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ZADH2 Gene

protein-coding GIFtS: 43

GC18M071041

zinc binding alcohol dehydrogenase domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 1.-.-.- ^³
MGC45594 ^¹, ²

Descriptions
zinc binding alcohol dehydrogenase domain containing 2 ^²

External Ids
HGNC: 28697¹
Entrez Gene: 284273²
UniProtKB: Q8N4Q0³
Ensembl: ENSG00000180011⁷

Search outside databases for aliases for ZADH2 gene

Previous GC identifer: GC18M071038

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ZADH2 gene

Entrez Gene cytogenetic band: 18q22.3 Ensembl cytogenetic band: 18q22.3 HGNC cytogenetic band: 18q22.3

ZADH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M071041: (about GC identifiers)

Start:	71,039,464 bp from pter
End:	71,050,105 bp from pter
Size:	10,642 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_025004.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0 (See protein sequence)

Recommended Name: Zinc-binding alcohol dehydrogenase domain-containing protein 2

Size: 377 amino acids; 40140 Da

PDB structures from and Proteopedia :

2C0C (3D)

REFSEQ proteins: NP_787103.1

ENSEMBL proteins:

ENSP00000323678

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ZADH2)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: ZADH2

Antibodies for ZADH2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ZADH2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ZADH2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ZADH2

Assays for ZADH2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8N4Q0

ProtoNet protein and cluster: Q8N4Q0

1 Blocks protein family: IPB002364 Quinone oxidoreductase/zeta-crystallin

UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase

subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZADH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZADH2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC033780

Applied Biosystems Silencer® siRNAs for ZADH2

Sigma-Aldrich siRNA and siRNA Panels for ZADH2

Sigma-Aldrich shRNA for ZADH2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ZADH2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_175907
Myc/DDK tagged cDNA clone in CMV expression vector: NM_175907
untagged cDNA clones in CMV expression vector (see all 2): BC033780

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_175907

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ZADH2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ZADH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ZADH2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC033780

Sigma-Aldrich siRNA and siRNA Panels for ZADH2

Sigma-Aldrich shRNA for ZADH2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_175907

REFSEQ mRNAs for ZADH2 gene:

NM_175907.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_175907

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_175907
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_175907
                                 untagged cDNA clones in CMV expression vector (see all 2): BC033780

Additional cDNA sequence:

AK292880.1 AK302801.1 BC010734.1 BC018081.1 BC033780.1 BC064618.1 BC075853.1 BC078661.1

BX647730.1 CR610486.1

8 DOTS entries:

DT.95274619 DT.443614 DT.306220 DT.100764180 DT.306710 DT.121087709 DT.100799321 DT.91916927

24/170 AceView cDNA sequences (see all 170 ):

Z39720 AI698106 AI698115 AA780047 CA443759 BC064618 AI608774 AI802990

N38946 CA441598 C05192 AI266263 N94610 BM682176 BG576904 CA429137

AA442520 BM975841 CR610486 AW134753 BM129804 BQ940777 BC010734 BE671522

highest scoring ESTs for ZADH2:

AI633993 AL704805 BC018081 BC033780 BG707600 BG707948 BG740120 BI758142 BM802850 BQ062722

Unigene Cluster for ZADH2:

Zinc binding alcohol dehydrogenase domain containing 2

Hs.465433 [show with all ESTs]

Unigene Representative Sequence: NM_175907

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000322342

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ZADH2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ZADH2

¹ / ² / ³

13 probe-sets matching ZADH2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
61776_at²^{, 3}	U95-C	1	1.00	1.00	0.63	1.27	AI633993	0.80	1.00	0.91	1
59291_at²^{, 3}	U95-C	1	1.00	1.00	0.69	1.27	U55988	0.80	1.00	0.91	1
45664_at²^{, 3}	U95-B	1	1.00	1.00	0.81	0.67	W27343	0.80	1.00	0.91	1
64375_at²^{, 3}	U95-C	1	0.69	1.00	0.74	0.80	W03531	0.60	1.00	0.82	1
227978_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF591611	0.60	1.00	0.82	1
227977_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF591611	0.60	1.00	0.82	1
227049_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N21127	0.40	1.00	0.76	1
234977_at²^{, 3}	U133-B	1	0.82	1.00	--	--	BG168924	0.60	1.00	0.82	1
1554239_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227978_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227977_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227049_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234977_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks ZADH2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.465433

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ZADH2 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ZADH2¹	--	zinc binding alcohol dehydrogenase domain containing more	89.83(n) 90.19(a)	476162 XM_533369.2 XP_533369.1
chimpanzee (Pan troglodytes)	ZADH2¹	--	zinc binding alcohol dehydrogenase domain containing more	99.2(n) 99.47(a)	455477 XM_001138011.1 XP_001138011.1
cow (Bos taurus)	ZADH2¹	--	zinc binding alcohol dehydrogenase domain containing more	85.23(n) 87.53(a)	532505 NM_001075964.1 NP_001069432.1
rat (Rattus norvegicus)	Zadh2¹	--	zinc binding alcohol dehydrogenase, domain containing more	84.44(n) 88.86(a)	291403 XM_214526.4 XP_214526.2
mouse (Mus musculus)	Zadh2^{1, 5}	18⁵	zinc binding alcohol dehydrogenase, domain containing more^{1, 5}	84.44(n)¹ 88.06(a)¹	225791¹ NM_146090.3¹ NP_666202.2¹ AI850683⁵ AK047559⁵ (see all 13)

About this table Species with no ortholog for ZADH2

ENSEMBL Gene Tree for ZADH2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ZADH2 gene

PTGR1² PTGR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/49 NCBI SNPs in ZADH2 are shown (see all 49 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 67)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs632157^1,2	A,C,F,H	71040536(-)	`CCACAC/TGGAAA`	1	--	ut3¹ ese³		5	MN EU EA WA	602
	rs2292233^1,2	C,F,H,O	71039982(-)	`ATTCCG/TCCCAT`	1	--	ut3¹ ese³		8	EA NA EU WA	2034
	rs9240^1,2	A,C,F,H	71039675(-)	`GCTTAA/GGGTCA`	1	--	ut3¹ ese³		13	MN EA NA EU WA	2666
	rs658974^1,2	A,C,F,H	71039209(-)	`ACAACG/ACAGAC`	1	--	ng5¹		9	MN EU EA WA	1020
	rs17056651^1,2	C,F,H	71040667(+)	`AGGCCG/ACTACC`	1	--	ut3¹ ese³		11	NA EU EA WA	958
	rs17181586^1,2	C,F,H	71041377(+)	`AGTTCG/AAACGC`	1	--	ut3¹		11	NA EU EA WA	978
	rs1132845^1,2	C,F,H	71041457(-)	`GGTACG/AGTATG`	1	--	ut3¹ ese³		20	MN NA EU EA WA	1942
	rs17056661^1,2	C,F,H	71042525(+)	`TCACAC/AACATC`	1	F/C	mis¹ ese³		11	NA EU EA WA	978
--	rs17056648^1,2	F,H	71039765(+)	`TGACAG/ATTGCC`	1	--	ut3¹		6	NA EU EA	438
	rs2581647^1,2	H	71040950(+)	`TTCCTT/CGCTCC`	1	--	ut3¹		4	EU EA WA	400

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HapMap Linkage Disequilibrium images for ZADH2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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2 PubMed articles for ZADH2 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 284273	HGNC: 28697	AceView: ZADH2	Ensembl:ENSG00000180011	euGenes: HUgn284273
ECgene: ZADH2	H-InvDB: ZADH2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ZADH2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ZADH2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ZADH2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ZADH2		Antibodies for ZADH2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ZADH2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for ZADH2

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ZADH2 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for ZADH2

Summaries
for ZADH2

Genomic Location
for ZADH2

Proteins
for ZADH2

Protein Domains/
Families
for ZADH2

Gene Function
for ZADH2

Pathways & Interactions
for ZADH2

Drugs & Compounds
for ZADH2

Transcripts
for ZADH2

Expression
for ZADH2

Orthologs
for ZADH2

Paralogs
for ZADH2

SNPs/Variants
for ZADH2

Disorders & Mutations
for ZADH2

Medical News
for ZADH2

Publications
for ZADH2

Search for ZADH2

Genome Databases showing ZADH2

Other Databases showing ZADH2

Specialized Databases showing ZADH2

Licensable Technologies
for ZADH2

Services
for ZADH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ZADH2 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor ZADH2

Summariesfor ZADH2

Genomic Locationfor ZADH2

Proteinsfor ZADH2

Protein Domains/Familiesfor ZADH2

Gene Functionfor ZADH2

Pathways & Interactionsfor ZADH2

Drugs & Compoundsfor ZADH2

Transcriptsfor ZADH2

Expression for ZADH2

Orthologsfor ZADH2

Paralogsfor ZADH2

SNPs/Variantsfor ZADH2

Disorders & Mutationsfor ZADH2

Medical Newsfor ZADH2

Publicationsfor ZADH2

Search for ZADH2

Genome Databases showing ZADH2

Other Databases showing ZADH2

Specialized Databases showing ZADH2

Licensable Technologiesfor ZADH2

Servicesfor ZADH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ZADH2

Summaries
for ZADH2

Genomic Location
for ZADH2

Proteins
for ZADH2

Protein Domains/
Families
for ZADH2

Gene Function
for ZADH2

Pathways & Interactions
for ZADH2

Drugs & Compounds
for ZADH2

Transcripts
for ZADH2

Expression
for ZADH2

Orthologs
for ZADH2

Paralogs
for ZADH2

SNPs/Variants
for ZADH2

Disorders & Mutations
for ZADH2

Medical News
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Publications
for ZADH2

Licensable Technologies
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