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ZBTB18 Gene

protein-coding GIFtS: 42
GCID: GC01P244216

Zinc Finger And BTB Domain Containing 18

(Previous name: zinc finger protein 238)
(Previous symbol: ZNF238)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 18¹ ²		58 KDa Repressor Protein² ³
ZNF238¹ ² ³ ⁵		TAZ-1² ³
Zinc Finger Protein 238¹ ² ³		MRD22² ⁵
RP58² ³ ⁵		C2H2-171²
Transcriptional Repressor RP58² ³		Zinc Finger And BTB Domain-Containing Protein 18²
Translin-Associated Zinc Finger Protein 1² ³		TAZ1³
Zinc Finger Protein C2H2-171² ³

External Ids:	HGNC: 13030¹	Entrez Gene: 10472²	Ensembl: ENSG00000179456⁷	OMIM: 608433⁵	UniProtKB: Q99592³

Export aliases for ZBTB18 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZBTB18 Gene:

This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in

neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of

chromatin to target genes. Alternative splicing results in multiple transcript variants. (provided by RefSeq, May

2013)

GeneCards Summary for ZBTB18 Gene:

ZBTB18 (zinc finger and BTB domain containing 18) is a protein-coding gene. Diseases associated with ZBTB18 include mental retardation, autosomal dominant 22, and barth syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB10.

UniProtKB/Swiss-Prot: ZBT18_HUMAN, Q99592

Function: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and

brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2

inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating

the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence

5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein

complexes. May also play a role in the organization of chromosomes in the nucleus

Gene Wiki entry for ZBTB18 (ZNF238) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_167186.2 NC_018912.2

Regulatory elements:

Search for regulatory transcription factor binding sites for ZBTB18
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZBTB18 promoter sequence

Search Chromatin IP Primers for ZBTB18

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44

ZBTB18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB18 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P244216: view genomic region (about GC identifiers)

Start:	244,214,561 bp from pter	End:	244,220,778 bp from pter
Size:	6,218 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZBT18_HUMAN, Q99592 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 18

Size: 522 amino acids; 58354 Da

Subunit: Interacts with DNMT3A

Secondary accessions: A8K5U3 Q13397 Q5VU40 Q8N463 Q9UD99

Alternative splicing: 2 isoforms: Q99592-1 Q99592-2

Explore the universe of human proteins at neXtProt for ZBTB18: NX_Q99592

Explore proteomics data for ZBTB18 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See ZBTB18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001265125.1 NP_006343.2 NP_991331.1

ENSEMBL proteins:

ENSP00000351539

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

BTBD: BTB/POZ domain containing

ZNF: Zinc fingers, C2H2-type

Selected InterPro protein domains (see all 6):

IPR000210 BTB/POZ-like

IPR015880 Znf_C2H2-like

IPR011333 BTB/POZ_fold

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR013069 BTB_POZ

Graphical View of Domain Structure for InterPro Entry Q99592

ProtoNet protein and cluster: Q99592

2 Blocks protein domains:

IPB000210 BTB/POZ domain

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZBT18_HUMAN, Q99592

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 4 C2H2-type zinc fingers

ZBTB18 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ZBT18_HUMAN, Q99592

Function: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and

brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2

inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating

the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence

5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein

complexes. May also play a role in the organization of chromosomes in the nucleus

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	9013868
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	9756912
GO:0005515	protein binding	--	--
GO:0043565	sequence-specific DNA binding	IDA	9756912
GO:0046872	metal ion binding	IEA	--

ZBTB18 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Zbtb18):

cellular

growth/size/body

mortality/aging

nervous system

ZBTB18 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Zbtb18^tm1Haok for ZBTB18

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB18

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB18

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB18

Transcription Factor Targeting:

		Selected GeneGlobe predicted Target genes for ZBTB18 (see all 441):
		ABCD2, ABHD13, ABI2, ABTB2, ADCYAP1R1, AHCYL2, AHSA1, AIDA, AKAP11, AKR7A2

miRNA Products:		miRTarBase miRNAs that target ZBTB18: hsa-mir-106b-3p (MIRT038588), hsa-mir-548b-3p (MIRT016240), hsa-mir-590-3p (MIRT016212), hsa-mir-215-5p (MIRT024510), hsa-mir-128-3p (MIRT021920), hsa-mir-192-5p (MIRT026265), hsa-mir-26b-5p (MIRT029041), hsa-mir-338-3p (MIRT003042), hsa-mir-877-3p (MIRT036898)

		Block miRNA regulation of human, mouse, rat ZBTB18 using miScript Target Protectors
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB18

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ZBT18_HUMAN, Q99592: Nucleus. Note=Associates with condensed chromatin

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	TAS	9756912
GO:0005634	nucleus	TAS	9013868
GO:0005730	NOT nucleolus	IDA	--
GO:0015630	microtubule cytoskeleton	IDA	--
GO:0045171	intercellular bridge	IDA	--

ZBTB18 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ZBTB18
Interactions:

Search GeneGlobe Interaction Network for ZBTB18

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for ZBTB18 (Q99592³ ENSP00000351539⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAK1	Q13153³, ENSP00000278568⁴	I2D: score=3 STRING: ENSP00000278568
DNMT3A	Q9Y6K1³, ENSP00000264709⁴	I2D: score=2 STRING: ENSP00000264709
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
DNMT3B	Q9UBC3³, ENSP00000328547⁴	I2D: score=1 STRING: ENSP00000328547
KBTBD7	Q8WVZ9³	I2D: score=1

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Gene Ontology (GO): Selected biological process terms (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0001701	in utero embryonic development	IEA	--
GO:0006351	transcription, DNA-templated	IEA	--
GO:0007519	skeletal muscle tissue development	ISS	--
GO:0021549	cerebellum development	IEA	--

ZBTB18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ZBTB18 (ZBT18)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ZBTB18 gene (3 alternative transcripts):

NM_001278196.1 NM_006352.4 NM_205768.2

Unigene Cluster for ZBTB18:

Zinc finger and BTB domain containing 18

Hs.69997 [show with all ESTs]

Unigene Representative Sequence: BC078175

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000358704(uc001iad.4)

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		QuantiFast Probe-based Assays in human, mouse, rat ZBTB18

Additional mRNA sequence:

AJ001388.1 AK291408.1 AK293892.1 AK310634.1 AL050055.1 BC036677.2 BC078175.1 U38896.1

X95072.1

8 DOTS entries:

DT.100813582 DT.413626 DT.92425268 DT.95090455 DT.100813581 DT.92425274 DT.121505004 DT.75102535

Selected AceView cDNA sequences (see all 47):

AA331555 AA334942 T07956 BM475884 AA301315 T05975 BQ220621 NM_205768

T32155 BX440836 BX419577 CB216500 AA347500 BQ882698 AA349504 T30946

U38896 AA426106 BX420071 AW665310 T30905 BM562720 T32158 BC036677

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZBTB18 expression in normal human tissues (normalized intensities) ZBTB18 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

ZBTB18 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Brain (Nervous System) fully expand to see all 18 entries
Thalamus
cerebellum

Neural Tube (Nervous System)
Telencephalon

ZBTB18 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ZBTB18 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.69997

UniProtKB/Swiss-Prot: ZBT18_HUMAN, Q99592

Tissue specificity: Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower

level, other tissues

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZBTB18 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zbtb18^{1 , 5}	zinc finger protein 238⁵ zinc finger and BTB domain containing 18¹	95.86(n)¹ 99.44(a)¹		1 (82.72 cM)⁵ 30928¹ NM_001012330.1¹ NP_001012330.1¹ 177444661⁵
chicken (Gallus gallus)	Aves	ZNF238¹	zinc finger protein 238	91.9(n) 97.36(a)		428580 XM_426137.4 XP_426137.4
lizard (Anolis carolinensis)	Reptilia	ZBTB18⁶	zinc finger and BTB domain containing 18	97(a)	1 ↔ 1	GL343285.1(812863-814431)
African clawed frog (Xenopus laevis)	Amphibia	znf238-prov²	zinc finger protein 238	82.11(n)		BC048019.1
zebrafish (Danio rerio)	Actinopterygii	BI846629.1²	--	84.71(n)		BI846629.1

ENSEMBL Gene Tree for ZBTB18 (if available)
TreeFam Gene Tree for ZBTB18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ZBTB18 gene

ZBTB10² ZBTB3² ZBTB8A² ZBTB44² ZBTB5² ENSG00000254553² ZBTB49² HIC1²

ZBTB48² MYNN² HIC2² ZBTB42² ZBTB46² ZBTB8B² ZBTB17²

5 SIMAP similar genes for ZBTB18 using alignment to 1 protein entry: ZBT18_HUMAN:

ZNF ZNF702P ZBTB42 ZNF844 ZBTB3

ZBTB18 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12027747^1,2	C,F	--	214596775(+)	`TCCCGC/TTGGCT`	1	--	us2k¹		3		WA NA EA	358
rs150737317^1,2		--	214596943(+)	`TACGTA/GAAGAT`	1	--	us2k¹		0	--	--	--	--
rs139094371^1,2		--	214597108(+)	`TAAACA/TGTCAC`	1	--	us2k¹		0	--	--	--	--
rs181059151^1,2	C	--	214597333(+)	`GTCGGC/GTTTTG`	1	--	us2k¹		0	--	--	--	--
rs115135055^1,2	F	--	214597507(+)	`GTACCG/AGTCAG`	1	--	us2k¹		1		WA	118
rs183742608^1,2		--	214597611(+)	`CCACAC/TAAAGA`	1	--	us2k¹		0	--	--	--	--
rs2453189^1,2	C,H	--	214597685(+)	`ACACAG/CATCAA`	1	--	us2k¹ tfbs³		4		NS EA	414
rs78753716^1,2	C,F	--	214597928(+)	`ATTACA/GTAAGA`	1	--	us2k¹		2		NA	122
rs6429447^1,2	C,F,A,H	--	214598005(+)	`GTATAC/ACATTA`	1	--	us2k¹		13		NS EA NA WA	1632
rs188799858^1,2		--	214598024(+)	`GAAAAA/GAATAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZBTB18 (244214561 - 244220778 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for ZBTB18: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZBTB18

DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608433
OMIM disorders: 612337
UniProtKB/Swiss-Prot: ZBT18_HUMAN, Q99592

Mental retardation, autosomal dominant 22 (MRD22) [MIM:612337]: A disorder characterized by significantly

below average general intellectual functioning associated with impairments in adaptive behavior and manifested

during the developmental period. Additional MRD22 patients have limited or no speech, and variable but

characteristic facial features, including round face, prominent forehead, flat nasal bridge, hypertelorism,

epicanthal folds, and low-set ears. Other features may include hypotonia, poor growth, microcephaly, agenesis of

the corpus callosum, and seizures. Note=The disease is caused by mutations affecting the gene represented in this

entry

5 diseases for ZBTB18: About MalaCards

mental retardation, autosomal dominant 22 barth syndrome cerebritis neuronitis

malaria

ZBTB18 for disorders About GeneDecksing

Export disorders for ZBTB18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ZBTB18 gene, integrated from 10 sources (see all 34):
(articles sorted by number of sources associating them with ZBTB18)

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Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin. (PubMed id 10721697)^{1, 2, 9} Meng G....Kasai M. (Gene 2000)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. (PubMed id 11350943)^{1, 2} Fuks F.... Kouzarides T. (EMBO J. 2001)
RP58 associates with condensed chromatin and mediates a sequence- specific transcriptional repression. (PubMed id 9756912)^{1, 2} Aoki K.... Kasai M. (J. Biol. Chem. 1998)
C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain. (PubMed id 9568537)^{1, 3} Becker K.G....Drew P.D. (Int. J. Dev. Neurosci. 1997)
Isolation and characterization of a cDNA encoding a translin-like protein, TRAX. (PubMed id 9013868)^{1, 3} Aoki K.... Kasai M. (FEBS Lett. 1997)
Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. (PubMed id 7633419)^{1, 2} Becker K.G....Drew P.D. (Hum. Mol. Genet. 1995)
Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)¹ Tan M.K....Harper J.W. (Mol. Cell 2013)
A de novo non-sense mutation in ZBTB18 in a patient with features of the 1q43q44 microdeletion syndrome. (PubMed id 24193349)² de Munnik S.A....Brunner H.G. (Eur. J. Hum. Genet. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10472	HGNC: 13030	AceView: ZNF238	Ensembl:ENSG00000179456	euGenes: HUgn10472
ECgene: ZBTB18	H-InvDB: ZBTB18

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ZBTB18	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZBTB18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZBTB18 gene:
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ZBTB18 Gene

Zinc Finger And BTB Domain Containing 18

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ZBTB18 Gene

Zinc Finger And BTB Domain Containing 18

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