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ZBTB24 Gene

protein-coding   GIFtS: 50

GC06M109890
zinc finger and BTB domain containing 24
(Previous name: zinc finger protein 450 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF450)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BIF1 1, 2
KIAA0441 1, 3
OTTHUMP00000016968 2
PATZ2 1, 2
ZNF450 2, 3
Descriptions
POZ (BTB) and AT hook containing zinc finger 2 2
Zinc finger protein 450 1, 2, 3
zinc finger and BTB domain containing 24 2
External Ids
HGNC: 211431
Entrez Gene: 98412
UniProtKB: O431673
Ensembl: ENSG000001123657
Search outside databases for aliases for ZBTB24 gene

Previous GC identifer: GC06M109830

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
Function: May be involved in BMP2-induced transcription (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB24 gene  

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

ZBTB24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M109890:     (about GC identifiers)

Start:
109,890,412 bp from pter
End:
109,911,133 bp from pter
Size:
20,722 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 24  
Size: 697 amino acids; 78282 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q17RC6 Q5TED5 Q8N455
Alternative splicing: 2 isoforms:  O43167-1   O43167-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055612.1  

    ENSEMBL proteins: 
    ENSP00000230122 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB24: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZBTB24

    Assays for ZBTB24: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR017956 AT_hook_DNA-bd_CS
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd


       GeneDecks  ZBTB24 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O43167

    ProtoNet protein and cluster: O43167

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 8 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB24)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB24)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014797

                  Applied Biosystems Silencer® siRNAs for ZBTB24

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB24  
                         Sigma-Aldrich shRNA for ZBTB24  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014797
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014797
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_014797 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014797

    UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
    Function: May be involved in BMP2-induced transcription (By similarity)

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for ZBTB24 (O431672) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502MINT-66511
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB24

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB24)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB24)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014797

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB24  
                         Sigma-Aldrich shRNA for ZBTB24  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014797  

    REFSEQ mRNAs for ZBTB24 gene: 

    NM_014797.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014797  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014797
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014797
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_014797 

    Additional cDNA sequence: 

    AB007901.1 AK309697.1 BC036731.1 BC117374.1 BC117376.1 BC143843.1 BX648883.1 

    3 DOTS entries:

    DT.213035  DT.75140792  DT.99945138 

    24/73 AceView cDNA sequences (see all 73 ):

    AI350628 BU147166 BM719348 AI560841 BX104454 AW204345 AI373056 AB007901 
    BF056821 BE089355 AI651469 N28020 AI499916 CA414902 BG254273 CF136276 
    BC036731 CF121136 AI560248 BQ109224 BI253824 BU616623 AA993565 BM832246 

    highest scoring ESTs for ZBTB24:

    AB007901 BC036731 BM475454 AA248762 AA725796 AI150217 AI381906 AI560841 AI866589 AW204345 

    Unigene Cluster for ZBTB24:

    Zinc finger and BTB domain containing 24
    Hs.409876  [show with all ESTs]
    Unigene Representative Sequence: NM_014797


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB24

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
    SP1:                                      -                                 
    SP2:                          -           -                                 
    SP3:                                                                        
    SP4:                                                                        

    About this scheme

    ECgene alternative splicing isoforms for ZBTB24

    1 Ensembl transcript including schematic representation:
    ENST00000230122  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB24 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB24

    1 / 2 / 3

    5 probe-sets matching ZBTB24 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    39658_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB007901 1.00 1.00 1.00 1

    205340_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014797 0.60 1.00 0.82 1

    205340_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554037_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554036_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGGCTAGTGG

    SOURCE GeneReport for Unigene cluster: Hs.409876

    Expression variation in blood from EXPOLDB for ZBTB24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB24 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB241   -- zinc finger and BTB domain containing 24 88.49(n)
    89.7(a)
    475021  XM_532257.2  XP_532257.2 
    chimpanzee
    (Pan troglodytes)
    ZBTB241   -- zinc finger and BTB domain containing 24 99.57(n)
    99.43(a)
    740227  XM_001153734.1  XP_001153734.1 
    cow
    (Bos taurus)
    ZBTB241   -- zinc finger and BTB domain containing 24 91.67(n)
    94.11(a)
    539966  XM_590553.3  XP_590553.3 
    mouse
    (Mus musculus)
    Zbtb241, 5 105
    zinc finger and BTB domain containing 241, 5 82.94(n)1
    83.98(a)1
    2682941  NM_153398.21  NP_700447.21 
     AF2630105  AK0540975  (see all 18)
    chicken
    (Gallus gallus)
    ZBTB241   -- zinc finger and BTB domain containing 24 69.23(n)
    67.13(a)
    421763  XM_419793.2  XP_419793.2 
    About this table        Species with no ortholog for ZBTB24

    ENSEMBL Gene Tree for ZBTB24
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB24 gene
    ZBTB7C2  ZBTB7A2  ZBTB7B2  ZBTB442  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/101 NCBI SNPs in ZBTB24 are shown (see all 101 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 64)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10469431,2
    A,C,F,H,O109890634(-) GATGAC/TTGGAG 1 -- ut31 ese315Minor allele frequency- T:0.45EA MN NA EU WA 2838
    rs107821621,2
    A,C,F,H109912956(+) TTAAAT/ACTTGC 1 -- ng31 tfbs34Minor allele frequency- A:0.29EU EA WA 416
    rs37346521,2
    A,C,F,H109893673(+) CCTGAC/TTTCAA 1 -- ut318Minor allele frequency- T:0.42EA NA EU WA 2058
    rs123332971,2
    A,F,H109891789(+) gttcaT/Cgttat 1 -- ut314Minor allele frequency- C:0.01EU EA WA 404
    rs22324481,2
    C,F,H109894289(-) AGCATG/ACTTCA 1 T/A mis1 ese38Minor allele frequency- A:0.08EU EA WA 824
    rs69395481,2
    A,C109891907(+) AAACAC/TTCACT 1 -- ut310--------
    rs125291351,2
    C,H109893285(+) GACTTG/ATCTTG 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs94871171,2
    F,H109890062(+) ccataC/Taactg 1 -- ng514Minor allele frequency- T:0.01EU EA WA 418
    rs122096911,2
    C,F109893125(+) AAATAC/TTGAGT 1 -- ut31 ese33Minor allele frequency- T:0.28NA 140
    --
    rs123328591,2
    A109891607(+) aatacA/Gcacca 1 -- ut31 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for ZBTB24 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for ZBTB24 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9841 HGNC: 21143 AceView: ZBTB24 Ensembl:ENSG00000112365 euGenes: HUgn9841
    ECgene: ZBTB24 H-InvDB: ZBTB24
    (According to HUGE)
    About This Section

    HUGE: KIAA0441
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB24:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Millipore Custom Antibody & Bulk Services
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     Millipore Immunoassay Services
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     Predesigned and custom siRNAs for ZBTB24 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZBTB24 Browse small molecules at Sigma-Aldrich
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