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Aliases for ZBTB14 Gene

Aliases for ZBTB14 Gene

  • Zinc Finger And BTB Domain Containing 14 2 3
  • ZFP161 3 4 6
  • ZF5 3 4 6
  • Zinc Finger Protein 161 Homolog 3 4
  • Zinc Finger Protein 5 Homolog 3 4
  • ZFP161 Zinc Finger Protein 2 3
  • Zinc Finger Protein 478 3 4
  • ZFP-161 3 4
  • ZNF478 3 4
  • ZFP-5 3 4
  • Zinc Finger Protein Homologous To Zfp161 In Mouse 3
  • Zinc Finger And BTB Domain-Containing Protein 14 3
  • Zinc Finger Protein 161 Homolog (Mouse) 2
  • Zinc Finger Protein 161 2
  • HZF5 4

External Ids for ZBTB14 Gene

Previous HGNC Symbols for ZBTB14 Gene

  • ZFP161

Summaries for ZBTB14 Gene

GeneCards Summary for ZBTB14 Gene

ZBTB14 (Zinc Finger And BTB Domain Containing 14) is a Protein Coding gene. An important paralog of this gene is ZBTB7B.

UniProtKB/Swiss-Prot for ZBTB14 Gene

  • Transcriptional activator of the dopamine transporter (DAT), binding its promoter at the consensus sequence 5-CCTGCACAGTTCACGGA-3. Binds to 5-d(GCC)(n)-3 trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.

Gene Wiki entry for ZBTB14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB14 Gene

Genomics for ZBTB14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB14 Gene

Start:
5,289,019 bp from pter
End:
5,297,053 bp from pter
Size:
8,035 bases
Orientation:
Minus strand

Genomic View for ZBTB14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB14 Gene

No data available for Regulatory Elements for ZBTB14 Gene

Proteins for ZBTB14 Gene

  • Protein details for ZBTB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43829-ZBT14_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 14
    Protein Accession:
    O43829
    Secondary Accessions:
    • O00403
    • Q2TB80

    Protein attributes for ZBTB14 Gene

    Size:
    449 amino acids
    Molecular mass:
    50956 Da
    Quaternary structure:
    • Interacts with ZBTB21.

neXtProt entry for ZBTB14 Gene

Proteomics data for ZBTB14 Gene at MOPED

Post-translational modifications for ZBTB14 Gene

  • Ubiquitination at Lys24
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZBTB14 Gene

Domains for ZBTB14 Gene

Gene Families for ZBTB14 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry

O43829

UniProtKB/Swiss-Prot:

ZBT14_HUMAN :
  • O43829
Domain:
  • The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB14: view

No data available for Suggested Antigen Peptide Sequences for ZBTB14 Gene

Function for ZBTB14 Gene

Molecular function for ZBTB14 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator of the dopamine transporter (DAT), binding its promoter at the consensus sequence 5-CCTGCACAGTTCACGGA-3. Binds to 5-d(GCC)(n)-3 trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.

Gene Ontology (GO) - Molecular Function for ZBTB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 17714511
GO:0005515 protein binding IPI 15629158
GO:0043565 sequence-specific DNA binding IDA 17714511
GO:0044212 transcription regulatory region DNA binding IDA 17714511
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB14: view

Phenotypes for ZBTB14 Gene

genes like me logo Genes that share phenotypes with ZBTB14: view

Animal Model Products

CRISPR Products

miRNA for ZBTB14 Gene

miRTarBase miRNAs that target ZBTB14

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB14 Gene

Localization for ZBTB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB14 Gene

Nucleus. Note=Colocalizes with ZBTB21 in nucleus in HEK293 cells.

Gene Ontology (GO) - Cellular Components for ZBTB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17714511
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB14: view

No data available for Subcellular locations from COMPARTMENTS for ZBTB14 Gene

Pathways for ZBTB14 Gene

SuperPathways for ZBTB14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8367294
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IMP 17714511
genes like me logo Genes that share ontologies with ZBTB14: view

No data available for Pathways by source for ZBTB14 Gene

Compounds for ZBTB14 Gene

(1) Novoseek inferred chemical compound relationships for ZBTB14 Gene

Compound -log(P) Hits PubMed IDs
zinc 62.6 10
genes like me logo Genes that share compounds with ZBTB14: view

Transcripts for ZBTB14 Gene

Unigene Clusters for ZBTB14 Gene

Zinc finger and BTB domain containing 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB14

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB14 Gene

No ASD Table

Relevant External Links for ZBTB14 Gene

GeneLoc Exon Structure for
ZBTB14
ECgene alternative splicing isoforms for
ZBTB14

Expression for ZBTB14 Gene

mRNA expression in normal human tissues for ZBTB14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBTB14 Gene

SOURCE GeneReport for Unigene cluster for ZBTB14 Gene Hs.592340

genes like me logo Genes that share expressions with ZBTB14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB14 Gene

Orthologs for ZBTB14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB14 36
  • 100 (a)
OneToOne
ZFP161 35
  • 98.81 (n)
  • 99.11 (a)
cow
(Bos Taurus)
Mammalia ZBTB14 35
  • 85.6 (n)
  • 99.33 (a)
ZBTB14 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB14 35
  • 92.58 (n)
  • 99.78 (a)
ZBTB14 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb14 35
  • 87.6 (n)
  • 99.33 (a)
Zbtb14 16
Zbtb14 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB14 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB14 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp161 35
  • 87.16 (n)
  • 99.11 (a)
chicken
(Gallus gallus)
Aves ZFP161 35
  • 82.4 (n)
  • 95.75 (a)
ZFP161 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB14 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19698 35
zbtb14 35
  • 77.4 (n)
  • 90.6 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12466 35
zebrafish
(Danio rerio)
Actinopterygii wufd57e03 35
zbtb14 35
  • 70.55 (n)
  • 78.08 (a)
zbtb14 36
  • 76 (a)
OneToOne
Species with no ortholog for ZBTB14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB14 Gene

ENSEMBL:
Gene Tree for ZBTB14 (if available)
TreeFam:
Gene Tree for ZBTB14 (if available)

Paralogs for ZBTB14 Gene

Paralogs for ZBTB14 Gene

Pseudogenes.org Pseudogenes for ZBTB14 Gene

genes like me logo Genes that share paralogs with ZBTB14: view

Variants for ZBTB14 Gene

Sequence variations from dbSNP and Humsavar for ZBTB14 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs2789 -- 5,289,888(+) CCCCA(C/G)AGAGC utr-variant-3-prime
rs12343 -- 5,290,175(+) ATCCC(A/G)GTGGG utr-variant-3-prime
rs12522 -- 5,290,283(-) TGTTT(C/T)TGTGG utr-variant-3-prime
rs567949 -- 5,292,177(+) TTTAA(A/T)GGTTT reference, missense
rs567954 -- 5,292,180(+) AATGG(G/T)TTCAG reference, missense

Relevant External Links for ZBTB14 Gene

HapMap Linkage Disequilibrium report
ZBTB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBTB14 Gene

Disorders for ZBTB14 Gene

No disorders were found for ZBTB14 Gene.

No data available for UniProtKB/Swiss-Prot for ZBTB14 Gene

Publications for ZBTB14 Gene

  1. The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr). (PMID: 9244432) Sobek-Klocke I. … Eichenlaub-Ritter U. (Genomics 1997) 2 3 4 23
  2. Expression cloning and intracellular localization of a human ZF5 homologue. (PMID: 9177479) Sugiura K. … Hagiwara M. (Biochim. Biophys. Acta 1997) 3 4 23
  3. Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter. (PMID: 14706637) Lee K.H. … Lee Y.S. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  4. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. (PMID: 15629158) Wang J. … Shimizu N. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  5. Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Kruppel-like transcription factor ZF5. (PMID: 17714511) Orlov S.V. … Perevozchikov A.P. (FEBS J. 2007) 3 4 23

Products for ZBTB14 Gene

Sources for ZBTB14 Gene

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