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Aliases for ZAN Gene

Aliases for ZAN Gene

  • Zonadhesin (Gene/Pseudogene) 2 3 5
  • Zonadhesin 2

External Ids for ZAN Gene

Previous GeneCards Identifiers for ZAN Gene

  • GC07P098866
  • GC07P099928
  • GC07P099943
  • GC07P099944
  • GC07P099975
  • GC07P100169
  • GC07P100333
  • GC07P099690

Summaries for ZAN Gene

Entrez Gene Summary for ZAN Gene

  • This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for ZAN Gene

ZAN (Zonadhesin (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. An important paralog of this gene is OTOG.

UniProtKB/Swiss-Prot for ZAN Gene

  • Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAN Gene

Genomics for ZAN Gene

Regulatory Elements for ZAN Gene

Genomic Location for ZAN Gene

100,733,583 bp from pter
100,797,797 bp from pter
64,215 bases
Plus strand

Genomic View for ZAN Gene

Genes around ZAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAN Gene

Proteins for ZAN Gene

  • Protein details for ZAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0FKC8
    • D6W5W4
    • O00218
    • Q96L85
    • Q96L86
    • Q96L87
    • Q96L88
    • Q96L89
    • Q96L90
    • Q9BXN9
    • Q9BZ83
    • Q9BZ84
    • Q9BZ85
    • Q9BZ86
    • Q9BZ87
    • Q9BZ88

    Protein attributes for ZAN Gene

    2812 amino acids
    Molecular mass:
    305663 Da
    Quaternary structure:
    • Probably forms covalent oligomers.
    • Sequence=AAC78790.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76487.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76489.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76491.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW76492.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZAN Gene

neXtProt entry for ZAN Gene

Proteomics data for ZAN Gene at MOPED

Post-translational modifications for ZAN Gene

  • Glycosylation at Asn 333, Asn 493, Asn 1112, Asn 1188, Asn 1685, Asn 1804, Asn 1900, Asn 1946, Asn 2203, Asn 2542, and Asn 2701
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZAN Gene

Domains & Families for ZAN Gene

Suggested Antigen Peptide Sequences for ZAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
  • The MAM domains probably mediate sperm adhesion to the zona pellucida.
  • During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
  • The VWFD domain 2 may mediate covalent oligomerization.
  • Contains 1 EGF-like domain.
  • Contains 3 MAM domains.
  • Contains 4 TIL (trypsin inhibitory-like) domains.
  • Contains 5 VWFC domains.
  • Contains 4 VWFD domains.
genes like me logo Genes that share domains with ZAN: view

No data available for Gene Families for ZAN Gene

Function for ZAN Gene

Molecular function for ZAN Gene

GENATLAS Biochemistry:
zonadhesin,sperm membrane protein,binding the zona pellucida
UniProtKB/Swiss-Prot Function:
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
genes like me logo Genes that share phenotypes with ZAN: view

Animal Models for ZAN Gene

MGI Knock Outs for ZAN:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ZAN Gene

Localization for ZAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAN Gene

Cell membrane; Single-pass type I membrane protein. Note=Exclusively on the apical region of the sperm head. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 9126492
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZAN: view

No data available for Subcellular locations from COMPARTMENTS for ZAN Gene

Pathways & Interactions for ZAN Gene

SuperPathways for ZAN Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with ZAN: view

Pathways by source for ZAN Gene

1 Qiagen pathway for ZAN Gene

Interacting Proteins for ZAN Gene

Gene Ontology (GO) - Biological Process for ZAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion NAS 9126492
genes like me logo Genes that share ontologies with ZAN: view

No data available for SIGNOR curated interactions for ZAN Gene

Drugs & Compounds for ZAN Gene

No Compound Related Data Available

Transcripts for ZAN Gene

mRNA/cDNA for ZAN Gene

Unigene Clusters for ZAN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZAN Gene

No ASD Table

Relevant External Links for ZAN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZAN Gene

mRNA expression in normal human tissues for ZAN Gene

mRNA differential expression in normal tissues according to GTEx for ZAN Gene

This gene is overexpressed in Testis (x43.6).

Protein differential expression in normal tissues from HIPED for ZAN Gene

This gene is overexpressed in Pancreas (54.6) and Lung (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZAN Gene

SOURCE GeneReport for Unigene cluster for ZAN Gene Hs.307004

mRNA Expression by UniProt/SwissProt for ZAN Gene

Tissue specificity: In testis, primarily in haploid spermatids.
genes like me logo Genes that share expression patterns with ZAN: view

Protein tissue co-expression partners for ZAN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZAN Gene

Orthologs for ZAN Gene

This gene was present in the common ancestor of animals.

Orthologs for ZAN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZAN 35
  • 75.03 (n)
  • 64.75 (a)
ZAN 36
  • 60 (a)
(Mus musculus)
Mammalia Zan 35
  • 70.13 (n)
  • 60.08 (a)
Zan 16
Zan 36
  • 30 (a)
(Pan troglodytes)
Mammalia ZAN 35
  • 97.45 (n)
  • 95.09 (a)
(Rattus norvegicus)
Mammalia Zan 35
  • 67.95 (n)
  • 57.62 (a)
(Canis familiaris)
Mammalia ZAN 36
  • 62 (a)
(Monodelphis domestica)
Mammalia ZAN 36
  • 22 (a)
(Ornithorhynchus anatinus)
Mammalia ZAN 36
  • 48 (a)
(Gallus gallus)
Aves ZAN 36
  • 35 (a)
(Anolis carolinensis)
Reptilia ZAN 36
  • 32 (a)
(Danio rerio)
Actinopterygii ZAN 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta cv-2 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
Species with no ortholog for ZAN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAN Gene

Gene Tree for ZAN (if available)
Gene Tree for ZAN (if available)

Paralogs for ZAN Gene

Paralogs for ZAN Gene

(1) SIMAP similar genes for ZAN Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZAN: view

Variants for ZAN Gene

Sequence variations from dbSNP and Humsavar for ZAN Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17162408 - 100,748,455(+) CGGGA(A/G/T)GTTTC nc-transcript-variant, reference, missense
rs13241461 - 100,752,174(+) ACCCA(C/G)CATCC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs6942733 - 100,753,140(+) TGGGC(A/G/T)GGCAG nc-transcript-variant, reference, missense
rs221823 - 100,755,388(-) TGTAG(A/C)AGCAA nc-transcript-variant, reference, missense
rs2293767 - 100,764,052(-) GGAAG(C/T)GGCCT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZAN Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
nsv831072 CNV Loss 17160897
nsv888791 CNV Loss 21882294
nsv470381 CNV Loss 18288195
nsv8184 CNV Loss 18304495
nsv888796 CNV Loss 21882294
esv33610 CNV Gain+Loss 17666407
nsv5869 CNV Loss 18451855
dgv1227e199 CNV Deletion 23128226
nsv436558 CNV Deletion 17901297
esv2734892 CNV Deletion 23290073
nsv499699 CNV Loss 21111241
dgv1126n67 CNV Loss 20364138
esv22712 CNV Loss 19812545
nsv442074 CNV CNV 18776908
nsv514435 CNV Loss 21397061
esv2337044 CNV Deletion 18987734
esv2648192 CNV Deletion 19546169
esv2145665 CNV Deletion 18987734
esv2669885 CNV Deletion 23128226
esv2674171 CNV Deletion 23128226
esv33833 CNV Loss 17666407
esv2734893 CNV Deletion 23290073
dgv2119e1 CNV Complex 17122850
dgv7402n71 CNV Loss 21882294

Relevant External Links for ZAN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZAN Gene

Disorders for ZAN Gene

Relevant External Links for ZAN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZAN Gene

Publications for ZAN Gene

  1. Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution. (PMID: 17033959) Gasper J. … Swanson W.J. (Am. J. Hum. Genet. 2006) 2 3 4 23 67
  2. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 23
  3. Zonadhesin D3-polypeptides vary among species but are similar in Equus species capable of interbreeding. (PMID: 19794156) Tardif S. … Hardy D.M. (Biol. Reprod. 2010) 3 23
  4. Identification of sex hormone binding globulin-interacting proteins in the brain using phage display screening. (PMID: 19724880) Gnanasekar M. … Caldwell J.D. (Int. J. Mol. Med. 2009) 3 23
  5. Sequence evolution of the sperm ligand zonadhesin correlates negatively with body weight dimorphism in primates. (PMID: 17348940) Herlyn H. … Zischler H. (Evolution 2007) 3 23

Products for ZAN Gene

Sources for ZAN Gene

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