ZBTB18 Gene

Aliases
for ZBTB18 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Summaries
for ZBTB18 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZBTB18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10  NT_167186.2  NC_018912.2  

SwitchGear Promoter luciferase reporter plasmid: ZBTB18 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB18

ZBTB18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P244216:  view genomic region     (about GC identifiers)

Proteins
for ZBTB18 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZBTB18: NX_Q99592

Explore proteomics data for ZBTB18 at MOPED

Post-translational modifications: 

ZBTB18 Human Recombinant Protein Products:

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	antibodies-online peptides for ZBTB18

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Domains /
Families
for ZBTB18 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q99592

Find genes that share domains with ZBTB18           About GenesLikeMe

Function
for ZBTB18 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 5 molecular function terms:    About this table

(inferred from 3 alleles) (MGI details for Zbtb18)

genOway: Develop your customized and physiologically relevant rodent model for ZBTB18

		Selected GeneGlobe predicted Target genes for ZBTB18 (see all 441):
		ABCD2,  ABHD13,  ABI2,  ABTB2,  ADCYAP1R1,  AHCYL2,  AHSA1,  AIDA,  AKAP11,  AKR7A2

miRNA Products:		miRTarBase miRNAs that target ZBTB18: hsa-mir-106b-3p (MIRT038588), hsa-mir-548b-3p (MIRT016240), hsa-mir-590-3p (MIRT016212), hsa-mir-215-5p (MIRT024510), hsa-mir-128-3p (MIRT021920), hsa-mir-192-5p (MIRT026265), hsa-mir-26b-5p (MIRT029041), hsa-mir-338-3p (MIRT003042), hsa-mir-877-3p (MIRT036898)
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Gene Editing Products:

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB18

Localization
for ZBTB18 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for ZBTB18 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

Drugs & Compounds
for ZBTB18 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZBTB18 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZBTB18 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZBTB18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Brain (Nervous System)    fully expand to see all 18 entries
Thalamus
cerebellum
Neural Tube (Nervous System)
Telencephalon

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB18

Orthologs
for ZBTB18 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZBTB18 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZBTB18 gene

ZBTB10²  ZBTB3²  ZBTB8A²  ZBTB44²  ZBTB5²  ENSG00000254553²  ZBTB49²  HIC1²  

ZBTB48²  MYNN²  HIC2²  ZBTB42²  ZBTB46²  ZBTB8B²  ZBTB17²  

5 SIMAP similar genes for ZBTB18 using alignment to 1 protein entry:     ZBT18_HUMAN:

ZNF    ZNF702P    ZBTB42    ZNF844    ZBTB3

Find genes that share paralogs with ZBTB18           About GenesLikeMe

Genomic Variants
for ZBTB18 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZBTB18 (see all 185)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs120277471,2	C,F	--	214596775(+)	TCCCGC/TTGGCT	1	--	us2k1		3		WA NA EA	358
rs1507373171,2		--	214596943(+)	TACGTA/GAAGAT	1	--	us2k1		0	--	--	--	--
rs1390943711,2		--	214597108(+)	TAAACA/TGTCAC	1	--	us2k1		0	--	--	--	--
rs1810591511,2	C	--	214597333(+)	GTCGGC/GTTTTG	1	--	us2k1		0	--	--	--	--
rs1151350551,2	F	--	214597507(+)	GTACCG/AGTCAG	1	--	us2k1		1		WA	118
rs1837426081,2		--	214597611(+)	CCACAC/TAAAGA	1	--	us2k1		0	--	--	--	--
rs24531891,2	C,H	--	214597685(+)	ACACAG/CATCAA	1	--	us2k1 tfbs3		4		NS EA	414
rs787537161,2	C,F	--	214597928(+)	ATTACA/GTAAGA	1	--	us2k1		2		NA	122
rs64294471,2	C,F,A,H	--	214598005(+)	GTATAC/ACATTA	1	--	us2k1		13		NS EA NA WA	1632
rs1887998581,2		--	214598024(+)	GAAAAA/GAATAA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZBTB18 (244214561 - 244220778 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ZBTB18: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZBTB18

DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB18

Disorders / Diseases
for ZBTB18 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZBTB18 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin. (PubMed id 10721697)^{1, 2, 9} Meng G....Kasai M. (Gene 2000)
2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. (PubMed id 11350943)^{1, 2} Fuks F.... Kouzarides T. (EMBO J. 2001)
5. RP58 associates with condensed chromatin and mediates a sequence- specific transcriptional repression. (PubMed id 9756912)^{1, 2} Aoki K.... Kasai M. (J. Biol. Chem. 1998)
6. C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain. (PubMed id 9568537)^{1, 3} Becker K.G....Drew P.D. (Int. J. Dev. Neurosci. 1997)
7. Isolation and characterization of a cDNA encoding a translin-like protein, TRAX. (PubMed id 9013868)^{1, 3} Aoki K.... Kasai M. (FEBS Lett. 1997)
8. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. (PubMed id 7633419)^{1, 2} Becker K.G....Drew P.D. (Hum. Mol. Genet. 1995)
9. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)¹ Tan M.K....Harper J.W. (Mol. Cell 2013)
10. A de novo non-sense mutation in ZBTB18 in a patient with features of the 1q43q44 microdeletion syndrome. (PubMed id 24193349)² de Munnik S.A....Brunner H.G. (Eur. J. Hum. Genet. 2013)

External Searches for ZBTB18 gene

Genome Databases showing ZBTB18 gene

Other Databases showing ZBTB18 gene

Specialized Databases showing ZBTB18 gene

Products
for ZBTB18 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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