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ZBTB25 Gene

protein-coding   GIFtS: 50

GC14M064024
zinc finger and BTB domain containing 25
(Previous name: zinc finger protein 46 (KUP) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF46)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KUP 1, 2, 3
OTTHUMP00000180663 2
ZNF46 2, 3
Descriptions
Zinc finger protein 46 2, 3
Zinc finger protein KUP 3
zinc finger and BTB domain containing 25 2
zinc finger protein 46 (KUP) 1
External Ids
HGNC: 131121
Entrez Gene: 75972
UniProtKB: P242783
Ensembl: ENSG000000897757
Search outside databases for aliases for ZBTB25 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278
Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB25 gene  

Entrez Gene cytogenetic band: 14q23-q24   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23-q24

ZBTB25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M064024:     (about GC identifiers)

Start:
64,023,308 bp from pter
End:
64,041,055 bp from pter
Size:
17,748 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 25  
Size: 435 amino acids; 48990 Da
Subcellular location: Nucleus
Secondary accessions: Q8IYH9

REFSEQ proteins: NP_008908.2  

ENSEMBL proteins: 
ENSP00000261683 ENSP00000378204 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ZBTB25)
Human Recombinant Proteins from Abnova (ZBTB25)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
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Antibodies for ZBTB25: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for ZBTB25
Browse R&D Systems for Antibodies
Antibodies from Abcam (ZBTB25), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ZBTB25)
Novus Biologicals Antibodies for ZBTB25

Assays for ZBTB25: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR000210 BTB/POZ-like
 IPR015880 Znf_C2H2-like
 IPR011333 BTB/POZ_fold
 IPR013069 BTB_POZ
 IPR007087 Znf_C2H2


   GeneDecks  ZBTB25 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P24278

ProtoNet protein and cluster: P24278

2 Blocks protein families:
IPB000210 BTB/POZ domain
IPB007086 C2H2-type zinc finger signature


UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 2 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB25)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBTB25)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006977

              Applied Biosystems Silencer® siRNAs for ZBTB25

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB25  
                     Sigma-Aldrich shRNA for ZBTB25  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ZBTB25
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006977
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006977
                                 untagged cDNA clone in CMV expression vector: NM_006977 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006977

UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278
Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity TAS2027750
GO:0005515 protein binding IPI16189514
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/6 Interacting proteins for ZBTB25 (P242781, 2) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
MDFIQ997501, 2EBI-739899, EBI-724076 MINT-66714 EBI-739899, EBI-724076 MINT-66714
MDFIQ997501, 2EBI-739899, EBI-724076 MINT-66714 EBI-739899, EBI-724076 MINT-66714
C19orf50Q9BQD32MINT-67241
COILP384322MINT-2864246
MAPK9P459842MINT-66910
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB25

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB25)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBTB25)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006977

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB25  
                     Sigma-Aldrich shRNA for ZBTB25  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006977  

REFSEQ mRNAs for ZBTB25 gene: 

NM_006977.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006977  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006977
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006977
                                 untagged cDNA clone in CMV expression vector: NM_006977 

Additional cDNA sequence: 

AK098181.1 AK313889.1 BC035804.1 X16576.1 

4 DOTS entries:

DT.75104387  DT.120751954  DT.40283744  DT.100755516 

24 AceView cDNA sequences:

BQ446864 NM_006977 AI768653 BX094827 BC035804 BQ446833 AI282142 AK098181 
CB138430 BV196384 AW449363 BX479957 AL598866 X16576 AI984553 BU603554 
BM546773 AI802967 BM727842 BG025956 BM550005 BG327685 BG214864 AI435898 

highest scoring ESTs for ZBTB25:

AI435898 AK098181 BC035804 BM550005 BX094827 X16576 AI984553 AW362407 AW449363 BG025956 

Unigene Cluster for ZBTB25:

Zinc finger and BTB domain containing 25
Hs.654571  [show with all ESTs]
Unigene Representative Sequence: AK098181


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB25

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:                                                      
SP2:        -     -     -     -     -     -               
SP3:                          -     -     -               

About this scheme

ECgene alternative splicing isoforms for ZBTB25

2 Ensembl transcripts including schematic representations:
ENST00000261683  ENST00000394715  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB25 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB25

1 / 2 / 3

5 probe-sets matching ZBTB25 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

332_at2, 3 U95-A 1 1.00 1.00 0.89 1.15 HG2573-HT2669 0.20 1.00 0.72 1

33616_at2, 3 U95-A 1 1.00 1.00 0.95 0.86 X16576 0.80 1.00 0.91 1

33617_s_at2, 3 U95-A 1 1.00 1.00 0.64 0.63 AI435898 0.80 1.00 0.91 1

214482_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006977 0.60 1.00 0.82 1

214482_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TATACACACA

SOURCE GeneReport for Unigene cluster: Hs.654571

Expression variation in blood from EXPOLDB for ZBTB25

UniProtKB/Swiss-Prot: ZBT25_HUMAN, P24278
Tissue specificity: Expressed mainly in hematopoietic cells and testis

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ZBTB25 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZBTB251   -- zinc finger and BTB domain containing 25 93.64(n)
94.48(a)
490730  XM_547852.2  XP_547852.1 
cow
(Bos taurus)
ZBTB251   -- zinc finger and BTB domain containing 25 93.79(n)
94.71(a)
538889  XM_583474.3  XP_583474.3 
rat
(Rattus norvegicus)
Zbtb251   -- zinc finger and BTB domain containing 25 88.51(n)
89.66(a)
314245  NM_199496.1  NP_955790.1 
mouse
(Mus musculus)
Zbtb251, 5 12 (31.00 cM)5
zinc finger and BTB domain containing 251, 5 88.92(n)1
89.13(a)1
1099291  NM_028356.11  NP_082632.11 
 AI8421285  AK0133745  (see all 9)
chicken
(Gallus gallus)
ZBTB251   -- zinc finger and BTB domain containing 25 70.05(n)
74.22(a)
423505  XM_421407.2  XP_421407.2 
About this table        Species with no ortholog for ZBTB25

ENSEMBL Gene Tree for ZBTB25
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ZBTB25 gene
ZBTB22  ZBTB12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/112 NCBI SNPs in ZBTB25 are shown (see all 112 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 50)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 14 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs101329691,2
A,C64023333(+) TGAATA/TAAAAA 1 -- ut310--------
rs101438391,2
C64023344(+) TGCCAC/TGCAAA 1 -- ut31 ese30--------
rs101428791,2
A,C,F,H64035595(+) TCAAAC/TTAAGT 1 -- int14Minor allele frequency- T:0.19EU EA WA 402
rs118512361,2
A,C,F,H64030384(+) CTACCA/GGGTAT 1 -- int14Minor allele frequency- G:0.27EU EA WA 420
rs80224471,2
A,C,F,H64029065(+) GATAAA/GTTGTC 1 -- int18Minor allele frequency- G:0.18EU EA WA 838
rs21983471,2
A,C,F,H64039095(+) CATAAC/ACTGAA 1 -- int117Minor allele frequency- A:0.20NS EU EA WA 1366
rs120502381,2
A,F,H64034628(+) TGAAAC/GAATGT 1 -- int14Minor allele frequency- G:0.19EU EA WA 420
rs20571301,2
C,F,H64031232(-) AGGTTT/GCTTTC 1 -- int125Minor allele frequency- G:0.45NS EU EA WA NA 1942
rs22189941,2
C,F,H64038978(+) TGAAAT/CTTTCA 1 -- int110Minor allele frequency- C:0.19EU EA WA NA 1006
--
rs46320451,2
A,C,F64032879(+) tgaacC/Tgggac 1 -- int13Minor allele frequency- T:0.26NA 142
About this table

HapMap Linkage Disequilibrium images for ZBTB25 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 194541

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for ZBTB25 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7597 HGNC: 13112 AceView: ZNF46 Ensembl:ENSG00000089775 euGenes: HUgn7597
ECgene: ZBTB25 H-InvDB: ZBTB25
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBTB25:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Millipore Preclinical / Clinical Development Services
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 Predesigned and custom siRNAs for ZBTB25 Antibodies for ZBTB25
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ZBTB25 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Antibodies for ZBTB25

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