ZBTB11 Gene
protein-coding GIFtS: 46
GCID: GC03M101367
|
|
zinc finger and BTB domain containing 11
| |
Aliases
for ZBTB11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 111 2 | | ZNF-U692741 2 | | ZNF9131 2 | | Zinc Finger And BTB Domain-Containing Protein 112 |
Export aliases for ZBTB11 gene to outside databasesPrevious GC identifers: GC03M102690 GC03M102850 GC03M098737 |
Summaries
for ZBTB11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625Function: May be involved in transcriptional regulation
Gene Wiki entry for ZBTB11
|
Genomic Views
for ZBTB11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB11 gene promoter:
AML1a ATF-2 POU3F1 HTF GATA-2 CREB Ik-2 POU2F1 POU2F1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q12.3 Ensembl cytogenetic band: 3q12.3 HGNC cytogenetic band: 3q12.3ZBTB11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M101367: view genomic region
(about GC identifiers)
Start:
|
101,367,733 bp from pter |
End:
|
101,396,339 bp from pter |
Size:
|
28,607 bases |
Orientation:
|
minus strand |
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Proteins
for ZBTB11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 11 Size: 1053 amino acids; 119384 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q2NKP9Explore the universe of human proteins at neXtProt for ZBTB11: NX_O95625
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95625
ZBTB11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055230.2
ENSEMBL proteins: ENSP00000326200 ENSP00000417369
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZBTB11 for ontologies About GeneDecksing
ZBTB11 Antibody Products:
Assay Products for ZBTB11: |
Protein
Domains /
Families
for ZBTB11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB11 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O95625ProtoNet protein and cluster: O95625 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 12 C2H2-type zinc fingers |
Function
for ZBTB11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB11 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZBTB11 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZBTB11:
|
Pathways & Interactions
for ZBTB11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB11
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for ZBTB11 (O956252, 3 ENSP000003262004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ZBTB11 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB11
Search CenterWatch for drugs/clinical trials and news about ZBTB11 / ZBT11
|
Transcripts
for ZBTB11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB11 gene: NM_014415.3 Unigene Cluster for ZBTB11: Zinc finger and BTB domain containing 11 Hs.655286 [show with all ESTs]Unigene Representative Sequence: NM_0144153 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312938(uc003dve.4) ENST00000471673 ENST00000461821(uc003dvf.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBTB11 (NM_014415) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB11 |
Additional cDNA sequence: AB208862.1 AK023488.1 AK312859.1 BC028062.1 BC029342.1 BC111700.1 U69274.1 9 DOTS entries: DT.95315652 DT.308117 DT.207187 DT.91650245 DT.100000676 DT.120845508 DT.207188 DT.86846301 DT.99928948 24/112 AceView cDNA sequences (see all 112): CR598311 AI571122 BC029342 BQ022066 CA389273 BM473764 BM463877 AW514881 CB215880 AI522100 BP362007 AK023488 CB161533 BX956437 AW014174 BU174971 Z30284 BU189236 BM839526 CB163165 AW272168 AA361624 BC028062 AI636025
GeneLoc Exon Structure
|
Expression
for ZBTB11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATAAAAG
About this image
See ZBTB11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB11
SOURCE GeneReport for Unigene cluster: Hs.655286
SABiosciences Custom PCR Arrays for ZBTB11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB11 |
Orthologs
for ZBTB11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZBTB11 gene from 6/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Zbtb111 , 5 |
zinc finger and BTB domain containing 111, 5 |
87.08(n)1
89.52(a)1 |
|
16 (33.74 cM)5
2713771 NM_173026.21 NP_766614.21
559738045 |
chicken
(Gallus gallus) |
Aves |
ZBTB111 |
zinc finger and BTB domain containing 11 |
71.91(n)
74.14(a) |
|
418400 XM_416615.3 XP_416615.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ZBTB116 |
-- |
70(a) |
1 ↔ 1 |
3(173587920-173606021) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480506322 |
-- |
75.11(n) |
|
48050632 |
zebrafish
(Danio rerio) |
Actinopterygii |
570616852 |
-- |
74.45(n) |
|
57061685 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CkIIalpha-i16 |
CKII-alpha subunit interactor-1 |
24(a) |
1 ↔ 1 |
3L(15810079-15811721) |
ENSEMBL Gene Tree for ZBTB11 (if available)
TreeFam Gene Tree for ZBTB11 (if available) |
Paralogs
for ZBTB11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ZBTB11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB11 (101367733 - 101396339 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB11 |
|
Disorders
/ Diseases
for ZBTB11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZBTB11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB11 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ZBTB11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
|
External Searches for ZBTB11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB11 gene:
Search GeneIP for patents involving ZBTB11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | ZBTB11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB11 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB11 |
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