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Aliases for ZAR1L Gene

Aliases for ZAR1L Gene

  • Zygote Arrest 1-Like 2 3 5
  • Zinc Finger, 3CxxC-Type 7 2 3
  • ZAR1-Like Protein 3
  • Z3CXXC7 3
  • ZAR2 3

External Ids for ZAR1L Gene

Previous GeneCards Identifiers for ZAR1L Gene

  • GC13M031778
  • GC13M032877
  • GC13M013689

Summaries for ZAR1L Gene

Entrez Gene Summary for ZAR1L Gene

  • This gene encodes a member of the ZAR1 family that is predominantly expressed in oocytes and early embryos. The protein may function as an RNA regulator in early embryos. [provided by RefSeq, Apr 2010]

GeneCards Summary for ZAR1L Gene

ZAR1L (Zygote Arrest 1-Like) is a Protein Coding gene. An important paralog of this gene is ZAR1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAR1L Gene

Genomics for ZAR1L Gene

Regulatory Elements for ZAR1L Gene

Enhancers for ZAR1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F032340 0.2 Ensembl 12.9 -25.6 -25557 0.6 ZNF316 NFE2 NFE2L2 ZAR1L BRCA2 IFIT1P1
GH13F032205 0.7 FANTOM5 ENCODE 2.4 +109.1 109148 1.4 PRDM10 FRY FRY-AS1 ZAR1L GC13P032297 GC13P032060
GH13F032314 0.6 ENCODE 0.8 -0.4 -420 2.9 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 FOS BRCA2 N4BP2L2 ZAR1L IFIT1P1
GH13F032317 0.2 Ensembl 0.8 -2.6 -2557 0.2 ZNF146 CEBPB ZAR1L IFIT1P1
GH13F032318 0.2 Ensembl 0.8 -3.2 -3157 0.2 BRCA2 ZAR1L IFIT1P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZAR1L on UCSC Golden Path with GeneCards custom track

Promoters for ZAR1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054736 -456 2001 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for ZAR1L Gene

32,303,700 bp from pter
32,315,344 bp from pter
11,645 bases
Minus strand

Genomic View for ZAR1L Gene

Genes around ZAR1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZAR1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZAR1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAR1L Gene

Proteins for ZAR1L Gene

  • Protein details for ZAR1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ZAR1-like protein
    Protein Accession:
    Secondary Accessions:
    • B2RV03
    • B7ZBU2

    Protein attributes for ZAR1L Gene

    321 amino acids
    Molecular mass:
    36010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZAR1L Gene

Post-translational modifications for ZAR1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZAR1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZAR1L Gene

Domains & Families for ZAR1L Gene

Gene Families for ZAR1L Gene

Protein Domains for ZAR1L Gene


Suggested Antigen Peptide Sequences for ZAR1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZAR1 family.
  • Belongs to the ZAR1 family.
genes like me logo Genes that share domains with ZAR1L: view

Function for ZAR1L Gene

Phenotypes for ZAR1L Gene

GenomeRNAi human phenotypes for ZAR1L:
genes like me logo Genes that share phenotypes with ZAR1L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZAR1L Gene

Localization for ZAR1L Gene

Subcellular locations from

Jensen Localization Image for ZAR1L Gene COMPARTMENTS Subcellular localization image for ZAR1L gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for ZAR1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZAR1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZAR1L Gene

Pathways & Interactions for ZAR1L Gene

SuperPathways for ZAR1L Gene

No Data Available

Interacting Proteins for ZAR1L Gene

Gene Ontology (GO) - Biological Process for ZAR1L Gene


No data available for Pathways by source and SIGNOR curated interactions for ZAR1L Gene

Transcripts for ZAR1L Gene

mRNA/cDNA for ZAR1L Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZAR1L Gene

Zygote arrest 1-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZAR1L Gene

No ASD Table

Relevant External Links for ZAR1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZAR1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZAR1L Gene

mRNA differential expression in normal tissues according to GTEx for ZAR1L Gene

This gene is overexpressed in Testis (x22.8).

Protein differential expression in normal tissues from HIPED for ZAR1L Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZAR1L Gene

Protein tissue co-expression partners for ZAR1L Gene

NURSA nuclear receptor signaling pathways regulating expression of ZAR1L Gene:


SOURCE GeneReport for Unigene cluster for ZAR1L Gene:

genes like me logo Genes that share expression patterns with ZAR1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZAR1L Gene

Orthologs for ZAR1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZAR1L Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZAR1L 34 35
  • 82.45 (n)
(Bos Taurus)
Mammalia ZAR1L 34 35
  • 78.2 (n)
-- 35
  • 68 (a)
(Mus musculus)
Mammalia Zar1l 34 16 35
  • 74.16 (n)
(Monodelphis domestica)
Mammalia ZAR1L 35
  • 57 (a)
(Gallus gallus)
Aves ZAR1L 34
  • 63.69 (n)
ZAR1 35
  • 52 (a)
(Anolis carolinensis)
Reptilia ZAR1L 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC734032 34
  • 61.36 (n)
(Danio rerio)
Actinopterygii zar1l 34 35
  • 56.03 (n)
Species where no ortholog for ZAR1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAR1L Gene

Gene Tree for ZAR1L (if available)
Gene Tree for ZAR1L (if available)

Paralogs for ZAR1L Gene

Paralogs for ZAR1L Gene

genes like me logo Genes that share paralogs with ZAR1L: view

Variants for ZAR1L Gene

Sequence variations from dbSNP and Humsavar for ZAR1L Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs112619627 -- 32,305,235(+) TTTTT(C/T)TCTTT intron-variant
rs114715369 -- 32,310,459(+) CCCAG(A/G)TGGAC intron-variant
rs115018173 -- 32,310,929(+) TGTAC(G/T)TTTCC intron-variant
rs115358685 -- 32,307,106(+) ATACA(C/T)AATAA intron-variant
rs115670513 -- 32,306,616(+) ATATA(C/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZAR1L Gene

Variant ID Type Subtype PubMed ID
esv3580597 CNV loss 25503493

Variation tolerance for ZAR1L Gene

Gene Damage Index Score: 3.33; 53.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZAR1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZAR1L Gene

Disorders for ZAR1L Gene

Relevant External Links for ZAR1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZAR1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZAR1L Gene

Publications for ZAR1L Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. A putative protein structurally related to zygote arrest 1 (Zar1), Zar1-like, is encoded by a novel gene conserved in the vertebrate lineage. (PMID: 18442940) Sangiorgio L. … Simonic T. (Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2008) 2 3 64
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  4. Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells. (PMID: 20202217) Misra S. … Chaudhuri G. (Mol. Cancer 2010) 3 64
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64

Products for ZAR1L Gene

Sources for ZAR1L Gene

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