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Aliases for ZBTB16 Gene

Aliases for ZBTB16 Gene

  • Zinc Finger And BTB Domain Containing 16 2 3 5
  • Zinc Finger Protein 145 (Kruppel-Like, Expressed In Promyelocytic Leukemia) 2 3
  • Promyelocytic Leukaemia Zinc Finger 2 3
  • Zinc Finger Protein PLZF 3 4
  • ZNF145 3 4
  • PLZF 3 4
  • Promyelocytic Leukemia Zinc Finger Protein 4
  • Zinc Finger Protein 145 4

External Ids for ZBTB16 Gene

Previous HGNC Symbols for ZBTB16 Gene

  • ZNF145

Previous GeneCards Identifiers for ZBTB16 Gene

  • GC11P113435
  • GC11P113930
  • GC11P109859

Summaries for ZBTB16 Gene

Entrez Gene Summary for ZBTB16 Gene

  • This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZBTB16 Gene

ZBTB16 (Zinc Finger And BTB Domain Containing 16) is a Protein Coding gene. Diseases associated with ZBTB16 include skeletal defects, genital hypoplasia, and mental retardation and leukemia, acute promyelocytic, somatic. Among its related pathways are Immune System and Pathways in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding. An important paralog of this gene is ZBTB32.

UniProtKB/Swiss-Prot for ZBTB16 Gene

  • Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ZBTB16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB16 Gene

Genomics for ZBTB16 Gene

Regulatory Elements for ZBTB16 Gene

Promoters for ZBTB16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB16 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZBTB16 gene promoter:

Genomic Location for ZBTB16 Gene

Chromosome:
11
Start:
114,059,579 bp from pter
End:
114,250,676 bp from pter
Size:
191,098 bases
Orientation:
Plus strand

Genomic View for ZBTB16 Gene

Genes around ZBTB16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB16 Gene

Proteins for ZBTB16 Gene

  • Protein details for ZBTB16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05516-ZBT16_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 16
    Protein Accession:
    Q05516
    Secondary Accessions:
    • Q8TAL4

    Protein attributes for ZBTB16 Gene

    Size:
    673 amino acids
    Molecular mass:
    74274 Da
    Quaternary structure:
    • Binds EPN1. Interacts with ZBTB32 and CUL3.

    Three dimensional structures from OCA and Proteopedia for ZBTB16 Gene

    Alternative splice isoforms for ZBTB16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB16 Gene

Proteomics data for ZBTB16 Gene at MOPED

Post-translational modifications for ZBTB16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB16 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ZBTB16 (PLZF)

No data available for DME Specific Peptides for ZBTB16 Gene

Domains & Families for ZBTB16 Gene

Gene Families for ZBTB16 Gene

Graphical View of Domain Structure for InterPro Entry

Q05516

UniProtKB/Swiss-Prot:

ZBT16_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB16: view

Function for ZBTB16 Gene

Molecular function for ZBTB16 Gene

UniProtKB/Swiss-Prot Function:
Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Gene Ontology (GO) - Molecular Function for ZBTB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IDA 12802276
genes like me logo Genes that share ontologies with ZBTB16: view
genes like me logo Genes that share phenotypes with ZBTB16: view

Human Phenotype Ontology for ZBTB16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZBTB16 Gene

MGI Knock Outs for ZBTB16:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZBTB16 Gene

Localization for ZBTB16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB16 Gene COMPARTMENTS Subcellular localization image for ZBTB16 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ZBTB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ZBTB16: view

Pathways & Interactions for ZBTB16 Gene

genes like me logo Genes that share pathways with ZBTB16: view

UniProtKB/Swiss-Prot Q05516-ZBT16_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ZBTB16 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ZBTB16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001823 mesonephros development ISS 8541544
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process NAS 9294197
GO:0009880 embryonic pattern specification IEA --
genes like me logo Genes that share ontologies with ZBTB16: view

Drugs & Compounds for ZBTB16 Gene

(4) Drugs for ZBTB16 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477

(2) Additional Compounds for ZBTB16 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZBTB16: view

Transcripts for ZBTB16 Gene

Unigene Clusters for ZBTB16 Gene

Zinc finger and BTB domain containing 16:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - -
SP2: - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for ZBTB16 Gene

GeneLoc Exon Structure for
ZBTB16
ECgene alternative splicing isoforms for
ZBTB16

Expression for ZBTB16 Gene

mRNA expression in normal human tissues for ZBTB16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.4), Ovary (21.0), NK cells (11.9), and Liver (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB16 Gene



SOURCE GeneReport for Unigene cluster for ZBTB16 Gene Hs.591945

mRNA Expression by UniProt/SwissProt for ZBTB16 Gene

Q05516-ZBT16_HUMAN
Tissue specificity: Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
genes like me logo Genes that share expression patterns with ZBTB16: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ZBTB16 Gene

Orthologs for ZBTB16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB16 35
  • 91.83 (n)
  • 96.14 (a)
ZBTB16 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB16 35
  • 92.37 (n)
  • 95.99 (a)
ZBTB16 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb16 35
  • 90.49 (n)
  • 96.73 (a)
Zbtb16 16
Zbtb16 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB16 35
  • 98.83 (n)
  • 98.67 (a)
ZBTB16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb16 35
  • 90.54 (n)
  • 96.14 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBTB16 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB16 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB16 35
  • 81 (n)
  • 87.82 (a)
ZBTB16 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB16 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb16 35
  • 73.33 (n)
  • 79.85 (a)
Str.9134 35
zebrafish
(Danio rerio)
Actinopterygii wufb93g12 35
zbtb16a 35
  • 75.5 (n)
  • 80.57 (a)
zbtb16a 36
  • 68 (a)
OneToMany
zbtb16b 36
  • 71 (a)
OneToMany
Species with no ortholog for ZBTB16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB16 Gene

ENSEMBL:
Gene Tree for ZBTB16 (if available)
TreeFam:
Gene Tree for ZBTB16 (if available)

Paralogs for ZBTB16 Gene

Paralogs for ZBTB16 Gene

genes like me logo Genes that share paralogs with ZBTB16: view

Variants for ZBTB16 Gene

Sequence variations from dbSNP and Humsavar for ZBTB16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_054912 Skeletal defects, genital hypoplasia, and mental retardation (SGYMR)
rs120744 -- 114,234,646(-) TTAGG(A/G)CTCAC intron-variant
rs410804 -- 114,235,713(+) ctttc(C/T)ttctt intron-variant
rs415066 -- 114,238,720(-) CTGCA(C/T)ATGCC intron-variant
rs364729 -- 114,224,721(-) tcctc(A/G)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB16 Gene

Variant ID Type Subtype PubMed ID
nsv826091 CNV Gain 20364138
nsv521857 CNV Loss 19592680
nsv498 CNV Loss 18451855
esv2001202 CNV Deletion 18987734

Variation tolerance for ZBTB16 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB16 Gene

HapMap Linkage Disequilibrium report
ZBTB16
Human Gene Mutation Database (HGMD)
ZBTB16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB16 Gene

Disorders for ZBTB16 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZBTB16 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZBT16_HUMAN
  • Note=A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA. {ECO:0000269 PubMed:8384553}.
  • Skeletal defects, genital hypoplasia, and mental retardation (SGYMR) [MIM:612447]: A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia. {ECO:0000269 PubMed:18611983}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZBTB16

Genetic Association Database (GAD)
ZBTB16
Human Genome Epidemiology (HuGE) Navigator
ZBTB16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB16
genes like me logo Genes that share disorders with ZBTB16: view

No data available for Genatlas for ZBTB16 Gene

Publications for ZBTB16 Gene

  1. Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. (PMID: 10500192) Zhang T. … Chen S.-J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23 67
  2. Generation of PLZF+ CD4+ T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans. (PMID: 20038602) Lee Y.J. … Park S.H. (J. Exp. Med. 2010) 3 23
  3. PLZF-mediated control on c-kit expression in CD34(+) cells and early erythropoiesis. (PMID: 19421145) Spinello I. … Labbaye C. (Oncogene 2009) 3 23
  4. A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis. (PMID: 18568019) Labbaye C. … Peschle C. (Nat. Cell Biol. 2008) 3 23
  5. The alpha subunit of Go interacts with promyelocytic leukemia zinc finger protein and modulates its functions. (PMID: 18262754) Won J.H. … Ghil S.H. (Cell. Signal. 2008) 3 23

Products for ZBTB16 Gene

Sources for ZBTB16 Gene

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