ZBED4 Gene
protein-coding GIFtS: 48
GCID: GC22P050247
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zinc finger, BED-type containing 4
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Aliases
for ZBED4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, BED-Type Containing 41 2 | | KIAA06371 3 5 | | Zinc Finger BED Domain-Containing Protein 42 | | Zinc Finger, BED Domain Containing 42 |
Export aliases for ZBED4 gene to outside databasesPrevious GC identifers: GC22P046837 GC22P048466 GC22P048568 GC22P048635 GC22P033189 |
Summaries
for ZBED4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZBED4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBED4 gene promoter:
LHX3b/Lhx3b MyoD HNF-4alpha2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Evi-1 HNF-4alpha1 RORalpha1 LHX3a/Lhx3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBED4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBED4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33ZBED4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P050247: view genomic region
(about GC identifiers)
Start:
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50,247,490 bp from pter |
End:
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50,283,726 bp from pter |
Size:
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36,237 bases |
Orientation:
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plus strand |
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Proteins
for ZBED4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132 (See
protein sequence)Recommended Name: Zinc finger BED domain-containing protein 4 Size: 1171 amino acids; 130322 Da
Subunit: Homodimer
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=BAA31612.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RZH1 Q1ECU0 Q9UGG8Explore the universe of human proteins at neXtProt for ZBED4: NX_O75132
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75132
ZBED4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055653.2
ENSEMBL proteins: ENSP00000216268
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZBED4 for ontologies About GeneDecksing
ZBED4 Antibody Products:
Assay Products for ZBED4: |
Protein
Domains /
Families
for ZBED4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBED4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75132ProtoNet protein and cluster: O75132 2 Blocks protein families: IPB003656 BED finger IPB008906 HAT dimerisation
UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132Similarity: Contains 4 BED-type zinc fingers |
Function
for ZBED4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZBED4 (NM_014838) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBED4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBED4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBED4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZBED4 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ZBED4:
|
Pathways & Interactions
for ZBED4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBED4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZBED4 (ENSP000002162684) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for ZBED4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBED4
Search CenterWatch for drugs/clinical trials and news about ZBED4
|
Transcripts
for ZBED4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBED4 gene: NM_014838.2 Unigene Cluster for ZBED4: Zinc finger, BED-type containing 4 Hs.475208 [show with all ESTs]Unigene Representative Sequence: NM_0148381 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000216268(uc003bix.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBED4 (NM_014838) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBED4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBED4 |
Additional cDNA sequence: AB014537.1 AK022892.1 BC117670.1 BC117671.1 BC167155.1 CR456387.1 5 DOTS entries: DT.213986 DT.40197500 DT.100777658 DT.91859531 DT.99967582 24/128 AceView cDNA sequences (see all 128): CR592522 N90088 BE250745 BM728558 BQ931361 AA564836 Z45767 BX281816 H97246 AA748853 BG390738 BM994399 BF061592 CD367744 AI276496 BP349203 AA311178 CD559167 Z41166 BU742849 AA521298 BM765792 BE887610 BM822595
GeneLoc Exon Structure
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Expression
for ZBED4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBED4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCAGTTAAC
About this image
See ZBED4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBED4
SOURCE GeneReport for Unigene cluster: Hs.475208
UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132Tissue specificity: Widely expressed with highest levels in testis, kidney and spinal cord and brain corpus callosum.Expressed in the retina, found in the cone photoreceptors, Mueller cells, cone pedicles and in the innermost retinallayer
SABiosciences Custom PCR Arrays for ZBED4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBED4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBED4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBED4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBED4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBED4 |
Orthologs
for ZBED4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZBED4 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for ZBED4 (if available)
TreeFam Gene Tree for ZBED4 (if available) |
Paralogs
for ZBED4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBED4 gene
- ZBED12 ZBED62
ZBED4 for paralogs About GeneDecksing
|
Genomic Variants
for ZBED4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for ZBED4 (50247490 - 50283726 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZBED4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBED4 |
|
Disorders
/ Diseases
for ZBED4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZBED4 for disorders About GeneDecksing
OMIM gene information: 612552
OMIM disorders: --
3  diseases for ZBED4: About MalaCardsbipolar affective disorder corpus callosum retinitis
Human Genome Epidemiology (HuGE) Navigator: ZBED4 (1 document)
Export disorders for ZBED4 gene to outside databases
|
Publications
for ZBED4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBED4 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZBED4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ZBED4, a BED-type zinc-finger protein in the cones of the human retina. (PubMed id 19369242)1, 2, 9 Saghizadeh M.... Farber D.B. (2009)
- Human DNA replication-related element binding factor (hDREF) self- association via hATC domain is necessary for its nuclear accumulation and DNA binding. (PubMed id 17209048)1, 2 Yamashita D....Hirose F. (2007)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
- Support of association between BRD1 and both schizoph renia and bipolar affective disorder. (PubMed id 19693800)1 Nyegaard M....rglum A.D. (2010)
- ZBED4, a novel retinal protein expressed in cones and MA1ller cells. (PubMed id 20238005)1 Farber D.B....Saghizadeh M. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for ZBED4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ZBED4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBED4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZBED4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBED4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZBED4 gene:
Search GeneIP for patents involving ZBED4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBED4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZBED4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBED4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBED4 | | | OriGene Protein Over-expression Lysate for ZBED4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZBED4 | | OriGene 3'-UTR Clone for ZBED4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZBED4 | | OriGene Custom Protein Services for ZBED4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBED4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBED4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBED4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBED4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBED4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBED4 |
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| | | | Search Tocris compounds for ZBED4 |
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 | | | ZBED4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBED4 |
|  |  |  | | | | ThermoFisher Antibodies for ZBED4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBED4 |
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