ZBTB12 Gene
protein-coding GIFtS: 44
GCID: GC06M031868
|
|
zinc finger and BTB domain containing 12(Previous name: chromosome 6 open reading frame 46 )
(Previous symbol: C6orf46)
| |
Aliases
for ZBTB12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 121 2 | | Chromosome 6 Open Reading Frame 461 | | C6orf461 2 3 | | Bat92 | | G101 2 3 | | HLA-B-Associated Transcript 92 | | NG351 2 3 | | Zinc Finger And BTB Domain-Containing Protein 122 | | D6S59E1 2 | | Protein G103 |
Export aliases for ZBTB12 gene to outside databasesPrevious GC identifers: GC06M031972 GC06M031975 GC06M031653 |
Summaries
for ZBTB12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167247.1 NT_167248.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB12 gene promoter:
AREB6 C/EBPbeta AP-1 ATF-2 MyoD c-Jun IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.31ZBTB12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031868: view genomic region
(about GC identifiers)
Start:
|
31,867,384 bp from pter |
End:
|
31,869,769 bp from pter |
Size:
|
2,386 bases |
Orientation:
|
minus strand |
4 alternative locations:
| Chr6-,ALT_REF_LOCI_3 31,849,569-31,862,992 | Chr6-,ALT_REF_LOCI_5 31,858,700-31,861,075 | Chr6-,ALT_REF_LOCI_2 31,854,934-31,896,507 | | Chr6-,ALT_REF_LOCI_6 31,857,779-31,895,747 |
|
Proteins
for ZBTB12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 12 Size: 459 amino acids; 49148 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: B0UY00 Q5JQ98Explore the universe of human proteins at neXtProt for ZBTB12: NX_Q9Y330
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y330
ZBTB12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_862825.1
ENSEMBL proteins: ENSP00000364677
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB12 for ontologies About GeneDecksing
ZBTB12 Antibody Products:
Assay Products for ZBTB12: |
Protein
Domains /
Families
for ZBTB12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB12 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9Y330ProtoNet protein and cluster: Q9Y330 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 4 C2H2-type zinc fingers |
Function
for ZBTB12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZBTB12 (NM_181842) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZBTB12 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZBTB12:
|
Pathways & Interactions
for ZBTB12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB12
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for ZBTB12 (Q9Y3303 ENSP000003646774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB12 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB12
Search CenterWatch for drugs/clinical trials and news about ZBTB12 / ZBT12
|
Transcripts
for ZBTB12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB12 gene: NM_181842.2 Unigene Cluster for ZBTB12: Zinc finger and BTB domain containing 12 Hs.234027 [show with all ESTs]Unigene Representative Sequence: BC0436091 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375527(uc003nyd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB12 (NM_181842) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB12 |
Additional cDNA sequence: BC043609.1 2 DOTS entries: DT.92031606 DT.75111599 4 AceView cDNA sequences: BM926596 NM_181842 BC043609 BF812094
GeneLoc Exon Structure
|
Expression
for ZBTB12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATGTGGA
About this image
See ZBTB12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB12
SOURCE GeneReport for Unigene cluster: Hs.234027
SABiosciences Custom PCR Arrays for ZBTB12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB12 |
Orthologs
for ZBTB12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB12 gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB126-- |
-- |
68(a)31(a) |
1 ↔ 1possible ortholog |
2(194374020-194379051) GL344259.1(9393-10830) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.108172 |
Xenopus laevis transcribed sequence with weak similarity more |
74.42(n) |
|
CA789158.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.145132 |
Transcribed sequence with weak similarity to protein more |
76.64(n) |
|
BI839714.1 |
ENSEMBL Gene Tree for ZBTB12 (if available)
TreeFam Gene Tree for ZBTB12 (if available) |
Paralogs
for ZBTB12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB12 gene
- ZBTB222 ZBTB342 NACC12 ZBTB62 ZBTB452 ZBTB92 NACC22 ZBTB262
- ZBTB372 ZBTB432 ZBTB202
2 SIMAP similar genes for ZBTB12 using alignment to 1 protein entry: ZBT12_HUMAN:ZBTB26 ZBTB6
ZBTB12 for paralogs About GeneDecksing
|
Genomic Variants
for ZBTB12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZBTB12
1 CNV: 31277 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB12 |
|
Disorders
/ Diseases
for ZBTB12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZBTB12 for disorders About MalaCards
ZBTB12 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZBTB12 (2 documents)
Export disorders for ZBTB12 gene to outside databases
|
Publications
for ZBTB12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBTB12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
- TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)1, 3 Herberg J.A.... Trowsdale J. (1998)
- The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
- A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PubMed id 21764829)1 Png E....Seielstad M. (2011)
- Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)2 Tang L.Y....Zeng R. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. (PubMed id 8939933)1 Peterson S.N.... White G.C. 2nd (1996)
|
External Searches for ZBTB12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB12 gene:
Search GeneIP for patents involving ZBTB12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZBTB12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB12 | | | OriGene Protein Over-expression Lysate for ZBTB12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZBTB12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZBTB12 | | OriGene Custom Protein Services for ZBTB12 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB12 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZBTB12 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZBTB12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB12 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZBTB12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB12 |
|
|
|
|
