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ZBTB20 Gene

protein-coding   GIFtS: 53

GC03M115540
zinc finger and BTB domain containing 20
(Previous name: zinc finger protein 288 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF288)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
A930017C21Rik 2
DKFZp566F123 1, 2
DPZF 1, 2, 3, 5
HOF 2
ODA-8S 1, 2
ZNF288 2, 3, 5
Descriptions
Dendritic-derived BTB/POZ zinc finger protein 3
Zinc finger protein 288 1, 2, 3
ortholog of mouse BTB (broad complex tramtrack
bric-brac)/POZ (px-virus and zinc finger) domain zinc
finger factor HOF 2
ortholog of mouse zinc finger protein 288 2
zinc finger 288 2
zinc finger and BTB domain containing 20 2
External Ids
HGNC: 135031
Entrez Gene: 261372
UniProtKB: Q9HC783
Ensembl: ENSG000001817227
Search outside databases for aliases for ZBTB20 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT20_HUMAN, Q9HC78
Function: May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and
immune responses

Gene Wiki entry for ZBTB20

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB20 gene  

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.31   HGNC cytogenetic band: 3q13.2

ZBTB20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M115540:     (about GC identifiers)

Start:
115,540,207 bp from pter
End:
116,348,817 bp from pter
Size:
808,611 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT20_HUMAN, Q9HC78 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 20  
Size: 741 amino acids; 81083 Da
Subunit: Can homodimerize. Binds to DNA
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q63HP6 Q8N6R5 Q9Y410
Alternative splicing: 2 isoforms:  Q9HC78-1   Q9HC78-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_056457.2  

    ENSEMBL proteins: 
    ENSP00000349803 ENSP00000377375 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZBTB20)
    Human Recombinant Proteins from Abnova (ZBTB20)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB20: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB20
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZBTB20), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZBTB20

    Assays for ZBTB20: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB20 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9HC78

    ProtoNet protein and cluster: Q9HC78

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT20_HUMAN, Q9HC78
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB20)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB20)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015642

                  Applied Biosystems Silencer® siRNAs for ZBTB20

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB20  
                         Sigma-Aldrich shRNA for ZBTB20  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015642
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015642
                                     untagged cDNA clone in CMV expression vector: NM_015642 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015642

    UniProtKB/Swiss-Prot: ZBT20_HUMAN, Q9HC78
    Function: May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and
    immune responses

    1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zbtb20):

    liver/biliary system

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for ZBTB20 (ENSP000003498033) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCN1ENSP000003608463STRING (score=.708)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB20

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB20)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB20)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015642

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB20  
                         Sigma-Aldrich shRNA for ZBTB20  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015642  

    REFSEQ mRNAs for ZBTB20 gene: 

    NM_015642.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015642  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015642
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015642
                                     untagged cDNA clone in CMV expression vector: NM_015642 

    Additional cDNA sequence: 

    AF139460.2 AK129968.1 AK225788.1 AK290116.1 AK315307.1 AL050276.1 BC010934.1 BC015587.2 
    BC029041.1 BC090936.1 BX647778.1 BX648237.1 XM_001722408.1 

    24/29 DOTS entries (see all 29 ):

    DT.95240212  DT.40246725  DT.100020366  DT.92387783  DT.444108  DT.101977362  DT.91861285  DT.120896865 
    DT.120896845  DT.120896958  DT.91713178  DT.97800011  DT.120896883  DT.120896895  DT.306601  DT.40126187 
    DT.436503  DT.75154358  DT.92017331  DT.95106915  DT.101985698  DT.102843415  DT.120896773  DT.120896789 

    24/94 AceView cDNA sequences (see all 94 ):

    BF512251 AK129968 BM931777 BC015587 AI828036 BI761113 AW293260 AA086317 
    T12777 N26227 BC029041 AI686533 NM_015642 AA099758 BF726061 AL050276 
    BX952347 BX088818 AI879752 BX118713 AI201460 AI445139 AA359918 BG708766 

    highest scoring ESTs for ZBTB20:

    AL050276 BC010934 BX647778 AA083981 AA359918 AA365840 AA828063 AA834935 AF139460 AI240155 

    Unigene Cluster for ZBTB20:

    Zinc finger and BTB domain containing 20
    Hs.655108  [show with all ESTs]
    Unigene Representative Sequence: BX648237


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000357258  ENST00000393785  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB20 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB20

    1 / 2 / 3

    9 probe-sets matching ZBTB20 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    38211_at2, 3 U95-A 1 1.00 1.00 0.11 0.43 AL050276 0.80 1.00 0.91 1

    80853_at2, 3 U95-E 1 1.00 1.00 0.89 1.18 AI821432 0.60 1.00 0.82 1

    76182_at2, 3 U95-E 1 0.94 1.00 0.85 0.83 AI760370 0.60 1.00 0.82 1

    205383_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_015642 0.60 1.00 0.82 1

    222357_at2, 3 U133-A 1 0.91 1.00 -- -- AW974823 0.20 1.00 0.72 1

    235308_at2, 3 U133-B 1 0.82 1.00 -- -- AW499525 0.40 1.00 0.76 1

    205383_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    222357_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --

    235308_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.655108

    Expression variation in blood from EXPOLDB for ZBTB20

    UniProtKB/Swiss-Prot: ZBT20_HUMAN, Q9HC78
    Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal
    liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB20 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB201   -- zinc finger and BTB domain containing 20 95.16(n)
    98.95(a)
    487987  XM_843445.1  XP_848538.1 
    chimpanzee
    (Pan troglodytes)
    ZBTB201   -- zinc finger and BTB domain containing 20 99.75(n)
    99.85(a)
    470888  XM_001160270.1  XP_001160270.1 
    cow
    (Bos taurus)
    ZBTB201   -- zinc finger and BTB domain containing 20 94.16(n)
    98.35(a)
    508864  XM_585702.3  XP_585702.3 
    rat
    (Rattus norvegicus)
    Zbtb201   -- zinc finger and BTB domain containing 20 92.07(n)
    97.31(a)
    288105  XM_213621.4  XP_213621.3 
    mouse
    (Mus musculus)
    Zbtb201, 5 16 (28.90 cM)5
    zinc finger and BTB domain containing 201, 5 92.17(n)1
    97.6(a)1
    564901  NM_019778.11  NP_062752.11 
     AA4098565  AA6453795  (see all 31)
    About this table        Species with no ortholog for ZBTB20

    ENSEMBL Gene Tree for ZBTB20
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB20 gene
    NACC12  ZBTB452  NACC22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/437 NCBI SNPs in ZBTB20 are shown (see all 437 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1026)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs27334231,2
    A,C,F,H,O115580338(-) CTTCAA/GTGTAA 1 -- int116Minor allele frequency- N:0.00EA NA EU WA 1474
    rs8702481,2
    A,C,F,H,O115577011(-) TGTATT/CCAAAC 1 -- int117Minor allele frequency- C:0.07NA EA EU WA 1258
    rs13570161,2
    A,C,F,H,O115549000(-) TTAGTA/TTAAAA 1 -- int112Minor allele frequency- T:0.23NA EA MN EU WA 1216
    rs20304391,2
    A,C,F,H,O115568675(-) TCACCG/ATAGCT 1 -- int113Minor allele frequency- A:0.23MN EU EA WA NA 2588
    rs27220051,2
    A,C,F,H,O115580250(-) AAAATA/TGCCCG 1 -- int111Minor allele frequency- T:0.37NA EU EA WA 980
    rs27220041,2
    A,C,F,H,O115569803(+) GTTCAT/CGTTAA 1 -- int111Minor allele frequency- C:0.32EU EA WA NA 972
    rs27220151,2
    A,C,F,H,O115550208(-) AAGATG/AAACTT 1 -- int18Minor allele frequency- A:0.19EU EA WA NA 1486
    rs27220061,2
    A,C,F,H,O115580195(-) TACCCA/GGCTTT 1 -- int116Minor allele frequency- G:0.37EA NA EU WA 1416
    rs26580551,2
    A,C,F,H116288321(-) CCATCA/GCATCA 1 -- int14Minor allele frequency- G:0.39EU EA WA 418
    rs67826561,2
    A,C,F,H116326200(+) cagaaA/Gacaga 1 -- int14Minor allele frequency- G:0.18EU EA WA 418
    About this table

    HapMap Linkage Disequilibrium images for ZBTB20 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606025

    Human Genome Epidemiology Navigator: ZBTB20 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/12 PubMed articles for ZBTB20 gene (see all 12 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 26137 HGNC: 13503 AceView: ZBTB20 Ensembl:ENSG00000181722 euGenes: HUgn26137
    ECgene: ZBTB20 H-InvDB: ZBTB20
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ZBTB20 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB20:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB20-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB20 Antibodies for ZBTB20
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZBTB20 Browse small molecules at Sigma-Aldrich
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