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Aliases for ZBTB16 Gene

Aliases for ZBTB16 Gene

  • Zinc Finger And BTB Domain Containing 16 2 3
  • ZNF145 3 4 6
  • PLZF 3 4 6
  • Zinc Finger Protein 145 (Kruppel-Like, Expressed In Promyelocytic Leukemia) 2 3
  • Promyelocytic Leukaemia Zinc Finger 2 3
  • Zinc Finger Protein PLZF 3 4
  • Zinc Finger And BTB Domain-Containing Protein 16 3
  • Promyelocytic Leukemia Zinc Finger Protein 4
  • Zinc Finger Protein 145 4

External Ids for ZBTB16 Gene

Previous HGNC Symbols for ZBTB16 Gene

  • ZNF145

Previous GeneCards Identifiers for ZBTB16 Gene

  • GC11P113435
  • GC11P113930
  • GC11P109859

Summaries for ZBTB16 Gene

Entrez Gene Summary for ZBTB16 Gene

  • This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZBTB16 Gene

ZBTB16 (Zinc Finger And BTB Domain Containing 16) is a Protein Coding gene. Diseases associated with ZBTB16 include skeletal defects, genital hypoplasia, and mental retardation and leukemia, acute promyelocytic. Among its related pathways are Class I MHC mediated antigen processing and presentation and Pathways in cancer. GO annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is ZBTB32.

UniProtKB/Swiss-Prot for ZBTB16 Gene

  • Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ZBTB16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB16 Gene

Genomics for ZBTB16 Gene

Regulatory Elements for ZBTB16 Gene

Transcription factor binding sites by QIAGEN in the ZBTB16 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB16 Gene

Start:
114,059,567 bp from pter
End:
114,250,676 bp from pter
Size:
191,110 bases
Orientation:
Plus strand

Genomic View for ZBTB16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB16 Gene

Proteins for ZBTB16 Gene

  • Protein details for ZBTB16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05516-ZBT16_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 16
    Protein Accession:
    Q05516
    Secondary Accessions:
    • Q8TAL4

    Protein attributes for ZBTB16 Gene

    Size:
    673 amino acids
    Molecular mass:
    74274 Da
    Quaternary structure:
    • Binds EPN1. Interacts with ZBTB32 and CUL3.

    Three dimensional structures from OCA and Proteopedia for ZBTB16 Gene

    Alternative splice isoforms for ZBTB16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB16 Gene

Proteomics data for ZBTB16 Gene at MOPED

Post-translational modifications for ZBTB16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB16 Gene

No data available for DME Specific Peptides for ZBTB16 Gene

Domains for ZBTB16 Gene

Gene Families for ZBTB16 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZBTB16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05516

UniProtKB/Swiss-Prot:

ZBT16_HUMAN :
  • Q05516
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB16: view

Function for ZBTB16 Gene

Molecular function for ZBTB16 Gene

UniProtKB/Swiss-Prot Function: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
UniProtKB/Swiss-Prot Induction: By retinoic acid

Gene Ontology (GO) - Molecular Function for ZBTB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 12802276
GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 12802276
GO:0003677 DNA binding NAS 9294197
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with ZBTB16: view
genes like me logo Genes that share phenotypes with ZBTB16: view

Animal Models for ZBTB16 Gene

MGI Knock Outs for ZBTB16:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZBTB16 Gene

Localization for ZBTB16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB16 Gene COMPARTMENTS Subcellular localization image for ZBTB16 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBTB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0016604 nuclear body IDA 19648967
genes like me logo Genes that share ontologies with ZBTB16: view

Pathways for ZBTB16 Gene

genes like me logo Genes that share pathways with ZBTB16: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q05516-ZBT16_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ZBTB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 12802276
GO:0001501 skeletal system development --
GO:0001823 mesonephros development ISS 8541544
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with ZBTB16: view

Compounds for ZBTB16 Gene

(1) HMDB Compounds for ZBTB16 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(6) Novoseek inferred chemical compound relationships for ZBTB16 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 76.4 27
zinc 73.8 57
retinoid 43.4 1
progesterone 0 3
tyrosine 0 2
genes like me logo Genes that share compounds with ZBTB16: view

Transcripts for ZBTB16 Gene

Unigene Clusters for ZBTB16 Gene

Zinc finger and BTB domain containing 16:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB16

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for ZBTB16 Gene

GeneLoc Exon Structure for
ZBTB16
ECgene alternative splicing isoforms for
ZBTB16

Expression for ZBTB16 Gene

mRNA expression in normal human tissues for ZBTB16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBTB16 Gene

SOURCE GeneReport for Unigene cluster for ZBTB16 Gene Hs.591945

mRNA Expression by UniProt/SwissProt for ZBTB16 Gene

Q05516-ZBT16_HUMAN
Tissue specificity: Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung
genes like me logo Genes that share expressions with ZBTB16: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZBTB16 Gene

Orthologs for ZBTB16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB16 35
  • 98.83 (n)
  • 98.67 (a)
ZBTB16 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB16 35
  • 91.83 (n)
  • 96.14 (a)
ZBTB16 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB16 35
  • 92.37 (n)
  • 95.99 (a)
ZBTB16 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb16 35
  • 90.49 (n)
  • 96.73 (a)
Zbtb16 16
Zbtb16 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB16 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb16 35
  • 90.54 (n)
  • 96.14 (a)
chicken
(Gallus gallus)
Aves ZBTB16 35
  • 81 (n)
  • 87.82 (a)
ZBTB16 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB16 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9134 35
zbtb16 35
  • 73.33 (n)
  • 79.85 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb93g12 35
zbtb16a 35
  • 75.5 (n)
  • 80.57 (a)
zbtb16a 36
  • 68 (a)
OneToMany
zbtb16b 36
  • 71 (a)
OneToMany
Species with no ortholog for ZBTB16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB16 Gene

ENSEMBL:
Gene Tree for ZBTB16 (if available)
TreeFam:
Gene Tree for ZBTB16 (if available)

Paralogs for ZBTB16 Gene

Paralogs for ZBTB16 Gene

genes like me logo Genes that share paralogs with ZBTB16: view

Variants for ZBTB16 Gene

Sequence variations from dbSNP and Humsavar for ZBTB16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs120744 -- 114,234,646(-) TTAGG(A/G)CTCAC intron-variant
rs238887 -- 114,127,880(-) CTTAG(C/G)TGCGC intron-variant
rs238888 -- 114,127,759(-) GTGGA(C/T)GGAAG intron-variant
rs238889 -- 114,127,272(-) CTGCA(A/G)TGGAA intron-variant
rs238890 -- 114,124,852(-) CACCC(C/T)CGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB16 Gene

Variant ID Type Subtype PubMed ID
nsv826091 CNV Gain 20364138
nsv521857 CNV Loss 19592680
nsv498 CNV Loss 18451855
esv2001202 CNV Deletion 18987734

Relevant External Links for ZBTB16 Gene

HapMap Linkage Disequilibrium report
ZBTB16
Human Gene Mutation Database (HGMD)
ZBTB16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB16 Gene

Disorders for ZBTB16 Gene

(1) OMIM Diseases for ZBTB16 Gene (176797)

UniProtKB/Swiss-Prot

ZBT16_HUMAN
  • Skeletal defects, genital hypoplasia, and mental retardation (SGYMR) [MIM:612447]: A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia. {ECO:0000269 PubMed:18611983}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA.

(1) University of Copenhagen DISEASES for ZBTB16 Gene

(10) Novoseek inferred disease relationships for ZBTB16 Gene

Disease -log(P) Hits PubMed IDs
promyelocytic leukemia 90.8 46
leukemia promyelocytic acute 89.9 23
leukemogenesis 64.8 2
leukemia 58.9 16
fanconis anemia 36 2

Relevant External Links for ZBTB16

Genetic Association Database (GAD)
ZBTB16
Human Genome Epidemiology (HuGE) Navigator
ZBTB16
genes like me logo Genes that share disorders with ZBTB16: view

Publications for ZBTB16 Gene

  1. Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. (PMID: 8384553) Chen Z. … Zelent A. (EMBO J. 1993) 3 4 23
  2. Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. (PMID: 8387545) Chen S.-J. … Chen Z. (J. Clin. Invest. 1993) 3 4 23
  3. Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. (PMID: 10500192) Zhang T. … Chen S.-J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  4. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. (PMID: 10688654) Melnick A.M. … Licht J.D. (Mol. Cell. Biol. 2000) 3 23
  5. Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF. (PMID: 11175338) Dhordain P. … Koken M.H. (Oncogene 2000) 3 23

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