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Aliases for ZBTB22 Gene

Aliases for ZBTB22 Gene

  • Zinc Finger And BTB Domain Containing 22 2 3
  • Zinc Finger Protein 297 2 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22A 3 4
  • ZBTB22A 3 4
  • ZNF297 3 4
  • BING1 3 4
  • Zinc Finger And BTB Domain-Containing Protein 22 3
  • Protein BING1 4
  • Fruitless 3
  • ZNF297A 3
  • Fru 3

External Ids for ZBTB22 Gene

Previous Symbols for ZBTB22 Gene

  • ZNF297

Summaries for ZBTB22 Gene

GeneCards Summary for ZBTB22 Gene

ZBTB22 (Zinc Finger And BTB Domain Containing 22) is a Protein Coding gene. An important paralog of this gene is NACC2.

UniProtKB/Swiss-Prot for ZBTB22 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB22 Gene

Genomics for ZBTB22 Gene

Genomic Location for ZBTB22 Gene

33,314,405 bp from pter
33,317,942 bp from pter
3,538 bases
Minus strand

Genomic View for ZBTB22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for ZBTB22 Gene

Proteins for ZBTB22 Gene

  • Protein details for ZBTB22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 22
    Protein Accession:
    Secondary Accessions:
    • B0V007
    • Q5HYV4
    • Q5STL0
    • Q5STR7
    • Q8WV82

    Protein attributes for ZBTB22 Gene

    634 amino acids
    Molecular mass:
    65602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB22 Gene

Proteomics data for ZBTB22 Gene at MOPED

Post-translational modifications for ZBTB22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB22 Gene

No data available for DME Specific Peptides for ZBTB22 Gene

Domains for ZBTB22 Gene

Gene Families for ZBTB22 Gene

  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing


  • Contains 1 BTB (POZ) domain.:
    • O15209
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • O15209
  • Contains 3 C2H2-type zinc fingers.:
    • O15209
genes like me logo Genes that share domains with ZBTB22: view

Function for ZBTB22 Gene

Molecular function for ZBTB22 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

miRNA for ZBTB22 Gene

miRTarBase miRNAs that target ZBTB22

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB22 Gene

Localization for ZBTB22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB22 Gene

Subcellular locations from

Jensen Localization Image for ZBTB22 Gene COMPARTMENTS Subcellular localization image for ZBTB22 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

Pathways for ZBTB22 Gene

SuperPathways for ZBTB22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB22: view

No data available for Pathways by source for ZBTB22 Gene

Transcripts for ZBTB22 Gene

mRNA/cDNA for ZBTB22 Gene

Unigene Clusters for ZBTB22 Gene

Zinc finger and BTB domain containing 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB22 Gene

No ASD Table

Relevant External Links for ZBTB22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB22 Gene

mRNA expression in normal human tissues for ZBTB22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB22 Gene

SOURCE GeneReport for Unigene cluster for ZBTB22 Gene Hs.206770

genes like me logo Genes that share expressions with ZBTB22: view

Orthologs for ZBTB22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB22 36
  • 99.68 (n)
  • 99.53 (a)
ZBTB22 37
  • 100 (a)
(Bos Taurus)
Mammalia ZBTB22 36
  • 86.16 (n)
  • 91.44 (a)
ZBTB22 37
  • 93 (a)
(Canis familiaris)
Mammalia ZBTB22 36
  • 88.62 (n)
  • 92.95 (a)
ZBTB22 37
  • 93 (a)
(Mus musculus)
Mammalia Zbtb22 36
  • 83.74 (n)
  • 86.96 (a)
Zbtb22 16
Zbtb22 37
  • 86 (a)
(Monodelphis domestica)
Mammalia ZBTB22 37
  • 84 (a)
(Rattus norvegicus)
Mammalia Zbtb22 36
  • 83.63 (n)
  • 86.63 (a)
(Anolis carolinensis)
Reptilia ZBTB22 37
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb22 36
  • 65.61 (n)
  • 69.83 (a)
(Danio rerio)
Actinopterygii wufj98b06 36
ZBTB22 (2 of 2) 37
  • 38 (a)
zbtb22b 36
  • 55.64 (n)
  • 52.42 (a)
zbtb22b 37
  • 40 (a)
Species with no ortholog for ZBTB22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB22 Gene

Gene Tree for ZBTB22 (if available)
Gene Tree for ZBTB22 (if available)

Paralogs for ZBTB22 Gene

Selected SIMAP similar genes for ZBTB22 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZBTB22: view

Variants for ZBTB22 Gene

Sequence variations from dbSNP and Humsavar for ZBTB22 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1065028 -- 33,316,400(-) CTGGG(C/G)TGCCA missense, reference
rs9277973 -- 33,317,485(+) cccct(C/T)tccag intron-variant
rs13215824 -- 33,317,466(+) cccag(C/T)ttctc intron-variant
rs34297572 -- 33,317,496(+) CCCCC(-/C)CCCGT intron-variant
rs34992916 -- 33,317,416(+) CCTCA(-/G)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB22 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv830635 CNV Loss 17160897

Relevant External Links for ZBTB22 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ZBTB22 Gene

Relevant External Links for ZBTB22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZBTB22: view

No data available for UniProtKB/Swiss-Prot for ZBTB22 Gene

Publications for ZBTB22 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49
  5. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 3 4

Products for ZBTB22 Gene

Sources for ZBTB22 Gene

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