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Aliases for ZBTB22 Gene

Aliases for ZBTB22 Gene

  • Zinc Finger And BTB Domain Containing 22 2 3 5
  • Zinc Finger Protein 297 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22A 3 4
  • ZBTB22A 3 4
  • ZNF297 3 4
  • BING1 3 4
  • Protein BING1 4
  • Fruitless 3
  • ZNF297A 3
  • Fru 3

External Ids for ZBTB22 Gene

Previous HGNC Symbols for ZBTB22 Gene

  • ZNF297

Previous GeneCards Identifiers for ZBTB22 Gene

  • GC06M033391
  • GC06M033282
  • GC06M033023

Summaries for ZBTB22 Gene

GeneCards Summary for ZBTB22 Gene

ZBTB22 (Zinc Finger And BTB Domain Containing 22) is a Protein Coding gene. Diseases associated with ZBTB22 include Lobomycosis and Anosognosia. An important paralog of this gene is NACC1.

UniProtKB/Swiss-Prot for ZBTB22 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB22 Gene

Genomics for ZBTB22 Gene

Regulatory Elements for ZBTB22 Gene

Enhancers for ZBTB22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZBTB22 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB22 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB22 Gene

33,314,405 bp from pter
33,317,942 bp from pter
3,538 bases
Minus strand

Genomic View for ZBTB22 Gene

Genes around ZBTB22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZBTB22 Gene

  • Protein details for ZBTB22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 22
    Protein Accession:
    Secondary Accessions:
    • B0V007
    • Q5HYV4
    • Q5STL0
    • Q5STR7
    • Q8WV82

    Protein attributes for ZBTB22 Gene

    634 amino acids
    Molecular mass:
    65602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB22 Gene

Proteomics data for ZBTB22 Gene at MOPED

Post-translational modifications for ZBTB22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB22 Gene

No data available for DME Specific Peptides for ZBTB22 Gene

Domains & Families for ZBTB22 Gene

Gene Families for ZBTB22 Gene

Suggested Antigen Peptide Sequences for ZBTB22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB22: view

Function for ZBTB22 Gene

Molecular function for ZBTB22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZBTB22: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB22 Gene

Localization for ZBTB22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB22 Gene

Subcellular locations from

Jensen Localization Image for ZBTB22 Gene COMPARTMENTS Subcellular localization image for ZBTB22 gene
Compartment Confidence
nucleus 5
chloroplast 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ZBTB22 Gene

Pathways & Interactions for ZBTB22 Gene

SuperPathways for ZBTB22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB22 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZBTB22 Gene

Drugs & Compounds for ZBTB22 Gene

(1) Drugs for ZBTB22 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 1059
genes like me logo Genes that share compounds with ZBTB22: view

Transcripts for ZBTB22 Gene

mRNA/cDNA for ZBTB22 Gene

Unigene Clusters for ZBTB22 Gene

Zinc finger and BTB domain containing 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB22 Gene

No ASD Table

Relevant External Links for ZBTB22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB22 Gene

mRNA expression in normal human tissues for ZBTB22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB22 Gene

SOURCE GeneReport for Unigene cluster for ZBTB22 Gene Hs.206770

genes like me logo Genes that share expression patterns with ZBTB22: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZBTB22 Gene

Orthologs for ZBTB22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZBTB22 35
  • 86.16 (n)
  • 91.44 (a)
ZBTB22 36
  • 93 (a)
(Canis familiaris)
Mammalia ZBTB22 35
  • 88.62 (n)
  • 92.95 (a)
ZBTB22 36
  • 93 (a)
(Mus musculus)
Mammalia Zbtb22 35
  • 83.74 (n)
  • 86.96 (a)
Zbtb22 16
Zbtb22 36
  • 86 (a)
(Pan troglodytes)
Mammalia ZBTB22 35
  • 99.68 (n)
  • 99.53 (a)
ZBTB22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zbtb22 35
  • 83.63 (n)
  • 86.63 (a)
(Monodelphis domestica)
Mammalia ZBTB22 36
  • 84 (a)
(Anolis carolinensis)
Reptilia ZBTB22 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb22 35
  • 65.61 (n)
  • 69.83 (a)
(Danio rerio)
Actinopterygii wufj98b06 35
zbtb22b 35
  • 55.64 (n)
  • 52.42 (a)
ZBTB22 (2 of 2) 36
  • 38 (a)
zbtb22b 36
  • 40 (a)
Species with no ortholog for ZBTB22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB22 Gene

Gene Tree for ZBTB22 (if available)
Gene Tree for ZBTB22 (if available)

Paralogs for ZBTB22 Gene

genes like me logo Genes that share paralogs with ZBTB22: view

Variants for ZBTB22 Gene

Sequence variations from dbSNP and Humsavar for ZBTB22 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_022702 -
VAR_057457 -
rs1065028 -- 33,316,400(-) CTGGG(C/G)TGCCA reference, missense
rs9257105 -- 33,317,502(+) ccccc(-/C/CC/CCC)gtgcc intron-variant
rs13215824 -- 33,317,466(+) cccag(C/T)ttctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB22 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv830635 CNV Loss 17160897

Variation tolerance for ZBTB22 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB22 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB22 Gene

Disorders for ZBTB22 Gene

MalaCards: The human disease database

(13) MalaCards diseases for ZBTB22 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • cutaneous blastomycosis
penis squamous cell carcinoma
  • epidermoid cell carcinoma of penis
granulomatous amebic encephalitis
  • acanthamoeba encephalitis
  • dermatographic urticaria
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZBTB22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZBTB22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB22 Gene

Publications for ZBTB22 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZBTB22 Gene

Sources for ZBTB22 Gene