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Aliases for ZBBX Gene

Aliases for ZBBX Gene

  • Zinc Finger B-Box Domain Containing 2 3
  • Zinc Finger, B-Box Domain Containing 5

External Ids for ZBBX Gene

Previous GeneCards Identifiers for ZBBX Gene

  • GC03M168440
  • GC03M166958
  • GC03M164328

Summaries for ZBBX Gene

GeneCards Summary for ZBBX Gene

ZBBX (Zinc Finger B-Box Domain Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBBX Gene

Genomics for ZBBX Gene

Regulatory Elements for ZBBX Gene

Promoters for ZBBX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBBX on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBBX Gene

Chromosome:
3
Start:
167,178,425 bp from pter
End:
167,381,346 bp from pter
Size:
202,922 bases
Orientation:
Minus strand

Genomic View for ZBBX Gene

Genes around ZBBX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBBX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBBX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBBX Gene

Proteins for ZBBX Gene

  • Protein details for ZBBX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT70-ZBBX_HUMAN
    Recommended name:
    Zinc finger B-box domain-containing protein 1
    Protein Accession:
    A8MT70
    Secondary Accessions:
    • A8MV69
    • B3KSC1
    • B5MDJ6
    • F2Z370
    • Q9H5T8

    Protein attributes for ZBBX Gene

    Size:
    800 amino acids
    Molecular mass:
    91426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15532.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZBBX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZBBX Gene

Proteomics data for ZBBX Gene at MOPED

Post-translational modifications for ZBBX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZBBX Gene

Domains & Families for ZBBX Gene

Protein Domains for ZBBX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZBBX Gene

Graphical View of Domain Structure for InterPro Entry

A8MT70

UniProtKB/Swiss-Prot:

ZBBX_HUMAN :
  • Contains 1 B box-type zinc finger.
Similarity:
  • Contains 1 B box-type zinc finger.
genes like me logo Genes that share domains with ZBBX: view

No data available for Gene Families for ZBBX Gene

Function for ZBBX Gene

genes like me logo Genes that share phenotypes with ZBBX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZBBX Gene

Localization for ZBBX Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBBX Gene COMPARTMENTS Subcellular localization image for ZBBX gene
Compartment Confidence
nucleus 3
cytosol 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZBBX Gene

Pathways & Interactions for ZBBX Gene

SuperPathways for ZBBX Gene

No Data Available

Interacting Proteins for ZBBX Gene

Gene Ontology (GO) - Biological Process for ZBBX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBBX Gene

Drugs & Compounds for ZBBX Gene

No Compound Related Data Available

Transcripts for ZBBX Gene

Unigene Clusters for ZBBX Gene

Zinc finger, B-box domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZBBX Gene

No ASD Table

Relevant External Links for ZBBX Gene

GeneLoc Exon Structure for
ZBBX
ECgene alternative splicing isoforms for
ZBBX

Expression for ZBBX Gene

mRNA expression in normal human tissues for ZBBX Gene

mRNA differential expression in normal tissues according to GTEx for ZBBX Gene

This gene is overexpressed in Testis (x12.4), Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.4), and Fallopian Tube (x4.2).

Protein differential expression in normal tissues from HIPED for ZBBX Gene

This gene is overexpressed in Monocytes (37.3) and Ovary (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZBBX Gene



SOURCE GeneReport for Unigene cluster for ZBBX Gene Hs.478143

genes like me logo Genes that share expression patterns with ZBBX: view

Protein tissue co-expression partners for ZBBX Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZBBX Gene

Orthologs for ZBBX Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZBBX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBBX 36
  • 98 (a)
OneToOne
ZBBX 35
  • 98.97 (n)
  • 97.73 (a)
cow
(Bos Taurus)
Mammalia ZBBX 35
  • 83.12 (n)
  • 72.83 (a)
ZBBX 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBBX 36
  • 73 (a)
OneToOne
ZBBX 35
  • 84.71 (n)
  • 74.73 (a)
mouse
(Mus musculus)
Mammalia Zbbx 16
Zbbx 36
  • 56 (a)
OneToOne
Zbbx 35
  • 73.6 (n)
  • 56.86 (a)
oppossum
(Monodelphis domestica)
Mammalia ZBBX 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZBBX 36
  • 13 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zbbx 35
  • 73.48 (n)
  • 57.64 (a)
chicken
(Gallus gallus)
Aves ZBBX 36
  • 13 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBBX 36
  • 10 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zbbx 35
  • 53.55 (n)
  • 43.36 (a)
zebrafish
(Danio rerio)
Actinopterygii zbbx 36
  • 11 (a)
OneToOne
Species with no ortholog for ZBBX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZBBX Gene

ENSEMBL:
Gene Tree for ZBBX (if available)
TreeFam:
Gene Tree for ZBBX (if available)

Paralogs for ZBBX Gene

No data available for Paralogs for ZBBX Gene

Variants for ZBBX Gene

Sequence variations from dbSNP and Humsavar for ZBBX Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12638625 - 167,282,468(+) AATTT(A/C/G)CTGTT nc-transcript-variant, reference, missense
rs10936535 - 167,372,862(+) TCCAG(G/T)TTTTC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs4619784 - 167,350,468(+) TGAAC(A/T)TTAGC nc-transcript-variant, reference, missense
rs11923054 - 167,333,981(+) GAGAT(C/T)TTGCC nc-transcript-variant, reference, missense
rs13096767 - 167,305,950(+) TTTCT(A/C/G)CTGTT intron-variant, nc-transcript-variant, reference, missense

Variation tolerance for ZBBX Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.22; 98.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZBBX Gene

HapMap Linkage Disequilibrium report
ZBBX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZBBX Gene

Disorders for ZBBX Gene

Relevant External Links for ZBBX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBBX

No disorders were found for ZBBX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZBBX Gene

Publications for ZBBX Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for ZBBX Gene

Sources for ZBBX Gene

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