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Aliases for ZBTB10 Gene

Aliases for ZBTB10 Gene

  • Zinc Finger And BTB Domain Containing 10 2 3 5
  • Zinc Finger Protein RIN ZF 3 4
  • RINZF 3 4
  • Zinc Finger And BTB Domain-Containing Protein 10 3
  • Zinc Finger Protein RINZF 3
  • RINZFC 4

External Ids for ZBTB10 Gene

Previous GeneCards Identifiers for ZBTB10 Gene

  • GC08P081447
  • GC08P081448
  • GC08P081561
  • GC08P076888

Summaries for ZBTB10 Gene

GeneCards Summary for ZBTB10 Gene

ZBTB10 (Zinc Finger And BTB Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is ZBTB46.

UniProtKB/Swiss-Prot for ZBTB10 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB10 Gene

Genomics for ZBTB10 Gene

Regulatory Elements for ZBTB10 Gene

Enhancers for ZBTB10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F080240 1.2 Ensembl ENCODE 10.5 -244.9 -244919 1.0 ELF3 ZNF76 ARID4B SIN3A ZNF48 ZNF2 RAD21 RARA ZNF143 MIXL1 ENSG00000206649 ENSG00000251867 ZBTB10 RNU6-1213P RNU2-71P MIR5708 LOC105375920
GH08F080330 0.9 ENCODE 11 -154.9 -154909 0.1 PKNOX1 ZNF133 INSM2 KLF17 FEZF1 ZNF48 ZNF391 OVOL3 REST ZNF645 LOC100216346 RPL13AP18 ENSG00000253238 RPL3P9 RNU6-1213P ENSG00000251867 ZBTB10 ENSG00000206649 GC08M080317
GH08F080508 0.6 Ensembl 11.8 +23.5 23482 1.8 NFIA ZFP3 SP5 BHLHE40 TBX21 PRDM1 ENSG00000251867 ZBTB10 RNU2-71P GC08M080419 ENSG00000254162
GH08F081049 1.4 FANTOM5 Ensembl ENCODE 4.9 +565.5 565482 2.8 INSM2 ZNF366 FOS ZNF362 CEBPB USF2 ZEB2 ZNF843 CEBPA ZNF24 PAG1 ZBTB10 ENSG00000254177 ENSG00000254060
GH08F080484 1.4 FANTOM5 ENCODE 4.7 +1.5 1486 4.7 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP5 ENSG00000251867 TPD52 ZBTB10 GC08M080419
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBTB10 on UCSC Golden Path with GeneCards custom track

Promoters for ZBTB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001395075 1981 5201 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS SP5

Genomic Location for ZBTB10 Gene

Chromosome:
8
Start:
80,485,619 bp from pter
End:
80,526,265 bp from pter
Size:
40,647 bases
Orientation:
Plus strand

Genomic View for ZBTB10 Gene

Genes around ZBTB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB10 Gene

Proteins for ZBTB10 Gene

  • Protein details for ZBTB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DT7-ZBT10_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 10
    Protein Accession:
    Q96DT7
    Secondary Accessions:
    • A4FVD0
    • Q86W96
    • Q8IXI9
    • Q96MH9

    Protein attributes for ZBTB10 Gene

    Size:
    871 amino acids
    Molecular mass:
    94894 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB10 Gene

Post-translational modifications for ZBTB10 Gene

  • Ubiquitination at Lys 460
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB10 Gene

No data available for DME Specific Peptides for ZBTB10 Gene

Domains & Families for ZBTB10 Gene

Gene Families for ZBTB10 Gene

Suggested Antigen Peptide Sequences for ZBTB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DT7

UniProtKB/Swiss-Prot:

ZBT10_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB10: view

Function for ZBTB10 Gene

Molecular function for ZBTB10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBTB10: view

Phenotypes for ZBTB10 Gene

genes like me logo Genes that share phenotypes with ZBTB10: view

Animal Model Products

miRNA for ZBTB10 Gene

miRTarBase miRNAs that target ZBTB10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB10 Gene

Localization for ZBTB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBTB10 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZBTB10: view

Pathways & Interactions for ZBTB10 Gene

SuperPathways for ZBTB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZBTB10: view

No data available for Pathways by source and SIGNOR curated interactions for ZBTB10 Gene

Transcripts for ZBTB10 Gene

Unigene Clusters for ZBTB10 Gene

Zinc finger and BTB domain containing 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB10 Gene

No ASD Table

Relevant External Links for ZBTB10 Gene

GeneLoc Exon Structure for
ZBTB10
ECgene alternative splicing isoforms for
ZBTB10

Expression for ZBTB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBTB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB10 Gene

This gene is overexpressed in Bone (34.4), Heart (21.7), Liver (6.6), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB10 Gene



Protein tissue co-expression partners for ZBTB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBTB10 Gene:

ZBTB10

SOURCE GeneReport for Unigene cluster for ZBTB10 Gene:

Hs.591868
genes like me logo Genes that share expression patterns with ZBTB10: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB10 Gene

Orthologs for ZBTB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB10 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia ZBTB10 34 35
  • 95 (n)
cow
(Bos Taurus)
Mammalia ZBTB10 34 35
  • 94.71 (n)
rat
(Rattus norvegicus)
Mammalia Zbtb10 34
  • 90.71 (n)
mouse
(Mus musculus)
Mammalia Zbtb10 34 16 35
  • 89.29 (n)
oppossum
(Monodelphis domestica)
Mammalia ZBTB10 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB10 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBTB10 34 35
  • 79.72 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb10 34
  • 70.3 (n)
Str.915 34
zebrafish
(Danio rerio)
Actinopterygii zbtb10 34 35
  • 61.74 (n)
Species where no ortholog for ZBTB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB10 Gene

ENSEMBL:
Gene Tree for ZBTB10 (if available)
TreeFam:
Gene Tree for ZBTB10 (if available)

Paralogs for ZBTB10 Gene

(9) SIMAP similar genes for ZBTB10 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZBTB10 Gene

genes like me logo Genes that share paralogs with ZBTB10: view

Variants for ZBTB10 Gene

Sequence variations from dbSNP and Humsavar for ZBTB10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10046715 -- 80,509,803(+) AGGAG(A/G)TAGGG intron-variant
rs10093068 -- 80,519,415(+) AATAC(C/G)AGGAG reference, missense
rs10094511 -- 80,507,385(+) aggcg(A/G)gtggt intron-variant
rs10095139 -- 80,485,033(+) AGTTC(A/G)TGATT intron-variant, upstream-variant-2KB
rs10102597 -- 80,509,548(+) ATTTG(A/G)AAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB10 Gene

Variant ID Type Subtype PubMed ID
nsv1117835 CNV deletion 24896259
esv3339644 CNV insertion 20981092
esv3305015 CNV mobile element insertion 20981092

Variation tolerance for ZBTB10 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBTB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB10 Gene

Disorders for ZBTB10 Gene

Relevant External Links for ZBTB10

Genetic Association Database (GAD)
ZBTB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB10

No disorders were found for ZBTB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB10 Gene

Publications for ZBTB10 Gene

  1. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N. … Do C.B. (PLoS ONE 2012) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64

Products for ZBTB10 Gene

Sources for ZBTB10 Gene

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