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ZBED4 Gene

protein-coding   GIFtS: 51
GCID: GC22P050247

Zinc Finger, BED-Type Containing 4

  Search for ZBED4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, BED-Type Containing 41 2
KIAA06373 5
Zinc Finger BED Domain-Containing Protein 42
Zinc Finger, BED Domain Containing 42

External Ids:    HGNC: 207211   Entrez Gene: 98892   Ensembl: ENSG000001004267   OMIM: 6125525   UniProtKB: O751323   

Export aliases for ZBED4 gene to outside databases

Previous GC identifers: GC22P046837 GC22P048466 GC22P048568 GC22P048635 GC22P033189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZBED4 Gene:
ZBED4 (zinc finger, BED-type containing 4) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is ZBED1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZBED4 gene promoter:
         LHX3b/Lhx3b   MyoD   HNF-4alpha2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Evi-1   HNF-4alpha1   RORalpha1   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ZBED4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZBED4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

ZBED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZBED4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050247:  view genomic region     (about GC identifiers)

Start:
50,247,490 bp from pter      End:
50,283,726 bp from pter
Size:
36,237 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132 (See protein sequence)
Recommended Name: Zinc finger BED domain-containing protein 4  
Size: 1171 amino acids; 130322 Da
Subunit: Homodimer
Sequence caution: Sequence=BAA31612.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RZH1 Q1ECU0 Q9UGG8

Explore the universe of human proteins at neXtProt for ZBED4: NX_O75132

Explore proteomics data for ZBED4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZBED4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055653.2  
    ENSEMBL proteins: 
     ENSP00000216268  

    ZBED4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZBED4

     
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    Cloud-Clone Corp. ELISAs for ZBED4
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    Search eBioscience for ELISAs for ZBED4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZBED: Zinc fingers, BED-type

    3 InterPro protein domains:
     IPR008906 HATC_dom_C
     IPR012337 RNaseH-like_dom
     IPR003656 Znf_BED_prd

    Graphical View of Domain Structure for InterPro Entry O75132

    ProtoNet protein and cluster: O75132

    2 Blocks protein domains:
    IPB003656 BED finger
    IPB008906 HAT dimerisation


    UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132
    Similarity: Contains 4 BED-type zinc fingers


    Find genes that share domains with ZBED4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with ZBED4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ZBED4:
     Cell division defect  Increased S DNA content  Increased cell size 

         1 MGI phenotypic allele for Zbed4 (no phenotypes)

    Find genes that share phenotypes with ZBED4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZBED4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZBED4
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    miRNA
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    miRTarBase miRNAs that target ZBED4:
    hsa-mir-484 (MIRT016619), hsa-mir-98-5p (MIRT027812)

    Block miRNA regulation of human, mouse, rat ZBED4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBED4 (see all 60):
    hsa-miR-549 hsa-miR-579 hsa-miR-26a-2* hsa-miR-16-1* hsa-miR-30d hsa-miR-628-3p hsa-miR-3921 hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidZBED4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBED4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZBED4_HUMAN, O75132: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA19369242

    Find genes that share ontologies with ZBED4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZBED4
    Interactions:

        Search GeneGlobe Interaction Network for ZBED4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZBED4 (ENSP000002162684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBX1ENSP000002256034STRING: ENSP00000225603
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZBED4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZBED4 gene: 
    NM_014838.2  

    Unigene Cluster for ZBED4:

    Zinc finger, BED-type containing 4
    Hs.475208  [show with all ESTs]
    Unigene Representative Sequence: NM_014838
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000216268(uc003bix.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat ZBED4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZBED4 (see all 60):
    hsa-miR-549 hsa-miR-579 hsa-miR-26a-2* hsa-miR-16-1* hsa-miR-30d hsa-miR-628-3p hsa-miR-3921 hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidZBED4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZBED4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBED4
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      QuantiTect SYBR Green Assays in human, mouse, rat ZBED4
      QuantiFast Probe-based Assays in human, mouse, rat ZBED4

    Additional mRNA sequence: 

    AB014537.1 AK022892.1 BC117670.1 BC117671.1 BC167155.1 CR456387.1 

    5 DOTS entries:

    DT.213986  DT.40197500  DT.100777658  DT.91859531  DT.99967582 

    Selected AceView cDNA sequences (see all 128):

    N90088 Z45767 BQ931361 AA748853 BE250745 BX281816 BM728558 CR592522 
    H97246 AA564836 BM824776 BI261241 AA857619 BP349203 AA731792 BE294454 
    BQ898525 BG390738 BE887610 BF028908 AA521298 AW293495 AL041194 BG765608 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZBED4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCAGTTAAC
    ZBED4 Expression
    About this image

    ZBED4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZBED4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475208

    UniProtKB/Swiss-Prot: ZBED4_HUMAN, O75132
    Tissue specificity: Widely expressed with highest levels in testis, kidney and spinal cord and brain corpus
    callosum. Expressed in the retina, found in the cone photoreceptors, Mueller cells, cone pedicles and in the
    innermost retinal layer

        Custom PCR Arrays for ZBED4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBED4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZBED4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zbed45 zinc finger, BED domain containing 4   --   15 (44.24 cM) 88751660 
    chicken
    (Gallus gallus)
    Aves ZBED41 zinc finger, BED-type containing 4 72.96(n)
    79.16(a)
      417734  NM_001199541.1  NP_001186470.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZBED46
    zinc finger, BED-type containing 4
    75(a)
    1 ↔ 1
    GL343277.1(200738-204250)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.62852 Transcribed sequence with moderate similarity to protein more 75.16(n)    BX725103.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179062 Transcribed sequence with weak similarity to protein more 72.67(n)    CA471192.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG137756
    --
    21(a)
    1 → many
    2L(6954585-6956872)
    worm
    (Caenorhabditis elegans)
    Secernentea K09A11.16
    C53D6.66
    Protein C53D6.6 (C53D6.6) mRNA, complete cds
    22(a)
    17(a)
    many ↔ many
    many ↔ many
    X(13262500-13264587) WBGene00010704
    IV(9027680-9032651) WBGene00008283


    ENSEMBL Gene Tree for ZBED4 (if available)
    TreeFam Gene Tree for ZBED4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZBED4 gene
    ZBED12  ZBED62  

    Find genes that share paralogs with ZBED4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZBED4 (see all 1139)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468450991,2
    Cuntested150280487(+) TCTGCC/TGCAGA 2 A syn11Minor allele frequency- T:0.00NA 4552
    rs771280351,2
    C--33187356(+) ACCACC/TGCATT 1 -- int13Minor allele frequency- T:0.12WA NA 240
    rs7618791,2
    C,F,A,H--33187542(+) TGCCTA/GTTATG 1 -- int122Minor allele frequency- G:0.39NS EA NA WA CSA 2348
    rs1492082401,2
    --33187583(+) CAGTTA/TCATTT 1 -- int10--------
    rs81402811,2
    C--33187598(+) tccagA/Gtaata 1 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs1871954401,2
    --33187635(+) CACTTG/TTTTTT 1 -- int10--------
    rs1129416171,2
    C,F--33187749(+) TCCCTA/GGTAGC 1 -- int13Minor allele frequency- G:0.40WA CSA 5
    rs1378698811,2
    C--33187803(+) TTTTCG/TTAGAG 1 -- int10--------
    rs1919456701,2
    --33188067(+) TCCCAC/GCGCGT 1 -- int10--------
    rs1449016741,2
    C--33188191(+) CCCTT-/CCCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZBED4 (50247490 - 50283726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZBED4 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724709CNV Deletion23290073
    esv2724712CNV Deletion23290073
    esv1290042CNV Deletion17803354
    esv997091CNV Deletion20482838
    esv2724710CNV Deletion23290073
    esv2724711CNV Deletion23290073
    nsv191243CNV Loss16902084
    nsv915495CNV Loss21882294
    nsv471221CNV Loss18288195
    dgv5049n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZBED4
    DNA2.0 Custom Variant and Variant Library Synthesis for ZBED4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612552    OMIM disorders: --


    Find genes that share disorders with ZBED4           About GenesLikeMe

    Genetic Association Database (GAD): ZBED4
    Human Genome Epidemiology (HuGE) Navigator: ZBED4 (1 document)

    Export disorders for ZBED4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZBED4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZBED4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. (PubMed id 19369242)1, 2, 9 Saghizadeh M.... Farber D.B. (Invest. Ophthalmol. Vis. Sci. 2009)
    2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PubMed id 23533661)1, 3 Hayward A.... Jern P. (PLoS ONE 2013)
    3. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. (PubMed id 19693800)1, 4 Nyegaard M....rglum A.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Human DNA replication-related element binding factor (hDREF) self- association via hATC domain is necessary for its nuclear accumulation and DNA binding. (PubMed id 17209048)1, 2 Yamashita D....Hirose F. (J. Biol. Chem. 2007)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    7. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9889 HGNC: 20721 AceView: ZBED4 Ensembl:ENSG00000100426 euGenes: HUgn9889
    ECgene: ZBED4 H-InvDB: ZBED4

    (According to HUGE)
    About This Section

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    HUGE: KIAA0637

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZBED4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZBED4 gene:
    Search GeneIP for patents involving ZBED4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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