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Aliases for ZBED5 Gene

Aliases for ZBED5 Gene

  • Zinc Finger, BED-Type Containing 5 2 3
  • Transposon-Derived Buster1 Transposase-Like Protein 3 4
  • Buster1 3 4

External Ids for ZBED5 Gene

Previous GeneCards Identifiers for ZBED5 Gene

  • GC11M010831
  • GC11M010547
  • GC11M010835
  • GC11M010840
  • GC11M010843

Summaries for ZBED5 Gene

Entrez Gene Summary for ZBED5 Gene

  • This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

GeneCards Summary for ZBED5 Gene

ZBED5 (Zinc Finger, BED-Type Containing 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is FAM200B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED5 Gene

Genomics for ZBED5 Gene

Regulatory Elements for ZBED5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBED5 Gene

Chromosome:
11
Start:
10,812,074 bp from pter
End:
10,858,796 bp from pter
Size:
46,723 bases
Orientation:
Minus strand

Genomic View for ZBED5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBED5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED5 Gene

Proteins for ZBED5 Gene

  • Protein details for ZBED5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AG3-ZBED5_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 5
    Protein Accession:
    Q49AG3
    Secondary Accessions:
    • B2RCC1
    • Q05D82
    • Q86WW3
    • Q9NT24
    • Q9UBJ4

    Protein attributes for ZBED5 Gene

    Size:
    693 amino acids
    Molecular mass:
    78911 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be derived from an ancient transposon that has lost its ability to translocate
    SequenceCaution:
    • Sequence=AAH17803.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47754.1; Type=Frameshift; Positions=495; Evidence={ECO:0000305};

neXtProt entry for ZBED5 Gene

Proteomics data for ZBED5 Gene at MOPED

Post-translational modifications for ZBED5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED5 Gene

No data available for DME Specific Peptides for ZBED5 Gene

Domains & Families for ZBED5 Gene

Gene Families for ZBED5 Gene

Protein Domains for ZBED5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49AG3

UniProtKB/Swiss-Prot:

ZBED5_HUMAN :
  • Contains 1 BED-type zinc finger.
Similarity:
  • Contains 1 BED-type zinc finger.
genes like me logo Genes that share domains with ZBED5: view

Function for ZBED5 Gene

Gene Ontology (GO) - Molecular Function for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBED5: view
genes like me logo Genes that share phenotypes with ZBED5: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBED5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED5 Gene

Localization for ZBED5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBED5 Gene COMPARTMENTS Subcellular localization image for ZBED5 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZBED5 Gene

Pathways & Interactions for ZBED5 Gene

SuperPathways for ZBED5 Gene

No Data Available

Interacting Proteins for ZBED5 Gene

Selected Interacting proteins: Q49AG3-ZBED5_HUMAN for ZBED5 Gene via MINT I2D

Symbol External ID(s) Details
SMAD4

Gene Ontology (GO) - Biological Process for ZBED5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBED5 Gene

Drugs & Compounds for ZBED5 Gene

No Compound Related Data Available

Transcripts for ZBED5 Gene

Unigene Clusters for ZBED5 Gene

Zinc finger, BED-type containing 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBED5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED5 Gene

No ASD Table

Relevant External Links for ZBED5 Gene

GeneLoc Exon Structure for
ZBED5
ECgene alternative splicing isoforms for
ZBED5

Expression for ZBED5 Gene

mRNA expression in normal human tissues for ZBED5 Gene

Protein differential expression in normal tissues from HIPED for ZBED5 Gene

This gene is overexpressed in Lung (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZBED5 Gene



SOURCE GeneReport for Unigene cluster for ZBED5 Gene Hs.655066

genes like me logo Genes that share expression patterns with ZBED5: view

Protein tissue co-expression partners for ZBED5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBED5 Gene

Orthologs for ZBED5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBED5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBED5 35
  • 95 (n)
  • 97.55 (a)
ZBED5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBED5 35
  • 94.37 (n)
  • 98.41 (a)
ZBED5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2410018M08Rik 35
  • 47.54 (n)
  • 39.18 (a)
2410018M08Rik 16
2410018M08Rik 36
  • 30 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ZBED5 35
  • 99.66 (n)
  • 99.57 (a)
ZBED5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbed5 35
  • 47.62 (n)
  • 39.12 (a)
lizard
(Anolis carolinensis)
Reptilia ZBED5 36
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX664605.1 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
Species with no ortholog for ZBED5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBED5 Gene

ENSEMBL:
Gene Tree for ZBED5 (if available)
TreeFam:
Gene Tree for ZBED5 (if available)

Paralogs for ZBED5 Gene

Paralogs for ZBED5 Gene

(5) SIMAP similar genes for ZBED5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZBED5: view

Variants for ZBED5 Gene

Sequence variations from dbSNP and Humsavar for ZBED5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14229 -- 10,855,574(+) TACTG(C/T)CATTA intron-variant
rs15752 -- 10,855,785(+) ATAAA(C/T)GTTTA intron-variant
rs15891 -- 10,855,318(+) AAGAA(A/G)GGGAC intron-variant
rs812211 -- 10,855,639(+) CAATT(C/T)TGAAG intron-variant
rs976999 -- 10,855,481(+) CTTTA(C/T)GTACA intron-variant

Variation tolerance for ZBED5 Gene

Gene Damage Index Score: 4.60; 65.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBED5 Gene

HapMap Linkage Disequilibrium report
ZBED5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBED5 Gene

Disorders for ZBED5 Gene

Relevant External Links for ZBED5

Genetic Association Database (GAD)
ZBED5
Human Genome Epidemiology (HuGE) Navigator
ZBED5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED5
genes like me logo Genes that share disorders with ZBED5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED5 Gene

Publications for ZBED5 Gene

  1. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 67
  2. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit A.F.A. (Curr. Opin. Genet. Dev. 1999) 2 67
  3. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer N.D. … Sladek R. (PLoS ONE 2012) 67
  4. Comparative analysis of the recently discovered hAT transposon TcBuster in human cells. (PMID: 23166581) Woodard L.E. … Wilson M.H. (PLoS ONE 2012) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for ZBED5 Gene

Sources for ZBED5 Gene

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