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Aliases for ZBTB25 Gene

Aliases for ZBTB25 Gene

  • Zinc Finger And BTB Domain Containing 25 2 3 5
  • Zinc Finger Protein KUP 3 4
  • Zinc Finger Protein 46 3 4
  • C14orf51 3 4
  • ZNF46 3 4
  • KUP 3 4
  • Zinc Finger And BTB Domain-Containing Protein 25 3
  • Chromosome 14 Open Reading Frame 51 2
  • Zinc Finger Protein 46 (KUP) 2

External Ids for ZBTB25 Gene

Previous HGNC Symbols for ZBTB25 Gene

  • ZNF46
  • C14orf51

Previous GeneCards Identifiers for ZBTB25 Gene

  • GC14M064024
  • GC14M064953
  • GC14M045126

Summaries for ZBTB25 Gene

GeneCards Summary for ZBTB25 Gene

ZBTB25 (Zinc Finger And BTB Domain Containing 25) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZBTB2.

UniProtKB/Swiss-Prot for ZBTB25 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB25 Gene

Genomics for ZBTB25 Gene

Regulatory Elements for ZBTB25 Gene

Enhancers for ZBTB25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F064538 1.1 ENCODE 22.8 -35.3 -35344 4.5 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A FEZF1 ZNF48 BRCA1 YY1 ZBTB25 ZBTB1 PPP1R36 LOC102723809 ENSG00000214770 GCATP1 WDR89 PLEKHG3
GH14F063852 1.3 FANTOM5 ENCODE 16.1 +649.6 649628 6.5 SIN3A ZNF2 SMARCB1 MAFF ZNF610 WT1 SP7 CTCF ZNF146 ZNF140 SYNE2 WDR89 ZBTB25 ENSG00000214770 ZBTB1 PPP2R5E GC14P064073
GH14F064618 0.9 Ensembl ENCODE 21.2 -114.1 -114087 2.1 ZNF680 ZNF223 CHAMP1 MEF2D ZNF664 ZNF791 ZFP3 ZNF558 ZXDB ZBTB1 ZBTB1 ZBTB25 HSPA2 PPP1R36 GC14P064620 NUP50P1
GH14F065351 1.2 Ensembl ENCODE 11.6 -849.5 -849517 6.8 PKNOX1 RAD21 GLIS2 ZNF366 RCOR1 ZNF548 FOS ZNF362 ZNF654 SP3 ZBTB1 LOC102723809 ZBTB25 LOC100506321 FUT8 LOC100128233 GC14M065336 LOC105370537
GH14F063895 1.3 Ensembl ENCODE 9.9 +608.1 608088 3.2 ATF1 YY1 ZNF766 GATA2 KLF13 JUNB CREB3 MEF2D SMARCA4 PBX2 ENSG00000214770 ZBTB25 SYNE2 GC14P064073
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB25 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000419301 513 5401 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207

Genomic Location for ZBTB25 Gene

Chromosome:
14
Start:
64,449,106 bp from pter
End:
64,505,213 bp from pter
Size:
56,108 bases
Orientation:
Minus strand

Genomic View for ZBTB25 Gene

Genes around ZBTB25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB25 Gene

Proteins for ZBTB25 Gene

  • Protein details for ZBTB25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24278-ZBT25_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 25
    Protein Accession:
    P24278
    Secondary Accessions:
    • B3KUX6
    • Q8IYH9

    Protein attributes for ZBTB25 Gene

    Size:
    435 amino acids
    Molecular mass:
    48990 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB25 Gene

Post-translational modifications for ZBTB25 Gene

  • Ubiquitination at Lys 405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB25 Gene

Domains & Families for ZBTB25 Gene

Gene Families for ZBTB25 Gene

Suggested Antigen Peptide Sequences for ZBTB25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24278

UniProtKB/Swiss-Prot:

ZBT25_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB25: view

Function for ZBTB25 Gene

Molecular function for ZBTB25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 2027750
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 2027750
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB25: view
genes like me logo Genes that share phenotypes with ZBTB25: view

Animal Model Products

miRNA for ZBTB25 Gene

miRTarBase miRNAs that target ZBTB25

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB25 Gene

Localization for ZBTB25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB25 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

Pathways & Interactions for ZBTB25 Gene

SuperPathways for ZBTB25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010467 gene expression IEP 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB25 Gene

Transcripts for ZBTB25 Gene

Unigene Clusters for ZBTB25 Gene

Zinc finger and BTB domain containing 25:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - - - - - -
SP3: - - -

Relevant External Links for ZBTB25 Gene

GeneLoc Exon Structure for
ZBTB25
ECgene alternative splicing isoforms for
ZBTB25

Expression for ZBTB25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB25 Gene

Protein differential expression in normal tissues from HIPED for ZBTB25 Gene

This gene is overexpressed in Uterus (22.3), Esophagus (13.8), Salivary gland (9.9), and Fetal gut (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBTB25 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZBTB25 Gene:

ZBTB25

SOURCE GeneReport for Unigene cluster for ZBTB25 Gene:

Hs.654571

mRNA Expression by UniProt/SwissProt for ZBTB25 Gene:

P24278-ZBT25_HUMAN
Tissue specificity: Expressed mainly in hematopoietic cells and testis.
genes like me logo Genes that share expression patterns with ZBTB25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZBTB25 Gene

Orthologs for ZBTB25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB25 34 35
  • 99.77 (n)
cow
(Bos Taurus)
Mammalia ZBTB25 34 35
  • 93.79 (n)
dog
(Canis familiaris)
Mammalia ZBTB25 34 35
  • 93.64 (n)
mouse
(Mus musculus)
Mammalia Zbtb25 34 16 35
  • 90.11 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb25 34
  • 88.51 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB25 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB25 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB25 34 35
  • 67.29 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB25 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb25 34
  • 65.58 (n)
Str.19326 34
zebrafish
(Danio rerio)
Actinopterygii zbtb25 34 35
  • 51.33 (n)
Species where no ortholog for ZBTB25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB25 Gene

ENSEMBL:
Gene Tree for ZBTB25 (if available)
TreeFam:
Gene Tree for ZBTB25 (if available)

Paralogs for ZBTB25 Gene

Paralogs for ZBTB25 Gene

genes like me logo Genes that share paralogs with ZBTB25: view

Variants for ZBTB25 Gene

Sequence variations from dbSNP and Humsavar for ZBTB25 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10131416 -- 64,477,555(+) TCACT(C/G)CCCTC intron-variant
rs10132969 -- 64,486,862(+) TGAAT(A/T)AAAAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10133696 -- 64,504,441(+) CCAGT(C/T)CCATC intron-variant, upstream-variant-2KB
rs10133848 -- 64,481,771(+) AAATG(A/T)CCAAC intron-variant
rs10134530 -- 64,484,240(+) TAAAT(C/G)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB25 Gene

Variant ID Type Subtype PubMed ID
nsv521823 CNV loss 19592680
nsv1126366 CNV deletion 24896259
esv2748779 CNV deletion 23290073

Variation tolerance for ZBTB25 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB25 Gene

Disorders for ZBTB25 Gene

Relevant External Links for ZBTB25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB25

No disorders were found for ZBTB25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB25 Gene

Publications for ZBTB25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. (PMID: 2027750) Chardin P. … Gisselbrecht S. (Nucleic Acids Res. 1991) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ZBTB25 Gene

Sources for ZBTB25 Gene

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