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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB11 Gene

protein-coding   GIFtS: 47
GCID: GC03M101367

Zinc Finger And BTB Domain Containing 11

  Search for ZBTB11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 111 2
ZNF-U692742
ZNF9132
Zinc Finger And BTB Domain-Containing Protein 112

External Ids:    HGNC: 167401   Entrez Gene: 271072   Ensembl: ENSG000000664227   UniProtKB: O956253   

Export aliases for ZBTB11 gene to outside databases

Previous GC identifers: GC03M102690 GC03M102850 GC03M098737


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB11 Gene: 
ZBTB11 (zinc finger and BTB domain containing 11) is a protein-coding gene. GO annotations related to this gene include DNA binding and molecular_function. An important paralog of this gene is ZBTB48.

UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZBTB11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB11 gene promoter:
         AML1a   ATF-2   POU3F1   HTF   GATA-2   CREB   Ik-2   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB11 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.3   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3q12.3

ZBTB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M101367:  view genomic region     (about GC identifiers)

Start:
101,367,733 bp from pter      End:
101,396,339 bp from pter
Size:
28,607 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 11  
Size: 1053 amino acids; 119384 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q2NKP9

Explore the universe of human proteins at neXtProt for ZBTB11: NX_O95625

Explore proteomics data for ZBTB11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95625

  • ZBTB11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB11 Protein Expression
    REFSEQ proteins: NP_055230.2  
    ENSEMBL proteins: 
     ENSP00000326200   ENSP00000417369  

    Human Recombinant Protein Products for ZBTB11: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZBTB11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    ZBTB11 for ontologies           About GeneDecksing



    ZBTB11 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ZBTB11 
    Cloud-Clone Corp. CLIAs for ZBTB11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry O95625

    ProtoNet protein and cluster: O95625

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 12 C2H2-type zinc fingers


    ZBTB11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT11_HUMAN, O95625
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB11:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZBTB11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB11 
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    miRNA
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB11 (see all 60):
    hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4328 hsa-miR-4272 hsa-miR-578 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZBTB11 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB11

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZBTB11 (O956252, 3 ENSP000003262004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD7O151052, 3MINT-61818 I2D: score=3 
    RAPGEF2Q9Y4G83I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    SIRT7ENSP000003294664STRING: ENSP00000329466
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--

    ZBTB11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB11 (ZBT11)

    Search CenterWatch for drugs/clinical trials and news about ZBTB11 / ZBT11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB11 gene: 
    NM_014415.3  

    Unigene Cluster for ZBTB11:

    Zinc finger and BTB domain containing 11
    Hs.655286  [show with all ESTs]
    Unigene Representative Sequence: NM_014415
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312938(uc003dve.4) ENST00000471673 ENST00000461821(uc003dvf.2)

    miRNA
    Products:
         
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB11 (see all 60):
    hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4328 hsa-miR-4272 hsa-miR-578 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZBTB11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB11
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB11
    Sirion Biotech Customized lentivirus for stable overexpression of ZBTB11 
                         Customized lentivirus expression plasmids for stable overexpression of ZBTB11 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB11

    Additional mRNA sequence: 

    AB208862.1 AK023488.1 AK312859.1 BC028062.1 BC029342.1 BC111700.1 U69274.1 

    9 DOTS entries:

    DT.95315652  DT.308117  DT.207187  DT.91650245  DT.100000676  DT.120845508  DT.207188  DT.86846301 
    DT.99928948 

    24/112 AceView cDNA sequences (see all 112):

    AI636025 AI298175 BC028062 CB161435 BU174971 BC029342 AW514881 BU189236 
    CB215880 AA361624 N51926 AW272168 BM839526 Z30284 CA389273 AI522100 
    CR598311 AK023488 BM473764 AI375204 BP362007 CB163165 BQ022066 BM463877 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAAAAG
    ZBTB11 Expression
    About this image


    See ZBTB11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB11

    SOURCE GeneReport for Unigene cluster: Hs.655286
        SABiosciences Custom PCR Arrays for ZBTB11
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZBTB11 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb111 , 5 zinc finger and BTB domain containing 111, 5 87.08(n)1
    89.52(a)1
      16 (33.74 cM)5
    2713771  NM_173026.21  NP_766614.21 
     559738045 
    chicken
    (Gallus gallus)
    Aves ZBTB111 zinc finger and BTB domain containing 11 71.91(n)
    74.14(a)
      418400  XM_416615.3  XP_416615.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB116
    Uncharacterized protein
    69(a)
    1 ↔ 1
    3(173587920-173606021)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480506322   -- 75.11(n)    48050632 
    zebrafish
    (Danio rerio)
    Actinopterygii 570616852   -- 74.45(n)    57061685 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIIalpha-i16
    Cp1906
    Centrosomal protein 190kD
    20(a)
    12(a)
    many → 1
    many → 1
    3L(15810079-15811721)
    3R(11096146-11100927)


    ENSEMBL Gene Tree for ZBTB11 (if available)
    TreeFam Gene Tree for ZBTB11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB11 gene
    ZBTB482  ZBTB172  
    2 SIMAP similar genes for ZBTB11 using alignment to 3 protein entries:     ZBT11_HUMAN (see all proteins):
    ZNF501    ZNF80

    ZBTB11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/589 SNPs in ZBTB11 are shown (see all 589)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0218944
    ----see VAR_0218942 G S mis40--------
    rs1853726171,2
    --101367828(+) TGGATA/GGGGAG 1 -- int10--------
    rs560724521,2
    C,F--101367909(+) AGATGC/TTCCTC 1 -- int15Minor allele frequency- T:0.09NA CSA WA EA 362
    rs1438483701,2
    --101367932(+) TGCCGC/TAACAC 1 -- int10--------
    rs1157411831,2
    C,F--101367934(+) CCGCAA/GCACTC 1 -- int11Minor allele frequency- G:0.23WA 118
    rs1506236611,2
    --101367984(+) ACAGGA/CTAGGA 1 -- int10--------
    rs1161440901,2
    F--101367987(+) GGATAG/CGAGGG 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1151169411,2
    C,F--101367994(+) AGGGCG/ATGGTG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1387828351,2
    --101368016(+) AACATG/TTGGGC 1 -- int10--------
    rs1166402671,2
    C,F--101368171(+) CCAATC/TGTTAT 1 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for ZBTB11 (101367733 - 101396339 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZBTB11: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB11
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB11 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ZBTB11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    3. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    4. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27107 HGNC: 16740 AceView: ZBTB11 Ensembl:ENSG00000066422 euGenes: HUgn27107
    ECgene: ZBTB11 H-InvDB: ZBTB11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB11 gene:
    Search GeneIP for patents involving ZBTB11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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