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ZBTB12 Gene

protein-coding   GIFtS: 44

GC06M031975
zinc finger and BTB domain containing 12
(Previous name: chromosome 6 open reading frame 46 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C6orf46)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
Bat9 2
C6orf46 2, 3
D6S59E 1, 2
Em:AF134726.1 1
G10 1, 2, 3
NG35 1, 2, 3
Descriptions
HLA-B-associated transcript 9 2
Protein G10 3
chromosome 6 open reading frame 46 1
zinc finger and BTB domain containing 12 2
External Ids
HGNC: 190661
Entrez Gene: 2215272
UniProtKB: Q9Y3303
Ensembl: ENSG000002043667
Search outside databases for aliases for ZBTB12 gene

Previous GC identifer: GC06M031972

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330
Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB12 gene  

Entrez Gene cytogenetic band: 6p21.32   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.31

ZBTB12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031975:     (about GC identifiers)

Start:
31,975,373 bp from pter
End:
31,977,748 bp from pter
Size:
2,376 bases
Orientation:
minus strand

2 alternative locations:
Chr6-,c6_QBL 32,000,632-32,003,019      Chr6-,c6_COX 32,002,198-32,004,573     
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  NT_113891.1  NT_113895.1  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 12  
Size: 459 amino acids; 49148 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5JQ98

REFSEQ proteins: NP_862825.1  

ENSEMBL proteins: 
ENSP00000364677 


Human Recombinant Proteins 
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Browse Human Recombinant Proteins at Sigma-Aldrich  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ZBTB12)
Human Recombinant Proteins from Abnova (ZBTB12)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IEA--
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Antibodies for ZBTB12: 
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Sigma-Aldrich Antibodies for ZBTB12
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Antibodies from Abcam (ZBTB12), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ZBTB12)
Novus Biologicals Antibodies for ZBTB12

Assays for ZBTB12: 
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Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR000210 BTB/POZ-like
 IPR015880 Znf_C2H2-like
 IPR011333 BTB/POZ_fold
 IPR013069 BTB_POZ
 IPR007087 Znf_C2H2


   GeneDecks  ZBTB12 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9Y330

ProtoNet protein and cluster: Q9Y330

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 4 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB12)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBTB12)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181842

              Applied Biosystems Silencer® siRNAs for ZBTB12

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB12  
                     Sigma-Aldrich shRNA for ZBTB12  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ZBTB12
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181842
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_181842
                                 untagged cDNA clone in CMV expression vector: NM_181842 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_181842

UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330
Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0005515 protein binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for  ZBTB12  (Your Favorite Gene powered by Ingenuity) 
 Caveolar-mediated Endocytosis
 Protein Ubiquitination Pathway
 Dendritic Cell Maturation
 Virus Entry via Endocytic Pathways

   GeneDecks  ZBTB12 for the pathways selected above  
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  --

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB12

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBTB12)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBTB12)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181842

              Sigma-Aldrich siRNA and siRNA Panels for ZBTB12  
                     Sigma-Aldrich shRNA for ZBTB12  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_181842  

REFSEQ mRNAs for ZBTB12 gene: 

NM_181842.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_181842  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181842
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_181842
                                 untagged cDNA clone in CMV expression vector: NM_181842 

Additional cDNA sequence: BC043609.1 

2 DOTS entries:

DT.92031606  DT.75111599 

4 AceView cDNA sequences:

BM926596 BC043609 NM_181842 BF812094 

highest scoring ESTs for ZBTB12:

BC043609 BM926596 BF812094 NM_181842 CR747152 AW074205 CN265230 BM983706 CA313726 

Unigene Cluster for ZBTB12:

Zinc finger and BTB domain containing 12
Hs.234027  [show with all ESTs]
Unigene Representative Sequence: BC043609


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000375527  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB12 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB12

1 / 2

2 probe-sets matching ZBTB12 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

233843_at2 U133-B 3 1.00 0.42 -- -- -- -- -- -- --

233843_at2 U133Plus2 3 1.00 0.42 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TATATGTGGA

SOURCE GeneReport for Unigene cluster: Hs.234027
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ZBTB12 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZBTB121   -- zinc finger and BTB domain containing 12 91.87(n)
98.47(a)
481719  XM_538840.2  XP_538840.2 
chimpanzee
(Pan troglodytes)
ZBTB121   -- zinc finger and BTB domain containing 12 99.35(n)
99.56(a)
471969  XM_527347.2  XP_527347.2 
cow
(Bos taurus)
ZBTB121   -- zinc finger and BTB domain containing 12 92.08(n)
98.91(a)
539456  XM_587264.2  XP_587264.1 
mouse
(Mus musculus)
Zbtb121, 5 17 (18.87 cM)5
zinc finger and BTB domain containing 121, 5 89.4(n)1
97.17(a)1
1937361  NM_198886.21  NP_942589.21 
 AA1191755  AK1353055  (see all 7)
zebrafish
(Danio rerio)
Dr.145132   -- Transcribed sequence with weak similarity to protein more 76.64(n)  BI839714.1 
About this table        Species with no ortholog for ZBTB12

ENSEMBL Gene Tree for ZBTB12
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ZBTB12 gene
ZBTB62  ZBTB262  ENSG000001806102  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/21 NCBI SNPs in ZBTB12 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 19)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs5587021,2
A,C,F,H31978305(-) ACCAAC/TAGCTC 1 -- ng3111Minor allele frequency- T:0.05EU EA WA NS NA 1192
--
rs28444551,2
C,F,H31977652(-) TGCCGG/ACCCCG 1 -- ut51 ese34Minor allele frequency- A:0.25EU EA WA 418
rs92676651,2
C,F,H31978835(+) AGGAGC/TGTCTT 1 -- ng314Minor allele frequency- T:0.10EU EA WA 416
rs92676661,2
H31978977(+) TTTCCT/ATACAT 1 -- ng314Minor allele frequency- A:0.00EU EA WA 418
rs117559211,2
H31979733(+) CATTCC/ATAGGA 1 -- ng314Minor allele frequency- A:0.00EU EA WA 414
rs69392271,2
H31978852(+) TGGTGC/ACTTCC 1 -- ng31 trp32Minor allele frequency- A:0.00EA 178
--
rs132093961,2
--31976301(+) CAGTGA/CTGGGG 1 S/I mis1 ese30--------
--
rs43334421,2
--31978184(+) CTCGGC/GTGCGG 1 -- ng310--------
--
rs93940781,2
--31976917(+) GATGAC/TCTTGT 1 V/I mis1 ese30--------
--
rs132094031,2
--31976316(+) CGCTGA/CTCTGG 1 S/I mis1 ese30--------
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HapMap Linkage Disequilibrium images for ZBTB12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

7 PubMed articles for ZBTB12 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 221527 HGNC: 19066 AceView: ZBTB12 Ensembl:ENSG00000204366 euGenes: HUgn221527
ECgene: ZBTB12 H-InvDB: ZBTB12
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBTB12:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 "Your Favorite Gene" Pathwaysfeedback


  
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 Antibodies for ZBTB12

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