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Aliases for ZBED5 Gene

Aliases for ZBED5 Gene

  • Zinc Finger BED-Type Containing 5 2 3 5
  • Transposon-Derived Buster1 Transposase-Like Protein 3 4
  • Buster1 3 4
  • Zinc Finger BED Domain-Containing Protein 5 3

External Ids for ZBED5 Gene

Previous GeneCards Identifiers for ZBED5 Gene

  • GC11M010831
  • GC11M010547
  • GC11M010835
  • GC11M010840
  • GC11M010843
  • GC11M010813

Summaries for ZBED5 Gene

Entrez Gene Summary for ZBED5 Gene

  • This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

GeneCards Summary for ZBED5 Gene

ZBED5 (Zinc Finger BED-Type Containing 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is FAM200B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED5 Gene

Genomics for ZBED5 Gene

Regulatory Elements for ZBED5 Gene

Enhancers for ZBED5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F010929 0.6 Ensembl ENCODE 47.5 -74.9 -74858 7.3 ZFP64 SIN3A FEZF1 ZNF2 ZNF143 ZNF548 DEK ZNF263 SP3 REST ZBED5 ZBED5-AS1 CTR9 ENSG00000255125 ENSG00000254865 ENSG00000250041 LOC105376550
GH11F011840 0.7 FANTOM5 ENCODE 35.8 -984.7 -984659 5.3 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DEK ZBED5 USP47 PARVA ENSG00000255492
GH11F010897 1.2 FANTOM5 ENCODE 25.8 -41.4 -41436 4.6 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 FOS JUNB REST SMARCB1 ZBED5 ZBED5-AS1 CTR9 EIF4G2 ENSG00000255125 AMPD3 SNORD97 ENSG00000250041 LOC105376550
GH11F010920 0.8 Ensembl ENCODE 24.6 -61.7 -61677 0.7 HDAC1 PKNOX1 CBX3 ATF1 ARNT TBL1XR1 NFRKB CHAMP1 GATA2 BCLAF1 ZBED5 ZBED5-AS1 ENSG00000250041 LOC105376550
GH11F010316 0.8 Ensembl ENCODE 19 +540.7 540732 2.3 PKNOX1 ASH2L ZFHX2 POLR2A SCRT2 EED ZNF548 CREM EGR2 SRF ZBED5 ENSG00000254397 RPL21P97 SBF2 ENSG00000250041 AMPD3 CAND1.11 PIR60970
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZBED5 on UCSC Golden Path with GeneCards custom track

Promoters for ZBED5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000558413 795 4000 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ZBED5 Gene

Chromosome:
11
Start:
10,812,074 bp from pter
End:
10,858,796 bp from pter
Size:
46,723 bases
Orientation:
Minus strand

Genomic View for ZBED5 Gene

Genes around ZBED5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED5 Gene

Proteins for ZBED5 Gene

  • Protein details for ZBED5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49AG3-ZBED5_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 5
    Protein Accession:
    Q49AG3
    Secondary Accessions:
    • B2RCC1
    • Q05D82
    • Q86WW3
    • Q9NT24
    • Q9UBJ4

    Protein attributes for ZBED5 Gene

    Size:
    693 amino acids
    Molecular mass:
    78911 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be derived from an ancient transposon that has lost its ability to translocate.
    SequenceCaution:
    • Sequence=AAH17803.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47754.1; Type=Frameshift; Positions=495; Evidence={ECO:0000305};

neXtProt entry for ZBED5 Gene

Post-translational modifications for ZBED5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED5 Gene

No data available for DME Specific Peptides for ZBED5 Gene

Domains & Families for ZBED5 Gene

Gene Families for ZBED5 Gene

Protein Domains for ZBED5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49AG3

UniProtKB/Swiss-Prot:

ZBED5_HUMAN :
  • Contains 1 BED-type zinc finger.
Similarity:
  • Contains 1 BED-type zinc finger.
genes like me logo Genes that share domains with ZBED5: view

Function for ZBED5 Gene

Gene Ontology (GO) - Molecular Function for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBED5: view
genes like me logo Genes that share phenotypes with ZBED5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBED5 Gene

Localization for ZBED5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBED5 Gene COMPARTMENTS Subcellular localization image for ZBED5 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ZBED5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZBED5 Gene

Pathways & Interactions for ZBED5 Gene

SuperPathways for ZBED5 Gene

No Data Available

Interacting Proteins for ZBED5 Gene

Gene Ontology (GO) - Biological Process for ZBED5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZBED5: view

No data available for Pathways by source and SIGNOR curated interactions for ZBED5 Gene

Transcripts for ZBED5 Gene

Unigene Clusters for ZBED5 Gene

Zinc finger, BED-type containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED5 Gene

No ASD Table

Relevant External Links for ZBED5 Gene

GeneLoc Exon Structure for
ZBED5
ECgene alternative splicing isoforms for
ZBED5

Expression for ZBED5 Gene

mRNA expression in normal human tissues for ZBED5 Gene

Protein differential expression in normal tissues from HIPED for ZBED5 Gene

This gene is overexpressed in Lung (68.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZBED5 Gene



Protein tissue co-expression partners for ZBED5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZBED5 Gene:

ZBED5

SOURCE GeneReport for Unigene cluster for ZBED5 Gene:

Hs.655066
genes like me logo Genes that share expression patterns with ZBED5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBED5 Gene

Orthologs for ZBED5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBED5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBED5 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia ZBED5 34 35
  • 95 (n)
dog
(Canis familiaris)
Mammalia ZBED5 34 35
  • 94.37 (n)
rat
(Rattus norvegicus)
Mammalia Zbed5 34
  • 47.62 (n)
mouse
(Mus musculus)
Mammalia 2410018M08Rik 34 35
  • 47.54 (n)
Zbed5 16
lizard
(Anolis carolinensis)
Reptilia ZBED5 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX664605.1 35
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
ManyToMany
Species where no ortholog for ZBED5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBED5 Gene

ENSEMBL:
Gene Tree for ZBED5 (if available)
TreeFam:
Gene Tree for ZBED5 (if available)

Paralogs for ZBED5 Gene

Paralogs for ZBED5 Gene

(5) SIMAP similar genes for ZBED5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZBED5: view

Variants for ZBED5 Gene

Sequence variations from dbSNP and Humsavar for ZBED5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1046297 -- 10,853,508(-) CAGAT(A/G)TTTTT reference, missense
rs10840501 -- 10,852,388(+) CATCA(A/G)AATAG downstream-variant-500B
rs11042983 -- 10,856,137(+) AGGAT(A/G)AGATA intron-variant
rs111269849 -- 10,853,142(+) TTGAG(A/G)ATCAG reference, missense
rs111495524 -- 10,856,930(+) TTAAT(G/T)CCCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBED5 Gene

Variant ID Type Subtype PubMed ID
nsv483000 CNV loss 15286789

Variation tolerance for ZBED5 Gene

Gene Damage Index Score: 4.60; 65.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBED5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED5 Gene

Disorders for ZBED5 Gene

Relevant External Links for ZBED5

Genetic Association Database (GAD)
ZBED5
Human Genome Epidemiology (HuGE) Navigator
ZBED5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED5

No disorders were found for ZBED5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED5 Gene

Publications for ZBED5 Gene

  1. Interspersed repeats and other mementos of transposable elements in mammalian genomes. (PMID: 10607616) Smit A.F.A. (Curr. Opin. Genet. Dev. 1999) 2 3 4 64
  2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ZBED5 Gene

Sources for ZBED5 Gene

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