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Aliases for ZBED6 Gene

Aliases for ZBED6 Gene

  • Zinc Finger BED-Type Containing 6 2 3 5
  • Zinc Finger BED Domain-Containing Protein 6 3
  • MGR 3

External Ids for ZBED6 Gene

Previous GeneCards Identifiers for ZBED6 Gene

  • GC01U902782
  • GC01P203766

Summaries for ZBED6 Gene

Entrez Gene Summary for ZBED6 Gene

  • The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is located within the first intron of the ZC3H11A gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZBED6 Gene

ZBED6 (Zinc Finger BED-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protein dimerization activity. An important paralog of this gene is ZBED4.

UniProtKB/Swiss-Prot for ZBED6 Gene

  • Transcriptional repressor which binds to the consensus sequence 5-GCTCGC-3 and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED6 Gene

Genomics for ZBED6 Gene

Regulatory Elements for ZBED6 Gene

Enhancers for ZBED6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZBED6 on UCSC Golden Path with GeneCards custom track

Promoters for ZBED6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBED6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBED6 Gene

Chromosome:
1
Start:
203,796,309 bp from pter
End:
203,800,558 bp from pter
Size:
4,250 bases
Orientation:
Plus strand

Genomic View for ZBED6 Gene

Genes around ZBED6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED6 Gene

Proteins for ZBED6 Gene

  • Protein details for ZBED6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86452-ZBED6_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 6
    Protein Accession:
    P86452

    Protein attributes for ZBED6 Gene

    Size:
    979 amino acids
    Molecular mass:
    109973 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene.

neXtProt entry for ZBED6 Gene

Post-translational modifications for ZBED6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED6 Gene

Domains & Families for ZBED6 Gene

Gene Families for ZBED6 Gene

Protein Domains for ZBED6 Gene

Suggested Antigen Peptide Sequences for ZBED6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P86452

UniProtKB/Swiss-Prot:

ZBED6_HUMAN :
  • Contains 2 BED-type zinc fingers.
Similarity:
  • Contains 2 BED-type zinc fingers.
genes like me logo Genes that share domains with ZBED6: view

Function for ZBED6 Gene

Molecular function for ZBED6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which binds to the consensus sequence 5-GCTCGC-3 and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).

Gene Ontology (GO) - Molecular Function for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ZBED6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBED6 Gene

Localization for ZBED6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBED6 Gene

Nucleus. Nucleus, nucleolus. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus. {ECO:0000250 UniProtKB:D2EAC2}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBED6 Gene COMPARTMENTS Subcellular localization image for ZBED6 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with ZBED6: view

Pathways & Interactions for ZBED6 Gene

SuperPathways for ZBED6 Gene

No Data Available

Interacting Proteins for ZBED6 Gene

Selected Interacting proteins: P86452-ZBED6_HUMAN for ZBED6 Gene via IID

Symbol External ID(s) Details
SMC6

Gene Ontology (GO) - Biological Process for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZBED6: view

No data available for Pathways by source and SIGNOR curated interactions for ZBED6 Gene

Drugs & Compounds for ZBED6 Gene

No Compound Related Data Available

Transcripts for ZBED6 Gene

mRNA/cDNA for ZBED6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBED6 Gene

Zinc finger, BED-type containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED6 Gene

No ASD Table

Relevant External Links for ZBED6 Gene

GeneLoc Exon Structure for
ZBED6
ECgene alternative splicing isoforms for
ZBED6

Expression for ZBED6 Gene

mRNA expression in normal human tissues for ZBED6 Gene

mRNA expression in normal human tissues for ZBED6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBED6 Gene

This gene is overexpressed in Islet of Langerhans (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBED6 Gene



Protein tissue co-expression partners for ZBED6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBED6 Gene:

ZBED6

SOURCE GeneReport for Unigene cluster for ZBED6 Gene:

Hs.716666
genes like me logo Genes that share expression patterns with ZBED6: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBED6 Gene

Orthologs for ZBED6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBED6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBED6 34
  • 91.1 (n)
  • 90.28 (a)
ZBED6 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBED6 34
  • 91.73 (n)
  • 93.14 (a)
ZBED6 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbed6 34
  • 89.49 (n)
  • 89.56 (a)
Zbed6 16
Zbed6 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBED6 35
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730718 34
  • 48.93 (n)
  • 38.05 (a)
zebrafish
(Danio rerio)
Actinopterygii BX530070.1 35
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13775 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C10A4.1 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for ZBED6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBED6 Gene

ENSEMBL:
Gene Tree for ZBED6 (if available)
TreeFam:
Gene Tree for ZBED6 (if available)

Paralogs for ZBED6 Gene

Paralogs for ZBED6 Gene

Pseudogenes.org Pseudogenes for ZBED6 Gene

genes like me logo Genes that share paralogs with ZBED6: view

Variants for ZBED6 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBED6 Gene

Variant ID Type Subtype PubMed ID
nsv520482 CNV loss 19592680

Variation tolerance for ZBED6 Gene

Gene Damage Index Score: 11.79; 93.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBED6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ZBED6 Gene

Disorders for ZBED6 Gene

Relevant External Links for ZBED6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED6

No disorders were found for ZBED6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED6 Gene

Publications for ZBED6 Gene

  1. ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. (PMID: 20016685) Markljung E. … Andersson L. (PLoS Biol. 2009) 2 3 4 65
  2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3 65
  3. Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin. (PMID: 20375320) Andersson L. (Cold Spring Harb. Symp. Quant. Biol. 2009) 2 3 65
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  5. Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells. (PMID: 26056301) Akhtar Ali M. … SjAPblom T. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 65

Products for ZBED6 Gene

Sources for ZBED6 Gene

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