Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZBED6 Gene

Aliases for ZBED6 Gene

  • Zinc Finger BED-Type Containing 6 2 3 5
  • Zinc Finger BED Domain-Containing Protein 6 3
  • MGR 3

External Ids for ZBED6 Gene

Previous GeneCards Identifiers for ZBED6 Gene

  • GC01U902782
  • GC01P203766

Summaries for ZBED6 Gene

Entrez Gene Summary for ZBED6 Gene

  • The protein encoded by this transposon-derived intronless gene is a transcriptional repressor that binds to the consensus sequence 5'-GCTCGC-3'. The encoded protein has been shown to repress IGF2 transcription. This gene is located within the first intron of the ZC3H11A gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZBED6 Gene

ZBED6 (Zinc Finger BED-Type Containing 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protein dimerization activity. An important paralog of this gene is ZBED4.

UniProtKB/Swiss-Prot for ZBED6 Gene

  • Transcriptional repressor which binds to the consensus sequence 5-GCTCGC-3 and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED6 Gene

Genomics for ZBED6 Gene

Regulatory Elements for ZBED6 Gene

Enhancers for ZBED6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F204511 0.6 FANTOM5 ENCODE 58.2 +720.8 720772 11.9 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 MDM4 ZBED6 GYG2P2 SNRPE PPP1R15B PIK3C2B LOC101929459 ENSG00000236108 LOC105371691 RBBP5
GH01F203860 0.5 ENCODE 56.7 +65.2 65247 2.9 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC SNRPE ZBED6 MDM4 PPP1R15B HNRNPA1P59 LOC100506747 PRELP LOC105371691 CYB5R1 LAX1
GH01F202926 1.1 ENCODE 42.2 -869.2 -869245 1.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZBED6 RNPEP SNRPE ENSG00000273478 PRELP HNRNPA1P59 RPS27P8 LOC100506672 LOC102723465 KLHL12
GH01F204505 0.5 Ensembl ENCODE 39.3 +711.1 711092 4.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBED6 SNRPE MDM4 GYG2P2 PPP1R15B RBBP5 LRRN2 PIK3C2B TRK-TTT3-2
GH01F204415 1.6 FANTOM5 Ensembl ENCODE 32.7 +622.2 622211 5.7 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 ZNF548 FOS PPP1R15B MDM4 GYG2P2 ZBED6 SNRPE PIK3C2B RBBP5 PRELP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZBED6 on UCSC Golden Path with GeneCards custom track

Promoters for ZBED6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082233 -209 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for ZBED6 Gene

Chromosome:
1
Start:
203,796,309 bp from pter
End:
203,800,558 bp from pter
Size:
4,250 bases
Orientation:
Plus strand

Genomic View for ZBED6 Gene

Genes around ZBED6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED6 Gene

Proteins for ZBED6 Gene

  • Protein details for ZBED6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P86452-ZBED6_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 6
    Protein Accession:
    P86452

    Protein attributes for ZBED6 Gene

    Size:
    979 amino acids
    Molecular mass:
    109973 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene.

neXtProt entry for ZBED6 Gene

Post-translational modifications for ZBED6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED6 Gene

Domains & Families for ZBED6 Gene

Gene Families for ZBED6 Gene

Protein Domains for ZBED6 Gene

Suggested Antigen Peptide Sequences for ZBED6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P86452

UniProtKB/Swiss-Prot:

ZBED6_HUMAN :
  • Contains 2 BED-type zinc fingers.
Similarity:
  • Contains 2 BED-type zinc fingers.
genes like me logo Genes that share domains with ZBED6: view

Function for ZBED6 Gene

Molecular function for ZBED6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which binds to the consensus sequence 5-GCTCGC-3 and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).

Gene Ontology (GO) - Molecular Function for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBED6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBED6 Gene

Localization for ZBED6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBED6 Gene

Nucleus. Nucleus, nucleolus. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus. {ECO:0000250 UniProtKB:D2EAC2}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBED6 Gene COMPARTMENTS Subcellular localization image for ZBED6 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with ZBED6: view

Pathways & Interactions for ZBED6 Gene

SuperPathways for ZBED6 Gene

No Data Available

Interacting Proteins for ZBED6 Gene

Selected Interacting proteins: P86452-ZBED6_HUMAN for ZBED6 Gene via IID

Symbol External ID(s) Details
SMC6

Gene Ontology (GO) - Biological Process for ZBED6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZBED6: view

No data available for Pathways by source and SIGNOR curated interactions for ZBED6 Gene

Transcripts for ZBED6 Gene

mRNA/cDNA for ZBED6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZBED6 Gene

Zinc finger, BED-type containing 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED6 Gene

No ASD Table

Relevant External Links for ZBED6 Gene

GeneLoc Exon Structure for
ZBED6
ECgene alternative splicing isoforms for
ZBED6

Expression for ZBED6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBED6 Gene

mRNA expression in normal human tissues for ZBED6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBED6 Gene

This gene is overexpressed in Islet of Langerhans (64.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBED6 Gene



Protein tissue co-expression partners for ZBED6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBED6 Gene:

ZBED6

SOURCE GeneReport for Unigene cluster for ZBED6 Gene:

Hs.716666
genes like me logo Genes that share expression patterns with ZBED6: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBED6 Gene

Orthologs for ZBED6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBED6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ZBED6 34 35
  • 91.73 (n)
cow
(Bos Taurus)
Mammalia ZBED6 34 35
  • 91.1 (n)
mouse
(Mus musculus)
Mammalia Zbed6 34 16 35
  • 89.49 (n)
lizard
(Anolis carolinensis)
Reptilia ZBED6 35
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730718 34
  • 48.93 (n)
zebrafish
(Danio rerio)
Actinopterygii BX530070.1 35
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13775 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C10A4.1 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for ZBED6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBED6 Gene

ENSEMBL:
Gene Tree for ZBED6 (if available)
TreeFam:
Gene Tree for ZBED6 (if available)

Paralogs for ZBED6 Gene

Paralogs for ZBED6 Gene

genes like me logo Genes that share paralogs with ZBED6: view

Variants for ZBED6 Gene

Sequence variations from dbSNP and Humsavar for ZBED6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10494843 -- 203,799,243(+) AATCA(A/G)AGATG intron-variant, reference, missense
rs10494844 -- 203,800,763(+) TAGAT(G/T)GAACT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111458126 -- 203,795,613(+) TACCG(C/G)CCGGG upstream-variant-2KB, utr-variant-5-prime
rs112583525 -- 203,795,962(+) CCTCC(A/C)GGTCG intron-variant, upstream-variant-2KB
rs113708222 -- 203,795,675(+) GTTTT(C/T)TGCTA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZBED6 Gene

Variant ID Type Subtype PubMed ID
nsv520482 CNV loss 19592680

Variation tolerance for ZBED6 Gene

Gene Damage Index Score: 11.79; 93.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBED6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED6 Gene

Disorders for ZBED6 Gene

Relevant External Links for ZBED6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED6

No disorders were found for ZBED6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED6 Gene

Publications for ZBED6 Gene

  1. ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. (PMID: 20016685) Markljung E. … Andersson L. (PLoS Biol. 2009) 2 3 4 64
  2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3 64
  3. Studying phenotypic evolution in domestic animals: a walk in the footsteps of Charles Darwin. (PMID: 20375320) Andersson L. (Cold Spring Harb. Symp. Quant. Biol. 2009) 2 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ZBED6 Gene

Sources for ZBED6 Gene

Content
Loading form....