ZBTB25 Gene
protein-coding GIFtS: 48
GCID: GC14M064953
|
|
zinc finger and BTB domain containing 25(Previous names: zinc finger protein 46 (KUP), chromosome 14 open reading...)
(Previous symbols: ZNF46, C14orf51)
| |
Aliases
for ZBTB25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 251 2 | | Zinc Finger Protein KUP2 3 | | KUP1 2 3 5 | | Chromosome 14 Open Reading Frame 511 | | ZNF461 2 3 5 | | Zinc Finger Protein 46 (KUP)1 | | C14orf511 2 3 | | Zinc Finger And BTB Domain-Containing Protein 252 | | Zinc Finger Protein 462 3 | | |
Export aliases for ZBTB25 gene to outside databasesPrevious GC identifers: GC14M064024 GC14M045126 |
Summaries
for ZBTB25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB25 gene promoter:
E2F-4 E2F-3a E2F-5 p53 E2F-2 GATA-2 MEF-2A POU2F1 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q23-q24 Ensembl cytogenetic band: 14q23.3 HGNC cytogenetic band: 14q23-q24ZBTB25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M064953: view genomic region
(about GC identifiers)
Start:
|
64,915,824 bp from pter |
End:
|
64,971,931 bp from pter |
Size:
|
56,108 bases |
Orientation:
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minus strand |
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Proteins
for ZBTB25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 25 Size: 435 amino acids; 48990 Da
Subcellular location: Nucleus
Secondary accessions: B3KUX6 Q8IYH9Explore the universe of human proteins at neXtProt for ZBTB25: NX_P24278
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P24278
ZBTB25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008908.2
ENSEMBL proteins: ENSP00000450718 ENSP00000451046 ENSP00000261683 ENSP00000378204
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZBTB25 for ontologies About GeneDecksing
ZBTB25 Antibody Products:
Assay Products for ZBTB25: |
Protein
Domains /
Families
for ZBTB25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB25 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P24278ProtoNet protein and cluster: P24278 2 Blocks protein families: IPB000210 BTB/POZ domain IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 2 C2H2-type zinc fingers |
Function
for ZBTB25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB25 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB25 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZBTB25 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZBTB25:
|
Pathways & Interactions
for ZBTB25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB25
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/21 Interacting proteins for ZBTB25 (P242781, 2, 3 ENSP000002616834) via UniProtKB, MINT, STRING, and/or I2D (see all 21)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| MAPK9 | P459842, 3, ENSP000003214104 | MINT-66910 I2D:
score=5 STRING: ENSP00000321410 | | COIL | P384322, 3, ENSP000002403164 | MINT-2864246 I2D:
score=3 STRING: ENSP00000240316 | | MDFI | Q997501, 2, 3, ENSP000002303214 | EBI-739899,EBI-724076 MINT-66714 I2D:
score=6 STRING: ENSP00000230321 | | KXD1 | Q9BQD32, 3, ENSP000002223074 | MINT-67241 I2D:
score=4 STRING: ENSP00000222307 | | SORBS3 | O605043, ENSP000002401234 | I2D:
score=5 STRING: ENSP00000240123 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ZBTB25 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB25
Search CenterWatch for drugs/clinical trials and news about ZBTB25 / ZBT25
|
Transcripts
for ZBTB25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB25 gene: NM_006977.2 Unigene Cluster for ZBTB25: Zinc finger and BTB domain containing 25 Hs.654571 [show with all ESTs]Unigene Representative Sequence: AK0981814 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555220(uc001xhc.3) ENST00000555424 ENST00000261683(uc001xhf.3)
ENST00000394715(uc001xhg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB25 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB25
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB25 (NM_006977) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB25 |
Additional cDNA sequence: AK098181.1 AK313889.1 BC035804.1 X16576.1 3 DOTS entries: DT.75104387 DT.120751954 DT.40283744 24 AceView cDNA sequences: AI282142 AI768653 BX094827 BC035804 CB138430 NM_006977 BQ446833 BQ446864 AK098181 X16576 AI984553 BG025956 BU603554 BM546773 AI802967 BM727842 AL598866 AW449363 BX479957 BV196384 BG214864 BM550005 BG327685 AI435898
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB25 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for ZBTB25
|
Expression
for ZBTB25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATACACACA
About this image
See ZBTB25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB25
SOURCE GeneReport for Unigene cluster: Hs.654571
UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278Tissue specificity: Expressed mainly in hematopoietic cells and testis
SABiosciences Custom PCR Arrays for ZBTB25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB25 |
Orthologs
for ZBTB25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB25 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZBTB251 |
zinc finger and BTB domain containing 25 |
67.21(n)
68.69(a) |
|
423505 XM_421407.3 XP_421407.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB256 |
-- |
71(a) |
1 ↔ 1 |
1(1416570-1419422) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.193262 |
Transcribed sequence with weak similarity to protein more |
75.88(n) |
|
AL849602.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
zbtb251 |
zinc finger and BTB domain containing 25 |
50.56(n)
45.69(a) |
|
567401 XM_690696.1 XP_695788.1 |
ENSEMBL Gene Tree for ZBTB25 (if available)
TreeFam Gene Tree for ZBTB25 (if available) |
Paralogs
for ZBTB25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB25 gene
- ZBTB22 ZBTB12
18/26 SIMAP similar genes for ZBTB25 using alignment to 3 protein entries: ZBT25_HUMAN (see all proteins)
(see all similar genes):ZBTB17 ZBTB4 ZBTB7C ZBTB1 MYNN KLHL32
ZBTB49 ZBTB10 ZBTB20 HIC1 ZBTB14 KLHL28
ZNF131 ZBTB38 ZNF630 BACH2 BACH1 KLHL36
ZBTB25 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB25 (64915824 - 64971931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB25: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB25 |
|
Disorders
/ Diseases
for ZBTB25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB25 for disorders About GeneDecksing
OMIM gene information: 194541
OMIM disorders: --
1  disease for ZBTB25: About MalaCardsataxia
Export disorders for ZBTB25 gene to outside databases
|
Publications
for ZBTB25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB25 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. (PubMed id 2027750)1, 2 Chardin P.... Gisselbrecht S. (1991)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Gene enrichment profiles reveal T-cell development, d ifferentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. (PubMed id 20410506)1 Benita Y....Xavier R.J. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (2009)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZBTB25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB25 gene:
Search GeneIP for patents involving ZBTB25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Search Tocris compounds for ZBTB25 |
| |  |  |  |  | | | | |
 |
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 |
 | | | ZBTB25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB25 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB25 |
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