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Aliases for ZBTB20 Gene

Aliases for ZBTB20 Gene

  • Zinc Finger And BTB Domain Containing 20 2 3
  • Zinc Finger Protein 288 2 3 4
  • ZNF288 3 4 6
  • DPZF 3 4 6
  • Zinc Finger And BTB Domain-Containing Protein 20 3
  • Dendritic-Derived BTB/POZ Zinc Finger Protein 4
  • Dendritic Cell-Derived BTB/POZ Zinc Finger 3
  • BTB/POZ Zinc Finger Protein DPZF 3
  • ODA-8S 3
  • PRIMS 3
  • HOF 3

External Ids for ZBTB20 Gene

Previous Symbols for ZBTB20 Gene

  • ZNF288

Summaries for ZBTB20 Gene

GeneCards Summary for ZBTB20 Gene

ZBTB20 (Zinc Finger And BTB Domain Containing 20) is a Protein Coding gene. Diseases associated with ZBTB20 include primrose syndrome and intellectual disability - cataracts - calcified pinnae - myopathy. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription. An important paralog of this gene is NACC2.

UniProtKB/Swiss-Prot for ZBTB20 Gene

  • May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.

Gene Wiki entry for ZBTB20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB20 Gene

Genomics for ZBTB20 Gene

Genomic Location for ZBTB20 Gene

Start:
114,314,501 bp from pter
End:
115,147,280 bp from pter
Size:
832,780 bases
Orientation:
Minus strand

Genomic View for ZBTB20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB20 Gene

Regulatory Elements for ZBTB20 Gene

Proteins for ZBTB20 Gene

  • Protein details for ZBTB20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC78-ZBT20_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 20
    Protein Accession:
    Q9HC78
    Secondary Accessions:
    • Q63HP6
    • Q8N6R5
    • Q9Y410

    Protein attributes for ZBTB20 Gene

    Size:
    741 amino acids
    Molecular mass:
    81083 Da
    Quaternary structure:
    • Can homodimerize. Binds to DNA

    Alternative splice isoforms for ZBTB20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB20 Gene

Proteomics data for ZBTB20 Gene at MOPED

Post-translational modifications for ZBTB20 Gene

No data available for DME Specific Peptides for ZBTB20 Gene

Domains for ZBTB20 Gene

Gene Families for ZBTB20 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for ZBTB20 Gene

UniProtKB/Swiss-Prot:

ZBT20_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q9HC78
Similarity:
  • Contains 5 C2H2-type zinc fingers.:
    • Q9HC78
genes like me logo Genes that share domains with ZBTB20: view

Function for ZBTB20 Gene

Molecular function for ZBTB20 Gene

UniProtKB/Swiss-Prot Function: May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses.

Gene Ontology (GO) - Molecular Function for ZBTB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB20: view
genes like me logo Genes that share phenotypes with ZBTB20: view

Animal Models for ZBTB20 Gene

MGI Knock Outs for ZBTB20:

miRNA for ZBTB20 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZBTB20 Gene

Localization for ZBTB20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB20 Gene COMPARTMENTS Subcellular localization image for ZBTB20 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZBTB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB20: view

Pathways for ZBTB20 Gene

SuperPathways for ZBTB20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB20: view

No data available for Pathways by source for ZBTB20 Gene

Transcripts for ZBTB20 Gene

Unigene Clusters for ZBTB20 Gene

Zinc finger and BTB domain containing 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB20 Gene

No ASD Table

Relevant External Links for ZBTB20 Gene

GeneLoc Exon Structure for
ZBTB20
ECgene alternative splicing isoforms for
ZBTB20

Expression for ZBTB20 Gene

mRNA expression in normal human tissues for ZBTB20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBTB20 Gene

This gene is overexpressed in Testis (16.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB20 Gene

SOURCE GeneReport for Unigene cluster for ZBTB20 Gene Hs.655108

mRNA Expression by UniProt/SwissProt for ZBTB20 Gene

Q9HC78-ZBT20_HUMAN
Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocytes, and fetal liver.
genes like me logo Genes that share expressions with ZBTB20: view

Orthologs for ZBTB20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB20 36
  • 99.87 (n)
  • 100 (a)
ZBTB20 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB20 36
  • 94.6 (n)
  • 98.38 (a)
ZBTB20 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB20 36
  • 95.73 (n)
  • 99.19 (a)
ZBTB20 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb20 36
  • 92.85 (n)
  • 97.71 (a)
Zbtb20 16
Zbtb20 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB20 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb20 36
  • 92.17 (n)
  • 97.46 (a)
chicken
(Gallus gallus)
Aves ZBTB20 36
  • 83.11 (n)
  • 91.58 (a)
ZBTB20 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB20 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb20 36
  • 78.41 (n)
  • 84.1 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27779 36
zbtb20 36
  • 71.53 (n)
  • 72.06 (a)
zbtb20 37
  • 66 (a)
OneToOne
Species with no ortholog for ZBTB20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB20 Gene

ENSEMBL:
Gene Tree for ZBTB20 (if available)
TreeFam:
Gene Tree for ZBTB20 (if available)

Paralogs for ZBTB20 Gene

Pseudogenes.org Pseudogenes for ZBTB20 Gene

genes like me logo Genes that share paralogs with ZBTB20: view

Variants for ZBTB20 Gene

Sequence variations from dbSNP and Humsavar for ZBTB20 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs185457 -- 114,912,267(+) ctaaa(A/G)aaagc intron-variant
rs260174 -- 114,939,959(-) ACAAT(G/T)AAAAT intron-variant
rs260175 -- 114,942,209(-) TTTAC(A/G)TGATT intron-variant
rs260176 -- 114,945,209(+) TCAAA(A/C)TAAGA intron-variant
rs260177 -- 114,946,425(+) aaaat(C/T)ggggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB20 Gene

Variant ID Type Subtype PubMed ID
nsv829679 CNV Gain 17160897
esv2664589 CNV Deletion 23128226
dgv77n68 CNV Gain 17160897
nsv3952 CNV Insertion 18451855
esv998582 CNV Deletion 20482838
esv2671955 CNV Deletion 23128226
esv22752 CNV Loss 19812545
esv2535300 CNV Insertion 19546169
esv272930 CNV Insertion 20981092
esv267795 CNV Insertion 20981092
esv2438147 CNV Deletion 19546169
esv1006341 CNV Deletion 20482838
esv2097985 CNV Deletion 18987734
esv2725787 CNV Deletion 23290073
esv1002866 CNV Deletion 20482838
nsv237808 CNV Loss 16902084
esv2572379 CNV Deletion 19546169
esv8517 CNV Loss 19470904
esv1548513 CNV Deletion 17803354
esv267895 CNV Insertion 20981092
esv2577063 CNV Deletion 19546169
nsv521467 CNV Loss 19592680
dgv5233n71 CNV Loss 21882294
esv2725788 CNV Deletion 23290073
nsv3953 CNV Loss 18451855
nsv10308 CNV Loss 18304495
esv2599243 CNV Deletion 19546169
dgv881e199 CNV Deletion 23128226
esv2505508 CNV Loss 19546169
nsv436390 CNV Deletion 17901297
esv2725789 CNV Deletion 23290073
nsv499011 CNV Loss 21111241
esv21675 CNV Loss 19812545
nsv514164 CNV Loss 21397061
nsv437878 CNV Loss 16468122
esv2421899 CNV Deletion 20811451
nsv442871 CNV CNV 18776908
nsv433365 CNV Loss 18776910
nsv437337 CNV Loss 16327808
nsv829683 CNV Gain 17160897
esv2656651 CNV Deletion 23128226
esv29079 CNV Loss 19812545

Relevant External Links for ZBTB20 Gene

HapMap Linkage Disequilibrium report
ZBTB20
Human Gene Mutation Database (HGMD)
ZBTB20

Disorders for ZBTB20 Gene

UniProtKB/Swiss-Prot

ZBT20_HUMAN
  • Primrose syndrome (PRIMS) [MIM:259050]: A disease characterized by macrocephaly, intellectual disability, disturbed behavior, dysmorphic facial features, ectopic calcifications, large calcified ear auricles, and progressive muscle wasting. {ECO:0000269 PubMed:25017102}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ZBTB20 Gene

Relevant External Links for ZBTB20

Genetic Association Database (GAD)
ZBTB20
Human Genome Epidemiology (HuGE) Navigator
ZBTB20
genes like me logo Genes that share disorders with ZBTB20: view

Publications for ZBTB20 Gene

  1. Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6. (PMID: 11352661) Zhang W. … Cao X. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  2. Assignment of the human zinc finger gene, ZNF288, to chromosome 3 band q13.2 by radiation hybrid mapping and fluorescence in situ hybridisation. (PMID: 10965110) Harboe T.L. … Tommerup N. (Cytogenet. Cell Genet. 2000) 2 3
  3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M. … Iwata N. (Biol. Psychiatry 2010) 3 49
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for ZBTB20 Gene

Sources for ZBTB20 Gene

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