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Aliases for ZBED4 Gene

Aliases for ZBED4 Gene

  • Zinc Finger, BED-Type Containing 4 2 3
  • KIAA0637 4 6

External Ids for ZBED4 Gene

Previous GeneCards Identifiers for ZBED4 Gene

  • GC22P046837
  • GC22P048466
  • GC22P048568
  • GC22P048635
  • GC22P050247
  • GC22P033189

Summaries for ZBED4 Gene

GeneCards Summary for ZBED4 Gene

ZBED4 (Zinc Finger, BED-Type Containing 4) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is ZBED1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED4 Gene

Genomics for ZBED4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZBED4 Gene

49,853,842 bp from pter
49,890,078 bp from pter
36,237 bases
Plus strand

Genomic View for ZBED4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED4 Gene

Proteins for ZBED4 Gene

  • Protein details for ZBED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger BED domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RZH1
    • Q1ECU0
    • Q9UGG8

    Protein attributes for ZBED4 Gene

    1171 amino acids
    Molecular mass:
    130322 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=BAA31612.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZBED4 Gene

Proteomics data for ZBED4 Gene at MOPED

Post-translational modifications for ZBED4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED4 Gene

Domains for ZBED4 Gene

Gene Families for ZBED4 Gene

Protein Domains for ZBED4 Gene

Suggested Antigen Peptide Sequences for ZBED4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 BED-type zinc fingers.
  • Contains 4 BED-type zinc fingers.
genes like me logo Genes that share domains with ZBED4: view

Function for ZBED4 Gene

Gene Ontology (GO) - Molecular Function for ZBED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ZBED4: view

Phenotypes for ZBED4 Gene

GenomeRNAi human phenotypes for ZBED4:
genes like me logo Genes that share phenotypes with ZBED4: view

Animal Model Products

miRNA for ZBED4 Gene

miRTarBase miRNAs that target ZBED4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBED4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBED4 Gene

Localization for ZBED4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBED4 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for ZBED4 Gene COMPARTMENTS Subcellular localization image for ZBED4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZBED4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19369242
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 19369242
genes like me logo Genes that share ontologies with ZBED4: view

Pathways for ZBED4 Gene

SuperPathways for ZBED4 Gene

No Data Available

Interacting Proteins for ZBED4 Gene

Gene Ontology (GO) - Biological Process for ZBED4 Gene


No data available for Pathways by source for ZBED4 Gene

Transcripts for ZBED4 Gene

mRNA/cDNA for ZBED4 Gene

Unigene Clusters for ZBED4 Gene

Zinc finger, BED-type containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZBED4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED4 Gene

No ASD Table

Relevant External Links for ZBED4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZBED4 Gene

mRNA expression in normal human tissues for ZBED4 Gene

Protein differential expression in normal tissues for ZBED4 Gene

This gene is overexpressed in Heart (67.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBED4 Gene

SOURCE GeneReport for Unigene cluster for ZBED4 Gene Hs.475208

mRNA Expression by UniProt/SwissProt for ZBED4 Gene

Tissue specificity: Widely expressed with highest levels in testis, kidney and spinal cord and brain corpus callosum. Expressed in the retina, found in the cone photoreceptors, Mueller cells, cone pedicles and in the innermost retinal layer.
genes like me logo Genes that share expressions with ZBED4: view

Expression partners for ZBED4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZBED4 Gene

Orthologs for ZBED4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBED4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZBED4 35
  • 81.64 (n)
  • 82.36 (a)
ZBED4 36
  • 82 (a)
(Pan troglodytes)
Mammalia ZBED4 35
  • 98.95 (n)
  • 98.72 (a)
ZBED4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zbed4 35
  • 80.86 (n)
  • 82.95 (a)
(Mus musculus)
Mammalia Zbed4 16
Zbed4 36
  • 83 (a)
(Monodelphis domestica)
Mammalia ZBED4 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ZBED4 36
  • 76 (a)
(Gallus gallus)
Aves ZBED4 35
  • 72.96 (n)
  • 79.16 (a)
ZBED4 36
  • 79 (a)
(Anolis carolinensis)
Reptilia ZBED4 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6285 35
zbed4 35
  • 65.72 (n)
  • 70.67 (a)
(Danio rerio)
Actinopterygii Dr.17906 35
zbed4 35
  • 60.61 (n)
  • 60.21 (a)
zbed4 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13775 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea C53D6.6 36
  • 17 (a)
K09A11.1 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for ZBED4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBED4 Gene

Gene Tree for ZBED4 (if available)
Gene Tree for ZBED4 (if available)

Paralogs for ZBED4 Gene

Paralogs for ZBED4 Gene

genes like me logo Genes that share paralogs with ZBED4: view

Variants for ZBED4 Gene

Sequence variations from dbSNP and Humsavar for ZBED4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4624 -- 49,888,269(+) TTTAA(A/G)CCAAT utr-variant-3-prime
rs14913 -- 49,888,186(+) CCCAA(A/G)GACAT utr-variant-3-prime
rs733382 -- 49,859,206(+) GTTAC(C/G)TCTTA intron-variant
rs738707 -- 49,857,179(+) CATGT(A/G)CATTT intron-variant
rs738708 -- 49,857,701(+) ATTCT(C/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZBED4 Gene

Variant ID Type Subtype PubMed ID
dgv5046n71 CNV Loss 21882294
nsv915495 CNV Loss 21882294
dgv5049n71 CNV Loss 21882294
nsv829328 CNV Gain 20364138
nsv915505 CNV Loss 21882294
esv2724709 CNV Deletion 23290073
esv2724710 CNV Deletion 23290073
nsv191151 CNV Loss 16902084
esv997091 CNV Deletion 20482838
esv2724711 CNV Deletion 23290073
esv1290042 CNV Deletion 17803354
nsv191243 CNV Loss 16902084
esv2724712 CNV Deletion 23290073
nsv471221 CNV Loss 18288195
nsv915506 CNV Loss 21882294
dgv5050n71 CNV Loss 21882294
nsv915508 CNV Loss 21882294

Relevant External Links for ZBED4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED4 Gene

Disorders for ZBED4 Gene

Relevant External Links for ZBED4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ZBED4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZBED4 Gene

Publications for ZBED4 Gene

  1. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. (PMID: 19369242) Saghizadeh M. … Farber D.B. (Invest. Ophthalmol. Vis. Sci. 2009) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. (PMID: 19693800) Nyegaard M. … rglum A.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 48
  5. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3

Products for ZBED4 Gene

Sources for ZBED4 Gene

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