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Aliases for ZAK Gene

Aliases for ZAK Gene

  • Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK 3
  • MLTK 3 4 6
  • MRK 3 4 6
  • MLK-Like Mitogen-Activated Protein Triple Kinase 3 4
  • Human Cervical Cancer Suppressor Gene 4 Protein 3 4
  • HCCS-4 3 4
  • Mixed Lineage Kinase With A Leucine Zipper And A Sterile Alpha Motif 3
  • Sterile Alpha Motif- And Leucine Zipper-Containing Kinase AZK 4
  • Leucine Zipper- And Sterile Alpha Motif-Containing Kinase 4
  • Mitogen-Activated Protein Kinase Kinase Kinase MLT 3
  • Mixed Lineage Kinase-Related Kinase MRK-Beta 3
  • Mixed Lineage Kinase-Related Kinase 4
  • Mixed Lineage Kinase 7 3
  • MLK-Related Kinase 4
  • EC 2.7.11.25 4
  • EC 2.7.11 63
  • Mlklak 3
  • MLK7 3
  • AZK 3
  • MLT 3
  • Pk 3

External Ids for ZAK Gene

Previous GeneCards Identifiers for ZAK Gene

  • GC02P171993
  • GC02P172601
  • GC02P173904
  • GC02P174143
  • GC02P173766
  • GC02P173648
  • GC02P165819
  • GC02P173940

Summaries for ZAK Gene

Entrez Gene Summary for ZAK Gene

  • This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZAK Gene

ZAK (Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and MAPK signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for ZAK Gene

  • Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at Ser-28.

Gene Wiki entry for ZAK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZAK Gene

Genomics for ZAK Gene

Regulatory Elements for ZAK Gene

Genomic Location for ZAK Gene

Start:
173,075,435 bp from pter
End:
173,268,010 bp from pter
Size:
192,576 bases
Orientation:
Plus strand

Genomic View for ZAK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZAK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZAK Gene

Proteins for ZAK Gene

  • Protein details for ZAK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL2-MLTK_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase MLT
    Protein Accession:
    Q9NYL2
    Secondary Accessions:
    • B3KPG2
    • Q53SX1
    • Q580W8
    • Q59GY5
    • Q86YW8
    • Q9HCC4
    • Q9HCC5
    • Q9HDD2
    • Q9NYE9

    Protein attributes for ZAK Gene

    Size:
    800 amino acids
    Molecular mass:
    91155 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with PKN1 and ZNF33A.
    SequenceCaution:
    • Sequence=BAD92211.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZAK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZAK Gene

Proteomics data for ZAK Gene at MOPED

Selected DME Specific Peptides for ZAK Gene

Post-translational modifications for ZAK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZAK Gene

Domains for ZAK Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYL2

UniProtKB/Swiss-Prot:

MLTK_HUMAN :
  • Q9NYL2
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with ZAK: view

No data available for Suggested Antigen Peptide Sequences for ZAK Gene

Function for ZAK Gene

Molecular function for ZAK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.
UniProtKB/Swiss-Prot Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at Ser-28.

Enzyme Numbers (IUBMB) for ZAK Gene

Gene Ontology (GO) - Molecular Function for ZAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 11836244
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 11836244
GO:0004709 MAP kinase kinase kinase activity IDA 11836244
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with ZAK: view
genes like me logo Genes that share phenotypes with ZAK: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZAK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZAK Gene

Localization for ZAK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZAK Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation.

Gene Ontology (GO) - Cellular Components for ZAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ZAK: view

No data available for Subcellular locations from COMPARTMENTS for ZAK Gene

Pathways for ZAK Gene

genes like me logo Genes that share pathways with ZAK: view

Pathways by source for ZAK Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ZAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint IDA 15342622
GO:0000077 DNA damage checkpoint IMP 11836244
GO:0000186 activation of MAPKK activity TAS 11836244
GO:0006468 protein phosphorylation IDA 11836244
GO:0006950 response to stress NAS 11836244
genes like me logo Genes that share ontologies with ZAK: view

Compounds for ZAK Gene

(3) Novoseek inferred chemical compound relationships for ZAK Gene

Compound -log(P) Hits PubMed IDs
leucine 34.3 1
threonine 33.3 1
serine 18.8 1
genes like me logo Genes that share compounds with ZAK: view

Transcripts for ZAK Gene

Unigene Clusters for ZAK Gene

Sterile alpha motif and leucine zipper containing kinase AZK:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZAK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZAK Gene

No ASD Table

Relevant External Links for ZAK Gene

GeneLoc Exon Structure for
ZAK

Expression for ZAK Gene

mRNA expression in normal human tissues for ZAK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZAK Gene

This gene is overexpressed in Muscle - Skeletal (8.2) and Heart - Left Ventricle (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZAK Gene

SOURCE GeneReport for Unigene cluster for ZAK Gene Hs.444451

mRNA Expression by UniProt/SwissProt for ZAK Gene

Q9NYL2-MLTK_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
genes like me logo Genes that share expressions with ZAK: view

In Situ Assay Products

Orthologs for ZAK Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZAK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC459745 35
  • 99.54 (n)
  • 99.5 (a)
ZAK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 92 (a)
OneToOne
ZAK 35
  • 90.92 (n)
  • 92.62 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToOne
ZAK 35
  • 91.12 (n)
  • 92.12 (a)
mouse
(Mus musculus)
Mammalia B230120H23Rik 16
Zak 35
  • 87.65 (n)
  • 92.24 (a)
Zak 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zak 35
  • 86.13 (n)
  • 91.86 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 72 (a)
OneToOne
ZAK 35
  • 75.02 (n)
  • 76.46 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495797 35
  • 70.25 (n)
  • 72.32 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-15i8.3 35
  • 63.16 (n)
  • 63.29 (a)
zak 36
  • 63 (a)
OneToMany
zak 36
  • 59 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for ZAK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZAK Gene

ENSEMBL:
Gene Tree for ZAK (if available)
TreeFam:
Gene Tree for ZAK (if available)

Paralogs for ZAK Gene

genes like me logo Genes that share paralogs with ZAK: view

Variants for ZAK Gene

Sequence variations from dbSNP and Humsavar for ZAK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs722864 -- 173,118,476(-) CCCCC(A/C/G/T)CAAAA intron-variant
rs734993 -- 173,161,271(+) AGTGA(A/C)CTAGT intron-variant
rs744075 -- 173,162,126(-) TATTG(G/T)GGTCA intron-variant
rs744076 -- 173,162,110(-) TTCTA(A/C)GTGGC intron-variant
rs746179 -- 173,161,596(+) ATTTT(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZAK Gene

Variant ID Type Subtype PubMed ID
nsv834460 CNV Gain 17160897
nsv3036 CNV Insertion 18451855
nsv834461 CNV Loss 17160897
nsv3037 CNV Insertion 18451855

Relevant External Links for ZAK Gene

HapMap Linkage Disequilibrium report
ZAK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZAK Gene

Disorders for ZAK Gene

(2) Novoseek inferred disease relationships for ZAK Gene

Disease -log(P) Hits PubMed IDs
hypertrophy 47 3
cardiac hypertrophy 43.9 2

Relevant External Links for ZAK

Genetic Association Database (GAD)
ZAK
Human Genome Epidemiology (HuGE) Navigator
ZAK
genes like me logo Genes that share disorders with ZAK: view

No data available for UniProtKB/Swiss-Prot for ZAK Gene

Publications for ZAK Gene

  1. Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. (PMID: 10924358) Liu T.-C. … Yang J.-J. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  2. Identification and characterization of a novel MAP kinase kinase kinase, MLTK. (PMID: 11042189) Gotoh I. … Nishida E. (J. Biol. Chem. 2001) 3 4 23
  3. Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. (PMID: 11549352) Bloem L.J. … Wang X. (J. Mol. Cell. Cardiol. 2001) 3 4 23
  4. MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. (PMID: 11836244) Gross E.A. … Ruggieri R. (J. Biol. Chem. 2002) 3 4 23
  5. Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. (PMID: 12761180) Takahashi M. … Ono Y. (J. Biochem. 2003) 3 4 23

Products for ZAK Gene

  • Addgene plasmids for ZAK

Sources for ZAK Gene

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