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Aliases for ZAR1 Gene

Aliases for ZAR1 Gene

  • Zygote Arrest 1 2 3
  • Oocyte-Specific Maternal Effect Factor 3 4
  • Zinc Finger, 3CxxC-Type 6 3
  • Zygote Arrest Protein 1 3
  • 3CxxC-Type 6 2
  • Zinc Finger 2
  • Z3CXXC6 3

External Ids for ZAR1 Gene

Previous GeneCards Identifiers for ZAR1 Gene

  • GC04U900018
  • GC04P048342
  • GC04P048407
  • GC04P048333
  • GC04P048187
  • GC04P047812

Summaries for ZAR1 Gene

Entrez Gene Summary for ZAR1 Gene

  • This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. [provided by RefSeq, Jul 2013]

GeneCards Summary for ZAR1 Gene

ZAR1 (Zygote Arrest 1) is a Protein Coding gene. Diseases associated with ZAR1 include western equine encephalitis. An important paralog of this gene is ZAR1L.

UniProtKB/Swiss-Prot for ZAR1 Gene

  • Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAR1 Gene

Genomics for ZAR1 Gene

Regulatory Elements for ZAR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZAR1 Gene

Start:
48,490,252 bp from pter
End:
48,494,389 bp from pter
Size:
4,138 bases
Orientation:
Plus strand

Genomic View for ZAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAR1 Gene

Proteins for ZAR1 Gene

  • Protein details for ZAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SH2-ZAR1_HUMAN
    Recommended name:
    Zygote arrest protein 1
    Protein Accession:
    Q86SH2
    Secondary Accessions:

    Protein attributes for ZAR1 Gene

    Size:
    424 amino acids
    Molecular mass:
    45873 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZAR1 Gene

Proteomics data for ZAR1 Gene at MOPED

Post-translational modifications for ZAR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZAR1 Gene

Domains for ZAR1 Gene

Protein Domains for ZAR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZAR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SH2

UniProtKB/Swiss-Prot:

ZAR1_HUMAN :
  • Q86SH2
Family:
  • Belongs to the ZAR1 family.
genes like me logo Genes that share domains with ZAR1: view

No data available for Gene Families for ZAR1 Gene

Function for ZAR1 Gene

Molecular function for ZAR1 Gene

UniProtKB/Swiss-Prot Function: Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).

Phenotypes for ZAR1 Gene

genes like me logo Genes that share phenotypes with ZAR1: view

Animal Models for ZAR1 Gene

MGI Knock Outs for ZAR1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZAR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for ZAR1 Gene

Localization for ZAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZAR1 Gene COMPARTMENTS Subcellular localization image for ZAR1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZAR1: view

Pathways for ZAR1 Gene

SuperPathways for ZAR1 Gene

No Data Available

Interacting Proteins for ZAR1 Gene

Gene Ontology (GO) - Biological Process for ZAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with ZAR1: view

No data available for Pathways by source for ZAR1 Gene

Transcripts for ZAR1 Gene

mRNA/cDNA for ZAR1 Gene

(4) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZAR1 Gene

Zygote arrest 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZAR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZAR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZAR1 Gene

No ASD Table

Relevant External Links for ZAR1 Gene

GeneLoc Exon Structure for
ZAR1
ECgene alternative splicing isoforms for
ZAR1

Expression for ZAR1 Gene

mRNA expression in normal human tissues for ZAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZAR1 Gene

This gene is overexpressed in Testis (17.2) and Brain - Substantia nigra (7.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZAR1 Gene

SOURCE GeneReport for Unigene cluster for ZAR1 Gene Hs.276457

mRNA Expression by UniProt/SwissProt for ZAR1 Gene

Q86SH2-ZAR1_HUMAN
Tissue specificity: Ovary and testis.
genes like me logo Genes that share expressions with ZAR1: view

In Situ Assay Products

Orthologs for ZAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZAR1 35
  • 99.14 (n)
  • 98.35 (a)
ZAR1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZAR1 35
  • 78.6 (n)
  • 69.47 (a)
ZAR1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZAR1 35
  • 90.06 (n)
  • 99.04 (a)
ZAR1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zar1 35
  • 70.82 (n)
  • 60.39 (a)
Zar1 16
Zar1 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZAR1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZAR1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zar1 35
  • 71.01 (n)
  • 61.22 (a)
chicken
(Gallus gallus)
Aves ZAR1 35
  • 70.7 (n)
  • 74.74 (a)
lizard
(Anolis carolinensis)
Reptilia ZAR1 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25849 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17239 35
zar1 35
  • 59.79 (n)
  • 64.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9117 35
zebrafish
(Danio rerio)
Actinopterygii zar1 35
  • 57.41 (n)
  • 54.63 (a)
zar1 36
  • 48 (a)
OneToOne
Species with no ortholog for ZAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAR1 Gene

ENSEMBL:
Gene Tree for ZAR1 (if available)
TreeFam:
Gene Tree for ZAR1 (if available)

Paralogs for ZAR1 Gene

Paralogs for ZAR1 Gene

Pseudogenes.org Pseudogenes for ZAR1 Gene

genes like me logo Genes that share paralogs with ZAR1: view

Variants for ZAR1 Gene

Sequence variations from dbSNP and Humsavar for ZAR1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs7340880 -- 48,491,371(+) TGGGC(A/C/T)ACTTC intron-variant
rs7694862 -- 48,493,598(+) GCCTC(C/T)TGTCA intron-variant
rs9993088 -- 48,492,529(+) GCCAG(A/C)CTTAT intron-variant
rs9997932 -- 48,490,171(+) GTGGC(A/T)GGAAG upstream-variant-2KB
rs10008444 -- 48,490,417(+) CAGCA(C/G)CGCGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZAR1 Gene

Variant ID Type Subtype PubMed ID
nsv470034 CNV Gain 18288195
nsv829925 CNV Gain+Loss 17160897
dgv5542n71 CNV Loss 21882294

Relevant External Links for ZAR1 Gene

HapMap Linkage Disequilibrium report
ZAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZAR1 Gene

Disorders for ZAR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ZAR1 Gene including...

Search for ZAR1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ZAR1 Gene

genes like me logo Genes that share disorders with ZAR1: view

No data available for UniProtKB/Swiss-Prot for ZAR1 Gene

Publications for ZAR1 Gene

  1. Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries. (PMID: 12773403) Wu X. … Matzuk M.M. (Biol. Reprod. 2003) 3 4 23
  2. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. (PMID: 12539046) Wu X. … Matzuk M.M. (Nat. Genet. 2003) 2 3 4
  3. Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells. (PMID: 16551357) Uzbekova S. … Mermillod P. (Reprod. Biol. Endocrinol. 2006) 3 23
  4. Developmental competence of human in vitro aged oocytes as host cells for nuclear transfer. (PMID: 16957049) Hall V.J. … Stojkovic M. (Hum. Reprod. 2007) 23
  5. Distinct sets of developmentally regulated genes that are expressed by human oocytes and human embryonic stem cells. (PMID: 17126334) Zhang P. … Kere J. (Fertil. Steril. 2007) 23

Products for ZAR1 Gene

Sources for ZAR1 Gene

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