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Aliases for ZBTB21 Gene

Aliases for ZBTB21 Gene

  • Zinc Finger And BTB Domain Containing 21 2 3
  • Zinc Finger Protein 295 2 3 4
  • ZNF295 3 4
  • Zinc Finger And BTB Domain-Containing Protein 21 3
  • KIAA1227 4

External Ids for ZBTB21 Gene

Previous Symbols for ZBTB21 Gene

  • ZNF295

Summaries for ZBTB21 Gene

GeneCards Summary for ZBTB21 Gene

ZBTB21 (Zinc Finger And BTB Domain Containing 21) is a Protein Coding gene. GO annotations related to this gene include methyl-CpG binding. An important paralog of this gene is ZBTB7B.

UniProtKB/Swiss-Prot for ZBTB21 Gene

  • Acts as a transcription repressor.

Gene Wiki entry for ZBTB21 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB21 Gene

Genomics for ZBTB21 Gene

Genomic Location for ZBTB21 Gene

Start:
41,986,831 bp from pter
End:
42,010,387 bp from pter
Size:
23,557 bases
Orientation:
Minus strand

Genomic View for ZBTB21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB21 Gene

No data available for Regulatory Elements for ZBTB21 Gene

Proteins for ZBTB21 Gene

  • Protein details for ZBTB21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULJ3-ZBT21_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 21
    Protein Accession:
    Q9ULJ3
    Secondary Accessions:
    • Q5R2W1
    • Q5R2W2
    • Q6P4R0

    Protein attributes for ZBTB21 Gene

    Size:
    1066 amino acids
    Molecular mass:
    118870 Da
    Quaternary structure:
    • Homodimer. Interacts with ZBTB14.
    SequenceCaution:
    • Sequence=BAA86541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB21 Gene

    Alternative splice isoforms for ZBTB21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB21 Gene

Proteomics data for ZBTB21 Gene at MOPED

Post-translational modifications for ZBTB21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB21 Gene

Domains for ZBTB21 Gene

Gene Families for ZBTB21 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for ZBTB21 Gene

UniProtKB/Swiss-Prot:

ZBT21_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q9ULJ3
Similarity:
  • Contains 8 C2H2-type zinc fingers.:
    • Q9ULJ3
genes like me logo Genes that share domains with ZBTB21: view

Function for ZBTB21 Gene

Molecular function for ZBTB21 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcription repressor.

Gene Ontology (GO) - Molecular Function for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15629158
GO:0008327 methyl-CpG binding IDA 21029866
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB21: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB21 Gene

Localization for ZBTB21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB21 Gene

Nucleus. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells.

Gene Ontology (GO) - Cellular Components for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB21: view

Pathways for ZBTB21 Gene

SuperPathways for ZBTB21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 15629158
genes like me logo Genes that share ontologies with ZBTB21: view

No data available for Pathways by source for ZBTB21 Gene

Transcripts for ZBTB21 Gene

Unigene Clusters for ZBTB21 Gene

Zinc finger and BTB domain containing 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB21 Gene

No ASD Table

Relevant External Links for ZBTB21 Gene

GeneLoc Exon Structure for
ZBTB21
ECgene alternative splicing isoforms for
ZBTB21

Expression for ZBTB21 Gene

mRNA expression in normal human tissues for ZBTB21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB21 Gene

SOURCE GeneReport for Unigene cluster for ZBTB21 Gene Hs.434947

mRNA Expression by UniProt/SwissProt for ZBTB21 Gene

Q9ULJ3-ZBT21_HUMAN
Tissue specificity: Ubiquitous in fetal and adult tissues.
genes like me logo Genes that share expressions with ZBTB21: view

Orthologs for ZBTB21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB21 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF295 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB21 36
  • 81.9 (n)
  • 86.47 (a)
mouse
(Mus musculus)
Mammalia Zbtb21 36
  • 83.04 (n)
  • 86.83 (a)
Zbtb21 16
Zbtb21 37
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB21 37
  • 81 (a)
OneToOne
ZNF295 36
  • 76.59 (n)
  • 81.52 (a)
lizard
(Anolis carolinensis)
Reptilia ZBTB21 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20411 36
zbtb21 36
  • 64.02 (n)
  • 62.65 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb21 36
  • 58.94 (n)
  • 56.97 (a)
zbtb21 37
  • 55 (a)
OneToOne
Species with no ortholog for ZBTB21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB21 Gene

ENSEMBL:
Gene Tree for ZBTB21 (if available)
TreeFam:
Gene Tree for ZBTB21 (if available)

Paralogs for ZBTB21 Gene

Paralogs for ZBTB21 Gene

genes like me logo Genes that share paralogs with ZBTB21: view

Variants for ZBTB21 Gene

Sequence variations from dbSNP and Humsavar for ZBTB21 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs390853 -- 41,986,468(+) TAGAT(A/T)ATCAA downstream-variant-500B
rs397663 -- 41,986,548(+) ATTTA(C/G)CCCCC downstream-variant-500B
rs423235 -- 41,994,887(+) ttctc(A/G)tgata intron-variant
rs467244 -- 41,998,212(+) ttcta(A/C/G)acagg intron-variant
rs467618 -- 41,998,470(+) acagg(C/T)gtgag intron-variant

Relevant External Links for ZBTB21 Gene

HapMap Linkage Disequilibrium report
ZBTB21

No data available for Structural Variations from Database of Genomic Variants (DGV) for ZBTB21 Gene

Disorders for ZBTB21 Gene

No disorders were found for ZBTB21 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB21 Gene

Publications for ZBTB21 Gene

  1. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. (PMID: 15629158) Wang J. … Shimizu N. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for ZBTB21 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZBTB21
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB21
    • Block miRNA regulation of ZBTB21 using miScript Target Protectors
    • antibodies-online peptides for ZBTB21
    • antibodies-online antibodies for ZBTB21
    • antibodies-online kits for ZBTB21

    Sources for ZBTB21 Gene

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