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Aliases for ZBTB10 Gene

Aliases for ZBTB10 Gene

  • Zinc Finger And BTB Domain Containing 10 2 3 5
  • Zinc Finger Protein RIN ZF 3 4
  • RINZF 3 4
  • Zinc Finger Protein RINZF 3
  • RINZFC 4

External Ids for ZBTB10 Gene

Previous GeneCards Identifiers for ZBTB10 Gene

  • GC08P081447
  • GC08P081448
  • GC08P081561
  • GC08P076888

Summaries for ZBTB10 Gene

GeneCards Summary for ZBTB10 Gene

ZBTB10 (Zinc Finger And BTB Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for ZBTB10 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB10 Gene

Genomics for ZBTB10 Gene

Regulatory Elements for ZBTB10 Gene

Promoters for ZBTB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBTB10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBTB10 Gene

Chromosome:
8
Start:
80,485,619 bp from pter
End:
80,526,265 bp from pter
Size:
40,647 bases
Orientation:
Plus strand

Genomic View for ZBTB10 Gene

Genes around ZBTB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBTB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBTB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB10 Gene

Proteins for ZBTB10 Gene

  • Protein details for ZBTB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DT7-ZBT10_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 10
    Protein Accession:
    Q96DT7
    Secondary Accessions:
    • A4FVD0
    • Q86W96
    • Q8IXI9
    • Q96MH9

    Protein attributes for ZBTB10 Gene

    Size:
    871 amino acids
    Molecular mass:
    94894 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZBTB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB10 Gene

Proteomics data for ZBTB10 Gene at MOPED

Post-translational modifications for ZBTB10 Gene

  • Ubiquitination at Lys 460
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBTB10 Gene

Antibody Products

No data available for DME Specific Peptides for ZBTB10 Gene

Domains & Families for ZBTB10 Gene

Gene Families for ZBTB10 Gene

Suggested Antigen Peptide Sequences for ZBTB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DT7

UniProtKB/Swiss-Prot:

ZBT10_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZBTB10: view

Function for ZBTB10 Gene

Molecular function for ZBTB10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZBTB10 Gene

genes like me logo Genes that share phenotypes with ZBTB10: view

Animal Model Products

CRISPR Products

miRNA for ZBTB10 Gene

miRTarBase miRNAs that target ZBTB10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBTB10 Gene

Localization for ZBTB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB10 Gene COMPARTMENTS Subcellular localization image for ZBTB10 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZBTB10 Gene

Pathways & Interactions for ZBTB10 Gene

SuperPathways for ZBTB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBTB10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBTB10 Gene

Drugs & Compounds for ZBTB10 Gene

No Compound Related Data Available

Transcripts for ZBTB10 Gene

Unigene Clusters for ZBTB10 Gene

Zinc finger and BTB domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB10 Gene

No ASD Table

Relevant External Links for ZBTB10 Gene

GeneLoc Exon Structure for
ZBTB10
ECgene alternative splicing isoforms for
ZBTB10

Expression for ZBTB10 Gene

mRNA expression in normal human tissues for ZBTB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBTB10 Gene

This gene is overexpressed in Bone (34.4), Heart (21.7), Liver (6.6), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBTB10 Gene



SOURCE GeneReport for Unigene cluster for ZBTB10 Gene Hs.591868

genes like me logo Genes that share expression patterns with ZBTB10: view

Protein tissue co-expression partners for ZBTB10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB10 Gene

Orthologs for ZBTB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB10 35
  • 99.65 (n)
  • 99.53 (a)
ZBTB10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB10 36
  • 93 (a)
OneToOne
ZBTB10 35
  • 94.71 (n)
  • 95.25 (a)
dog
(Canis familiaris)
Mammalia ZBTB10 35
  • 95 (n)
  • 96.96 (a)
ZBTB10 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb10 36
  • 89 (a)
OneToOne
Zbtb10 35
  • 89.29 (n)
  • 88.49 (a)
Zbtb10 16
oppossum
(Monodelphis domestica)
Mammalia ZBTB10 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB10 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb10 35
  • 90.71 (n)
  • 90.5 (a)
chicken
(Gallus gallus)
Aves ZBTB10 35
  • 79.72 (n)
  • 79.83 (a)
ZBTB10 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.915 35
zbtb10 35
  • 70.3 (n)
  • 65.52 (a)
zebrafish
(Danio rerio)
Actinopterygii zbtb10 36
  • 56 (a)
OneToOne
zbtb10 35
  • 61.74 (n)
  • 61.42 (a)
Species with no ortholog for ZBTB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB10 Gene

ENSEMBL:
Gene Tree for ZBTB10 (if available)
TreeFam:
Gene Tree for ZBTB10 (if available)

Paralogs for ZBTB10 Gene

(9) SIMAP similar genes for ZBTB10 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZBTB10 Gene

genes like me logo Genes that share paralogs with ZBTB10: view

Variants for ZBTB10 Gene

Sequence variations from dbSNP and Humsavar for ZBTB10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_018384 -
VAR_018385 -
rs272614 -- 80,526,751(-) AAAAC(A/G)TATAA downstream-variant-500B
rs446001 -- 80,516,482(+) TTAGA(A/G)ATGTG intron-variant
rs408925 -- 80,522,051(-) AAAAT(C/G)TGTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZBTB10 Gene

Variant ID Type Subtype PubMed ID
esv272175 CNV Insertion 20981092
esv269293 CNV Insertion 20981092

Variation tolerance for ZBTB10 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.93; 74.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBTB10 Gene

HapMap Linkage Disequilibrium report
ZBTB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB10 Gene

Disorders for ZBTB10 Gene

Relevant External Links for ZBTB10

Genetic Association Database (GAD)
ZBTB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBTB10

No disorders were found for ZBTB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBTB10 Gene

Publications for ZBTB10 Gene

  1. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N. … Do C.B. (PLoS ONE 2012) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for ZBTB10 Gene

Sources for ZBTB10 Gene

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