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ZBTB11 Gene

protein-coding   GIFtS: 49
GCID: GC03M101367

Zinc Finger And BTB Domain Containing 11

  Search for ZBTB11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 111 2
ZNF-U692742
ZNF9132
Zinc Finger And BTB Domain-Containing Protein 112

External Ids:    HGNC: 167401   Entrez Gene: 271072   Ensembl: ENSG000000664227   UniProtKB: O956253   

Export aliases for ZBTB11 gene to outside databases

Previous GC identifers: GC03M102690 GC03M102850 GC03M098737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB11 Gene:
ZBTB11 (zinc finger and BTB domain containing 11) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZBTB11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB11 gene promoter:
         AML1a   ATF-2   POU3F1   HTF   GATA-2   CREB   Ik-2   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB11 promoter sequence
   Search Chromatin IP Primers for ZBTB11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.3   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3q12.3

ZBTB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB11 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M101367:  view genomic region     (about GC identifiers)

Start:
101,367,733 bp from pter      End:
101,396,339 bp from pter
Size:
28,607 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 11  
Size: 1053 amino acids; 119384 Da
Secondary accessions: Q2NKP9

Explore the universe of human proteins at neXtProt for ZBTB11: NX_O95625

Explore proteomics data for ZBTB11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055230.2  
    ENSEMBL proteins: 
     ENSP00000326200   ENSP00000417369  

    ZBTB11 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for ZBTB11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O95625

    ProtoNet protein and cluster: O95625

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBT11_HUMAN, O95625
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 12 C2H2-type zinc fingers


    Find genes that share domains with ZBTB11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT11_HUMAN, O95625
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZBTB11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB11:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBTB11
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB11

    miRNA
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    miRTarBase miRNAs that target ZBTB11:
    hsa-mir-877-5p (MIRT037233)

    Block miRNA regulation of human, mouse, rat ZBTB11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB11 (see all 60):
    hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4328 hsa-miR-4272 hsa-miR-578 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZBTB11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ZBTB11
    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB11

    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBT11_HUMAN, O95625: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with ZBTB11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB11
    Interactions:

        Search GeneGlobe Interaction Network for ZBTB11

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZBTB11 (O956252, 3 ENSP000003262004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD7O151052, 3MINT-61818 I2D: score=3 
    RAPGEF2Q9Y4G83I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    SIRT7ENSP000003294664STRING: ENSP00000329466
    PPP1CAENSP000003260314STRING: ENSP00000326031
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with ZBTB11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB11 (ZBT11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBTB11 gene: 
    NM_014415.3  

    Unigene Cluster for ZBTB11:

    Zinc finger and BTB domain containing 11
    Hs.655286  [show with all ESTs]
    Unigene Representative Sequence: NM_014415
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312938(uc003dve.4) ENST00000471673 ENST00000461821(uc003dvf.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZBTB11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBTB11 (see all 60):
    hsa-miR-548j hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4328 hsa-miR-4272 hsa-miR-578 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidZBTB11 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat ZBTB11
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB11
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB11
      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB11
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB11

    Additional mRNA sequence: 

    AB208862.1 AK023488.1 AK312859.1 BC028062.1 BC029342.1 BC111700.1 U69274.1 

    9 DOTS entries:

    DT.95315652  DT.308117  DT.207187  DT.91650245  DT.100000676  DT.120845508  DT.207188  DT.86846301 
    DT.99928948 

    Selected AceView cDNA sequences (see all 112):

    AW514881 CA389273 AI522100 CR598311 N51926 AK023488 BC029342 Z30284 
    AW014174 AI571122 BX483910 CB161533 AW272168 BM473764 CB161435 BU189236 
    BM839526 BC028062 BM463877 CB163165 BX956437 BU174971 AI375204 AA361624 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAAAAG
    ZBTB11 Expression
    About this image


    ZBTB11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ZBTB11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655286
        Custom PCR Arrays for ZBTB11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZBTB11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb111 , 5 zinc finger and BTB domain containing 111, 5 87.08(n)1
    89.52(a)1
      16 (33.74 cM)5
    2713771  NM_173026.21  NP_766614.21 
     559738835 
    chicken
    (Gallus gallus)
    Aves ZBTB111 zinc finger and BTB domain containing 11 72.2(n)
    74.6(a)
      418400  XM_416615.4  XP_416615.4 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB116
    zinc finger and BTB domain containing 11
    69(a)
    1 ↔ 1
    3(173587920-173606021)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480506322   -- 75.11(n)    48050632 
    zebrafish
    (Danio rerio)
    Actinopterygii 570616852   -- 74.45(n)    57061685 
    fruit fly
    (Drosophila melanogaster)
    Insecta CkIIalpha-i16
    CKII-alpha subunit interactor-1
    27(a)
    1 ↔ 1
    3L(15810079-15811721)


    ENSEMBL Gene Tree for ZBTB11 (if available)
    TreeFam Gene Tree for ZBTB11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB11 gene
    2 SIMAP similar genes for ZBTB11 using alignment to 3 protein entries:     ZBT11_HUMAN (see all proteins):
    ZNF501    ZNF80

    Find genes that share paralogs with ZBTB11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB11 (see all 589)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853726171,2
    --101367828(+) TGGATA/GGGGAG 1 -- int10--------
    rs560724521,2
    C,F--101367909(+) AGATGC/TTCCTC 1 -- int15Minor allele frequency- T:0.09NA CSA WA EA 362
    rs1438483701,2
    --101367932(+) TGCCGC/TAACAC 1 -- int10--------
    rs1157411831,2
    C,F--101367934(+) CCGCAA/GCACTC 1 -- int11Minor allele frequency- G:0.23WA 118
    rs1506236611,2
    --101367984(+) ACAGGA/CTAGGA 1 -- int10--------
    rs1161440901,2
    F--101367987(+) GGATAG/CGAGGG 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1151169411,2
    C,F--101367994(+) AGGGCG/ATGGTG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1387828351,2
    --101368016(+) AACATG/TTGGGC 1 -- int10--------
    rs1166402671,2
    C,F--101368171(+) CCAATC/TGTTAT 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1493895711,2
    --101368243(+) CAACTC/GATTTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZBTB11 (101367733 - 101396339 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ZBTB11: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB11
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB11 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZBTB11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27107 HGNC: 16740 AceView: ZBTB11 Ensembl:ENSG00000066422 euGenes: HUgn27107
    ECgene: ZBTB11 H-InvDB: ZBTB11

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB11 gene:
    Search GeneIP for patents involving ZBTB11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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