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Aliases for ZBTB21 Gene

Aliases for ZBTB21 Gene

  • Zinc Finger And BTB Domain Containing 21 2 3
  • Zinc Finger Protein 295 2 3 4
  • ZNF295 3 4
  • Zinc Finger And BTB Domain-Containing Protein 21 3
  • KIAA1227 4

External Ids for ZBTB21 Gene

Previous HGNC Symbols for ZBTB21 Gene

  • ZNF295

Previous GeneCards Identifiers for ZBTB21 Gene

  • GC21M043409

Summaries for ZBTB21 Gene

GeneCards Summary for ZBTB21 Gene

ZBTB21 (Zinc Finger And BTB Domain Containing 21) is a Protein Coding gene. GO annotations related to this gene include methyl-CpG binding. An important paralog of this gene is ZBTB7B.

UniProtKB/Swiss-Prot for ZBTB21 Gene

  • Acts as a transcription repressor.

Gene Wiki entry for ZBTB21 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB21 Gene

Genomics for ZBTB21 Gene

Genomic Location for ZBTB21 Gene

41,986,831 bp from pter
42,010,387 bp from pter
23,557 bases
Minus strand

Genomic View for ZBTB21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB21 Gene

No data available for Regulatory Elements for ZBTB21 Gene

Proteins for ZBTB21 Gene

  • Protein details for ZBTB21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 21
    Protein Accession:
    Secondary Accessions:
    • Q5R2W1
    • Q5R2W2
    • Q6P4R0

    Protein attributes for ZBTB21 Gene

    1066 amino acids
    Molecular mass:
    118870 Da
    Quaternary structure:
    • Homodimer. Interacts with ZBTB14.
    • Sequence=BAA86541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBTB21 Gene

    Alternative splice isoforms for ZBTB21 Gene


neXtProt entry for ZBTB21 Gene

Proteomics data for ZBTB21 Gene at MOPED

Post-translational modifications for ZBTB21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBTB21 Gene

Domains for ZBTB21 Gene

Gene Families for ZBTB21 Gene

  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZBTB21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9ULJ3
  • Contains 1 BTB (POZ) domain.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB21: view

No data available for Suggested Antigen Peptide Sequences for ZBTB21 Gene

Function for ZBTB21 Gene

Molecular function for ZBTB21 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcription repressor.

Gene Ontology (GO) - Molecular Function for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15629158
GO:0008327 methyl-CpG binding IDA 21029866
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB21: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB21 Gene

Localization for ZBTB21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB21 Gene

Nucleus. Note=Colocalizes with ZBTB14 in nucleus in HEK293 cells.

Gene Ontology (GO) - Cellular Components for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB21: view

No data available for Subcellular locations from COMPARTMENTS for ZBTB21 Gene

Pathways for ZBTB21 Gene

SuperPathways for ZBTB21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 15629158
genes like me logo Genes that share ontologies with ZBTB21: view

No data available for Pathways by source for ZBTB21 Gene

Transcripts for ZBTB21 Gene

Unigene Clusters for ZBTB21 Gene

Zinc finger and BTB domain containing 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB21 Gene

No ASD Table

Relevant External Links for ZBTB21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB21 Gene

mRNA expression in normal human tissues for ZBTB21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB21 Gene

SOURCE GeneReport for Unigene cluster for ZBTB21 Gene Hs.434947

mRNA Expression by UniProt/SwissProt for ZBTB21 Gene

Tissue specificity: Ubiquitous in fetal and adult tissues.
genes like me logo Genes that share expressions with ZBTB21: view

No data available for mRNA differential expression in normal tissues for ZBTB21 Gene

Orthologs for ZBTB21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB21 36
  • 100 (a)
(Bos Taurus)
Mammalia ZNF295 36
  • 74 (a)
(Canis familiaris)
Mammalia ZBTB21 35
  • 81.9 (n)
  • 86.47 (a)
(Mus musculus)
Mammalia Zbtb21 35
  • 83.04 (n)
  • 86.83 (a)
Zbtb21 16
Zbtb21 36
  • 84 (a)
(Gallus gallus)
Aves ZBTB21 36
  • 81 (a)
ZNF295 35
  • 76.59 (n)
  • 81.52 (a)
(Anolis carolinensis)
Reptilia ZBTB21 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20411 35
zbtb21 35
  • 64.02 (n)
  • 62.65 (a)
(Danio rerio)
Actinopterygii zbtb21 35
  • 58.94 (n)
  • 56.97 (a)
zbtb21 36
  • 55 (a)
Species with no ortholog for ZBTB21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB21 Gene

Gene Tree for ZBTB21 (if available)
Gene Tree for ZBTB21 (if available)

Paralogs for ZBTB21 Gene

Paralogs for ZBTB21 Gene

genes like me logo Genes that share paralogs with ZBTB21: view

Variants for ZBTB21 Gene

Sequence variations from dbSNP and Humsavar for ZBTB21 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs390853 -- 41,986,468(+) TAGAT(A/T)ATCAA downstream-variant-500B
rs397663 -- 41,986,548(+) ATTTA(C/G)CCCCC downstream-variant-500B
rs423235 -- 41,994,887(+) ttctc(A/G)tgata intron-variant
rs467244 -- 41,998,212(+) ttcta(A/C/G)acagg intron-variant
rs467618 -- 41,998,470(+) acagg(C/T)gtgag intron-variant

Relevant External Links for ZBTB21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB21 Gene

Disorders for ZBTB21 Gene

No disorders were found for ZBTB21 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB21 Gene

Publications for ZBTB21 Gene

  1. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. (PMID: 15629158) Wang J. … Shimizu N. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for ZBTB21 Gene

  • antibodies-online peptides for ZBTB21
  • antibodies-online antibodies for ZBTB21
  • antibodies-online kits for ZBTB21

Sources for ZBTB21 Gene

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