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Aliases for ZBTB12 Gene

Aliases for ZBTB12 Gene

  • Zinc Finger And BTB Domain Containing 12 2 3
  • C6orf46 3 4
  • NG35 3 4
  • G10 3 4
  • Chromosome 6 Open Reading Frame 46 2
  • HLA-B-Associated Transcript 9 3
  • Protein G10 4
  • D6S59E 3
  • Bat9 3

External Ids for ZBTB12 Gene

Previous HGNC Symbols for ZBTB12 Gene

  • C6orf46

Previous GeneCards Identifiers for ZBTB12 Gene

  • GC06M031972
  • GC06M031975
  • GC06M031868
  • GC06M031653

Summaries for ZBTB12 Gene

GeneCards Summary for ZBTB12 Gene

ZBTB12 (Zinc Finger And BTB Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is NACC2.

UniProtKB/Swiss-Prot for ZBTB12 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB12 Gene

Genomics for ZBTB12 Gene

Regulatory Elements for ZBTB12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBTB12 Gene

Chromosome:
6
Start:
31,899,204 bp from pter
End:
31,902,367 bp from pter
Size:
3,164 bases
Orientation:
Minus strand

Genomic View for ZBTB12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZBTB12 Gene

  • Protein details for ZBTB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y330-ZBT12_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 12
    Protein Accession:
    Q9Y330
    Secondary Accessions:
    • B0UY00
    • Q5JQ98

    Protein attributes for ZBTB12 Gene

    Size:
    459 amino acids
    Molecular mass:
    49148 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB12 Gene

Proteomics data for ZBTB12 Gene at MOPED

Post-translational modifications for ZBTB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZBTB12 Gene

Domains & Families for ZBTB12 Gene

Protein Domains for ZBTB12 Gene

Suggested Antigen Peptide Sequences for ZBTB12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y330

UniProtKB/Swiss-Prot:

ZBT12_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB12: view

Function for ZBTB12 Gene

Molecular function for ZBTB12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB12: view

Phenotypes for ZBTB12 Gene

GenomeRNAi human phenotypes for ZBTB12:
genes like me logo Genes that share phenotypes with ZBTB12: view

Animal Model Products

CRISPR Products

miRNA for ZBTB12 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB12 Gene

Localization for ZBTB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB12 Gene

Gene Ontology (GO) - Cellular Components for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB12: view

No data available for Subcellular locations from COMPARTMENTS for ZBTB12 Gene

Pathways & Interactions for ZBTB12 Gene

SuperPathways for ZBTB12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB12: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB12 Gene

Drugs & Compounds for ZBTB12 Gene

No Compound Related Data Available

Transcripts for ZBTB12 Gene

mRNA/cDNA for ZBTB12 Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB12 Gene

Zinc finger and BTB domain containing 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBTB12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB12 Gene

No ASD Table

Relevant External Links for ZBTB12 Gene

GeneLoc Exon Structure for
ZBTB12
ECgene alternative splicing isoforms for
ZBTB12

Expression for ZBTB12 Gene

mRNA expression in normal human tissues for ZBTB12 Gene

Protein differential expression in normal tissues from HIPED for ZBTB12 Gene

This gene is overexpressed in Breast (62.8) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB12 Gene



SOURCE GeneReport for Unigene cluster for ZBTB12 Gene Hs.234027

genes like me logo Genes that share expression patterns with ZBTB12: view

Protein tissue co-expression partners for ZBTB12 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB12 Gene

Orthologs for ZBTB12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBTB12 35
  • 92.08 (n)
  • 98.91 (a)
ZBTB12 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB12 35
  • 91.87 (n)
  • 98.47 (a)
ZBTB12 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb12 35
  • 89.47 (n)
  • 97.39 (a)
Zbtb12 16
Zbtb12 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBTB12 35
  • 99.35 (n)
  • 99.56 (a)
ZBTB12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb12 35
  • 89.98 (n)
  • 97.82 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB12 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB12 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17103 35
zbtb12 35
  • 58.73 (n)
  • 63.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10817 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14513 35
zbtb12.2 36
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6329 35
Species with no ortholog for ZBTB12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB12 Gene

ENSEMBL:
Gene Tree for ZBTB12 (if available)
TreeFam:
Gene Tree for ZBTB12 (if available)

Paralogs for ZBTB12 Gene

(2) SIMAP similar genes for ZBTB12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB12: view

Variants for ZBTB12 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBTB12 Gene

Variant ID Type Subtype PubMed ID
dgv6583n71 CNV Loss 21882294
nsv884472 CNV Loss 21882294
nsv508399 CNV Loss 20534489
nsv509126 CNV Insertion 20534489
dgv6595n71 CNV Loss 21882294
nsv884476 CNV Gain 21882294
dgv6596n71 CNV Loss 21882294
dgv6597n71 CNV Loss 21882294
dgv6598n71 CNV Loss 21882294
nsv884486 CNV Loss 21882294
dgv6599n71 CNV Loss 21882294
dgv6600n71 CNV Loss 21882294
dgv6601n71 CNV Loss 21882294
nsv10822 CNV Gain 18304495

Variation tolerance for ZBTB12 Gene

Residual Variation Intolerance Score: 23.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB12 Gene

HapMap Linkage Disequilibrium report
ZBTB12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ZBTB12 Gene

Disorders for ZBTB12 Gene

Relevant External Links for ZBTB12

Genetic Association Database (GAD)
ZBTB12
Human Genome Epidemiology (HuGE) Navigator
ZBTB12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB12
genes like me logo Genes that share disorders with ZBTB12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB12 Gene

Publications for ZBTB12 Gene

  1. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 2 67
  2. GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. (PMID: 24871463) Armstrong D.L. … Jacob C.O. (Genes Immun. 2014) 67
  3. GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PMID: 23263863) Li J. … Sleiman P.M. (Hum. Mol. Genet. 2013) 67
  4. Association of MHC class-III gene polymorphisms with ER-positive breast cancer in Chinese Han population. (PMID: 23079975) Pan Q. … Wang J.X. (Genet. Mol. Res. 2012) 67
  5. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67

Products for ZBTB12 Gene

Sources for ZBTB12 Gene

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