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Aliases for ZAN Gene

Aliases for ZAN Gene

  • Zonadhesin (Gene/Pseudogene) 2 3 5
  • Zonadhesin 2 3

External Ids for ZAN Gene

Previous GeneCards Identifiers for ZAN Gene

  • GC07P098866
  • GC07P099928
  • GC07P099943
  • GC07P099944
  • GC07P099975
  • GC07P100169
  • GC07P100333
  • GC07P099690

Summaries for ZAN Gene

Entrez Gene Summary for ZAN Gene

  • This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for ZAN Gene

ZAN (Zonadhesin (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. An important paralog of this gene is FCGBP.

UniProtKB/Swiss-Prot for ZAN Gene

  • Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAN Gene

Genomics for ZAN Gene

Regulatory Elements for ZAN Gene

Enhancers for ZAN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G100690 1.6 Ensembl ENCODE dbSUPER 32.5 -39.9 -39907 5.7 HDGF PKNOX1 WRNIP1 ARID4B SIN3A YY1 ZNF143 ZNF263 SP5 REST ZAN GIGYF1 MOSPD3 MBLAC1 MUC3A GAL3ST4 GC07M100687 PIR58923
GH07G100681 0.8 dbSUPER 29.2 -51.1 -51054 2.0 ZSCAN4 SIN3A GLIS2 EGR1 FOS EGR2 ZNF263 ZNF362 SMAD5 ZNF398 ZAN GIGYF1 MBLAC1 GC07M100687 PIR58923 GC07P100676
GH07G100687 0.8 ENCODE dbSUPER 26.8 -45.3 -45279 0.9 ZFHX2 EGR1 FOS NFE2 RBFOX2 EGR2 ZAN GIGYF1 MUC3A GC07M100687 PIR58923
GH07G100745 1.3 FANTOM5 Ensembl ENCODE 0.4 +11.8 11760 0.7 PKNOX1 ATF1 CEBPG POLR2A TRIM24 CREM ZBTB2 L3MBTL2 BHLHE40 NRF1 SAP25 MUC3A ZAN GC07M100765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZAN on UCSC Golden Path with GeneCards custom track

Genomic Location for ZAN Gene

100,733,583 bp from pter
100,797,797 bp from pter
64,215 bases
Plus strand

Genomic View for ZAN Gene

Genes around ZAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAN Gene

Proteins for ZAN Gene

  • Protein details for ZAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0FKC8
    • D6W5W4
    • O00218
    • Q96L85
    • Q96L86
    • Q96L87
    • Q96L88
    • Q96L89
    • Q96L90
    • Q9BXN9
    • Q9BZ83
    • Q9BZ84
    • Q9BZ85
    • Q9BZ86
    • Q9BZ87
    • Q9BZ88

    Protein attributes for ZAN Gene

    2812 amino acids
    Molecular mass:
    305663 Da
    Quaternary structure:
    • Probably forms covalent oligomers.
    • Sequence=AAC78790.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76487.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76489.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76491.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76492.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZAN Gene

neXtProt entry for ZAN Gene

Post-translational modifications for ZAN Gene

  • Glycosylation at isoforms=2, 3, 4, 5, 6, 7333, posLast=493493, isoforms=2, 3, 4, 5, 6, 71112, posLast=11881188, posLast=16851685, isoforms=2, 3, 4, 5, 6, 71804, isoforms=2, 3, 4, 5, 6, 71900, isoforms=2, 3, 4, 5, 6, 71946, posLast=22032203, posLast=25422542, and isoforms=72701
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZAN Gene

Domains & Families for ZAN Gene

Suggested Antigen Peptide Sequences for ZAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
  • During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
  • The VWFD domain 2 may mediate covalent oligomerization.
genes like me logo Genes that share domains with ZAN: view

No data available for Gene Families for ZAN Gene

Function for ZAN Gene

Molecular function for ZAN Gene

GENATLAS Biochemistry:
zonadhesin,sperm membrane protein,binding the zona pellucida
UniProtKB/Swiss-Prot Function:
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
genes like me logo Genes that share phenotypes with ZAN: view

Animal Models for ZAN Gene

MGI Knock Outs for ZAN:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZAN Gene

Localization for ZAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAN Gene

Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 9126492
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZAN: view

No data available for Subcellular locations from COMPARTMENTS for ZAN Gene

Pathways & Interactions for ZAN Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with ZAN: view

Pathways by source for ZAN Gene

1 Qiagen pathway for ZAN Gene

Interacting Proteins for ZAN Gene

Gene Ontology (GO) - Biological Process for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida NAS 9126492
GO:0016337 single organismal cell-cell adhesion NAS 9126492
genes like me logo Genes that share ontologies with ZAN: view

No data available for SIGNOR curated interactions for ZAN Gene

Drugs & Compounds for ZAN Gene

No Compound Related Data Available

Transcripts for ZAN Gene

mRNA/cDNA for ZAN Gene

Unigene Clusters for ZAN Gene

Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZAN Gene

No ASD Table

Relevant External Links for ZAN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZAN Gene

mRNA differential expression in normal tissues according to GTEx for ZAN Gene

This gene is overexpressed in Testis (x43.6).

Protein differential expression in normal tissues from HIPED for ZAN Gene

This gene is overexpressed in Pancreas (54.6) and Lung (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZAN Gene

Protein tissue co-expression partners for ZAN Gene

NURSA nuclear receptor signaling pathways regulating expression of ZAN Gene:


SOURCE GeneReport for Unigene cluster for ZAN Gene:


mRNA Expression by UniProt/SwissProt for ZAN Gene:

Tissue specificity: In testis, primarily in haploid spermatids.
genes like me logo Genes that share expression patterns with ZAN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZAN Gene

Orthologs for ZAN Gene

This gene was present in the common ancestor of animals.

Orthologs for ZAN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZAN 34
  • 97.45 (n)
(Bos Taurus)
Mammalia ZAN 34 35
  • 75.03 (n)
(Mus musculus)
Mammalia Zan 34 16 35
  • 70.13 (n)
(Rattus norvegicus)
Mammalia Zan 34
  • 67.95 (n)
(Canis familiaris)
Mammalia ZAN 35
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ZAN 35
  • 48 (a)
(Monodelphis domestica)
Mammalia ZAN 35
  • 22 (a)
(Gallus gallus)
Aves ZAN 35
  • 35 (a)
(Anolis carolinensis)
Reptilia ZAN 35
  • 32 (a)
(Danio rerio)
Actinopterygii ZAN 35
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta cv-2 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
Species where no ortholog for ZAN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAN Gene

Gene Tree for ZAN (if available)
Gene Tree for ZAN (if available)

Paralogs for ZAN Gene

Paralogs for ZAN Gene

(1) SIMAP similar genes for ZAN Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZAN: view

Variants for ZAN Gene

Sequence variations from dbSNP and Humsavar for ZAN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000075236 -- 100,761,243(+) TTCCC(A/G)CCTGT intron-variant
rs1000133061 -- 100,766,610(+) GAGGT(A/G)TAGGG nc-transcript-variant, reference, missense
rs1000135416 -- 100,760,081(+) TGGTG(A/G)CACTT intron-variant
rs1000172666 -- 100,734,486(+) TGGTG(G/T)TGTGC intron-variant
rs1000265179 -- 100,744,144(+) TGTTG(C/G)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZAN Gene

Variant ID Type Subtype PubMed ID
dgv1126n67 CNV loss 20364138
dgv11528n54 CNV loss 21841781
dgv11529n54 CNV loss 21841781
dgv11530n54 CNV loss 21841781
dgv11531n54 CNV loss 21841781
dgv11532n54 CNV loss 21841781
dgv11533n54 CNV loss 21841781
dgv1227e199 CNV deletion 23128226
dgv1940e212 CNV loss 25503493
dgv3625n106 CNV deletion 24896259
esv2145665 CNV deletion 18987734
esv22712 CNV loss 19812545
esv2337044 CNV deletion 18987734
esv2648192 CNV deletion 19546169
esv2669885 CNV deletion 23128226
esv2674171 CNV deletion 23128226
esv2734888 CNV deletion 23290073
esv2734892 CNV deletion 23290073
esv2734893 CNV deletion 23290073
esv2759547 CNV gain+loss 17122850
esv2761350 CNV loss 21179565
esv33610 CNV gain+loss 17666407
esv33833 CNV loss 17666407
esv3542157 CNV deletion 23714750
esv3542158 CNV deletion 23714750
esv3572021 CNV loss 25503493
esv3572024 CNV loss 25503493
esv3614304 CNV loss 21293372
esv3614305 CNV loss 21293372
esv3614306 CNV loss 21293372
nsv1020837 CNV loss 25217958
nsv1075983 CNV deletion 25765185
nsv1128350 CNV deletion 24896259
nsv1132079 CNV deletion 24896259
nsv1144196 CNV deletion 24896259
nsv1149912 CNV deletion 26484159
nsv1161590 OTHER complex 26073780
nsv436558 CNV deletion 17901297
nsv442074 CNV loss 18776908
nsv470381 CNV loss 18288195
nsv499699 CNV loss 21111241
nsv514435 CNV loss 21397061
nsv5869 CNV deletion 18451855
nsv607933 CNV gain 21841781
nsv607942 CNV gain+loss 21841781
nsv607944 CNV loss 21841781
nsv607945 CNV loss 21841781
nsv607965 CNV loss 21841781
nsv8184 CNV loss 18304495
nsv831072 CNV loss 17160897
nsv951388 CNV deletion 24416366

Relevant External Links for ZAN Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZAN Gene

Disorders for ZAN Gene

Relevant External Links for ZAN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZAN Gene

Publications for ZAN Gene

  1. Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution. (PMID: 17033959) Gasper J. … Swanson W.J. (Am. J. Hum. Genet. 2006) 2 3 4 22 64
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4 22 64
  3. Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN). (PMID: 9126492) Gao Z. … Garbers D.L. (Genomics 1997) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Zonadhesin D3-polypeptides vary among species but are similar in Equus species capable of interbreeding. (PMID: 19794156) Tardif S. … Hardy D.M. (Biol. Reprod. 2010) 3 22 64

Products for ZAN Gene

Sources for ZAN Gene

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