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Aliases for ZBTB2 Gene

Aliases for ZBTB2 Gene

  • Zinc Finger And BTB Domain Containing 2 2 3 5
  • ZNF437 3 4
  • Zinc Finger And BTB Domain-Containing Protein 2 3
  • KIAA1483 4

External Ids for ZBTB2 Gene

Previous GeneCards Identifiers for ZBTB2 Gene

  • GC06M151640
  • GC06M151716
  • GC06M151777
  • GC06M151726
  • GC06M151685
  • GC06M149247

Summaries for ZBTB2 Gene

GeneCards Summary for ZBTB2 Gene

ZBTB2 (Zinc Finger And BTB Domain Containing 2) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. An important paralog of this gene is ZBTB25.

UniProtKB/Swiss-Prot for ZBTB2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB2 Gene

Genomics for ZBTB2 Gene

Regulatory Elements for ZBTB2 Gene

Enhancers for ZBTB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H151323 1.3 ENCODE dbSUPER 21.1 +65.9 65935 4.4 FOXA2 ARID4B DMAP1 ZNF2 GTF3C2 GLIS2 ZNF143 RUNX3 SP3 ZHX2 ZBTB2 HSPA8P15 ENSG00000232290 AKAP12 RMND1 RN7SKP268 GC06P151355 PIR45449
GH06H151696 0.8 dbSUPER 23 -305.5 -305524 1.5 ZFP64 ZNF140 ZNF266 ZNF697 ZNF664 ZNF791 ZNF138 ZNF547 ZNF433 ZNF202 HSPA8P15 ZBTB2 SYNE1 AKAP12 GC06P151669 GC06P151812
GH06H150812 1.5 Ensembl ENCODE dbSUPER 11.9 +577.6 577586 3.5 HDGF PKNOX1 ATF1 FOXA2 FEZF1 GLI4 ZNF143 FOS ATF7 ZNF202 HSPA8P15 ZBTB2 ENSG00000231760 PDCL3P5 ENSG00000226599
GH06H151451 1.2 ENCODE 14.1 -60.7 -60721 2.6 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN RMND1 HSPA8P15 ZBTB2 ARMT1 CCDC170
GH06H150854 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +534.7 534651 4.9 GTF2F1 TBP JUN MAX ZNF7 RFX5 ZFHX2 POLR2A ZNF366 ZNF350 ZBTB2 MTHFD1L PDCL3P5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB2 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ZBTB2 Gene

Genomic Locations for ZBTB2 Gene
27,586 bases
Minus strand

Genomic View for ZBTB2 Gene

Genes around ZBTB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB2 Gene

Proteins for ZBTB2 Gene

  • Protein details for ZBTB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger and BTB domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K7C7
    • Q5SZ81
    • Q9P245

    Protein attributes for ZBTB2 Gene

    514 amino acids
    Molecular mass:
    57337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB2 Gene

Post-translational modifications for ZBTB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB2 Gene

No data available for DME Specific Peptides for ZBTB2 Gene

Domains & Families for ZBTB2 Gene

Gene Families for ZBTB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB2 Gene

Suggested Antigen Peptide Sequences for ZBTB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB2: view

No data available for UniProtKB/Swiss-Prot for ZBTB2 Gene

Function for ZBTB2 Gene

Molecular function for ZBTB2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB2 Gene

Gene Ontology (GO) - Molecular Function for ZBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 25609694
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IC --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25609694
genes like me logo Genes that share ontologies with ZBTB2: view
genes like me logo Genes that share phenotypes with ZBTB2: view

Animal Model Products

miRNA for ZBTB2 Gene

miRTarBase miRNAs that target ZBTB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB2 Gene

Localization for ZBTB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB2 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB2: view

Pathways & Interactions for ZBTB2 Gene

SuperPathways for ZBTB2 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with ZBTB2: view

Pathways by source for ZBTB2 Gene

1 BioSystems pathway for ZBTB2 Gene

Gene Ontology (GO) - Biological Process for ZBTB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 19380588
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB2: view

No data available for SIGNOR curated interactions for ZBTB2 Gene

Drugs & Compounds for ZBTB2 Gene

No Compound Related Data Available

Transcripts for ZBTB2 Gene

mRNA/cDNA for ZBTB2 Gene

Unigene Clusters for ZBTB2 Gene

Zinc finger and BTB domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB2 Gene

No ASD Table

Relevant External Links for ZBTB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBTB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB2 Gene

Protein differential expression in normal tissues from HIPED for ZBTB2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.6), CD4 Tcells (11.2), and CD8 Tcells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBTB2 Gene

Protein tissue co-expression partners for ZBTB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB2 Gene:


SOURCE GeneReport for Unigene cluster for ZBTB2 Gene:


Evidence on tissue expression from TISSUES for ZBTB2 Gene

  • Liver(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZBTB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB2 Gene

Orthologs for ZBTB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZBTB2 33 34
  • 99.42 (n)
(Monodelphis domestica)
Mammalia ZBTB2 34
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia ZBTB2 34
  • 92 (a)
(Canis familiaris)
Mammalia ZBTB2 33 34
  • 89.3 (n)
(Bos Taurus)
Mammalia ZBTB2 33 34
  • 87.48 (n)
(Mus musculus)
Mammalia Zbtb2 33 16 34
  • 85.67 (n)
(Rattus norvegicus)
Mammalia Zbtb2 33
  • 85.67 (n)
(Gallus gallus)
Aves ZBTB2 33 34
  • 82.91 (n)
(Anolis carolinensis)
Reptilia ZBTB2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb2 33
  • 73.45 (n)
Str.10189 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1343 33
(Danio rerio)
Actinopterygii zbtb2b 33 34
  • 62.58 (n)
zbtb2a 34
  • 51 (a)
wufc05d08 33
Species where no ortholog for ZBTB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB2 Gene

Gene Tree for ZBTB2 (if available)
Gene Tree for ZBTB2 (if available)

Paralogs for ZBTB2 Gene

Paralogs for ZBTB2 Gene

(2) SIMAP similar genes for ZBTB2 Gene using alignment to 1 proteins: Pseudogenes for ZBTB2 Gene

genes like me logo Genes that share paralogs with ZBTB2: view

Variants for ZBTB2 Gene

Sequence variations from dbSNP and Humsavar for ZBTB2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000025207 -- 151,389,981(+) CGACG(C/T)CGGCC intron-variant, upstream-variant-2KB
rs1000099038 -- 151,384,324(+) AAGAT(C/G)TCTAC intron-variant
rs1000120347 -- 151,390,926(+) CCGGC(C/T)GCCGC intron-variant, utr-variant-5-prime
rs1000165155 -- 151,382,807(+) CGCTC(A/G)GCCTC intron-variant
rs1000193493 -- 151,375,061(+) CTTGC(A/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB2 Gene

Variant ID Type Subtype PubMed ID
nsv5541 CNV insertion 18451855
nsv1074433 CNV deletion 25765185

Variation tolerance for ZBTB2 Gene

Residual Variation Intolerance Score: 9.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB2 Gene

Disorders for ZBTB2 Gene

Relevant External Links for ZBTB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZBTB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB2 Gene

Publications for ZBTB2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ZBTB2 Gene

Sources for ZBTB2 Gene

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