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ZBTB21 Gene

protein-coding   GIFtS: 45
GCID: GC21M043409

Zinc Finger And BTB Domain Containing 21

(Previous name: zinc finger protein 295)
(Previous symbol: ZNF295)
  Search for ZBTB21
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 211 2
Zinc Finger Protein 2951 2 3
ZNF2951 2 3
Zinc Finger And BTB Domain-Containing Protein 212
KIAA12273

External Ids:    HGNC: 130831   Entrez Gene: 498542   Ensembl: ENSG000001732767   UniProtKB: Q9ULJ33   

Export aliases for ZBTB21 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB21 Gene:
ZBTB21 (zinc finger and BTB domain containing 21) is a protein-coding gene. GO annotations related to this gene include methyl-CpG binding. An important paralog of this gene is ZBTB38.

UniProtKB/Swiss-Prot: ZBT21_HUMAN, Q9ULJ3
Function: Acts as a transcription repressor

Gene Wiki entry for ZBTB21 (ZNF295) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZBTB21
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB21 promoter sequence
   Search Chromatin IP Primers for ZBTB21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

ZBTB21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB21 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M043409:  view genomic region     (about GC identifiers)

Start:
43,406,940 bp from pter      End:
43,430,496 bp from pter
Size:
23,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZBT21_HUMAN, Q9ULJ3 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 21  
Size: 1066 amino acids; 118870 Da
Subunit: Homodimer. Interacts with ZBTB14
Sequence caution: Sequence=BAA86541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ZBTB21:
1WJP (3D)    
Secondary accessions: Q5R2W1 Q5R2W2 Q6P4R0
Alternative splicing: 2 isoforms:  Q9ULJ3-1   Q9ULJ3-2   

Explore the universe of human proteins at neXtProt for ZBTB21: NX_Q9ULJ3

Explore proteomics data for ZBTB21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001091872.1  NP_001091873.1  NP_065778.3  

    ENSEMBL proteins: 
     ENSP00000381517   ENSP00000308759   ENSP00000381512   ENSP00000381523   ENSP00000387788  
     ENSP00000395186   ENSP00000381510  

    ZBTB21 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9ULJ3

    ProtoNet protein and cluster: Q9ULJ3

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT21_HUMAN, Q9ULJ3
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 8 C2H2-type zinc fingers


    Find genes that share domains with ZBTB21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT21_HUMAN, Q9ULJ3
    Function: Acts as a transcription repressor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15629158
    GO:0008327methyl-CpG binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB21           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB21
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    miRTarBase miRNAs that target ZBTB21:
    hsa-mir-425-5p (MIRT039313), hsa-mir-30e-5p (MIRT044137), hsa-mir-186-5p (MIRT021195), hsa-mir-93-5p (MIRT028047), hsa-mir-548b-3p (MIRT016244), hsa-mir-101-3p (MIRT027301), hsa-mir-140-3p (MIRT021681)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT21_HUMAN, Q9ULJ3: Nucleus. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZBTB21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB21
    Interactions:

        Search GeneGlobe Interaction Network for ZBTB21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ZBTB21 (Q9ULJ32, 3 ENSP000003087594) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50788 I2D: score=3 STRING: ENSP00000306330
    ZBTB14O438293, ENSP000003495034I2D: score=1 STRING: ENSP00000349503
    PPP2R2BQ000053, ENSP000003365914I2D: score=2 STRING: ENSP00000336591
    RFC1ENSP000002614244STRING: ENSP00000261424
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA15629158

    Find genes that share ontologies with ZBTB21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB21 (ZBT21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBTB21 gene (3 alternative transcripts): 
    NM_001098402.1  NM_001098403.1  NM_020727.4  

    Unigene Cluster for ZBTB21:

    Zinc finger and BTB domain containing 21
    Hs.434947  [show with all ESTs]
    Unigene Representative Sequence: NM_001098402
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398505(uc002yzz.4) ENST00000310826(uc002zab.4 uc002yzy.4 uc002zaa.4)
    ENST00000398499(uc010gov.1 uc002zac.2) ENST00000398511 ENST00000465968
    ENST00000425521 ENST00000449949 ENST00000398497
    miRNA
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    OriGene qPCR primer pairs and template standards for ZBTB21
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      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB21
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB21

    Additional mRNA sequence: 

    AB033053.1 AB041014.1 AB041015.1 AB190372.1 AB190373.1 AB190374.1 AK300291.1 AK308179.1 
    BC063290.1 CR933655.1 

    9 DOTS entries:

    DT.210935  DT.100751524  DT.95269309  DT.121137258  DT.121137222  DT.100799862  DT.427295  DT.427296 
    DT.91649658 

    Selected AceView cDNA sequences (see all 110):

    BM967232 AI004962 BF061614 AW675442 CD677527 AV719921 AB033053 CR594540 
    NM_020727 AW269321 BE218440 AA023010 AI383632 AI338498 BX499889 BU177228 
    CR610383 BQ129301 H85897 BM511641 CB990284 AI094473 BG620908 AL544048 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZBTB21 Expression
    About this image


    ZBTB21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    ZBTB21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434947

    UniProtKB/Swiss-Prot: ZBT21_HUMAN, Q9ULJ3
    Tissue specificity: Ubiquitous in fetal and adult tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB21 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb211 , 5 zinc finger protein 2955
    zinc finger and BTB domain containing 211
    83.04(n)1
    86.83(a)1
      16 (57.75 cM)5
    1145651  NM_175428.31  NP_780637.21 
     979474355 
    chicken
    (Gallus gallus)
    Aves ZNF2951 zinc finger protein 295 76.59(n)
    81.52(a)
      427986  XM_004934576.1  XP_004934633.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB216
    zinc finger and BTB domain containing 21
    76(a)
    1 ↔ 1
    3(138069642-138072773)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204112 Transcribed sequence with moderate similarity to protein more 74.17(n)    AL886487.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb211 zinc finger and BTB domain containing 21 58.94(n)
    56.97(a)
      566813  XM_690101.5  XP_695193.6 


    ENSEMBL Gene Tree for ZBTB21 (if available)
    TreeFam Gene Tree for ZBTB21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB21 gene
    ZBTB382  ZBTB332  ZBTB142  ZBTB7C2  ZBTB7A2  ZBTB7B2  ZBTB42  
    Selected SIMAP similar genes for ZBTB21 using alignment to 2 protein entries:     ZBT21_HUMAN (see all proteins) (see all similar genes):
    DKFZp781N1974    ZNF295    ZBTB4    ZBTB7C    KLHL7    ZBTB47
    KLHL36    ZBTB38    ZBTB49    ZBTB14    KLHL28    MYNN
    HIC1    BACH2    BCL6    Bach2    KLHL10    NACC1

    Find genes that share paralogs with ZBTB21           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB21 (see all 693)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477184511,2
    C--43406504(+) AAAAAC/TGATAT 3 -- ds50010--------
    rs1409916081,2
    C--43406560(+) TATGAC/TATTAA 3 -- ds50010--------
    rs3908531,2
    C,F,O,A,H--43406577(+) TAGATT/AATCAA 3 -- ds500117Minor allele frequency- A:0.27NA NS EA WA CSA 827
    rs1856361911,2
    --43406609(+) CTATGC/TAGAAA 3 -- ds50010--------
    rs3976631,2
    C,F,A,H--43406657(+) ATTTAC/GCCCCC 3 -- ds500113Minor allele frequency- G:0.24NS EA NA WA CSA 756
    rs1181781721,2
    F--43406750(+) TCATCG/ATATTT 3 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1497873041,2
    C--43406759(+) TTGCGA/GTGCCC 3 -- ds50010--------
    rs1171435631,2
    F--43406794(+) CTTAAT/GTCTAT 3 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1899967131,2
    --43406807(+) GCAACC/GTGGAA 3 -- ds50010--------
    rs1825712621,2
    --43406894(+) AATGCC/TACACC 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZBTB21 (43406940 - 43430496 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZBTB21: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB21
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB21 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ZBTB21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. (PubMed id 15629158)1, 2, 9 Wang J.... Shimizu N. (Biochem. Biophys. Res. Commun. 2005)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 49854 HGNC: 13083 AceView: ZNF295 Ensembl:ENSG00000173276 euGenes: HUgn49854
    ECgene: ZBTB21 H-InvDB: ZBTB21

    (According to HUGE)
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    HUGE: KIAA1227

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZBTB21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZBTB21 gene:
    Search GeneIP for patents involving ZBTB21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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