Aliases for ZBTB12 Gene
Aliases for ZBTB12 Gene
External Ids for ZBTB12 Gene
- HGNC: 19066
- Entrez Gene: 221527
- Ensembl: ENSG00000204366
- UniProtKB: Q9Y330
Previous HGNC Symbols for ZBTB12 Gene
- C6orf46
Previous GeneCards Identifiers for ZBTB12 Gene
- GC06M031972
- GC06M031975
- GC06M031868
- GC06M031653
Summaries for ZBTB12 Gene
GeneCards Summary for ZBTB12 Gene
ZBTB12 (Zinc Finger And BTB Domain Containing 12) is a Protein Coding gene. An important paralog of this gene is ZBTB26.
UniProtKB/Swiss-Prot for ZBTB12 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZBTB12 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB12 Gene
Genomics for ZBTB12 Gene
GeneHancer (GH) Regulatory Elements for ZBTB12 Gene
Promoters and enhancers for ZBTB12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZBTB12 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZBTB12 Gene
Genomic Locations for ZBTB12 Gene
- chr6:31,899,204-31,902,367
- (GRCh38/hg38)
- Size:
- 3,164 bases
- Orientation:
- Minus strand
- chr6:31,867,384-31,869,769
- (GRCh37/hg19)
Genomic View for ZBTB12 Gene
Genes around ZBTB12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by Ensembl
- 6p21.33 by Entrez Gene
- 6p21.33 by HGNC
ZBTB12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZBTB12 Gene
Proteins for ZBTB12 Gene
-
Protein details for ZBTB12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y330-ZBT12_HUMAN
- Recommended name:
- Zinc finger and BTB domain-containing protein 12
- Protein Accession:
- Q9Y330
- B0UY00
- Q5JQ98
Protein attributes for ZBTB12 Gene
- Size:
- 459 amino acids
- Molecular mass:
- 49148 Da
- Quaternary structure:
- No Data Available
Protein Expression for ZBTB12 Gene
Post-translational modifications for ZBTB12 Gene
No Post-translational modifications
Other Protein References for ZBTB12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZBTB12
- Novus Biologicals Antibodies for ZBTB12
-
Abcam antibodies for ZBTB12
- Invitrogen Antibodies for ZBTB12
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Protein Products
-
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- antibodies-online: Search results for 2 available ZBTB12 Proteins ranked by validation data
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-
Quality Products:
- Search GeneTex for Proteins for ZBTB12
-
Abcam proteins for ZBTB12
Assay Products
No data available for DME Specific Peptides for ZBTB12 Gene
Domains & Families for ZBTB12 Gene
Gene Families for ZBTB12 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZBTB12 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZBTB12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ZBTB12 Gene
Function for ZBTB12 Gene
Molecular function for ZBTB12 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZBTB12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZBTB12 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ZBTB12 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for ZBTB12
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB12
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miRNA for ZBTB12 Gene
- miRTarBase miRNAs that target ZBTB12
Targeted motifs for ZBTB12 Gene
HOMER Transcription Factor Regulatory Elements motif ZBTB12
- Consensus sequence: NGNTCTAGAACCNGV Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341
miRNA Products
- Search ViGene Biosciences for ZBTB12
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZBTB12 gene related products
- orf clones - Search results for available ZBTB12 gene related products
- Applied Biological Materials Clones for ZBTB12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZBTB12
-
ViGene Biosciences adenoviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ZBTB12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZBTB12 Gene
Localization for ZBTB12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZBTB12 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZBTB12 Gene
Pathways & Interactions for ZBTB12 Gene
No Data Available
Interacting Proteins for ZBTB12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZBTB12 Gene
Transcripts for ZBTB12 Gene
mRNA/cDNA for ZBTB12 Gene
- (2) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZBTB12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZBTB12
- genomics-online: gRNA clones - Search results for available ZBTB12 gene related products
- Applied Biological Materials CRISPR for ZBTB12
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZBTB12
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miRNA Products
- Search ViGene Biosciences for ZBTB12
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZBTB12
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- genomics-online: shRNA clones - Search results for available ZBTB12 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ZBTB12 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZBTB12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ZBTB12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZBTB12 gene related products
- orf clones - Search results for available ZBTB12 gene related products
- Applied Biological Materials Clones for ZBTB12
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ZBTB12 Gene
This gene is overexpressed in Breast (62.8) and Peripheral blood mononuclear cells (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB12 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZBTB12 Gene:
ZBTB12SOURCE GeneReport for Unigene cluster for ZBTB12 Gene:
Hs.234027Evidence on tissue expression from TISSUES for ZBTB12 Gene
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for ZBTB12
-
OriGene qPCR primer pairs for ZBTB12
- genomics-online: primer clones - Search results for available ZBTB12 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBTB12 Gene
Orthologs for ZBTB12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZBTB12 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZBTB12 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZBTB12 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Zbtb12 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zbtb12 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ZBTB12 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | ZBTB12 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | zbtb12 33 |
|
||
| Str.17103 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10817 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zbtb12.2 34 |
|
OneToOne | |
| Dr.14513 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6329 33 |
|
- Species where no ortholog for ZBTB12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZBTB12 Gene
Variants for ZBTB12 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000900895 | -- | 31,899,814(-) | C/A | 3_prime_UTR_variant | |
| rs1002382850 | -- | 31,899,623(-) | T/C | 3_prime_UTR_variant | |
| rs1002455041 | -- | 31,899,328(-) | C/G | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
| rs1003121795 | -- | 31,898,998(-) | G/C | downstream_transcript_variant | |
| rs1003195376 | -- | 31,902,427(-) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10403n54 | CNV | loss | 21841781 |
| dgv10404n54 | CNV | loss | 21841781 |
| dgv10463n54 | CNV | loss | 21841781 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv10822 | CNV | gain | 18304495 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv508399 | CNV | deletion | 20534489 |
| nsv509126 | CNV | insertion | 20534489 |
| nsv601960 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.56;
65.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZBTB12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ZBTB12
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB12 Gene
Disorders for ZBTB12 Gene
Additional Disease Information for ZBTB12
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ZBTB12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB12 Gene
Publications for ZBTB12 Gene
- A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PMID: 21764829) Png E … Seielstad M (Human molecular genetics 2011) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T … Hood L (Genome research 2003) 3 4 58
- TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg JA … Trowsdale J (Journal of molecular biology 1998) 2 3 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 46 available ZBTB12 Antibodies ranked by validation data
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Sources for ZBTB12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew