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Aliases for ZBED3 Gene

Aliases for ZBED3 Gene

  • Zinc Finger BED-Type Containing 3 2 3 5
  • Axin-Interacting Protein 3 4
  • Zinc Finger BED Domain-Containing Protein 3 3
  • Zinc Finger, BED Domain Containing 3 3
  • 2610005H11Rik 3

External Ids for ZBED3 Gene

Previous GeneCards Identifiers for ZBED3 Gene

  • GC05M076606
  • GC05M076411
  • GC05M076456
  • GC05M076408
  • GC05M076367
  • GC05M071579

Summaries for ZBED3 Gene

Entrez Gene Summary for ZBED3 Gene

  • This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung cancer tissues, where the encoded protein causes an accumulation of beta-catenin and enhanced lung cancer cell invasion. In addition, the encoded protein can be secreted and be involved in resistance to insulin. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZBED3 Gene

ZBED3 (Zinc Finger BED-Type Containing 3) is a Protein Coding gene. An important paralog of this gene is ZBED2.

UniProtKB/Swiss-Prot for ZBED3 Gene

  • Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED3 Gene

Genomics for ZBED3 Gene

Regulatory Elements for ZBED3 Gene

Enhancers for ZBED3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F077085 1 ENCODE 0.8 +0.3 252 2.8 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ZNF2 YY1 SLC30A9 GLIS2 ZNF207 ZBED3-AS1 ZBED3
GH05F077133 1 Ensembl ENCODE 0.2 -45.9 -45878 0.4 JUN INSM2 SIN3A ZNF366 SCRT2 ZNF600 FOS MAFK TCF7L2 NFE2L2 HMGB1P35 ZBED3
GH05F077126 0.6 FANTOM5 0.3 -39.2 -39191 0.4 ATF3 NFIA HNF4G ZBTB33 RAD21 HMGB1P35 ZBED3
GH05F077139 0.6 Ensembl 0.2 -51.9 -51878 0.4 NR3C1 ZIC2 ZKSCAN8 GLIS1 HMBOX1 ETV6 SP7 ZNF558 ZBTB20 PDE8B HMGB1P35 ZBED3
GH05F077145 0.6 Ensembl 0.2 -58.8 -58778 1.0 JUND GATA2 ZNF366 JUN MAX ATF2 PDE8B ZBED3-AS1 SNORA47 WDR41 HMGB1P35 ZBED3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZBED3 on UCSC Golden Path with GeneCards custom track

Promoters for ZBED3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001283407 123 2401 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SLC30A9 GLIS2 ZNF207 KLF7

Genomic Location for ZBED3 Gene

Chromosome:
5
Start:
77,072,072 bp from pter
End:
77,087,323 bp from pter
Size:
15,252 bases
Orientation:
Minus strand

Genomic View for ZBED3 Gene

Genes around ZBED3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED3 Gene

Proteins for ZBED3 Gene

  • Protein details for ZBED3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IU2-ZBED3_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 3
    Protein Accession:
    Q96IU2

    Protein attributes for ZBED3 Gene

    Size:
    234 amino acids
    Molecular mass:
    25132 Da
    Quaternary structure:
    • Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.

neXtProt entry for ZBED3 Gene

Post-translational modifications for ZBED3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZBED3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZBED3 Gene

Domains & Families for ZBED3 Gene

Gene Families for ZBED3 Gene

Protein Domains for ZBED3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBED3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96IU2

UniProtKB/Swiss-Prot:

ZBED3_HUMAN :
  • Contains 1 BED-type zinc finger.
Similarity:
  • Contains 1 BED-type zinc finger.
genes like me logo Genes that share domains with ZBED3: view

Function for ZBED3 Gene

Molecular function for ZBED3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity).

Gene Ontology (GO) - Molecular Function for ZBED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBED3: view
genes like me logo Genes that share phenotypes with ZBED3: view

Animal Model Products

miRNA for ZBED3 Gene

miRTarBase miRNAs that target ZBED3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBED3 Gene

Localization for ZBED3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBED3 Gene

Cytoplasm. Membrane. Note=Colocalizes with AXIN1 in the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZBED3 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ZBED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,ISS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with ZBED3: view

Pathways & Interactions for ZBED3 Gene

SuperPathways for ZBED3 Gene

No Data Available

Interacting Proteins for ZBED3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000255198%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000255198 Q96IU2-ZBED3_HUMAN for ZBED3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ZBED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0016055 Wnt signaling pathway IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,ISS --
GO:0050821 protein stabilization IEA,ISS --
GO:0090263 positive regulation of canonical Wnt signaling pathway IEA,ISS --
genes like me logo Genes that share ontologies with ZBED3: view

No data available for Pathways by source and SIGNOR curated interactions for ZBED3 Gene

Transcripts for ZBED3 Gene

mRNA/cDNA for ZBED3 Gene

Unigene Clusters for ZBED3 Gene

Zinc finger, BED-type containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED3 Gene

No ASD Table

Relevant External Links for ZBED3 Gene

GeneLoc Exon Structure for
ZBED3
ECgene alternative splicing isoforms for
ZBED3

Expression for ZBED3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZBED3 Gene

Protein differential expression in normal tissues from HIPED for ZBED3 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZBED3 Gene



Protein tissue co-expression partners for ZBED3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZBED3 Gene:

ZBED3

SOURCE GeneReport for Unigene cluster for ZBED3 Gene:

Hs.584988
genes like me logo Genes that share expression patterns with ZBED3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZBED3 Gene

Orthologs for ZBED3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZBED3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBED3 34
  • 86.1 (n)
mouse
(Mus musculus)
Mammalia Zbed3 34 16 35
  • 68.48 (n)
rat
(Rattus norvegicus)
Mammalia Zbed3 34
  • 68.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
Species where no ortholog for ZBED3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZBED3 Gene

ENSEMBL:
Gene Tree for ZBED3 (if available)
TreeFam:
Gene Tree for ZBED3 (if available)

Paralogs for ZBED3 Gene

Paralogs for ZBED3 Gene

(1) SIMAP similar genes for ZBED3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZBED3: view

Variants for ZBED3 Gene

Sequence variations from dbSNP and Humsavar for ZBED3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1056586 -- 77,077,025(-) CACAC(C/T)CTAAG utr-variant-3-prime
rs1056587 -- 77,076,884(-) GAGCT(C/T)CAGGA utr-variant-3-prime
rs111747286 -- 77,085,029(+) CATGC(C/T)TCTGC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111898526 -- 77,086,719(+) CGACA(C/T)CAAGC intron-variant, upstream-variant-2KB
rs112242545 -- 77,088,988(+) TACAA(C/T)AATAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZBED3 Gene

Variant ID Type Subtype PubMed ID
esv29310 CNV loss 19812545
nsv823102 CNV gain 20364138
nsv4886 CNV insertion 18451855
nsv469515 CNV loss 16826518
nsv1145065 CNV deletion 24896259
nsv1027236 CNV gain 25217958

Variation tolerance for ZBED3 Gene

Gene Damage Index Score: 7.44; 81.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBED3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZBED3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZBED3 Gene

Disorders for ZBED3 Gene

Relevant External Links for ZBED3

Human Genome Epidemiology (HuGE) Navigator
ZBED3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED3

No disorders were found for ZBED3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBED3 Gene

Publications for ZBED3 Gene

  1. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Zbed3 contributes to malignant phenotype of lung cancer via regulating I^-catenin and P120-catenin 1. (PMID: 25263389) Fan C. … Wang E. (Mol. Carcinog. 2015) 3 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3 64

Products for ZBED3 Gene

Sources for ZBED3 Gene

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