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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB25 Gene

protein-coding   GIFtS: 47
GCID: GC14M064953

Zinc Finger And BTB Domain Containing 25

(Previous names: zinc finger protein 46 (KUP), chromosome 14 open reading...)
(Previous symbols: ZNF46, C14orf51)
  Search for ZBTB25
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 251 2     Zinc Finger Protein KUP2 3
ZNF461 2 3 5     Chromosome 14 Open Reading Frame 511
C14orf511 2 3     Zinc Finger Protein 46 (KUP)1
KUP2 3 5     Zinc Finger And BTB Domain-Containing Protein 252
Zinc Finger Protein 462 3     

External Ids:    HGNC: 131121   Entrez Gene: 75972   Ensembl: ENSG000000897757   OMIM: 1945415   UniProtKB: P242783   

Export aliases for ZBTB25 gene to outside databases

Previous GC identifers: GC14M064024 GC14M045126


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB25 Gene: 
ZBTB25 (zinc finger and BTB domain containing 25) is a protein-coding gene. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB2.

UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB25 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   E2F-2   GATA-2   MEF-2A   POU2F1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB25 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23-q24   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23-q24

ZBTB25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB25 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M064953:  view genomic region     (about GC identifiers)

Start:
64,915,824 bp from pter      End:
64,971,931 bp from pter
Size:
56,108 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 25  
Size: 435 amino acids; 48990 Da
Subcellular location: Nucleus
Secondary accessions: B3KUX6 Q8IYH9

Explore the universe of human proteins at neXtProt for ZBTB25: NX_P24278

Explore proteomics data for ZBTB25 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24278

  • ZBTB25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB25 Protein Expression
    REFSEQ proteins: NP_008908.2  
    ENSEMBL proteins: 
     ENSP00000450718   ENSP00000451046   ENSP00000261683   ENSP00000378204  

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    Cloud-Clone Corp. Proteins for ZBTB25 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA2027750

    ZBTB25 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry P24278

    ProtoNet protein and cluster: P24278

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 2 C2H2-type zinc fingers


    ZBTB25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT25_HUMAN, P24278
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA2027750
    GO:0003700sequence-specific DNA binding transcription factor activity TAS2027750
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB25 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB25:
     Increased cell death HMECs cel 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/21 Interacting proteins for ZBTB25 (P242781, 2, 3 ENSP000002616834) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK9P459842, 3, ENSP000003214104MINT-66910 I2D: score=5 STRING: ENSP00000321410
    COILP384322, 3, ENSP000002403164MINT-2864246 I2D: score=3 STRING: ENSP00000240316
    MDFIQ997501, 2, 3, ENSP000002303214EBI-739899,EBI-724076 MINT-66714 I2D: score=6 STRING: ENSP00000230321
    KXD1Q9BQD32, 3, ENSP000002223074MINT-67241 I2D: score=4 STRING: ENSP00000222307
    SORBS3O605043, ENSP000002401234I2D: score=5 STRING: ENSP00000240123
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010467gene expression IEP2027750

    ZBTB25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB25 (ZBT25)

    Search CenterWatch for drugs/clinical trials and news about ZBTB25 / ZBT25

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB25 gene: 
    NM_006977.2  

    Unigene Cluster for ZBTB25:

    Zinc finger and BTB domain containing 25
    Hs.654571  [show with all ESTs]
    Unigene Representative Sequence: AK098181
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555220(uc001xhc.3) ENST00000555424 ENST00000261683(uc001xhf.3)
    ENST00000394715(uc001xhg.3)
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB25
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    Additional mRNA sequence: 

    AK098181.1 AK313889.1 BC035804.1 X16576.1 

    3 DOTS entries:

    DT.75104387  DT.120751954  DT.40283744 

    24 AceView cDNA sequences:

    BQ446864 BC035804 BX094827 CB138430 NM_006977 BQ446833 AK098181 AI282142 
    AI768653 X16576 BX479957 BM727842 AL598866 BV196384 BG025956 AI802967 
    BU603554 BM546773 AI984553 AW449363 BG327685 BG214864 BM550005 AI435898 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB25    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                      
    SP2:        -     -     -     -     -     -               
    SP3:                          -     -     -               


    ECgene alternative splicing isoforms for ZBTB25

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATACACACA
    ZBTB25 Expression
    About this image


    See ZBTB25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB25

    SOURCE GeneReport for Unigene cluster: Hs.654571

    UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278
    Tissue specificity: Expressed mainly in hematopoietic cells and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB25 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb251 , 5 zinc finger and BTB domain containing 251, 5 90.11(n)1
    91.72(a)1
      12 (33.73 cM)5
    1099291  NM_001172104.11  NP_001165575.11 
     763477825 
    chicken
    (Gallus gallus)
    Aves ZBTB251 zinc finger and BTB domain containing 25 67.21(n)
    68.69(a)
      423505  XM_421407.3  XP_421407.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB256
    Uncharacterized protein
    70(a)
    1 ↔ 1
    1(1413304-1423423)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.193262 Transcribed sequence with weak similarity to protein more 75.88(n)    AL849602.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb251 zinc finger and BTB domain containing 25 50.56(n)
    45.69(a)
      567401  XM_690696.1  XP_695788.1 


    ENSEMBL Gene Tree for ZBTB25 (if available)
    TreeFam Gene Tree for ZBTB25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB25 gene
    ZBTB22  ZBTB12  
    18/25 SIMAP similar genes for ZBTB25 using alignment to 3 protein entries:     ZBT25_HUMAN (see all proteins) (see all similar genes):
    ZBTB17    ZBTB4    ZBTB7C    ZBTB1    MYNN    KLHL32
    ZBTB49    ZBTB20    HIC1    ZBTB14    KLHL28    ZBTB45
    ZNF131    ZBTB38    BACH2    BACH1    KLHL36    ZBTB21

    ZBTB25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 SNPs in ZBTB25 are shown (see all 411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397207971,2
    --45939716(+) GTAAAC/GAGAAG 1 -- ds50010--------
    rs1905351751,2
    --45939756(+) AGTTAA/TAAAAT 1 -- ds50010--------
    rs1823749941,2
    --45939782(+) TTGGTA/GTATCT 1 -- ds50010--------
    rs1870858261,2
    --45939893(+) CTGGTA/CGGAGT 1 -- ds50010--------
    rs116262221,2
    C,F,H--45939917(+) ATGTAG/AGCAGA 1 -- ds50016Minor allele frequency- A:0.24NA WA EA 364
    rs1925829231,2
    --45939926(+) GAAGTC/GATAGT 1 -- ds50010--------
    rs740564331,2
    C--45939996(+) CTATAA/CCTGGA 1 -- ds50012Minor allele frequency- C:0.07WA 120
    rs1137986671,2
    F--45940079(+) TATTTC/TGTTTG 1 -- ds50012Minor allele frequency- T:0.06CSA NA 123
    rs782282591,2
    C,F--45940080(+) ATTTCG/ATTTGT 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1493198801,2
    --45940089(+) GTGAAA/TAGTTC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZBTB25 (64915824 - 64971931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZBTB25:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748779CNV Deletion23290073
    nsv521823CNV Loss19592680
    nsv902022CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZBTB25 for disorders           About MalaCards
    OMIM gene information: 194541    OMIM disorders: --


    ZBTB25 for disorders           About GeneDecksing


    Export disorders for ZBTB25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB25 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZBTB25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. (PubMed id 2027750)1, 2 Chardin P.... Gisselbrecht S. (1991)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Gene enrichment profiles reveal T-cell development, d ifferentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. (PubMed id 20410506)1 Benita Y....Xavier R.J. (2010)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (2009)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7597 HGNC: 13112 AceView: ZNF46 Ensembl:ENSG00000089775 euGenes: HUgn7597
    ECgene: ZBTB25 H-InvDB: ZBTB25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB25 gene:
    Search GeneIP for patents involving ZBTB25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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