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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZAK Gene

protein-coding   GIFtS: 53
GCID: GC02P173940

ZAK
 Explore 4 diseases affiliated with
ZAK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ZAK    

Aliases
for ZAK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MRK2 3 5     Mixed Lineage Kinase-Related Kinase MRK-Beta2
Human Cervical Cancer Suppressor Gene 4 Protein2 3     Mlklak1
HCCS-42 3     Pk1
MLK-Like Mitogen-Activated Protein Triple Kinase2 3     Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK2
MLTK2 5     EC 2.7.11.253
AZK2     Leucine Zipper- And Sterile Alpha Motif-Containing Kinase3
MLK72     Mixed Lineage Kinase-Related Kinase3
MLT2     MLK-Related Kinase3
Mitogen-Activated Protein Kinase Kinase Kinase MLT2     Sterile Alpha Motif- And Leucine Zipper-Containing Kinase AZK3
Mixed Lineage Kinase 72     EC 2.7.118
Mixed Lineage Kinase With A Leucine Zipper And A Sterile Alpha Motif2     

External Ids:    Entrez Gene: 517762   Ensembl: ENSG000000914367   OMIM: 6094795   UniProtKB: Q9NYL23   

Export aliases for ZAK gene to outside databases

Previous GC identifers: GC02P171993 GC02P172601 GC02P173904 GC02P174143 GC02P173766 GC02P173648 GC02P165819


Summaries
for ZAK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ZAK:
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal
kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding
protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to
cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein
also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been
characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38
pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2.
Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in
neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at
'Ser-28'

Gene Wiki entry for ZAK


Genomic Views
for ZAK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZAK gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   CUTL1   E2F-2   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ZAK promoter sequence
   Search SABiosciences Chromatin IP Primers for ZAK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZAK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q31.1   

ZAK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZAK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P173940:  view genomic region     (about GC identifiers)

Start:
 173,940,163 bp from pter      End:
 174,132,738 bp from pter
Size:
 192,576 bases      Orientation:
 plus strand

Proteins
for ZAK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase MLT  
Size: 800 amino acids; 91155 Da
Cofactor: Magnesium
Subunit: Homodimer. Interacts with PKN1 and ZNF33A
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation
Sequence caution: Sequence=BAD92211.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KPG2 Q53SX1 Q580W8 Q59GY5 Q86YW8 Q9HCC4 Q9HCC5 Q9HDD2 Q9NYE9
Alternative splicing: 3 isoforms:  Q9NYL2-1   Q9NYL2-2   Q9NYL2-3   (Contains a phosphoserine at position 339. Contains a phosphoserine at position 429. Contains a phosphoserine at position 434. Contains a phosphoserine at position 454)

Explore the universe of human proteins at neXtProt for ZAK: NX_Q9NYL2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYL2

    • 3 DME Specific Peptides for ZAK (Q9NYL2)
     VIHRDLK  LKICDFG  WMAPEVI 

    ZAK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_057737.2  NP_598407.1  

    ENSEMBL proteins: 
     ENSP00000387259   ENSP00000340257   ENSP00000364361   ENSP00000411923   ENSP00000439414  
     ENSP00000399787  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): ZAK
    OriGene Protein Over-expression Lysate (see all 3): ZAK
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    Novus Biologicals ZAK Proteins
    Novus Biologicals ZAK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZAK

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ISS--


    ZAK for ontologies           About GeneDecksing



    ZAK Antibody Products: 
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    ThermoFisher Antibodies for ZAK

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    Uscn ELISAs and CLIAs for ZAK

    Protein Domains /
    Families
    for ZAK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ZAK for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021129 SAM_type1
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYL2

    ProtoNet protein and cluster: Q9NYL2

    2 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for ZAK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
    Function: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38
    pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2.
    Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in
    neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at
    'Ser-28'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165

    Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.251

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZAK
    8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate ZAK (see all 96):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-342-3p hsa-miR-550a* hsa-miR-890
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZAK (see all 4)
    OriGene shRNA RFP: ZAK
    OriGene siRNA: ZAK
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZAK (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for ZAK

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAK

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA11836244
    GO:0004674protein serine/threonine kinase activity IDA11836244
    GO:0004709MAP kinase kinase kinase activity IDA11836244
    GO:0005515protein binding IPI12761180
    GO:0005524ATP binding IDA11836244


    ZAK for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for ZAK:
     Decreased substrate adherent c  Increased Salmonella enterica   Increased mitotic index  Reduced beta-catenin activity  
     Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for ZAK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins
    		G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins1.00
    		G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins1.00
    2MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    3Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    4Signaling mediated by p38-gamma and p38-delta
    		Signaling mediated by p38-gamma and p38-delta1.00
    5Tight junction
    		Tight junction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ZAK
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ZAK
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    1 GeneGo (Thomson Reuters) Pathway for ZAK
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

    2 BioSystems Pathways for ZAK 
        MAPK signaling pathway
    Signaling mediated by p38-gamma and p38-delta


    2         Kegg Pathways  (Kegg details for ZAK):
        MAPK signaling pathway
    Tight junction


    ZAK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZAK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/31 Interacting proteins for ZAK (Q9NYL21, 2, 3 ENSP000003643614) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF567Q8N1842, 3, ENSP000003539574MINT-67507 I2D: score=5 STRING: ENSP00000353957
    CCDC69A6NI792, 3, ENSP000003475864STRING: ENSP00000347586 MINT-8277236 I2D: score=2 
    VPS33BQ9H2672, 3, ENSP000003276504MINT-8277389 I2D: score=2 STRING: ENSP00000327650
    CRMP1Q141942, 3MINT-8277247 I2D: score=2 
    DDAH2O958652, 3MINT-8277258 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint IDA15342622
    GO:0000077DNA damage checkpoint IMP11836244
    GO:0000165MAPK cascade ----
    GO:0000186activation of MAPKK activity TAS11836244
    GO:0006468protein phosphorylation IDA11836244


    ZAK for ontologies           About GeneDecksing



    Drugs & Compounds
    for ZAK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZAK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZAK
    3 Novoseek chemical compound relationships for ZAK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 34.3 4 11549352 (1)
    threonine 33.3 1 11549352 (1)
    serine 18.8 1 11549352 (1)

    Search CenterWatch for drugs/clinical trials and news about ZAK / MLTK 

    Transcripts
    for ZAK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ZAK gene (2 alternative transcripts): 
    NM_016653.2  NM_133646.2  

    Unigene Cluster for ZAK:

    Sterile alpha motif and leucine zipper containing kinase AZK
    Hs.444451  [show with all ESTs]
    Unigene Representative Sequence: AF480462
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409176 ENST00000468408 ENST00000338983(uc002uhy.3 uc010zei.2)
    ENST00000476618(uc002uhx.3) ENST00000375213(uc002uhz.3) ENST00000422149
    ENST00000480606 ENST00000539448 ENST00000431503

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZAK
    8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate ZAK (see all 96):
    hsa-miR-26a-2* hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-15a hsa-miR-342-3p hsa-miR-550a* hsa-miR-890
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZAK (see all 4)
    OriGene shRNA RFP: ZAK
    OriGene siRNA: ZAK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZAK
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZAK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZAK

    Additional cDNA sequence: 

    AB030034.1 AB041883.1 AB049733.1 AB049734.1 AB208974.1 AF238255.1 AF251441.1 AF325454.1 
    AF465843.1 AF480461.1 AF480462.1 AK056310.1 AK095825.1 AK096877.1 AK291825.1 AK298634.1 
    AL833180.1 BC001401.2 

    10 DOTS entries:

    DT.423171  DT.452501  DT.87016635  DT.100783996  DT.91811205  DT.100678385  DT.120976575  DT.100028728 
    DT.95167694  DT.99932386 

    24/380 AceView cDNA sequences (see all 380):

    BF508076 CN479035 AW502467 AI468464 R91202 AB049734 AL701472 AA232772 
    BG119452 BM755642 AI276448 AI858232 BU608932 AW516988 AI922069 AI955029 
    AI346235 BC001401 AI096766 BQ775913 AI470677 CD676494 AA307684 AI066646 

    GeneLoc Exon Structure


    Expression
    for ZAK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZAK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGTAACCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ZAK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZAK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZAK

    SOURCE GeneReport for Unigene cluster: Hs.444451

    UniProtKB/Swiss-Prot: MLTK_HUMAN, Q9NYL2
    Tissue specificity: Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for
    liver, in which isoform 1 is more highly expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including ZAK: 
              Tight Junctions in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZAK

    Orthologs
    for ZAK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZAK gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ZAK1 sterile alpha motif and leucine zipper containing kinase more 75.21(n)
    76.67(a)    		   424149  XM_421996.3  XP_421996.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343316.1(1088209-1226024)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL898835.22   -- 81.39(n)    AL898835.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-15i8.31 si:dkey-15i8.3 63.24(n)
    62.94(a)    		   559247  XM_682568.2  XP_687660.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G047006
    AT5G576106
    (see all 7)    		 PB1 domain-containing protein tyrosine kinase
    octicosapeptide/Phox/Bem1p domain-containing prote...
    (see all 7)    		 9(a)
    9(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(1316254-1320919)
    5(23324791-23329347)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)    		 9(a)
    8(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 2(33380337-33387027)
    7(14722116-14730584)


    ENSEMBL Gene Tree for ZAK (if available)
    TreeFam Gene Tree for ZAK (if available) 

    Paralogs
    for ZAK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZAK gene
    MAP3K112  MAP3K122  KIAA18042  RAF12  KSR22  KSR12  MOS2  BRAF2  
    MAP3K102  MAP3K92  ARAF2  MAP3K72  MAP3K7CL2  TNNI3K2  MAP3K132  ILK2  
    18/25 SIMAP similar genes for ZAK using alignment to 2 protein entries:     B4DQ47_HUMAN (see all proteins) (see all similar genes):
    pk    MLTK    SRC    HCK    BLK    TNNI3K
    MAP3K9    FGR    TNIK    BTK kinase deficient isoform 6    NEK5    RAF1
    tec    EGFR    BRAF    MAP4K4    MARK2    NEK11

    ZAK for paralogs           About GeneDecksing



    Genomic Variants
    for ZAK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3238 NCBI SNPs in ZAK are shown (see all 3238)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs797325191,2
    		C,F,--165817912(+) GGCAAT/AGTGGC 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs781781911,2
    		F,--165817986(+) AGCTGG/AAACCT 2 -- us2k11Minor allele frequency- A:0.14WA 118
    rs796533271,2
    		--165818093(+) CAGAAA/GTCAGG 2 -- us2k10--------
    rs751120421,2
    		--165818677(+) CCAATT/CTCTGT 2 -- us2k11Minor allele frequency- C:0.01NA 120
    rs801109641,2
    		C,--165819033(+) CCATTC/TCCTAC 2 -- us2k12Minor allele frequency- T:0.33WA CSA 3
    rs784432541,2
    		C,F,--165819348(+) GCCCAC/GCTCCA 2 -- us2k11Minor allele frequency- G:0.02NA 120
    rs775528921,2
    		--165819352(+) ACCTCC/TACCTT 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs730216191,2
    		C,--165820055(+) GGTCAG/AGCTGG 2 -- int14Minor allele frequency- A:0.26NA WA EA 244
    rs750599061,2
    		--165820348(+) TTGGCA/GCCTGG 2 -- int10--------
    rs1114713131,2
    		C,--165820393(+) CGCGGA/TCCCGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZAK (173940163 - 174132738 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZAK: --

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    Disorders / Diseases
    for ZAK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ZAK for disorders           About GeneDecksing

    OMIM gene information: 609479    OMIM disorders: --

    4 diseases for ZAK:    About MalaCards
    cervical cancer    cervicitis    giant cell tumor    lung cancer

    2 Novoseek disease relationships for ZAK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 47 3 15485649 (1), 19184368 (1), 15465036 (1)
    cardiac hypertrophy 43.9 2 11549352 (1), 15465036 (1)

    Human Genome Epidemiology (HuGE) Navigator: ZAK (28 documents)

    Export disorders for ZAK gene to outside databases

    Publications
    for ZAK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZAK gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with ZAK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. (PubMed id 11836244)1, 2, 9 Gross E.A.... Ruggieri R. (2002)
    2. Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. (PubMed id 11549352)1, 2, 9 Bloem L.J.... Wang X. (2001)
    3. Identification and characterization of a novel MAP kinase kinase kinase, MLTK. (PubMed id 11042189)1, 2, 9 Gotoh I.... Nishida E. (2001)
    4. Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. (PubMed id 10924358)1, 2, 9 Liu T.-C.... Yang J.-J. (2000)
    5. Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. (PubMed id 12761180)1, 2, 9 Takahashi M.... Ono Y. (2003)
    6. Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. (PubMed id 15684425)1, 2 Choi H.S.... Dong Z. (2005)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    8. The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway. (PubMed id 15342622)1, 2 Tosti E.... Ruggieri R. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development. (PubMed id 15172994)1, 2 Cho Y.-Y.... Dong Z. (2004)

    External Searches for ZAK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ZAK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51776 AceView: ZAK Ensembl:ENSG00000091436 euGenes: HUgn51776 Kegg: 51776

    Other Databases showing ZAK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ZAK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for ZAK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ZAK gene:
    Search GeneIP for patents involving ZAK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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