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ZBTB10 Gene

protein-coding   GIFtS: 46

GC08P081561
zinc finger and BTB domain containing 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ12752 1, 2
RINZF 1, 2, 3
RINZFC 3
Descriptions
Zinc finger protein RIN ZF 3
zinc finger and BTB domain containing 10 2
zinc finger protein RINZF 2
External Ids
HGNC: 309531
Entrez Gene: 659862
UniProtKB: Q96DT73
Ensembl: ENSG000002051897
Search outside databases for aliases for ZBTB10 gene

Previous GC identifers: GC08P081447 GC08P081448

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7
Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB10 gene  

Entrez Gene cytogenetic band: 8q13-q21.1   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q13-q21.1

ZBTB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P081561:     (about GC identifiers)

Start:
81,560,574 bp from pter
End:
81,597,165 bp from pter
Size:
36,592 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000008.9  NT_008183.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 10  
Size: 847 amino acids; 92444 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q86W96 Q8IXI9 Q96MH9
Alternative splicing: 2 isoforms:  Q96DT7-1   Q96DT7-2   

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001099009.1  NP_076418.3  


    ENSEMBL proteins: 
    ENSP00000368378 ENSP00000368384 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZBT10)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB10: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB10
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZBT10), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ZBTB10)
    Search Novus for antibodies for ZBTB10

    Assays for ZBTB10: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB10 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q96DT7

    ProtoNet protein and cluster: Q96DT7

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB011069 Aspartate carbamoyltransferase


    UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 2 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB10)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_023929

                  Applied Biosystems Silencer® siRNAs for ZBTB10

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB10  
                         Sigma-Aldrich shRNA for ZBTB10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105539
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105539
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001105539 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001105539

    UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7
    Function: May be involved in transcriptional regulation

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB10

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ZBTB10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB10)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_023929

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB10  
                         Sigma-Aldrich shRNA for ZBTB10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001105539  NM_023929  

    REFSEQ mRNAs for ZBTB10 gene (2 alternative transcripts): 

    NM_001105539.1   NM_023929.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001105539  NM_023929  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105539
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105539
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001105539 

    Additional cDNA sequence: 

    AJ319673.1 AK022814.1 AK024296.1 AK056913.1 BC050061.1 BC127097.1 BC127098.1 BC148254.1 

    5 DOTS entries:

    DT.75123010  DT.100749485  DT.100721031  DT.40229963  DT.120649046 

    24/137 AceView cDNA sequences (see all 137 ):

    AA669343 AK024296 AI090104 AI271348 AL599842 CF144682 AI280331 AW468097 
    BM315089 AI568973 AU132566 BQ024540 CF144390 AW515620 AK056913 BC050061 
    AI220012 AW293310 AL700154 AV727684 BF056208 BF939955 AL535989 AL700223 

    highest scoring ESTs for ZBTB10:

    AI089817 AI271348 AJ319673 AK022814 AK056913 AL596769 AL700154 AL700223 AL709294 BC050061 

    Unigene Cluster for ZBTB10:

    Zinc finger and BTB domain containing 10
    Hs.591868  [show with all ESTs]
    Unigene Representative Sequence: NM_001105539


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000379085  ENST00000379091  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB10 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB10

    1 / 2 / 3

    11 probe-sets matching ZBTB10 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    82828_at2, 3 U95-D 1 1.00 1.00 0.95 1.14 AI089817 0.80 1.00 0.91 1

    44838_at2, 3 U95-B 1 1.00 1.00 0.89 0.90 AI271348 0.80 1.00 0.91 1

    76476_at2, 3 U95-E 1 0.88 1.00 -0.21 0.97 AI830416 0.40 1.00 0.76 1

    233899_x_at2, 3 U133-B 1 1.00 1.00 -- -- AK024296 0.40 1.00 0.76 1

    219312_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_023929 0.60 1.00 0.82 1

    235726_at2, 3 U133-B 1 0.82 1.00 -- -- AI830416 0.40 1.00 0.76 1

    222863_at*2, 3 U133-B NULL 0.00 0.00 -- -- BG483802 0.20 1.00 0.72 1

    233899_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    219312_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    235726_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --

    222863_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    GeneDecks  ZBTB10 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ATCTCGAGGG

    SOURCE GeneReport for Unigene cluster: Hs.591868
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ZBTB10 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ZBTB101   -- zinc finger and BTB domain containing 10 95.42(n)
    97.25(a)
    487014  XM_848414.1  XP_853507.1 
    chimpanzee
    (Pan troglodytes)
    ZBTB101   -- zinc finger and BTB domain containing 10 99.8(n)
    99.76(a)
    464251  XM_519826.2  XP_519826.2 
    cow
    (Bos taurus)
    ZBTB101   -- zinc finger and BTB domain containing 10 94.44(n)
    94.32(a)
    785123  XM_001253244.1  XP_001253245.1 
    rat
    (Rattus norvegicus)
    Zbtb101   -- zinc finger and BTB domain containing 10 90.52(n)
    90.02(a)
    80338  NM_024489.1  NP_077815.1 
    mouse
    (Mus musculus)
    Zbtb101, 5 35
    zinc finger and BTB domain containing 101, 5 89.96(n)1
    89.38(a)1
    2290551  XM_485202.51  XP_485202.51 
     AA4669435  AA5296625  (see all 18)
    About this table        Species with no ortholog for ZBTB10

    ENSEMBL Gene Tree for ZBTB10
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB10 gene
    ZBTB462  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/165 NCBI SNPs in ZBTB10 are shown (see all 165 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 60)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs4060791,2
    A,C,F,H81559978(+) TAAAAA/TTTTTT 2 -- ng519Minor allele frequency- T:0.41EA NA MN EU WA 730
    rs10652381,2
    C,F,H81559660(-) AATAAT/AGTATT 2 -- ng515Minor allele frequency- A:0.21MN EU EA WA 596
    rs100930681,2
    C,H81594205(+) AATACG/CAGGAG 2 Q/E mis14Minor allele frequency- C:0.00EU EA WA 416
    rs4089251,2
    H81596841(-) AAAATC/GTGTCA 2 -- ut318Minor allele frequency- G:0.00EA NA MN EU WA 662
    --
    rs339552541,2
    F81595580(+) TAAAT-/CTAAA 
            
    TCTTC
    2 -- ut315Minor allele frequency- CTAAA:0.32EU EA NA MN 430
    rs5937471,2
    F81562122(+) TTGATG/ACAGGA 2 I/M mis1 ese31Minor allele frequency- A:0.03MN 184
    rs4238761,2
    C81560224(+) ATAACG/TTTATG 2 -- ng51 tfbs30--------
    rs4460011,2
    A,C,F,H,O81591272(+) TTAGAG/AATGTG 2 -- int111Minor allele frequency- A:0.43EU EA WA NA 978
    rs5622101,2
    A,C,F,H,O81570351(-) AAGCAT/GGTGTA 2 -- int17Minor allele frequency- G:0.43EU EA WA NA 556
    rs4814771,2
    A,C,F,H81587944(-) caaaaG/Aaaaaa 2 -- int1 trp37Minor allele frequency- A:0.43EA NA EU WA 472
    About this table

    HapMap Linkage Disequilibrium images for ZBTB10 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    6 PubMed articles for ZBTB10 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 65986 HGNC: 30953 AceView: ZBTB10 Ensembl:ENSG00000205189 euGenes: HUgn65986
    ECgene: ZBTB10 H-InvDB: ZBTB10
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB10:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB10-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB10 Antibodies for ZBTB10
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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