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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZBP1 Gene

protein-coding   GIFtS: 61
GCID: GC20M056178

Z-DNA Binding Protein 1

(Previous name: chromosome 20 open reading frame 183)
(Previous symbol: C20orf183)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Z-DNA Binding Protein 11 2     DAI2
C20orf1831 2 3     DLM-12
DLM12 3 5     DNA-Dependent Activator Of IFN-Regulatory Factors2
DNA-Dependent Activator Of IRFs1 2     DNA-Dependent Activator Of Interferon Regulatory Factors2
Tumor Stroma And Activated Macrophage Protein DLM-12 3     Z-DNA-Binding Protein 12
Chromosome 20 Open Reading Frame 1831     C20ORF1835

External Ids:    HGNC: 161761   Entrez Gene: 810302   Ensembl: ENSG000001242567   OMIM: 6067505   UniProtKB: Q9H1713   

Export aliases for ZBP1 gene to outside databases

Previous GC identifers: GC20M055907 GC20M056817 GC20M056864 GC20M055602 GC20M052960


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZBP1 Gene:
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by
binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for ZBP1 Gene: 
ZBP1 (Z-DNA binding protein 1) is a protein-coding gene. Diseases associated with ZBP1 include constipation, and ileus, and among its related super-pathways are Cytosolic sensors of pathogen-associated DNA and ZBP1(DAI) mediated induction of type I IFNs. GO annotations related to this gene include RNA binding and left-handed Z-DNA binding.

UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171
Function: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even
host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which,
when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream
interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production.
ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and
RIPK3 (By similarity)

Gene Wiki entry for ZBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZBP1 gene promoter:
         HEN1   Elk-1   ISGF-3   Tal-1   Lmo2   E47   Ik-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31

ZBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBP1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M056178:  view genomic region     (about GC identifiers)

Start:
56,178,902 bp from pter      End:
56,195,632 bp from pter
Size:
16,731 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171 (See protein sequence)
Recommended Name: Z-DNA-binding protein 1  
Size: 429 amino acids; 46343 Da
4 PDB 3D structures from and Proteopedia for ZBP1:
2L4M (3D)        2LNB (3D)        3EYI (3D)        4KA4 (3D)    
Secondary accessions: A2A2F7 B3KVA1 F5GYT1 Q5JY39 Q9BYW4
Alternative splicing: 7 isoforms:  Q9H171-1   Q9H171-2   Q9H171-3   Q9H171-4   Q9H171-5   Q9H171-6   Q9H171-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZBP1: NX_Q9H171

Explore proteomics data for ZBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H171

  • ZBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZBP1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001153889.1  NP_001153890.1  NP_001153891.1  NP_110403.2  

    ENSEMBL proteins: 
     ENSP00000360215   ENSP00000379167   ENSP00000404620   ENSP00000440552   ENSP00000344954  
     ENSP00000340584  
    Reactome Protein details: Q9H171
    Human Recombinant Protein Products for ZBP1: 
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    Cloud-Clone Corp. Proteins for ZBP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19158679
    GO:0005737cytoplasm IDA19158679
    GO:0005829cytosol TAS--

    ZBP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR000607 dsRNA_A_deaminase
     IPR025735 RHIM_dom

    Graphical View of Domain Structure for InterPro Entry Q9H171

    ProtoNet protein and cluster: Q9H171

    1 Blocks protein domain: IPB000607 Double-stranded RNA-specific adenosine deaminase (DRADA)

    UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171
    Similarity: Contains 2 DRADA repeats


    ZBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZBP1_HUMAN, Q9H171
    Function: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even
    host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which,
    when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream
    interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production.
    ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and
    RIPK3 (By similarity)

         Genatlas biochemistry entry for ZBP1:
    beta-actin mRNA zipcode binding protein,68kDa,,some homology with KOC,possibly involved in localization of
    beta-actin at the leading edge of fibroblasts

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA17618271
    GO:0003692left-handed Z-DNA binding NAS11842111
    GO:0003723RNA binding IEA--
    GO:0003726double-stranded RNA adenosine deaminase activity IEA--
    GO:0005515protein binding IPI19590578
         
    ZBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZBP1:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zbp1):
     immune system 

    ZBP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zbp1tm1Aki for ZBP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZBP1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytosolic DNA-sensing pathway
    Cytosolic DNA-sensing pathway0.36
    Cytosolic sensors of pathogen-associated DNA 0.36
    2RIP-mediated NFkB activation via ZBP1
    RIP-mediated NFkB activation via ZBP10.85
    ZBP1(DAI) mediated induction of type I IFNs0.85
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    4IRF3-mediated induction of type I IFN
    IRF3 mediated activation of type 1 IFN0.50
    5Regulation of innate immune responses to cytosolic DNA
    Regulation of innate immune responses to cytosolic DNA

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for ZBP1 (see all 7)
        ZBP1(DAI) mediated induction of type I IFNs
    Cytosolic sensors of pathogen-associated DNA
    Regulation of innate immune responses to cytosolic DNA
    RIP-mediated NFkB activation via ZBP1
    IRF3 mediated activation of type 1 IFN


    1         Kegg Pathway  (Kegg details for ZBP1):
        Cytosolic DNA-sensing pathway


    ZBP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for ZBP1 (Q9H1712, 3 ENSP000003602154) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RIPK3Q9Y5722, 3, ENSP000002162744MINT-7255975 MINT-7256020 MINT-7256003 MINT-7255987 I2D: score=2 STRING: ENSP00000216274
    KRR1Q136012, 3, ENSP000002292144MINT-7255942 MINT-7255958 MINT-7255929 I2D: score=1 STRING: ENSP00000229214
    CTBP2P565453, ENSP000003118254I2D: score=1 STRING: ENSP00000311825
    ORC3Q9UBD53, ENSP000002577894I2D: score=1 STRING: ENSP00000257789
    PLXDC2Q6UX713, ENSP000003664604I2D: score=1 STRING: ENSP00000366460
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0032481positive regulation of type I interferon production TAS--
    GO:0045087innate immune response TAS--
    GO:0060340positive regulation of type I interferon-mediated signaling pathway IEA--

    ZBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZBP1

    Search CenterWatch for drugs/clinical trials and news about ZBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZBP1 gene (4 alternative transcripts): 
    NM_001160417.1  NM_001160418.1  NM_001160419.2  NM_030776.2  

    Unigene Cluster for ZBP1:

    Z-DNA binding protein 1
    Hs.302123  [show with all ESTs]
    Unigene Representative Sequence: NM_030776
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371173 ENST00000395822(uc002xyp.3) ENST00000461547 ENST00000453793
    ENST00000541799 ENST00000480037(uc010zzn.2) ENST00000546110 ENST00000538947
    ENST00000432548 ENST00000340462(uc002xyo.3 uc010gjm.3) ENST00000343535

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AJ300575.1 AK122761.1 AK290918.1 AK314062.1 BC131706.1 

    5 DOTS entries:

    DT.91863900  DT.100738532  DT.75126443  DT.100738531  DT.120813261 

    21 AceView cDNA sequences:

    BF507915 AW085614 BC028218 AX775973 AK122761 AX775975 AJ300575 AI659939 
    NM_030776 CA433778 N23727 AW449265 BI910829 BM681709 BM727331 AK128405 
    BX280705 BF511589 AW401499 AI925506 BQ319297 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZBP1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                -     -                 -                             -           -                                 
    SP2:                                -     -     -           -                             -           -                                 
    SP3:                                                        -                             -                                             
    SP4:                                -     -                 -                                                                           
    SP5:                                      -                 -                                                                           


    ECgene alternative splicing isoforms for ZBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZBP1 expression in normal human tissues (normalized intensities)      ZBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGGGAGAC
    ZBP1 Expression
    About this image


    ZBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             neutrophils   
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate

    See ZBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZBP1

    SOURCE GeneReport for Unigene cluster: Hs.302123

    UniProtKB/Swiss-Prot: ZBP1_HUMAN, Q9H171
    Tissue specificity: Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow
    and spleen. Expressed to a lesser extent in thymus, lung and liver

        SABiosciences Expression via Pathway-Focused PCR Array including ZBP1: 
              Antibacterial Response in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZBP1 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbp11 , 5 Z-DNA binding protein 11, 5 65.18(n)1
    51.84(a)1
      2 (95.83 cM)5
    582031  NM_021394.21  NP_067369.21 
     1732066125 


    ENSEMBL Gene Tree for ZBP1 (if available)
    TreeFam Gene Tree for ZBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/637 SNPs in ZBP1 are shown (see all 637)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848868281,2
    --56147815(+) TAAAAA/GATCCT 3 -- int10--------
    rs1492746421,2
    --56147835(+) AGGCTA/GAGGAG 3 -- int10--------
    rs1444190441,2
    --56147864(+) CGGGTG/TATAAG 3 -- int10--------
    rs1901904141,2
    --56147878(+) GTCAGA/GTGGCC 3 -- int10--------
    rs124799431,2
    C,H--56147880(+) CAGGTT/GGCCAC 3 -- int11Minor allele frequency- G:0.00NA 2
    rs1824127191,2
    --56147892(+) ATGGGC/TCTTGA 3 -- int10--------
    rs1391169991,2
    C--56147913(+) CCTCAA/GGTGAG 3 -- int10--------
    rs1438670671,2
    C--56147919(+) GTGAGA/GAGAGA 3 -- int10--------
    rs1859777391,2
    --56147927(+) AGAGTA/GGGGCA 3 -- int10--------
    rs1915684141,2
    --56147929(+) AGTGGA/GGCAGT 3 -- int10--------

    HapMap Linkage Disequilibrium report for ZBP1 (56178902 - 56195632 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912961CNV Loss21882294
    dgv1336e1CNV Complex17122850
    dgv1337e1CNV Complex17122850
    dgv1338e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606750    OMIM disorders: --

    8 diseases for ZBP1:    About MalaCards
    constipation    ileus    tonsillitis    hepatitis b
    alzheimer's disease    hepatitis    breast cancer    neuronitis


    ZBP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ZBP1
    Human Genome Epidemiology (HuGE) Navigator: ZBP1 (5 documents)

    Export disorders for ZBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZBP1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ZBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complex regulation of the human gene for the Z-DNA binding protein DLM-1. (PubMed id 11842111)1, 2, 3, 9 Rothenburg S.... Haag F. (2002)
    2. The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA. (PubMed id 19095800)1, 2, 9 Ha S.C....Kim K.K. (2008)
    3. Hippocampal atrophy as a quantitative trait in a geno me-wide association study identifying novel susceptibility genes for Alzheimer' s disease. (PubMed id 19668339)1, 4 Potkin S.G....Macciardi F. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. (PubMed id 19846511)1, 9 DeFilippis V.R....FrA1h K. (2010)
    8. Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. (PubMed id 11524677)1, 9 Schwartz T....Rich A. (2001)
    9. DNA sensing-independent inhibition of herpes simplex v irus 1 replication by DAI/ZBP1. (PubMed id 23283962)1 Pham T.H....Ahn J.H. (2013)
    10. DNA-dependent activator of interferon-regulatory facto rs (DAI) promotes lupus nephritis by activating the calcium pathway. (PubMed id 23553627)1 Zhang W....Xiong S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81030 HGNC: 16176 AceView: ZBP1 Ensembl:ENSG00000124256 euGenes: HUgn81030
    ECgene: ZBP1 Kegg: 81030 H-InvDB: ZBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZBP1 gene:
    Search GeneIP for patents involving ZBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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