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ZBTB26 Gene

protein-coding GIFtS: 49

GC09M124717

zinc finger and BTB domain containing 26
(Previous name: zinc finger protein 481 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF481)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA1572 ^², ³
OTTHUMP00000022072 ^²
OTTHUMP00000022073 ^²
ZNF481 ^², ³
bioref ^²

Descriptions
Zinc finger protein 481 ^¹, ², ³
Zinc finger protein Bioref ^³
zinc finger and BTB domain containing 26 ^²
zinc finger protein 483 ^²

External Ids
HGNC: 23383¹
Entrez Gene: 57684²
UniProtKB: Q9HCK0³
Ensembl: ENSG00000171448⁷

Search outside databases for aliases for ZBTB26 gene

Previous GC identifers: GC09M121057 GC09M122759

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT26_HUMAN, Q9HCK0

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB26 gene

Entrez Gene cytogenetic band: 9q33.2 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q34.11

ZBTB26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M124717: (about GC identifiers)

Start:	124,720,199 bp from pter
End:	124,733,600 bp from pter
Size:	13,402 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT26_HUMAN, Q9HCK0 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 26

Size: 441 amino acids; 49953 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B3KQ53 Q8WTR1

REFSEQ proteins: NP_065975.1

ENSEMBL proteins:

ENSP00000362758 ENSP00000362760

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZBTB26)
	Human Recombinant Proteins from Abnova (ZBTB26)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

Antibodies for ZBTB26:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB26
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZBTB26), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBTB26)
	Novus Biologicals Antibodies for ZBTB26

Assays for ZBTB26:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9HCK0

ProtoNet protein and cluster: Q9HCK0

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBT26_HUMAN, Q9HCK0

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 4 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB26)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB26)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020924

Applied Biosystems Silencer® siRNAs for ZBTB26

Sigma-Aldrich siRNA and siRNA Panels for ZBTB26

Sigma-Aldrich shRNA for ZBTB26

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB26
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020924
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020924
untagged cDNA clone in CMV expression vector: NM_020924

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020924

UniProtKB/Swiss-Prot: ZBT26_HUMAN, Q9HCK0

Function: May be involved in transcriptional regulation

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008150	biological_process	ND	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB26

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB26)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB26)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020924

Sigma-Aldrich siRNA and siRNA Panels for ZBTB26

Sigma-Aldrich shRNA for ZBTB26

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020924

REFSEQ mRNAs for ZBTB26 gene:

NM_020924.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020924

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020924
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020924
                                 untagged cDNA clone in CMV expression vector: NM_020924

Additional cDNA sequence:

AB046792.1 AF323460.2 AK057445.1 AK058083.1 BC018748.1 CR625966.1

4 DOTS entries:

DT.100740613 DT.309625 DT.99949423 DT.121161504

24/74 AceView cDNA sequences (see all 74 ):

BM919361 AK057445 CR625966 BE243031 AF323460 BC018748 BX954351 AB046792

AI962962 BX089640 BM697387 NM_020924 BU187201 AI924135 AI582359 BX353173

BU155060 AK058083 AI752862 BX954890 BP369284 BU599195 BM799945 AA971971

highest scoring ESTs for ZBTB26:

AI017087 AI582359 BC018748 BG338451 BI825189 BM919361 BX506163 AA190234 AA285382 AA559151

Unigene Cluster for ZBTB26:

Zinc finger and BTB domain containing 26

Hs.5638 [show with all ESTs]

Unigene Representative Sequence: AB046792

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB26

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d
SP1:							-
SP2:							-		-
SP3:							-		-
SP4:									-

About this scheme

ECgene alternative splicing isoforms for ZBTB26

2 Ensembl transcripts including schematic representations:

ENST00000373654 ENST00000373656

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB26 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB26

¹ / ² / ³

5 probe-sets matching ZBTB26 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90379_at²^{, 3}	U95-D	1	1.00	1.00	0.96	0.97	AI017087	0.80	1.00	0.91	1
50153_at²^{, 3}	U95-C	1	1.00	1.00	0.79	1.04	AI582359	0.80	1.00	0.91	1
227162_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF214688	0.60	1.00	0.82	1
227162_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554973_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZBTB26 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: AATAGCTGTT

SOURCE GeneReport for Unigene cluster: Hs.5638
UniProtKB/Swiss-Prot: ZBT26_HUMAN, Q9HCK0
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB26 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB26¹	--	zinc finger and BTB domain containing 26	97.51(n) 100(a)	491342 XM_548463.2 XP_548463.2
chimpanzee (Pan troglodytes)	ZBTB26¹	--	zinc finger and BTB domain containing 26	100(n) 100(a)	464716 XM_520241.2 XP_520241.2
cow (Bos taurus)	ZBTB26¹	--	zinc finger and BTB domain containing 26	96.22(n) 99.09(a)	540217 XM_592371.3 XP_592371.3
rat (Rattus norvegicus)	Zbtb26¹	--	zinc finger and BTB domain containing 26	95.61(n) 96.14(a)	311910 XM_231250.4 XP_231250.4
mouse (Mus musculus)	Zbtb26^{1, 5}	2⁵	zinc finger and BTB domain containing 26^{1, 5}	95.45(n)¹ 95.91(a)¹	320633¹ NM_199025.2¹ NP_950190.2¹ AK041637⁵ AK044592⁵ (see all 12)

About this table Species with no ortholog for ZBTB26

ENSEMBL Gene Tree for ZBTB26

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB26 gene

ZBTB6² ZBTB12² ENSG00000180610²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/61 NCBI SNPs in ZBTB26 are shown (see all 61 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 43)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2241064^1,2	A,C,F,H,O	124720368(-)	`ATAACG/ATCACC`	1	--	ut3¹ ese³		11	EU EA WA NA	976
	rs1868589^1,2	C,F,H	124734522(-)	`GAAATT/GTATAG`	1	--	ng3¹		8	EU EA WA	834
	rs7856488^1,2	C,H	124721328(+)	`GGAGAT/CGGTTT`	1	R/H	mis¹		4	EU EA WA	418
--	rs1868590^1,2	A,H	124734431(-)	`ggaggT/Gtggat`	1	--	ng3¹		4	EU EA WA	410
	rs4370606^1,2	H	124721917(+)	`ATCATC/ATATGA`	1	Y/D	mis¹		4	EU EA WA	418
	rs7470145^1,2	H	124722005(+)	`AACTTG/AAAGTG`	1	F/F	syn¹ ese³		4	EU EA WA	408
	rs2539926^1,2	A,C,F,H,O	124722942(-)	`TAATGA/TTTGAT`	1	--	int¹		7	NA EU EA WA	550
	rs2539924^1,2	A,C,F,O	124729695(-)	`GAAAGC/GCTGTA`	1	--	int¹ trp³		3	NA	142
	rs3824535^1,2	A,C,F,H	124723677(-)	`GTATCA/CGGCAT`	1	--	int¹		7	EU EA WA NA	560
	rs3739836^1,2	A,C,F,H	124723336(-)	`CTTTTT/CCCTTG`	1	--	int¹ trp³		8	EA EU WA NA	1296

About this table

HapMap Linkage Disequilibrium images for ZBTB26 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for ZBTB26 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{3, 4} Nagase T....Ohara O. (2000)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57684	HGNC: 23383	AceView: ZBTB26	Ensembl:ENSG00000171448	euGenes: HUgn57684
ECgene: ZBTB26	H-InvDB: ZBTB26

(According to HUGE)
About This Section

HUGE: KIAA1572

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB26
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB26:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB26-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB26		Antibodies for ZBTB26
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB26		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBTB26)
	Antibodies (ZBTB26)
	Chimera RNAi (ZBTB26)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (ZBTB26)

Search OriGene for ZBTB26

Search Tocris compounds for ZBTB26

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ZBTB26

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ZBTB26 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for ZBTB26

Summaries
for ZBTB26

Genomic Location
for ZBTB26

Proteins
for ZBTB26

Protein Domains/
Families
for ZBTB26

Gene Function
for ZBTB26

Pathways & Interactions
for ZBTB26

Drugs & Compounds
for ZBTB26

Transcripts
for ZBTB26

Expression
for ZBTB26

Orthologs
for ZBTB26

Paralogs
for ZBTB26

SNPs/Variants
for ZBTB26

Disorders & Mutations
for ZBTB26

Medical News
for ZBTB26

Publications
for ZBTB26

Search for ZBTB26

Genome Databases showing ZBTB26

Other Databases showing ZBTB26

Specialized Databases showing ZBTB26

Licensable Technologies
for ZBTB26

Services
for ZBTB26

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB26 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor ZBTB26

Summariesfor ZBTB26

Genomic Locationfor ZBTB26

Proteinsfor ZBTB26

Protein Domains/Familiesfor ZBTB26

Gene Functionfor ZBTB26

Pathways & Interactionsfor ZBTB26

Drugs & Compoundsfor ZBTB26

Transcriptsfor ZBTB26

Expression for ZBTB26

Orthologsfor ZBTB26

Paralogsfor ZBTB26

SNPs/Variantsfor ZBTB26

Disorders & Mutationsfor ZBTB26

Medical Newsfor ZBTB26

Publicationsfor ZBTB26

Search for ZBTB26

Genome Databases showing ZBTB26

Other Databases showing ZBTB26

Specialized Databases showing ZBTB26

Licensable Technologiesfor ZBTB26

Servicesfor ZBTB26

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB26

Summaries
for ZBTB26

Genomic Location
for ZBTB26

Proteins
for ZBTB26

Protein Domains/
Families
for ZBTB26

Gene Function
for ZBTB26

Pathways & Interactions
for ZBTB26

Drugs & Compounds
for ZBTB26

Transcripts
for ZBTB26

Expression
for ZBTB26

Orthologs
for ZBTB26

Paralogs
for ZBTB26

SNPs/Variants
for ZBTB26

Disorders & Mutations
for ZBTB26

Medical News
for ZBTB26

Publications
for ZBTB26

Licensable Technologies
for ZBTB26

Services
for ZBTB26