Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ZBTB24 Gene

protein-coding   GIFtS: 53
GCID: GC06M109784

Zinc Finger And BTB Domain Containing 24

(Previous name: zinc finger protein 450)
(Previous symbol: ZNF450)
  See ZBTB24-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Zinc Finger And BTB Domain Containing 241 2     PATZ22 5
ZNF4501 2 3 5     KIAA04413 5
Zinc Finger Protein 4501 2 3     BIF12
POZ (BTB) And AT Hook Containing Zinc Finger 21 2     Zinc Finger And BTB Domain-Containing Protein 242
ICF22 5     

External Ids:    HGNC: 211431   Entrez Gene: 98412   Ensembl: ENSG000001123657   OMIM: 6140645   UniProtKB: O431673   

Export aliases for ZBTB24 gene to outside databases

Previous GC identifers: GC06M109830 GC06M109890 GC06M107349


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ZBTB24 Gene:
This gene encodes a protein similar to a protein in rodents which is induced by bone morphogenic protein 2 in
vitro. (provided by RefSeq, Aug 2011)

GeneCards Summary for ZBTB24 Gene:
ZBTB24 (zinc finger and BTB domain containing 24) is a protein-coding gene. Diseases associated with ZBTB24 include immunodeficiency-centromeric instability-facial anomalies syndrome-2, and immunodeficiency-centromeric instability-facial anomalies syndrome 1. An important paralog of this gene is ZNF131.

UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
Function: May be involved in BMP2-induced transcription (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB24 gene promoter:
         HOXA9B   HOXA9   SRF   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2   Meis-1b   CREB   deltaCREB   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB24 promoter sequence
   Search Chromatin IP Primers for ZBTB24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

ZBTB24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB24 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M109784:  view genomic region     (about GC identifiers)

Start:
109,783,719 bp from pter      End:
109,804,440 bp from pter
Size:
20,722 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 24  
Size: 697 amino acids; 78282 Da
Developmental stage: Regulated expression during B-cell differentiation. Low expression in pro-B cells, pre-B I
cells and large pre-B II cells. Levels peak in small pre-B II and then slightly decrease in immature B-cells. Low
levels in CD34+ umbilical cord blood cells
Sequence caution: Sequence=BAA23713.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q17RC6 Q5TED5 Q8N455
Alternative splicing: 2 isoforms:  O43167-1   O43167-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZBTB24: NX_O43167

Explore proteomics data for ZBTB24 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157785.1  NP_055612.2  

    ENSEMBL proteins: 
     ENSP00000230122  

    ZBTB24 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ZBTB24
    OriGene Protein Over-expression Lysate for ZBTB24
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ZBTB24
    GenScript Custom Purified and Recombinant Proteins Services for ZBTB24
    Novus Biologicals ZBTB24 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZBTB24

     
    Search eBioscience for Proteins for ZBTB24 

     
    antibodies-online proteins for ZBTB24 (2 products) 

     
    Search antibodies-online for peptides for ZBTB24

    ZBTB24 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ZBTB24
    OriGene Custom Antibody Services for ZBTB24
    Novus Biologicals ZBTB24 Antibody
    Abcam antibodies for ZBTB24
    Cloud-Clone Corp. Antibodies for ZBTB24
    ThermoFisher Antibodies for ZBTB24
    antibodies-online antibodies for ZBTB24 (9 products) 

    ZBTB24 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZBTB24
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZBTB24
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZBTB24
    Cloud-Clone Corp. CLIAs for ZBTB24
    Search eBioscience for ELISAs for ZBTB24 
    antibodies-online kits for ZBTB24 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 7):
     IPR017956 AT_hook_DNA-bd_motif
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry O43167

    ProtoNet protein and cluster: O43167

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 8 C2H2-type zinc fingers


    Find genes that share domains with ZBTB24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT24_HUMAN, O43167
    Function: May be involved in BMP2-induced transcription (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB24           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Zbtb24 (no phenotypes)

    Find genes that share phenotypes with ZBTB24           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZBTB24

    miRNA
    Products:
        
    miRTarBase miRNAs that target ZBTB24:
    hsa-let-7d-5p (MIRT032132), hsa-mir-151a-3p (MIRT019507), hsa-mir-98-5p (MIRT027732), hsa-mir-196a-5p (MIRT026030)

    Block miRNA regulation of human, mouse, rat ZBTB24 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ZBTB24:
    hsa-miR-1178 hsa-miR-361-5p hsa-miR-640 hsa-miR-222* hsa-miR-4282 hsa-miR-183* hsa-miR-3658 hsa-miR-936
    SwitchGear 3'UTR luciferase reporter plasmidZBTB24 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZBTB24
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB24

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZBTB24

    Clone
    Products:
         
    OriGene clones in human, mouse for ZBTB24 (see all 12)
    OriGene ORF clones in mouse, rat for ZBTB24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZBTB24 (NM_001164313)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB24

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZBTB24
    Browse ESI BIO Cell Lines and PureStem Progenitors for ZBTB24 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB24


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT24_HUMAN, O43167: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZBTB24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB24
    Interactions:

        Search GeneGlobe Interaction Network for ZBTB24

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for ZBTB24 (O431671, 2, 3 ENSP000002301224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 2, 3, ENSP000002303214EBI-744471,EBI-724076 MINT-66511 I2D: score=5 STRING: ENSP00000230321
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    STK24Q9Y6E03, ENSP000003657304I2D: score=1 STRING: ENSP00000365730
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZBTB24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB24 (ZBT24)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ZBTB24 gene (2 alternative transcripts): 
    NM_001164313.1  NM_014797.2  

    Unigene Cluster for ZBTB24:

    Zinc finger and BTB domain containing 24
    Hs.409876  [show with all ESTs]
    Unigene Representative Sequence: NM_014797
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000230122(uc011ear.1 uc010kds.1 uc010kdt.1 uc003ptl.1 uc003ptm.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZBTB24 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ZBTB24:
    hsa-miR-1178 hsa-miR-361-5p hsa-miR-640 hsa-miR-222* hsa-miR-4282 hsa-miR-183* hsa-miR-3658 hsa-miR-936
    SwitchGear 3'UTR luciferase reporter plasmidZBTB24 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZBTB24
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB24
    Clone
    Products:
         
    OriGene clones in human, mouse for ZBTB24 (see all 12)
    OriGene ORF clones in mouse, rat for ZBTB24
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZBTB24 (NM_001164313)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB24
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB24
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB24
      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB24
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB24

    Additional mRNA sequence: 

    AB007901.1 AK309697.1 BC036731.1 BC117374.1 BC117376.1 BC143843.1 BX648883.1 

    3 DOTS entries:

    DT.213035  DT.75140792  DT.99945138 

    Selected AceView cDNA sequences (see all 73):

    BF056821 BX104454 BE089355 AB007901 BM719348 N28020 AI651469 AW204345 
    BU147166 AI350628 AI373056 AI560841 BM834676 BG141354 CA414902 CD657125 
    CB132353 BU676140 CD642591 AA725796 AI150217 BC036731 AI968019 BP344433 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB24    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                                      -                                 
    SP2:                          -           -                                 
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for ZBTB24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ZBTB24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTAGTGG
    ZBTB24 Expression
    About this image

    ZBTB24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.409876

    UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
    Tissue specificity: Widely expressed, with highest levels in naive B-cells

        Custom PCR Arrays for ZBTB24
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB24
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB24
    QuantiTect SYBR Green Assays in human, mouse, rat ZBTB24
    QuantiFast Probe-based Assays in human, mouse, rat ZBTB24
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB24 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb241 , 5 zinc finger and BTB domain containing 241, 5 84.41(n)1
    85.58(a)1
      10 (22.38 cM)5
    2682941  NM_153398.31  NP_700447.21 
     414503965 
    chicken
    (Gallus gallus)
    Aves ZBTB241 zinc finger and BTB domain containing 24 72.95(n)
    73.15(a)
      421763  XM_419793.4  XP_419793.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB246
    zinc finger and BTB domain containing 24
    64(a)
    1 ↔ 1
    1(191154417-191162188)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76362 Xenopus laevis transcribed sequence with weak similarity more 74.52(n)    BX846468.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb241 zinc finger and BTB domain containing 24 59(n)
    53.98(a)
      553955  NM_001023572.1  NP_001018866.1 


    ENSEMBL Gene Tree for ZBTB24 (if available)
    TreeFam Gene Tree for ZBTB24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ZBTB24 gene
    ZNF1312  
    9 SIMAP similar genes for ZBTB24 using alignment to 1 protein entry:     ZBT24_HUMAN:
    ZNF589    ZNF501    ZNF514    ZNF669    ZNF419    ZNF80
    ZNF561    CTCFL    MYNN

    Find genes that share paralogs with ZBTB24           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ZBTB24 (see all 455)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0658464
    Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2)4--see VAR_0658462 C G mis40--------
    rs715390901,2
    C,F--107370717(+) TGCAGT/GCCTGG 2 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1138562941,2
    C--109781538(+) CTCCT-/CACT  
      CAGATG
    CCAGT
    1 -- ds50011Minor allele frequency- CACTCAGATG:0.00CSA 2
    rs94871171,2
    C,F,H--109781681(+) ccataC/Taactg 1 -- ds500110Minor allele frequency- T:0.04NS EA NA WA 1310
    rs797061321,2
    C--109781791(+) ACACGC/TTGATC 1 -- ds50010--------
    rs737627551,2
    C,F--109781948(+) GATGTT/CTGAGA 1 -- ds50015Minor allele frequency- C:0.19WA CSA NA 243
    rs1852279051,2
    --109782061(+) CCTAGA/CTAAGC 1 -- ut310--------
    rs412885641,2
    C--109782180(+) GAAAAC/TACAGA 1 -- ut310--------
    rs1901255341,2
    --109782220(+) AAGCAC/TTTGAA 1 -- ut310--------
    rs1433227771,2
    --109782241(+) TGATGG/TTAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZBTB24 (109783719 - 109804440 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZBTB24:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510045CNV Loss20534489

    Human Gene Mutation Database (HGMD): ZBTB24
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB24
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614064   
    OMIM disorders: 614069  
    UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
  • Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2) [MIM:614069]: A rare disorder
    characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching
    of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and
    psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome
    in some, but not all, patients. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 2 diseases for ZBTB24:    
    About MalaCards
    immunodeficiency-centromeric instability-facial anomalies syndrome-2    immunodeficiency-centromeric instability-facial anomalies syndrome 1


    Find genes that share disorders with ZBTB24           About GenesLikeMe

    Genetic Association Database (GAD): ZBTB24

    Export disorders for ZBTB24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ZBTB24 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZBTB24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    2. Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. (PubMed id 21596365)1, 2 de Greef J.C.... van der Maarel S.M. (Am. J. Hum. Genet. 2011)
    3. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients. (PubMed id 23739126)1 Nitta H....Sasaki H. (J. Hum. Genet. 2013)
    10. A novel deletion in ZBTB24 in a Lebanese family with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. (PubMed id 21906047)1 Chouery E....MAcgarbanAc A. (Clin. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9841 HGNC: 21143 AceView: ZBTB24 Ensembl:ENSG00000112365 euGenes: HUgn9841
    ECgene: ZBTB24 H-InvDB: ZBTB24

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0441

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ZBTB24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ZBTB24 gene:
    Search GeneIP for patents involving ZBTB24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZBTB24   OriGene RNAi products in human, mouse, rat for ZBTB24  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZBTB24  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZBTB24  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB24   OriGene Purified Protein for ZBTB24  
     OriGene ORF clones in mouse, rat for ZBTB24   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZBTB24   OriGene Custom Protein Services for ZBTB24  

     
     
     Block miRNA regulation of human, mouse, rat ZBTB24 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZBTB24
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB24 Predesigned siRNA for gene silencing in human, mouse, rat ZBTB24
     QuantiFast Probe-based Assays in human, mouse, rat ZBTB24 QuantiTect SYBR Green Assays in human, mouse, rat ZBTB24
     Custom PCR Arrays for ZBTB24 Search Chromatin IP Primers for ZBTB24
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB24  Search GeneGlobe Interaction Network for ZBTB24
     Regulatory tfbs in ZBTB24 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ZBTB24 GenScript cDNA clones with any tag delivered in your preferred vector for ZBTB24
     GenScript Custom Assay Services for ZBTB24 GenScript Custom overexpressing Cell Line Services for ZBTB24
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ZBTB24 (ZBT24)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ZBTB24 antibodies
     ZBTB24 lysates
     Antibodies for ZBTB24
     See all of Abcam's Antibodies, Kits and Proteins for ZBTB24
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ZBTB24
     Antibodies for ZBTB24
     ELISAs for ZBTB24
     CLIAs for ZBTB24



     Browse ESI BIO Cell Lines and PureStem Progenitors for ZBTB24
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB24
     SwitchGear 3'UTR luciferase reporter plasmids for ZBTB24
     SwitchGear Promoter luciferase reporter plasmids for ZBTB24
     ThermoFisher Antibodies for ZBTB24
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB24
     Browse compounds at ApexBio
     Search Addgene for plasmids for ZBTB24
      Search eBioscience for proteins for ZBTB24
      Search eBioscience for elisas for ZBTB24
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ZBTB24
     antibodies-online antibodies for ZBTB24 (9 products)
     antibodies-online kits for ZBTB24 (6 products)
      Search antibodies-online for peptides for ZBTB24
     antibodies-online proteins for ZBTB24 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZBTB24 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4