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ZBTB1 Gene

protein-coding   GIFtS: 52
GCID: GC14P064971

Zinc Finger And BTB Domain Containing 1

  See ZBTB1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger And BTB Domain Containing 11 2     PLZF5
ZNF9092     ZBTB165
Zinc Finger And BTB Domain-Containing Protein 12     ZNF1455
KIAA09973     

External Ids:    HGNC: 202591   Entrez Gene: 228902   Ensembl: ENSG000001268047   OMIM: 1767975   UniProtKB: Q9Y2K13   

Export aliases for ZBTB1 gene to outside databases

Previous GC identifers: GC14P058765 GC14P062961 GC14P062960 GC14P064040 GC14P045143


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBTB1 Gene:
ZBTB1 (zinc finger and BTB domain containing 1) is a protein-coding gene. Diseases associated with ZBTB1 include t cell deficiency. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is ZBTB2.

UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1
Function: Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional
activation. Involved in lymphoid lineage commitment and differentiation. Plays a key role in the instruction of
early lymphoid progenitors to develop into T-cell lineage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBTB1 gene promoter:
         E2F-3a   E2F-5   E2F-1   E2F   E2F-2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZBTB1 promoter sequence
   Search Chromatin IP Primers for ZBTB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBTB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23.3

ZBTB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBTB1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P064971:  view genomic region     (about GC identifiers)

Start:
64,970,430 bp from pter      End:
65,000,408 bp from pter
Size:
29,979 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1 (See protein sequence)
Recommended Name: Zinc finger and BTB domain-containing protein 1  
Size: 713 amino acids; 82016 Da
Subunit: Homodimer. Homooligomer. Isoform 1 and isoform 2 can homodimerize. Heterodimer of isoform 1 and isoform 2
Sequence caution: Sequence=BAA76841.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6S8 Q86SW8
Alternative splicing: 2 isoforms:  Q9Y2K1-1   Q9Y2K1-2   

Explore the universe of human proteins at neXtProt for ZBTB1: NX_Q9Y2K1

Explore proteomics data for ZBTB1 at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional
    repression activity and regulates its subcellular localization1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBTB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116801.1  NP_055765.2  

    ENSEMBL proteins: 
     ENSP00000451584   ENSP00000450689   ENSP00000451000   ENSP00000351587   ENSP00000451332  
     ENSP00000378201  

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    Cloud-Clone Corp. Proteins for ZBTB1

     
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    antibodies-online proteins for ZBTB1 (3 products) 

     
    antibodies-online peptides for ZBTB1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9Y2K1

    ProtoNet protein and cluster: Q9Y2K1

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: ZBTB1_HUMAN, Q9Y2K1
    Domain: Both the BTB domain and C2H2-type motifs are necessary for transriptional repression activity. The BTB
    domain is also necessary for oligomerization and efficient sumoylation. The hydrophobic cluster preceding Lys-328
    enhanced sumoylation efficiency (PubMed:20797634)
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 8 C2H2-type zinc fingers


    Find genes that share domains with ZBTB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBTB1_HUMAN, Q9Y2K1
    Function: Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional
    activation. Involved in lymphoid lineage commitment and differentiation. Plays a key role in the instruction of
    early lymphoid progenitors to develop into T-cell lineage

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IDA--
    GO:0046872metal ion binding IEA--
    GO:0046982protein heterodimerization activity IDA--
         
    Find genes that share ontologies with ZBTB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBTB1:
     Increased G1 DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Zbtb1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with ZBTB1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZBTB1

    miRNA
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    miRTarBase miRNAs that target ZBTB1:
    hsa-mir-335-5p (MIRT017131)

    Block miRNA regulation of human, mouse, rat ZBTB1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ZBTB1:
    hsa-miR-374a* hsa-miR-9 hsa-miR-3658 hsa-miR-376a* hsa-miR-3909 hsa-miR-138-2* hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidZBTB1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBTB1_HUMAN, Q9Y2K1: Nucleus. Nucleus, nucleoplasm. Note=Localized in dot-like structures in the nucleus.
    Colocalized with SMRT in nuclear bodies. The sumoylated form is preferentially located in the nucleoplasm outside
    the nuclear bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA--
    GO:0016604nuclear body IDA--

    Find genes that share ontologies with ZBTB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBTB1
    Interactions:

        Search GeneGlobe Interaction Network for ZBTB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ZBTB1 (Q9Y2K12, 3 ENSP000003782014) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    EWSR1Q018443, ENSP000003810314I2D: score=1 STRING: ENSP00000381031
    LZTR1Q8N6533, ENSP000002157394I2D: score=1 STRING: ENSP00000215739
    MAML3Q96JK93I2D: score=1 
    MDM2Q009873I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0002711positive regulation of T cell mediated immunity ISS--
    GO:0030183B cell differentiation IEA--
    GO:0032825positive regulation of natural killer cell differentiation ISS--
    GO:0033077T cell differentiation in thymus IEA--

    Find genes that share ontologies with ZBTB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBTB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBTB1 gene (2 alternative transcripts): 
    NM_001123329.1  NM_014950.2  

    Unigene Cluster for ZBTB1:

    Zinc finger and BTB domain containing 1
    Hs.605143  [show with all ESTs]
    Unigene Representative Sequence: NM_014950
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556818 ENST00000553583 ENST00000556965 ENST00000554015 ENST00000358738(uc001xhi.2)
    ENST00000555321 ENST00000394712(uc001xhh.4 uc010aqg.3)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ZBTB1:
    hsa-miR-374a* hsa-miR-9 hsa-miR-3658 hsa-miR-376a* hsa-miR-3909 hsa-miR-138-2* hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidZBTB1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZBTB1
      QuantiFast Probe-based Assays in human, mouse, rat ZBTB1

    Additional mRNA sequence: 

    AB023214.1 AK055910.1 AK291743.1 AY598321.1 BC050719.1 BX248777.1 BX537646.1 

    12 DOTS entries:

    DT.75104387  DT.100755516  DT.120751930  DT.100722950  DT.100767402  DT.40209766  DT.40283744  DT.120751962 
    DT.100755518  DT.120751929  DT.120752025  DT.40208076 

    Selected AceView cDNA sequences (see all 132):

    BE676821 BX248777 AI684826 AY598321 CA416922 BQ083854 CD723785 BM975910 
    AA972454 AI143997 CK820532 AI051763 CA445399 AW170790 BQ722524 BM459450 
    AI073955 BU742341 CK825265 AW575798 AB023214 CA454136 CA407302 BC050719 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
    SP1:                    -     -                 -     -                                 
    SP2:                                            -                                       
    SP3:                                                                                    
    SP4:              -     -     -     -     -     -     -                                 
    SP5:                                      -     -     -                                 


    ECgene alternative splicing isoforms for ZBTB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBTB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZBTB1 Expression
    About this image

    ZBTB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBTB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.605143
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZBTB1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbtb11 , 5 zinc finger and BTB domain containing 11, 5 89.33(n)1
    95.22(a)1
      12 (33.73 cM)5
    2685641  NM_178744.21  NP_848859.11 
     763702665 
    chicken
    (Gallus gallus)
    Aves ZBTB11 zinc finger and BTB domain containing 1 80.44(n)
    83.9(a)
      428916  XM_004936425.1  XP_004936482.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBTB16
    zinc finger and BTB domain containing 1
    73(a)
    1 ↔ 1
    1(1397145-1399271)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.85072 Xenopus laevis transcribed sequence with weak similarity more 75.85(n)    BQ384255.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.260612 Transcribed sequence with moderate similarity to protein more 79.05(n)    CD604081.1 


    ENSEMBL Gene Tree for ZBTB1 (if available)
    TreeFam Gene Tree for ZBTB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBTB1 gene
    ZBTB22  ZBTB252  
    Selected SIMAP similar genes for ZBTB1 using alignment to 4 protein entries:     ZBTB1_HUMAN (see all proteins) (see all similar genes):
    ZBTB7C    ZBTB25    BACH2    ZBTB4    HIC1    MYNN
    ZBTB3    ZBTB38    KLHL32    NACC1    ZNF131    ZBTB14
    ZBTB49    KLHL2    ZBTB21    ZBTB44    KLHL24    BACH1

    Find genes that share paralogs with ZBTB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBTB1 (see all 541)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783249471,2
    F--64972621(+) CTCGAA/GCCCAA 2 -- int11Minor allele frequency- G:0.05WA 118
    rs2009066451,2
    C--64972952(+) CCTCT-/AAAG  
            
    AAGAA
    2 -- int10--------
    rs118517511,2
    C,F,H--64973016(+) gaggcT/Cgaggc 2 -- int12Minor allele frequency- C:0.00NA CSA 3
    rs740564401,2
    C--64973421(+) CATGGT/CATTGA 2 -- int12Minor allele frequency- C:0.07WA 120
    rs1814100881,2
    --64973428(+) TTGAAA/TAACTC 2 -- int10--------
    rs740564411,2
    C--64973701(+) GTTCAT/CCGACC 2 -- int13Minor allele frequency- C:0.05WA EA 240
    rs1121356981,2
    C,F--64973924(+) GGTATG/ATTTGA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1414342831,2
    --64974025(+) AAATTA/GTTTTT 2 -- int10--------
    rs740564431,2
    C,F--64974052(+) GAACCA/GAATTA 2 -- int12Minor allele frequency- G:0.09WA 120
    rs1127411571,2
    C,F--64974067(+) TTACTG/CGTGTC 2 -- int11Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for ZBTB1 (64970430 - 65000408 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZBTB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748779CNV Deletion23290073
    nsv521823CNV Loss19592680
    nsv826966CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176797   
    OMIM disorders: 612447  
    1 disease for ZBTB1:    
    About MalaCards
    t cell deficiency

    1 disease from the University of Copenhagen DISEASES database for ZBTB1:
    T cell deficiency

    Find genes that share disorders with ZBTB1           About GenesLikeMe

    Genetic Association Database (GAD): ZBTB1

    Export disorders for ZBTB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBTB1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ZBTB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE. (PubMed id 21706167)1, 2 Liu Q....Wang J.C. (Mol. Cell. Biochem. 2011)
    3. Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. (PubMed id 20797634)1, 2 Matic I....Vertegaal A.C. (Mol. Cell 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development. (PubMed id 22753936)2 Punwani D.... Puck J.M. (J. Immunol. 2012)
    7. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    10. Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. (PubMed id 19762545)1 van de Wijngaart D.J....Jenster G. (Mol. Endocrinol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22890 HGNC: 20259 AceView: ZBTB1 Ensembl:ENSG00000126804 euGenes: HUgn22890
    ECgene: ZBTB1 H-InvDB: ZBTB1

    (According to HUGE)
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    HUGE: KIAA0997

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBTB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZBTB1 gene:
    Search GeneIP for patents involving ZBTB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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