Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBTB25 Gene

Aliases for ZBTB25 Gene

  • Zinc Finger And BTB Domain Containing 25 2 3
  • ZNF46 3 4 6
  • KUP 3 4 6
  • Zinc Finger Protein KUP 3 4
  • Zinc Finger Protein 46 3 4
  • C14orf51 3 4
  • Zinc Finger And BTB Domain-Containing Protein 25 3
  • Chromosome 14 Open Reading Frame 51 2
  • Zinc Finger Protein 46 (KUP) 2

External Ids for ZBTB25 Gene

Previous HGNC Symbols for ZBTB25 Gene

  • ZNF46
  • C14orf51

Previous GeneCards Identifiers for ZBTB25 Gene

  • GC14M064024
  • GC14M064953
  • GC14M045126

Summaries for ZBTB25 Gene

GeneCards Summary for ZBTB25 Gene

ZBTB25 (Zinc Finger And BTB Domain Containing 25) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB2.

UniProtKB/Swiss-Prot for ZBTB25 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB25 Gene

Genomics for ZBTB25 Gene

Regulatory Elements for ZBTB25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB25 Gene

64,449,106 bp from pter
64,505,213 bp from pter
56,108 bases
Minus strand

Genomic View for ZBTB25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB25 Gene

Proteins for ZBTB25 Gene

  • Protein details for ZBTB25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 25
    Protein Accession:
    Secondary Accessions:
    • B3KUX6
    • Q8IYH9

    Protein attributes for ZBTB25 Gene

    435 amino acids
    Molecular mass:
    48990 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB25 Gene

Proteomics data for ZBTB25 Gene at MOPED

Post-translational modifications for ZBTB25 Gene

  • Ubiquitination at Lys405
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB25 Gene

No data available for DME Specific Peptides for ZBTB25 Gene

Domains for ZBTB25 Gene

Gene Families for ZBTB25 Gene

  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZBTB25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P24278
  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB25: view

Function for ZBTB25 Gene

Molecular function for ZBTB25 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 2027750
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 2027750
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB25: view

Phenotypes for ZBTB25 Gene

GenomeRNAi human phenotypes for ZBTB25:
genes like me logo Genes that share phenotypes with ZBTB25: view

Animal Model Products

CRISPR Products

miRNA for ZBTB25 Gene

miRTarBase miRNAs that target ZBTB25

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB25 Gene

Localization for ZBTB25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB25 Gene

Subcellular locations from

Jensen Localization Image for ZBTB25 Gene COMPARTMENTS Subcellular localization image for ZBTB25 gene
Compartment Confidence
nucleus 5
cytosol 2
vacuole 1

Gene Ontology (GO) - Cellular Components for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

Pathways for ZBTB25 Gene

SuperPathways for ZBTB25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010467 gene expression IEP 2027750
genes like me logo Genes that share ontologies with ZBTB25: view

No data available for Pathways by source for ZBTB25 Gene

Transcripts for ZBTB25 Gene

Unigene Clusters for ZBTB25 Gene

Zinc finger and BTB domain containing 25:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB25

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB25 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: - - - - - -
SP3: - - -

Relevant External Links for ZBTB25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB25 Gene

mRNA expression in normal human tissues for ZBTB25 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZBTB25 Gene

SOURCE GeneReport for Unigene cluster for ZBTB25 Gene Hs.654571

mRNA Expression by UniProt/SwissProt for ZBTB25 Gene

Tissue specificity: Expressed mainly in hematopoietic cells and testis
genes like me logo Genes that share expressions with ZBTB25: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZBTB25 Gene

Orthologs for ZBTB25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB25 35
  • 99.77 (n)
  • 99.77 (a)
ZBTB25 36
  • 100 (a)
(Bos Taurus)
Mammalia ZBTB25 35
  • 93.79 (n)
  • 94.71 (a)
ZBTB25 36
  • 95 (a)
(Canis familiaris)
Mammalia ZBTB25 35
  • 93.64 (n)
  • 94.48 (a)
ZBTB25 36
  • 94 (a)
(Mus musculus)
Mammalia Zbtb25 35
  • 90.11 (n)
  • 91.72 (a)
Zbtb25 16
Zbtb25 36
  • 90 (a)
(Monodelphis domestica)
Mammalia ZBTB25 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB25 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Zbtb25 35
  • 88.51 (n)
  • 89.66 (a)
(Gallus gallus)
Aves ZBTB25 35
  • 67.29 (n)
  • 68.69 (a)
ZBTB25 36
  • 60 (a)
(Anolis carolinensis)
Reptilia ZBTB25 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19326 35
zbtb25 35
  • 65.58 (n)
  • 59.3 (a)
(Danio rerio)
Actinopterygii zbtb25 35
  • 51.33 (n)
  • 46.27 (a)
zbtb25 36
  • 41 (a)
Species with no ortholog for ZBTB25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB25 Gene

Gene Tree for ZBTB25 (if available)
Gene Tree for ZBTB25 (if available)

Paralogs for ZBTB25 Gene

Paralogs for ZBTB25 Gene

genes like me logo Genes that share paralogs with ZBTB25: view

Variants for ZBTB25 Gene

Sequence variations from dbSNP and Humsavar for ZBTB25 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs367483 -- 64,490,378(+) AAAAA(A/T)ATCAT reference, synonymous-codon
rs378678 -- 64,485,425(-) TTTCT(A/G)AAATG intron-variant
rs390873 -- 64,485,384(-) TAATA(A/G)AACAG intron-variant
rs393095 -- 64,485,348(-) AAATT(A/C)TAAGC intron-variant
rs402947 -- 64,490,575(-) CATAC(A/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB25 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv902022 CNV Gain 21882294
nsv521823 CNV Loss 19592680

Relevant External Links for ZBTB25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB25 Gene

Disorders for ZBTB25 Gene

No disorders were found for ZBTB25 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB25 Gene

Publications for ZBTB25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. (PMID: 2027750) Chardin P. … Gisselbrecht S. (Nucleic Acids Res. 1991) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ZBTB25 Gene

Sources for ZBTB25 Gene

Back to Top