Aliases for ZBTB12 Gene
Aliases for ZBTB12 Gene
External Ids for ZBTB12 Gene
- HGNC: 19066
- Entrez Gene: 221527
- Ensembl: ENSG00000204366
- UniProtKB: Q9Y330
Previous HGNC Symbols for ZBTB12 Gene
- C6orf46
Previous GeneCards Identifiers for ZBTB12 Gene
- GC06M031972
- GC06M031975
- GC06M031868
- GC06M031653
Summaries for ZBTB12 Gene
GeneCards Summary for ZBTB12 Gene
ZBTB12 (Zinc Finger And BTB Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is ZBTB22.
UniProtKB/Swiss-Prot for ZBTB12 Gene
-
May be involved in transcriptional regulation.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB12 Gene
Genomics for ZBTB12 Gene
Regulatory Elements for ZBTB12 Gene
Enhancers for ZBTB12 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ZBTB12 on UCSC Golden Path with GeneCards custom track
Promoters for ZBTB12 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ZBTB12 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ZBTB12 gene promoter:
Regulatory Element Products
Genomic Location for ZBTB12 Gene
- Chromosome:
- 6
- Start:
- 31,899,204 bp from pter
- End:
- 31,902,367 bp from pter
- Size:
- 3,164 bases
- Orientation:
- Minus strand
Genomic View for ZBTB12 Gene
Genes around ZBTB12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by Ensembl
- 6p21.33 by Entrez Gene
- 6p21.31 by HGNC
ZBTB12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZBTB12 Gene
Proteins for ZBTB12 Gene
-
Protein details for ZBTB12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y330-ZBT12_HUMAN
- Recommended name:
- Zinc finger and BTB domain-containing protein 12
- Protein Accession:
- Q9Y330
- B0UY00
- Q5JQ98
Protein attributes for ZBTB12 Gene
- Size:
- 459 amino acids
- Molecular mass:
- 49148 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZBTB12 Gene
Post-translational modifications for ZBTB12 Gene
Other Protein References for ZBTB12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZBTB12
- Novus Biologicals Antibodies for ZBTB12
- Abcam antibodies for ZBTB12
- antibodies-online Antibodies for ZBTB12: See all 38
- Search GeneTex for Antibodies for ZBTB12
-
Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB12
Protein Products
-
OriGene Purified Proteins for ZBTB12
- Search Origene for MassSpec and Protein Over-expression Lysates for ZBTB12
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- Search GeneTex for Proteins for ZBTB12
- Abcam proteins for ZBTB12
Assay Products
No data available for DME Specific Peptides for ZBTB12 Gene
Domains & Families for ZBTB12 Gene
Gene Families for ZBTB12 Gene
Protein Domains for ZBTB12 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZBTB12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y330- Domain:
-
- Contains 1 BTB (POZ) domain.
- Similarity:
-
- Contains 4 C2H2-type zinc fingers.
Function for ZBTB12 Gene
Molecular function for ZBTB12 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes for ZBTB12 Gene
- GenomeRNAi human phenotypes for ZBTB12:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
- Search ViGene Biosciences for ZBTB12
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB12
- GenScript: Design CRISPR guide RNA sequences for ZBTB12
miRNA for ZBTB12 Gene
- miRTarBase miRNAs that target ZBTB12
Targeted motifs for ZBTB12 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB12
- Consensus sequence: NGNTCTAGAACCNGV Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341
miRNA Products
- Search ViGene Biosciences for ZBTB12
Clone Products
- OriGene clones in human for ZBTB12
- OriGene ORF clones in human,mouse,rat for ZBTB12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZBTB12 Gene
Localization for ZBTB12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZBTB12 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
No data available for Gene Ontology (GO) - Cellular Components for ZBTB12 Gene
Pathways & Interactions for ZBTB12 Gene
More details on SuperPathways for ZBTB12
No Data Available
Interacting Proteins for ZBTB12 Gene
No data available for Pathways by source and SIGNOR curated interactions for ZBTB12 Gene
Transcripts for ZBTB12 Gene
mRNA/cDNA for ZBTB12 Gene
- (6) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZBTB12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB12
- GenScript: Design CRISPR guide RNA sequences for ZBTB12
miRNA Products
- Search ViGene Biosciences for ZBTB12
Clone Products
- OriGene clones in human for ZBTB12
- OriGene ORF clones in human,mouse,rat for ZBTB12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for ZBTB12 Gene
This gene is overexpressed in Breast (62.8) and Peripheral blood mononuclear cells (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB12 Gene
SOURCE GeneReport for Unigene cluster for ZBTB12 Gene Hs.234027
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for ZBTB12
-
OriGene qPCR primer pairs and template standards for ZBTB12
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB12 Gene
Orthologs for ZBTB12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ZBTB12 35 |
|
||
| ZBTB12 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ZBTB12 35 |
|
||
| ZBTB12 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Zbtb12 35 |
|
||
| Zbtb12 16 |
|
||||
| Zbtb12 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ZBTB12 35 |
|
||
| ZBTB12 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Zbtb12 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZBTB12 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ZBTB12 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.17103 35 |
|
||
| zbtb12 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10817 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.14513 35 |
|
||
| zbtb12.2 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6329 35 |
|
- Species with no ortholog for ZBTB12:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZBTB12 Gene
Paralogs for ZBTB12 Gene
(2) SIMAP similar genes for ZBTB12 Gene using alignment to 1 proteins:
Variants for ZBTB12 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6583n71 | CNV | Loss | 21882294 |
| nsv884472 | CNV | Loss | 21882294 |
| nsv508399 | CNV | Loss | 20534489 |
| nsv509126 | CNV | Insertion | 20534489 |
| dgv6595n71 | CNV | Loss | 21882294 |
| nsv884476 | CNV | Gain | 21882294 |
| dgv6596n71 | CNV | Loss | 21882294 |
| dgv6597n71 | CNV | Loss | 21882294 |
| dgv6598n71 | CNV | Loss | 21882294 |
| nsv884486 | CNV | Loss | 21882294 |
| dgv6599n71 | CNV | Loss | 21882294 |
| dgv6600n71 | CNV | Loss | 21882294 |
| dgv6601n71 | CNV | Loss | 21882294 |
| nsv10822 | CNV | Gain | 18304495 |
Residual Variation Intolerance Score:
23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.56;
65.00% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ZBTB12 Gene
Disorders for ZBTB12 Gene
Relevant External Links for ZBTB12
No disorders were found for ZBTB12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB12 Gene
Publications for ZBTB12 Gene
- A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PMID: 21764829) Png E. … Seielstad M. (Hum. Mol. Genet. 2011) 3 48 67
- TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 2 3
- GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. (PMID: 24871463) Armstrong D.L. … Jacob C.O. (Genes Immun. 2014) 3
- GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. (PMID: 23263863) Li J. … Sleiman P.M. (Hum. Mol. Genet. 2013) 3
- The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3
Products for ZBTB12 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for ZBTB12
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- OriGene qPCR primer pairs for ZBTB12
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- OriGene clones in human for ZBTB12
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- Novus Biologicals
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- Abcam antibodies for ZBTB12
- Abcam proteins for ZBTB12
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for ZBTB12 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ZBTB12
- Search Santa Cruz Biotechnology (SCBT) for ZBTB12 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB12
Sources for ZBTB12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
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- (59) IMGT
- (60) Leiden
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- (62) miRBase
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- (64) Nature
- (65) NCBI
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- (67) PubMed
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- (69) Salk
- (70) TGDB
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- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
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- (107) COMPARTMENTS
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- (111) Addgene
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- (113) antibodies-online
- (114) CYP
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- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon