ZBED3 Gene
protein-coding GIFtS: 44
GCID: GC05M076367
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zinc finger, BED-type containing 3
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Aliases
for ZBED3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger, BED-Type Containing 31 2 | | MGC154351 | | 2610005H11Rik2 | | Zinc Finger BED Domain-Containing Protein 32 | | Zinc Finger, BED Domain Containing 32 | | Axin-Interacting Protein3 |
Export aliases for ZBED3 gene to outside databasesPrevious GC identifers: GC05M076606 GC05M076411 GC05M076456 GC05M076408 GC05M071579 |
Summaries
for ZBED3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZBED3_HUMAN, Q96IU2Function: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway bystabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (Bysimilarity)
|
Genomic Views
for ZBED3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZBED3 gene promoter:
NF-1 NF-1/L Pax-6 Pax-2a Tal-1beta GATA-1 E47 Max S8 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZBED3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBED3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q13.3 Ensembl cytogenetic band: 5q13.3 HGNC cytogenetic band: 5q13.2ZBED3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M076367: view genomic region
(about GC identifiers)
Start:
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76,367,897 bp from pter |
End:
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76,383,148 bp from pter |
Size:
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15,252 bases |
Orientation:
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minus strand |
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Proteins
for ZBED3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZBED3_HUMAN, Q96IU2 (See
protein sequence)Recommended Name: Zinc finger BED domain-containing protein 3 Size: 234 amino acids; 25132 Da
Subunit: Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1Eactivities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations (By similarity)
Subcellular location: Cytoplasm (By similarity). Membrane (By similarity). Note=Colocalizes with AXIN1 in the cytoplasm(By similarity)Explore the universe of human proteins at neXtProt for ZBED3: NX_Q96IU2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IU2
ZBED3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115743.1
ENSEMBL proteins: ENSP00000255198 ENSP00000427487
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZBED3 for ontologies About GeneDecksing
ZBED3 Antibody Products:
Assay Products for ZBED3: |
Protein
Domains /
Families
for ZBED3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZBED3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96IU2ProtoNet protein and cluster: Q96IU2 UniProtKB/Swiss-Prot: ZBED3_HUMAN, Q96IU2Similarity: Contains 1 BED-type zinc finger |
Function
for ZBED3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZBED3_HUMAN, Q96IU2Function: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway bystabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZBED3 (NM_032367) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBED3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBED3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZBED3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZBED3:
|
Pathways & Interactions
for ZBED3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBED3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZBED3 (ENSP000002551984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001933 | negative regulation of protein phosphorylation |
ISS | -- | | GO:0016055 | Wnt receptor signaling pathway |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0050821 | protein stabilization |
ISS | -- | | GO:0090263 | positive regulation of canonical Wnt receptor signaling pathway |
ISS | -- |
ZBED3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZBED3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZBED3
Search CenterWatch for drugs/clinical trials and news about ZBED3
|
Transcripts
for ZBED3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZBED3 gene: NM_032367.2 Unigene Cluster for ZBED3: Zinc finger, BED-type containing 3 Hs.584988 [show with all ESTs]Unigene Representative Sequence: BU5705093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000255198(uc003kev.1) ENST00000511587 ENST00000505685
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZBED3 (NM_032367) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBED3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBED3 |
Additional cDNA sequence: AK223624.1 BC007239.1 1 DOTS entry: DT.454885 24/95 AceView cDNA sequences (see all 95): CD674177 AI810713 BC007239 NM_032367 BU521064 CB119841 BM750164 AA568943 CA449845 AI573007 AA311214 AI421730 BM741545 AI522237 BE302693 BM727024 AW301709 AI355755 AI399944 AI810967 BI964860 BG753017 AI679528 AI241332
GeneLoc Exon Structure
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Expression
for ZBED3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZBED3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTATACA
About this image
See ZBED3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZBED3
SOURCE GeneReport for Unigene cluster: Hs.584988
SABiosciences Custom PCR Arrays for ZBED3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBED3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZBED3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBED3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBED3 |
Orthologs
for ZBED3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZBED3 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZBED3 (if available)
TreeFam Gene Tree for ZBED3 (if available) |
Paralogs
for ZBED3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZBED3 gene
- ZBED22
1 SIMAP similar gene for ZBED3 using alignment to 3 protein entries: ZBED3_HUMAN (see all proteins):ZBED2
ZBED3 for paralogs About GeneDecksing
|
Genomic Variants
for ZBED3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZBED3 (76367897 - 76383148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZBED3
1 Indel: 69150 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBED3 |
|
Disorders
/ Diseases
for ZBED3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ZBED3 for disorders About MalaCards
ZBED3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: ZBED3 (5 documents)
Export disorders for ZBED3 gene to outside databases
|
Publications
for ZBED3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZBED3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZBED3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1 Voight B.F.... . (2010)
- Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide pol ymorphisms. (PubMed id 20889853)1 de Miguel-Yanes J.M....Meigs J.B. (2010)
- Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. (PubMed id 19141611)1 Chen T....Li L. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for ZBED3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZBED3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZBED3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZBED3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZBED3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZBED3 gene:
Search GeneIP for patents involving ZBED3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZBED3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ZBED3 | | OriGene shRNA RFP for ZBED3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZBED3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZBED3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZBED3 | | OriGene 3'-UTR Clone for ZBED3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZBED3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZBED3 | | OriGene Custom Protein Services for ZBED3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBED3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZBED3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBED3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZBED3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZBED3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZBED3 |
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| | | | Search Tocris compounds for ZBED3 |
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 | | | ZBED3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for ZBED3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZBED3 |
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