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ZAK Gene

protein-coding   GIFtS: 56
GCID: GC02P173940

Sterile Alpha Motif And Leucine Zipper Containing Kinase...


  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MLTK2 3 5     Mixed Lineage Kinase-Related Kinase MRK-Beta2
MRK2 3 5     mlklak2
Human Cervical Cancer Suppressor Gene 4 Protein2 3     pk2
HCCS-42 3     Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK2
MLK-Like Mitogen-Activated Protein Triple Kinase2 3     EC 2.7.11.253
AZK2     Leucine Zipper- And Sterile Alpha Motif-Containing Kinase3
MLK72     Mixed Lineage Kinase-Related Kinase3
MLT2     MLK-Related Kinase3
Mitogen-Activated Protein Kinase Kinase Kinase MLT2     Sterile Alpha Motif- And Leucine Zipper-Containing Kinase AZK3
Mixed Lineage Kinase 72     EC 2.7.118
Mixed Lineage Kinase With A Leucine Zipper And A Sterile Alpha Motif2     

External Ids:    Entrez Gene: 517762   Ensembl: ENSG000000914367   OMIM: 6094795   UniProtKB: Q9NYL23   

Export aliases for ZAK gene to outside databases

Previous GC identifers: GC02P171993 GC02P172601 GC02P173904 GC02P174143 GC02P173766 GC02P173648 GC02P165819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZAK Gene:
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an
N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This
magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation
signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint
regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ZAK Gene:
ZAK is a protein-coding gene. Diseases associated with ZAK include cervical cancer, and cervicitis. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase kinase activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38
pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2.
Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have
role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates
histone H3 at 'Ser-28'

Gene Wiki entry for ZAK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZAK gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   CUTL1   E2F-2   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZAK promoter sequence
   Search Chromatin IP Primers for ZAK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZAK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q31.1   

ZAK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZAK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P173940:  view genomic region     (about GC identifiers)

Start:
173,940,163 bp from pter      End:
174,132,738 bp from pter
Size:
192,576 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase MLT  
Size: 800 amino acids; 91155 Da
Cofactor: Magnesium
Subunit: Homodimer. Interacts with PKN1 and ZNF33A
Sequence caution: Sequence=BAD92211.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KPG2 Q53SX1 Q580W8 Q59GY5 Q86YW8 Q9HCC4 Q9HCC5 Q9HDD2 Q9NYE9
Alternative splicing: 3 isoforms:  Q9NYL2-1   Q9NYL2-2   Q9NYL2-3   (Contains a phosphoserine at position 339. Contains a phosphoserine at position 429. Contains a phosphoserine at position 434. Contains a phosphoserine at position 454)

Explore the universe of human proteins at neXtProt for ZAK: NX_Q9NYL2

Explore proteomics data for ZAK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ZAK (Q9NYL2)
     VIHRDLK  LKICDFG  WMAPEVI 


    See ZAK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057737.2  NP_598407.1  

    ENSEMBL proteins: 
     ENSP00000387259   ENSP00000340257   ENSP00000364361   ENSP00000411923   ENSP00000439414  
     ENSP00000399787  

    ZAK Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ZAK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ZAK sterile alpha motif and leucine zipper containing kinase AZK
    MLK subfamily

    Selected InterPro protein domains (see all 8):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR028429 MLTK
     IPR021129 SAM_type1
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYL2

    ProtoNet protein and cluster: Q9NYL2

    2 Blocks protein domains:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    ZAK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLTK_HUMAN, Q9NYL2
    Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38
    pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2.
    Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have
    role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates
    histone H3 at 'Ser-28'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.251

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA11836244
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11836244
    GO:0004709MAP kinase kinase kinase activity IDA11836244
    GO:0004713protein tyrosine kinase activity ----
         
    ZAK for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for ZAK:
     Decreased substrate adherent c  Increased Salmonella enterica   Increased mitotic index  Reduced beta-catenin activity  
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZAK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZAK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZAK

    miRNA
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    Block miRNA regulation of human, mouse, rat ZAK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZAK (see all 96):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-342-3p hsa-miR-550a* hsa-miR-890
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZAK
    Predesigned siRNA for gene silencing in human, mouse, rat ZAK

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZAK (NM_016653)
    Sino Biological Human cDNA Clone for ZAK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZAK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZAK

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MLTK_HUMAN, Q9NYL2: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS--

    ZAK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZAK About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3G protein signaling Regulation of p38 and JNK signaling mediated by G proteins
    G protein signaling Regulation of p38 and JNK signaling mediated by G proteins0.40
    4Tight junction
    Tight junction
    5Signaling mediated by p38-gamma and p38-delta
    Signaling mediated by p38-gamma and p38-delta

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ZAK
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    1 GeneGo (Thomson Reuters) Pathway for ZAK
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

    2 BioSystems Pathways for ZAK
        MAPK signaling pathway
    Signaling mediated by p38-gamma and p38-delta



    2 Kegg Pathways  (Kegg details for ZAK):
        MAPK signaling pathway
    Tight junction


    ZAK for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZAK: 
              Tight Junctions in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ZAK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ZAK (Q9NYL21, 2, 3 ENSP000003643614) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDAH2O958652, 3MINT-8277258 I2D: score=2 
    ENSG00000206395O958652, 3MINT-8277258 I2D: score=2 
    ENSG00000225635O958652, 3MINT-8277258 I2D: score=2 
    ENSG00000226634O958652, 3MINT-8277258 I2D: score=2 
    ENSG00000227317O958652, 3MINT-8277258 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint IDA15342622
    GO:0000077DNA damage checkpoint IMP11836244
    GO:0000165MAPK cascade ----
    GO:0000186activation of MAPKK activity TAS11836244
    GO:0006468protein phosphorylation IDA11836244

    ZAK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZAK (MLTK)

    3 Novoseek inferred chemical compound relationships for ZAK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 34.3 4 11549352 (1)
    threonine 33.3 1 11549352 (1)
    serine 18.8 1 11549352 (1)



    ZAK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZAK gene (2 alternative transcripts): 
    NM_016653.2  NM_133646.2  

    Unigene Cluster for ZAK:

    Sterile alpha motif and leucine zipper containing kinase AZK
    Hs.444451  [show with all ESTs]
    Unigene Representative Sequence: AF480462
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409176 ENST00000468408 ENST00000338983(uc002uhy.3 uc010zei.2)
    ENST00000476618(uc002uhx.3) ENST00000375213(uc002uhz.3) ENST00000422149
    ENST00000480606 ENST00000539448 ENST00000431503
    miRNA
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    Block miRNA regulation of human, mouse, rat ZAK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZAK (see all 96):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-342-3p hsa-miR-550a* hsa-miR-890
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZAK (NM_016653)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZAK
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZAK
      QuantiTect SYBR Green Assays in human, mouse, rat ZAK
      QuantiFast Probe-based Assays in human, mouse, rat ZAK

    Additional mRNA sequence: 

    AB030034.1 AB041883.1 AB049733.1 AB049734.1 AB208974.1 AF238255.1 AF251441.1 AF325454.1 
    AF465843.1 AF480461.1 AF480462.1 AK056310.1 AK095825.1 AK096877.1 AK291825.1 AK298634.1 
    AL833180.1 BC001401.2 

    10 DOTS entries:

    DT.423171  DT.452501  DT.87016635  DT.100783996  DT.91811205  DT.100678385  DT.120976575  DT.100028728 
    DT.95167694  DT.99932386 

    Selected AceView cDNA sequences (see all 380):

    AA358379 CF553006 BU622301 AI372876 AI889618 AI129413 Z25330 CA435409 
    CA442724 AW769151 AA232750 AW513475 AL600929 BF725880 AW591192 AK056310 
    CA394113 AB049733 AA436815 AI129320 AA244505 CR598198 AA947162 BF439428 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZAK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGTAACCC
    ZAK Expression
    About this image


    ZAK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Ovary (Reproductive System)
     
     Adipose (Muscoskeletal System)
     
     Esophagus (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ZAK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZAK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444451

    UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
    Tissue specificity: Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for
    liver, in which isoform 1 is more highly expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ZAK: 
              Tight Junctions in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ZAK
    OriGene qSTAR qPCR primer pairs in human, mouse for ZAK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZAK
    QuantiTect SYBR Green Assays in human, mouse, rat ZAK
    QuantiFast Probe-based Assays in human, mouse, rat ZAK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZAK gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia B230120H23Rik5
    Zak1
    RIKEN cDNA B230120H23 gene5
    sterile alpha motif and leucine zipper containing kinase more1
    87.65(n)1
    92.24(a)1
      2 (43.11 cM)5
    659641  NM_023057.51  NP_075544.11 
     722856375 
    chicken
    (Gallus gallus)
    Aves ZAK1 sterile alpha motif and leucine zipper containing kinase more 75.02(n)
    76.46(a)
      424149  XM_421996.4  XP_421996.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343316.1(1086571-1239908)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL898835.22   -- 81.39(n)    AL898835.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-15i8.31 si:dkey-15i8.3 63.16(n)
    63.29(a)
      559247  XM_682568.3  XP_687660.2 


    ENSEMBL Gene Tree for ZAK (if available)
    TreeFam Gene Tree for ZAK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZAK gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    BRAF2  MAP3K92  MAP3K102  ARAF2  MAP3K72  TNNI3K2  MAP3K132  ILK2  
    Selected SIMAP similar genes for ZAK using alignment to 3 protein entries:     MLTK_HUMAN (see all proteins) (see all similar genes):
    pk    SRC    HCK    BLK    MAP3K12    TNNI3K
    MAP3K9    FPGT-TNNI3K    FGR    TNIK    BTK kinase deficient isoform 6    RAF1
    tec    EGFR    BRAF    MAP4K4    MARK2    NEK11

    ZAK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZAK (see all 3787)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714033511,2
    C--165818270(+) ATACAT/-TTTTT 2 -- us2k11Minor allele frequency- -:0.50NA 2
    rs771295251,2
    --165825235(+) ACAAAG/TTTTTT 2 -- int11Minor allele frequency- T:0.50NA 2
    rs724698381,2
    C--165831899(+) AGATA-/TGTGTGT 2 -- int10--------
    rs2016945621,2
    C--165831900(+) GATATA/GTGTGT 2 -- int10--------
    rs356339071,2
    C--165834619(+) AGTCA-/TAACGTT 2 -- int10--------
    rs559475211,2
    C--165839542(+) TTAGAC/-TTTTT 2 -- int11Minor allele frequency- -:0.50NA 2
    rs1844901051,2
    --165854408(+) GGATCC/TTGCTT 2 -- int10--------
    rs1431794691,2
    C--165885341(+) ACTAA-/ATTAT 
            
    ATTCT
    2 -- int10--------
    rs798276621,2
    F--165888612(+) AAAAAG/AAAAAA 2 -- int12Minor allele frequency- A:0.50NA 4
    rs560844351,2
    --165903443(+) TTTGTA/CACCCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZAK (173940163 - 174132738 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZAK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3037CNV Insertion18451855
    nsv3036CNV Insertion18451855
    nsv834461CNV Loss17160897
    nsv834460CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609479    OMIM disorders: --

    4 diseases for ZAK:    
    About MalaCards
    cervical cancer    cervicitis    giant cell tumor    lung cancer


    ZAK for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ZAK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 47 3 15485649 (1), 19184368 (1), 15465036 (1)
    cardiac hypertrophy 43.9 2 11549352 (1), 15465036 (1)

    Genetic Association Database (GAD): ZAK
    Human Genome Epidemiology (HuGE) Navigator: ZAK (28 documents)

    Export disorders for ZAK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZAK gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with ZAK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. (PubMed id 11836244)1, 2, 9 Gross E.A.... Ruggieri R. (J. Biol. Chem. 2002)
    2. Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. (PubMed id 11549352)1, 2, 9 Bloem L.J.... Wang X. (J. Mol. Cell. Cardiol. 2001)
    3. Identification and characterization of a novel MAP kinase kinase kinase, MLTK. (PubMed id 11042189)1, 2, 9 Gotoh I.... Nishida E. (J. Biol. Chem. 2001)
    4. Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. (PubMed id 10924358)1, 2, 9 Liu T.-C.... Yang J.-J. (Biochem. Biophys. Res. Commun. 2000)
    5. Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. (PubMed id 12761180)1, 2, 9 Takahashi M.... Ono Y. (J. Biochem. 2003)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. (PubMed id 15684425)1, 2 Choi H.S.... Dong Z. (J. Biol. Chem. 2005)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. (PubMed id 15342622)1, 2 Tosti E.... Ruggieri R. (J. Biol. Chem. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51776 AceView: ZAK Ensembl:ENSG00000091436 euGenes: HUgn51776 Kegg: 51776

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZAK gene:
    Search GeneIP for patents involving ZAK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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