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Aliases for ZBED6 Gene

Aliases for ZBED6 Gene

  • Zinc Finger, BED-Type Containing 6 2 3
  • Zinc Finger BED Domain-Containing Protein 6 3
  • MGR 3

External Ids for ZBED6 Gene

Summaries for ZBED6 Gene

GeneCards Summary for ZBED6 Gene

ZBED6 (Zinc Finger, BED-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is ZBED1.

UniProtKB/Swiss-Prot for ZBED6 Gene

  • Transcriptional repressor which binds to the consensus sequence 5-GCTCGC-3 and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED6 Gene

Genomics for ZBED6 Gene

Genomic Location for ZBED6 Gene

Start:
203,796,309 bp from pter
End:
203,800,558 bp from pter
Size:
4,250 bases
Orientation:
Plus strand

Genomic View for ZBED6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBED6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED6 Gene

No data available for Regulatory Elements for ZBED6 Gene

Proteins for ZBED6 Gene

  • Protein details for ZBED6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86452-ZBED6_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 6
    Protein Accession:
    P86452
    Secondary Accessions:

    Protein attributes for ZBED6 Gene

    Size:
    979 amino acids
    Molecular mass:
    109973 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene

neXtProt entry for ZBED6 Gene

Proteomics data for ZBED6 Gene at MOPED

Post-translational modifications for ZBED6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED6 Gene

Domains for ZBED6 Gene

Gene Families for ZBED6 Gene

HGNC:
  • ZBED :Zinc fingers, BED-type

Protein Domains for ZBED6 Gene

UniProtKB/Swiss-Prot:

ZBED6_HUMAN
Similarity:
  • Contains 2 BED-type zinc fingers.:
    • P86452
genes like me logo Genes that share domains with ZBED6: view

Function for ZBED6 Gene

Molecular function for ZBED6 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor which binds to the consensus sequence 5-GCTCGC-3 and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).

Gene Ontology (GO) - Molecular Function for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ZBED6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZBED6 Gene

Localization for ZBED6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBED6 Gene

Nucleus. Nucleus, nucleolus. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus. {ECO:0000250 UniProtKB:D2EAC2}.

Gene Ontology (GO) - Cellular Components for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with ZBED6: view

Pathways for ZBED6 Gene

SuperPathways for ZBED6 Gene

No Data Available

Interacting Proteins for ZBED6 Gene

Gene Ontology (GO) - Biological Process for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZBED6: view

No data available for Pathways by source for ZBED6 Gene

Transcripts for ZBED6 Gene

mRNA/cDNA for ZBED6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBED6 Gene

Zinc finger, BED-type containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED6 Gene

No ASD Table

Relevant External Links for ZBED6 Gene

GeneLoc Exon Structure for
ZBED6
ECgene alternative splicing isoforms for
ZBED6

Expression for ZBED6 Gene

mRNA expression in normal human tissues for ZBED6 Gene

mRNA expression in normal human tissues for ZBED6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZBED6 Gene

SOURCE GeneReport for Unigene cluster for ZBED6 Gene Hs.716666

genes like me logo Genes that share expressions with ZBED6: view

Orthologs for ZBED6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBED6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBED6 36
  • 91.1 (n)
  • 90.28 (a)
ZBED6 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBED6 36
  • 91.73 (n)
  • 93.14 (a)
ZBED6 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zbed6 36
  • 89.49 (n)
  • 89.56 (a)
Zbed6 16
Zbed6 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBED6 37
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730718 36
  • 48.93 (n)
  • 38.05 (a)
zebrafish
(Danio rerio)
Actinopterygii BX530070.1 37
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13775 37
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C10A4.1 37
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
Species with no ortholog for ZBED6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBED6 Gene

ENSEMBL:
Gene Tree for ZBED6 (if available)
TreeFam:
Gene Tree for ZBED6 (if available)

Paralogs for ZBED6 Gene

Paralogs for ZBED6 Gene

Pseudogenes.org Pseudogenes for ZBED6 Gene

genes like me logo Genes that share paralogs with ZBED6: view

Variants for ZBED6 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBED6 Gene

Variant ID Type Subtype PubMed ID
nsv873111 CNV Gain 21882294
nsv520482 CNV Loss 19592680

Relevant External Links for ZBED6 Gene

HapMap Linkage Disequilibrium report
ZBED6

No data available for Sequence variations from dbSNP and Humsavar for ZBED6 Gene

Disorders for ZBED6 Gene

No disorders were found for ZBED6 Gene.

No data available for UniProtKB/Swiss-Prot for ZBED6 Gene

Publications for ZBED6 Gene

  1. ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. (PMID: 20016685) Markljung E. … Andersson L. (PLoS Biol. 2009) 2 3 4
  2. Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin. (PMID: 20375320) Andersson L. (Cold Spring Harb. Symp. Quant. Biol. 2009) 2 3
  3. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth. (PMID: 20134481) Butter F. … Mann M. (EMBO Rep. 2010) 3

Products for ZBED6 Gene

Sources for ZBED6 Gene

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