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Aliases for ZAR1 Gene

Aliases for ZAR1 Gene

  • Zygote Arrest 1 2 3 5
  • Oocyte-Specific Maternal Effect Factor 3 4
  • Zinc Finger, 3CxxC-Type 6 2 3
  • Zygote Arrest Protein 1 3
  • Z3CXXC6 3

External Ids for ZAR1 Gene

Previous GeneCards Identifiers for ZAR1 Gene

  • GC04U900018
  • GC04P048342
  • GC04P048407
  • GC04P048333
  • GC04P048187
  • GC04P047812

Summaries for ZAR1 Gene

Entrez Gene Summary for ZAR1 Gene

  • This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. [provided by RefSeq, Jul 2013]

GeneCards Summary for ZAR1 Gene

ZAR1 (Zygote Arrest 1) is a Protein Coding gene. An important paralog of this gene is ZAR1L.

UniProtKB/Swiss-Prot for ZAR1 Gene

  • Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAR1 Gene

Genomics for ZAR1 Gene

Regulatory Elements for ZAR1 Gene

Enhancers for ZAR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ZAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZAR1 Gene

48,490,252 bp from pter
48,498,122 bp from pter
7,871 bases
Plus strand

Genomic View for ZAR1 Gene

Genes around ZAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAR1 Gene

Proteins for ZAR1 Gene

  • Protein details for ZAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zygote arrest protein 1
    Protein Accession:

    Protein attributes for ZAR1 Gene

    424 amino acids
    Molecular mass:
    45873 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZAR1 Gene

Post-translational modifications for ZAR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZAR1 Gene

Domains & Families for ZAR1 Gene

Gene Families for ZAR1 Gene

Protein Domains for ZAR1 Gene


Suggested Antigen Peptide Sequences for ZAR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZAR1 family.
  • Belongs to the ZAR1 family.
genes like me logo Genes that share domains with ZAR1: view

Function for ZAR1 Gene

Molecular function for ZAR1 Gene

UniProtKB/Swiss-Prot Function:
Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).
genes like me logo Genes that share phenotypes with ZAR1: view

Animal Models for ZAR1 Gene

MGI Knock Outs for ZAR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZAR1 Gene

Localization for ZAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAR1 Gene


Subcellular locations from

Jensen Localization Image for ZAR1 Gene COMPARTMENTS Subcellular localization image for ZAR1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZAR1: view

Pathways & Interactions for ZAR1 Gene

SuperPathways for ZAR1 Gene

No Data Available

Interacting Proteins for ZAR1 Gene

Gene Ontology (GO) - Biological Process for ZAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZAR1: view

No data available for Pathways by source and SIGNOR curated interactions for ZAR1 Gene

Drugs & Compounds for ZAR1 Gene

No Compound Related Data Available

Transcripts for ZAR1 Gene

mRNA/cDNA for ZAR1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZAR1 Gene

Zygote arrest 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZAR1 Gene

No ASD Table

Relevant External Links for ZAR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZAR1 Gene

mRNA expression in normal human tissues for ZAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZAR1 Gene

This gene is overexpressed in Testis (x17.2) and Brain - Substantia nigra (x7.5).

Protein differential expression in normal tissues from HIPED for ZAR1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZAR1 Gene

Protein tissue co-expression partners for ZAR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZAR1 Gene:


SOURCE GeneReport for Unigene cluster for ZAR1 Gene:


mRNA Expression by UniProt/SwissProt for ZAR1 Gene:

Tissue specificity: Ovary and testis.
genes like me logo Genes that share expression patterns with ZAR1: view

Primer Products

Orthologs for ZAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZAR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZAR1 34
  • 78.6 (n)
  • 69.47 (a)
ZAR1 35
  • 67 (a)
(Canis familiaris)
Mammalia ZAR1 34
  • 90.06 (n)
  • 99.04 (a)
ZAR1 35
  • 85 (a)
(Mus musculus)
Mammalia Zar1 34
  • 70.82 (n)
  • 60.39 (a)
Zar1 16
Zar1 35
  • 50 (a)
(Pan troglodytes)
Mammalia ZAR1 34
  • 99.14 (n)
  • 98.35 (a)
ZAR1 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Zar1 34
  • 71.01 (n)
  • 61.22 (a)
(Monodelphis domestica)
Mammalia ZAR1 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia ZAR1 35
  • 94 (a)
(Gallus gallus)
Aves ZAR1 34
  • 70.7 (n)
  • 74.74 (a)
(Anolis carolinensis)
Reptilia ZAR1 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17239 34
zar1 34
  • 59.79 (n)
  • 64.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25849 34
(Danio rerio)
Actinopterygii zar1 34
  • 57.41 (n)
  • 54.63 (a)
zar1 35
  • 48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9117 34
Species where no ortholog for ZAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAR1 Gene

Gene Tree for ZAR1 (if available)
Gene Tree for ZAR1 (if available)

Paralogs for ZAR1 Gene

Paralogs for ZAR1 Gene Pseudogenes for ZAR1 Gene

genes like me logo Genes that share paralogs with ZAR1: view

Variants for ZAR1 Gene

Sequence variations from dbSNP and Humsavar for ZAR1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs7340880 -- 48,491,371(+) TGGGC(A/C/T)ACTTC intron-variant
rs7694862 -- 48,493,598(+) GCCTC(C/T)TGTCA intron-variant
rs13114836 -- 48,493,560(+) CTTAG(C/G/T)TAATC intron-variant
rs9993088 -- 48,492,529(+) GCCAG(A/C)CTTAT intron-variant
rs9997932 -- 48,490,171(+) GTGGC(A/T)GGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZAR1 Gene

Variant ID Type Subtype PubMed ID
nsv470034 CNV gain 18288195
nsv594121 CNV gain 21841781
nsv829925 CNV gain+loss 17160897

Variation tolerance for ZAR1 Gene

Gene Damage Index Score: 9.26; 88.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZAR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZAR1 Gene

Disorders for ZAR1 Gene

Relevant External Links for ZAR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZAR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZAR1 Gene

Publications for ZAR1 Gene

  1. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. (PMID: 12539046) Wu X. … Matzuk M.M. (Nat. Genet. 2003) 2 3 4 65
  2. Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries. (PMID: 12773403) Wu X. … Matzuk M.M. (Biol. Reprod. 2003) 3 4 22 65
  3. Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells. (PMID: 16551357) Uzbekova S. … Mermillod P. (Reprod. Biol. Endocrinol. 2006) 3 22 65
  4. Identification of frequent differentially methylated region in sporadic bladder cancers. (PMID: 25227574) Hasegawa R. … Takahashi S. (Urol. Int. 2015) 3 65
  5. Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I. (PMID: 24787227) Brebi P. … Roa J.C. (Biomarkers 2014) 3 65

Products for ZAR1 Gene

Sources for ZAR1 Gene

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