ZADH2 Gene
protein-coding GIFtS: 45
GCID: GC18M072907
|
|
zinc binding alcohol dehydrogenase domain containing 2
| |
Aliases
for ZADH2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Binding Alcohol Dehydrogenase Domain Containing 21 2 | | MGC455941 | | Zinc-Binding Alcohol Dehydrogenase Domain-Containing Protein 22 | | EC 1.-.-.-3 |
Export aliases for ZADH2 gene to outside databasesPrevious GC identifers: GC18M071038 GC18M071041 GC18M069594 |
Summaries
for ZADH2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ZADH2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_025028.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZADH2 gene promoter:
GR Sox5 GATA-3 GR-beta FOXD3 LCR-F1 GATA-2 GATA-1 AREB6 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZADH2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZADH2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q22.3 Ensembl cytogenetic band: 18q22.3 HGNC cytogenetic band: 18q22.3ZADH2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M072907: view genomic region
(about GC identifiers)
Start:
|
72,907,063 bp from pter |
End:
|
72,921,303 bp from pter |
Size:
|
14,241 bases |
Orientation:
|
minus strand |
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Proteins
for ZADH2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0 (See
protein sequence)Recommended Name: Zinc-binding alcohol dehydrogenase domain-containing protein 2 Size: 377 amino acids; 40140 Da
Subcellular location: Peroxisome (By similarity)
4 PDB 3D structures from  and Proteopedia  for ZADH2:2C0C (3D)
2WEK (3D)
2X1H (3D)
2X7H (3D)
Secondary accessions: A8KA15Explore the universe of human proteins at neXtProt for ZADH2: NX_Q8N4Q0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4Q0
ZADH2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_787103.1
ENSEMBL proteins: ENSP00000323678 ENSP00000440111 ENSP00000463106 ENSP00000463844
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZADH2 for ontologies About GeneDecksing
ZADH2 Antibody Products:
Assay Products for ZADH2: |
Protein
Domains /
Families
for ZADH2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZADH2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8N4Q0ProtoNet protein and cluster: Q8N4Q0 1 Blocks protein family: IPB002364 Quinone oxidoreductase/zeta-crystallin
UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily |
Function
for ZADH2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 1.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZADH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZADH2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZADH2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZADH2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ZADH2:
|
Pathways & Interactions
for ZADH2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZADH2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZADH2 (ENSP000003236784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
ZADH2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZADH2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZADH2
7 HMDB Compounds for ZADH2 About this table
Search CenterWatch for drugs/clinical trials and news about ZADH2
|
Transcripts
for ZADH2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZADH2 gene: NM_175907.4 Unigene Cluster for ZADH2: Zinc binding alcohol dehydrogenase domain containing 2 Hs.465433 [show with all ESTs]Unigene Representative Sequence: NM_1759074 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000322342(uc010dqv.3 uc002llx.3) ENST00000537114 ENST00000582437
ENST00000581620
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZADH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZADH2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZADH2 (NM_175907) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZADH2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZADH2 |
Additional cDNA sequence: AK292880.1 AK302801.1 BC010734.1 BC018081.1 BC033780.1 BC064618.1 BC075853.1 BC078661.1 BX647730.1 8 DOTS entries: DT.95274619 DT.443614 DT.306220 DT.100764180 DT.306710 DT.100799321 DT.121087709 DT.91916927 24/170 AceView cDNA sequences (see all 170): BG576904 BC064618 AI802990 BC010734 AI698115 CA429137 C05192 CA441598 BM682176 CD107001 AA780047 BQ940777 AW134753 Z39720 N94610 AI266263 BX647730 N38946 AA442520 CA429611 CK819717 CA443759 BE671522 BC075853
GeneLoc Exon Structure
|
Expression
for ZADH2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZADH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTAAGAGGG
About this image
See ZADH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZADH2
SOURCE GeneReport for Unigene cluster: Hs.465433
SABiosciences Custom PCR Arrays for ZADH2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZADH2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZADH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZADH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZADH2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZADH2 |
Orthologs
for ZADH2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ZADH2 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZADH21 |
zinc binding alcohol dehydrogenase domain containing more |
79.72(n)
81.55(a) |
|
421010 XM_419096.3 XP_419096.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ZADH26 |
-- |
77(a) |
1 ↔ 1 |
4(49787391-49798513) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.141872 |
Xenopus laevis transcribed sequence with weak similarity more |
76.38(n) |
|
CB198142.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NQR1 |
ARP protein |
52.63(n)
47.27(a) |
|
841391 NM_103855.4 NP_175390.2 |
rice
(Oryza sativa) |
Liliopsida |
Os09g04598001 |
hypothetical protein |
49.51(n)
46.76(a) |
|
4347279 NM_001069918.1 NP_001063383.1 |
ENSEMBL Gene Tree for ZADH2 (if available)
TreeFam Gene Tree for ZADH2 (if available) |
Paralogs
for ZADH2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZADH2 gene
- VAT12 VAT1L2 CRYZ2 TP53I32
2 SIMAP similar genes for ZADH2 using alignment to 5 protein entries: ZADH2_HUMAN (see all proteins):PTGR1 VAT1
ZADH2 for paralogs About GeneDecksing
|
Genomic Variants
for ZADH2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZADH2 (72907063 - 72921303 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZADH2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZADH2 |
|
Disorders
/ Diseases
for ZADH2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZADH2 for disorders About GeneDecksing
2  diseases for ZADH2: About MalaCardsalcoholism nephropathy
Human Genome Epidemiology (HuGE) Navigator: ZADH2 (2 documents)
Export disorders for ZADH2 gene to outside databases
|
Publications
for ZADH2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZADH2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ZADH2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Genetic analysis of diabetic nephropathy on chromosom e 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1 McDonough C.W....Bowden D.W. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for ZADH2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZADH2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZADH2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZADH2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZADH2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZADH2 gene:
Search GeneIP for patents involving ZADH2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZADH2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |
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| |  |  |  |  | | | | |
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 | | | ZADH2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZADH2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZADH2 |
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