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Aliases & Descriptions for ZBP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| C20ORF183 5 | | C20orf183 2, 3 | | DAI 2 | | DLM-1 1, 2 | | DLM1 1, 2, 3, 5 | | OTTHUMP00000031373 2 | | dJ718J7.3 1 |
| | | Descriptions |
|---|
| DNA-dependent activator of interferon regulatory factors 2 | | Tumor stroma and activated macrophage protein DLM-1 2, 3 | | Z-DNA binding protein 1 2 | | chromosome 20 open reading frame 183 1 |
|
| | Search outside databases for aliases for ZBP1 genePrevious GC identifers: GC20M055907 GC20M056817 GC20M056864 |
Summaries for ZBP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ZBP1: DLM1 encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.[supplied by OMIM] UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171Function: May play a role in host defense against tumors and pathogens. Binds Z-DNA (By similarity)Gene Wiki entry for ZBP1 |
Genomic Location for ZBP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ZBP1 gene 
Entrez Gene cytogenetic band: 20q13.31 Ensembl cytogenetic band: 20q13.31 HGNC cytogenetic band: 20q13.31ZBP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M055602:
(about GC identifiers)
Start:
|
55,612,308 bp from pter |
End:
|
55,629,038 bp from pter |
Size:
|
16,731 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011362.9
| Proteins for ZBP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171 (See
protein sequence)Recommended Name: Z-DNA-binding protein 1 Size: 429 amino acids; 46343 Da
PDB structures from and Proteopedia :3EYI (3D)
 
Secondary accessions: Q5JY39 Q9BYW4Alternative splicing: 5 isoforms: Q9H171-1 Q9H171-2 Q9H171-3 Q9H171-4 Q9H171-5 (Additional isoforms seem to exist)Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001153889.1 NP_001153890.1 NP_001153891.1 NP_110403.2
ENSEMBL proteins: ENSP00000340584 ENSP00000379167 ENSP00000350306 ENSP00000360215 ENSP00000344954
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | About this table
Antibodies for ZBP1: Assays for ZBP1: | Protein
Domains/ Families for ZBP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H171
ProtoNet protein and cluster: Q9H171 1 Blocks protein family: IPB000607 Double-stranded RNA-specific adenosine deaminase (DRADA)
UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171Similarity: Contains 2 DRADA repeats | Gene Function for ZBP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_030776
Applied Biosystems Silencer® siRNAs for ZBP1
Sigma-Aldrich siRNA for ZBP1  Sigma-Aldrich shRNA for ZBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_030776                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030776                                  untagged cDNA clones in CMV expression vector (see all 2): BC028218 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_030776
UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171Function: May play a role in host defense against tumors and pathogens. Binds Z-DNA (By similarity)Genatlas biochemistry entry for ZBP1:beta-actin mRNA zipcode binding protein,68kDa,,some homology with KOC,possibly involved in localization of beta-actin at the leading edge of fibroblasts1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Zbp1):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for ZBP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for ZBP1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for ZBP1 
5/13 Interacting proteins for ZBP1 (Q9H1712 ENSP000003405843) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for ZBP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ZBP1
|
Transcripts for ZBP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_030776
Sigma-Aldrich siRNA for ZBP1  Sigma-Aldrich shRNA for ZBP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_030776 REFSEQ mRNAs for ZBP1 gene (4 alternative transcripts): NM_001160417.1 NM_001160418.1 NM_001160419.1 NM_030776.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_030776               OriGene GFP tagged cDNA clone in CMV expression vector: NM_030776                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030776                                  untagged cDNA clones in CMV expression vector (see all 2): BC028218  Additional cDNA sequence: AJ300575.1 AK122761.1 AK128405.1 AK290918.1 AK314062.1 BC028218.1 BC131706.1 6 DOTS entries: DT.91863900 DT.75126443 DT.100738532 DT.101980400 DT.100738531 DT.120813261 21 AceView cDNA sequences:BC028218 BF507915 AX775975 AJ300575 AW085614 AK122761 AI659939 NM_030776 AX775973 AW449265 AK128405 BM681709 BI910829 BX280705 N23727 CA433778 BM727331 BF511589 AW401499 AI925506 BQ319297
highest scoring ESTs for ZBP1:AJ300575 AK122761 BM727331 AI659939 AK128405 AW085614 AW401499 BC028218 BI910829 NM_030776 Unigene Cluster for ZBP1: Z-DNA binding protein 1 Hs.302123 [show with all ESTs]Unigene Representative Sequence: AK128405
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZBP1 (see all 9
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ZBP1
5 Ensembl transcripts including schematic representations: ENST00000343535
ENST00000395822
ENST00000357677
ENST00000371173
ENST00000340462
|
Expression for ZBP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZBP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZBP1
1 / 2 / 3 5 probe-sets matching ZBP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTAGGGAGAC
SOURCE GeneReport for Unigene cluster: Hs.302123 UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171Tissue specificity: Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver |
Orthologs for ZBP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZBP1 gene from 4 species
About this table Species with no ortholog for ZBP1
ENSEMBL Gene Tree for ZBP1 | Paralogs for ZBP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for ZBP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZBP1 (up to first 250kb)
|
Disorders & Mutations for ZBP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606750
|
Medical News for ZBP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ZBP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for ZBP1 gene (see all 15
):- Complex regulation of the human gene for the Z-DNA binding protein DLM-1. (PubMed id 11842111)1, 2, 3, 4 Rothenburg S.... Haag F. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. (PubMed id 11524677)1, 3 Schwartz T....Rich A. (2001)
- The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA. (PubMed id 19095800)1, 3 Ha S.C....Kim K.K. (2008)
- Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappaB activation via the DNA-dependent activator of IFN regulatory factors. (PubMed id 18941233)3 Kaiser W.J....Mocarski E.S. (2008)
- IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). (PubMed id 18771559)3 Lippmann J....Opitz B. (2008)
- Biochemical characterization and preliminary X-ray crystallographic study of the domains of human ZBP1 bound to left-handed Z-DNA. (PubMed id 16448869)3 Ha S.C....Kim Y.G. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for ZBP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZBP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZBP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ZBP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ZBP1:

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Incremental update: 13 Oct 2009
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