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ZAP70 Gene

protein-coding GIFtS: 72

GC02P097788

zeta-chain (TCR) associated protein kinase 70kDa
(Previous name: zeta-chain (TCR) associated protein kinase (70 kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SRK)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.2 ^³
FLJ17670 ^²
FLJ17679 ^²
SRK ^², ³, ⁵
STD ^¹, ², ⁵
TZK ^²
ZAP-70 ^¹, ²

Descriptions
70 kDa zeta-associated protein ^³
Syk-related tyrosine kinase ^², ³
zeta-chain (TCR) associated protein kinase (70 kD) ^¹, ²
zeta-chain (TCR) associated protein kinase 70kDa ^²
zeta-chain associated protein kinase 70kDa ^²
zeta-chain associated protein kinase, 70kD ^²

External Ids
HGNC: 12858¹
Entrez Gene: 7535²
UniProtKB: P43403³
Ensembl: ENSG00000115085⁷

Search outside databases for aliases for ZAP70 gene

Previous GC identifers: GC02P096211 GC02P096782 GC02P097934 GC02P097951

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ZAP70:

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in

T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine

residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of

TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This

enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell

defect, a severe combined immunodeficiency disease characterized by a selective absence of

CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ZAP70_HUMAN, P43403

Function: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated

IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not

Gene Wiki entry for ZAP70 (ZAP-70)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZAP70 gene

Entrez Gene cytogenetic band: 2q12 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11-q13

ZAP70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P097788: (about GC identifiers)

Start:	97,696,463 bp from pter
End:	97,722,755 bp from pter
Size:	26,293 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022171.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ZAP70_HUMAN, P43403 (See protein sequence)

Recommended Name: Tyrosine-protein kinase ZAP-70

Size: 619 amino acids; 69872 Da

Subunit: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated

NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated.

The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB.

Interacts with DEF6 (By similarity). Interacts with FCRL3

Subcellular location: Cytoplasm (By similarity). Note=After antigen stimulation, isoform 1

concentrates at the immunological synapse and isoform 2 remains cytoplasmic (By similarity)

PDB structures from and Proteopedia :

1M61 (3D)

1U59 (3D)

2OQ1 (3D)

2OZO (3D)

Secondary accessions: A6NFP4 Q6PIA4 Q8IXD6 Q9UBS6

Alternative splicing: 3 isoforms: P43403-1 P43403-2 P43403-3

Post-translational modifications:

Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319

phosphorylation is essential for full activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001070.2 NP_997402.1

ENSEMBL proteins:

ENSP00000264972 ENSP00000374169

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ZAP70
	Millipore Purified and/or Recombinant ZAP70 Protein
	Sigma-Aldrich Proteins for ZAP70
	R&D Systems Recombinant & Natural Proteins for ZAP70
	Enzo Life Sciences proteins for ZAP70
	Recombinant Proteins from Abcam (ZAP70)
	Human Recombinant Proteins from Abnova (ZAP70)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	TAS	12359715
GO:0005829	cytosol	EXP	11048639 17652306
GO:0042101	T cell receptor complex	IDA	8176201

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Antibodies for ZAP70:

	Invitrogen Antibodies for ZAP70
	Millipore Mono- and Polyclonal Antibodies for the study of ZAP70
	Sigma-Aldrich Antibody Arrays and Antibodies for ZAP70
	R&D Systems Antibodies for ZAP70
	Cell Signaling Technology (CST) Antibodies for ZAP70 (Zap-70)
	Antibodies from Abcam (ZAP70), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZAP70)
	Novus Biologicals Antibodies for ZAP70

Assays for ZAP70:

	Invitrogen Assays for ZAP70
	Millipore Kits and Assays for the Analysis of ZAP70
	Browse R&D Systems for biochemical assays
	Cell Signaling Technology (CST) Sandwich ELISA Kits for ZAP70 (Zap-70)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P43403

ProtoNet protein and cluster: P43403

2 Blocks protein families:

IPB000980 SH2 domain signature

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ZAP70_HUMAN, P43403

Domain: The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70

subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 2 SH2 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZAP70)
		Millipore RNAi Products for the Analysis of ZAP70 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ZAP70)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207519

Applied Biosystems Silencer® siRNAs for ZAP70

Sigma-Aldrich siRNA and siRNA Panels for ZAP70

Sigma-Aldrich shRNA Panels and shRNA for ZAP70

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZAP70
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079
untagged cDNA clones in CMV expression vector (see all 3): NM_001079

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001079

UniProtKB/Swiss-Prot: ZAP70_HUMAN, P43403

Function: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated

IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Genatlas biochemistry entry for ZAP70:

CD3 zeta associated tyrosine kinase,SYK (non SRC) family,expressed in T and NK cells,involved in

signal transduction

6 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Zap70):

hematopoietic system	immune system	normal	respiratory system	skeleton
skin/coat/nails

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	7528772 11891219 12359715 12646565
GO:0005524	ATP binding	NAS	1423621
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for ZAP70 (Your Favorite Gene powered by Ingenuity) (see all 9 )

iCOS-iCOSL Signaling in T Helper Cells
Calcium-induced T Lymphocyte Apoptosis
Natural Killer Cell Signaling
CD28 Signaling in T Helper Cells
Primary Immunodeficiency Signaling

GeneDecks ZAP70 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ZAP70

5/122 Interacting proteins for ZAP70 (ENSP00000264972³ P43403^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 122 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN22	Q9Y2R2¹	STRING (score=.958) EBI-1211276, EBI-1211241
SHC1	P29353²	STRING (score=.999) MINT-60980
LCK	P06239¹^,²	STRING (score=.999) EBI-1211276, EBI-1348 MINT-59476 EBI-1211276, EBI-1348 MINT-59476
LCK	P06239¹^,²	STRING (score=.999) EBI-1211276, EBI-1348 MINT-59476 EBI-1211276, EBI-1348 MINT-59476
EGFR	P00533²	MINT-74807

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	NAS	1423621
GO:0006955	immune response	IDA	1423621
GO:0007165	signal transduction	IEA	--
GO:0007243	protein kinase cascade	NAS	1423621
GO:0045059	positive thymic T cell selection	IDA	7630421

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZAP70
10/22 Novoseek chemical compound relationships for ZAP70 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	84.90	480	11744042 (8), 8530437 (5), 7760813 (5), 7642520 (5) (see all 99)
phosphotyrosine	64.67	8	8196616 (1), 12356870 (1), 7822334 (1), 8520027 (1) (see all 7)
piceatannol	51.75	3	17250586 (1), 9723676 (1)
calcium	32.72	19	10748099 (1), 19018007 (1), 8096851 (1), 11588032 (1) (see all 18)
phosphatidylinositol	31.33	7	15100278 (2), 8096851 (1), 9195899 (1), 11418612 (1) (see all 6)
phenylalanine	22.07	6	10779765 (1), 10318843 (1), 11046020 (1), 15100278 (1) (see all 6)
purine	14.91	2	19373658 (1), 17051411 (1)
threonine	9.40	4	16369048 (1), 10725390 (1)
sodium	2.95	1	11566569 (1)
oxygen	0.82	1	11744042 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZAP70)
		Millipore RNAi Products for the Analysis of ZAP70 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ZAP70)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207519

Sigma-Aldrich siRNA and siRNA Panels for ZAP70

Sigma-Aldrich shRNA Panels and shRNA for ZAP70

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001079 NM_207519

REFSEQ mRNAs for ZAP70 gene (2 alternative transcripts):

NM_001079.3 NM_207519.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001079 NM_207519

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001079

Additional cDNA sequence:

AB083211.1 AK303341.1 AK310637.1 BC039039.1 BC053878.1 L05148.1

8 DOTS entries:

DT.302578 DT.100019754 DT.100019752 DT.95142057 DT.100019753 DT.100750057 DT.100727964 DT.97782684

24/54 AceView cDNA sequences (see all 54 ):

NM_207519 BC039039 BQ054223 BE254072 L05148 AI473901 AJ346204 BX092836

BM916976 AB083211 BQ051966 AI382267 AL832287 AA353108 NM_001079 BC053878

BM917637 T28969 AW448979 BQ436251 AI817942 BX436681 BQ053003 BI826450

highest scoring ESTs for ZAP70:

L05148 AA353108 AB083211 AI382267 AI473901 AI817942 AJ346204 AJ573211 AJ713075 AL832287

Unigene Cluster for ZAP70:

Zeta-chain (TCR) associated protein kinase 70kDa

Hs.234569 [show with all ESTs]

Unigene Representative Sequence: BC053878

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZAP70 (see all 9 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	·	16c	^	17a	·
SP1:			-								-		-				-												-						-														-
SP2:																	-												-						-														-
SP3:																																																	-
SP4:																	-												-		-
SP5:																																			-														-

ExUns:	17b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ZAP70

2 Ensembl transcripts including schematic representations:

ENST00000264972 ENST00000389518

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZAP70 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZAP70

¹ / ² / ³

4 probe-sets matching ZAP70 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1498_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L05148	1.00	1.00	1.00	1
214032_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI817942	0.80	1.00	0.91	1
1555613_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214032_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZAP70 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGAGCCTGTT

SOURCE GeneReport for Unigene cluster: Hs.234569
Expression variation in blood from EXPOLDB for ZAP70
UniProtKB/Swiss-Prot: ZAP70_HUMAN, P43403
Tissue specificity: Expressed in T- and natural killer cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZAP70 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ZAP70¹	--	zeta-chain (TCR) associated protein kinase 70kDa	99.57(n) 99.84(a)	459427 XM_515637.2 XP_515637.2
cow (Bos taurus)	ZAP70¹	--	zeta-chain (TCR) associated protein kinase 70kDa	90.1(n) 94.16(a)	504509 XM_865562.2 XP_870655.1
rat (Rattus norvegicus)	Zap70¹	--	zeta-chain (TCR) associated protein kinase	88.15(n) 93.8(a)	301348 NM_001012002.1 NP_001012002.1
mouse (Mus musculus)	Zap70^{1, 5}	1 (20.50 cM)⁵	zeta-chain (TCR) associated protein kinase^{1, 5}	87.88(n)¹ 94.16(a)¹	22637¹ NM_009539.2¹ NP_033565.2¹ AB083210⁵ AB084383⁵ (see all 11)
chicken (Gallus gallus)	ZAP70¹	--	zeta-chain (TCR) associated protein kinase 70kDa	72.45(n) 75.85(a)	420086 XM_418206.2 XP_418206.2

About this table Species with no ortholog for ZAP70

ENSEMBL Gene Tree for ZAP70

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZAP70 gene

SYK² TNK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/193 NCBI SNPs in ZAP70 are shown (see all 193 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 55)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2276645^1,2	C,F,H,O	97696484(-)	`AGCAGG/TCTTGT`	1	--	ut5¹		12	EA NA EU WA	2478
	rs11678558^1,2	A,C,F,H	97722422(+)	`TCCACG/ACCGGC`	2	--	ut3¹ ese³		4	EU EA WA	408
	rs13034349^1,2	C,F,H	97695629(+)	`GAGTGC/TATGAG`	1	--	ng5¹		4	EU EA WA	408
	rs895437^1,2	C,F,H	97716778(+)	`GGTCAC/TTGTGT`	2	--	int¹ ng5¹		7	NA EU EA WA	560
	rs2278699^1,2	C,F,H	97722682(-)	`CAGGGC/GCCAGG`	2	--	ut3¹ ese³		9	EA EU WA	2324
	rs3192177^1,2	C,F,H,O	97720943(+)	`ATGGAG/ATGCCC`	2	E/E	syn¹		9	MN NA EU EA WA	810
	rs11889573^1,2	C,H	97720774(+)	`TCCTAC/TGGCCA`	2	Y/Y	syn¹ ese³		4	EU EA WA	406
	rs6712517^1,2	A,C,F,H	97706796(+)	`TGGCGC/AGCTCA`	1	--	int¹		7	EU EA WA NA	558
	rs6543062^1,2	A,C,F,H	97713571(+)	`gctCCC/TTAATA`	1	--	int¹		4	EU EA WA	418
	rs6714710^1,2	A,C,F,H	97711518(+)	`AGATTT/GAATTG`	1	--	int¹		12	EU EA WA NA	1046

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HapMap Linkage Disequilibrium images for ZAP70 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176947

UniProtKB/Swiss-Prot: ZAP70_HUMAN, P43403

Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an

autosomal recessive form of severe combined immunodeficiency characterized by a selective absence

of CD8-type T-cells

10/42 Novoseek disease relationships for ZAP70 gene (see all 42 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia lymphocytic chronic	90.83	82	15972449 (2), 16418492 (2), 16321853 (2), 17948236 (2) (see all 62)
lymphocytic leukemia chronic b-cell	87.67	40	18223290 (4), 15759031 (2), 17476690 (2), 16906587 (2) (see all 28)
leukaemia lymphocytic	76.05	31	16932341 (2), 17456058 (2), 19144411 (2), 17625948 (2) (see all 21)
severe combined immunodeficiency	57.75	10	8202712 (2), 9801260 (1), 12149205 (1), 8920891 (1) (see all 9)
lymphoma small lymphocytic	52.03	5	15133473 (1), 16280661 (1), 16426914 (1), 18348159 (1) (see all 5)
lymphocytosis	49.21	1	18689273 (1)
leukemia b-cell	48.49	3	14523469 (1), 12393534 (1), 17051411 (1)
trisomy	47.92	5	16434371 (1), 18223290 (1), 18689273 (1), 17143256 (1) (see all 5)
leukemia t-cell	43.13	7	17178387 (2), 7524094 (1), 16369048 (1), 18687687 (1)
leukemia prolymphocytic	40.14	2	15133473 (1), 16642047 (1)

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Genatlas disease: ZAP70

immunodeficiency,severe,combined with selective absence of peripheral CD8+ cells,and presence of

CD4+ T cells,not responding to TCR mediated stimuli in vitro

Human Gene Mutation Database: ZAP70
Tumor Gene Database: ZAP70

(Possibly Related Articles in Doctor's Guide)
About This Section

NHL 2004: Rituximab Adds to Efficacy of Fludarabine/Cyclophosphamide in Chronic Lymphocytic Leukaemia

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/573 PubMed articles for ZAP70 gene (see all 573 ):

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. (PubMed id 1423621)^{1, 2, 3, 4} Chan A.C....Weiss A. (1992)
Identification of a novel isoform of ZAP-70, truncated ZAP kinase. (PubMed id 14985102)^{1, 3, 4} Kuroyama H.... Hirokawa K. (2004)
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. (PubMed id 7528772)^{1, 3, 4} Isakov N....Samelson L.E. (1995)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)^{3, 4} Tao W.A.... Aebersold R. (2005)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{3, 4} Brill L.M....Peters E.C. (2004)
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)^{3, 4} Salomon A.R.... Peters E.C. (2003)
Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem. (PubMed id 12450381)^{3, 4} Folmer R.H.... Xue Y. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7535	HGNC: 12858	AceView: ZAP70	Ensembl:ENSG00000115085	euGenes: HUgn7535
ECgene: ZAP70	H-InvDB: ZAP70

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ZAP70	Genetics and Cytogenetics in Oncology and Haematology
ZAP70base	http://bioinf.uta.fi/ZAP70base/
GeneReviews	http://www.genetests.org/query?gene=ZAP70

Licensable Technologies for ZAP70
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZAP70:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZAP70-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZAP70		Antibodies for ZAP70
	Explore super-pooled esiRNAs		Proteins for ZAP70
	Lentivirus-delivered shRNAs for ZAP70		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ZAP70)
	Antibodies (ZAP70)
	Chimera RNAi (ZAP70)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ZAP70 (Zap-70)

	Recombinant Proteins (ZAP70)
	Antibodies (ZAP70)

Search OriGene for ZAP70

Search Tocris compounds for ZAP70

	Proteins for ZAP70
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ZAP70

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ZAP70 Gene at Home site.
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ZAP70 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for ZAP70

Summaries
for ZAP70

Genomic Location
for ZAP70

Proteins
for ZAP70

Protein Domains/
Families
for ZAP70

Gene Function
for ZAP70

Pathways & Interactions
for ZAP70

Drugs & Compounds
for ZAP70

Transcripts
for ZAP70

Expression
for ZAP70

Orthologs
for ZAP70

Paralogs
for ZAP70

SNPs/Variants
for ZAP70

Disorders & Mutations
for ZAP70

Medical News
for ZAP70

Publications
for ZAP70

Search for ZAP70

Genome Databases showing ZAP70

Other Databases showing ZAP70

Specialized Databases showing ZAP70

Licensable Technologies
for ZAP70

Services
for ZAP70

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZAP70 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor ZAP70

Summariesfor ZAP70

Genomic Locationfor ZAP70

Proteinsfor ZAP70

Protein Domains/Familiesfor ZAP70

Gene Functionfor ZAP70

Pathways & Interactionsfor ZAP70

Drugs & Compoundsfor ZAP70

Transcriptsfor ZAP70

Expression for ZAP70

Orthologsfor ZAP70

Paralogsfor ZAP70

SNPs/Variantsfor ZAP70

Disorders & Mutationsfor ZAP70

Medical Newsfor ZAP70

Publicationsfor ZAP70

Search for ZAP70

Genome Databases showing ZAP70

Other Databases showing ZAP70

Specialized Databases showing ZAP70

Licensable Technologiesfor ZAP70

Servicesfor ZAP70

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZAP70

Summaries
for ZAP70

Genomic Location
for ZAP70

Proteins
for ZAP70

Protein Domains/
Families
for ZAP70

Gene Function
for ZAP70

Pathways & Interactions
for ZAP70

Drugs & Compounds
for ZAP70

Transcripts
for ZAP70

Expression
for ZAP70

Orthologs
for ZAP70

Paralogs
for ZAP70

SNPs/Variants
for ZAP70

Disorders & Mutations
for ZAP70

Medical News
for ZAP70

Publications
for ZAP70

Licensable Technologies
for ZAP70

Services
for ZAP70