ZBTB10 Gene
protein-coding GIFtS: 44
GCID: GC08P081448
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|
zinc finger and BTB domain containing 10
| |
Aliases
for ZBTB10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger And BTB Domain Containing 101 2 | | Zinc Finger And BTB Domain-Containing Protein 102 | | RINZF1 2 3 | | Zinc Finger Protein RINZF2 | | Zinc Finger Protein RIN ZF2 3 | | RINZFC3 | | FLJ127521 | | |
Export aliases for ZBTB10 gene to outside databasesPrevious GC identifers: GC08P081447 GC08P081561 GC08P076888 |
Summaries
for ZBTB10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7Function: May be involved in transcriptional regulation
|
Genomic Views
for ZBTB10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBTB10 gene promoter:
E2F-4 E2F-3a E2F-5 HNF-4alpha2 E2F-2 NF-kappaB HNF-4alpha1 GATA-1 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBTB10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13-q21.1 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q13-q21.1ZBTB10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P081448: view genomic region
(about GC identifiers)
Start:
|
81,397,854 bp from pter |
End:
|
81,438,500 bp from pter |
Size:
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40,647 bases |
Orientation:
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plus strand |
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Proteins
for ZBTB10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7 (See
protein sequence)Recommended Name: Zinc finger and BTB domain-containing protein 10 Size: 871 amino acids; 94894 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A4FVD0 Q86W96 Q8IXI9 Q96MH9Alternative splicing: 4 isoforms: Q96DT7-1 Q96DT7-2 Q96DT7-3 Q96DT7-4 Explore the universe of human proteins at neXtProt for ZBTB10: NX_Q96DT7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96DT7
ZBTB10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001099009.1 NP_076418.3
ENSEMBL proteins: ENSP00000368384 ENSP00000387462 ENSP00000412036 ENSP00000429332 ENSP00000416134
Human Recombinant Protein Products for ZBTB10:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZBTB10 for ontologies About GeneDecksing
ZBTB10 Antibody Products:
Assay Products for ZBTB10: |
Protein
Domains /
Families
for ZBTB10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBTB10 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96DT7ProtoNet protein and cluster: Q96DT7 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011069 Aspartate carbamoyltransferase
UniProtKB/Swiss-Prot: ZBT10_HUMAN, Q96DT7Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 2 C2H2-type zinc fingers |
Function
for ZBTB10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZBT10_HUMAN, Q96DT7Function: May be involved in transcriptional regulation Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZBTB10 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB10 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB10 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZBTB10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB10 |
|
Pathways & Interactions
for ZBTB10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB10
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZBTB10 (ENSP000003874624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
-- | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZBTB10 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBTB10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBTB10
Search CenterWatch for drugs/clinical trials and news about ZBTB10 / ZBT10
|
Transcripts
for ZBTB10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBTB10 gene (2 alternative transcripts): NM_001105539.1 NM_023929.3 Unigene Cluster for ZBTB10: Zinc finger and BTB domain containing 10 Hs.591868 [show with all ESTs]Unigene Representative Sequence: NM_0011055395 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379091 ENST00000430430(uc003ybv.4) ENST00000455036 ENST00000519370
ENST00000426744(uc003ybw.4 uc003ybx.4 uc022awq.1 uc010lzt.3 uc022awr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB10 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB10 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZBTB10 (NM_001105539) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBTB10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB10 |
Additional cDNA sequence: AJ319673.1 AK022814.1 AK024296.1 AK056913.1 BC050061.1 BC127097.1 BC127098.1 BC148254.1 4 DOTS entries: DT.75123010 DT.100749485 DT.100721031 DT.40229963 24/137 AceView cDNA sequences (see all 137): BQ024540 AI090104 BC050061 AA669343 BF939955 BF056208 AI280331 AW293310 AL599842 AV727684 AI220012 AW515620 AL535989 AU132566 AW468097 AL700223 AI271348 AK024296 AK056913 BM315089 CF144682 AL700154 AI568973 AW001886
GeneLoc Exon Structure
|
Expression
for ZBTB10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBTB10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTCGAGGG
About this image
See ZBTB10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBTB10
SOURCE GeneReport for Unigene cluster: Hs.591868
SABiosciences Custom PCR Arrays for ZBTB10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB10 |
Orthologs
for ZBTB10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZBTB10 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for ZBTB10 (if available)
TreeFam Gene Tree for ZBTB10 (if available) |
Paralogs
for ZBTB10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBTB10 gene
- ZBTB32 ZBTB182 ZBTB8A2 ZBTB442 ZBTB52 ENSG000002545532 HIC12 ZBTB492
- ZBTB242 GZF12 ZBTB422 HIC22 MYNN2 ZBTB462 ZBTB8B2 ZBTB172
18/31 SIMAP similar genes for ZBTB10 using alignment to 3 protein entries: ZBT10_HUMAN (see all proteins)
(see all similar genes):ZBTB20 ZBTB3 ZBTB7C BACH2 ZBTB4 ZBTB49
ZNF295 ZNF131 KLHL2 MYNN ZBTB21 ZBTB38
ZBTB1 ZBTB25 HIC1 KLHL18 KLHL32 ZBTB22
ZBTB10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZBTB10
PGOHUM00000250532
|
Genomic Variants
for ZBTB10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBTB10 (81397854 - 81438500 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBTB10: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB10 |
|
Disorders
/ Diseases
for ZBTB10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBTB10 for disorders About GeneDecksing
1  disease for ZBTB10: About MalaCardsbreast cancer
Export disorders for ZBTB10 gene to outside databases
|
Publications
for ZBTB10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBTB10 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with ZBTB10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Meta-analysis of genome-wide association studies ident ifies three new risk loci for atopic dermatitis. (PubMed id 22197932)1 Paternoster L....Weidinger S. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid ho rmone regulation. (PubMed id 22829776)1 Coviello A.D....Perry J.R. (2012)
- Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for ZBTB10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZBTB10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBTB10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBTB10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBTB10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZBTB10 gene:
Search GeneIP for patents involving ZBTB10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBTB10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZBTB10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBTB10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBTB10 | | | OriGene Protein Over-expression Lysate for ZBTB10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZBTB10 | | OriGene 3'-UTR Clone for ZBTB10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBTB10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ZBTB10 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBTB10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB10 |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB10 |
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