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ZBTB16 Gene

protein-coding GIFtS: 65

GC11P113435

zinc finger and BTB domain containing 16
(Previous names: zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ZNF145)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
PLZF ^¹, ², ³, ⁵
ZNF145 ^², ³, ⁵

Descriptions
Promyelocytic leukemia zinc finger protein ^², ³
Zinc finger protein 145 ^³
Zinc finger protein PLZF ^³
zinc finger and BTB domain containing 16 ^²
zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia) ^¹, ²

External Ids
HGNC: 12930¹
Entrez Gene: 7704²
UniProtKB: Q05516³
Ensembl: ENSG00000109906⁷

Search outside databases for aliases for ZBTB16 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ZBTB16:

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc

finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl

terminus. This protein is located in the nucleus, is involved in cell cycle progression, and

interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this

locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional

splice variants have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: ZBT16_HUMAN, Q05516

Function: Probable transcription factor. May play a role in myeloid maturation and in the

development and/or maintenance of other differentiated tissues. Probable substrate-recognition

component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and

subsequent proteasomal degradation of target proteins

Gene Wiki entry for ZBTB16 (Zinc_finger_and_BTB_domain-containing_protein_16)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB16 gene

Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23

ZBTB16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P113435: (about GC identifiers)

Start:	113,435,525 bp from pter
End:	113,626,608 bp from pter
Size:	191,084 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT16_HUMAN, Q05516 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 16

Size: 673 amino acids; 74274 Da

Subunit: Binds EPN1. Interacts with ZBTB32 and CUL3

Subcellular location: Nucleus

PDB structure from and Proteopedia :

1BUO (3D)

1CS3 (3D)

Secondary accessions: Q8TAL4

Alternative splicing: 2 isoforms: Q05516-1 Q05516-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001018011.1 NP_005997.2

ENSEMBL proteins:

ENSP00000338157 ENSP00000376721 ENSP00000309507

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Plzf)
	Human Recombinant Proteins from Abnova (ZBTB16)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IDA	9294197
GO:0005730	nucleolus	IDA	18029348
GO:0016605	PML body	IDA	9294197
GO:0016607	nuclear speck	IDA	8541544

About this table

Antibodies for ZBTB16:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB16
	R&D Systems Antibodies for ZBTB16 (PLZF)
	Antibodies from Abcam (Plzf), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBTB16)
	Novus Biologicals Antibodies for ZBTB16

Assays for ZBTB16:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q05516

ProtoNet protein and cluster: Q05516

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZBT16_HUMAN, Q05516

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 9 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB16)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB16)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001018011

Applied Biosystems Silencer® siRNAs for ZBTB16

Sigma-Aldrich siRNA and siRNA Panels for ZBTB16

Sigma-Aldrich shRNA Panels and shRNA for ZBTB16

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018011
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018011
untagged cDNA clones in CMV expression vector (see all 2): NM_001018011

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006006

UniProtKB/Swiss-Prot: ZBT16_HUMAN, Q05516

Function: Probable transcription factor. May play a role in myeloid maturation and in the

development and/or maintenance of other differentiated tissues. Probable substrate-recognition

component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and

subsequent proteasomal degradation of target proteins

Induction: By retinoic acid

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Zbtb16):

endocrine/exocrine gland

limbs/digits/tail

reproductive system

skeleton

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	9294197
GO:0008270	zinc ion binding	IEA	--
GO:0016566	specific transcriptional repressor activity	IDA	12802276
GO:0042803	protein homodimerization activity	IDA	8622986
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ZBTB16 (Your Favorite Gene powered by Ingenuity)

RAR Activation

GeneDecks ZBTB16 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: ZBT16_HUMAN, Q05516

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for ZBTB16

5/60 Interacting proteins for ZBTB16 (Q05516¹ ENSP00000338157³) via UniProtKB, MINT, and/or STRING (see all 60 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PML	Q15959¹, ENSP00000268058³	EBI-711925, EBI-779712 STRING (score=.994)
EEF1A1	P68104¹	EBI-711925, EBI-352162
ZBTB16	Q05516¹	EBI-711925, EBI-711925
NCOR2	ENSP00000348551³	STRING (score=.999)
HDAC1	ENSP00000362649³	STRING (score=.997)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001823	mesonephros development	ISS	8541544
GO:0006350	transcription	IEA	--
GO:0006915	apoptosis	NAS	9294197
GO:0007417	central nervous system development	ISS	8541544
GO:0019941	modification-dependent protein catabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB16
3 Novoseek chemical compound relationships for ZBTB16 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	73.99	82	18953495 (2), 10544010 (2), 17340613 (2), 11175338 (2) (see all 41)
progesterone	0.00	5	12970399 (3)
tyrosine	0.00	1	9717842 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB16)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB16)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001018011

Sigma-Aldrich siRNA and siRNA Panels for ZBTB16

Sigma-Aldrich shRNA Panels and shRNA for ZBTB16

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001018011 NM_006006

REFSEQ mRNAs for ZBTB16 gene (2 alternative transcripts):

NM_001018011.1 NM_006006.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001018011 NM_006006

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018011
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018011
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001018011

Additional cDNA sequence: AK126422.1

9 DOTS entries:

DT.95361449 DT.411134 DT.95200997 DT.92420387 DT.120730770 DT.99964205 DT.120730737 DT.92420386

DT.95073700

24/74 AceView cDNA sequences (see all 74 ):

BC026902 BX280946 BM969145 AW954317 BX955225 BQ943253 BU731767 BG820096

BQ185051 BQ184859 BM873474 CB990313 CD621505 AI198303 BM677752 BQ187781

CD518150 NM_006006 CB268674 BC029812 AW960240 AI933117 CB961332 BG914153

highest scoring ESTs for ZBTB16:

AA296152 AA468119 AA642184 AA845269 AI198303 AI832425 AI937150 AW960240 BC026902 BC029812

Unigene Clusters for ZBTB16:

Zinc finger and BTB domain containing 16

Hs.591945 [show with all ESTs], Hs.682144 [show with all ESTs]

Unigene Representative Sequences: BX648973, AK126422

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB16

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b
SP1:							-		-										-		-
SP2:									-										-		-
SP3:
SP4:							-		-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for ZBTB16

3 Ensembl transcripts including schematic representations:

ENST00000335953 ENST00000392996 ENST00000310883

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZBTB16 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB16

¹ / ² / ³

3 probe-sets matching ZBTB16 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39681_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF060568	0.20	1.00	0.72	1
205883_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006006	0.60	1.00	0.82	1
205883_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGGTTTTCA

SOURCE GeneReport for Unigene clusters: Hs.591945 Hs.682144
Expression variation in blood from EXPOLDB for ZBTB16
UniProtKB/Swiss-Prot: ZBT16_HUMAN, Q05516
Tissue specificity: Within the hematopoietic system, PLZF is expressed in bone marrow, early
myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at
lower levels, in the kidney and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB16 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB16¹	--	zinc finger and BTB domain containing 16	92.37(n) 95.99(a)	489398 XM_546516.2 XP_546516.2
cow (Bos taurus)	ZBTB16¹	--	zinc finger and BTB domain containing 16	91.83(n) 96.14(a)	534401 NM_001037476.1 NP_001032553.1
rat (Rattus norvegicus)	Zbtb16¹	--	zinc finger and BTB domain containing 16	90.54(n) 96.14(a)	353227 NM_001013181.1 NP_001013199.1
mouse (Mus musculus)	Zbtb16^{1, 5}	9 (23.00 cM)⁵	zinc finger and BTB domain containing 16^{1, 5}	90.49(n)¹ 96.73(a)¹	235320¹ NM_001033324.2¹ NP_001028496.1¹ AI467657⁵ AK040211⁵ (see all 10)
chicken (Gallus gallus)	ZBTB16¹	--	zinc finger and BTB domain containing 16	81.01(n) 87.73(a)	419759 XM_417898.2 XP_417898.2

About this table Species with no ortholog for ZBTB16

ENSEMBL Gene Tree for ZBTB16

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB16 gene

ZBTB39² ZBTB32²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1306 NCBI SNPs in ZBTB16 are shown (see all 1306 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 564)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11214855^1,2	A,C,F,H	113434071(+)	`CTTTCT/CCTGCT`	1	--	ng5¹		3		EU EA	298
	rs1350248^1,2	A,C,F	113433692(-)	`TGCTGG/TAGGTT`	1	--	ng5¹		1		MN	184
--	rs6589410^1,2	A,C,F	113433694(+)	`CCTCCA/GGCAGG`	1	--	ng5¹		3		NA	130
	rs11214857^1,2	A,C	113434760(+)	`GGGGTA/GGGATG`	2	--	ng5¹		0	--	--	--	--
--	rs6589411^1,2	A,C	113435968(+)	`GCCGCC/TGCAGC`	2	--	int¹ ng5¹		0	--	--	--	--
	rs12290993^1,2	F,H	113626688(+)	`GGGGCC/TTCCAC`	2	--	ng3¹		4		EU EA WA	412
--	rs11214915^1,2	A	113626593(+)	`aaaaaC/Gagaag`	2	--	ut3¹		0	--	--	--	--
	rs3088357^1,2	F	113626502(+)	`CGCGGC/TGGTGG`	2	--	ut3¹ ese³		1		MN	184
--	rs1047222^1,2	H	113623244(+)	`CTGTGG/ACAAGA`	2	D/G	mis¹ ese³		5		MN EU EA WA	586
	rs35616762^1,2	F	113439631(+)	`GACACG/AGAGGC`	2	T/T	syn¹		1		NA	78

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HapMap Linkage Disequilibrium images for ZBTB16 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176797

UniProtKB/Swiss-Prot: ZBT16_HUMAN, Q05516

Defects in ZBTB16 are the cause of skeletal defects genital hypoplasia and mental

retardation [MIM:612447]. The disorder is characterized by mental retardation, craniofacial

dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs,

hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital

hypoplasia

A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia

(APL). Translocation t(11;17)(q32;q21) with RARA

10 Novoseek disease relationships for ZBTB16 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia promyelocytic acute	90.56	25	10023668 (1), 7849296 (1), 7892256 (1), 9341182 (1) (see all 23)
promyelocytic leukemia	90.44	64	14527952 (3), 18953495 (2), 17118363 (2), 10980608 (2) (see all 35)
leukemogenesis	66.32	3	8622986 (1), 17217037 (1)
leukemia	59.69	18	9591778 (2), 12970399 (2), 11090081 (1), 12802276 (1) (see all 13)
fanconis anemia	38.29	2	11865059 (1), 17171645 (1)
acute leukemia	9.28	1	15467736 (1)
lymphoma non-hodgkins	8.87	2	10207085 (1), 11175338 (1)
cancer	0.00	3	12188922 (1), 18246121 (1), 17537403 (1)
tumors	0.00	7	10980608 (2), 18246121 (1), 16828757 (1)
prostate cancer	0.00	3	15065091 (2), 15334066 (1)

About this table

Human Gene Mutation Database: ZBTB16
Genetic Association Database: ZBTB16
Human Genome Epidemiology Navigator: ZBTB16 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/142 PubMed articles for ZBTB16 gene (see all 142 ):

Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. (PubMed id 10500192)^{1, 3, 4} Zhang T.... Chen S.-J. (1999)
Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. (PubMed id 8387545)^{1, 3, 4} Chen S.-J.... Chen Z. (1993)
Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. (PubMed id 8384553)^{1, 3, 4} Chen Z.... Zelent A. (1993)
Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. (PubMed id 10537309)^{1, 3, 4} Li X....Marmorstein R. (1999)
Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia. (PubMed id 18611983)^{3, 4} Fischer S....Wieczorek D. (2008)
[Role of molecular screening for common fusion genes in the diagnosis and classification of leukemia] (PubMed id 15968309)^{3, 6} Zhu Y.L....Liu J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. (PubMed id 11161217)^{3, 4} Itoh T.... Takenawa T. (2001)
A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. (PubMed id 10572087)^{3, 4} Hoatlin M.E.... Licht J.D. (1999)
Crystal structure of the BTB domain from PLZF. (PubMed id 9770450)^{3, 4} Ahmad K.F.... Prive G.G. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7704	HGNC: 12930	AceView: ZBTB16	Ensembl:ENSG00000109906	euGenes: HUgn7704
ECgene: ZBTB16	H-InvDB: ZBTB16

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ZBTB16	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ZBTB16
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB16:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB16-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB16		Antibodies for ZBTB16
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB16		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBTB16)
	Antibodies (ZBTB16)
	Chimera RNAi (ZBTB16)
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Antibodies for ZBTB16

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ZBTB16 Gene at Home site.
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ZBTB16 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ZBTB16

Summaries
for ZBTB16

Genomic Location
for ZBTB16

Proteins
for ZBTB16

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Families
for ZBTB16

Gene Function
for ZBTB16

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for ZBTB16

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Transcripts
for ZBTB16

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for ZBTB16

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for ZBTB16

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB16 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ZBTB16

Summariesfor ZBTB16

Genomic Locationfor ZBTB16

Proteinsfor ZBTB16

Protein Domains/Familiesfor ZBTB16

Gene Functionfor ZBTB16

Pathways & Interactionsfor ZBTB16

Drugs & Compoundsfor ZBTB16

Transcriptsfor ZBTB16

Expression for ZBTB16

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SNPs/Variantsfor ZBTB16

Disorders & Mutationsfor ZBTB16

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Search for ZBTB16

Genome Databases showing ZBTB16

Other Databases showing ZBTB16

Specialized Databases showing ZBTB16

Licensable Technologiesfor ZBTB16

Servicesfor ZBTB16

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB16

Summaries
for ZBTB16

Genomic Location
for ZBTB16

Proteins
for ZBTB16

Protein Domains/
Families
for ZBTB16

Gene Function
for ZBTB16

Pathways & Interactions
for ZBTB16

Drugs & Compounds
for ZBTB16

Transcripts
for ZBTB16

Expression
for ZBTB16

Orthologs
for ZBTB16

Paralogs
for ZBTB16

SNPs/Variants
for ZBTB16

Disorders & Mutations
for ZBTB16

Medical News
for ZBTB16

Publications
for ZBTB16

Licensable Technologies
for ZBTB16

Services
for ZBTB16