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ZBTB11 Gene

protein-coding GIFtS: 49

GC03M102850

zinc finger and BTB domain containing 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ13426 ^²
MGC133303 ^²
ZNF-U69274 ^¹, ²

Descriptions
zinc finger and BTB domain containing 11 ^²
zinc finger protein ZNF-U69274 ^²

External Ids
HGNC: 16740¹
Entrez Gene: 27107²
UniProtKB: O95625³
Ensembl: ENSG00000066422⁷

Search outside databases for aliases for ZBTB11 gene

Previous GC identifer: GC03M102690

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBTB11 gene

Entrez Gene cytogenetic band: 3q12.3 Ensembl cytogenetic band: 3q12.3 HGNC cytogenetic band: 3q12.3

ZBTB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M102850: (about GC identifiers)

Start:	102,850,978 bp from pter
End:	102,878,607 bp from pter
Size:	27,630 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625 (See protein sequence)

Recommended Name: Zinc finger and BTB domain-containing protein 11

Size: 1053 amino acids; 119384 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q2NKP9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055230.2

ENSEMBL proteins:

ENSP00000326200

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (zbtb11)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for ZBTB11:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBTB11
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (zbtb11), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZBTB11

Assays for ZBTB11:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O95625

ProtoNet protein and cluster: O95625

1 Blocks protein family: IPB000210 BTB/POZ domain

UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 12 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB11)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014415

Applied Biosystems Silencer® siRNAs for ZBTB11

Sigma-Aldrich siRNA and siRNA Panels for ZBTB11

Sigma-Aldrich shRNA for ZBTB11

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014415
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014415
untagged cDNA clone in CMV expression vector: NM_014415

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014415

UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625

Function: May be involved in transcriptional regulation

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Interacting proteins for ZBTB11 (O95625² ENSP00000326200³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD7	O15105²	MINT-61818
LRRC28	ENSP00000304923³	STRING (score=.712)
BTBD11	ENSP00000280758³	STRING (score=.706)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBTB11

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBTB11)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBTB11)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014415

Sigma-Aldrich siRNA and siRNA Panels for ZBTB11

Sigma-Aldrich shRNA for ZBTB11

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014415

REFSEQ mRNAs for ZBTB11 gene:

NM_014415.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014415

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014415
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014415
                                 untagged cDNA clone in CMV expression vector: NM_014415

Additional cDNA sequence:

AB208862.1 AK023488.1 AK312859.1 BC029342.1 BC111700.1 U69274.1

6 DOTS entries:

DT.95315652 DT.308117 DT.91650245 DT.100000676 DT.86846301 DT.99928948

24/112 AceView cDNA sequences (see all 112 ):

BM839526 BU189236 BM463877 BU174971 AW514881 AW272168 AI571122 AI375204

AI298175 CB215880 AA361624 BC028062 BX483910 BP362007 N51926 CB161435

AK023488 BQ022066 Z30284 AI636025 CR598311 CB161533 CA389273 AI522100

highest scoring ESTs for ZBTB11:

U69274 AV703490 AV757084 BP218247 BP229368 BP229677 BP231182 BP278113 BP311254 BP314644

Unigene Cluster for ZBTB11:

Zinc finger and BTB domain containing 11

Hs.655286 [show with all ESTs]

Unigene Representative Sequence: NM_014415

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000312938

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBTB11 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB11

¹ / ² / ³

4 probe-sets matching ZBTB11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39977_at²^{, 3}	U95-A	1	1.00	1.00	0.13	1.15	U69274	1.00	0.80	0.91	1
46967_at²^{, 3}	U95-B	1	0.31	1.00	0.90	0.86	AI972469	0.60	0.83	0.73	1
204847_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014415	0.60	0.83	0.73	1
204847_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.655286
Expression variation in blood from EXPOLDB for ZBTB11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBTB11 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBTB11¹	--	zinc finger and BTB domain containing 11	91.33(n) 92.97(a)	487956 XM_545078.2 XP_545078.2
chimpanzee (Pan troglodytes)	ZBTB11¹	--	zinc finger and BTB domain containing 11	99.65(n) 99.72(a)	460560 XM_516629.2 XP_516629.2
cow (Bos taurus)	ZBTB11¹	--	zinc finger and BTB domain containing 11	91.21(n) 92.48(a)	538545 XM_581040.3 XP_581040.3
rat (Rattus norvegicus)	Zbtb11¹	--	zinc finger and BTB domain containing 11	85.8(n) 89.45(a)	304010 XM_221562.4 XP_221562.3
mouse (Mus musculus)	Zbtb11^{1, 5}	16⁵	zinc finger and BTB domain containing 11^{1, 5}	87.05(n)¹ 89.43(a)¹	271377¹ XM_001481121.1¹ XP_001481171.1¹ AK033794⁵ AK048360⁵ (see all 6)

About this table Species with no ortholog for ZBTB11

ENSEMBL Gene Tree for ZBTB11

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/155 NCBI SNPs in ZBTB11 are shown (see all 155 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 39)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3806654^1,2	A,C,F,H	102879219(-)	`AATAAC/GATTGA`	1	--	ng3¹ tfbs³		11		EA MN EU WA NA	2624
	rs3806653^1,2	A,C,F,H	102879662(-)	`AGCCTA/GCTGTA`	1	--	ng3¹		4		EU EA WA	412
	rs3749323^1,2	C,F,H	102878319(-)	`TGCGCG/AGCGGG`	1	S/G	mis¹ ese³		9		EA EU WA	2330
--	rs1056579^1,2	A,C,F	102880567(-)	`AGAAGA/CAGCTA`	1	--	ng3¹ tfbs³		4		MN NA	326
	rs33957144^1,2	C,F	102867072(+)	`TTGTGG/TTTCCC`	1	T/N	mis¹		2		NA	162
--	rs3864012^1,2	A,C	102880313(+)	`ttaaaC/Tattta`	1	--	ng3¹		0	--	--	--	--
	rs9811237^1,2	C	102866976(+)	`GCTGTC/TGTCCT`	1	R/Q	mis¹ ese³		1		NA	74
--	rs16844121^1,2	F	102878796(-)	`TCCAAA/CATGTC`	1	--	ng3¹		2		MN EA	356
	rs3806652^1,2	C	102879777(-)	`GTCCCC/TGCACC`	1	--	ng3¹		0	--	--	--	--
	rs34474055^1,2	F	102866111(-)	`ATGCAC/TAAACT`	1	H/H	syn¹		1		NA	68

About this table

HapMap Linkage Disequilibrium images for ZBTB11 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for ZBTB11 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)³ Colland F....Gauthier J.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 27107	HGNC: 16740	AceView: ZBTB11	Ensembl:ENSG00000066422	euGenes: HUgn27107
ECgene: ZBTB11	H-InvDB: ZBTB11

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZBTB11
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBTB11:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBTB11-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBTB11		Antibodies for ZBTB11
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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ZBTB11 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for ZBTB11

Summaries
for ZBTB11

Genomic Location
for ZBTB11

Proteins
for ZBTB11

Protein Domains/
Families
for ZBTB11

Gene Function
for ZBTB11

Pathways & Interactions
for ZBTB11

Drugs & Compounds
for ZBTB11

Transcripts
for ZBTB11

Expression
for ZBTB11

Orthologs
for ZBTB11

Paralogs
for ZBTB11

SNPs/Variants
for ZBTB11

Disorders & Mutations
for ZBTB11

Medical News
for ZBTB11

Publications
for ZBTB11

Search for ZBTB11

Genome Databases showing ZBTB11

Other Databases showing ZBTB11

Specialized Databases showing ZBTB11

Licensable Technologies
for ZBTB11

Services
for ZBTB11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBTB11 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor ZBTB11

Summariesfor ZBTB11

Genomic Locationfor ZBTB11

Proteinsfor ZBTB11

Protein Domains/Familiesfor ZBTB11

Gene Functionfor ZBTB11

Pathways & Interactionsfor ZBTB11

Drugs & Compoundsfor ZBTB11

Transcriptsfor ZBTB11

Expression for ZBTB11

Orthologsfor ZBTB11

Paralogsfor ZBTB11

SNPs/Variantsfor ZBTB11

Disorders & Mutationsfor ZBTB11

Medical Newsfor ZBTB11

Publicationsfor ZBTB11

Search for ZBTB11

Genome Databases showing ZBTB11

Other Databases showing ZBTB11

Specialized Databases showing ZBTB11

Licensable Technologiesfor ZBTB11

Servicesfor ZBTB11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBTB11

Summaries
for ZBTB11

Genomic Location
for ZBTB11

Proteins
for ZBTB11

Protein Domains/
Families
for ZBTB11

Gene Function
for ZBTB11

Pathways & Interactions
for ZBTB11

Drugs & Compounds
for ZBTB11

Transcripts
for ZBTB11

Expression
for ZBTB11

Orthologs
for ZBTB11

Paralogs
for ZBTB11

SNPs/Variants
for ZBTB11

Disorders & Mutations
for ZBTB11

Medical News
for ZBTB11

Publications
for ZBTB11

Licensable Technologies
for ZBTB11

Services
for ZBTB11