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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB12 Gene

protein-coding   GIFtS: 45
GCID: GC06M031868

Zinc Finger And BTB Domain Containing 12

(Previous name: chromosome 6 open reading frame 46)
(Previous symbol: C6orf46)
  2 related diseases
at
MalaCards
 

Aliases
for ZBTB12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Zinc Finger And BTB Domain Containing 121 2     Bat92
C6orf461 2 3     D6S59E2
G102 3     HLA-B-Associated Transcript 92
NG352 3     Zinc Finger And BTB Domain-Containing Protein 122
Chromosome 6 Open Reading Frame 461     Protein G103

External Ids:    HGNC: 190661   Entrez Gene: 2215272   Ensembl: ENSG000002043667   UniProtKB: Q9Y3303   

Export aliases for ZBTB12 gene to outside databases

Previous GC identifers: GC06M031972 GC06M031975 GC06M031653


Summaries
for ZBTB12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for ZBTB12 Gene: 
ZBTB12 (zinc finger and BTB domain containing 12) is a protein-coding gene. Diseases associated with ZBTB12 include hepatitis b, and hepatitis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZBTB34.

UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330
Function: May be involved in transcriptional regulation




Genomic Views
for ZBTB12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167247.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB12 gene promoter:
         AREB6   C/EBPbeta   AP-1   ATF-2   MyoD   c-Jun   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZBTB12 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.31

ZBTB12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB12 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031868:  view genomic region     (about GC identifiers)

Start:
 31,867,384 bp from pter      End:
 31,869,769 bp from pter
Size:
 2,386 bases      Orientation:
 minus strand

4 alternative locations:
Chr6-,NT_167247 3,247,277-3,249,652      Chr6-,NT_167245 3,152,976-3,155,351      Chr6-,NT_167248 3,161,186-3,163,563     
Chr6-,NT_113891.2 3,377,148-3,379,523     

Proteins
for ZBTB12 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 12  
Size: 459 amino acids; 49148 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B0UY00 Q5JQ98

Explore the universe of human proteins at neXtProt for ZBTB12: NX_Q9Y330

Explore proteomics data for ZBTB12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y330

    • ZBTB12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB12 Protein Expression
    REFSEQ proteins: NP_862825.1  
    ENSEMBL proteins: 
     ENSP00000364677  

    Human Recombinant Protein Products for ZBTB12: 
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    Novus Biologicals ZBTB12 Protein
    Novus Biologicals ZBTB12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZBTB12 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZBTB12 for ontologies           About GeneDecksing



    ZBTB12 Antibody Products: 
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    Protein Domains /
    Families
    for ZBTB12 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q9Y330

    ProtoNet protein and cluster: Q9Y330

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 4 C2H2-type zinc fingers


    ZBTB12 for domains           About GeneDecksing


    Function
    for ZBTB12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT12_HUMAN, Q9Y330
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB12 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB12:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB12 
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    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB12:
    hsa-miR-330-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB12 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ZBTB12
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB12


    Pathways & Interactions
    for ZBTB12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB12

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ZBTB12 (Q9Y3303 ENSP000003646774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=1 STRING: ENSP00000309845
    RAP1GAPENSP000003638974STRING: ENSP00000363897
    --Q7Z5S83I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZBTB12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZBTB12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB12 (ZBT12)

    Search CenterWatch for drugs/clinical trials and news about ZBTB12 / ZBT12

    Transcripts
    for ZBTB12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZBTB12 gene: 
    NM_181842.2  

    Unigene Cluster for ZBTB12:

    Zinc finger and BTB domain containing 12
    Hs.234027  [show with all ESTs]
    Unigene Representative Sequence: BC043609
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375527(uc003nyd.1)
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB12
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB12:
    hsa-miR-330-5p hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmid: ZBTB12 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZBTB12
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    Sirion Biotech Customized lentivirus for stable overexpression of ZBTB12 
                         Customized lentivirus expression plasmids for stable overexpression of ZBTB12 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for ZBTB12
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB12

    Additional mRNA sequence: BC043609.1 

    2 DOTS entries:

    DT.92031606  DT.75111599 

    4 AceView cDNA sequences:

    BM926596 BC043609 NM_181842 BF812094 

    GeneLoc Exon Structure


    Expression
    for ZBTB12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATGTGGA
    ZBTB12 Expression
    About this image


    See ZBTB12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB12

    SOURCE GeneReport for Unigene cluster: Hs.234027
        SABiosciences Custom PCR Arrays for ZBTB12
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB12

    Orthologs
    for ZBTB12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB12 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Zbtb121 , 5 zinc finger and BTB domain containing 121, 5 89.47(n)1
    97.39(a)1    		   17 (18.43 cM)5
    1937361  NM_198886.31  NP_942589.31 
     348794835 
    lizard
    (Anolis carolinensis)    		 Reptilia ZBTB126
    --
    		 Uncharacterized protein
    		 66(a)
    31(a)
    		 1 ↔ 1
    possible ortholog
    		 2(194374020-194379051)
    GL344259.1(9393-10830)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.108172 Xenopus laevis transcribed sequence with weak similarity to protein refNP_065975.1 (H.sapiens) bioref [Homo sapiens] less 74.42(n)    CA789158.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.145132 Transcribed sequence with weak similarity to protein refNP_065975.1 (H.sapiens) bioref [Homo sapiens] less 76.64(n)    BI839714.1 


    ENSEMBL Gene Tree for ZBTB12 (if available)
    TreeFam Gene Tree for ZBTB12 (if available)

    Paralogs
    for ZBTB12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB12 gene
    ZBTB342  ZBTB222  NACC12  ZBTB452  ZBTB62  ZBTB92  NACC22  ZBTB372  
    ZBTB262  ZBTB432  ZBTB202  
    2 SIMAP similar genes for ZBTB12 using alignment to 1 protein entry:     ZBT12_HUMAN:
    ZBTB26    ZBTB6

    ZBTB12 for paralogs           About GeneDecksing



    Genomic Variants
    for ZBTB12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    		Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for ZBTB12 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509126CNV Insertion20534489
    dgv6583n71CNV Loss21882294
    dgv6598n71CNV Loss21882294
    dgv6595n71CNV Loss21882294
    dgv6597n71CNV Loss21882294
    dgv6596n71CNV Loss21882294
    nsv884472CNV Loss21882294
    nsv508399CNV Loss20534489
    dgv6600n71CNV Loss21882294
    nsv884486CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB12
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB12

    Disorders / Diseases
    for ZBTB12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 2 diseases for ZBTB12:    About MalaCards
    hepatitis b    hepatitis


    ZBTB12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZBTB12
    Human Genome Epidemiology (HuGE) Navigator: ZBTB12 (2 documents)

    Export disorders for ZBTB12 gene to outside databases

    Publications
    for ZBTB12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB12 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZBTB12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PubMed id 21764829)1, 4 Png E....Seielstad M. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
    5. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)1, 3 Herberg J.A.... Trowsdale J. (1998)
    6. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PubMed id 23263863)1 Li J....Sleiman P.M. (2013)
    7. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    8. Genetic variations at loci involved in the immune res ponse are risk factors for hepatocellular carcinoma. (PubMed id 21105107)4 Clifford R.J....Buetow K.H. (2010)
    9. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PubMed id 18204098)4 Hom G....Behrens T.W. (2008)
    10. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.Y....Zeng R. (2007)

    External Searches for ZBTB12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZBTB12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221527 HGNC: 19066 AceView: ZBTB12 Ensembl:ENSG00000204366 euGenes: HUgn221527
    ECgene: ZBTB12 H-InvDB: ZBTB12

    Other Databases showing ZBTB12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZBTB12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB12 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ZBTB12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZBTB12 gene:
    Search GeneIP for patents involving ZBTB12

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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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