ZBBX Gene
protein-coding GIFtS : 41
GCID: GC03 M166958
zinc finger, B-box domain containing
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Aliasesfor ZBBX gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger, B-Box Domain Containing 1 2 FLJ230491 Zinc Finger B-Box Domain-Containing Protein 12
Export aliases for ZBBX gene to outside databases Previous GC identifers: GC03M168440 GC03M164328
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Summariesfor ZBBX gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor ZBBX gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_005612.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZBBX gene promoter: HFH-3 TBP CUTL1 NF-E2 p45 FOXL1 FOXI1 FAC1 TFIID FOXO1a NF-E2 Other transcription factors Search SABiosciences Chromatin IP Primers for ZBBX Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBBX
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q26.1 Ensembl cytogenetic band: 3q26.1 HGNC cytogenetic band: 3q26.1 ZBBX Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M166958: view genomic region
(about GC identifiers )
Start:
166,958,075 bp from pter
End:
167,099,134 bp from pter
Size:
141,060 bases
Orientation:
minus strand
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Proteinsfor ZBBX gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZBBX_HUMAN, A8MT70 (See
protein sequence )Recommended Name: Zinc finger B-box domain-containing protein 1 Size : 800 amino acids; 91426 Da
Sequence caution : Sequence=BAB15532.1; Type=Erroneous initiation;
Secondary accessions : A8MV69 B3KSC1 B5MDJ6 Q9H5T8Alternative splicing : 2 isoforms : A8MT70-1 A8MT70-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZBBX: NX_A8MT70 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A8MT70 ZBBX Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001186130.1 NP_001186131.1 NP_078963.2 ENSEMBL proteins: ENSP00000376519 ENSP00000390232 ENSP00000417678 ENSP00000418861 ENSP00000376517 ENSP00000419264 ENSP00000419307 ENSP00000417088 ENSP00000376520 ENSP00000305065 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA --
ZBBX for ontologies About GeneDecksing ZBBX Antibody Products: Assay Products for ZBBX:
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Protein
Domains / Familiesfor ZBBX gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZBBX for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry A8MT70 ProtoNet protein and cluster: A8MT70
UniProtKB/Swiss-Prot: ZBBX_HUMAN, A8MT70 Similarity : Contains 1 B box-type zinc finger
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Functionfor ZBBX gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZBBX (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZBBXOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ZBBX (NM_024687 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBBX Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZBBX
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBBX
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008270 zinc ion binding
IEA --
ZBBX for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ZBBX :
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Pathways & Interactionsfor ZBBX gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZBBX
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Drugs & Compoundsfor ZBBX gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZBBX Search CenterWatch for drugs/clinical trials and news about ZBBX
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Transcriptsfor ZBBX gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZBBX gene (3 alternative transcripts): NM_001199201.1 NM_001199202.1 NM_024687.3 Unigene Cluster for ZBBX:
Zinc finger, B-box domain containing Hs.478143 [show with all ESTs ] Unigene Representative Sequence: NM_001199201 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000392766 (uc011bpc.2 uc003feq.3 uc003fep.3 ) ENST00000455345 ENST00000494898 ENST00000492642 ENST00000392764 ENST00000464922 ENST00000465071 ENST00000469220 ENST00000474464 ENST00000485651 ENST00000473888 ENST00000392767 ENST00000307529 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZBBX (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZBBXOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ZBBX (NM_024687 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZBBX Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZBBX
Additional cDNA sequence: AK026702.1 AK093296.1 BC034229.1 BC144444.1
10 DOTS entries : DT.109670 DT.120897114
DT.100752081 DT.100752082 DT.120897125 DT.95257285 DT.95313234 DT.100022036 DT.100022037 DT.91730265 24/53 AceView cDNA sequences (see all 53 ):
CB321707 AA398571 AA922191 CA312790 CD103788 AW663441 BU674688 AA348419 BM927090 BM979266 CN478727 AW181926 AK026702 AW628213 NM_024687 AI636208 AI219735 BX956295 AA725496 BC034229 CN478675 AW197827 CB243818 AX748039 GeneLoc Exon Structure
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Expression for ZBBX gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZBBX expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCATCACACT
About this image ZBBX expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ZBBX Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZBBX SOURCE GeneReport for Unigene cluster: Hs.478143 SABiosciences Custom PCR Arrays for ZBBX Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZBBXBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZBBX QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZBBX QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZBBX In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBBX
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Orthologsfor ZBBX gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ZBBX gene from 3/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for ZBBX (if available)TreeFam Gene Tree for ZBBX (if available)
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Paralogsfor ZBBX gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor ZBBX gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZBBX (166958075 - 167099134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZBBX: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZBBX
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Disorders
/ Diseasesfor ZBBX gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section ZBBX for disorders About MalaCards
ZBBX for disorders About GeneDecksing 1 disease from the University of Copenhagen DISEASES database for ZBBX :Attention deficit hyperactivity disorder Export disorders for ZBBX gene to outside databases
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Publicationsfor ZBBX gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZBBX gene integrated from 9 sources : (articles sorted by number of sources associating them with ZBBX) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 2 Muzny D.M....Gibbs R.A. (2006) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for ZBBX gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZBBX gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZBBX gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZBBX gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZBBX Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZBBX gene: Search GeneIP for patents involving ZBBX GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZBBX gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZBBX OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZBBX OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZBBX OriGene Protein Over-expression Lysate for ZBBX Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for ZBBX OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZBBX OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZBBX Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ZBBX OriGene Custom Protein Services for ZBBX OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZBBX QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZBBX QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZBBX QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZBBX QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZBBX QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZBBX
Search Tocris compounds for ZBBX
ZBBX Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZBBX
ThermoFisher Antibody for ZBBX
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZBBX
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Intellectual Property for ZBBX
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