Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBTB1 Gene

protein-coding   GIFtS: 51
GCID: GC14P064971

Zinc Finger And BTB Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger And BTB Domain Containing 11 2
ZNF9092
Zinc Finger And BTB Domain-Containing Protein 12
KIAA09973

External Ids:    HGNC: 202591   Entrez Gene: 228902   Ensembl: ENSG000001268047   UniProtKB: Q9Y2K13   

Export aliases for ZBTB1 gene to outside databases

Previous GC identifers: GC14P058765 GC14P062961 GC14P062960 GC14P064040 GC14P045143


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZBTB1 Gene: 
ZBTB1 (zinc finger and BTB domain containing 1) is a protein-coding gene. Diseases associated with ZBTB1 include t cell deficiency, and lung cancer. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZBTB2.

UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBTB1 gene promoter:
         E2F-3a   E2F-5   E2F-1   E2F   E2F-2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZBTB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBTB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.3

ZBTB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P064971:  view genomic region     (about GC identifiers)

Start:
64,970,430 bp from pter      End:
65,000,408 bp from pter
Size:
29,979 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 1  
Size: 713 amino acids; 82016 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA76841.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6S8 Q86SW8
Alternative splicing: 2 isoforms:  Q9Y2K1-1   Q9Y2K1-2   

Explore the universe of human proteins at neXtProt for ZBTB1: NX_Q9Y2K1

Explore proteomics data for ZBTB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2K1

  • ZBTB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBTB1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116801.1  NP_055765.2  

    ENSEMBL proteins: 
     ENSP00000451584   ENSP00000450689   ENSP00000451000   ENSP00000351587   ENSP00000451332  
     ENSP00000378201  

    Human Recombinant Protein Products for ZBTB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ZBTB1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZBTB1
    GenScript Custom Purified and Recombinant Proteins Services for ZBTB1
    Novus Biologicals ZBTB1 Protein
    Novus Biologicals ZBTB1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZBTB1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    ZBTB1 for ontologies           About GeneDecksing



    ZBTB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ZBTB1
    OriGene Custom Antibody Services for ZBTB1
    GenScript Custom Superior Antibodies Services for ZBTB1
    Novus Biologicals ZBTB1 Antibodies
    Abcam antibodies for ZBTB1
    Cloud-Clone Corp. Antibodies for ZBTB1 
    ThermoFisher Antibodies for ZBTB1
    LSBio Antibodies in human, mouse, rat for ZBTB1 

    Assay Products for ZBTB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZBTB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZBTB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZBTB1 
    Cloud-Clone Corp. CLIAs for ZBTB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    5/6 InterPro protein domains (see all 6):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q9Y2K1

    ProtoNet protein and cluster: Q9Y2K1

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 8 C2H2-type zinc fingers


    ZBTB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBTB1_HUMAN, Q9Y2K1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0042803protein homodimerization activity IDA--
    GO:0046872metal ion binding IEA--
         
    ZBTB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB1:
     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zbtb1):
     cellular  hematopoietic system  immune system 

    ZBTB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZBTB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBTB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZBTB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB1:
    hsa-miR-374a* hsa-miR-9 hsa-miR-3658 hsa-miR-376a* hsa-miR-3909 hsa-miR-138-2* hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidZBTB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZBTB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZBTB1
    Sirion Biotech Customized adenovirus for overexpression of ZBTB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZBTB1 (see all 11)
    OriGene ORF clones in mouse, rat for ZBTB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZBTB1 (NM_006006)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB1
    Sirion Biotech Customized lentivirus for stable overexpression of ZBTB1 
                         Customized lentivirus expression plasmids for stable overexpression of ZBTB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZBTB1
    Search LifeMap BioReagents cell lines for ZBTB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBTB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for ZBTB1 (Q9Y2K12, 3 ENSP000003782014) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    ZBTB25P242783, ENSP000002616834I2D: score=1 STRING: ENSP00000261683
    EWSR1Q018443, ENSP000003810314I2D: score=1 STRING: ENSP00000381031
    LZTR1Q8N6533, ENSP000002157394I2D: score=1 STRING: ENSP00000215739
    MAML3Q96JK93I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0002711positive regulation of T cell mediated immunity ISS--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0030183B cell differentiation IEA--

    ZBTB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBTB1

    Search CenterWatch for drugs/clinical trials and news about ZBTB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBTB1 gene (2 alternative transcripts): 
    NM_001123329.1  NM_014950.2  

    Unigene Cluster for ZBTB1:

    Zinc finger and BTB domain containing 1
    Hs.605143  [show with all ESTs]
    Unigene Representative Sequence: NM_014950
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556818 ENST00000553583 ENST00000556965 ENST00000554015 ENST00000358738(uc001xhi.2)
    ENST00000555321 ENST00000394712(uc001xhh.4 uc010aqg.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZBTB1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ZBTB1:
    hsa-miR-374a* hsa-miR-9 hsa-miR-3658 hsa-miR-376a* hsa-miR-3909 hsa-miR-138-2* hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidZBTB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZBTB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB1
    Clone
    Products:
         
    OriGene clones in human, mouse for ZBTB1 (see all 11)
    OriGene ORF clones in mouse, rat for ZBTB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ZBTB1 (NM_006006)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZBTB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB1
    Sirion Biotech Customized lentivirus for stable overexpression of ZBTB1 
                         Customized lentivirus expression plasmids for stable overexpression of ZBTB1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB1

    Additional mRNA sequence: 

    AB023214.1 AK055910.1 AK291743.1 AY598321.1 BC050719.1 BX248777.1 BX537646.1 

    12 DOTS entries:

    DT.75104387  DT.100755516  DT.120751930  DT.100722950  DT.100767402  DT.40209766  DT.40283744  DT.120751962 
    DT.100755518  DT.120751929  DT.120752025  DT.40208076 

    24/132 AceView cDNA sequences (see all 132):

    CK820532 BQ083854 CD723785 AY598321 AB023214 BE676821 AA972454 C00825 
    AI051763 BI711256 AI684826 AW170790 CA407302 AA309699 BU187083 BM459450 
    AA805608 CA416922 CA445399 AI073955 AW575798 BU628049 BU742341 BX248777 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
    SP1:                    -     -                 -     -                                 
    SP2:                                            -                                       
    SP3:                                                                                    
    SP4:              -     -     -     -     -     -     -                                 
    SP5:                                      -     -     -                                 


    ECgene alternative splicing isoforms for ZBTB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBTB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZBTB1 Expression
    About this image


    See ZBTB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBTB1

    SOURCE GeneReport for Unigene cluster: Hs.605143
        SABiosciences Custom PCR Arrays for ZBTB1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBTB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb11 , 5 zinc finger and BTB domain containing 11, 5 89.33(n)1
    95.22(a)1
      12 (33.73 cM)5
    2685641  NM_178744.21  NP_848859.11 
     763702665 
    chicken
    (Gallus gallus)
    Aves ZBTB11 zinc finger and BTB domain containing 1 77.42(n)
    80.14(a)
      428916  XM_001234834.2  XP_001234835.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB16
    Uncharacterized protein
    73(a)
    1 ↔ 1
    1(1397145-1399271)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.85072 Xenopus laevis transcribed sequence with weak similarity more 75.85(n)    BQ384255.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.260612 Transcribed sequence with moderate similarity to protein more 79.05(n)    CD604081.1 


    ENSEMBL Gene Tree for ZBTB1 (if available)
    TreeFam Gene Tree for ZBTB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZBTB1 gene
    ZBTB22  ZBTB252  
    18/26 SIMAP similar genes for ZBTB1 using alignment to 4 protein entries:     ZBTB1_HUMAN (see all proteins) (see all similar genes):
    ZBTB7C    ZBTB25    BACH2    ZBTB4    HIC1    MYNN
    ZBTB3    ZBTB38    KLHL32    NACC1    ZNF131    ZBTB14
    ZBTB49    KLHL2    ZBTB21    ZBTB44    KLHL24    BACH1

    ZBTB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/541 SNPs in ZBTB1 are shown (see all 541)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783249471,2
    F--64972621(+) CTCGAA/GCCCAA 2 -- int11Minor allele frequency- G:0.05WA 118
    rs2009066451,2
    C--64972952(+) CCTCT-/AAAG  
            
    AAGAA
    2 -- int10--------
    rs118517511,2
    C,F,H--64973016(+) gaggcT/Cgaggc 2 -- int12Minor allele frequency- C:0.00NA CSA 3
    rs740564401,2
    C--64973421(+) CATGGT/CATTGA 2 -- int12Minor allele frequency- C:0.07WA 120
    rs1814100881,2
    --64973428(+) TTGAAA/TAACTC 2 -- int10--------
    rs740564411,2
    C--64973701(+) GTTCAT/CCGACC 2 -- int13Minor allele frequency- C:0.05WA EA 240
    rs1121356981,2
    C,F--64973924(+) GGTATG/ATTTGA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1414342831,2
    --64974025(+) AAATTA/GTTTTT 2 -- int10--------
    rs740564431,2
    C,F--64974052(+) GAACCA/GAATTA 2 -- int12Minor allele frequency- G:0.09WA 120
    rs1127411571,2
    C,F--64974067(+) TTACTG/CGTGTC 2 -- int11Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for ZBTB1 (64970430 - 65000408 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZBTB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748779CNV Deletion23290073
    nsv521823CNV Loss19592680
    nsv826966CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBTB1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBTB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZBTB1:    About MalaCards
    t cell deficiency    lung cancer

    1 disease from the University of Copenhagen DISEASES database for ZBTB1:
    T cell deficiency

    ZBTB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZBTB1

    Export disorders for ZBTB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBTB1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ZBTB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    4. Novel human BTB/POZ domain-containing zinc finger prot ein ZBTB1 inhibits transcriptional activities of CRE. (PubMed id 21706167)1 Liu Q....Wang J.C. (2011)
    5. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. Site-specific identification of SUMO-2 targets in cel ls reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. (PubMed id 20797634)1 Matic I....Vertegaal A.C. (2010)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    9. Functional screening of FxxLF-like peptide motifs ide ntifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. (PubMed id 19762545)1 van de Wijngaart D.J....Jenster G. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22890 HGNC: 20259 AceView: ZBTB1 Ensembl:ENSG00000126804 euGenes: HUgn22890
    ECgene: ZBTB1 H-InvDB: ZBTB1

    (According to HUGE)
    About This Section
    HUGE: KIAA0997

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBTB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBTB1 gene:
    Search GeneIP for patents involving ZBTB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ZBTB1   OriGene RNAi products in human, mouse, rat for ZBTB1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ZBTB1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZBTB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZBTB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZBTB1   OriGene Custom Protein Services for ZBTB1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBTB1
     QIAGEN SeqTarget long-range PCR primers for resequencing ZBTB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBTB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBTB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBTB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBTB1
     GenScript Custom Purified and Recombinant Proteins Services for ZBTB1 GenScript cDNA clones with any tag delivered in your preferred vector for ZBTB1
     GenScript Custom Assay Services for ZBTB1 GenScript Custom Superior Antibodies Services for ZBTB1
     GenScript Custom overexpressing Cell Line Services for ZBTB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZBTB1 promoter
     Search Chromatin IP Primers for ZBTB1
     RT2 qPCR Primer Assay in human, mouse, rat ZBTB1
     Search GNC Networks for ZBTB1
     SABiosciences Custom PCR Arrays for ZBTB1
     Search Tocris compounds for ZBTB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZBTB1 antibodies
     ZBTB1 proteins
     ZBTB1 lysates
     Antibodies for ZBTB1
     See all of Abcam's Antibodies, Kits and Proteins for ZBTB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZBTB1
     Antibodies for ZBTB1
     ELISAs for ZBTB1
     CLIAs for ZBTB1
     Search LifeMap BioReagents cell lines for ZBTB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBTB1
     SwitchGear 3'UTR luciferase reporter plasmids for ZBTB1
     SwitchGear Promoter luciferase reporter plasmids for ZBTB1
     ThermoFisher Antibodies for ZBTB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBTB1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBTB1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZBTB1
    Customized:
     lentivirus for stable overexpression of ZBTB1
     lentivirus expression plasmids for stable overexpression of ZBTB1
     adenovirus for overexpression of ZBTB1
     LSBio Antibodies in human, mouse, rat for ZBTB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZBTB1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4