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ZBBX Gene

protein-coding   GIFtS: 38

GC03M168440
zinc finger, B-box domain containing
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ23049 1, 2
OTTHUMP00000164931 2
Descriptions
zinc finger, B-box domain containing 2
External Ids
HGNC: 262451
Entrez Gene: 797402
UniProtKB: A8MT703
Ensembl: ENSG000001690647
Search outside databases for aliases for ZBBX gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1   Ensembl cytogenetic band:  3q26.1   HGNC cytogenetic band: 3q26.1

ZBBX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M168440:     (about GC identifiers)

Start:
168,440,769 bp from pter
End:
168,580,765 bp from pter
Size:
139,997 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZBBX_HUMAN, A8MT70 (See protein sequence)
Recommended Name: Zinc finger B-box domain containing protein 1  
Size: 800 amino acids; 91426 Da
Secondary accessions: A8MV69 B3KSC1 Q9H5T8
Alternative splicing: 2 isoforms:  A8MT70-1   A8MT70-2   

REFSEQ proteins: NP_078963.2  

ENSEMBL proteins: 
ENSP00000376520 ENSP00000376519 ENSP00000376517 ENSP00000305065 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
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Antibodies for ZBBX: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for ZBBX

Assays for ZBBX: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR000315 Znf_B-box


   GeneDecks  ZBBX for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A8MT70

ProtoNet protein and cluster: A8MT70

UniProtKB/Swiss-Prot: ZBBX_HUMAN, A8MT70
Similarity: Contains 1 B box-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBBX)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FLJ23049)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024687

              Applied Biosystems Silencer® siRNAs for ZBBX

              Sigma-Aldrich siRNA for ZBBX  
                     Sigma-Aldrich shRNA for ZBBX  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024687
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024687
                                 untagged cDNA clones in CMV expression vector (see all 3): AK093296 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_024687

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008270 zinc ion binding IEA--
GO:0046872 metal ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZBBX

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ZBBX)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FLJ23049)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024687

              Sigma-Aldrich siRNA for ZBBX  
                     Sigma-Aldrich shRNA for ZBBX  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_024687  

REFSEQ mRNAs for ZBBX gene: 

NM_024687.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_024687  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024687
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024687
                                 untagged cDNA clones in CMV expression vector (see all 3): AK093296 

Additional cDNA sequence: 

AK026702.1 AK093296.1 BC034229.1 BC144444.1 

10 DOTS entries:

DT.109670  DT.120897114  DT.100752081  DT.100752082  DT.120897125  DT.95257285  DT.95313234  DT.100022036 
DT.100022037  DT.91730265 

24/53 AceView cDNA sequences (see all 53 ):

BM927090 BU674688 CB321707 BM979266 CA312790 AW663441 AA398571 AA922191 
AA348419 CD103788 CA314860 BC034229 AI023584 BV204591 AA725496 AW197827 
AI636208 AX748039 AW070998 AK026702 CB243818 AI221656 NM_024687 AI219735 

Unigene Cluster for ZBBX:

Zinc finger, B-box domain containing
Hs.478143  [show with all ESTs]
Unigene Representative Sequence: NM_024687


GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:
ENST00000392767  ENST00000392766  ENST00000392764  ENST00000307529  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZBBX expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ZBBX

1 / 2

3 probe-sets matching ZBBX gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
47594_at2 U95-B 2 1.00 0.97 1.00 1.00 -- -- -- -- --

220269_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

220269_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  ZBBX for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TCATCACACT

SOURCE GeneReport for Unigene cluster: Hs.478143
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ZBBX gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ZBBX1   -- zinc finger, B-box domain containing 83.44(n)
73.96(a)
478683  XM_535852.2  XP_535852.2 
chimpanzee
(Pan troglodytes)
ZBBX1   -- zinc finger, B-box domain containing 99(n)
97.62(a)
743482  XM_001159867.1  XP_001159867.1 
cow
(Bos taurus)
ZBBX1   -- zinc finger, B-box domain containing 82.45(n)
70.91(a)
616855  XM_868975.2  XP_874068.2 
rat
(Rattus norvegicus)
Zbbx1   -- zinc finger, B-box domain containing 72.3(n)
58.1(a)
361964  NM_001029922.1  NP_001025093.1 
mouse
(Mus musculus)
Zbbx1, 5 35
zinc finger, B-box domain containing1, 5 74(n)1
57.63(a)1
2132341  NM_172515.21  NP_766103.21 
 AK0298995  AK1331025  (see all 7)
About this table        Species with no ortholog for ZBBX

ENSEMBL Gene Tree for ZBBX
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/643 NCBI SNPs in ZBBX are shown (see all 643 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 178)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs126386251,2
A,C,F,H168482950(+) AATTTG/CCTGTT 1 G/A mis1 ese313Minor allele frequency- C:0.44EU EA WA NA 1264
rs46197841,2
A,C,F,H168550950(+) TGAACT/ATTAGC 1 N/K mis18Minor allele frequency- A:0.23EU EA WA 840
rs119230541,2
A,C,F,H168534463(+) GAGATT/CTTGCC 1 R/K mis110Minor allele frequency- C:0.22EU EA WA 1014
rs98691991,2
C,F,H168581621(+) CATTAC/GTTTTG 1 -- ng318Minor allele frequency- G:0.44EU EA WA 838
rs130967671,2
C,F,H168506432(+) TTTCTG/CCTGTT 1 G/A mis18Minor allele frequency- C:0.32EU EA WA 840
rs358645451,2
C,F168506187(-) CCTTGG/AAATTG 1 K/E mis15Minor allele frequency- A:0.04NA EU EA WA 494
rs109365351,2
C,H168573344(+) TCCAGG/TTTTTC 1 P/T mis14Minor allele frequency- T:0.00EU EA WA 418
rs351909251,2
C,F168506318(-) AAATAT/CAGGTT 1 T/I mis15Minor allele frequency- C:0.04NA EU EA WA 492
rs43450651,2
C168440861(+) AGTGTA/GATTAT 1 -- ut310--------
--
rs130652871,2
A168582064(+) AGAACA/TAGTTT 1 -- ng310--------
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HapMap Linkage Disequilibrium images for ZBBX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for ZBBX gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79740 HGNC: 26245 AceView: FLJ23049 Ensembl:ENSG00000169064 euGenes: HUgn79740
ECgene: ZBBX H-InvDB: ZBBX
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ZBBX:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ZBBX-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for ZBBX Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ZBBX Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search OriGene for ZBBX
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 Search Novus for antibodies for ZBBX

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