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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZBED6 Gene

protein-coding GIFtS: 34
GCID: GC01P203766

zinc finger, BED-type containing 6

Search for ZBED6
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger, BED-Type Containing 6¹ ²
MGR²
Zinc Finger BED Domain-Containing Protein 6²

External Ids:	HGNC: 33273¹	Entrez Gene: 100381270²	Ensembl: ENSG00000257315⁷	OMIM: 613512⁵	UniProtKB: P86452³

Export aliases for ZBED6 gene to outside databases

Previous GC identifer: GC01U902782

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBED6_HUMAN, P86452

Function: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of

IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ZBED6
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBED6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

ZBED6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBED6 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P203766: view genomic region (about GC identifiers)

Start:	203,765,437 bp from pter	End:	203,769,686 bp from pter
Size:	4,250 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZBED6_HUMAN, P86452 (See protein sequence)

Recommended Name: Zinc finger BED domain-containing protein 6

Size: 979 amino acids; 109973 Da

Subcellular location: Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Located predominantly in the

nucleolus but is also dispersed throughout the nucleus (By similarity)

Miscellaneous: Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene

Explore the universe of human proteins at neXtProt for ZBED6: NX_P86452

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P86452

ZBED6 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001167579.1

ENSEMBL proteins:

ENSP00000447879

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005730	nucleolus	ISS	--

ZBED6 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZBED6 for domains About GeneDecksing

3 InterPro domains/families:

IPR008906 HATC

IPR012337 RNaseH-like_dom

IPR003656 Znf_BED_prd

Graphical View of Domain Structure for InterPro Entry P86452

ProtoNet protein and cluster: P86452

UniProtKB/Swiss-Prot: ZBED6_HUMAN, P86452

Similarity: Contains 2 BED-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZBED6_HUMAN, P86452

Function: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of

IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity)

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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

ZBED6 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZBED6

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	ISS	--

ZBED6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZBED6
Search CenterWatch for drugs/clinical trials and news about ZBED6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZBED6 gene:

NM_001174108.1

Unigene Cluster for ZBED6:

Zinc finger, BED-type containing 6

Hs.716666 [show with all ESTs]

Unigene Representative Sequence: NM_001174108

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000550078(uc021phs.1)

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Additional cDNA sequence: AF086224.1

4 DOTS entries:

DT.100802807 DT.121452763 DT.208858 DT.95368226

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZBED6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTGTTTTG

About this image

ZBED6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for ZBED6

SOURCE GeneReport for Unigene cluster: Hs.716666

SABiosciences Custom PCR Arrays for ZBED6

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ZBED6 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 10)	--	29(a) 29(a) (see all 10)	possible ortholog possible ortholog (see all 10)	LGf(449914-450844) 1(18093100-18094015)
zebrafish (Danio rerio)	Actinopterygii	CR293521.1⁶	--	16(a)	possible ortholog	12(38939186-38942627)
fruit fly (Drosophila melanogaster)	Insecta	CG13775⁶	--	15(a)	possible ortholog	2L(6954585-6956872)
worm (Caenorhabditis elegans)	Secernentea	B0545.4⁶ K09A11.1⁶ (see all 4)	Protein K09A11.1 (see all 4)	18(a) 18(a) (see all 4)	possible ortholog possible ortholog (see all 4)	IV(109054-109943) X(13262431-13264518)

ENSEMBL Gene Tree for ZBED6 (if available)
TreeFam Gene Tree for ZBED6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZBED6 gene

ZBED4² ZBED1²

ZBED6 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for ZBED6
PGOHUM00000261308 PGOHUM00000261507

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149167258^1,2		--	203766662(+)	`GTATGC/TACTCT`	2	C	syn¹		0	--	--	--	--
rs183154956^1,2		--	203766848(+)	`AAGAAA/GGGTTT`	2	K	syn¹		0	--	--	--	--
rs187086393^1,2		--	203766877(+)	`GCGTCA/GAAAAA`	2	Q R	mis¹		0	--	--	--	--
rs191911955^1,2		--	203766893(+)	`ATTCTC/TGCCAA`	2	L	syn¹		0	--	--	--	--
rs142248061^1,2	C,	--	203766895(+)	`TCTTGC/TCAAAA`	2	A V	mis¹		0	--	--	--	--
rs151253583^1,2		--	203766953(+)	`GCTTTA/GTTAGC`	2	L	syn¹		0	--	--	--	--
rs3737972^1,2	C,F,A,H,	--	203766964(+)	`TTCCAA/GTGACC`	2	N S	mis¹		25		EA NA NS CSA WA	2644
rs182386491^1,2		--	203767210(+)	`CAGGGC/TCAACA`	2	A V	mis¹		0	--	--	--	--
rs187873517^1,2		--	203767315(+)	`TGATCC/GATTAG`	2	P R	mis¹		0	--	--	--	--
rs6697388^1,2	C,F,A,H,	--	203767822(+)	`CACTCT/GGATGC`	2	/R /L	mis¹		26		NA NS EA WA	2788

HapMap Linkage Disequilibrium report for ZBED6 (203765437 - 203769686 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBED6: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZBED6 for disorders About MalaCards

ZBED6 for disorders About GeneDecksing

OMIM gene information: 613512 OMIM disorders: --

Export disorders for ZBED6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZBED6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBED6)

Utopia: connect your pdf to the dynamic
world of online information

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. (PubMed id 20016685)^{1, 2, 3} Markljung E.... Andersson L. (2009)
Studying phenotypic evolution in domestic animals: a walk in the footsteps of charles darwin. (PubMed id 20375320)^{1, 3} Andersson L. (2009)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
A domesticated transposon mediates the effects of a s ingle-nucleotide polymorphism responsible for enhanced muscle growth. (PubMed id 20134481)¹ Butter F....Mann M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 100381270	HGNC: 33273	Ensembl:ENSG00000257315	euGenes: HUgn100381270	ECgene: ZBED6
H-InvDB: ZBED6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZBED6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZBED6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZBED6 gene:
Search GeneIP for patents involving ZBED6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBED6

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ZBED6
	Browse SwitchGear Promoter luciferase reporter plasmids for ZBED6

Search ThermoFisher Antibodies for ZBED6

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZBED6

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZBED6 gene at Home site.

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ZBED6 Gene

zinc finger, BED-type containing 6

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ZBED6 Gene

zinc finger, BED-type containing 6

Aliasesfor ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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for ZBED6 gene

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