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ZBED4 Gene

protein-coding GIFtS: 49

GC22P048635

zinc finger, BED-type containing 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA0637 ^¹, ³, ⁵

Descriptions
zinc finger, BED domain containing 4 ^²
zinc finger, BED-type containing 4 ^²

External Ids
HGNC: 20721¹
Entrez Gene: 9889²
UniProtKB: O75132³
Ensembl: ENSG00000100426⁷

Search outside databases for aliases for ZBED4 gene

Previous GC identifers: GC22P046837 GC22P048466 GC22P048568

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZBED4 gene

Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33

ZBED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P048635: (about GC identifiers)

Start:	48,633,494 bp from pter
End:	48,669,730 bp from pter
Size:	36,237 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011525.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132 (See protein sequence)

Recommended Name: Zinc finger BED domain-containing protein 4

Size: 1171 amino acids; 130308 Da

Secondary accessions: B2RZH1 Q9UGG8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055653.2

ENSEMBL proteins:

ENSP00000216268 ENSP00000379240

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ZBED4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZBED4

Assays for ZBED4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O75132

ProtoNet protein and cluster: O75132

2 Blocks protein families:

IPB003656 BED finger

IPB008906 HAT dimerisation

UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132

Similarity: Contains 4 BED-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBED4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBED4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014838

Applied Biosystems Silencer® siRNAs for ZBED4

Sigma-Aldrich siRNA for ZBED4

Sigma-Aldrich shRNA for ZBED4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014838
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014838
untagged cDNA clones in CMV expression vector (see all 2): NM_014838

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014838

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBED4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBED4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBED4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014838

Sigma-Aldrich siRNA for ZBED4

Sigma-Aldrich shRNA for ZBED4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014838

REFSEQ mRNAs for ZBED4 gene:

NM_014838.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014838

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014838
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014838
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_014838

Additional cDNA sequence:

AB014537.1 AK022892.1 BC117670.1 BC117671.1 BC167155.1 CR456387.1 CR592522.1

5 DOTS entries:

DT.213986 DT.40197500 DT.100777658 DT.91859531 DT.99967582

24/128 AceView cDNA sequences (see all 128 ):

CR592522 BE250745 AA564836 BQ931361 BM728558 H97246 Z45767 N90088

AA748853 BX281816 AI815680 AA214563 AA521298 BX440427 BU742248 BM823412

BG120247 AA731792 BM172429 F04639 BX453055 Z45467 BM728311 CD559167

highest scoring ESTs for ZBED4:

AB014537 AA149790 AA213423 AA494305 AI815680 AI910709 AJ707794 AL041194 AL120059 AU135638

Unigene Cluster for ZBED4:

Zinc finger, BED-type containing 4

Hs.475208 [show with all ESTs]

Unigene Representative Sequence: NM_014838

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000216268 ENST00000395903

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBED4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBED4

¹ / ² / ³

4 probe-sets matching ZBED4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
81714_at²^{, 3}	U95-E	1	1.00	1.00	0.91	1.09	AI809329	0.40	1.00	0.76	1
31788_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.91	AB014537	1.00	1.00	1.00	1
204799_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014838	0.60	1.00	0.82	1
204799_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZBED4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCAGTTAAC

SOURCE GeneReport for Unigene cluster: Hs.475208
Expression variation in blood from EXPOLDB for ZBED4
UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132
Tissue specificity: Widely expressed with highest levels in testis, kidney and spinal cord and
brain corpus callosum

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBED4 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBED4¹	--	zinc finger, BED-type containing 4	82.01(n) 82.53(a)	481197 XM_538318.2 XP_538318.2
rat (Rattus norvegicus)	Zbed4¹	--	zinc finger, BED-type containing 4	80.86(n) 82.95(a)	315211 XM_235553.4 XP_235553.3
mouse (Mus musculus)	Zbed4⁵ 100043240¹	15⁵	zinc finger, BED domain containing 4⁵ predicted gene, 100043240¹	80.63(n)¹ 83.12(a)¹	100043240¹ XM_001480180.1¹ XP_001480230.1¹ AI851385⁵ AK005794⁵ (see all 12)
chicken (Gallus gallus)	ZBED4¹	--	zinc finger, BED-type containing 4	72.96(n) 79.16(a)	417734 XM_415979.2 XP_415979.2
zebrafish (Danio rerio)	Dr.17906²	--	Transcribed sequence with weak similarity to protein more	72.67(n)	CA471192.1

About this table Species with no ortholog for ZBED4

ENSEMBL Gene Tree for ZBED4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBED4 gene

ZBED1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/292 NCBI SNPs in ZBED4 are shown (see all 292 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 112)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs738711^1,2	A,C,F,H,O	48668607(+)	`CGACCG/AGCTTG`	1	--	ut3¹		8	MN EU EA WA NA	651
	rs910799^1,2	A,C,F,H,O	48664572(+)	`ATGACG/ATAGGG`	1	V/I	mis¹ ese³		11	MN EU EA WA	1198
	rs2092982^1,2	A,C,F,H,O	48668208(+)	`TAACCA/CCAGAC`	1	--	ut3¹		8	EA EU WA NA	2030
	rs2092984^1,2	A,C,F,H	48670082(+)	`attgcG/Aggctc`	1	--	ng3¹		4	EU EA WA	376
	rs738712^1,2	A,C,F,H	48668990(+)	`GAGAAT/CTGAAT`	1	--	ut3¹		13	NS MN EU EA WA NA	832
	rs4624^1,2	A,C,F,H	48667921(+)	`TTTAAG/ACCAAT`	1	--	ut3¹ ese³		16	MN NA NS EU EA WA	1058
	rs1569958^1,2	A,C,F,H	48631587(+)	`CAGTGC/TGAAGA`	1	--	ng5¹		9	MN EU EA WA	1018
	rs8139718^1,2	A,F,H	48632699(+)	`CGCGGG/ACTCCT`	1	--	ng5¹ tfbs³		4	EU EA WA	414
	rs6009917^1,2	C,F,H	48667348(+)	`GTCCCG/ACGGAG`	1	--	ut3¹ ese³		7	EU EA WA NA	556
	rs17001403^1,2	F,H	48667191(+)	`CAATTA/GTGTAC`	1	--	ut3¹ ese³		7	NA EU EA WA	556

About this table

HapMap Linkage Disequilibrium images for ZBED4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612552

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for ZBED4 gene:

A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{3, 4} Dunham I....O'Brien K.P. (1999)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{3, 4} Ishikawa K....Ohara O. (1998)
Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding. (PubMed id 17209048)³ Yamashita D....Hirose F. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9889	HGNC: 20721	AceView: ZBED4	Ensembl:ENSG00000100426	euGenes: HUgn9889
ECgene: ZBED4	H-InvDB: ZBED4

(According to HUGE)
About This Section

HUGE: KIAA0637

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBED4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBED4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBED4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBED4		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBED4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for ZBED4

Search Tocris compounds for ZBED4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ZBED4

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ZBED4 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for ZBED4

Summaries
for ZBED4

Genomic Location
for ZBED4

Proteins
for ZBED4

Protein Domains/
Families
for ZBED4

Gene Function
for ZBED4

Pathways & Interactions
for ZBED4

Drugs & Compounds
for ZBED4

Transcripts
for ZBED4

Expression
for ZBED4

Orthologs
for ZBED4

Paralogs
for ZBED4

SNPs/Variants
for ZBED4

Disorders & Mutations
for ZBED4

Medical News
for ZBED4

Publications
for ZBED4

Search for ZBED4

Genome Databases showing ZBED4

Other Databases showing ZBED4

Specialized Databases showing ZBED4

Licensable Technologies
for ZBED4

Services
for ZBED4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBED4 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor ZBED4

Summariesfor ZBED4

Genomic Locationfor ZBED4

Proteinsfor ZBED4

Protein Domains/Familiesfor ZBED4

Gene Functionfor ZBED4

Pathways & Interactionsfor ZBED4

Drugs & Compoundsfor ZBED4

Transcriptsfor ZBED4

Expression for ZBED4

Orthologsfor ZBED4

Paralogsfor ZBED4

SNPs/Variantsfor ZBED4

Disorders & Mutationsfor ZBED4

Medical Newsfor ZBED4

Publicationsfor ZBED4

Search for ZBED4

Genome Databases showing ZBED4

Other Databases showing ZBED4

Specialized Databases showing ZBED4

Licensable Technologiesfor ZBED4

Servicesfor ZBED4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBED4

Summaries
for ZBED4

Genomic Location
for ZBED4

Proteins
for ZBED4

Protein Domains/
Families
for ZBED4

Gene Function
for ZBED4

Pathways & Interactions
for ZBED4

Drugs & Compounds
for ZBED4

Transcripts
for ZBED4

Expression
for ZBED4

Orthologs
for ZBED4

Paralogs
for ZBED4

SNPs/Variants
for ZBED4

Disorders & Mutations
for ZBED4

Medical News
for ZBED4

Publications
for ZBED4

Licensable Technologies
for ZBED4

Services
for ZBED4