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ZBTB17 Gene

protein-coding   GIFtS: 58
GCID: GC01M016268

Zinc Finger And BTB Domain Containing 17

(Previous names: zinc finger protein 151 (pHZ-67), zinc finger protein 6...)
(Previous symbols: ZNF151, ZNF60)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 171 2     Myc-Interacting Zn Finger Protein-12
ZNF1511 2 3 5     pHZ-672
Zinc Finger Protein 601 2 3     Zinc Finger And BTB Domain-Containing Protein 172
ZNF601 2 3     Miz-13
Zinc Finger Protein 151 (PHZ-67)1 2     Myc-Interacting Zinc Finger Protein 13
MIZ13 5     Zinc Finger Protein 1513
MIZ-12     

External Ids:    HGNC: 129361   Entrez Gene: 77092   Ensembl: ENSG000001168097   OMIM: 6040845   UniProtKB: Q131053   

Export aliases for ZBTB17 gene to outside databases

Previous GC identifers: GC01M016013 GC01M016140 GC01M014787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZBTB17 Gene:
This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been
associated with PIAS2 which is a different gene located on chromosome 18. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZBTB17 Gene:
ZBTB17 (zinc finger and BTB domain containing 17) is a protein-coding gene. Diseases associated with ZBTB17 include diffuse large b-cell lymphoma, and dilated cardiomyopathy. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB10.

UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105
Function: Transcription factor that can function as an activator or repressor depending on its binding partners,
and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte
development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in
response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus
major late protein and cyclin D1 and activate transcription. Required for early embryonic development during
gastrulation

Gene Wiki entry for ZBTB17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB17 gene promoter:
         c-Fos   GR   Max1   USF1   AP-1   CUTL1   SRY   USF-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB17 promoter sequence
   Search Chromatin IP Primers for ZBTB17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

ZBTB17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB17 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M016268:  view genomic region     (about GC identifiers)

Start:
16,268,364 bp from pter      End:
16,302,627 bp from pter
Size:
34,264 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 17  
Size: 803 amino acids; 87928 Da
Subunit: Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via
the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and
CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to
TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif);
the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the
nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17
transactivation activity on target genes involved in cell cycle arrest
Selected PDB 3D structures from and Proteopedia for ZBTB17 (see all 8):
2LVR (3D)        2LVT (3D)        2LVU (3D)        2M0D (3D)        2M0E (3D)        2M0F (3D)    
Secondary accessions: A0AV07 B4DXB4 B7ZLQ9 F5H411 Q15932 Q5JYB2 Q9NUC9
Alternative splicing: 3 isoforms:  Q13105-1   Q13105-2   Q13105-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZBTB17: NX_Q13105

Explore proteomics data for ZBTB17 at MOPED

Post-translational modifications: 

  • Undergoes 'Lys-48'-linked polyubiquitination at Lys-397 and Lys-481 and subsequent proteasomal degradation in a
    TRAF2-dependent manner (By similarity)1
  • Ubiquitination2 at Lys397, Lys481
  • Modification sites at PhosphoSitePlus

  • See ZBTB17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229813.1  NP_001274532.1  NP_001274533.1  NP_003434.2  

    ENSEMBL proteins: 
     ENSP00000400827   ENSP00000364895   ENSP00000408483   ENSP00000364885   ENSP00000438529  
     ENSP00000391002  
    Reactome Protein details: Q13105

    ZBTB17 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ZBTB17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q13105

    ProtoNet protein and cluster: Q13105

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 13 C2H2-type zinc fingers


    ZBTB17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT17_HUMAN, Q13105
    Function: Transcription factor that can function as an activator or repressor depending on its binding partners,
    and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte
    development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in
    response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus
    major late protein and cyclin D1 and activate transcription. Required for early embryonic development during
    gastrulation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA12244100
    GO:0005515protein binding IPI12244100
    GO:0046872metal ion binding IEA--
         
    ZBTB17 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Zbtb17):
     cellular  embryogenesis  growth/size/body  hematopoietic system  immune system 
     integument  mortality/aging  pigmentation 

    ZBTB17 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zbtb17tm1Elr for ZBTB17

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB17
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB17

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    GenScript: all cDNA clones in your preferred vector: ZBTB17 (NM_003443)
    Sino Biological Human cDNA Clone for ZBTB17
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB17

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT17_HUMAN, Q13105: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    ZBTB17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZBTB17 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Cell cycle
    Cell cycle0.59
    3Cell Cycle / Checkpoint Control
    DNA Damage0.32
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ZBTB17
        Molecular Mechanisms of Cancer
    JAK-STAT Pathway

    2 Cell Signaling Technology (CST) Pathways for ZBTB17
        Lymphocyte Signaling
    DNA Damage

    3 BioSystems Pathways for ZBTB17
        Regulation of nuclear SMAD2/3 signaling
    Validated targets of C-MYC transcriptional repression
    C-MYC pathway


    1 Reactome Pathway for ZBTB17
        XBP1(S) activates chaperone genes


    2 Kegg Pathways  (Kegg details for ZBTB17):
        Cell cycle
    Transcriptional misregulation in cancer


    ZBTB17 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB17
    Interactions:

        GeneGlobe Interaction Network for ZBTB17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ZBTB17 (Q131051, 2, 3 ENSP000003648954) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011061, 2, 3, ENSP000003672074EBI-372156,EBI-447544 MINT-7296688 MINT-7296709 I2D: score=7 STRING: ENSP00000367207
    TOPBP1Q925471, 2, 3, ENSP000002608104EBI-372156,EBI-308302 MINT-7296657 MINT-7296688 I2D: score=4 STRING: ENSP00000260810
    HCFC1P516101, 3, ENSP000003095554EBI-372156,EBI-396176 I2D: score=4 STRING: ENSP00000309555
    MAGEA4P433581, 3, ENSP000002763444EBI-372156,EBI-743122 I2D: score=1 STRING: ENSP00000276344
    YWHAHQ049172, 3, ENSP000002489754MINT-8006807 MINT-8006814 I2D: score=1 STRING: ENSP00000248975
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007398ectoderm development IEA--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--

    ZBTB17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB17 (ZBT17)

    1 HMDB Compound for ZBTB17    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    1 Novoseek inferred chemical compound relationship for ZBTB17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 42.6 9 16380648 (1), 11545736 (1), 12904288 (1), 15794748 (1) (see all 6)



    ZBTB17 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZBTB17 gene (4 alternative transcripts): 
    NM_001242884.1  NM_001287603.1  NM_001287604.1  NM_003443.2  

    Unigene Cluster for ZBTB17:

    Zinc finger and BTB domain containing 17
    Hs.433764  [show with all ESTs]
    Unigene Representative Sequence: NM_003443
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462525 ENST00000440560 ENST00000375743 ENST00000444358 ENST00000488008
    ENST00000471805 ENST00000472658 ENST00000474511 ENST00000487785 ENST00000492834
    ENST00000490899 ENST00000464719 ENST00000479282(uc010obv.1) ENST00000494020
    ENST00000375733(uc001axl.4 uc010obq.2 uc010obr.2 uc010obs.2 uc009vom.1 uc009von.1)
    ENST00000537142 ENST00000448462(uc010obt.1 uc010obu.2)
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    Additional mRNA sequence: 

    AK223618.1 AK226168.1 AK294796.1 AK299820.1 AK301896.1 AK302610.1 AK303823.1 AK309081.1 
    AK311083.1 AK315201.1 BC069790.1 BC126163.1 BC143965.1 BC143968.1 U20647.1 Y09723.1 

    16 DOTS entries:

    DT.117648  DT.40111516  DT.99959136  DT.121415121  DT.91712760  DT.97827237  DT.95296858  DT.100788908 
    DT.100788911  DT.100788907  DT.97844905  DT.100788906  DT.121415084  DT.121415090  DT.75193200  DT.100670404 

    Selected AceView cDNA sequences (see all 269):

    BQ101050 BU188758 AI457388 AI083818 BE796930 BE504547 BU846294 BI826023 
    BQ100779 BM725629 BQ100763 CK823120 AA860766 U20647 BI772046 BU634371 
    BI822188 BQ680310 AA775292 BM669290 BQ187277 BU191409 BQ575263 CB851110 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB17 (see all 23)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^
    SP1:                                      -     -     -           -     -     -     -     -           -     -                 -     -     -     -               
    SP2:                                                                                                                                                            
    SP3:                                      -     -     -           -     -     -     -     -           -     -                                                   
    SP4:                                      -     -     -           -     -     -     -     -           -     -                                                   
    SP5:                                      -     -                 -     -     -     -     -           -     -                                                   

    ExUns: 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                                                                                                                                    
    SP2:                                            -                                         -     -           -     -                     
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ZBTB17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCAGACAG
    ZBTB17 Expression
    About this image

    ZBTB17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433764

    UniProtKB/Swiss-Prot: ZBT17_HUMAN, Q13105
    Tissue specificity: Expressed in germinal center B-cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB17 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb171 , 5 zinc finger and BTB domain containing 171, 5 86.02(n)1
    91.94(a)1
      4 (74.17 cM)5
    226421  NM_009541.21  NP_033567.21 
     1414446545 
    chicken
    (Gallus gallus)
    Aves ZBTB171 zinc finger and BTB domain containing 17 76.37(n)
    77.95(a)
      396541  NM_001276300.1  NP_001263229.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB176
    zinc finger and BTB domain containing 17
    65(a)
    1 ↔ 1
    GL343609.1(307026-332318)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143302 Xenopus laevis transcribed sequence with moderate similarity more 81.43(n)    BX847300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5649671 zinc finger and BTB domain-containing protein 17-like   --   564967  XM_003201203.2  XP_003201251.1 


    ENSEMBL Gene Tree for ZBTB17 (if available)
    TreeFam Gene Tree for ZBTB17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB17 gene
    ZBTB102  ZBTB32  ZBTB182  ZBTB8A2  ZBTB442  ZBTB52  ENSG000002545532  HIC12  
    ZBTB492  ZBTB482  MYNN2  HIC22  ZBTB422  ZBTB462  ZBTB8B2  
    Selected SIMAP similar genes for ZBTB17 using alignment to 4 protein entries:     ZBT17_HUMAN (see all proteins) (see all similar genes):
    ZBTB7C    ZBTB25    KLHL32    ZNF55    ZBTB4    ZNF78L1
    BACH2    ZFS-5    ZNF141    ZNF426    ZNF514    ZNF93
    ZNF    ZIK1    ZNF562    ZNF606    ZNF701    ZNF782

    ZBTB17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB17 (see all 693)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823372871,2
    --16268093(+) GGAGGC/GCAGGC 2 -- int10--------
    rs1877442961,2
    --16268148(+) GGGCAC/TGGGGC 2 -- int10--------
    rs1478628731,2
    --16268240(+) TAGTCA/GCATTC 2 -- int10--------
    rs1996203661,2
    --16268436(+) ATCCT-/TAAA  
            
    TAAAC
    2 -- ut310--------
    rs2002039381,2
    C--16268545(+) CGAGGG/CCGGAA 4 /R syn11Minor allele frequency- C:0.00EU 1293
    rs1927512971,2
    --16268569(+) GCCTGC/TAGCAC 4 L syn10--------
    rs1999662801,2
    --16268593(+) CACGTA/GCCACC 4 G syn10--------
    rs1475165391,2
    C--16268644(+) ATGACC/TAGTGC 4 L syn11Minor allele frequency- T:0.00NA 4550
    rs2011129351,2
    --16268656(+) TGGGCC/TGTGTG 4 T syn10--------
    rs1512697601,2
    F--16268725(+) CAGGCG/ATAGAG 4 /Y syn11Minor allele frequency- A:0.00NA 4550

    HapMap Linkage Disequilibrium report for ZBTB17 (16268364 - 16302627 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZBTB17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508936CNV Insertion20534489
    dgv174n71CNV Loss21882294
    nsv833647CNV Loss17160897
    nsv871162CNV Gain21882294
    nsv833758CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604084    OMIM disorders: --

    8 diseases for ZBTB17:    
    About MalaCards
    diffuse large b-cell lymphoma    dilated cardiomyopathy    esophageal cancer    b-cell lymphomas
    meningitis    neuroblastoma    esophagitis    leukemia


    ZBTB17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZBTB17

    Export disorders for ZBTB17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB17 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with ZBTB17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An alternative pathway for gene regulation by Myc. (PubMed id 9312026)1, 2, 9 Peukert K....Eilers M. (EMBO J. 1997)
    2. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. (PubMed id 12244100)1, 2, 9 Piluso D.... Capone J.P. (J. Biol. Chem. 2002)
    3. A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. (PubMed id 14739298)1, 2, 9 Sakurai T.... Fujita J. (J. Biol. Chem. 2004)
    4. Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc. (PubMed id 9308237)1, 2, 9 Schneider A.... Haenel F. (Curr. Top. Microbiol. Immunol. 1997)
    5. A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain. (PubMed id 17880999)1, 2, 9 Stead M.A.... Wright S.C. (J. Mol. Biol. 2007)
    6. A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. (PubMed id 21459883)1, 4 Villard E.... Cambien F. (Eur. Heart J. 2011)
    7. Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1. (PubMed id 19164764)1, 2 Basu S.... Dong F. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1. (PubMed id 15095404)1, 2 Zhao N.... Lu S.-H. (J. Cell. Biochem. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7709 HGNC: 12936 AceView: ZBTB17 Ensembl:ENSG00000116809 euGenes: HUgn7709
    ECgene: ZBTB17 Kegg: 7709 H-InvDB: ZBTB17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ZBTB17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB17 gene:
    Search GeneIP for patents involving ZBTB17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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