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Aliases for ZAR1 Gene

Aliases for ZAR1 Gene

  • Zygote Arrest 1 2 3 5
  • Oocyte-Specific Maternal Effect Factor 3 4
  • Zinc Finger, 3CxxC-Type 6 2 3
  • Zygote Arrest Protein 1 3
  • Z3CXXC6 3

External Ids for ZAR1 Gene

Previous GeneCards Identifiers for ZAR1 Gene

  • GC04U900018
  • GC04P048342
  • GC04P048407
  • GC04P048333
  • GC04P048187
  • GC04P047812

Summaries for ZAR1 Gene

Entrez Gene Summary for ZAR1 Gene

  • This maternal effect gene is oocyte-specific and encodes a protein that is thought to function in the initiation of embryogenesis. A similar protein in mouse is required for female fertility. [provided by RefSeq, Jul 2013]

GeneCards Summary for ZAR1 Gene

ZAR1 (Zygote Arrest 1) is a Protein Coding gene. Among its related pathways are Preimplantation Embryo. An important paralog of this gene is ZAR1L.

UniProtKB/Swiss-Prot for ZAR1 Gene

  • Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAR1 Gene

Genomics for ZAR1 Gene

Regulatory Elements for ZAR1 Gene

Enhancers for ZAR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G048336 1.4 FANTOM5 ENCODE 10.3 -150.0 -149966 6.9 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 TEC ZAR1 TXK SLAIN2 SLC10A4 GC04M048291
GH04G048316 1.1 Ensembl ENCODE 10.8 -174.1 -174051 0.4 CTCF CBX3 ARNT TEAD4 ARID4B ZMYM3 ZNF2 RAD21 CHAMP1 TEAD3 TEC ZAR1 TXK SLC10A4 GC04M048291 SLAIN2
GH04G048578 0.8 ENCODE 10.5 +88.3 88317 0.1 HDGF CTCF ARNT ARID4B CEBPG RAD21 ZNF143 SMC3 SMARCA5 ZNF654 OCIAD2 ZAR1 OCIAD1-AS1 RNU5E-3P GC04P048658
GH04G048115 0.7 dbSUPER 9.8 -372.5 -372486 3.9 PKNOX1 CEBPG FOSL1 GATA3 CTBP1 ZNF316 FOS FOSL2 NFE2 RCOR1 CNGA1 ZAR1 ENSG00000259959 TXK ENSG00000283499
GH04G048126 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -359.6 -359633 8.5 HDGF FOXA2 PKNOX1 ATF1 ARNT SIN3A BRCA1 TCF12 GATA2 CBX5 TEC TXK RNU6-838P ENSG00000248254 CNGA1 ZAR1 ENSG00000283499
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZAR1 Gene

Chromosome:
4
Start:
48,490,252 bp from pter
End:
48,498,122 bp from pter
Size:
7,871 bases
Orientation:
Plus strand

Genomic View for ZAR1 Gene

Genes around ZAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAR1 Gene

Proteins for ZAR1 Gene

  • Protein details for ZAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SH2-ZAR1_HUMAN
    Recommended name:
    Zygote arrest protein 1
    Protein Accession:
    Q86SH2

    Protein attributes for ZAR1 Gene

    Size:
    424 amino acids
    Molecular mass:
    45873 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZAR1 Gene

Post-translational modifications for ZAR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZAR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZAR1 Gene

Domains & Families for ZAR1 Gene

Gene Families for ZAR1 Gene

Protein Domains for ZAR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZAR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SH2

UniProtKB/Swiss-Prot:

ZAR1_HUMAN :
  • Belongs to the ZAR1 family.
Family:
  • Belongs to the ZAR1 family.
genes like me logo Genes that share domains with ZAR1: view

Function for ZAR1 Gene

Molecular function for ZAR1 Gene

UniProtKB/Swiss-Prot Function:
Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).
genes like me logo Genes that share phenotypes with ZAR1: view

Animal Models for ZAR1 Gene

MGI Knock Outs for ZAR1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZAR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZAR1 Gene

Localization for ZAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZAR1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZAR1: view

Pathways & Interactions for ZAR1 Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with ZAR1: view

Pathways by source for ZAR1 Gene

1 BioSystems pathway for ZAR1 Gene

Interacting Proteins for ZAR1 Gene

Gene Ontology (GO) - Biological Process for ZAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ZAR1: view

No data available for SIGNOR curated interactions for ZAR1 Gene

Drugs & Compounds for ZAR1 Gene

No Compound Related Data Available

Transcripts for ZAR1 Gene

mRNA/cDNA for ZAR1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZAR1 Gene

Zygote arrest 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZAR1

Alternative Splicing Database (ASD) splice patterns (SP) for ZAR1 Gene

No ASD Table

Relevant External Links for ZAR1 Gene

GeneLoc Exon Structure for
ZAR1
ECgene alternative splicing isoforms for
ZAR1

Expression for ZAR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZAR1 Gene

This gene is overexpressed in Testis (x17.2) and Brain - Substantia nigra (x7.5).

Protein differential expression in normal tissues from HIPED for ZAR1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZAR1 Gene



Protein tissue co-expression partners for ZAR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZAR1 Gene:

ZAR1

SOURCE GeneReport for Unigene cluster for ZAR1 Gene:

Hs.276457

mRNA Expression by UniProt/SwissProt for ZAR1 Gene:

Q86SH2-ZAR1_HUMAN
Tissue specificity: Ovary and testis.
genes like me logo Genes that share expression patterns with ZAR1: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZAR1 Gene

Orthologs for ZAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZAR1 34 35
  • 99.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZAR1 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZAR1 34 35
  • 90.06 (n)
cow
(Bos Taurus)
Mammalia ZAR1 34 35
  • 78.6 (n)
rat
(Rattus norvegicus)
Mammalia Zar1 34
  • 71.01 (n)
mouse
(Mus musculus)
Mammalia Zar1 34 16 35
  • 70.82 (n)
oppossum
(Monodelphis domestica)
Mammalia ZAR1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZAR1 34
  • 70.7 (n)
lizard
(Anolis carolinensis)
Reptilia ZAR1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zar1 34
  • 59.79 (n)
Str.17239 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25849 34
zebrafish
(Danio rerio)
Actinopterygii zar1 34 35
  • 57.41 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9117 34
Species where no ortholog for ZAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAR1 Gene

ENSEMBL:
Gene Tree for ZAR1 (if available)
TreeFam:
Gene Tree for ZAR1 (if available)

Paralogs for ZAR1 Gene

Paralogs for ZAR1 Gene

Pseudogenes.org Pseudogenes for ZAR1 Gene

genes like me logo Genes that share paralogs with ZAR1: view

Variants for ZAR1 Gene

Sequence variations from dbSNP and Humsavar for ZAR1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10008444 -- 48,490,417(+) CAGCA(C/G)CGCGG nc-transcript-variant, reference, missense
rs1000930871 -- 48,497,262(+) AATAA(A/G)TGCTA nc-transcript-variant, downstream-variant-500B
rs1000984887 -- 48,496,979(+) ATGTA(-/ATG)ATTTC nc-transcript-variant, downstream-variant-500B
rs1001129638 -- 48,491,385(+) ATTTC(C/T)GAGAC intron-variant
rs1001298472 -- 48,491,116(+) CCGCG(A/G)TCGGC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZAR1 Gene

Variant ID Type Subtype PubMed ID
nsv470034 CNV gain 18288195
nsv594121 CNV gain 21841781
nsv829925 CNV gain+loss 17160897

Variation tolerance for ZAR1 Gene

Gene Damage Index Score: 9.26; 88.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZAR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZAR1 Gene

Disorders for ZAR1 Gene

Relevant External Links for ZAR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZAR1

No disorders were found for ZAR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZAR1 Gene

Publications for ZAR1 Gene

  1. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. (PMID: 12539046) Wu X. … Matzuk M.M. (Nat. Genet. 2003) 2 3 4 64
  2. Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries. (PMID: 12773403) Wu X. … Matzuk M.M. (Biol. Reprod. 2003) 3 4 22 64
  3. Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells. (PMID: 16551357) Uzbekova S. … Mermillod P. (Reprod. Biol. Endocrinol. 2006) 3 22 64
  4. Identification of frequent differentially methylated region in sporadic bladder cancers. (PMID: 25227574) Hasegawa R. … Takahashi S. (Urol. Int. 2015) 3 64
  5. Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I. (PMID: 24787227) Brebi P. … Roa J.C. (Biomarkers 2014) 3 64

Products for ZAR1 Gene

Sources for ZAR1 Gene

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