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Aliases for ZBTB24 Gene

Aliases for ZBTB24 Gene

  • Zinc Finger And BTB Domain Containing 24 2 3 5
  • Zinc Finger Protein 450 2 3 4
  • POZ (BTB) And AT Hook Containing Zinc Finger 2 2 3
  • ZNF450 3 4
  • KIAA0441 4
  • PATZ2 3
  • BIF1 3
  • ICF2 3

External Ids for ZBTB24 Gene

Previous HGNC Symbols for ZBTB24 Gene

  • ZNF450

Previous GeneCards Identifiers for ZBTB24 Gene

  • GC06M109830
  • GC06M109890
  • GC06M109784
  • GC06M107349

Summaries for ZBTB24 Gene

Entrez Gene Summary for ZBTB24 Gene

  • This gene encodes a protein similar to a protein in rodents which is induced by bone morphogenic protein 2 in vitro. [provided by RefSeq, Aug 2011]

GeneCards Summary for ZBTB24 Gene

ZBTB24 (Zinc Finger And BTB Domain Containing 24) is a Protein Coding gene. Diseases associated with ZBTB24 include Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome-2 and Immunodeficiency, Centromere Instability And Facial Anomalies Syndrome. An important paralog of this gene is ZNF131.

UniProtKB/Swiss-Prot for ZBTB24 Gene

  • May be involved in BMP2-induced transcription.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB24 Gene

Genomics for ZBTB24 Gene

Regulatory Elements for ZBTB24 Gene

Enhancers for ZBTB24 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZBTB24 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB24 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB24 Gene

Chromosome:
6
Start:
109,462,516 bp from pter
End:
109,483,237 bp from pter
Size:
20,722 bases
Orientation:
Minus strand

Genomic View for ZBTB24 Gene

Genes around ZBTB24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB24 Gene

Proteins for ZBTB24 Gene

  • Protein details for ZBTB24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43167-ZBT24_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 24
    Protein Accession:
    O43167
    Secondary Accessions:
    • Q17RC6
    • Q5TED5
    • Q8N455

    Protein attributes for ZBTB24 Gene

    Size:
    697 amino acids
    Molecular mass:
    78282 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA23713.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB24 Gene

Proteomics data for ZBTB24 Gene at MOPED

Post-translational modifications for ZBTB24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ZBT24
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB24

No data available for DME Specific Peptides for ZBTB24 Gene

Domains & Families for ZBTB24 Gene

Gene Families for ZBTB24 Gene

Suggested Antigen Peptide Sequences for ZBTB24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43167

UniProtKB/Swiss-Prot:

ZBT24_HUMAN :
  • Contains 1 A.T hook DNA-binding domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
Domain:
  • Contains 1 A.T hook DNA-binding domain.
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB24: view

Function for ZBTB24 Gene

Molecular function for ZBTB24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in BMP2-induced transcription.
genes like me logo Genes that share phenotypes with ZBTB24: view

Human Phenotype Ontology for ZBTB24 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZBTB24 Gene

MGI Knock Outs for ZBTB24:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for ZBTB24 Gene

Localization for ZBTB24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB24 Gene COMPARTMENTS Subcellular localization image for ZBTB24 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZBTB24 Gene

Pathways & Interactions for ZBTB24 Gene

SuperPathways for ZBTB24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB24 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBTB24 Gene

Drugs & Compounds for ZBTB24 Gene

No Compound Related Data Available

Transcripts for ZBTB24 Gene

mRNA/cDNA for ZBTB24 Gene

Unigene Clusters for ZBTB24 Gene

Zinc finger and BTB domain containing 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for ZBTB24 Gene

GeneLoc Exon Structure for
ZBTB24
ECgene alternative splicing isoforms for
ZBTB24

Expression for ZBTB24 Gene

mRNA expression in normal human tissues for ZBTB24 Gene

Protein differential expression in normal tissues from HIPED for ZBTB24 Gene

This gene is overexpressed in Lung (61.1) and Blymphocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB24 Gene



SOURCE GeneReport for Unigene cluster for ZBTB24 Gene Hs.409876

mRNA Expression by UniProt/SwissProt for ZBTB24 Gene

O43167-ZBT24_HUMAN
Tissue specificity: Widely expressed, with highest levels in naive B-cells.
genes like me logo Genes that share expression patterns with ZBTB24: view

Protein tissue co-expression partners for ZBTB24 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZBTB24 Gene

Orthologs for ZBTB24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB24 35
  • 91.71 (n)
  • 94.25 (a)
ZBTB24 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB24 35
  • 88.74 (n)
  • 90.18 (a)
ZBTB24 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb24 35
  • 84.41 (n)
  • 85.58 (a)
Zbtb24 16
Zbtb24 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB24 35
  • 99.62 (n)
  • 99.57 (a)
ZBTB24 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb24 35
  • 84.61 (n)
  • 86.66 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB24 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB24 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB24 35
  • 72.95 (n)
  • 73.15 (a)
ZBTB24 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB24 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16056 35
zbtb24 35
  • 64.15 (n)
  • 60.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7636 35
zebrafish
(Danio rerio)
Actinopterygii zbtb24 35
  • 59 (n)
  • 53.98 (a)
zbtb24 36
  • 45 (a)
OneToMany
zbtb24 36
  • 46 (a)
OneToMany
Species with no ortholog for ZBTB24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB24 Gene

ENSEMBL:
Gene Tree for ZBTB24 (if available)
TreeFam:
Gene Tree for ZBTB24 (if available)

Paralogs for ZBTB24 Gene

Paralogs for ZBTB24 Gene

(9) SIMAP similar genes for ZBTB24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB24: view

Variants for ZBTB24 Gene

Sequence variations from dbSNP and Humsavar for ZBTB24 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_057458 -
VAR_065846 Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2)
rs5879027 -- 109,475,044(+) CTTTA(-/A)AAAAA intron-variant
rs6568576 -- 109,471,879(+) AGCAG(A/G)AGGGC intron-variant
rs6900926 -- 109,470,088(+) CTGGA(C/T)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB24 Gene

Variant ID Type Subtype PubMed ID
nsv510045 CNV Loss 20534489

Variation tolerance for ZBTB24 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB24 Gene

Human Gene Mutation Database (HGMD)
ZBTB24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB24 Gene

Disorders for ZBTB24 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZBTB24 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency-centromeric instability-facial anomalies syndrome-2
  • immunodeficiency-centromeric instability-facial anomalies syndrome 2
immunodeficiency, centromere instability and facial anomalies syndrome
  • icf syndrome
granulomatous hepatitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZBT24_HUMAN
  • Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2) [MIM:614069]: A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients. {ECO:0000269 PubMed:21596365}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZBTB24

Genetic Association Database (GAD)
ZBTB24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB24
genes like me logo Genes that share disorders with ZBTB24: view

No data available for Genatlas for ZBTB24 Gene

Publications for ZBTB24 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ZBTB24 Gene

Sources for ZBTB24 Gene

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