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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZBTB2 Gene

protein-coding GIFtS: 48
GCID: GC06M151685

zinc finger and BTB domain containing 2

Explore 3 diseases affiliated with
ZBTB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 2¹ ²
ZNF437¹ ² ³
KIAA1483¹ ³
BA351K16.2¹
Zinc Finger And BTB Domain-Containing Protein 2²

External Ids:	HGNC: 20868¹	Entrez Gene: 57621²	Ensembl: ENSG00000181472⁷	UniProtKB: Q8N680³

Export aliases for ZBTB2 gene to outside databases

Previous GC identifers: GC06M151640 GC06M151716 GC06M151777 GC06M151726 GC06M149247

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBTB2_HUMAN, Q8N680

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZBTB2 gene promoter:
Sox5 POU3F1 SRY POU2F1 HSF2 POU2F1b POU2F1a Sox9 POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZBTB2 promoter sequence

Search SABiosciences Chromatin IP Primers for ZBTB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q25.1

ZBTB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M151685: view genomic region (about GC identifiers)

Start:	151,685,250 bp from pter	End:	151,712,683 bp from pter
Size:	27,434 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZBTB2_HUMAN, Q8N680 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 2

Size: 514 amino acids; 57337 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: A8K7C7 Q5SZ81 Q9P245

Explore the universe of human proteins at neXtProt for ZBTB2: NX_Q8N680

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N680

ZBTB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065912.1

ENSEMBL proteins:

ENSP00000323183

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ZBTB2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZBTB2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR015880 Znf_C2H2-like

IPR011333 BTB/POZ_fold

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR013069 BTB_POZ

IPR000210 BTB/POZ-like

Graphical View of Domain Structure for InterPro Entry Q8N680

ProtoNet protein and cluster: Q8N680

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBTB2_HUMAN, Q8N680

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 4 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZBTB2_HUMAN, Q8N680

Function: May be involved in transcriptional regulation

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZBTB2 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for ZBTB2:

Decreased Wnt reporter activit	Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r	Decreased p24 protein expressi
Increased cell death HMECs cel	Increased gamma-H2AX phosphory	Metaphase cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZBTB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for ZBTB2 (Q8N680³ ENSP00000323183⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637³, ENSP00000269305⁴	I2D: score=1 STRING: ENSP00000269305
SUMO2	P61956³, ENSP00000405965⁴	I2D: score=1 STRING: ENSP00000405965
WDR48	Q8TAF3³, ENSP00000307491⁴	I2D: score=2 STRING: ENSP00000307491
STAT6	P42226³, ENSP00000300134⁴	I2D: score=1 STRING: ENSP00000300134
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=2 STRING: ENSP00000262367

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZBTB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for ZBTB2
Search CenterWatch for drugs/clinical trials and news about ZBTB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZBTB2 gene:

NM_020861.1

Unigene Cluster for ZBTB2:

Zinc finger and BTB domain containing 2

Hs.520073 [show with all ESTs]

Unigene Representative Sequence: BC020172

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000325144(uc003qoh.3)

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		hsa-miR-3163 hsa-miR-548am hsa-miR-146a hsa-miR-130a* hsa-miR-23c hsa-miR-1284 hsa-miR-153 hsa-miR-23b

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Additional cDNA sequence:

AB040916.1 AJ420526.1 AK092886.1 AK291942.1 AL832957.1 BC020172.1

5 DOTS entries:

DT.110934 DT.95163737 DT.100748291 DT.100736631 DT.100736632

24/68 AceView cDNA sequences (see all 68):

CB047004 AI689206 AW674826 BI818997 AA446591 BQ581278 AA994297 NM_020861

BC020172 BF665643 BU579889 BM681132 AX747790 AA446719 BM727705 AW243652

AK092886 AI423715 AL832957 BQ128123 BM828414 CB961287 AI370863 BG333741

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZBTB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAGTTGAG

About this image

ZBTB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZBTB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB2

SOURCE GeneReport for Unigene cluster: Hs.520073

SABiosciences Custom PCR Arrays for ZBTB2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB2 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ZBTB2¹	zinc finger and BTB domain containing 2	82.91(n) 89.43(a)		421635 NM_001031070.1 NP_001026241.1
lizard (Anolis carolinensis)	Reptilia	ZBTB2⁶	--	87(a)	1 ↔ 1	GL343259.1(1130076-1133649)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1343²	Xenopus laevis transcribed sequence with weak similarity more	77.22(n)		BJ043335.1
zebrafish (Danio rerio)	Actinopterygii	wufc05d08²	Danio rerio mRNA similar to KIAA1483 protein (cDNA more	76.85(n)		BC049490.1

ENSEMBL Gene Tree for ZBTB2 (if available)
TreeFam Gene Tree for ZBTB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZBTB2 gene

ZBTB25² ZBTB1²

2 SIMAP similar genes for ZBTB2 using alignment to 1 protein entry: ZBTB2_HUMAN:

DKFZp666M0210 ZBTB25

ZBTB2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZBTB2
PGOHUM00000244612

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182547783^1,2		--	151684772(+)	`ATAAGC/TATGGA`	1	--	int¹		0	--	--	--	--
rs12234164^1,2	H	--	151684841(+)	`GAAAAC/GGACTC`	1	--	int¹		4		NS EA	420
rs185526341^1,2		--	151684882(+)	`TCCCAC/GCACTT`	1	--	int¹		0	--	--	--	--
rs10571659^1,2	C	--	151685131(+)	`aaaaa-/AA AAAAAaaaaa`	1	--	int¹		1		NA	2
rs67315307^1,2	C,	--	151708484(+)	`CTCAG-/TGTCAACACT GAGAAGACATTTTGTCA`	1	--	int¹		0	--	--	--	--
rs57174991^1,2	C	--	151708493(+)	`AACAC-/TGAGAAGACA TTTTGTCAACACAGCGG`	1	--	int¹		1		NA	2
rs79296383^1,2	C,	--	151708493(+)	`AACACA/TGAGAA`	1	--	int¹		0	--	--	--	--
rs76392120^1,2	C	--	151708497(+)	`CTGAGA/GAGACA`	1	--	int¹		0	--	--	--	--
rs183726853^1,2		--	151708518(+)	`ACAGCA/GGAAAA`	1	--	int¹		0	--	--	--	--
rs5880929^1,2	C,	--	151711485(+)	`CCCCC-/GTCCCT`	1	--	int¹ trp³		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZBTB2 (151685250 - 151712683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB2: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZBTB2 for disorders About GeneDecksing

3 diseases for ZBTB2: About MalaCards

chronic myeloid leukemia myeloid leukemia leukemia

Human Genome Epidemiology (HuGE) Navigator: ZBTB2 (1 document)

Export disorders for ZBTB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZBTB2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with ZBTB2)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2, 3} Nagase T.... Ohara O. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)¹ Yatim A....Benkirane M. (2012)
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. (PubMed id 21540461)¹ Kim D.H....Lipton J.H. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)¹ Tatham M.H....Hay R.T. (2011)
An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)¹ Golebiowski F....Hay R.T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57621	HGNC: 20868	AceView: ZBTB2	Ensembl:ENSG00000181472	euGenes: HUgn57621
ECgene: ZBTB2	H-InvDB: ZBTB2

(According to HUGE)
About This Section

HUGE: KIAA1483

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZBTB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZBTB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZBTB2 gene:
Search GeneIP for patents involving ZBTB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for ZBTB2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB2
	OriGene Protein Over-expression Lysate for ZBTB2		Browse OriGene Fluorogenic Cell Assay Kits
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB2

	GenScript Custom Purified and Recombinant Proteins Services for ZBTB2		GenScript cDNA clones with any tag delivered in your preferred vector for ZBTB2
	GenScript Custom Assay Services for ZBTB2		GenScript Custom Superior Antibodies Services for ZBTB2
	GenScript Custom overexpressing Cell Line Services for ZBTB2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	SwitchGear 3'UTR luciferase reporter plasmids for ZBTB2
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ThermoFisher Antibodies for ZBTB2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZBTB2 gene at Home site.

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ZBTB2 Gene

zinc finger and BTB domain containing 2

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ZBTB2 Gene

zinc finger and BTB domain containing 2

Aliasesfor ZBTB2 gene

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Genomic Viewsfor ZBTB2 gene

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