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Aliases for ZAN Gene

Aliases for ZAN Gene

  • Zonadhesin (Gene/Pseudogene) 2 3 5
  • Zonadhesin 2 3

External Ids for ZAN Gene

Previous GeneCards Identifiers for ZAN Gene

  • GC07P098866
  • GC07P099928
  • GC07P099943
  • GC07P099944
  • GC07P099975
  • GC07P100169
  • GC07P100333
  • GC07P099690

Summaries for ZAN Gene

Entrez Gene Summary for ZAN Gene

  • This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for ZAN Gene

ZAN (Zonadhesin (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. An important paralog of this gene is FCGBP.

UniProtKB/Swiss-Prot for ZAN Gene

  • Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAN Gene

Genomics for ZAN Gene

Regulatory Elements for ZAN Gene

Enhancers for ZAN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100690 1.3 Ensembl ENCODE 32.5 -39.9 -39907 5.7 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 ZNF143 ZAN GIGYF1 MOSPD3 MBLAC1 MUC3A GAL3ST4 GC07M100687 PIR58923
GH07F100672 1.2 ENCODE 29.9 -56.6 -56591 8.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 PCOLCE GIGYF1 PPP1R35 STAG3L5P ZAN EPHB4 AP4M1 MOSPD3 MIR6875 GNB2
GH07F100687 0.5 ENCODE 26.8 -45.3 -45279 0.9 ZFHX2 FOS NFE2 EGR2 ZAN GIGYF1 MUC3A GC07M100687 PIR58923
GH07F100725 1.2 Ensembl ENCODE 0.4 -7.1 -7081 2.7 CBX3 PKNOX1 ARID4B SIN3A RAD21 RARA ZNF366 SCRT2 ZNF143 FOS MOSPD3 LOC102724094 EPO ZAN
GH07F100745 1.2 FANTOM5 Ensembl ENCODE 0.4 +11.8 11760 0.7 ATF1 ZBTB2 NRF1 BHLHE40 CEBPB POLR2A IKZF1 ZBTB33 TRIM24 CREM SAP25 MUC3A ZAN GC07M100765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZAN on UCSC Golden Path with GeneCards custom track

Genomic Location for ZAN Gene

Chromosome:
7
Start:
100,733,583 bp from pter
End:
100,797,797 bp from pter
Size:
64,215 bases
Orientation:
Plus strand

Genomic View for ZAN Gene

Genes around ZAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAN Gene

Proteins for ZAN Gene

  • Protein details for ZAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y493-ZAN_HUMAN
    Recommended name:
    Zonadhesin
    Protein Accession:
    Q9Y493
    Secondary Accessions:
    • A0FKC8
    • D6W5W4
    • O00218
    • Q96L85
    • Q96L86
    • Q96L87
    • Q96L88
    • Q96L89
    • Q96L90
    • Q9BXN9
    • Q9BZ83
    • Q9BZ84
    • Q9BZ85
    • Q9BZ86
    • Q9BZ87
    • Q9BZ88

    Protein attributes for ZAN Gene

    Size:
    2812 amino acids
    Molecular mass:
    305663 Da
    Quaternary structure:
    • Probably forms covalent oligomers.
    SequenceCaution:
    • Sequence=AAC78790.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76487.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76489.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76491.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76492.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZAN Gene

neXtProt entry for ZAN Gene

Post-translational modifications for ZAN Gene

  • Glycosylation at Asn 333, Asn 493, Asn 1112, Asn 1188, Asn 1685, Asn 1804, Asn 1900, Asn 1946, Asn 2203, Asn 2542, and Asn 2701
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZAN Gene

Domains & Families for ZAN Gene

Suggested Antigen Peptide Sequences for ZAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y493

UniProtKB/Swiss-Prot:

ZAN_HUMAN :
  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
Domain:
  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
  • During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
  • The VWFD domain 2 may mediate covalent oligomerization.
  • Contains 1 EGF-like domain.
  • Contains 3 MAM domains.
  • Contains 4 TIL (trypsin inhibitory-like) domains.
  • Contains 5 VWFC domains.
  • Contains 4 VWFD domains.
genes like me logo Genes that share domains with ZAN: view

No data available for Gene Families for ZAN Gene

Function for ZAN Gene

Molecular function for ZAN Gene

GENATLAS Biochemistry:
zonadhesin,sperm membrane protein,binding the zona pellucida
UniProtKB/Swiss-Prot Function:
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
genes like me logo Genes that share phenotypes with ZAN: view

Animal Models for ZAN Gene

MGI Knock Outs for ZAN:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZAN Gene

Localization for ZAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAN Gene

Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 9126492
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZAN: view

No data available for Subcellular locations from COMPARTMENTS for ZAN Gene

Pathways & Interactions for ZAN Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with ZAN: view

Pathways by source for ZAN Gene

1 Qiagen pathway for ZAN Gene

Interacting Proteins for ZAN Gene

Gene Ontology (GO) - Biological Process for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida NAS 9126492
GO:0016337 single organismal cell-cell adhesion NAS 9126492
genes like me logo Genes that share ontologies with ZAN: view

No data available for SIGNOR curated interactions for ZAN Gene

Transcripts for ZAN Gene

mRNA/cDNA for ZAN Gene

Unigene Clusters for ZAN Gene

Zonadhesin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZAN Gene

No ASD Table

Relevant External Links for ZAN Gene

GeneLoc Exon Structure for
ZAN
ECgene alternative splicing isoforms for
ZAN

Expression for ZAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZAN Gene

mRNA differential expression in normal tissues according to GTEx for ZAN Gene

This gene is overexpressed in Testis (x43.6).

Protein differential expression in normal tissues from HIPED for ZAN Gene

This gene is overexpressed in Pancreas (54.6) and Lung (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZAN Gene



Protein tissue co-expression partners for ZAN Gene

NURSA nuclear receptor signaling pathways regulating expression of ZAN Gene:

ZAN

SOURCE GeneReport for Unigene cluster for ZAN Gene:

Hs.307004

mRNA Expression by UniProt/SwissProt for ZAN Gene:

Q9Y493-ZAN_HUMAN
Tissue specificity: In testis, primarily in haploid spermatids.
genes like me logo Genes that share expression patterns with ZAN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZAN Gene

Orthologs for ZAN Gene

This gene was present in the common ancestor of animals.

Orthologs for ZAN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZAN 34
  • 97.45 (n)
cow
(Bos Taurus)
Mammalia ZAN 34 35
  • 75.03 (n)
mouse
(Mus musculus)
Mammalia Zan 34 16 35
  • 70.13 (n)
rat
(Rattus norvegicus)
Mammalia Zan 34
  • 67.95 (n)
dog
(Canis familiaris)
Mammalia ZAN 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZAN 35
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZAN 35
  • 22 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZAN 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZAN 35
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZAN 35
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cv-2 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
ManyToMany
Species where no ortholog for ZAN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAN Gene

ENSEMBL:
Gene Tree for ZAN (if available)
TreeFam:
Gene Tree for ZAN (if available)

Paralogs for ZAN Gene

Paralogs for ZAN Gene

(1) SIMAP similar genes for ZAN Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZAN: view

Variants for ZAN Gene

Sequence variations from dbSNP and Humsavar for ZAN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10081274 -- 100,741,187(+) ggggc(A/G)gctgg intron-variant
rs10224168 -- 100,766,751(+) TTCCC(C/T)AGACA intron-variant
rs10226460 -- 100,777,011(+) acagg(C/T)gtgag intron-variant
rs10226464 -- 100,777,021(+) gccac(C/T)gcgcc intron-variant
rs10232130 -- 100,768,580(+) CCCTT(C/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZAN Gene

Variant ID Type Subtype PubMed ID
esv3542157 CNV deletion 23714750
esv33833 CNV loss 17666407
esv33610 CNV gain+loss 17666407
esv2761350 CNV loss 21179565
esv2759547 CNV gain+loss 17122850
esv2734893 CNV deletion 23290073
esv2734892 CNV deletion 23290073
esv2734888 CNV deletion 23290073
esv2674171 CNV deletion 23128226
esv2669885 CNV deletion 23128226
esv2648192 CNV deletion 19546169
esv2337044 CNV deletion 18987734
esv22712 CNV loss 19812545
esv2145665 CNV deletion 18987734
dgv3625n106 CNV deletion 24896259
dgv1940e212 CNV loss 25503493
dgv1227e199 CNV deletion 23128226
dgv11533n54 CNV loss 21841781
dgv11532n54 CNV loss 21841781
dgv11531n54 CNV loss 21841781
dgv11530n54 CNV loss 21841781
dgv11529n54 CNV loss 21841781
dgv11528n54 CNV loss 21841781
dgv1126n67 CNV loss 20364138
nsv951388 CNV deletion 24416366
nsv831072 CNV loss 17160897
nsv8184 CNV loss 18304495
nsv607965 CNV loss 21841781
nsv607945 CNV loss 21841781
nsv607944 CNV loss 21841781
nsv607942 CNV gain+loss 21841781
nsv607933 CNV gain 21841781
nsv5869 CNV deletion 18451855
nsv514435 CNV loss 21397061
nsv499699 CNV loss 21111241
nsv470381 CNV loss 18288195
nsv442074 CNV loss 18776908
nsv436558 CNV deletion 17901297
nsv1161590 OTHER complex 26073780
nsv1149912 CNV deletion 26484159
nsv1144196 CNV deletion 24896259
nsv1132079 CNV deletion 24896259
nsv1128350 CNV deletion 24896259
nsv1075983 CNV deletion 25765185
nsv1020837 CNV loss 25217958
esv3614306 CNV loss 21293372
esv3614305 CNV loss 21293372
esv3614304 CNV loss 21293372
esv3572024 CNV loss 25503493
esv3572021 CNV loss 25503493
esv3542158 CNV deletion 23714750

Relevant External Links for ZAN Gene

Human Gene Mutation Database (HGMD)
ZAN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZAN Gene

Disorders for ZAN Gene

Relevant External Links for ZAN

Genetic Association Database (GAD)
ZAN
Human Genome Epidemiology (HuGE) Navigator
ZAN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZAN

No disorders were found for ZAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZAN Gene

Publications for ZAN Gene

  1. Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution. (PMID: 17033959) Gasper J. … Swanson W.J. (Am. J. Hum. Genet. 2006) 2 3 4 22 64
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4 22 64
  3. Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN). (PMID: 9126492) Gao Z. … Garbers D.L. (Genomics 1997) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Zonadhesin D3-polypeptides vary among species but are similar in Equus species capable of interbreeding. (PMID: 19794156) Tardif S. … Hardy D.M. (Biol. Reprod. 2010) 3 22 64

Products for ZAN Gene

Sources for ZAN Gene

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