V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

ZBTB22 Gene

protein-coding   GIFtS: 49

GC06M033391
zinc finger and BTB domain containing 22
(Previous name: zinc finger protein 297 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF297)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
BING1 1, 2, 3
OTTHUMP00000029145 2
ZBTB22A 1, 2, 3
ZNF297 2, 3
ZNF297A 1, 2
fru 1, 2
fruitless 1, 2
Descriptions
Protein BING1 3
Zinc finger and BTB domain-containing protein 22A 3
Zinc finger protein 297 1, 2, 3
zinc finger and BTB domain containing 22 2
External Ids
HGNC: 130851
Entrez Gene: 92782
UniProtKB: O152093
Ensembl: ENSG000002042107
Search outside databases for aliases for ZBTB22 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT22_HUMAN, O15209
Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB22 gene  

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

ZBTB22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033391:     (about GC identifiers)

Start:
33,390,173 bp from pter
End:
33,393,488 bp from pter
Size:
3,316 bases
Orientation:
minus strand

2 alternative locations:
Chr6-,c6_COX 33,350,877-33,354,179      Chr6-,c6_QBL 33,353,897-33,357,197     
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  NT_113891.1  NT_113897.1  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT22_HUMAN, O15209 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 22  
Size: 634 amino acids; 65602 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q5HYV4 Q5STL0 Q5STR7 Q8WV82

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001138810.1  NP_005444.4  


    ENSEMBL proteins: 
    ENSP00000363682 ENSP00000363684 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZBTB22)
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: ZBTB22 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus TAS9545376
    About this table

    Antibodies for ZBTB22: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB22
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZBTB22), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ZNF297)
    Novus Biologicals Antibody for ZBTB22

    Assays for ZBTB22: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB22 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O15209

    ProtoNet protein and cluster: O15209

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZBT22_HUMAN, O15209
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 3 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB22)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZNF297)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001145338

                  Applied Biosystems Silencer® siRNAs for ZBTB22

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB22  
                         Sigma-Aldrich shRNA for ZBTB22  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZBTB22
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145338
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145338
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145338 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005453

    UniProtKB/Swiss-Prot: ZBT22_HUMAN, O15209
    Function: May be involved in transcriptional regulation

    1 MGI phenotypic allele for Zbtb22 (no phenotypes)


    5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding TAS9545376
    GO:0004886 retinoid-X receptor activity IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0030375 thyroid hormone receptor coactivator activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for ZBTB22 (O152092) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJA3Q96EY12MINT-68242
    --Q5VYA02MINT-63095
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB22

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB22)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZNF297)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001145338

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB22  
                         Sigma-Aldrich shRNA for ZBTB22  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005453  

    REFSEQ mRNAs for ZBTB22 gene (2 alternative transcripts): 

    NM_001145338.1   NM_005453.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005453  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145338
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145338
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145338 

    Additional cDNA sequence: 

    AK095978.1 AK315747.1 BC018541.1 

    3 DOTS entries:

    DT.415643  DT.100022139  DT.121329634 

    24/103 AceView cDNA sequences (see all 103 ):

    BC018541 CB850958 BU902484 AA776298 CF265020 BM723573 BQ218938 BX463591 
    NM_005453 BM722936 BQ002626 AA455280 AI033861 AW087693 AA309450 AL565421 
    AL523145 BU676578 AK095978 BG820461 W94380 BE677601 BP356814 D82810 

    highest scoring ESTs for ZBTB22:

    AI884738 AL523145 BC018541 BG107129 BG820461 BI754387 BI821443 BI827966 BU520918 BX442464 

    Unigene Cluster for ZBTB22:

    Zinc finger and BTB domain containing 22
    Hs.206770  [show with all ESTs]
    Unigene Representative Sequence: NM_005453


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000374554  ENST00000374556  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB22 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB22

    1 / 2 / 3

    4 probe-sets matching ZBTB22 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    34179_at2, 3 U95-A 3 1.00 0.33 0.88 0.86 Z97183 0.20 1.00 0.72 1
    34178_at2, 3 U95-A 3 1.00 0.33 0.34 1.14 AI884738 0.80 1.00 0.91 1

    213081_at2, 3 U133-A 3 1.00 0.33 -- -- AL523144 0.60 1.00 0.82 1

    213081_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --
    GeneDecks  ZBTB22 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGGAGTGGG

    SOURCE GeneReport for Unigene cluster: Hs.206770
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB22 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB221   -- zinc finger and BTB domain containing 22 89.15(n)
    93.68(a)
    607900  XM_844748.1  XP_849841.1 
    chimpanzee
    (Pan troglodytes)
    ZBTB221   -- zinc finger and BTB domain containing 22 99.74(n)
    99.68(a)
    462611  XM_001170844.1  XP_001170844.1 
    cow
    (Bos taurus)
    ZBTB221   -- zinc finger and BTB domain containing 22 87.74(n)
    93.34(a)
    538456  XM_580440.3  XP_580440.3 
    rat
    (Rattus norvegicus)
    Zbtb221   -- zinc finger and BTB domain containing 22 84.15(n)
    87.12(a)
    309630  NM_001009172.2  NP_001009172.1 
    mouse
    (Mus musculus)
    Zbtb221, 5 175
    zinc finger and BTB domain containing 221, 5 84(n)1
    87.6(a)1
    816301  NM_020625.21  NP_065650.11 
     AF1009565  AI2652105  (see all 16)
    About this table        Species with no ortholog for ZBTB22

    ENSEMBL Gene Tree for ZBTB22
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB22 gene
    ZBTB342  ZBTB92  ZBTB372  ZBTB432  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10 NCBI SNPs in ZBTB22 are shown
    (Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs69405581,2
    A33393853(+) CCTTTC/TTCCGG 1 -- ng31 trp30--------
    rs10650281,2
    --33392155(-) CTGGGC/GTGCCA 1 V/L mis10--------
    --
    rs359582991,2
    --33392683(+) AGGGA-/GGGGGA 1 -- ut510--------
    rs356587491,2
    --33392222(+) GCCCGG/CCCTTC 1 G/G syn11Minor allele frequency- C:0.01NA 74
    --
    rs342975721,2
    --33393254(+) CCCCC-/CCCCGT 1 -- int10--------
    --
    rs132158241,2
    --33393221(+) cccagC/Tttctc 1 -- int10--------
    --
    rs92779731,2
    --33393240(+) cccctC/Ttccag 1 -- int10--------
    --
    rs349929161,2
    --33393171(+) CCTCA-/GGGCTA 1 -- int10--------
    --
    rs113457881,2
    --33393250(+) GCCCA-/CCCCCC 1 -- int10--------
    --
    rs723921381,2
    --33393251(+) CCCAC-/CCCCCCC 1 -- int10--------
    About this table
    The following additional 49 SNP(s) have been found in Applied Biosystems data source:
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)


     rs763122 rs1061803 rs3106189 rs1800838 rs3106194 rs12528161 rs3130018
     rs11969555 rs9277972 rs1802272 rs1061798 rs35663442 rs2051625 rs2073524
     rs1800837 rs61737694 rs6902291 rs28724911 rs3106191 rs41266737 rs2187889
     rs496581 rs3748082 rs2282851 rs61739590 rs3130100 rs1061801 rs35022604
     rs34349100 rs11873 rs1801850 rs3173271 rs4573121 rs1061783 rs4713617
     rs9296091 rs9469398 rs1801849 rs61734030 rs3106190 rs2239839 rs2073525
     rs11966917 rs2269610 rs12664430 rs3130099 rs11969475 rs1059231 rs2071888

    HapMap Linkage Disequilibrium images for ZBTB22 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 611439

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for ZBTB22 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9278 HGNC: 13085 AceView: ZNF297 Ensembl:ENSG00000204210 euGenes: HUgn9278
    ECgene: ZBTB22 H-InvDB: ZBTB22
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB22:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB22-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB22 Antibodies for ZBTB22
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZBTB22 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Antibodies (ZNF297)
     Chimera RNAi (ZNF297)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (ZBTB22)
     Antibodies (ZBTB22)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for ZBTB22




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ZBTB22

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    ZBTB22 Gene at Home site.
    Version 2.41.1
    server4.xennexinc.com