ZBTB24 Gene
protein-coding GIFtS: 49
GCID: GC06M109784
|
|
zinc finger and BTB domain containing 24(Previous name: zinc finger protein 450 )
(Previous symbol: ZNF450)
| |
Aliases
for ZBTB24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 241 2 | | KIAA04411 3 | | Zinc Finger Protein 4501 2 3 | | ICF22 | | ZNF4501 2 3 | | POZ (BTB) And AT Hook Containing Zinc Finger 22 | | BIF11 2 | | Zinc Finger And BTB Domain-Containing Protein 242 | | PATZ21 2 | | |
Export aliases for ZBTB24 gene to outside databasesPrevious GC identifers: GC06M109830 GC06M109890 GC06M107349 |
Summaries
for ZBTB24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ZBTB24:
This gene encodes a protein similar to a protein in rodents which is induced by bone morphogenic protein 2 in vitro.(provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167Function: May be involved in BMP2-induced transcription (By similarity)
|
Genomic Views
for ZBTB24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB24 gene promoter:
HOXA9B HOXA9 SRF SRF (504 AA) POU3F2 (N-Oct-5a) POU3F2 Meis-1b CREB deltaCREB Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21ZBTB24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M109784: view genomic region
(about GC identifiers)
Start:
|
109,783,719 bp from pter |
End:
|
109,804,440 bp from pter |
Size:
|
20,722 bases |
Orientation:
|
minus strand |
|
Proteins
for ZBTB24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 24 Size: 697 amino acids; 78282 Da
Subcellular location: Nucleus (Potential)
Developmental stage: Regulated expression during B-cell differentiation. Low expression in pro-B cells, pre-B I cellsand large pre-B II cells. Levels peak in small pre-B II and then slightly decrease in immature B-cells. Low levels inCD34+ umbilical cord blood cells
Sequence caution: Sequence=BAA23713.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q17RC6 Q5TED5 Q8N455Alternative splicing: 2 isoforms: O43167-1 O43167-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZBTB24: NX_O43167
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43167
ZBTB24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001157785.1 NP_055612.2
ENSEMBL proteins: ENSP00000230122
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB24 for ontologies About GeneDecksing
ZBTB24 Antibody Products:
Assay Products for ZBTB24: |
Protein
Domains /
Families
for ZBTB24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB24 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O43167ProtoNet protein and cluster: O43167 2 Blocks protein families: IPB000210 BTB/POZ domain IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 1 A.T hook DNA-binding domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 8 C2H2-type zinc fingers |
Function
for ZBTB24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167Function: May be involved in BMP2-induced transcription (By similarity)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB24 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZBTB24 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZBTB24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB24
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/7 Interacting proteins for ZBTB24 (O431671, 2, 3 ENSP000002301224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB24 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB24
Search CenterWatch for drugs/clinical trials and news about ZBTB24 / ZBT24
|
Transcripts
for ZBTB24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB24 gene (2 alternative transcripts): NM_001164313.1 NM_014797.2 Unigene Cluster for ZBTB24: Zinc finger and BTB domain containing 24 Hs.409876 [show with all ESTs]Unigene Representative Sequence: NM_0147971 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000230122(uc011ear.1 uc010kds.1 uc010kdt.1 uc003ptl.1 uc003ptm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB24 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AB007901.1 AK309697.1 BC036731.1 BC117374.1 BC117376.1 BC143843.1 BX648883.1 3 DOTS entries: DT.213035 DT.75140792 DT.99945138 24/73 AceView cDNA sequences (see all 73): AW204345 BE089355 BU147166 AI373056 AI560841 N28020 AI350628 BF056821 BM719348 AI651469 BX104454 AB007901 AA725796 N24789 AI968019 BM838097 BM834676 AI499916 CF121136 AI350538 CF121174 AW243194 BM831423 BM832246
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB24 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZBTB24
|
Expression
for ZBTB24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCTAGTGG
About this image
See ZBTB24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB24
SOURCE GeneReport for Unigene cluster: Hs.409876
UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167Tissue specificity: Widely expressed, with highest levels in naive B-cells
SABiosciences Custom PCR Arrays for ZBTB24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB24
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB24 |
Orthologs
for ZBTB24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB24 gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZBTB241 |
zinc finger and BTB domain containing 24 |
72.95(n)
73(a) |
|
421763 XM_419793.3 XP_419793.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB246 |
-- |
65(a) |
1 ↔ 1 |
1(191154417-191162188) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.76362 |
Xenopus laevis transcribed sequence with weak similarity more |
74.52(n) |
|
BX846468.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zbtb241 |
zinc finger and BTB domain containing 24 |
58.31(n)
52.28(a) |
|
553955 NM_001023572.1 NP_001018866.1 |
ENSEMBL Gene Tree for ZBTB24 (if available)
TreeFam Gene Tree for ZBTB24 (if available) |
Paralogs
for ZBTB24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB24 gene
- ZBTB102 ZBTB32 ZBTB182 ZBTB8A2 ZBTB442 ZBTB52 ENSG000002545532 HIC12
- ZBTB492 ZBTB422 GZF12 HIC22 MYNN2 ZBTB462 ZBTB8B2 ZBTB172
8 SIMAP similar genes for ZBTB24 using alignment to 1 protein entry: ZBT24_HUMAN:ZNF589 ZNF501 ZNF514 ZNF669 ZNF419 ZNF80
ZNF561 MYNN
ZBTB24 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB24 (109783719 - 109804440 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB24: --
Human Gene Mutation Database (HGMD): ZBTB24
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB24 |
|
Disorders
/ Diseases
for ZBTB24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB24 for disorders About GeneDecksing
OMIM gene information: 614064
OMIM disorders: --
UniProtKB/Swiss-Prot: ZBT24_HUMAN, O43167
Defects in ZBTB24 are the cause of immunodeficiency-centromeric instability-facial anomalies syndrome type 2(ICF2) [MIM:614069]. A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections,facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation,failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a smallfraction of the genome in some, but not all, patients
3  diseases for ZBTB24: About MalaCardsimmunodeficiency-centromeric instability-facial anomalies syndrome immunodeficiency, centromere instability and facial anomalies syndrome immunodeficiency
Export disorders for ZBTB24 gene to outside databases
|
Publications
for ZBTB24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB24 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZBTB24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
- Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. (PubMed id 21596365)1, 2 de Greef J.C.... van der Maarel S.M. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1 Gudbjartsson D.F....Stefansson K. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for ZBTB24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB24 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZBTB24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB24 gene:
Search GeneIP for patents involving ZBTB24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ZBTB24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB24 |
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