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Aliases for ZBP1 Gene

Aliases for ZBP1 Gene

  • Z-DNA Binding Protein 1 2 3
  • C20ORF183 3 4 6
  • DLM1 3 4 6
  • Tumor Stroma And Activated Macrophage Protein DLM-1 3 4
  • DNA-Dependent Activator Of IRFs 2 3
  • DNA-Dependent Activator Of Interferon Regulatory Factors 3
  • DNA-Dependent Activator Of IFN-Regulatory Factors 3
  • Chromosome 20 Open Reading Frame 183 2
  • Z-DNA-Binding Protein 1 3
  • DLM-1 3
  • DAI 3

External Ids for ZBP1 Gene

Previous HGNC Symbols for ZBP1 Gene

  • C20orf183

Previous GeneCards Identifiers for ZBP1 Gene

  • GC20M055907
  • GC20M056817
  • GC20M056864
  • GC20M055602
  • GC20M056178
  • GC20M052960

Summaries for ZBP1 Gene

Entrez Gene Summary for ZBP1 Gene

  • This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ZBP1 Gene

ZBP1 (Z-DNA Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include RNA binding and left-handed Z-DNA binding.

UniProtKB/Swiss-Prot for ZBP1 Gene

  • Participates in the detection by the hosts innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).

Gene Wiki entry for ZBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBP1 Gene

Genomics for ZBP1 Gene

Regulatory Elements for ZBP1 Gene

Genomic Location for ZBP1 Gene

Start:
57,603,846 bp from pter
End:
57,620,576 bp from pter
Size:
16,731 bases
Orientation:
Minus strand

Genomic View for ZBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBP1 Gene

Proteins for ZBP1 Gene

  • Protein details for ZBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H171-ZBP1_HUMAN
    Recommended name:
    Z-DNA-binding protein 1
    Protein Accession:
    Q9H171
    Secondary Accessions:
    • A2A2F7
    • B3KVA1
    • F5GYT1
    • Q5JY39
    • Q9BYW4

    Protein attributes for ZBP1 Gene

    Size:
    429 amino acids
    Molecular mass:
    46343 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZBP1 Gene

    Alternative splice isoforms for ZBP1 Gene

neXtProt entry for ZBP1 Gene

Proteomics data for ZBP1 Gene at MOPED

Post-translational modifications for ZBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBP1 Gene

Antibody Products

  • R&D Systems Antibodies for ZBP1 (ZBP1/DLM-1/DAI)

No data available for DME Specific Peptides for ZBP1 Gene

Domains for ZBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H171

UniProtKB/Swiss-Prot:

ZBP1_HUMAN :
  • Q9H171
Similarity:
  • Contains 2 DRADA repeats.
genes like me logo Genes that share domains with ZBP1: view

No data available for Gene Families for ZBP1 Gene

Function for ZBP1 Gene

Molecular function for ZBP1 Gene

GENATLAS Biochemistry:
beta-actin mRNA zipcode binding protein,68kDa,,some homology with KOC,possibly involved in localization of beta-actin at the leading edge of fibroblasts
UniProtKB/Swiss-Prot Function:
Participates in the detection by the hosts innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).

Gene Ontology (GO) - Molecular Function for ZBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 17618271
GO:0003692 left-handed Z-DNA binding NAS 11842111
GO:0003723 RNA binding IEA --
GO:0003726 double-stranded RNA adenosine deaminase activity IEA --
GO:0005515 protein binding IPI 19590578
genes like me logo Genes that share ontologies with ZBP1: view

Phenotypes for ZBP1 Gene

genes like me logo Genes that share phenotypes with ZBP1: view

Animal Models for ZBP1 Gene

MGI Knock Outs for ZBP1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZBP1 Gene

Localization for ZBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBP1 Gene COMPARTMENTS Subcellular localization image for ZBP1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19158679
GO:0005737 cytoplasm IDA 19158679
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ZBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBP1 Gene

Pathways for ZBP1 Gene

genes like me logo Genes that share pathways with ZBP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ZBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0045087 innate immune response TAS --
GO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with ZBP1: view

Transcripts for ZBP1 Gene

Unigene Clusters for ZBP1 Gene

Z-DNA binding protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:

Relevant External Links for ZBP1 Gene

GeneLoc Exon Structure for
ZBP1
ECgene alternative splicing isoforms for
ZBP1

Expression for ZBP1 Gene

mRNA expression in normal human tissues for ZBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZBP1 Gene

This gene is overexpressed in Whole Blood (22.9) and Spleen (7.8).

Protein differential expression in normal tissues for ZBP1 Gene

This gene is overexpressed in Platelet (65.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZBP1 Gene

SOURCE GeneReport for Unigene cluster for ZBP1 Gene Hs.302123

mRNA Expression by UniProt/SwissProt for ZBP1 Gene

Q9H171-ZBP1_HUMAN
Tissue specificity: Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver
genes like me logo Genes that share expressions with ZBP1: view

Expression partners for ZBP1 Gene

In Situ Assay Products

Orthologs for ZBP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBP1 35
  • 69.85 (n)
  • 56.19 (a)
ZBP1 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbp1 35
  • 65.18 (n)
  • 51.84 (a)
Zbp1 16
Zbp1 36
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZBP1 35
  • 98.83 (n)
  • 97.9 (a)
ZBP1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbp1 35
  • 63.25 (n)
  • 50.77 (a)
dog
(Canis familiaris)
Mammalia ZBP1 36
  • 49 (a)
OneToOne
Species with no ortholog for ZBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBP1 Gene

ENSEMBL:
Gene Tree for ZBP1 (if available)
TreeFam:
Gene Tree for ZBP1 (if available)

Paralogs for ZBP1 Gene

No data available for Paralogs for ZBP1 Gene

Variants for ZBP1 Gene

Sequence variations from dbSNP and Humsavar for ZBP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs742724 -- 57,610,076(-) ATTCA(C/T)TCTCA intron-variant
rs761342 -- 57,610,823(-) TCGGG(A/G)GTGGA intron-variant
rs1411202 -- 57,618,149(+) CAGAC(A/G)CAGGT intron-variant
rs1831323 -- 57,618,202(+) TGGGC(A/G)GGGGC intron-variant
rs2073145 - 57,615,578(-) CAGCC(A/G)AGAGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZBP1 Gene

Variant ID Type Subtype PubMed ID
dgv1336e1 CNV Complex 17122850
dgv1337e1 CNV Complex 17122850
dgv1338e1 CNV Complex 17122850
nsv912961 CNV Loss 21882294

Relevant External Links for ZBP1 Gene

HapMap Linkage Disequilibrium report
ZBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBP1 Gene

Disorders for ZBP1 Gene

Relevant External Links for ZBP1

Genetic Association Database (GAD)
ZBP1
Human Genome Epidemiology (HuGE) Navigator
ZBP1

No disorders were found for ZBP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZBP1 Gene

Publications for ZBP1 Gene

  1. Complex regulation of the human gene for the Z-DNA binding protein DLM-1. (PMID: 11842111) Rothenburg S. … Haag F. (Nucleic Acids Res. 2002) 2 3 4 23
  2. The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z- DNA. (PMID: 19095800) Ha S.C. … Kim K.K. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 23
  3. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. (PMID: 19846511) DeFilippis V.R. … FrA1h K. (J. Virol. 2010) 3 23
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ZBP1 Gene

Sources for ZBP1 Gene

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