V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

ZBTB1 Gene

protein-coding   GIFtS: 50

GC14P064040
zinc finger and BTB domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for ZBTB1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
KIAA0997 1, 2, 3
Descriptions
zinc finger and BTB domain containing 1 2
External Ids
HGNC: 202591
Entrez Gene: 228902
UniProtKB: Q9Y2K13
Ensembl: ENSG000001268047
Search outside databases for aliases for ZBTB1 gene

Previous GC identifers: GC14P058765 GC14P062961 GC14P062960

Summaries
for ZBTB1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1
Function: May be involved in transcriptional regulation

Genomic Location
for ZBTB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBTB1 gene  

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.2

ZBTB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P064040:     (about GC identifiers)

Start:
 64,040,456 bp from pter
End:
 64,070,161 bp from pter
Size:
 29,706 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  

Proteins
for ZBTB1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 1  
Size: 713 amino acids; 82016 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A8K6S8 Q86SW8

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001116801.1  NP_055765.2  


    ENSEMBL proteins: 
    ENSP00000378201 ENSP00000351587 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ZBTB1)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for ZBTB1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ZBTB1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ZBTB1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for ZBTB1

    Assays for ZBTB1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for ZBTB1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ


       GeneDecks  ZBTB1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y2K1

    ProtoNet protein and cluster: Q9Y2K1

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 8 C2H2-type zinc fingers

    Gene Function
    for ZBTB1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZBTB1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014950

                  Applied Biosystems Silencer® siRNAs for ZBTB1

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB1  
                         Sigma-Aldrich shRNA for ZBTB1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ZBTB1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001123329
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001123329
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001123329 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001123329

    UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1
    Function: May be involved in transcriptional regulation

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for ZBTB1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for ZBTB1 (Q9Y2K12) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --Q9WMX22MINT-7047775
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table

    Drugs & Compounds
    for ZBTB1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ZBTB1

    Transcripts
    for ZBTB1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (ZBTB1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ZBTB1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014950

                  Sigma-Aldrich siRNA and siRNA Panels for ZBTB1  
                         Sigma-Aldrich shRNA for ZBTB1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001123329  NM_014950  

    REFSEQ mRNAs for ZBTB1 gene (2 alternative transcripts): 

    NM_001123329.1   NM_014950.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001123329  NM_014950  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001123329
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001123329
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001123329 

    Additional cDNA sequence: 

    AB023214.1 AK055910.1 AK291743.1 AY598321.1 BC050719.1 BX248777.1 BX537646.1 

    12 DOTS entries:

    DT.75104387  DT.100755516  DT.120751930  DT.100722950  DT.100767402  DT.120751929  DT.40209766  DT.40283744 
    DT.120751962  DT.40208076  DT.100755518  DT.120752025 

    24/132 AceView cDNA sequences (see all 132 ):

    CA454136 C00825 AA309699 BQ083854 BU742341 CA407302 BQ722524 AY598321 
    AI684826 AW170790 BI711256 BU187083 CA416922 CK820532 BC050719 AW575798 
    AI143997 BE676821 BQ214005 BX248777 AI073955 CK825265 AA805608 AI051763 

    highest scoring ESTs for ZBTB1:

    AB023214 AA309699 AA318600 AA715296 AA730702 AA768115 AI557317 AI962913 AU252796 AW962139 

    Unigene Cluster for ZBTB1:

    Zinc finger and BTB domain containing 1
    Hs.655536  [show with all ESTs]
    Unigene Representative Sequence: NM_014950


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB1

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
    SP1:                    -     -                 -     -                                 
    SP2:                                            -                                       
    SP3:                                                                                    
    SP4:              -     -     -     -     -     -     -                                 
    SP5:                                      -     -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for ZBTB1

    2 Ensembl transcripts including schematic representations:
    ENST00000394712  ENST00000358738  

    Expression
    for ZBTB1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ZBTB1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ZBTB1

    1 / 2 / 3

    6 probe-sets matching ZBTB1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		34750_r_at2, 3 U95-A 1 1.00 1.00 0.40 0.41 AB023214 1.00 1.00 1.00 1
    34751_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 AI970189 0.60 1.00 0.82 1

    		213376_at2, 3 U133-A 1 1.00 1.00 -- -- AI656706 0.60 1.00 0.82 1

    		205092_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014950 0.60 1.00 0.82 1

    		213376_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		205092_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ZBTB1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.655536

    Expression variation in blood from EXPOLDB for ZBTB1

    Orthologs
    for ZBTB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for ZBTB1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ZBTB11   -- zinc finger and BTB domain containing 1 93.59(n)
    96.55(a)    		 490731  XM_861136.1  XP_866229.1 
    chimpanzee
    (Pan troglodytes)    		 ZBTB11   -- zinc finger and BTB domain containing 1 99.79(n)
    99.84(a)    		 467482  XM_522879.2  XP_522879.1 
    cow
    (Bos taurus)    		 ZBTB11   -- zinc finger and BTB domain containing 1 93.69(n)
    97.52(a)    		 526903  XM_865201.2  XP_870294.2 
    rat
    (Rattus norvegicus)    		 Zbtb11   -- zinc finger and BTB domain containing 1 84.47(n)
    92.23(a)    		 314246  NM_001004444.1  NP_001004444.1 
    mouse
    (Mus musculus)    		 Zbtb11, 5 125
    		 zinc finger and BTB domain containing 11, 5 88.8(n)1
    94.61(a)1    		 2685641  NM_178744.11  NP_848859.11 
     AA1686585  AI2563695  (see all 14)
    About this table        Species with no ortholog for ZBTB1

    ENSEMBL Gene Tree for ZBTB1

    Paralogs
    for ZBTB1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ZBTB1 gene
    ZBTB22  ZBTB252  

    SNPs/Variants
    for ZBTB1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/148 NCBI SNPs in ZBTB1 are shown (see all 148 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 58)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs15423131,2
    		A,C,F,H,O64069791(+) AGTTAC/ATCTCT 1 -- ut3119Minor allele frequency- A:0.49NA EA MN EU WA 1560
    rs123859181,2
    		A,C,F,H64069698(+) CCACTG/AAAGGG 1 -- ut31 ese38Minor allele frequency- A:0.16EU EA WA 748
    rs123859101,2
    		A,C,F,H64069723(+) AATTCT/AACTGC 1 -- ut31 ese311Minor allele frequency- A:0.19EU EA WA NA 974
    rs108911,2
    		C,F64060379(+) ACAAGT/CGGTTG 2 -- ut31 int11Minor allele frequency- C:0.04MN 184
    rs101334111,2
    		A,C,F,H64058677(+) GAGCAT/CGTGCT 2 H/H syn18Minor allele frequency- C:0.17EU EA WA 836
    rs14530091,2
    		A,C,F,H,O64065447(+) ATAAAG/ACTCCT 1 -- int117Minor allele frequency- A:0.20MN EU EA WA NA 1600
    rs9268031,2
    		A,C,F,H,O64047492(-) ACCTAT/GAACTT 1 -- int121Minor allele frequency- G:0.26EA NA EU WA 1728
    rs14530071,2
    		A,C,F,H,O64043956(+) TCACCA/GTGTAC 1 -- int113Minor allele frequency- G:0.22MN EU EA WA NA 1236
    --
    rs101324241,2
    		A,C,F,H64063628(+) TAATTT/AAAAAA 1 -- int14Minor allele frequency- A:0.17EU EA WA 418
    rs14530041,2
    		A,C,F,H64066708(+) GATTCT/CGTGGA 1 -- int18Minor allele frequency- C:0.17EU EA WA 838
    About this table

    HapMap Linkage Disequilibrium images for ZBTB1 (up to first 250kb)

    Disorders & Mutations
    for ZBTB1

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		   --

    Medical News
    for ZBTB1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for ZBTB1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		9 PubMed articles for ZBTB1 gene:

    Search for ZBTB1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZBTB1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 22890 HGNC: 20259 AceView: ZBTB1 Ensembl:ENSG00000126804 euGenes: HUgn22890
    ECgene: ZBTB1 H-InvDB: ZBTB1

    Other Databases showing ZBTB1

    (According to HUGE)
    About This Section
    HUGE: KIAA0997

    Specialized Databases showing ZBTB1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for ZBTB1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for ZBTB1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ZBTB1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBTB1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ZBTB1 Antibodies for ZBTB1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ZBTB1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Chimera RNAi (ZBTB1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (ZBTB1)
     Antibodies (ZBTB1)
     Search OriGene for ZBTB1
     Search Tocris compounds for ZBTB1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for ZBTB1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    ZBTB1 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com