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Aliases for ZBED8 Gene

Aliases for ZBED8 Gene

  • Zinc Finger BED-Type Containing 8 2 3
  • Transposon-Derived Buster3 Transposase-Like Protein 3 4
  • Zinc Finger BED Domain-Containing Protein 8 3 4
  • Zinc Finger, BED-Type Containing 8 3 5
  • C5orf54 3 4
  • Buster3 3 4
  • Chromosome 5 Open Reading Frame 54 2

External Ids for ZBED8 Gene

Previous HGNC Symbols for ZBED8 Gene

  • C5orf54

Summaries for ZBED8 Gene

GeneCards Summary for ZBED8 Gene

ZBED8 (Zinc Finger BED-Type Containing 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED8 Gene

Genomics for ZBED8 Gene

Regulatory Elements for ZBED8 Gene

Enhancers for ZBED8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZBED8 on UCSC Golden Path with GeneCards custom track

Promoters for ZBED8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBED8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBED8 Gene

Chromosome:
5
Start:
160,393,148 bp from pter
End:
160,400,097 bp from pter
Size:
6,950 bases
Orientation:
Minus strand

Genomic View for ZBED8 Gene

Genes around ZBED8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED8 Gene

Proteins for ZBED8 Gene

  • Protein details for ZBED8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ13-ZBED8_HUMAN
    Recommended name:
    Protein ZBED8
    Protein Accession:
    Q8IZ13
    Secondary Accessions:
    • D3DQJ9
    • Q9H5S8
    • Q9UH87

    Protein attributes for ZBED8 Gene

    Size:
    594 amino acids
    Molecular mass:
    68327 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be derived from an ancient transposon that has lost its ability to translocate. Exhibits a close evolutionary relationship with ZBED5, but does not contain any zinc finger.

neXtProt entry for ZBED8 Gene

Proteomics data for ZBED8 Gene at MOPED

Post-translational modifications for ZBED8 Gene

  • Ubiquitination at Lys 574
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBED8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED8 Gene

Domains & Families for ZBED8 Gene

Protein Domains for ZBED8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZBED8: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZBED8 Gene

Function for ZBED8 Gene

Gene Ontology (GO) - Molecular Function for ZBED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IBA --
genes like me logo Genes that share ontologies with ZBED8: view

Phenotypes for ZBED8 Gene

genes like me logo Genes that share phenotypes with ZBED8: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED8 Gene

Localization for ZBED8 Gene

Gene Ontology (GO) - Cellular Components for ZBED8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZBED8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for ZBED8 Gene

Pathways & Interactions for ZBED8 Gene

SuperPathways for ZBED8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBED8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBED8 Gene

Drugs & Compounds for ZBED8 Gene

No Compound Related Data Available

Transcripts for ZBED8 Gene

mRNA/cDNA for ZBED8 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED8 Gene

No ASD Table

Relevant External Links for ZBED8 Gene

GeneLoc Exon Structure for
ZBED8
ECgene alternative splicing isoforms for
ZBED8

Expression for ZBED8 Gene

mRNA expression in normal human tissues for ZBED8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBED8 Gene

This gene is overexpressed in Ovary (45.0) and Heart (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBED8 Gene



genes like me logo Genes that share expression patterns with ZBED8: view

Protein tissue co-expression partners for ZBED8 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBED8 Gene

Orthologs for ZBED8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBED8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBED8 35
  • 91.25 (n)
  • 92.93 (a)
ZBED8 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H5orf54 35
  • 92.93 (n)
  • 94.78 (a)
C5orf54 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf54 35
  • 99.38 (n)
  • 99.66 (a)
C5orf54 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii BX664605.1 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
Species with no ortholog for ZBED8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBED8 Gene

ENSEMBL:
Gene Tree for ZBED8 (if available)
TreeFam:
Gene Tree for ZBED8 (if available)

Paralogs for ZBED8 Gene

(5) SIMAP similar genes for ZBED8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZBED8: view

Variants for ZBED8 Gene

Sequence variations from dbSNP and Humsavar for ZBED8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10515808 - 160,393,924(+) AAATG(A/C)TGTGA reference, missense
rs2910177 -- 160,396,092(+) TCCGT(C/T)ACCCA intron-variant
rs2910178 -- 160,396,698(+) ctgtg(A/G)aaaaa intron-variant
rs1075059 -- 160,398,791(+) TGCGC(G/T)TTTGT intron-variant
rs1075060 -- 160,399,072(+) GGGTA(C/T)ACATC intron-variant

Variation tolerance for ZBED8 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ZBED8 Gene

Disorders for ZBED8 Gene

Relevant External Links for ZBED8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED8

No disorders were found for ZBED8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED8 Gene

Publications for ZBED8 Gene

  1. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3 4 67
  2. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit A.F.A. (Curr. Opin. Genet. Dev. 1999) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Weight loss after gastric bypass is associated with a variant at 15q26.1. (PMID: 23643386) Hatoum I.J. … Kaplan L.M. (Am. J. Hum. Genet. 2013) 3

Products for ZBED8 Gene

Sources for ZBED8 Gene

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