ZAN Gene
protein-coding GIFtS: 46
GCID: GC07P100333
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zonadhesin
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Aliases for ZAN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
Export aliases for ZAN gene to outside databasesPrevious GC identifers: GC07P098866 GC07P099928 GC07P099943 GC07P099944 GC07P099975 GC07P100169 GC07P099690 |
Summaries for ZAN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ZAN: This gene encodes a sperm membrane protein that binds the zona pellucida of the egg in a species-specific manner. Theencoded protein may be involved in signaling or gamete recognition. Alternate transcriptional splice variants,encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493Function: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognitionand/or signaling
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Genomic Views for ZAN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZAN gene promoter: Egr-2 AP-1 RREB-1 p300 Lmo2 GATA-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ZAN
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZAN |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1ZAN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P100333: view genomic region
(about GC identifiers)
Start:
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100,331,249 bp from pter |
End:
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100,395,419 bp from pter |
Size:
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64,171 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,690,854-99,755,024 |
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Proteins for ZAN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493 (See
protein sequence)Recommended Name: Zonadhesin precursor Size: 2812 amino acids; 305663 Da
Subunit: Probably forms covalent oligomers
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of thesperm head (By similarity)
Sequence caution: Sequence=AAC78790.1; Type=Erroneous gene model prediction; Sequence=EAW76487.1; Type=Erroneous genemodel prediction; Sequence=EAW76488.1; Type=Erroneous gene model prediction; Sequence=EAW76489.1; Type=Erroneous genemodel prediction; Sequence=EAW76490.1; Type=Erroneous gene model prediction; Sequence=EAW76491.1; Type=Erroneous genemodel prediction; Sequence=EAW76492.1; Type=Erroneous gene model prediction;
Secondary accessions: A0FKC8 D6W5W4 O00218 Q96L85 Q96L86 Q96L87 Q96L88 Q96L89 Q96L90 Q9BXN9 Q9BZ83Q9BZ84 Q9BZ85 Q9BZ86 Q9BZ87 Q9BZ88Alternative splicing: 7 isoforms: Q9Y493-1 Q9Y493-2 Q9Y493-3 Q9Y493-4 Q9Y493-5 Q9Y493-6 Q9Y493-7 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for ZAN: NX_Q9Y493
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y493 ZAN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003377.1 NP_775082.1 ENSEMBL proteins: ENSP00000422387 ENSP00000425200 ENSP00000421245 ENSP00000425454 ENSP00000422208 ENSP00000423579 ENSP00000445943 ENSP00000445091 ENSP00000444427 ENSP00000441117 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZAN for ontologies About GeneDecksing
ZAN Antibody Products: Assay Products for ZAN: |
Protein
Domains / Families for ZAN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZAN for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9Y493ProtoNet protein and cluster: Q9Y493 5 Blocks protein families: IPB001007 von Willebrand factor IPB001846 Von Willebrand factor IPB002919 Trypsin inhibitor-like IPB006210 Type I EGF IPB006552 VC out
UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493Domain: The MAM domains probably mediate sperm adhesion to the zona pellucidaDomain: During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriatetrapping of spermatozoa or promoting adhesion to the oviductal isthmusDomain: The VWFD domain 2 may mediate covalent oligomerization (By similarity)Similarity: Contains 1 EGF-like domainSimilarity: Contains 3 MAM domainsSimilarity: Contains 4 TIL (trypsin inhibitory-like) domainsSimilarity: Contains 5 VWFC domainsSimilarity: Contains 4 VWFD domains |
Function for ZAN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493Function: Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognitionand/or signaling Genatlas biochemistry entry for ZAN:zonadhesin,sperm membrane protein,binding the zona pellucida
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZAN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZAN (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZAN (NM_173059) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZAN | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZAN  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAN |
Animal Models: Mouse knock-out Zantm1Dmh for ZAN 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Zan):
ZAN for phenotypes About GeneDecksing
|
Pathways & Interactions for ZAN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sweet Taste Signaling | |
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ZAN
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZAN
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
ZAN for ontologies About GeneDecksing
|
Drugs & Compounds for ZAN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZAN Search CenterWatch for drugs/clinical trials and news about ZAN 
|
Transcripts for ZAN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZAN gene (6 alternative transcripts): NM_003386.1 NM_173059.1 NM_173055.1 NM_173056.1 NM_173057.1 NM_173058.1 Unigene Cluster for ZAN: Zonadhesin Hs.307004 [show with all ESTs]Unigene Representative Sequence: AF33297710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000349350(uc003uwj.3) ENST00000427578 ENST00000443370(uc010lhi.3 uc011kke.2) ENST00000421100(uc010lhh.3) ENST00000449052(uc003uwl.3) ENST00000348028(uc003uwk.3) ENST00000546292(uc011kkd.1) ENST00000538115 ENST00000542585 ENST00000546213
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZAN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZAN (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZAN (NM_173059) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZAN | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZAN  |
Additional cDNA sequence: AF332977.1 AF332980.1 AK302596.1 U83191.1 3 DOTS entries: DT.99969490 DT.97798990 DT.97763305 13 AceView cDNA sequences: NM_173056 NM_003386 AF332975 AF332980 AF332978 NM_173059 AF332979 AF332976 NM_173058 AF332977 NM_173057 NM_173055 U83191 GeneLoc Exon Structure
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Expression for ZAN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZAN expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATGCTGCCCA
About this image See ZAN Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZAN
SOURCE GeneReport for Unigene cluster: Hs.307004 UniProtKB/Swiss-Prot: ZAN_HUMAN, Q9Y493Tissue specificity: In testis, primarily in haploid spermatids SABiosciences Custom PCR Arrays for ZAN
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZAN Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZAN | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZAN | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZAN | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAN |
Orthologs for ZAN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for ZAN gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for ZAN (if available) TreeFam Gene Tree for ZAN (if available)  |
Paralogs for ZAN gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for ZAN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ZAN (100331249 - 100395419 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 20 variations for ZAN 15 CNVs: 3692 94741 36734 94742 22860 44277 82108 64902 38035 7593 4550 7592 100054 82109 32938 5 Indels: 82110 94743 94745 94744 47189 Human Gene Mutation Database (HGMD): ZAN
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZAN |
|
Disorders
/ Diseases for ZAN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZAN for disorders About GeneDecksing
OMIM gene information: 602372
OMIM disorders: --
3 diseases for ZAN: About MalaCardsdiffuse panbronchiolitis panbronchiolitis malaria 1 disease from the University of Copenhagen DISEASES database for ZAN:Borderline personality disorder Human Genome Epidemiology (HuGE) Navigator: ZAN (5 documents) Export disorders for ZAN gene to outside databases
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Publications for ZAN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZAN gene, integrated from 9 sources (see all 22): (articles sorted by number of sources associating them with ZAN) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)1, 2, 3, 9 Gloeckner G.... Rosenthal A. (1998)
- Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution. (PubMed id 17033959)1, 2, 9 Gasper J. and Swanson W.J. (2006)
- Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN). (PubMed id 9126492)1, 2, 9 Gao Z.... Garbers D.L. (1997)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2 Wilson M.D....Koop B.F. (2001)
- Identification of sex hormone binding globulin-intera cting proteins in the brain using phage display screening. (PubMed id 19724880)1, 9 Gnanasekar M....Caldwell J.D. (2009)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PubMed id 19862010)1 Ganesh S.K....Lin J.P. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
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External Searches for ZAN gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing ZAN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZAN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZAN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZAN | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZAN gene: Search GeneIP for patents involving ZAN
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZAN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ZAN | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZAN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZAN | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ZAN | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZAN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZAN | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZAN | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZAN | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZAN | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZAN | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZAN | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZAN |
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 | | ZAN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAN |
|  |  |  | | | Search ThermoFisher Antibodies for ZAN |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ZAN |
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