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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZADH2 Gene

protein-coding   GIFtS: 47
GCID: GC18M072907

Zinc Binding Alcohol Dehydrogenase Domain Containing 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Binding Alcohol Dehydrogenase Domain Containing 21 2
Zinc-Binding Alcohol Dehydrogenase Domain-Containing Protein 22
EC 1.-.-.-3

External Ids:    HGNC: 286971   Entrez Gene: 2842732   Ensembl: ENSG000001800117   UniProtKB: Q8N4Q03   

Export aliases for ZADH2 gene to outside databases

Previous GC identifers: GC18M071038 GC18M071041 GC18M069594


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZADH2 Gene: 
ZADH2 (zinc binding alcohol dehydrogenase domain containing 2) is a protein-coding gene. Diseases associated with ZADH2 include alcoholism. GO annotations related to this gene include oxidoreductase activity and molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_025028.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZADH2 gene promoter:
         GR   Sox5   GATA-3   GR-beta   FOXD3   LCR-F1   GATA-2   GATA-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZADH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZADH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZADH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

ZADH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZADH2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M072907:  view genomic region     (about GC identifiers)

Start:
72,907,063 bp from pter      End:
72,921,303 bp from pter
Size:
14,241 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0 (See protein sequence)
Recommended Name: Zinc-binding alcohol dehydrogenase domain-containing protein 2  
Size: 377 amino acids; 40140 Da
Subcellular location: Peroxisome (By similarity)
4 PDB 3D structures from and Proteopedia for ZADH2:
2C0C (3D)        2WEK (3D)        2X1H (3D)        2X7H (3D)    
Secondary accessions: A8KA15

Explore the universe of human proteins at neXtProt for ZADH2: NX_Q8N4Q0

Explore proteomics data for ZADH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N4Q0

  • ZADH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZADH2 Protein Expression
    REFSEQ proteins: NP_787103.1  
    ENSEMBL proteins: 
     ENSP00000323678   ENSP00000440111   ENSP00000463106   ENSP00000463844  

    Human Recombinant Protein Products for ZADH2: 
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    Novus Biologicals ZADH2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZADH2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome ISS--

    ZADH2 for ontologies           About GeneDecksing



    ZADH2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for ZADH2 
    Cloud-Clone Corp. CLIAs for ZADH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR016040 NAD(P)-bd_dom
     IPR013154 ADH_GroES-like
     IPR002364 Quin_OxRdtase/zeta-crystal_CS

    Graphical View of Domain Structure for InterPro Entry Q8N4Q0

    ProtoNet protein and cluster: Q8N4Q0

    1 Blocks protein domain: IPB002364 Quinone oxidoreductase/zeta-crystallin

    UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    ZADH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    ZADH2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZADH2:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZADH2 
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    SwitchGear 3'UTR luciferase reporter plasmidZADH2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZADH2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZADH2 (ENSP000003236784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0055114oxidation-reduction process ----

    ZADH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZADH2

    7 HMDB Compounds for ZADH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--

    Search CenterWatch for drugs/clinical trials and news about ZADH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZADH2 gene: 
    NM_175907.4  

    Unigene Cluster for ZADH2:

    Zinc binding alcohol dehydrogenase domain containing 2
    Hs.465433  [show with all ESTs]
    Unigene Representative Sequence: NM_175907
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322342(uc010dqv.3 uc002llx.3) ENST00000537114 ENST00000582437
    ENST00000581620
    miRNA
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    hsa-miR-579 hsa-miR-26a-2* hsa-miR-3938 hsa-miR-520f hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidZADH2 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZADH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZADH2

    Additional mRNA sequence: 

    AK292880.1 AK302801.1 BC010734.1 BC018081.1 BC033780.1 BC064618.1 BC075853.1 BC078661.1 
    BX647730.1 

    8 DOTS entries:

    DT.95274619  DT.443614  DT.306220  DT.100764180  DT.306710  DT.100799321  DT.121087709  DT.91916927 

    24/170 AceView cDNA sequences (see all 170):

    CR610486 CK819717 C05192 N94610 AI698115 BE671522 AA442520 N38946 
    CA443759 BM975841 AW134753 Z39720 CA441598 AI608774 CA429137 BU838591 
    AW297357 BC064618 AI802990 AI266263 BG576904 CD107001 BM682176 BX647730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZADH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAAGAGGG
    ZADH2 Expression
    About this image


    See ZADH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZADH2

    SOURCE GeneReport for Unigene cluster: Hs.465433
        SABiosciences Custom PCR Arrays for ZADH2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZADH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZADH2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zadh21 , 5 zinc binding alcohol dehydrogenase, domain containing more1, 5 84.53(n)1
    88.06(a)1
      18 (57.53 cM)5
    2257911  NM_146090.51  NP_666202.21 
     840881585 
    chicken
    (Gallus gallus)
    Aves ZADH21 zinc binding alcohol dehydrogenase domain containing more 79.72(n)
    81.55(a)
      421010  XM_419096.3  XP_419096.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZADH26
    Uncharacterized protein
    73(a)
    1 ↔ 1
    4(49787391-49798579)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.141872 Xenopus laevis transcribed sequence with weak similarity more 76.38(n)    CB198142.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZTA16
    NADPH-dependent quinone reductase, GFP-tagged prot...
    26(a)
    1 → many
    II(330507-331511)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NQR1 ARP protein 52.63(n)
    47.27(a)
      841391  NM_103855.4  NP_175390.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g04598001 hypothetical protein 49.51(n)
    46.76(a)
      4347279  NM_001069918.1  NP_001063383.1 


    ENSEMBL Gene Tree for ZADH2 (if available)
    TreeFam Gene Tree for ZADH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZADH2 gene
    2 SIMAP similar genes for ZADH2 using alignment to 5 protein entries:     ZADH2_HUMAN (see all proteins):
    PTGR1    VAT1

    ZADH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/306 SNPs in ZADH2 are shown (see all 306)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423169851,2
    C--72908866(+) GAAAC-/AATT  
            
    AAACA
    1 -- ds50010--------
    rs101639111,2
    C,F--72909097(+) TGATGC/TTATAA 1 -- ds50012Minor allele frequency- T:0.08WA NA 238
    rs10475281,2
    F--72909134(-) TTTTTA/C/TTTTTT 1 -- ds50012NA 4
    rs1807008801,2
    --72909165(+) TTTGAG/TAGCAA 1 -- ds50010--------
    rs1510787101,2
    --72909280(+) TTCTCC/TATGAT 1 -- ut310--------
    rs11295621,2
    C,H--72909321(-) GATGTC/GTTGAA 1 -- ut316Minor allele frequency- G:0.48NA EA 248
    rs1413706091,2
    C--72909348(+) TATATA/GCACCT 1 -- ut310--------
    rs1446718111,2
    --72909365(+) TACCCA/GTAAGA 1 -- ut310--------
    rs1386095171,2
    C--72909422(+) CAACCA/GTATTG 1 -- ut310--------
    rs1415114551,2
    --72909491(+) CCAACC/TGTACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZADH2 (72907063 - 72921303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZADH2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833695CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZADH2:    About MalaCards
    alcoholism    


    ZADH2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZADH2
    Human Genome Epidemiology (HuGE) Navigator: ZADH2 (2 documents)

    Export disorders for ZADH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZADH2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ZADH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid beta-oxidation in peroxisomal matrix. (PubMed id 22002062)1 Okumoto K.... Fujiki Y. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284273 HGNC: 28697 AceView: ZADH2 Ensembl:ENSG00000180011 euGenes: HUgn284273
    ECgene: ZADH2 H-InvDB: ZADH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZADH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZADH2 gene:
    Search GeneIP for patents involving ZADH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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