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ZBTB12 Gene

protein-coding GIFtS: 44

GC06M031975

zinc finger and BTB domain containing 12
(Previous name: chromosome 6 open reading frame 46 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C6orf46)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Bat9 ^²
C6orf46 ^², ³
D6S59E ^¹, ²
Em:AF134726.1 ^¹
G10 ^¹, ², ³
NG35 ^¹, ², ³

Descriptions
HLA-B-associated transcript 9 ^²
Protein G10 ^³
chromosome 6 open reading frame 46 ^¹
zinc finger and BTB domain containing 12 ^²

External Ids
HGNC: 19066¹
Entrez Gene: 221527²
UniProtKB: Q9Y330³
Ensembl: ENSG00000204366⁷

Search outside databases for aliases for ZBTB12 gene

Previous GC identifer: GC06M031972

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB12 gene

Entrez Gene cytogenetic band: 6p21.32 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.31

ZBTB12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M031975: (about GC identifiers)

Start:	31,975,373 bp from pter
End:	31,977,748 bp from pter
Size:	2,376 bases
Orientation:	minus strand

2 alternative locations:

Chr6-,c6_QBL 32,000,632-32,003,019

Chr6-,c6_COX 32,002,198-32,004,573

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113895.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 12

Size: 459 amino acids; 49148 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q5JQ98

REFSEQ proteins: NP_862825.1

ENSEMBL proteins:

ENSP00000364677

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZBTB12)
	Human Recombinant Proteins from Abnova (ZBTB12)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for ZBTB12:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB12
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZBTB12), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBTB12)
	Novus Biologicals Antibodies for ZBTB12

Assays for ZBTB12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9Y330

ProtoNet protein and cluster: Q9Y330

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 4 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB12)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181842

Applied Biosystems Silencer® siRNAs for ZBTB12

Sigma-Aldrich siRNA and siRNA Panels for ZBTB12

Sigma-Aldrich shRNA for ZBTB12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBTB12
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_181842
Myc/DDK tagged cDNA clone in CMV expression vector: NM_181842
untagged cDNA clone in CMV expression vector: NM_181842

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_181842

UniProtKB/Swiss-Prot: ZBT12_HUMAN, Q9Y330

Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ZBTB12 (Your Favorite Gene powered by Ingenuity)

Caveolar-mediated Endocytosis
Protein Ubiquitination Pathway
Dendritic Cell Maturation
Virus Entry via Endocytic Pathways

GeneDecks ZBTB12 for the pathways selected above

About GeneDecksing

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB12

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB12)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181842

Sigma-Aldrich siRNA and siRNA Panels for ZBTB12

Sigma-Aldrich shRNA for ZBTB12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_181842

REFSEQ mRNAs for ZBTB12 gene:

NM_181842.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_181842

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181842
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_181842
                                 untagged cDNA clone in CMV expression vector: NM_181842

Additional cDNA sequence: BC043609.1

2 DOTS entries:

DT.92031606 DT.75111599

4 AceView cDNA sequences:

BM926596 BC043609 NM_181842 BF812094

highest scoring ESTs for ZBTB12:

BC043609 BM926596 BF812094 NM_181842 CR747152 AW074205 CN265230 BM983706 CA313726

Unigene Cluster for ZBTB12:

Zinc finger and BTB domain containing 12

Hs.234027 [show with all ESTs]

Unigene Representative Sequence: BC043609

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000375527

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB12

¹ / ²

2 probe-sets matching ZBTB12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
233843_at²	U133-B	3	1.00	0.42	--	--	--	--	--	--	--
233843_at²	U133Plus2	3	1.00	0.42	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATATGTGGA

SOURCE GeneReport for Unigene cluster: Hs.234027

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ZBTB12 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB12¹	--	zinc finger and BTB domain containing 12	91.87(n) 98.47(a)	481719 XM_538840.2 XP_538840.2
chimpanzee (Pan troglodytes)	ZBTB12¹	--	zinc finger and BTB domain containing 12	99.35(n) 99.56(a)	471969 XM_527347.2 XP_527347.2
cow (Bos taurus)	ZBTB12¹	--	zinc finger and BTB domain containing 12	92.08(n) 98.91(a)	539456 XM_587264.2 XP_587264.1
mouse (Mus musculus)	Zbtb12^{1, 5}	17 (18.87 cM)⁵	zinc finger and BTB domain containing 12^{1, 5}	89.4(n)¹ 97.17(a)¹	193736¹ NM_198886.2¹ NP_942589.2¹ AA119175⁵ AK135305⁵ (see all 7)
zebrafish (Danio rerio)	Dr.14513²	--	Transcribed sequence with weak similarity to protein more	76.64(n)	BI839714.1

About this table Species with no ortholog for ZBTB12

ENSEMBL Gene Tree for ZBTB12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBTB12 gene

ZBTB6² ZBTB26² ENSG00000180610²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in ZBTB12 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 19)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs558702^1,2	A,C,F,H	31978305(-)	`ACCAAC/TAGCTC`	1	--	ng3¹		11		EU EA WA NS NA	1192
--	rs2844455^1,2	C,F,H	31977652(-)	`TGCCGG/ACCCCG`	1	--	ut5¹ ese³		4		EU EA WA	418
	rs9267665^1,2	C,F,H	31978835(+)	`AGGAGC/TGTCTT`	1	--	ng3¹		4		EU EA WA	416
	rs9267666^1,2	H	31978977(+)	`TTTCCT/ATACAT`	1	--	ng3¹		4		EU EA WA	418
	rs11755921^1,2	H	31979733(+)	`CATTCC/ATAGGA`	1	--	ng3¹		4		EU EA WA	414
	rs6939227^1,2	H	31978852(+)	`TGGTGC/ACTTCC`	1	--	ng3¹ trp³		2		EA	178
--	rs13209396^1,2	--	31976301(+)	`CAGTGA/CTGGGG`	1	S/I	mis¹ ese³		0	--	--	--	--
--	rs4333442^1,2	--	31978184(+)	`CTCGGC/GTGCGG`	1	--	ng3¹		0	--	--	--	--
--	rs9394078^1,2	--	31976917(+)	`GATGAC/TCTTGT`	1	V/I	mis¹ ese³		0	--	--	--	--
--	rs13209403^1,2	--	31976316(+)	`CGCTGA/CTCTGG`	1	S/I	mis¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ZBTB12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for ZBTB12 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)^{3, 4} Xie T.... Hood L. (2003)
TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)^{2, 3} Herberg J.A.... Trowsdale J. (1998)
Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. (PubMed id 17693683)⁴ Tang L.Y....Zeng R. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. (PubMed id 8939933)³ Peterson S.N.... White G.C. 2nd (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 221527	HGNC: 19066	AceView: ZBTB12	Ensembl:ENSG00000204366	euGenes: HUgn221527
ECgene: ZBTB12	H-InvDB: ZBTB12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBTB12
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB12		Antibodies for ZBTB12
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBTB12		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBTB12)
	Antibodies (ZBTB12)
	Chimera RNAi (ZBTB12)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (ZBTB12)

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ZBTB12 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for ZBTB12

Summaries
for ZBTB12

Genomic Location
for ZBTB12

Proteins
for ZBTB12

Protein Domains/
Families
for ZBTB12

Gene Function
for ZBTB12

Pathways & Interactions
for ZBTB12

Drugs & Compounds
for ZBTB12

Transcripts
for ZBTB12

Expression
for ZBTB12

Orthologs
for ZBTB12

Paralogs
for ZBTB12

SNPs/Variants
for ZBTB12

Disorders & Mutations
for ZBTB12

Medical News
for ZBTB12

Publications
for ZBTB12

Search for ZBTB12

Genome Databases showing ZBTB12

Other Databases showing ZBTB12

Specialized Databases showing ZBTB12

Licensable Technologies
for ZBTB12

Services
for ZBTB12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB12 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor ZBTB12

Summariesfor ZBTB12

Genomic Locationfor ZBTB12

Proteinsfor ZBTB12

Protein Domains/Familiesfor ZBTB12

Gene Functionfor ZBTB12

Pathways & Interactionsfor ZBTB12

Drugs & Compoundsfor ZBTB12

Transcriptsfor ZBTB12

Expression for ZBTB12

Orthologsfor ZBTB12

Paralogsfor ZBTB12

SNPs/Variantsfor ZBTB12

Disorders & Mutationsfor ZBTB12

Medical Newsfor ZBTB12

Publicationsfor ZBTB12

Search for ZBTB12

Genome Databases showing ZBTB12

Other Databases showing ZBTB12

Specialized Databases showing ZBTB12

Licensable Technologiesfor ZBTB12

Servicesfor ZBTB12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB12

Summaries
for ZBTB12

Genomic Location
for ZBTB12

Proteins
for ZBTB12

Protein Domains/
Families
for ZBTB12

Gene Function
for ZBTB12

Pathways & Interactions
for ZBTB12

Drugs & Compounds
for ZBTB12

Transcripts
for ZBTB12

Expression
for ZBTB12

Orthologs
for ZBTB12

Paralogs
for ZBTB12

SNPs/Variants
for ZBTB12

Disorders & Mutations
for ZBTB12

Medical News
for ZBTB12

Publications
for ZBTB12

Licensable Technologies
for ZBTB12

Services
for ZBTB12