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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB10 Gene

protein-coding   GIFtS: 46
GCID: GC08P081448

Zinc Finger And BTB Domain Containing 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 101 2
Zinc Finger Protein RIN ZF2 3
RINZF2 3
Zinc Finger And BTB Domain-Containing Protein 102
Zinc Finger Protein RINZF2
RINZFC3

External Ids:    HGNC: 309531   Entrez Gene: 659862   Ensembl: ENSG000002051897   UniProtKB: Q96DT73   

Export aliases for ZBTB10 gene to outside databases

Previous GC identifers: GC08P081447 GC08P081561 GC08P076888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB10 Gene: 
ZBTB10 (zinc finger and BTB domain containing 10) is a protein-coding gene. Diseases associated with ZBTB10 include hypothyroidism, and atopic dermatitis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZBTB18.

UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB10 gene promoter:
         E2F-4   E2F-3a   E2F-5   HNF-4alpha2   E2F-2   NF-kappaB   HNF-4alpha1   GATA-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBTB10 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13-q21.1   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q13-q21.1

ZBTB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB10 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P081448:  view genomic region     (about GC identifiers)

Start:
81,397,854 bp from pter      End:
81,438,500 bp from pter
Size:
40,647 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 10  
Size: 871 amino acids; 94894 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A4FVD0 Q86W96 Q8IXI9 Q96MH9
Alternative splicing: 4 isoforms:  Q96DT7-1   Q96DT7-2   Q96DT7-3   Q96DT7-4   

Explore the universe of human proteins at neXtProt for ZBTB10: NX_Q96DT7

Explore proteomics data for ZBTB10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DT7

  • ZBTB10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001099009.1  NP_001264074.1  NP_076418.3  

    ENSEMBL proteins: 
     ENSP00000368384   ENSP00000387462   ENSP00000412036   ENSP00000416134  

    Human Recombinant Protein Products for ZBTB10: 
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    Cloud-Clone Corp. Proteins for ZBTB10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZBTB10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q96DT7

    ProtoNet protein and cluster: Q96DT7

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011069 Aspartate carbamoyltransferase


    UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 2 C2H2-type zinc fingers


    ZBTB10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBT10_HUMAN, Q96DT7
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZBTB10 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ZBTB10:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB10
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB10 (see all 53):
    hsa-let-7d hsa-miR-4328 hsa-miR-513a-5p hsa-miR-29a hsa-miR-139-5p hsa-miR-30d hsa-miR-3923 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidZBTB10 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZBTB10 (ENSP000003874624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZBTB10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB10 (ZBT10)

    Search CenterWatch for drugs/clinical trials and news about ZBTB10 / ZBT10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB10 gene (3 alternative transcripts): 
    NM_001105539.2  NM_001277145.1  NM_023929.4  

    Unigene Cluster for ZBTB10:

    Zinc finger and BTB domain containing 10
    Hs.591868  [show with all ESTs]
    Unigene Representative Sequence: NM_001105539
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379091 ENST00000430430(uc003ybv.4) ENST00000455036 ENST00000426744(uc003ybw.4 uc003ybx.4 uc022awq.1 uc010lzt.3 uc022awr.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB10
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB10 (see all 53):
    hsa-let-7d hsa-miR-4328 hsa-miR-513a-5p hsa-miR-29a hsa-miR-139-5p hsa-miR-30d hsa-miR-3923 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidZBTB10 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB10

    Additional mRNA sequence: 

    AJ319673.1 AK022814.1 AK024296.1 AK056913.1 BC050061.1 BC127097.1 BC127098.1 BC148254.1 

    9 DOTS entries:

    DT.75123010  DT.100749485  DT.40118396  DT.100721031  DT.409784  DT.109923  DT.40229963  DT.101955715 
    DT.120649046 

    24/137 AceView cDNA sequences (see all 137):

    AV727684 AA609219 BM315089 BF056208 AW515620 BF939955 CF144682 AK024296 
    AK056913 AL700223 AL700154 AL599842 AI568973 BQ024540 AW001886 AI090104 
    BC050061 AI271348 AU132566 AA669343 AL535989 CF144390 AW468097 AW293310 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCGAGGG
    ZBTB10 Expression
    About this image


    See ZBTB10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB10

    SOURCE GeneReport for Unigene cluster: Hs.591868
        SABiosciences Custom PCR Arrays for ZBTB10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB10 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb101 , 5 zinc finger and BTB domain containing 101, 5 89.96(n)1
    89.38(a)1
      3 (2.25 cM)5
    2290551  NM_177660.31  NP_808328.21 
     92506025 
    chicken
    (Gallus gallus)
    Aves ZBTB101 zinc finger and BTB domain containing 10 80.7(n)
    81.65(a)
      428366  XM_003640808.1  XP_003640856.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    ZBTB106
    Uncharacterized protein
    88(a)
    76(a)
    1 ↔ many
    1 ↔ many
    4(24922682-24933601)
    4(24947459-24948298)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA792638.12   -- 81.38(n)    CA792638.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zbtb101 zinc finger and BTB domain containing 10 59.89(n)
    57.53(a)
      566269  NM_001128539.1  NP_001122011.1 


    ENSEMBL Gene Tree for ZBTB10 (if available)
    TreeFam Gene Tree for ZBTB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB10 gene
    ZBTB182  ZBTB212  ZBTB32  ZBTB142  ZBTB7B2  ENSG000002545532  ZBTB462  ZBTB7C2  
    ZBTB8B2  ZBTB8A2  ZBTB7A2  ZBTB52  ZBTB442  ZBTB492  ZBTB242  ZBTB422  
    MYNN2  
    9 SIMAP similar genes for ZBTB10 using alignment to 2 protein entries:     ZBT10_HUMAN (see all proteins):
    BACH2    KLHL32    ZBTB46    DKFZp434J0650    ZNF55    DKFZp547H249
    ZFS-2    ZNF78L1    ZNF808

    ZBTB10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZBTB10
    PGOHUM00000250532


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/830 SNPs in ZBTB10 are shown (see all 830)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876521111,2
    --81396040(+) CGCCCG/TTCTCG 1 -- us2k10--------
    rs1404809361,2
    --81396141(+) CCTAGA/GTAAGT 1 -- us2k10--------
    rs1504353311,2
    --81396247(+) AAAAAA/CAAACA 1 -- us2k10--------
    rs1925594331,2
    --81396255(+) ACACGC/TATTAA 1 -- us2k10--------
    rs1847838371,2
    --81396449(+) CCCTAA/CAACTG 3 -- us2k10--------
    rs1884629641,2
    --81396495(+) CTTGGC/TCACTG 3 -- us2k10--------
    rs1917587971,2
    --81396513(+) GGTGAC/TAATAT 3 -- us2k10--------
    rs1380093241,2
    --81396733(+) ATGTGA/GATTCA 3 -- us2k10--------
    rs1494536641,2
    C--81396771(+) AAAAC-/GGTCTT 3 -- us2k10--------
    rs101091731,2
    C--81396831(+) AAGACT/CAGTCA 3 -- us2k13Minor allele frequency- C:0.09CSA NA EA 242

    HapMap Linkage Disequilibrium report for ZBTB10 (81397854 - 81438500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ZBTB10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv269293CNV Insertion20981092
    esv272175CNV Insertion20981092

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for ZBTB10:    About MalaCards
    hypothyroidism    atopic dermatitis    dermatitis    breast cancer


    ZBTB10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZBTB10

    Export disorders for ZBTB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB10 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ZBTB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1, 4 Eriksson N....Do C.B. (2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    6. Meta-analysis of genome-wide association studies ident ifies three new risk loci for atopic dermatitis. (PubMed id 22197932)1 Paternoster L....Weidinger S. (2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. (PubMed id 22895009)1 Gomez-Ferreria M.A....Pelletier L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65986 HGNC: 30953 AceView: ZBTB10 Ensembl:ENSG00000205189 euGenes: HUgn65986
    ECgene: ZBTB10 H-InvDB: ZBTB10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB10 gene:
    Search GeneIP for patents involving ZBTB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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