CMV expression vector (see all 2): NM_024784

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024784

UniProtKB/Swiss-Prot: ZBTB3_HUMAN, Q9H5J0

Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for ZBTB3 (Q9H5J0²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
SKIL P12757² MINT-61668
About this table
2 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006350 transcription IEA --
GO:0006355 regulation of transcription, DNA-dependent IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024784

Sigma-Aldrich siRNA and siRNA Panels for ZBTB3

Sigma-Aldrich shRNA for ZBTB3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024784

REFSEQ mRNAs for ZBTB3 gene:

NM_024784.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024784

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024784
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024784
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_024784

Additional cDNA sequence: BC025249.1

3 DOTS entries:

DT.99955486 DT.40237474 DT.120742450

15 AceView cDNA sequences:

BC025249 NM_024784 AI290230 BG259363 AI393202 BP377169 R47379 AK027045

AI217048 AI376699 BM844478 CB047577 BM915160 BF326710 CA748869

highest scoring ESTs for ZBTB3:

AI393202 BC025249 BM915160 AK027045 BG259363 BM009744 BM844478 BP377169 NM_024784 R47379

Unigene Cluster for ZBTB3:

Zinc finger and BTB domain containing 3

Hs.147554 [show with all ESTs]

Unigene Representative Sequence: NM_024784

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000329958 ENST00000394807

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB3

¹ / ² / ³

6 probe-sets matching ZBTB3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
67302_at²^{, 3}	U95-D	1	1.00	1.00	0.57	0.82	AI393202	0.80	1.00	0.91	1
62348_at²^{, 3}	U95-C	1	1.00	1.00	0.73	0.53	AI290230	0.40	1.00	0.76	1
56258_f_at²^{, 3}	U95-C	2643	0.56	0.00	0.12	1.67	AI370094	0.20	0.09	0.16	1
220391_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024784	0.60	1.00	0.82	1
1553858_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220391_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZBTB3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCAGCCTCC

SOURCE GeneReport for Unigene cluster: Hs.147554

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB3 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB3¹	--	zinc finger and BTB domain containing 3	88.09(n) 86.28(a)	483781 XM_849933.1 XP_855026.1
chimpanzee (Pan troglodytes)	ZBTB3¹	--	zinc finger and BTB domain containing 3	99.53(n) 99.65(a)	466639 XM_522038.2 XP_522038.2
rat (Rattus norvegicus)	Zbtb3¹	--	zinc finger and BTB domain containing 3	86.58(n) 85.02(a)	499313 XM_574614.2 XP_574614.2
mouse (Mus musculus)	Zbtb3^{1, 5}	19⁵	zinc finger and BTB domain containing 3^{1, 5}	86.67(n)¹ 84.66(a)¹	75291¹ NM_133759.2¹ NP_598520.1¹ AI428344⁵ AK016209⁵ (see all 12)
zebrafish (Danio rerio)	LOC100003975¹	--	similar to zinc finger and BTB domain containing 3	54.01(n) 47.85(a)	100003975 XM_001343364.2 XP_001343400.1

About this table Species with no ortholog for ZBTB3

ENSEMBL Gene Tree for ZBTB3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB3 gene

ZNF238² ZNF509² ZBTB17²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/28 NCBI SNPs in ZBTB3 are shown (see all 28 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs544641^1,2	A,C,F,H	62276141(-)	`AACATC/GTAAGG`	1	I/M	mis¹ ese³		17		NS MN EU EA WA NA	1262
	rs3829248^1,2	F,H	62278239(-)	`CTTAAG/ACCAAT`	1	--	ng3¹		3		EU EA	298
	rs2873105^1,2	H	62278399(-)	`GCAAGG/AAAGGC`	1	--	ng3¹		4		EU EA WA	418
--	rs2510075^1,2	A	62280135(-)	`TGCAAC/TGGCAC`	1	--	ng3¹		0	--	--	--	--
--	rs11231200^1,2	A	62274705(+)	`cgggcA/Ggatca`	1	--	ng5¹		0	--	--	--	--
	rs572513^1,2	C,F,H	62277832(-)	`GGCAAG/ATGATA`	1	--	int¹		7		MN EU EA NA	620
--	rs60399633^1,2	--	62274612(+)	`ACCCC-/TACCCC AAGTA`	1	--	ng5¹		0	--	--	--	--
--	rs7945873^1,2	--	62275439(+)	`gaggtC/Taggag`	1	--	ut3¹		0	--	--	--	--
--	rs566749^1,2	--	62275678(+)	`gactcA/Caaaaa`	1	--	ut3¹		0	--	--	--	--
--	rs11231201^1,2	--	62275811(+)	`CCCTGC/TCTCTA`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ZBTB3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for ZBTB3 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)⁴ Sjoeblom T.... Velculescu V.E. (2006)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)³ Colland F....Gauthier J.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 79842	HGNC: 22918	AceView: ZBTB3	Ensembl:ENSG00000185670	euGenes: HUgn79842
ECgene: ZBTB3	H-InvDB: ZBTB3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB3		Antibodies for ZBTB3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBTB3)
	Antibodies (ZBTB3)
	Chimera RNAi (ZBTB3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ZBTB3)
	Antibodies (ZBTB3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ZBTB3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ZBTB3

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ZBTB3 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for ZBTB3

Summaries
for ZBTB3

Genomic Location
for ZBTB3

Proteins
for ZBTB3

Protein Domains/
Families
for ZBTB3

Gene Function
for ZBTB3

Pathways & Interactions
for ZBTB3

Drugs & Compounds
for ZBTB3

Transcripts
for ZBTB3

Expression
for ZBTB3

Orthologs
for ZBTB3

Paralogs
for ZBTB3

SNPs/Variants
for ZBTB3

Disorders & Mutations
for ZBTB3

Medical News
for ZBTB3

Publications
for ZBTB3

Search for ZBTB3

Genome Databases showing ZBTB3

Other Databases showing ZBTB3

Specialized Databases showing ZBTB3

Licensable Technologies
for ZBTB3

Services
for ZBTB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB3 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor ZBTB3

Summariesfor ZBTB3

Genomic Locationfor ZBTB3

Proteinsfor ZBTB3

Protein Domains/Familiesfor ZBTB3

Gene Functionfor ZBTB3

Pathways & Interactionsfor ZBTB3

Drugs & Compoundsfor ZBTB3

Transcriptsfor ZBTB3

Expression for ZBTB3

Orthologsfor ZBTB3

Paralogsfor ZBTB3

SNPs/Variantsfor ZBTB3

Disorders & Mutationsfor ZBTB3

Medical Newsfor ZBTB3

Publicationsfor ZBTB3

Search for ZBTB3

Genome Databases showing ZBTB3

Other Databases showing ZBTB3

Specialized Databases showing ZBTB3

Licensable Technologiesfor ZBTB3

Servicesfor ZBTB3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB3

Summaries
for ZBTB3

Genomic Location
for ZBTB3

Proteins
for ZBTB3

Protein Domains/
Families
for ZBTB3

Gene Function
for ZBTB3

Pathways & Interactions
for ZBTB3

Drugs & Compounds
for ZBTB3

Transcripts
for ZBTB3

Expression
for ZBTB3

Orthologs
for ZBTB3

Paralogs
for ZBTB3

SNPs/Variants
for ZBTB3

Disorders & Mutations
for ZBTB3

Medical News
for ZBTB3

Publications
for ZBTB3

Licensable Technologies
for ZBTB3

Services
for ZBTB3