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ZAN Gene

protein-coding   GIFtS: 50
GCID: GC07P100333

Zonadhesin (Gene/Pseudogene)

(Previous name: zonadhesin)
  See ZAN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zonadhesin (Gene/Pseudogene)1
zonadhesin1 2

External Ids:    HGNC: 128571   Entrez Gene: 74552   Ensembl: ENSG000001468397   OMIM: 6023725   UniProtKB: Q9Y4933   

Export aliases for ZAN gene to outside databases

Previous GC identifers: GC07P098866 GC07P099928 GC07P099943 GC07P099944 GC07P099975 GC07P100169 GC07P099690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZAN Gene:
This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida.
The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition.
Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for ZAN Gene:
ZAN (zonadhesin (gene/pseudogene)) is a protein-coding gene. Diseases associated with ZAN include diffuse panbronchiolitis. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493
Function: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete
recognition and/or signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZAN gene promoter:
         Egr-2   AP-1   RREB-1   p300   Lmo2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZAN promoter sequence
   Search Chromatin IP Primers for ZAN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZAN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ZAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZAN gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100333:  view genomic region     (about GC identifiers)

Start:
100,331,249 bp from pter      End:
100,395,419 bp from pter
Size:
64,171 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,690,854-99,755,024     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493 (See protein sequence)
Recommended Name: Zonadhesin precursor  
Size: 2812 amino acids; 305663 Da
Subunit: Probably forms covalent oligomers
Sequence caution: Sequence=AAC78790.1; Type=Erroneous gene model prediction; Sequence=EAW76487.1; Type=Erroneous
gene model prediction; Sequence=EAW76488.1; Type=Erroneous gene model prediction; Sequence=EAW76489.1;
Type=Erroneous gene model prediction; Sequence=EAW76490.1; Type=Erroneous gene model prediction;
Sequence=EAW76491.1; Type=Erroneous gene model prediction; Sequence=EAW76492.1; Type=Erroneous gene model
prediction;
Secondary accessions: A0FKC8 D6W5W4 O00218 Q96L85 Q96L86 Q96L87 Q96L88 Q96L89 Q96L90 Q9BXN9
Q9BZ83 Q9BZ84 Q9BZ85 Q9BZ86 Q9BZ87 Q9BZ88
Alternative splicing: 7 isoforms:  Q9Y493-1   Q9Y493-2   Q9Y493-3   Q9Y493-4   Q9Y493-5   Q9Y493-6   Q9Y493-7   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZAN: NX_Q9Y493

Explore proteomics data for ZAN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn333, Asn493, Asn1112, Asn1188, Asn1685, Asn1804, Asn1900, Asn1946, Asn2203, Asn2542,
                                 Asn2701
  • Modification sites at PhosphoSitePlus

  • See ZAN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003377.2  NP_775082.2  

    ENSEMBL proteins: 
     ENSP00000422387   ENSP00000425200   ENSP00000421245   ENSP00000425454   ENSP00000422208  
     ENSP00000423579   ENSP00000445943   ENSP00000445091   ENSP00000444427   ENSP00000441117  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR014853 Unchr_dom_Cys-rich
     IPR000742 EG-like_dom
     IPR002919 TIL_dom
     IPR000998 MAM_dom
     IPR025615 TILa_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y493

    ProtoNet protein and cluster: Q9Y493

    5 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like
    IPB006210 Type I EGF
    IPB006552 VC out


    UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493
    Domain: The MAM domains probably mediate sperm adhesion to the zona pellucida
    Domain: During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate
    trapping of spermatozoa or promoting adhesion to the oviductal isthmus
    Domain: The VWFD domain 2 may mediate covalent oligomerization (By similarity)
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 3 MAM domains
    Similarity: Contains 4 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 5 VWFC domains
    Similarity: Contains 4 VWFD domains


    Find genes that share domains with ZAN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZAN_HUMAN, Q9Y493
    Function: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete
    recognition and/or signaling

         Genatlas biochemistry entry for ZAN:
    zonadhesin,sperm membrane protein,binding the zona pellucida

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ZAN           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Zan):
     reproductive system 

    Find genes that share phenotypes with ZAN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zantm1Dmh for ZAN

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    hsa-miR-1323 hsa-miR-548o
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZAN_HUMAN, Q9Y493: Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of
    the sperm head (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane NAS9126492
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ZAN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZAN About    
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sperm Motility0.37

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ZAN
        Sperm Motility


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZAN
    Interactions:

        Search GeneGlobe Interaction Network for ZAN

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007339binding of sperm to zona pellucida NAS9126492
    GO:0016337cell-cell adhesion NAS9126492
    GO:2000359regulation of binding of sperm to zona pellucida ----

    Find genes that share ontologies with ZAN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZAN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZAN gene (6 alternative transcripts): 
    NM_003386.2  NM_173059.2  NM_173055.1  NM_173056.1  NM_173057.1  NM_173058.1  

    Unigene Cluster for ZAN:

    Zonadhesin
    Hs.307004  [show with all ESTs]
    Unigene Representative Sequence: AF332977
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349350(uc003uwj.3) ENST00000427578 ENST00000443370(uc010lhi.3 uc011kke.2)
    ENST00000421100(uc010lhh.3) ENST00000449052(uc003uwl.3) ENST00000348028(uc003uwk.3)
    ENST00000546292(uc011kkd.1) ENST00000538115 ENST00000542585 ENST00000546213

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ZAN:
    hsa-miR-1323 hsa-miR-548o
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZAN
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    Additional mRNA sequence: 

    AF332977.1 AF332980.1 AK302596.1 U83191.1 

    3 DOTS entries:

    DT.99969490  DT.97798990  DT.97763305 

    13 AceView cDNA sequences:

    NM_173058 NM_173055 AF332977 NM_173056 NM_173059 AF332976 NM_003386 AF332979 
    AF332978 AF332980 NM_173057 AF332975 U83191 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZAN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTGCCCA
    ZAN Expression
    About this image

    ZAN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZAN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.307004

    UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493
    Tissue specificity: In testis, primarily in haploid spermatids

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZAN gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zan1 , 5 zonadhesin1, 5 70.13(n)1
    60.08(a)1
      5 (76.40 cM)5
    226351  NM_011741.21  NP_035871.21 
     1373786375 
    chicken
    (Gallus gallus)
    Aves ZAN6
    zonadhesin (gene/pseudogene)
    35(a)
    1 ↔ 1
    9(12628993-12700392) ENSGALG00000007208
    lizard
    (Anolis carolinensis)
    Reptilia ZAN6
    zonadhesin (gene/pseudogene)
    32(a)
    1 ↔ 1
    GL343926.1(1520-45625)
    zebrafish
    (Danio rerio)
    Actinopterygii ZAN6
    zonadhesin (gene/pseudogene)
    36(a)
    1 ↔ 1
    7(27452377-27490514) ENSDARG00000056781
    fruit fly
    (Drosophila melanogaster)
    Insecta cv-26
    crossveinless 2
    17(a)
    1 → many
    2R(17242520-17266967)


    ENSEMBL Gene Tree for ZAN (if available)
    TreeFam Gene Tree for ZAN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZAN gene
    MUC5AC2  TECTA2  MUC22  OTOG2  OTOGL2  MUC62  MUC192  FCGBP2  
    VWF2  BMPER2  
    1 SIMAP similar gene for ZAN using alignment to 5 protein entries:     ZAN_HUMAN (see all proteins):
    FCGBP

    Find genes that share paralogs with ZAN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZAN (see all 1940)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383305231,2
    --99689007(+) GCCAAC/GGTGGG 2 -- us2k10--------
    rs24062571,2
    C,A--99689172(-) aacctT/Ccacct 2 -- us2k14Minor allele frequency- C:0.14NA CSA EA 243
    rs1440738891,2
    --99689206(+) TTGCTC/TTCTAG 2 -- us2k10--------
    rs1117409781,2
    C--99689219(+) GGGTTGACAGA  
      GCGA
    /-
    GACTC
    2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1999840171,2
    C--99689223(+) TTGACA/TCCTCC 2 -- us2k10--------
    rs1159195871,2
    F--99689528(+) AGTAAG/ACTGTG 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs24062561,2
    C,F--99689696(-) cgttcG/Aaggct 2 -- us2k110Minor allele frequency- A:0.19NA WA CSA EA 370
    rs1871921071,2
    --99689929(+) GAGTTC/TGTATC 2 -- us2k10--------
    rs558670011,2
    C,F--99689930(+) AGTTCG/CTATCT 2 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1916487501,2
    --99690088(+) CATGGA/CAAAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZAN (100331249 - 100395419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZAN (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436558CNV Deletion17901297
    esv2145665CNV Deletion18987734
    esv2734893CNV Deletion23290073
    esv2337044CNV Deletion18987734
    dgv1227e199CNV Deletion23128226
    esv2734888CNV Deletion23290073
    esv2674171CNV Deletion23128226
    esv2734892CNV Deletion23290073
    esv2669885CNV Deletion23128226
    esv2648192CNV Deletion19546169

    Human Gene Mutation Database (HGMD): ZAN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZAN
    DNA2.0 Custom Variant and Variant Library Synthesis for ZAN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602372    OMIM disorders: --

    1 disease for ZAN:    
    About MalaCards
    diffuse panbronchiolitis

    1 disease from the University of Copenhagen DISEASES database for ZAN:
    Borderline personality disorder

    Find genes that share disorders with ZAN           About GenesLikeMe

    Genetic Association Database (GAD): ZAN
    Human Genome Epidemiology (HuGE) Navigator: ZAN (5 documents)

    Export disorders for ZAN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZAN gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ZAN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution. (PubMed id 17033959)1, 2, 3, 9 Gasper J. and Swanson W.J. (Am. J. Hum. Genet. 2006)
    2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)1, 2, 3, 9 Gloeckner G.... Rosenthal A. (Genome Res. 1998)
    3. Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN). (PubMed id 9126492)1, 2, 9 Gao Z.... Garbers D.L. (Genomics 1997)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1, 4 Ganesh S.K....Lin J.P. (Nat. Genet. 2009)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    7. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2 Wilson M.D.... Koop B.F. (Nucleic Acids Res. 2001)
    8. Zonadhesin D3-polypeptides vary among species but are similar in Equus species capable of interbreeding. (PubMed id 19794156)1, 9 Tardif S....Hardy D.M. (Biol. Reprod. 2010)
    9. Sequence evolution, processing, and posttranslational modification of zonadhesin D domains in primates, as inferred from cDNA data. (PubMed id 16185823)1, 9 Herlyn H. and Zischler H. (Gene 2005)
    10. Sequence evolution of the sperm ligand zonadhesin correlates negatively with body weight dimorphism in primates. (PubMed id 17348940)1, 9 Herlyn H. and Zischler H. ( international journal of organic evolution 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7455 HGNC: 12857 AceView: ZAN Ensembl:ENSG00000146839 euGenes: HUgn7455
    ECgene: ZAN H-InvDB: ZAN

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZAN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZAN gene:
    Search GeneIP for patents involving ZAN

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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