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Aliases for ZBTB24 Gene

Aliases for ZBTB24 Gene

  • Zinc Finger And BTB Domain Containing 24 2 3
  • Zinc Finger Protein 450 2 3 4
  • ZNF450 3 4 6
  • POZ (BTB) And AT Hook Containing Zinc Finger 2 2 3
  • KIAA0441 4 6
  • PATZ2 3 6
  • ICF2 3 6
  • Zinc Finger And BTB Domain-Containing Protein 24 3
  • BIF1 3

External Ids for ZBTB24 Gene

Previous HGNC Symbols for ZBTB24 Gene

  • ZNF450

Previous GeneCards Identifiers for ZBTB24 Gene

  • GC06M109830
  • GC06M109890
  • GC06M109784
  • GC06M107349

Summaries for ZBTB24 Gene

Entrez Gene Summary for ZBTB24 Gene

  • This gene encodes a protein similar to a protein in rodents which is induced by bone morphogenic protein 2 in vitro. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZBTB24 Gene

ZBTB24 (Zinc Finger And BTB Domain Containing 24) is a Protein Coding gene. Diseases associated with ZBTB24 include immunodeficiency-centromeric instability-facial anomalies syndrome-2 and immunodeficiency, centromere instability and facial anomalies syndrome. An important paralog of this gene is ZNF131.

UniProtKB/Swiss-Prot for ZBTB24 Gene

  • May be involved in BMP2-induced transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB24 Gene

Genomics for ZBTB24 Gene

Regulatory Elements for ZBTB24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB24 Gene

109,462,516 bp from pter
109,483,237 bp from pter
20,722 bases
Minus strand

Genomic View for ZBTB24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB24 Gene

Proteins for ZBTB24 Gene

  • Protein details for ZBTB24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 24
    Protein Accession:
    Secondary Accessions:
    • Q17RC6
    • Q5TED5
    • Q8N455

    Protein attributes for ZBTB24 Gene

    697 amino acids
    Molecular mass:
    78282 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA23713.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB24 Gene


neXtProt entry for ZBTB24 Gene

Proteomics data for ZBTB24 Gene at MOPED

Post-translational modifications for ZBTB24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB24

No data available for DME Specific Peptides for ZBTB24 Gene

Domains for ZBTB24 Gene

Suggested Antigen Peptide Sequences for ZBTB24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 A.T hook DNA-binding domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
  • Contains 1 A.T hook DNA-binding domain.
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB24: view

Function for ZBTB24 Gene

Molecular function for ZBTB24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in BMP2-induced transcription.

Gene Ontology (GO) - Molecular Function for ZBTB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB24: view

Animal Model Products

miRNA for ZBTB24 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB24 Gene

Localization for ZBTB24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB24 Gene

Subcellular locations from

Jensen Localization Image for ZBTB24 Gene COMPARTMENTS Subcellular localization image for ZBTB24 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZBTB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB24: view

Pathways for ZBTB24 Gene

SuperPathways for ZBTB24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB24: view

No data available for Pathways by source for ZBTB24 Gene

Transcripts for ZBTB24 Gene

mRNA/cDNA for ZBTB24 Gene

Unigene Clusters for ZBTB24 Gene

Zinc finger and BTB domain containing 24:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB24

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -

Relevant External Links for ZBTB24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB24 Gene

mRNA expression in normal human tissues for ZBTB24 Gene

Protein differential expression in normal tissues for ZBTB24 Gene

This gene is overexpressed in Lung (61.1) and Blymphocyte (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB24 Gene

SOURCE GeneReport for Unigene cluster for ZBTB24 Gene Hs.409876

mRNA Expression by UniProt/SwissProt for ZBTB24 Gene

Tissue specificity: Widely expressed, with highest levels in naive B-cells.
genes like me logo Genes that share expressions with ZBTB24: view

Expression partners for ZBTB24 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZBTB24 Gene

Orthologs for ZBTB24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZBTB24 35
  • 91.71 (n)
  • 94.25 (a)
ZBTB24 36
  • 93 (a)
(Canis familiaris)
Mammalia ZBTB24 35
  • 88.74 (n)
  • 90.18 (a)
ZBTB24 36
  • 87 (a)
(Mus musculus)
Mammalia Zbtb24 35
  • 84.41 (n)
  • 85.58 (a)
Zbtb24 16
Zbtb24 36
  • 79 (a)
(Pan troglodytes)
Mammalia ZBTB24 35
  • 99.62 (n)
  • 99.57 (a)
ZBTB24 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zbtb24 35
  • 84.61 (n)
  • 86.66 (a)
(Monodelphis domestica)
Mammalia ZBTB24 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB24 36
  • 48 (a)
(Gallus gallus)
Aves ZBTB24 35
  • 72.95 (n)
  • 73.15 (a)
ZBTB24 36
  • 70 (a)
(Anolis carolinensis)
Reptilia ZBTB24 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16056 35
zbtb24 35
  • 64.15 (n)
  • 60.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7636 35
(Danio rerio)
Actinopterygii zbtb24 35
  • 59 (n)
  • 53.98 (a)
zbtb24 36
  • 45 (a)
zbtb24 36
  • 46 (a)
Species with no ortholog for ZBTB24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB24 Gene

Gene Tree for ZBTB24 (if available)
Gene Tree for ZBTB24 (if available)

Paralogs for ZBTB24 Gene

Paralogs for ZBTB24 Gene

(9) SIMAP similar genes for ZBTB24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB24: view

Variants for ZBTB24 Gene

Sequence variations from dbSNP and Humsavar for ZBTB24 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2227263 -- 109,481,448(-) GTTCA(A/G)AATAG synonymous-codon, reference
rs2232441 -- 109,477,080(-) TTCCA(A/G)AATTT intron-variant
rs2232442 -- 109,477,013(-) AAAAT(A/C)CTTTA intron-variant
rs2232443 -- 109,475,609(-) TGAAA(A/G)AATTT intron-variant
rs2232444 -- 109,475,364(-) TACAC(A/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB24 Gene

Variant ID Type Subtype PubMed ID
nsv510045 CNV Loss 20534489

Relevant External Links for ZBTB24 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB24 Gene

Disorders for ZBTB24 Gene

(1) OMIM Diseases for ZBTB24 Gene (614064)


  • Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2) [MIM:614069]: A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients. {ECO:0000269 PubMed:21596365}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZBTB24

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZBTB24: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZBTB24 Gene

Publications for ZBTB24 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. (PMID: 21596365) de Greef J.C. … van der Maarel S.M. (Am. J. Hum. Genet. 2011) 3 4

Products for ZBTB24 Gene

Sources for ZBTB24 Gene

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