Aliases for ZBTB12 Gene
Aliases for ZBTB12 Gene
External Ids for ZBTB12 Gene
- HGNC: 19066
- Entrez Gene: 221527
- Ensembl: ENSG00000204366
- UniProtKB: Q9Y330
Previous HGNC Symbols for ZBTB12 Gene
- C6orf46
Previous GeneCards Identifiers for ZBTB12 Gene
- GC06M031972
- GC06M031975
- GC06M031868
- GC06M031653
Summaries for ZBTB12 Gene
GeneCards Summary for ZBTB12 Gene
ZBTB12 (Zinc Finger And BTB Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is ZBTB26.
UniProtKB/Swiss-Prot for ZBTB12 Gene
-
May be involved in transcriptional regulation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB12 Gene
Genomics for ZBTB12 Gene
Regulatory Elements for ZBTB12 Gene
Enhancers for ZBTB12 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ZBTB12 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZBTB12 gene promoter:
Regulatory Element Products
Genomic Location for ZBTB12 Gene
- Chromosome:
- 6
- Start:
- 31,899,204 bp from pter
- End:
- 31,902,367 bp from pter
- Size:
- 3,164 bases
- Orientation:
- Minus strand
Genomic View for ZBTB12 Gene
Genes around ZBTB12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by Ensembl
- 6p21.33 by Entrez Gene
- 6p21.33 by HGNC
ZBTB12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZBTB12 Gene
Proteins for ZBTB12 Gene
-
Protein details for ZBTB12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y330-ZBT12_HUMAN
- Recommended name:
- Zinc finger and BTB domain-containing protein 12
- Protein Accession:
- Q9Y330
- B0UY00
- Q5JQ98
Protein attributes for ZBTB12 Gene
- Size:
- 459 amino acids
- Molecular mass:
- 49148 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZBTB12 Gene
Post-translational modifications for ZBTB12 Gene
Other Protein References for ZBTB12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZBTB12
- Novus Biologicals Antibodies for ZBTB12
-
Abcam antibodies for ZBTB12
- Invitrogen Antibodies for ZBTB12
- antibodies-online Antibodies for ZBTB12: See all 38
- Search GeneTex for Antibodies for ZBTB12
Protein Products
-
OriGene Purified Proteins for ZBTB12
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBTB12
- Origene Custom Protein Services for ZBTB12
- Search GeneTex for Proteins for ZBTB12
-
Abcam proteins for ZBTB12
No data available for DME Specific Peptides for ZBTB12 Gene
Domains & Families for ZBTB12 Gene
Gene Families for ZBTB12 Gene
Protein Domains for ZBTB12 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZBTB12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZBTB12 Gene
Function for ZBTB12 Gene
Molecular function for ZBTB12 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZBTB12 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZBTB12
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
- Search ViGene Biosciences for ZBTB12
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB12
- GenScript: Design CRISPR guide RNA sequences for ZBTB12
miRNA for ZBTB12 Gene
- miRTarBase miRNAs that target ZBTB12
Targeted motifs for ZBTB12 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB12
- Consensus sequence: NGNTCTAGAACCNGV Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341
miRNA Products
- Search ViGene Biosciences for ZBTB12
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZBTB12
- Browse OriGene Inhibitory RNA Products For ZBTB12
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
Clone Products
-
OriGene ORF clones in human for ZBTB12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZBTB12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZBTB12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ZBTB12
-
ViGene Biosciences adenoviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZBTB12 Gene
Localization for ZBTB12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZBTB12 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for ZBTB12 Gene
No Data Available
Interacting Proteins for ZBTB12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZBTB12 Gene
Transcripts for ZBTB12 Gene
mRNA/cDNA for ZBTB12 Gene
- (2) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZBTB12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB12
- GenScript: Design CRISPR guide RNA sequences for ZBTB12
miRNA Products
- Search ViGene Biosciences for ZBTB12
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ZBTB12
- Browse OriGene Inhibitory RNA Products For ZBTB12
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
Clone Products
-
OriGene ORF clones in human for ZBTB12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZBTB12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZBTB12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for ZBTB12 Gene
This gene is overexpressed in Breast (62.8) and Peripheral blood mononuclear cells (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB12 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZBTB12 Gene:
ZBTB12SOURCE GeneReport for Unigene cluster for ZBTB12 Gene:
Hs.234027Evidence on tissue expression from TISSUES for ZBTB12 Gene
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZBTB12
-
OriGene qPCR primer pairs for ZBTB12
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB12 Gene
Orthologs for ZBTB12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZBTB12 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ZBTB12 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ZBTB12 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zbtb12 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Zbtb12 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZBTB12 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | ZBTB12 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zbtb12 34 |
|
||
| Str.17103 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10817 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zbtb12.2 35 |
|
OneToOne | |
| Dr.14513 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6329 34 |
|
- Species where no ortholog for ZBTB12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZBTB12 Gene
Variants for ZBTB12 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000900895 | -- | 31,899,814(+) | GCCTC(A/C)CACTC | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs1002382850 | -- | 31,899,623(+) | CCTCA(C/T)TCTAT | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs1002455041 | -- | 31,899,328(+) | GCACC(C/G)CACGT | intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs1003121795 | -- | 31,898,998(+) | ATTAA(C/G)AACGC | intron-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1003195376 | -- | 31,902,427(+) | TCTCG(A/G)CTGCG | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10403n54 | CNV | loss | 21841781 |
| dgv10404n54 | CNV | loss | 21841781 |
| dgv10463n54 | CNV | loss | 21841781 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv10822 | CNV | gain | 18304495 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv508399 | CNV | deletion | 20534489 |
| nsv509126 | CNV | insertion | 20534489 |
| nsv601960 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.56;
65.00% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ZBTB12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZBTB12
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB12 Gene
Disorders for ZBTB12 Gene
Relevant External Links for ZBTB12
No disorders were found for ZBTB12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB12 Gene
Publications for ZBTB12 Gene
- A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PMID: 21764829) Png E. … Seielstad M. (Hum. Mol. Genet. 2011) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4 64
- TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 2 3 64
Products for ZBTB12 Gene
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- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for ZBTB12
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- OriGene Purified Proteins for ZBTB12
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- ViGene Biosciences adenoviral particle packaged cDNA for ZBTB12 gene
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- Horizon Cell Lines for ZBTB12
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZBTB12
- VectorBuilder custom plasmid, inducible vectors for ZBTB12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZBTB12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ZBTB12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer