ZBTB17 Gene
protein-coding GIFtS : 56
GC01M016140
zinc finger and BTB domain containing 17 (Previous names: zinc finger protein 151 (pHZ-67), zinc finger protein 60 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: ZNF151, ZNF60 )
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Aliases & Descriptions for ZBTB17
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MIZ-1 2 MIZ1 1 , 3 Miz-1 3 OTTHUMP00000010985 2 ZNF151 2 , 3 ZNF60 2 , 3 pHZ-67 1 , 2
Descriptions Myc-interacting Zn finger protein-1 2 Myc-interacting zinc finger protein 3 Zinc finger protein 151 3 Zinc finger protein 60 1 , 2 , 3 zinc finger and BTB domain containing 17 2 zinc finger protein 151 (pHZ-67) 1 , 2
Search outside databases for aliases for ZBTB17 genePrevious GC identifer: GC01M016013
Summaries for ZBTB17 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ZBTB17 : This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 hasalso been associated with PIAS2 which is a different gene located on chromosome 18. [provided byRefSeq] UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105 Function : May function as a housekeeping DNA-binding protein that regulates the expression ofspecific genes. Has been shown to bind to the promoters of adenovirus major late protein andcyclin D1 and activate transcription. Also has potent growth arrest activity, probably throughinhibition of cell cycle progression. Required for early embryonic development during gastrulation
Gene Wiki entry for ZBTB17
Genomic Location for ZBTB17
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ZBTB17 gene Entrez Gene cytogenetic band: 1p36.2-p36.1 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13 ZBTB17 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M016140:
(about GC identifiers )
Start:
16,140,951 bp from pter
End:
16,175,191 bp from pter
Size:
34,241 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004873.16 Proteins for ZBTB17
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105 (See
protein sequence )Recommended Name: Zinc finger and BTB domain-containing protein 17 Size : 803 amino acids; 87928 Da
Subunit : Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17transactivation and growth arrest activities and renders it insoluble in the nucleus. Alsointeracts with HCFC1, MAGEA4 and TMPRSS11A
Subcellular location : Nucleus
PDB structures from and Proteopedia : 2Q81 (3D)
 
Secondary accessions : A0AV07 Q15932 Q5JYB2 Q9NUC9Alternative splicing : 2 isoforms : Q13105-1 Q13105-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_003434.2 ENSEMBL proteins: ENSP00000364881 ENSP00000364885 ENSP00000364895 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ZBTB17: Assays for ZBTB17:
Protein
Domains/ Families for ZBTB17(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q13105 ProtoNet protein and cluster: Q13105
2 Blocks protein families : IPB000210 BTB/POZ domain IPB007086 C2H2-type zinc finger signature UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 1 BTB (POZ) domainSimilarity : Contains 13 C2H2-type zinc fingers
Gene Function for ZBTB17
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003443 Applied Biosystems Silencer ® siRNAs for ZBTB17 Sigma-Aldrich siRNA and siRNA Panels for ZBTB17 Sigma-Aldrich shRNA for ZBTB17 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003443                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003443                                  untagged cDNA clone in CMV expression vector: NM_003443  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003443 UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105 Function : May function as a housekeeping DNA-binding protein that regulates the expression ofspecific genes. Has been shown to bind to the promoters of adenovirus major late protein andcyclin D1 and activate transcription. Also has potent growth arrest activity, probably throughinhibition of cell cycle progression. Required for early embryonic development during gastrulation
6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Zbtb17) :4 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for ZBTB17
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for ZBTB17 5/26 Interacting proteins for ZBTB17 (Q13105 1 ENSP00000364885 3 ) via UniProtKB, MINT, and/or STRING (see all 26
)About this table 5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
):
GO ID Qualified GO term Evidence PubMed IDs GO:0001702 gastrulation with mouth forming second
IEA -- GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007275 multicellular organismal development
IEA -- GO:0007398 ectoderm development
IEA --
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Drugs & Compounds for ZBTB17 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ZBTB17 1 Novoseek chemical compound relationship for ZBTB17 gene
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Transcripts for ZBTB17(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003443 Sigma-Aldrich siRNA and siRNA Panels for ZBTB17 Sigma-Aldrich shRNA for ZBTB17 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_003443
REFSEQ mRNAs for ZBTB17 gene: NM_003443.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003443
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003443                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003443                                  untagged cDNA clone in CMV expression vector: NM_003443  
Additional cDNA sequence: AK223618.1 AK226168.1 AK294796.1 AK299820.1 AK301896.1 AK302610.1 AK303823.1 AK309081.1 AK311083.1 AK315201.1 BC069790.1 BC126163.1 BC143965.1 BC143968.1 U20647.1 Y09723.1
18 DOTS entries : DT.117648 DT.40111516 DT.99959136 DT.121415121 DT.91754742 DT.446133 DT.91712760 DT.100788908 DT.97827237 DT.95296858 DT.100788911 DT.100788907 DT.97844905 DT.100788906 DT.121415084 DT.121415090 DT.75193200 DT.100670404
24/269 AceView cDNA sequences (see all 269
):NM_003443 BE796930 BU682651 BG235972 BU846294 BQ680310 BM725629 AL702979 BQ575263 CK300604 AA775292 AI083818 CA450001 CB851110 BE504547 AA860766 BI772046 AW078602 BQ100822 CB852031 BI831817 BQ187277 BE206151 BE646354
highest scoring ESTs for ZBTB17 :AL701220 AL702979 AL703111 BE276394 BE387205 BE796930 BF203373 BG680776 BG772259 BI756616
Unigene Cluster for ZBTB17: Zinc finger and BTB domain containing 17 Hs.433764 [show with all ESTs ] Unigene Representative Sequence: NM_003443 GeneLoc Exon Structure 5/23 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB17 (see all 23
) ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ SP1 :             -   -   -     -   -   -   -   -     -   -       -   -   -   -       SP2 :                                                     SP3 :             -   -   -     -   -   -   -   -     -   -                   SP4 :             -   -   -     -   -   -   -   -     -   -                   SP5 :             -   -       -   -   -   -   -     -   -                  
ExUns: 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 SP1 :                                             SP2 :               -               -   -     -   -         SP3 :                                             SP4 :                                             SP5 :                                            
About this scheme ECgene alternative splicing isoforms for ZBTB17 3 Ensembl transcripts including schematic representations : ENST00000375729
ENST00000375733
ENST00000375743
Expression for ZBTB17
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ZBTB17 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB17 1 / 2 / 3
5 probe-sets matching ZBTB17 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTCCAGACAGSOURCE GeneReport for Unigene cluster: Hs.433764 Expression variation in blood from EXPOLDB for ZBTB17
Orthologs for ZBTB17
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ZBTB17 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ZBTB17 ENSEMBL Gene Tree for ZBTB17 Paralogs for ZBTB17 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ZBTB17 gene ZNF238 2 ZBTB3 2 ZNF509 2
SNPs/Variants for ZBTB17 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ZBTB17 (up to first 250kb)
Disorders & Mutations for ZBTB17
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604084
Medical News for ZBTB17 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ZBTB17 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/47 PubMed articles for ZBTB17 gene (see all 47
): An alternative pathway for gene regulation by Myc. (PubMed id 9312026) 1, 3, 4 Peukert K....Eilers M. (1997) Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PubMed id 12244100) 1, 3, 4 Piluso D.... Capone J.P. (2002) A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. (PubMed id 14739298) 1, 3, 4 Sakurai T.... Fujita J. (2004) Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. (PubMed id 9308237) 1, 3, 4 Schneider A.... Haenel F. (1997) A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain. (PubMed id 17880999) 1, 3, 4 Stead M.A....Wright S.C. (2007) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Myc represses differentiation-induced p21CIP1 expression via Miz-1- dependent interaction with the p21 core promoter. (PubMed id 12545156) 3, 4 Wu S.... Larsson L.-G. (2003) Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. (PubMed id 7557990) 3, 4 Tommerup N. and Vissing H. (1995) Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991) 3, 4 Lichter P....Ward D.C. (1992)
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Genome Databases showing ZBTB17
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ZBTB17
(According to HUGE )
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Specialized Databases showing ZBTB17 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ZBTB17 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ZBTB17:
Recombinant Proteins (Miz1 ) Antibodies (Miz1 )
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