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ZAK Gene

protein-coding GIFtS: 54

GC02P173648

sterile alpha motif and leucine zipper containing kinase AZK
symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AZK ^²
EC 2.7.11.25 ^³
HCCS-4 ^³
MLK7 ^²
MLT ^²
MLTK ^², ⁵
MRK ^², ³, ⁵
mlklak ^²

Descriptions
Cervical cancer suppressor gene 4 protein ^², ³
Leucine zipper- and sterile alpha motif-containing kinase ^², ³
MLK-like mitogen-activated protein triple kinase ^², ³
MLK-related kinase ^², ³
Mixed lineage kinase-related kinase ^³
Sterile alpha motif- and leucine zipper-containing kinase AZK ^³
mitogen-activated protein kinase kinase kinase MLT ^²
mixed lineage kinase 7 ^²
mixed lineage kinase with a leucine zipper and a sterile alpha motif ^²
mixed lineage kinase-related kinase MRK-beta ^²
sterile alpha motif and leucine zipper containing kinase AZK ^²

External Ids
Entrez Gene: 51776²
UniProtKB: Q9NYL2³
Ensembl: ENSG00000091436⁷

Search outside databases for aliases for ZAK gene

Previous GC identifers: GC02P171993 GC02P172601 GC02P173904 GC02P174143 GC02P173766

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ZAK:

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein

with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha

motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The

protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this

protein plays a role in cell cycle checkpoint regulation in cells. The protein also has

pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms,

have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2

Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the

JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by

direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and

disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and

cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'

Gene Wiki entry for ZAK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZAK gene

Entrez Gene cytogenetic band: 2q24.2 Ensembl cytogenetic band: 2q31.1

ZAK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P173648: (about GC identifiers)

Start:	173,648,688 bp from pter
End:	173,840,983 bp from pter
Size:	192,296 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase kinase kinase MLT

Size: 800 amino acids; 91181 Da

Cofactor: Magnesium

Subunit: Homodimer. Interacts with PKN1 and ZNF33A

Subcellular location: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B

irradiation

Secondary accessions: Q53SX1 Q580W8 Q59GY5 Q86YW8 Q9HCC4 Q9HCC5 Q9HDD2 Q9NYE9

Alternative splicing: 3 isoforms: Q9NYL2-1 Q9NYL2-2 Q9NYL2-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_057737.2 NP_598407.1

ENSEMBL proteins:

ENSP00000364361 ENSP00000387259 ENSP00000340257

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ZAK
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZAK)
	Human Recombinant Proteins from Abnova (ZAK)

OriGene Purified Recombinant Human Protein: ZAK

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	ISS	--

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Antibodies for ZAK:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZAK
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZAK), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ZAK)
	Novus Biologicals Antibodies for ZAK

Assays for ZAK:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NYL2

ProtoNet protein and cluster: Q9NYL2

2 Blocks protein families:

IPB001660 Sterile alpha motif SAM

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP

kinase kinase kinase subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZAK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZAK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016653

Applied Biosystems Silencer® siRNAs for ZAK

Sigma-Aldrich siRNA and siRNA Panels for ZAK

Sigma-Aldrich shRNA Panels and shRNA for ZAK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_016653
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_016653
untagged cDNA clones in CMV expression vector (see all 2): NM_016653

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016653

UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2

Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the

JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by

direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and

disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and

cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and

Ser-165

Enzyme Number (IUBMB): EC 2.7.11.25

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IDA	11836244
GO:0004674	protein serine/threonine kinase activity	IDA	11836244
GO:0004709	MAP kinase kinase kinase activity	IDA	11836244
GO:0004713	protein tyrosine kinase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ZAK (Your Favorite Gene powered by Ingenuity)

SAPK/JNK Signaling

GeneDecks ZAK for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ZAK

5/9 Interacting proteins for ZAK (ENSP00000364361³ Q9NYL2^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PKN1	Q16512¹	STRING (score=.91) EBI-687346, EBI-602382
ZAK	Q9NYL2¹	EBI-602273, EBI-602273
SFN	P31947²	MINT-3975752
ZNF567	Q8N184²	MINT-67507
ZNF33A	ENSP00000304268³	STRING (score=.994)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	IDA	15342622
GO:0000077	DNA damage checkpoint	IMP	11836244
GO:0000186	activation of MAPKK activity	TAS	11836244
GO:0006950	response to stress	NAS	11836244
GO:0007049	cell cycle	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZAK
2 Novoseek chemical compound relationships for ZAK gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	34.89	4	11549352 (1)
threonine	34.04	1	11549352 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZAK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZAK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016653

Sigma-Aldrich siRNA and siRNA Panels for ZAK

Sigma-Aldrich shRNA Panels and shRNA for ZAK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_016653 NM_133646

REFSEQ mRNAs for ZAK gene (2 alternative transcripts):

NM_016653.2 NM_133646.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_016653 NM_133646

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_016653
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_016653
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_016653

Additional cDNA sequence:

AB030034.1 AB049733.1 AB049734.1 AB208974.1 AF238255.1 AF251441.1 AF325454.1 AF465843.1

AF480461.1 AF480462.1 AK056310.1 AK095825.1 AK096877.1 AK291825.1 AK298634.1 AL833180.1

BC001401.2 CR598198.1 CR606268.1

10 DOTS entries:

DT.423171 DT.452501 DT.87016635 DT.100783996 DT.91811205 DT.100678385 DT.120976575 DT.100028728

DT.95167694 DT.99932386

24/380 AceView cDNA sequences (see all 380 ):

BF439428 AW028962 AW502467 BG119452 BU620051 BU608932 CN479035 AI468464

BC001401 AA307684 BQ775913 R91202 AI129413 BF371663 BF508076 AB049734

CB988989 AI066646 CD676494 AI023521 AA358379 AI372876 BF725880 AI129320

highest scoring ESTs for ZAK:

AI799498 N95341 AA100075 AA236466 AA258354 AA307684 AA402496 AA402558 AA505991 AA626441

Unigene Cluster for ZAK:

Sterile alpha motif and leucine zipper containing kinase AZK

Hs.444451 [show with all ESTs]

Unigene Representative Sequence: AF480462

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000375213 ENST00000409176 ENST00000338983

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ZAK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZAK

¹ / ² / ³

20 probe-sets matching ZAK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76950_at²^{, 3}	U95-E	1	1.00	1.00	0.85	0.66	AI129413	0.60	1.00	0.82	1
60464_at²^{, 3}	U95-C	1	1.00	1.00	0.02	1.02	AI799498	1.00	1.00	1.00	1
85944_at²^{, 3}	U95-E	1	1.00	1.00	0.82	0.76	AA307684	0.80	1.00	0.91	1
61778_at²^{, 3}	U95-C	1	1.00	1.00	-0.18	0.87	N95341	1.00	1.00	1.00	1
48980_at²^{, 3}	U95-C	1	1.00	1.00	0.93	1.24	AI375684	0.80	1.00	0.91	1
54713_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.60	AI129320	0.80	1.00	0.91	1
65702_at²^{, 3}	U95-C	1	1.00	1.00	0.96	1.03	AA425744	0.60	1.00	0.82	1
225665_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI129320	0.80	1.00	0.91	1
225662_at²^{, 3}	U133-B	1	1.00	1.00	--	--	H28667	0.60	1.00	0.82	1
238613_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI475164	0.40	1.00	0.76	1
222757_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB030034	0.80	1.00	0.91	1
223519_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW069181	0.40	1.00	0.76	1
218833_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016653	0.60	1.00	0.82	1
225665_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225662_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238613_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555259_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222757_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223519_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218833_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ZAK for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCAGTAACCC

SOURCE GeneReport for Unigene cluster: Hs.444451
UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
Tissue specificity: Ubiquitously expressed. Isoform 2 is the predominant form in all tissues
examined, except for liver, in which isoform 1 is more highly expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ZAK gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC478802¹	--	similar to mixed lineage kinase-related kinase MRK-beta more	91.12(n) 92.12(a)	478802 XM_535966.2 XP_535966.2
mouse (Mus musculus)	B230120H23Rik^{1, 5}	2⁵	RIKEN cDNA B230120H23 gene^{1, 5}	87.65(n)¹ 92.24(a)¹	65964¹ NM_023057.2¹ NP_075544.1¹ AB049731⁵ AB049732⁵ (see all 15)
chicken (Gallus gallus)	ZAK¹	--	sterile alpha motif and leucine zipper containing kinase more	75.02(n) 76.58(a)	424149 XM_421996.2 XP_421996.2
zebrafish (Danio rerio)	LOC559247¹	--	similar to Mitogen-activated protein kinase kinase more	63.24(n) 62.94(a)	559247 XM_682568.2 XP_687660.2
tropical clawed frog (Silurana tropicalis)	AL898835.2²	--	--	81.39(n)	AL898835.2

About this table Species with no ortholog for ZAK

ENSEMBL Gene Tree for ZAK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ZAK gene

MAP3K11² KIAA1804² MAP3K9² MAP3K10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/978 NCBI SNPs in ZAK are shown (see all 978 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 354)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2119123^1,2	A,C,F,H,O	173800210(-)	`CTTGTG/TTGCAT`	2	--	int¹ ng3¹		17	EA NA EU WA	2874
	rs11249^1,2	A,C,F,H,O	173794918(+)	`GACACG/ATAGTA`	2	--	int¹ ut3¹ ese³		13	MN EU EA WA NA	1295
	rs2028382^1,2	A,C,F,H,O	173795993(-)	`TATGAT/GGATGT`	2	--	ut3¹ int¹		10	MN EU EA WA NA	1998
	rs4972399^1,2	A,C,F,H	173799446(+)	`GTTTAA/GGTGTT`	2	--	int¹ ut3¹		11	NA EU EA WA	982
	rs7593622^1,2	A,C,F,H	173839059(+)	`GGATGC/TGGCAG`	1	R/W	mis¹ ese³		11	EU EA WA NA	980
	rs1123669^1,2	C,F,H,O	173841054(+)	`CAGTGC/TTCTGT`	1	--	ng3¹		13	NA EA EU WA	860
	rs10497401^1,2	A,C,F,H	173797852(-)	`TGTACA/CATATC`	2	--	int¹ ut3¹		17	NS EA NA EU WA	1154
	rs11887008^1,2	A,C,F,H	173799334(+)	`CTTATC/TGCAGC`	2	--	ut3¹ int¹ ese³		8	EU EA WA NA	634
	rs6758025^1,2	C,F,H	173782758(+)	`TGACAC/TGAGCC`	2	T/M	mis¹ ese³		9	EU EA WA NA	904
	rs8446^1,2	C,F,H	173798788(+)	`AAAAAC/TGGTTT`	2	--	int¹ ut3¹		11	MN EU EA WA NA	1112

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HapMap Linkage Disequilibrium images for ZAK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609479

2 Novoseek disease relationships for ZAK gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypertrophy	47.85	3	15485649 (1), 19184368 (1), 15465036 (1)
cardiac hypertrophy	44.91	2	11549352 (1), 15465036 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

Improved Imaging for Identifying Breast Cancer in Overweight Women

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/32 PubMed articles for ZAK gene (see all 32 ):

MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. (PubMed id 11836244)^{1, 3, 4} Gross E.A.... Ruggieri R. (2002)
Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. (PubMed id 11549352)^{1, 3, 4} Bloem L.J.... Wang X. (2001)
Identification and characterization of a novel MAP kinase kinase kinase, MLTK. (PubMed id 11042189)^{1, 3, 4} Gotoh I.... Nishida E. (2001)
Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. (PubMed id 10924358)^{1, 3, 4} Liu T.-C.... Yang J.-J. (2000)
Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. (PubMed id 12761180)^{1, 3, 4} Takahashi M.... Ono Y. (2003)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. (PubMed id 15684425)^{3, 4} Choi H.S.... Dong Z. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. (PubMed id 15172994)^{3, 4} Cho Y.-Y.... Dong Z. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 51776

AceView: ZAK

Ensembl:ENSG00000091436

euGenes: HUgn51776

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZAK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ZAK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZAK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ZAK Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for ZAK

Summaries
for ZAK

Genomic Location
for ZAK

Proteins
for ZAK

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Families
for ZAK

Gene Function
for ZAK

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZAK (Gene Symbol)
AZK
EC 2.7.11.25
HCCS-4
MLK7
MLT
MLTK
MRK
mlklak
Cervical cancer suppressor gene 4 protein
Leucine zipper- and sterile alpha motif-containing kinase
MLK-like mitogen-activated protein triple kinase
MLK-related kinase
Mixed lineage kinase-related kinase
Sterile alpha motif- and leucine zipper-containing kinase AZK
mitogen-activated protein kinase kinase kinase MLT
mixed lineage kinase 7
mixed lineage kinase with a leucine zipper and a sterile alpha motif
mixed lineage kinase-related kinase MRK-beta
sterile alpha motif and leucine zipper containing kinase AZK

ZAK Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor ZAK

Summariesfor ZAK

Genomic Locationfor ZAK

Proteinsfor ZAK

Protein Domains/Familiesfor ZAK

Gene Functionfor ZAK

Pathways & Interactionsfor ZAK

Drugs & Compoundsfor ZAK

Transcriptsfor ZAK

Expression for ZAK

Orthologsfor ZAK

Paralogsfor ZAK

SNPs/Variantsfor ZAK

Disorders & Mutationsfor ZAK

Medical Newsfor ZAK

Publicationsfor ZAK

Search for ZAK

Genome Databases showing ZAK

Other Databases showing ZAK

Specialized Databases showing ZAK

Licensable Technologiesfor ZAK

Servicesfor ZAK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZAK

Summaries
for ZAK

Genomic Location
for ZAK

Proteins
for ZAK

Protein Domains/
Families
for ZAK

Gene Function
for ZAK

Pathways & Interactions
for ZAK

Drugs & Compounds
for ZAK

Transcripts
for ZAK

Expression
for ZAK

Orthologs
for ZAK

Paralogs
for ZAK

SNPs/Variants
for ZAK

Disorders & Mutations
for ZAK

Medical News
for ZAK

Publications
for ZAK

Licensable Technologies
for ZAK

Services
for ZAK