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Aliases for ZBTB1 Gene

Aliases for ZBTB1 Gene

  • Zinc Finger And BTB Domain Containing 1 2 3
  • Zinc Finger And BTB Domain-Containing Protein 1 3
  • KIAA0997 4
  • ZNF145 6
  • ZNF909 3
  • ZBTB16 6
  • PLZF 6

External Ids for ZBTB1 Gene

Summaries for ZBTB1 Gene

GeneCards Summary for ZBTB1 Gene

ZBTB1 (Zinc Finger And BTB Domain Containing 1) is a Protein Coding gene. Diseases associated with ZBTB1 include t cell deficiency. Among its related pathways are Class I MHC mediated antigen processing and presentation and Pathways in cancer. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is ZBTB2.

UniProtKB/Swiss-Prot for ZBTB1 Gene

  • Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. Involved in lymphoid lineage commitment and differentiation. Plays a key role in the instruction of early lymphoid progenitors to develop into T-cell lineage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBTB1 Gene

Genomics for ZBTB1 Gene

Genomic Location for ZBTB1 Gene

Start:
64,503,712 bp from pter
End:
64,533,690 bp from pter
Size:
29,979 bases
Orientation:
Plus strand

Genomic View for ZBTB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBTB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBTB1 Gene

Regulatory Elements for ZBTB1 Gene

Proteins for ZBTB1 Gene

  • Protein details for ZBTB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2K1-ZBTB1_HUMAN
    Recommended name:
    Zinc finger and BTB domain-containing protein 1
    Protein Accession:
    Q9Y2K1
    Secondary Accessions:
    • A8K6S8
    • Q86SW8

    Protein attributes for ZBTB1 Gene

    Size:
    713 amino acids
    Molecular mass:
    82016 Da
    Quaternary structure:
    • Homodimer. Homooligomer. Isoform 1 and isoform 2 can homodimerize. Heterodimer of isoform 1 and isoform 2.
    SequenceCaution:
    • Sequence=BAA76841.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBTB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBTB1 Gene

Proteomics data for ZBTB1 Gene at MOPED

Post-translational modifications for ZBTB1 Gene

  • Sumoylated with SUMO2 at Lys-328 and to a lesser extent at Lys-265. Sumoylation inhibits its transcriptional repression activity and regulates its subcellular localization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBTB1 Gene

No data available for DME Specific Peptides for ZBTB1 Gene

Domains for ZBTB1 Gene

Gene Families for ZBTB1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • BTBD :BTB/POZ domain containing

Protein Domains for ZBTB1 Gene

Suggested Antigen Peptide Sequences for ZBTB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2K1

UniProtKB/Swiss-Prot:

ZBTB1_HUMAN
Domain:
  • Both the BTB domain and C2H2-type motifs are necessary for transcriptional repression activity. The BTB domain is also necessary for oligomerization and efficient sumoylation. The hydrophobic cluster preceding Lys-328 enhanced sumoylation efficiency (PubMed:20797634).:
    • Q9Y2K1
  • Contains 1 BTB (POZ) domain.:
    • Q9Y2K1
Similarity:
  • Contains 8 C2H2-type zinc fingers.:
    • Q9Y2K1
genes like me logo Genes that share domains with ZBTB1: view

Function for ZBTB1 Gene

Molecular function for ZBTB1 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. Involved in lymphoid lineage commitment and differentiation. Plays a key role in the instruction of early lymphoid progenitors to develop into T-cell lineage.

Gene Ontology (GO) - Molecular Function for ZBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IDA 22753936
GO:0046872 metal ion binding IEA --
GO:0046982 protein heterodimerization activity IDA 22753936
genes like me logo Genes that share ontologies with ZBTB1: view

Phenotypes for ZBTB1 Gene

MGI mutant phenotypes for ZBTB1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZBTB1:
genes like me logo Genes that share phenotypes with ZBTB1: view

miRNA for ZBTB1 Gene

miRTarBase miRNAs that target ZBTB1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBTB1 Gene

Localization for ZBTB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBTB1 Gene

Nucleus. Nucleus, nucleoplasm. Note=Localized in dot-like structures in the nucleus. Colocalized with SMRT in nuclear bodies. The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBTB1 Gene COMPARTMENTS Subcellular localization image for ZBTB1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21706167
GO:0005654 nucleoplasm IDA 20797634
GO:0016604 nuclear body IDA 20797634
genes like me logo Genes that share ontologies with ZBTB1: view

Pathways for ZBTB1 Gene

genes like me logo Genes that share pathways with ZBTB1: view

Interacting Proteins for ZBTB1 Gene

Gene Ontology (GO) - Biological Process for ZBTB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20797634
GO:0002711 positive regulation of T cell mediated immunity ISS --
GO:0030183 B cell differentiation IEA --
GO:0032825 positive regulation of natural killer cell differentiation ISS --
GO:0033077 T cell differentiation in thymus IEA --
genes like me logo Genes that share ontologies with ZBTB1: view

Transcripts for ZBTB1 Gene

Unigene Clusters for ZBTB1 Gene

Zinc finger and BTB domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBTB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: -
SP3:
SP4: - - - - - - -
SP5: - - -

Relevant External Links for ZBTB1 Gene

GeneLoc Exon Structure for
ZBTB1
ECgene alternative splicing isoforms for
ZBTB1

Expression for ZBTB1 Gene

mRNA expression in normal human tissues for ZBTB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZBTB1 Gene

SOURCE GeneReport for Unigene cluster for ZBTB1 Gene Hs.605143

genes like me logo Genes that share expressions with ZBTB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBTB1 Gene

Orthologs for ZBTB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBTB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBTB1 35
  • 99.86 (n)
  • 100 (a)
ZBTB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZBTB1 35
  • 94.16 (n)
  • 98.04 (a)
ZBTB1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBTB1 35
  • 94.29 (n)
  • 97.19 (a)
ZBTB1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbtb1 35
  • 89.33 (n)
  • 95.22 (a)
Zbtb1 16
Zbtb1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZBTB1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBTB1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbtb1 35
  • 85.72 (n)
  • 93.12 (a)
chicken
(Gallus gallus)
Aves ZBTB1 35
  • 80.44 (n)
  • 83.9 (a)
ZBTB1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBTB1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8507 35
tropical clawed frog
(Silurana tropicalis)
Amphibia zbtb1 35
  • 66.91 (n)
  • 62.11 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26061 35
zbtb1 35
  • 57.75 (n)
  • 53.67 (a)
zbtb1 36
  • 49 (a)
OneToOne
Species with no ortholog for ZBTB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBTB1 Gene

ENSEMBL:
Gene Tree for ZBTB1 (if available)
TreeFam:
Gene Tree for ZBTB1 (if available)

Paralogs for ZBTB1 Gene

Paralogs for ZBTB1 Gene

genes like me logo Genes that share paralogs with ZBTB1: view

Variants for ZBTB1 Gene

Sequence variations from dbSNP and Humsavar for ZBTB1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs926803 -- 64,511,021(-) ACCTA(G/T)AACTT intron-variant
rs1453007 -- 64,507,485(+) TCACC(A/G)TGTAC intron-variant
rs1453008 -- 64,512,804(+) TCAAG(A/G)AGAAA intron-variant
rs1470851 -- 64,509,402(+) CCAAA(C/G)AGAGT intron-variant
rs1966865 -- 64,509,143(+) GGCAG(A/G)CGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBTB1 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv521823 CNV Loss 19592680
nsv826966 CNV Gain 20364138

Relevant External Links for ZBTB1 Gene

HapMap Linkage Disequilibrium report
ZBTB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBTB1 Gene

Disorders for ZBTB1 Gene

(1) OMIM Diseases for ZBTB1 Gene (176797)

(1) MalaCards Diseases for ZBTB1 Gene

Search for ZBTB1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZBTB1 Gene

Relevant External Links for ZBTB1

Genetic Association Database (GAD)
ZBTB1
genes like me logo Genes that share disorders with ZBTB1: view

No data available for UniProtKB/Swiss-Prot for ZBTB1 Gene

Publications for ZBTB1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. (PMID: 20797634) Matic I. … Vertegaal A.C. (Mol. Cell 2010) 3 4
  4. Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development. (PMID: 22753936) Punwani D. … Puck J.M. (J. Immunol. 2012) 3 4
  5. Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE. (PMID: 21706167) Liu Q. … Wang J.C. (Mol. Cell. Biochem. 2011) 3 4

Products for ZBTB1 Gene

Sources for ZBTB1 Gene

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