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ZBED2 Gene

protein-coding   GIFtS: 43

GC03M112794
zinc finger, BED-type containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for ZBED2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC10796 1, 2
OTTHUMP00000082693 2
Descriptions
zinc finger, BED domain containing 2 2
zinc finger, BED-type containing 2 2
External Ids
HGNC: 207101
Entrez Gene: 794132
UniProtKB: Q9BTP63
Ensembl: ENSG000001774947
Search outside databases for aliases for ZBED2 gene

Previous GC identifers: GC03M110882 GC03M112593 GC03M112632

Summaries
for ZBED2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for ZBED2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ZBED2 gene  

Entrez Gene cytogenetic band: 3q13.13   Ensembl cytogenetic band:  3q13.13   HGNC cytogenetic band: 3p13-q13.2

ZBED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112794:     (about GC identifiers)

Start:
 112,794,437 bp from pter
End:
 112,796,856 bp from pter
Size:
 2,420 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  

Proteins
for ZBED2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ZBED2_HUMAN, Q9BTP6 (See protein sequence)
Recommended Name: Zinc finger BED domain-containing protein 2  
Size: 217 amino acids; 24991 Da
PDB structures from and Proteopedia :
2DJR (3D)    

REFSEQ proteins: NP_078784.2  

ENSEMBL proteins: 
ENSP00000321370 ENSP00000373183 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ZBED2)
Human Recombinant Proteins from Abnova (ZBED2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for ZBED2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (ZBED2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ZBED2)
Novus Biologicals Antibody for ZBED2

Assays for ZBED2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for ZBED2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR003656 Znf_BED_prd


   GeneDecks  ZBED2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9BTP6

ProtoNet protein and cluster: Q9BTP6

1 Blocks protein family: IPB000515 Binding-protein-dependent transport systems inner membrane component

UniProtKB/Swiss-Prot: ZBED2_HUMAN, Q9BTP6
Similarity: Contains 1 BED-type zinc finger

Gene Function
for ZBED2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (ZBED2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBED2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024508

              Applied Biosystems Silencer® siRNAs for ZBED2

              Sigma-Aldrich siRNA for ZBED2  
                     Sigma-Aldrich shRNA for ZBED2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ZBED2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024508
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024508
                                 untagged cDNA clone in CMV expression vector: NM_024508 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_024508

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

Pathways & Interactions
for ZBED2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for ZBED2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBED2

Transcripts
for ZBED2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (ZBED2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ZBED2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024508

              Sigma-Aldrich siRNA for ZBED2  
                     Sigma-Aldrich shRNA for ZBED2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_024508  

REFSEQ mRNAs for ZBED2 gene: 

NM_024508.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_024508  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024508
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024508
                                 untagged cDNA clone in CMV expression vector: NM_024508 

Additional cDNA sequence: 

BC003536.1 BC071956.1 

1 DOTS entry:

DT.434233 

24/28 AceView cDNA sequences (see all 28 ):

AI813590 BQ878850 BC071956 AW575079 BC003536 CA440278 BM990943 NM_024508 
AA810929 AI582219 D78844 AW104256 AA830718 BG232007 AA923758 AW575241 
AW402886 CN479204 AW402327 BE746513 CD632045 BM847001 BE898283 BE740032 

highest scoring ESTs for ZBED2:

BE898283 D78844 AA729527 AA810929 AA830718 AA923758 AI582219 AI813590 AI924459 AW104256 

Unigene Cluster for ZBED2:

Zinc finger, BED-type containing 2
Hs.136912  [show with all ESTs]
Unigene Representative Sequence: NM_024508


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000317012  ENST00000383685  

Expression
for ZBED2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBED2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBED2

1 / 2 / 3

3 probe-sets matching ZBED2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
82434_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 AI924459 0.60 1.00 0.82 1

219836_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024508 0.60 1.00 0.82 1

219836_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  ZBED2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TACTGGTGGA

SOURCE GeneReport for Unigene cluster: Hs.136912

Orthologs
for ZBED2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for ZBED2 gene from 3 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 ZBED21   -- zinc finger, BED-type containing 2 86.79(n)
90.32(a)		 487971  XM_545093.1  XP_545093.1 
chimpanzee
(Pan troglodytes)		 ZBED21   -- zinc finger, BED-type containing 2 98.93(n)
98.62(a)		 742842  XM_001152879.1  XP_001152879.1 
cow
(Bos taurus)		 ZBED21   -- zinc finger, BED-type containing 2 86.02(n)
86.64(a)		 539880  XM_590046.2  XP_590046.1 
About this table        Species with no ortholog for ZBED2

ENSEMBL Gene Tree for ZBED2

Paralogs
for ZBED2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ZBED2 gene
ZBED32  

SNPs/Variants
for ZBED2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for ZBED2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for ZBED2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for ZBED2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for ZBED2 gene:

Search for ZBED2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing ZBED2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 79413 HGNC: 20710 AceView: ZBED2 Ensembl:ENSG00000177494 euGenes: HUgn79413
ECgene: ZBED2 H-InvDB: ZBED2

Other Databases showing ZBED2

(According to HUGE)
About This Section

   --

Specialized Databases showing ZBED2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for ZBED2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for ZBED2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBED2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBED2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for ZBED2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ZBED2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(ZBED2)
 Antibodies (ZBED2)
 Search OriGene for ZBED2
 Search Tocris compounds for ZBED2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for ZBED2

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