Aliases for ZAK Gene
- Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK 3
- Sterile Alpha Motif- And Leucine Zipper-Containing Kinase AZK 3 4
- Mitogen-Activated Protein Kinase Kinase Kinase MLT 3 5
- MLK-Like Mitogen-Activated Protein Triple Kinase 3 4
- Human Cervical Cancer Suppressor Gene 4 Protein 3 4
- HCCS-4 3 4
- MLTK 3 4
- MRK 3 4
- Mixed Lineage Kinase With A Leucine Zipper And A Sterile Alpha Motif 3
- Leucine Zipper- And Sterile Alpha Motif-Containing Kinase 4
- Mixed Lineage Kinase-Related Kinase MRK-Beta 3
- Mixed Lineage Kinase-Related Kinase 4
External Ids for ZAK Gene
Previous GeneCards Identifiers for ZAK Gene
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZAK Gene
ZAK (Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK) is a Protein Coding gene. Diseases associated with ZAK include Split-Foot Malformation With Mesoaxial Polydactyly and Split Foot. Among its related pathways are Tight junction and MAPK signaling pathway. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is MAP3K9.
UniProtKB/Swiss-Prot for ZAK Gene
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
Isoform 1: Phosphorylates histone H3 at Ser-28 (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).