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Aliases for ZBTB2 Gene

Aliases for ZBTB2 Gene

  • Zinc Finger And BTB Domain Containing 2 2 3 5
  • ZNF437 3 4
  • KIAA1483 4

External Ids for ZBTB2 Gene

Previous GeneCards Identifiers for ZBTB2 Gene

  • GC06M151640
  • GC06M151716
  • GC06M151777
  • GC06M151726
  • GC06M151685
  • GC06M149247

Summaries for ZBTB2 Gene

GeneCards Summary for ZBTB2 Gene

ZBTB2 (Zinc Finger And BTB Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB2 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB2 Gene

Genomics for ZBTB2 Gene

Regulatory Elements for ZBTB2 Gene

Promoters for ZBTB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB2 Gene

151,364,115 bp from pter
151,391,700 bp from pter
27,586 bases
Minus strand

Genomic View for ZBTB2 Gene

Genes around ZBTB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB2 Gene

Proteins for ZBTB2 Gene

  • Protein details for ZBTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K7C7
    • Q5SZ81
    • Q9P245

    Protein attributes for ZBTB2 Gene

    514 amino acids
    Molecular mass:
    57337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB2 Gene

Proteomics data for ZBTB2 Gene at MOPED

Post-translational modifications for ZBTB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZBTB2 Gene

Domains & Families for ZBTB2 Gene

Gene Families for ZBTB2 Gene

Protein Domains for ZBTB2 Gene

Suggested Antigen Peptide Sequences for ZBTB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 4 C2H2-type zinc fingers.
  • Contains 1 BTB (POZ) domain.
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB2: view

Function for ZBTB2 Gene

Molecular function for ZBTB2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZBTB2: view

Animal Model Products

miRNA for ZBTB2 Gene

miRTarBase miRNAs that target ZBTB2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB2 Gene

Localization for ZBTB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB2 Gene

Subcellular locations from

Jensen Localization Image for ZBTB2 Gene COMPARTMENTS Subcellular localization image for ZBTB2 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ZBTB2 Gene

Pathways & Interactions for ZBTB2 Gene

SuperPathways for ZBTB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZBTB2 Gene

Drugs & Compounds for ZBTB2 Gene

No Compound Related Data Available

Transcripts for ZBTB2 Gene

mRNA/cDNA for ZBTB2 Gene

Unigene Clusters for ZBTB2 Gene

Zinc finger and BTB domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB2 Gene

No ASD Table

Relevant External Links for ZBTB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB2 Gene

mRNA expression in normal human tissues for ZBTB2 Gene

Protein differential expression in normal tissues from HIPED for ZBTB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.6), CD4 Tcells (11.2), and CD8 Tcells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB2 Gene

SOURCE GeneReport for Unigene cluster for ZBTB2 Gene Hs.520073

genes like me logo Genes that share expression patterns with ZBTB2: view

Protein tissue co-expression partners for ZBTB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB2 Gene

Orthologs for ZBTB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB2 35
  • 99.42 (n)
  • 99.61 (a)
ZBTB2 36
  • 100 (a)
(Bos Taurus)
Mammalia ZBTB2 36
  • 96 (a)
ZBTB2 35
  • 87.48 (n)
  • 96.5 (a)
(Canis familiaris)
Mammalia ZBTB2 35
  • 89.3 (n)
  • 97.28 (a)
ZBTB2 36
  • 72 (a)
(Mus musculus)
Mammalia Zbtb2 36
  • 95 (a)
Zbtb2 16
Zbtb2 35
  • 85.67 (n)
  • 94.94 (a)
(Monodelphis domestica)
Mammalia ZBTB2 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Zbtb2 35
  • 85.67 (n)
  • 94.75 (a)
(Gallus gallus)
Aves ZBTB2 36
  • 89 (a)
ZBTB2 35
  • 82.91 (n)
  • 89.43 (a)
(Anolis carolinensis)
Reptilia ZBTB2 36
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1343 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10189 35
zbtb2 35
  • 73.45 (n)
  • 79.06 (a)
(Danio rerio)
Actinopterygii zbtb2a 36
  • 51 (a)
zbtb2b 36
  • 48 (a)
wufc05d08 35
zbtb2b 35
  • 62.58 (n)
  • 60.86 (a)
Species with no ortholog for ZBTB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB2 Gene

Gene Tree for ZBTB2 (if available)
Gene Tree for ZBTB2 (if available)

Paralogs for ZBTB2 Gene

(2) SIMAP similar genes for ZBTB2 Gene using alignment to 1 proteins: Pseudogenes for ZBTB2 Gene

genes like me logo Genes that share paralogs with ZBTB2: view

Variants for ZBTB2 Gene

Sequence variations from dbSNP and Humsavar for ZBTB2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1061987 -- 151,365,017(-) TTACT(A/T)CAGAA utr-variant-3-prime
rs3900024 -- 151,385,435(+) CTTTT(A/G)GAAGT intron-variant
rs3832449 -- 151,364,394(-) TTTTT(-/T)CTTTC utr-variant-3-prime
rs3849797 -- 151,385,528(+) CAAAA(C/T)AGCTT intron-variant
rs3849798 -- 151,385,753(+) CTTAC(C/T)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB2 Gene

Variant ID Type Subtype PubMed ID
nsv5541 CNV Insertion 18451855

Variation tolerance for ZBTB2 Gene

Residual Variation Intolerance Score: 9.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB2 Gene

Disorders for ZBTB2 Gene

Relevant External Links for ZBTB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZBTB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB2 Gene

Publications for ZBTB2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65. (PMID: 25609694) Kim M.Y. … Hur M.W. (Nucleic Acids Res. 2015) 3
  4. DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation. (PMID: 24607898) Lafaye C. … Breton J. (Biochem. Biophys. Res. Commun. 2014) 3
  5. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H. … D'Andrea A.D. (Mol. Cell 2014) 3

Products for ZBTB2 Gene

Sources for ZBTB2 Gene

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