V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ZBED1 Gene

protein-coding GIFtS: 47

GC0XM002320

zinc finger, BED-type containing 1
(Previous name: Ac-like transposable element )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ALTE)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALTE ^², ³, ⁵
DREF ^¹, ², ³
KIAA0785 ^¹, ², ³, ⁵
OTTHUMP00000022839 ^²
OTTHUMP00000070388 ^²
TRAMP ^¹, ², ³, ⁵
hDREF ^¹, ²

Descriptions
Ac-like transposable element ^¹, ²
DNA replication-related element binding factor ^²
Putative Ac-like transposable element ^³
dREF homolog ^³
putative Ac-like transposon ^²
zinc finger, BED domain containing 1 ^²
zinc finger, BED-type containing 1 ^²

External Ids
HGNC: 447¹
Entrez Gene: 9189²
UniProtKB: O96006³
Ensembl: ENSG00000214717⁷

Search outside databases for aliases for ZBED1 gene

Previous GC identifers: GC0XM001999 GC0YM002320 GC0XM002148

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006

Function: Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of

genes related to cell proliferation. Binds to the histone H1 promoter and stimulates

transcription. Was first identified as gene weakly similar to Ac transposable elements, but does

not code for any transposase activity

Gene Wiki entry for ZBED1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33;Yp11 Ensembl cytogenetic band: Xp22.33 HGNC cytogenetic band: Xp22.33 and Yp11

ZBED1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM002320: (about GC identifiers)

Start:	2,414,455 bp from pter
End:	2,429,008 bp from pter
Size:	14,554 bases
Orientation:	minus strand

1 alternative location:

ChrY- 2,414,455-2,429,008

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006 (See protein sequence)

Recommended Name: Zinc finger BED domain-containing protein 1

Size: 694 amino acids; 78156 Da

Subunit: Homodimer (Potential)

Subcellular location: Nucleus. Note=In granular structures

Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1)

of X and Y chromosomes

PDB structures from and Proteopedia :

2CT5 (3D)

Secondary accessions: Q96BY4

REFSEQ proteins: NP_004720.1

ENSEMBL proteins:

ENSP00000370616 ENSP00000370620

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DREF)
	Human Recombinant Proteins from Abnova (ZBED1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	TAS	9887332
GO:0005634	nucleus	IEA	--

About this table

Antibodies for ZBED1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZBED1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DREF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZBED1)
	Novus Biologicals Antibodies for ZBED1

Assays for ZBED1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O96006

ProtoNet protein and cluster: O96006

1 Blocks protein family: IPB008906 HAT dimerisation

UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006

Similarity: Contains 1 BED-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBED1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBED1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004729

Applied Biosystems Silencer® siRNAs for ZBED1

Sigma-Aldrich siRNA for ZBED1

Sigma-Aldrich shRNA for ZBED1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZBED1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004729
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004729
untagged cDNA clone in CMV expression vector: NM_004729

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004729

UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006

Function: Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of

genes related to cell proliferation. Binds to the histone H1 promoter and stimulates

transcription. Was first identified as gene weakly similar to Ac transposable elements, but does

not code for any transposase activity

Induction: Expression is linked to the cell cycle: low in serum-starved fibroblasts, increasing

during the G1/S phase, highest during the S/G2 phase and then decreasing again

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004803	transposase activity	TAS	9887332
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/17 Interacting proteins for ZBED1 (O96006² ENSP00000370620³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FANCG	O15287²	MINT-66922
GPN1	Q9HCN4²	MINT-66624
GPSM1	Q86YR5²	MINT-67402
NIP7	Q9Y221²	MINT-67408
NUDT18	Q6ZVK8²	MINT-67371

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBED1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZBED1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZBED1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004729

Sigma-Aldrich siRNA for ZBED1

Sigma-Aldrich shRNA for ZBED1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004729

REFSEQ mRNAs for ZBED1 gene:

NM_004729.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004729

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004729
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004729
                                 untagged cDNA clone in CMV expression vector: NM_004729

24/192 AceView cDNA sequences (see all 192 ):

AW196831 BQ674932 CR613724 BM837900 BU509734 BM549506 AV655439 CR597100

AA302814 BE269286 BF940271 AI752969 AI494595 BE899456 AL705875 M78108

AI682592 BQ669498 AI962736 AI493774 BQ671861 BE886788 BX107641 AW135244

highest scoring ESTs for ZBED1:

AA216160 AA496808 BE296471 BE741290 BF837834 BG386894 BI114791 BM788079 BM907310 BQ062092

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000381218 ENST00000381222

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBED1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZBED1

¹ / ² / ³

5 probe-sets matching ZBED1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39168_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.94	AB018328	0.80	0.70	0.75	1
44978_at²^{, 3}	U95-B	1	1.00	1.00	0.98	1.06	AI979194	0.40	0.67	0.55	1
203043_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004729	0.40	0.67	0.55	1
203043_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554821_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAGAACTGCT
Expression variation in blood from EXPOLDB for ZBED1
UniProtKB/Swiss-Prot: ZBED1_HUMAN, O96006
Tissue specificity: Ubiquitously expressed at low levels. Expression is highest in skeletal muscle,
heart, spleen and placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZBED1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZBED1¹	--	zinc finger, BED-type containing 1	87.9(n) 89.48(a)	491715 XM_548835.2 XP_548835.2
chimpanzee (Pan troglodytes)	ZBED1¹	--	zinc finger, BED-type containing 1	76.37(n) 62.03(a)	471273 XM_001137235.1 XP_001137235.1
cow (Bos taurus)	ZBED1¹	--	zinc finger, BED-type containing 1	84.25(n) 81.56(a)	539266 XM_586037.3 XP_586037.3
chicken (Gallus gallus)	ZBED1¹	--	zinc finger, BED-type containing 1	74.46(n) 84.13(a)	418663 XM_416859.2 XP_416859.1
zebrafish (Danio rerio)	LOC794597¹	--	similar to ZBED1 protein	42.48(n) 29.03(a)	794597 XM_001334552.1 XP_001334588.1

About this table Species with no ortholog for ZBED1

ENSEMBL Gene Tree for ZBED1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZBED1 gene

ZBED4²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300178

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/46 PubMed articles for ZBED1 gene (see all 46 ):

A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases. (PubMed id 9887332)^{1, 2, 3, 4} Esposito T....Forabosco A. (1999)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{2, 3, 4} Nagase T....Ohara O. (1998)
Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene. (PubMed id 12663651)^{1, 3, 4} Ohshima N.... Hirose F. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
hDREF regulates cell proliferation and expression of ribosomal protein genes. (PubMed id 17220279)^{1, 3} Yamashita D....Hirose F. (2007)
Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding. (PubMed id 17209048)³ Yamashita D....Hirose F. (2007)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)³ Lim J....Zoghbi H.Y. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)⁴ Ross M.T.... Bentley D.R. (2005)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9189	HGNC: 447	AceView: ZBED1.1	Ensembl:ENSG00000214717	euGenes: HUgn9189
ECgene: ZBED1	H-InvDB: ZBED1

(According to HUGE)
About This Section

HUGE: KIAA0785

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ZBED1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZBED1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZBED1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZBED1		Antibodies for ZBED1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZBED1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZBED1)
	Antibodies (ZBED1)
	Chimera RNAi (ZBED1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (DREF)
	Antibodies (DREF)

Search OriGene for ZBED1

Search Tocris compounds for ZBED1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ZBED1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ZBED1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ZBED1 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for ZBED1

Summaries
for ZBED1

Genomic Location
for ZBED1

Proteins
for ZBED1

Protein Domains/
Families
for ZBED1

Gene Function
for ZBED1

Pathways & Interactions
for ZBED1

Drugs & Compounds
for ZBED1

Transcripts
for ZBED1

Expression
for ZBED1

Orthologs
for ZBED1

Paralogs
for ZBED1

SNPs/Variants
for ZBED1

Disorders & Mutations
for ZBED1

Medical News
for ZBED1

Publications
for ZBED1

Search for ZBED1

Genome Databases showing ZBED1

Other Databases showing ZBED1

Specialized Databases showing ZBED1

Licensable Technologies
for ZBED1

Services
for ZBED1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZBED1 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor ZBED1

Summariesfor ZBED1

Genomic Locationfor ZBED1

Proteinsfor ZBED1

Protein Domains/Familiesfor ZBED1

Gene Functionfor ZBED1

Pathways & Interactionsfor ZBED1

Drugs & Compoundsfor ZBED1

Transcriptsfor ZBED1

Expression for ZBED1

Orthologsfor ZBED1

Paralogsfor ZBED1

SNPs/Variantsfor ZBED1

Disorders & Mutationsfor ZBED1

Medical Newsfor ZBED1

Publicationsfor ZBED1

Search for ZBED1

Genome Databases showing ZBED1

Other Databases showing ZBED1

Specialized Databases showing ZBED1

Licensable Technologiesfor ZBED1

Servicesfor ZBED1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZBED1

Summaries
for ZBED1

Genomic Location
for ZBED1

Proteins
for ZBED1

Protein Domains/
Families
for ZBED1

Gene Function
for ZBED1

Pathways & Interactions
for ZBED1

Drugs & Compounds
for ZBED1

Transcripts
for ZBED1

Expression
for ZBED1

Orthologs
for ZBED1

Paralogs
for ZBED1

SNPs/Variants
for ZBED1

Disorders & Mutations
for ZBED1

Medical News
for ZBED1

Publications
for ZBED1

Licensable Technologies
for ZBED1

Services
for ZBED1