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Aliases for ZBTB22 Gene

Aliases for ZBTB22 Gene

  • Zinc Finger And BTB Domain Containing 22 2 3
  • Zinc Finger Protein 297 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22A 3 4
  • ZBTB22A 3 4
  • ZNF297 3 4
  • BING1 3 4
  • Protein BING1 4
  • Fruitless 3
  • ZNF297A 3
  • Fru 3

External Ids for ZBTB22 Gene

Previous HGNC Symbols for ZBTB22 Gene

  • ZNF297

Previous GeneCards Identifiers for ZBTB22 Gene

  • GC06M033391
  • GC06M033282
  • GC06M033023

Summaries for ZBTB22 Gene

GeneCards Summary for ZBTB22 Gene

ZBTB22 (Zinc Finger And BTB Domain Containing 22) is a Protein Coding gene. Diseases associated with ZBTB22 include lobomycosis and anosognosia. An important paralog of this gene is NACC2.

UniProtKB/Swiss-Prot for ZBTB22 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB22 Gene

Genomics for ZBTB22 Gene

Regulatory Elements for ZBTB22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB22 Gene

Chromosome:
6
Start:
33,314,405 bp from pter
End:
33,317,942 bp from pter
Size:
3,538 bases
Orientation:
Minus strand

Genomic View for ZBTB22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZBTB22 Gene

  • Protein details for ZBTB22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15209-ZBT22_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 22
    Protein Accession:
    O15209
    Secondary Accessions:
    • B0V007
    • Q5HYV4
    • Q5STL0
    • Q5STR7
    • Q8WV82

    Protein attributes for ZBTB22 Gene

    Size:
    634 amino acids
    Molecular mass:
    65602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB22 Gene

Proteomics data for ZBTB22 Gene at MOPED

Post-translational modifications for ZBTB22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB22 Gene

No data available for DME Specific Peptides for ZBTB22 Gene

Domains & Families for ZBTB22 Gene

Suggested Antigen Peptide Sequences for ZBTB22 Gene

Graphical View of Domain Structure for InterPro Entry

O15209

UniProtKB/Swiss-Prot:

ZBT22_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB22: view

Function for ZBTB22 Gene

Molecular function for ZBTB22 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

Phenotypes for ZBTB22 Gene

GenomeRNAi human phenotypes for ZBTB22:
genes like me logo Genes that share phenotypes with ZBTB22: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB22 Gene

Localization for ZBTB22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB22 Gene COMPARTMENTS Subcellular localization image for ZBTB22 gene
Compartment Confidence
nucleus 4
chloroplast 2
cytosol 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

Pathways & Interactions for ZBTB22 Gene

SuperPathways for ZBTB22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB22 Gene

Drugs & Compounds for ZBTB22 Gene

(1) Drugs for ZBTB22 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 971
genes like me logo Genes that share compounds with ZBTB22: view

Transcripts for ZBTB22 Gene

mRNA/cDNA for ZBTB22 Gene

Unigene Clusters for ZBTB22 Gene

Zinc finger and BTB domain containing 22:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB22 Gene

No ASD Table

Relevant External Links for ZBTB22 Gene

GeneLoc Exon Structure for
ZBTB22
ECgene alternative splicing isoforms for
ZBTB22

Expression for ZBTB22 Gene

mRNA expression in normal human tissues for ZBTB22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB22 Gene



SOURCE GeneReport for Unigene cluster for ZBTB22 Gene Hs.206770

genes like me logo Genes that share expression patterns with ZBTB22: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZBTB22 Gene

Orthologs for ZBTB22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB22 35
  • 86.16 (n)
  • 91.44 (a)
ZBTB22 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB22 35
  • 88.62 (n)
  • 92.95 (a)
ZBTB22 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb22 35
  • 83.74 (n)
  • 86.96 (a)
Zbtb22 16
Zbtb22 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB22 35
  • 99.68 (n)
  • 99.53 (a)
ZBTB22 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb22 35
  • 83.63 (n)
  • 86.63 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB22 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB22 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb22 35
  • 65.61 (n)
  • 69.83 (a)
zebrafish
(Danio rerio)
Actinopterygii wufj98b06 35
zbtb22b 35
  • 55.64 (n)
  • 52.42 (a)
ZBTB22 (2 of 2) 36
  • 38 (a)
OneToMany
zbtb22b 36
  • 40 (a)
OneToMany
Species with no ortholog for ZBTB22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB22 Gene

ENSEMBL:
Gene Tree for ZBTB22 (if available)
TreeFam:
Gene Tree for ZBTB22 (if available)

Paralogs for ZBTB22 Gene

genes like me logo Genes that share paralogs with ZBTB22: view

Variants for ZBTB22 Gene

Sequence variations from dbSNP and Humsavar for ZBTB22 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs532543374 -- 33,317,495(+) GCCCA(-/C)CCCCC intron-variant
VAR_022702 -
VAR_057457 -

Structural Variations from Database of Genomic Variants (DGV) for ZBTB22 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv830635 CNV Loss 17160897

Variation tolerance for ZBTB22 Gene

Residual Variation Intolerance Score: 45.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB22 Gene

HapMap Linkage Disequilibrium report
ZBTB22
Human Gene Mutation Database (HGMD)
ZBTB22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB22 Gene

Disorders for ZBTB22 Gene

MalaCards: The human disease database

(12) MalaCards diseases for ZBTB22 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lobomycosis
  • cutaneous lobomycosis
anosognosia
penis squamous cell carcinoma
  • epidermoid cell carcinoma of penis
dermatographia
  • dermatographic urticaria
calcific tendinitis
- elite association

Relevant External Links for ZBTB22

Genetic Association Database (GAD)
ZBTB22
Human Genome Epidemiology (HuGE) Navigator
ZBTB22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB22
genes like me logo Genes that share disorders with ZBTB22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBTB22 Gene

Publications for ZBTB22 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 67
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for ZBTB22 Gene

Sources for ZBTB22 Gene

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