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Aliases for ZBTB3 Gene

Aliases for ZBTB3 Gene

  • Zinc Finger And BTB Domain Containing 3 2 3 5

External Ids for ZBTB3 Gene

Previous GeneCards Identifiers for ZBTB3 Gene

  • GC11M062766
  • GC11M062293
  • GC11M062275
  • GC11M061931
  • GC11M062518
  • GC11M058847

Summaries for ZBTB3 Gene

GeneCards Summary for ZBTB3 Gene

ZBTB3 (Zinc Finger And BTB Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is ZBTB18.

UniProtKB/Swiss-Prot for ZBTB3 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB3 Gene

Genomics for ZBTB3 Gene

Regulatory Elements for ZBTB3 Gene

Enhancers for ZBTB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G062752 1.1 ENCODE 0.7 +0.4 376 2.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 ZNF207 TTC9C IMMP1LP1 UBXN1 EEF1G METTL12 LRRN4CL PIR44039 ZBTB3
GH11G062757 0.7 ENCODE 0.7 -4.2 -4189 2.5 SOX13 HLF CEBPB ZNF384 RBBP5 CHD7 ETS1 HDAC2 ZNF366 POLR2A TTC9C ZBTB3 POLR2G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB3 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040470 -12 1201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 FOS

Genomic Location for ZBTB3 Gene

Chromosome:
11
Start:
62,748,319 bp from pter
End:
62,754,188 bp from pter
Size:
5,870 bases
Orientation:
Minus strand

Genomic View for ZBTB3 Gene

Genes around ZBTB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB3 Gene

Proteins for ZBTB3 Gene

  • Protein details for ZBTB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5J0-ZBTB3_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 3
    Protein Accession:
    Q9H5J0

    Protein attributes for ZBTB3 Gene

    Size:
    574 amino acids
    Molecular mass:
    61827 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB3 Gene

Post-translational modifications for ZBTB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB3 Gene

No data available for DME Specific Peptides for ZBTB3 Gene

Domains & Families for ZBTB3 Gene

Gene Families for ZBTB3 Gene

Protein Domains for ZBTB3 Gene

Suggested Antigen Peptide Sequences for ZBTB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB3: view

No data available for UniProtKB/Swiss-Prot for ZBTB3 Gene

Function for ZBTB3 Gene

Molecular function for ZBTB3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB3: view
genes like me logo Genes that share phenotypes with ZBTB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB3 Gene

Localization for ZBTB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB3: view

Pathways & Interactions for ZBTB3 Gene

SuperPathways for ZBTB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB3: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB3 Gene

Drugs & Compounds for ZBTB3 Gene

No Compound Related Data Available

Transcripts for ZBTB3 Gene

mRNA/cDNA for ZBTB3 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB3 Gene

Zinc finger and BTB domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB3 Gene

No ASD Table

Relevant External Links for ZBTB3 Gene

GeneLoc Exon Structure for
ZBTB3
ECgene alternative splicing isoforms for
ZBTB3

Expression for ZBTB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB3 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB3 Gene:

ZBTB3

SOURCE GeneReport for Unigene cluster for ZBTB3 Gene:

Hs.147554

Evidence on tissue expression from TISSUES for ZBTB3 Gene

  • Liver(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with ZBTB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB3 Gene

Orthologs for ZBTB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB3 34 35
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia ZBTB3 34 35
  • 89.06 (n)
dog
(Canis familiaris)
Mammalia ZBTB3 34 35
  • 88.56 (n)
mouse
(Mus musculus)
Mammalia Zbtb3 34 16 35
  • 86.63 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb3 34
  • 86.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB3 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB3 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zbtb3 34 35
  • 54.06 (n)
FP074862.4 35
  • 40 (a)
OneToMany
Species where no ortholog for ZBTB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB3 Gene

ENSEMBL:
Gene Tree for ZBTB3 (if available)
TreeFam:
Gene Tree for ZBTB3 (if available)

Paralogs for ZBTB3 Gene

Variants for ZBTB3 Gene

Sequence variations from dbSNP and Humsavar for ZBTB3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_035600 A breast cancer sample
VAR_035601 A breast cancer sample
rs1000289029 -- 62,752,162(+) TCTGC(C/T)GTTGG reference, synonymous-codon
rs1000681755 -- 62,752,487(+) CGGGT(C/G)CAGGC reference, missense
rs1000932774 -- 62,750,633(+) TCCCA(A/G)CACTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZBTB3 Gene

Variant ID Type Subtype PubMed ID
nsv348 CNV deletion 18451855

Variation tolerance for ZBTB3 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB3 Gene

Disorders for ZBTB3 Gene

Relevant External Links for ZBTB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB3

No disorders were found for ZBTB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB3 Gene

Publications for ZBTB3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier R.A. … Vermeulen M. (J. Biol. Chem. 2016) 3 64
  4. Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells. (PMID: 24856827) Lim J.H. (BMB Rep 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for ZBTB3 Gene

Sources for ZBTB3 Gene

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