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Aliases for ZBTB12 Gene

Aliases for ZBTB12 Gene

  • Zinc Finger And BTB Domain Containing 12 2 3 5
  • C6orf46 3 4
  • NG35 3 4
  • G10 3 4
  • Zinc Finger And BTB Domain-Containing Protein 12 3
  • Chromosome 6 Open Reading Frame 46 2
  • HLA-B-Associated Transcript 9 3
  • Protein G10 4
  • D6S59E 3
  • Bat9 3

External Ids for ZBTB12 Gene

Previous HGNC Symbols for ZBTB12 Gene

  • C6orf46

Previous GeneCards Identifiers for ZBTB12 Gene

  • GC06M031972
  • GC06M031975
  • GC06M031868
  • GC06M031653

Summaries for ZBTB12 Gene

GeneCards Summary for ZBTB12 Gene

ZBTB12 (Zinc Finger And BTB Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is ZBTB26.

UniProtKB/Swiss-Prot for ZBTB12 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZBTB12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB12 Gene

Genomics for ZBTB12 Gene

Regulatory Elements for ZBTB12 Gene

Enhancers for ZBTB12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H031774 1.7 Ensembl ENCODE dbSUPER 38.8 +125.6 125561 3 MLX DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D GLIS1 NBN NR2C1 GTF2H4 PPT2 EGFL8 DXO ZBTB12 LY6G5B PRRC2A PRRT1 NFKBIL1 LSM2
GH06H031619 1.4 ENCODE dbSUPER 22.1 +281.1 281140 4 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 LSM2 ATF6B GTF2H4 LY6G5B MDC1 PPT2 DDX39B EGFL8 NFKBIL1 DXO
GH06H030907 1.2 ENCODE 19.9 +993.9 993910 2 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A MEF2D MDC1 GTF2H4 TRIM39 LY6G5B LSM2 DDX39B HCG18 PPP1R10 ENSG00000233892 DHX16
GH06H031269 1.6 FANTOM5 ENCODE dbSUPER 11.9 +630.9 630906 4 HDGF PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF2 YY1 ZNF121 GLIS2 HLA-C PSORS1C3 PPT2 TNXB LSM2 PSORS1C2 HCG18 HCG27 ENSG00000229836 TCF19
GH06H032583 1.5 Ensembl ENCODE dbSUPER 10.8 -682.9 -682936 3 GLI4 ZNF2 GLIS2 KLF7 SP3 YY2 TSHZ1 ZNF518A ZNF658 ZSCAN16 HLA-DRB1 HLA-DRB6 HLA-DQA2 HLA-DRB5 BRD2 LSM2 RXRB HLA-DQB1-AS1 PPT2 TNXB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB12 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195616 267 1401 HDGF ATF1 SIN3A DMAP1 ZNF2 ETS1 ZNF766 GLIS2 ELK1 ZNF143

Genomic Location for ZBTB12 Gene

Chromosome:
6
Start:
31,899,204 bp from pter
End:
31,902,367 bp from pter
Size:
3,164 bases
Orientation:
Minus strand

Genomic View for ZBTB12 Gene

Genes around ZBTB12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ZBTB12 Gene

  • Protein details for ZBTB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y330-ZBT12_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 12
    Protein Accession:
    Q9Y330
    Secondary Accessions:
    • B0UY00
    • Q5JQ98

    Protein attributes for ZBTB12 Gene

    Size:
    459 amino acids
    Molecular mass:
    49148 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZBTB12 Gene

Post-translational modifications for ZBTB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBTB12 Gene

Domains & Families for ZBTB12 Gene

Gene Families for ZBTB12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZBTB12 Gene

Suggested Antigen Peptide Sequences for ZBTB12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBTB12: view

No data available for UniProtKB/Swiss-Prot for ZBTB12 Gene

Function for ZBTB12 Gene

Molecular function for ZBTB12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZBTB12 Gene

Gene Ontology (GO) - Molecular Function for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB12: view
genes like me logo Genes that share phenotypes with ZBTB12: view

Animal Model Products

CRISPR Products

miRNA for ZBTB12 Gene

Targeted motifs for ZBTB12 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB12
  • Consensus sequence: NGNTCTAGAACCNGV Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZBTB12 Gene

Localization for ZBTB12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB12 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZBTB12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB12 Gene

Pathways & Interactions for ZBTB12 Gene

SuperPathways for ZBTB12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB12: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB12 Gene

Drugs & Compounds for ZBTB12 Gene

No Compound Related Data Available

Transcripts for ZBTB12 Gene

mRNA/cDNA for ZBTB12 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBTB12 Gene

Zinc finger and BTB domain containing 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZBTB12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB12 Gene

No ASD Table

Relevant External Links for ZBTB12 Gene

GeneLoc Exon Structure for
ZBTB12
ECgene alternative splicing isoforms for
ZBTB12

Expression for ZBTB12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBTB12 Gene

Protein differential expression in normal tissues from HIPED for ZBTB12 Gene

This gene is overexpressed in Breast (62.8) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB12 Gene



Protein tissue co-expression partners for ZBTB12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBTB12 Gene:

ZBTB12

SOURCE GeneReport for Unigene cluster for ZBTB12 Gene:

Hs.234027

Evidence on tissue expression from TISSUES for ZBTB12 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with ZBTB12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB12 Gene

Orthologs for ZBTB12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB12 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia ZBTB12 33 34
  • 92.08 (n)
dog
(Canis familiaris)
Mammalia ZBTB12 33 34
  • 91.87 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb12 33
  • 89.98 (n)
mouse
(Mus musculus)
Mammalia Zbtb12 33 16 34
  • 89.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB12 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZBTB12 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb12 33
  • 58.73 (n)
Str.17103 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10817 33
zebrafish
(Danio rerio)
Actinopterygii zbtb12.2 34
  • 36 (a)
OneToOne
Dr.14513 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6329 33
Species where no ortholog for ZBTB12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB12 Gene

ENSEMBL:
Gene Tree for ZBTB12 (if available)
TreeFam:
Gene Tree for ZBTB12 (if available)

Paralogs for ZBTB12 Gene

(2) SIMAP similar genes for ZBTB12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBTB12: view

Variants for ZBTB12 Gene

Sequence variations from dbSNP and Humsavar for ZBTB12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000900895 -- 31,899,814(+) GCCTC(A/C)CACTC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1002382850 -- 31,899,623(+) CCTCA(C/T)TCTAT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1002455041 -- 31,899,328(+) GCACC(C/G)CACGT intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1003121795 -- 31,898,998(+) ATTAA(C/G)AACGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003195376 -- 31,902,427(+) TCTCG(A/G)CTGCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBTB12 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv10822 CNV gain 18304495
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv508399 CNV deletion 20534489
nsv509126 CNV insertion 20534489
nsv601960 CNV loss 21841781

Variation tolerance for ZBTB12 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB12 Gene

Disorders for ZBTB12 Gene

Relevant External Links for ZBTB12

Genetic Association Database (GAD)
ZBTB12
Human Genome Epidemiology (HuGE) Navigator
ZBTB12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB12

No disorders were found for ZBTB12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB12 Gene

Publications for ZBTB12 Gene

  1. A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PMID: 21764829) Png E … Seielstad M (Human molecular genetics 2011) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T … Hood L (Genome research 2003) 3 4 60
  5. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg JA … Trowsdale J (Journal of molecular biology 1998) 2 3 60

Products for ZBTB12 Gene

Sources for ZBTB12 Gene

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