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Aliases &
Descriptions
for ZAR1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| | | Descriptions |
|---|
| Oocyte-specific maternal effect factor 3 | | zygote arrest 1 2 |
|
| |
Search outside databases for aliases for ZAR1 genePrevious GC identifers: GC04U900018 GC04P048342 GC04P048407 GC04P048333 |
Summaries
for ZAR1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ZAR1:
The female gamete, the oocyte, serves the distinct purpose of transmitting the maternal genome and
other maternal factors critical for postovulation events. Oocytes have diverse functions in
ovarian folliculogenesis, fertilization, and embryogenesis. ZAR1 is an oocyte-specific gene that
appears to function at the oocyte-to-gamete transition (Wu et al., 2003 [PubMed
12539046]).[supplied by OMIM]
UniProtKB/Swiss-Prot: ZAR1_HUMAN, Q86SH2Function: Essential for female fertility. May play a role in the oocyte-to-embryo transition (By
similarity) |
Genomic Location
for ZAR1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the ZAR1 gene 
Entrez Gene cytogenetic band: 4p11 Ensembl cytogenetic band: 4p12 HGNC cytogenetic band: 4p11ZAR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P048187:
(about GC identifiers)
Start:
|
48,187,066 bp from pter |
End:
|
48,191,181 bp from pter |
Size:
|
4,116 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_006238.10
| Proteins
for ZAR1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ZAR1_HUMAN, Q86SH2 (See
protein sequence)Recommended Name: Zygote arrest protein 1 Size: 424 amino acids; 45873 Da
Subcellular location: Cytoplasm (By similarity)REFSEQ proteins: NP_783318.1
ENSEMBL proteins: ENSP00000329803
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
About this table
Antibodies for ZAR1:
Assays for ZAR1: | Protein
Domains/
Families
for ZAR1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86SH2 UniProtKB/Swiss-Prot: ZAR1_HUMAN, Q86SH2Similarity: Belongs to the ZAR1 family | Gene Function
for ZAR1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175619
 Applied Biosystems Silencer® siRNAs for ZAR1
 Sigma-Aldrich siRNA for ZAR1
Sigma-Aldrich shRNA for ZAR1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_175619
Myc/DDK tagged cDNA clone in CMV expression vector: NM_175619
untagged cDNA clone in CMV expression vector: NM_175619
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_175619
UniProtKB/Swiss-Prot: ZAR1_HUMAN, Q86SH2Function: Essential for female fertility. May play a role in the oocyte-to-embryo transition (By
similarity)1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Zar1):
| Pathways & Interactions
for ZAR1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
--1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- |
About this table
|
Drugs & Compounds
for ZAR1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ZAR1
|
Transcripts
for ZAR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175619
Sigma-Aldrich siRNA for ZAR1
Sigma-Aldrich shRNA for ZAR1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_175619 REFSEQ mRNAs for ZAR1 gene: NM_175619.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_175619
OriGene GFP tagged cDNA clone in CMV expression vector: NM_175619
Myc/DDK tagged cDNA clone in CMV expression vector: NM_175619
untagged cDNA clone in CMV expression vector: NM_175619
Additional cDNA sequence: AY191416.1 BC136265.1 1 DOTS entry: DT.91723347 4 AceView cDNA sequences:AY191416 NM_175619 AI217763 BF742595
 highest scoring ESTs for ZAR1:AI217763 AY191416 BF742595 NM_175619 Unigene Cluster for ZAR1: Zygote arrest 1 Hs.276457 [show with all ESTs]Unigene Representative Sequence: NM_175619
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000327939
|
Expression
for ZAR1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ZAR1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ZAR1
1 / 2 2 probe-sets matching ZAR1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAAGGCAGTG
SOURCE GeneReport for Unigene cluster: Hs.276457
UniProtKB/Swiss-Prot: ZAR1_HUMAN, Q86SH2Tissue specificity: Ovary and testis |
Orthologs
for ZAR1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ZAR1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for ZAR1
ENSEMBL Gene Tree for ZAR1 | Paralogs
for ZAR1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for ZAR1 gene
- RP11-37E23.42
|
SNPs/Variants
for ZAR1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ZAR1 (up to first 250kb)
|
Disorders & Mutations
for ZAR1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607520
|
Medical News
for ZAR1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ZAR1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for ZAR1 gene: |
Search for ZAR1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZAR1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ZAR1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZAR1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for ZAR1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for ZAR1:
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