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Aliases for ZBED8 Gene

Aliases for ZBED8 Gene

  • Zinc Finger BED-Type Containing 8 2 3 5
  • Transposon-Derived Buster3 Transposase-Like Protein 3 4
  • Zinc Finger BED Domain-Containing Protein 8 3 4
  • C5orf54 3 4
  • Buster3 3 4
  • Chromosome 5 Open Reading Frame 54 2
  • Protein ZBED8 3

External Ids for ZBED8 Gene

Previous HGNC Symbols for ZBED8 Gene

  • C5orf54

Summaries for ZBED8 Gene

GeneCards Summary for ZBED8 Gene

ZBED8 (Zinc Finger BED-Type Containing 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is FAM200B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED8 Gene

Genomics for ZBED8 Gene

Regulatory Elements for ZBED8 Gene

Enhancers for ZBED8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G160008 1.1 ENCODE 62.2 +390.6 390578 2.3 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZBED8 PWWP2A LINC02202 C1QTNF2 RNF145 ENSG00000223908 TTC1 FABP6
GH05G160315 1.1 Ensembl ENCODE 30.5 +83.8 83820 1.7 ELF3 TBP FOXA2 ARID4B RARA RFX5 ZNF121 SCRT2 RCOR1 FOS ZBED8 CCNJL C1QTNF2 SNRPEP1 GC05P160291
GH05G160197 1.3 Ensembl ENCODE 10.3 +202.3 202255 1.5 PKNOX1 ATF1 ARNT E2F7 GLI4 TCF12 ELK1 GATA2 MCM3 MCM5 FABP6 ZBED8 LOC105377690
GH05G160080 1.2 Ensembl ENCODE 10.3 +319.1 319103 1.4 PKNOX1 WRNIP1 FEZF1 TCF12 TSHZ1 REST ZNF592 SMARCA4 PBX2 HMBOX1 PWWP2A FABP6 CCNJL ZBED8 GC05P160046
GH05G160398 1.1 ENCODE 11.2 +0.2 176 2.2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS DEK SP3 ZBED8 GC05M160381
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBED8 on UCSC Golden Path with GeneCards custom track

Promoters for ZBED8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189978 397 1401 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS DEK SP3

Genomic Location for ZBED8 Gene

Chromosome:
5
Start:
160,393,148 bp from pter
End:
160,400,097 bp from pter
Size:
6,950 bases
Orientation:
Minus strand

Genomic View for ZBED8 Gene

Genes around ZBED8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED8 Gene

Proteins for ZBED8 Gene

  • Protein details for ZBED8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ13-ZBED8_HUMAN
    Recommended name:
    Protein ZBED8
    Protein Accession:
    Q8IZ13
    Secondary Accessions:
    • D3DQJ9
    • Q9H5S8
    • Q9UH87

    Protein attributes for ZBED8 Gene

    Size:
    594 amino acids
    Molecular mass:
    68327 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.

neXtProt entry for ZBED8 Gene

Post-translational modifications for ZBED8 Gene

  • Ubiquitination at posLast=574574
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBED8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED8 Gene

Domains & Families for ZBED8 Gene

Protein Domains for ZBED8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBED8: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZBED8 Gene

Function for ZBED8 Gene

Gene Ontology (GO) - Molecular Function for ZBED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZBED8: view
genes like me logo Genes that share phenotypes with ZBED8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED8 Gene

Localization for ZBED8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBED8 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ZBED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZBED8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBED8 Gene

Pathways & Interactions for ZBED8 Gene

SuperPathways for ZBED8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZBED8: view

No data available for Pathways by source and SIGNOR curated interactions for ZBED8 Gene

Drugs & Compounds for ZBED8 Gene

No Compound Related Data Available

Transcripts for ZBED8 Gene

mRNA/cDNA for ZBED8 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED8 Gene

No ASD Table

Relevant External Links for ZBED8 Gene

GeneLoc Exon Structure for
ZBED8
ECgene alternative splicing isoforms for
ZBED8

Expression for ZBED8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZBED8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBED8 Gene

This gene is overexpressed in Ovary (45.0) and Heart (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZBED8 Gene



Protein tissue co-expression partners for ZBED8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBED8 Gene:

ZBED8

Evidence on tissue expression from TISSUES for ZBED8 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZBED8: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZBED8 Gene

Orthologs for ZBED8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBED8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5orf54 35
  • 100 (a)
OneToOne
C5H5orf54 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia C5orf54 35
  • 95 (a)
OneToOne
C4H5orf54 34
  • 92.93 (n)
cow
(Bos Taurus)
Mammalia ZBED8 34 35
  • 91.25 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX664605.1 35
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
ManyToMany
Species where no ortholog for ZBED8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBED8 Gene

ENSEMBL:
Gene Tree for ZBED8 (if available)
TreeFam:
Gene Tree for ZBED8 (if available)

Paralogs for ZBED8 Gene

Paralogs for ZBED8 Gene

(5) SIMAP similar genes for ZBED8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBED8: view

Variants for ZBED8 Gene

Sequence variations from dbSNP and Humsavar for ZBED8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000234097 -- 160,401,617(+) CAAAT(A/G)TTAGA downstream-variant-500B, upstream-variant-2KB
rs1000465140 -- 160,402,005(+) CACTG(A/T)TTCTA upstream-variant-2KB, utr-variant-3-prime
rs1001017048 -- 160,399,223(+) ATAAC(A/T)AAGTA intron-variant
rs1001611935 -- 160,395,341(+) TTAAA(A/G)TGGTC reference, synonymous-codon
rs1002214961 -- 160,397,165(+) ATGAA(A/T)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBED8 Gene

Variant ID Type Subtype PubMed ID
esv3607367 CNV gain 21293372
esv3607370 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv5097 CNV deletion 18451855

Variation tolerance for ZBED8 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBED8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED8 Gene

Disorders for ZBED8 Gene

Relevant External Links for ZBED8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED8

No disorders were found for ZBED8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED8 Gene

Publications for ZBED8 Gene

  1. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3 4 64
  2. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit A.F.A. (Curr. Opin. Genet. Dev. 1999) 2 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Weight loss after gastric bypass is associated with a variant at 15q26.1. (PMID: 23643386) Hatoum I.J. … Kaplan L.M. (Am. J. Hum. Genet. 2013) 3 64

Products for ZBED8 Gene

Sources for ZBED8 Gene

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