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Aliases for ZBTB17 Gene

Aliases for ZBTB17 Gene

  • Zinc Finger And BTB Domain Containing 17 2 3 5
  • Zinc Finger Protein 60 2 3 4
  • Zinc Finger Protein 151 (PHZ-67) 2 3
  • ZNF151 3 4
  • MIZ-1 3 4
  • ZNF60 3 4
  • Zinc Finger And BTB Domain-Containing Protein 17 3
  • Myc-Interacting Zinc Finger Protein 1 4
  • Myc-Interacting Zn Finger Protein-1 3
  • Zinc Finger Protein 151 4
  • PHZ-67 3
  • MIZ1 4

External Ids for ZBTB17 Gene

Previous HGNC Symbols for ZBTB17 Gene

  • ZNF151
  • ZNF60

Previous GeneCards Identifiers for ZBTB17 Gene

  • GC01M016013
  • GC01M016140
  • GC01M016268
  • GC01M014787

Summaries for ZBTB17 Gene

Entrez Gene Summary for ZBTB17 Gene

  • This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZBTB17 Gene

ZBTB17 (Zinc Finger And BTB Domain Containing 17) is a Protein Coding gene. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZBTB49.

UniProtKB/Swiss-Prot for ZBTB17 Gene

  • Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).

Gene Wiki entry for ZBTB17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB17 Gene

Genomics for ZBTB17 Gene

Regulatory Elements for ZBTB17 Gene

Enhancers for ZBTB17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F016902 1.2 FANTOM5 ENCODE 19.6 -928.9 -928918 4.9 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZFP41 MFAP2 ENSG00000224621 RPL22P3 EIF1AXP1 ZBTB17 RCC2 RSG1 NBPF1 FBXO42 LINC01772
GH01F015947 1.8 FANTOM5 Ensembl ENCODE 17.8 +24.9 24875 7.5 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 FOS ZNF263 SP3 JUNB HSPB7 CLCNKA PLEKHM2 ZBTB17 LINC01772 ENSG00000233078 SPEN FBLIM1 C1orf64 CLCNKB
GH01F016348 0.8 FANTOM5 ENCODE 17.5 -374.8 -374840 5.5 CREB3L1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 GLIS1 ENSG00000237938 FBXO42 RPL22P3 ZBTB17 SPEN ARHGEF19 MFAP2 ANO7L1 RPS16P1 ENSG00000224621
GH01F015961 1.6 FANTOM5 Ensembl ENCODE 13.1 +11.5 11481 5.9 HDGF TBP PKNOX1 TBL1XR1 YBX1 BMI1 RAD21 ZNF121 EGR1 ETV6 CLCNKA PLEKHM2 ZBTB17 CLCNKB CASP9 SZRD1 SPEN ENSG00000234607 GC01P015946
GH01F015829 1.3 FANTOM5 Ensembl ENCODE 12.8 +142.1 142132 10.0 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 FAM231A ENSG00000237938 CD24P1 RNU1-1 CLCNKA FLJ37453 SPEN ZBTB17 HSPB7 RPL22P3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZBTB17 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000279608 432 1801 HDGF PKNOX1 ARNT MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ZBTB17 Gene

Chromosome:
1
Start:
15,941,869 bp from pter
End:
15,976,132 bp from pter
Size:
34,264 bases
Orientation:
Minus strand

Genomic View for ZBTB17 Gene

Genes around ZBTB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB17 Gene

Proteins for ZBTB17 Gene

  • Protein details for ZBTB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13105-ZBT17_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 17
    Protein Accession:
    Q13105
    Secondary Accessions:
    • A0AV07
    • B4DXB4
    • B7ZLQ9
    • F5H411
    • Q15932
    • Q5JYB2
    • Q9NUC9

    Protein attributes for ZBTB17 Gene

    Size:
    803 amino acids
    Molecular mass:
    87928 Da
    Quaternary structure:
    • Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1 (PubMed:25245946).

    Three dimensional structures from OCA and Proteopedia for ZBTB17 Gene

    Alternative splice isoforms for ZBTB17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB17 Gene

Post-translational modifications for ZBTB17 Gene

  • Undergoes Lys-48-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a TRAF2-dependent manner.
  • Ubiquitination at Lys 397 and Lys 481
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for ZBTB17 (Miz-1/ZBTB17)
  • Cell Signaling Technology (CST) Antibodies for ZBTB17 (ZBTB17)

No data available for DME Specific Peptides for ZBTB17 Gene

Domains & Families for ZBTB17 Gene

Gene Families for ZBTB17 Gene

Suggested Antigen Peptide Sequences for ZBTB17 Gene

Graphical View of Domain Structure for InterPro Entry

Q13105

UniProtKB/Swiss-Prot:

ZBT17_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB17: view

Function for ZBTB17 Gene

Molecular function for ZBTB17 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).

Gene Ontology (GO) - Molecular Function for ZBTB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 12244100
GO:0005515 protein binding IPI 9308237
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB17: view
genes like me logo Genes that share phenotypes with ZBTB17: view

Animal Models for ZBTB17 Gene

MGI Knock Outs for ZBTB17:

Animal Model Products

miRNA for ZBTB17 Gene

miRTarBase miRNAs that target ZBTB17

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZBTB17 Gene

Localization for ZBTB17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB17 Gene COMPARTMENTS Subcellular localization image for ZBTB17 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ZBTB17: view

Pathways & Interactions for ZBTB17 Gene

genes like me logo Genes that share pathways with ZBTB17: view

Gene Ontology (GO) - Biological Process for ZBTB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007398 ectoderm development IEA --
genes like me logo Genes that share ontologies with ZBTB17: view

No data available for SIGNOR curated interactions for ZBTB17 Gene

Drugs & Compounds for ZBTB17 Gene

(1) Drugs for ZBTB17 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231
genes like me logo Genes that share compounds with ZBTB17: view

Transcripts for ZBTB17 Gene

Unigene Clusters for ZBTB17 Gene

Zinc finger and BTB domain containing 17:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^
SP1: - - - - - - - - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - -
SP15:
SP16: - - - - - -
SP17: - - -
SP18: - - - - - -
SP19:
SP20: - - - -
SP21:
SP22:
SP23:

ExUns: 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2: - - - - -
SP3:
SP4:
SP5:
SP6: -
SP7: - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - -
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23: -

Relevant External Links for ZBTB17 Gene

GeneLoc Exon Structure for
ZBTB17
ECgene alternative splicing isoforms for
ZBTB17

Expression for ZBTB17 Gene

mRNA expression in normal human tissues for ZBTB17 Gene

Protein differential expression in normal tissues from HIPED for ZBTB17 Gene

This gene is overexpressed in Platelet (43.9) and Adrenal (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB17 Gene



Protein tissue co-expression partners for ZBTB17 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB17 Gene:

ZBTB17

SOURCE GeneReport for Unigene cluster for ZBTB17 Gene:

Hs.433764

mRNA Expression by UniProt/SwissProt for ZBTB17 Gene:

Q13105-ZBT17_HUMAN
Tissue specificity: Expressed in germinal center B-cells.
genes like me logo Genes that share expression patterns with ZBTB17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZBTB17 Gene

Orthologs for ZBTB17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB17 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia ZBTB17 34 35
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia ZBTB17 34 35
  • 90.13 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb17 34
  • 86.82 (n)
mouse
(Mus musculus)
Mammalia Zbtb17 34 16 35
  • 86.02 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB17 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB17 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB17 34 35
  • 76.37 (n)
lizard
(Anolis carolinensis)
Reptilia ZBTB17 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb17 34
  • 72.35 (n)
Str.20427 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14330 34
zebrafish
(Danio rerio)
Actinopterygii zbtb17 35
  • 61 (a)
OneToOne
LOC564967 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5542 35
  • 17 (a)
OneToOne
Species where no ortholog for ZBTB17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB17 Gene

ENSEMBL:
Gene Tree for ZBTB17 (if available)
TreeFam:
Gene Tree for ZBTB17 (if available)

Paralogs for ZBTB17 Gene

Paralogs for ZBTB17 Gene

(315) SIMAP similar genes for ZBTB17 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZBTB17: view

Variants for ZBTB17 Gene

Sequence variations from dbSNP and Humsavar for ZBTB17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10927875 -- 15,972,817(+) AAAGG(C/T)GTGAG intron-variant
rs111380200 -- 15,945,875(+) TGCTA(C/T)CCTCT intron-variant
rs111570427 -- 15,962,865(+) GAGGC(C/T)GGGAG intron-variant
rs111617386 -- 15,960,152(+) TCCCA(G/T)GACCC intron-variant
rs111638515 -- 15,946,751(+) CTCCC(A/G)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB17 Gene

Variant ID Type Subtype PubMed ID
nsv508936 CNV insertion 20534489
nsv833647 CNV loss 17160897
nsv833758 CNV gain+loss 17160897
nsv954843 CNV deletion 24416366

Variation tolerance for ZBTB17 Gene

Residual Variation Intolerance Score: 9.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB17 Gene

Disorders for ZBTB17 Gene

Relevant External Links for ZBTB17

Genetic Association Database (GAD)
ZBTB17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB17

No disorders were found for ZBTB17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB17 Gene

Publications for ZBTB17 Gene

  1. A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain. (PMID: 17880999) Stead M.A. … Wright S.C. (J. Mol. Biol. 2007) 3 4 22 64
  2. A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. (PMID: 14739298) Sakurai T. … Fujita J. (J. Biol. Chem. 2004) 3 4 22 64
  3. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PMID: 12244100) Piluso D. … Capone J.P. (J. Biol. Chem. 2002) 3 4 22 64
  4. Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. (PMID: 9308237) Schneider A. … Haenel F. (Curr. Top. Microbiol. Immunol. 1997) 3 4 22 64
  5. An alternative pathway for gene regulation by Myc. (PMID: 9312026) Peukert K. … Eilers M. (EMBO J. 1997) 3 4 22 64

Products for ZBTB17 Gene

Sources for ZBTB17 Gene

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