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Aliases for ZADH2 Gene

Aliases for ZADH2 Gene

  • Zinc Binding Alcohol Dehydrogenase Domain Containing 2 2 3 5
  • Zinc-Binding Alcohol Dehydrogenase Domain-Containing Protein 2 3 4
  • PRG-3 3 4
  • Prostaglandin Reductase 3 3
  • EC 1.3.1.48 4
  • PTGR3 4

External Ids for ZADH2 Gene

Previous GeneCards Identifiers for ZADH2 Gene

  • GC18M071038
  • GC18M071041
  • GC18M072907
  • GC18M069594

Summaries for ZADH2 Gene

GeneCards Summary for ZADH2 Gene

ZADH2 (Zinc Binding Alcohol Dehydrogenase Domain Containing 2) is a Protein Coding gene. Diseases associated with ZADH2 include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment. GO annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups.

UniProtKB/Swiss-Prot for ZADH2 Gene

  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZADH2 Gene

Genomics for ZADH2 Gene

Regulatory Elements for ZADH2 Gene

Enhancers for ZADH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G075199 2.9 FANTOM5 Ensembl ENCODE dbSUPER 43.1 -1.6 -1600 22.1 HDGF PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A FEZF1 YY1 ZNF143 ZADH2 ZNF407 TSHZ1 GC18P075214
GH18G075267 1.7 Ensembl 12 -58.5 -58534 0.6 PKNOX1 JUN MAFG EP300 ZNF316 MAFF GATA2 POLR2A PBX2 FOS TSHZ1 ZADH2 GC18M075233 ENSG00000276993
GH18G075245 1.3 Ensembl ENCODE dbSUPER 12 -39.1 -39112 6.0 ZSCAN18 IRF2 ZSCAN4 YY1 ZFHX2 GLIS2 ZBTB48 EGR2 ZNF202 NR2F1 ZADH2 TSHZ1 GC18M075233 ENSG00000276993
GH18G075276 0.6 Ensembl ENCODE 11.4 -68.0 -67988 2.1 ZNF266 ZADH2 TSHZ1 CNDP2 GC18M075233 ENSG00000276993
GH18G075280 0.5 ENCODE 11.6 -71.4 -71431 0.8 GATA2 JUN FOS NR2F2 TSHZ1 ZADH2 GC18M075233 ENSG00000276993
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZADH2 on UCSC Golden Path with GeneCards custom track

Promoters for ZADH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105055 -552 5401 PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A FEZF1 YY1 ZNF143 ZNF207

Genomic Location for ZADH2 Gene

Chromosome:
18
Start:
75,195,108 bp from pter
End:
75,209,348 bp from pter
Size:
14,241 bases
Orientation:
Minus strand

Genomic View for ZADH2 Gene

Genes around ZADH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZADH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZADH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZADH2 Gene

Proteins for ZADH2 Gene

  • Protein details for ZADH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4Q0-PTGR3_HUMAN
    Recommended name:
    Prostaglandin reductase 3
    Protein Accession:
    Q8N4Q0
    Secondary Accessions:
    • A8KA15
    • B4DZ91

    Protein attributes for ZADH2 Gene

    Size:
    377 amino acids
    Molecular mass:
    40140 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZADH2 Gene

    Alternative splice isoforms for ZADH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZADH2 Gene

Post-translational modifications for ZADH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZADH2 Gene

No data available for DME Specific Peptides for ZADH2 Gene

Domains & Families for ZADH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N4Q0

UniProtKB/Swiss-Prot:

PTGR3_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with ZADH2: view

No data available for Gene Families for ZADH2 Gene

Function for ZADH2 Gene

Molecular function for ZADH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

Enzyme Numbers (IUBMB) for ZADH2 Gene

Gene Ontology (GO) - Molecular Function for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0036132 13-prostaglandin reductase activity ISS --
GO:0047522 15-oxoprostaglandin 13-oxidase activity IEA --
genes like me logo Genes that share ontologies with ZADH2: view
genes like me logo Genes that share phenotypes with ZADH2: view

Animal Model Products

CRISPR Products

miRNA for ZADH2 Gene

miRTarBase miRNAs that target ZADH2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ZADH2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZADH2 Gene

Localization for ZADH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZADH2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZADH2 gene
Compartment Confidence
peroxisome 5
mitochondrion 3
cytosol 3
nucleus 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome ISS --
genes like me logo Genes that share ontologies with ZADH2: view

Pathways & Interactions for ZADH2 Gene

SuperPathways for ZADH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IEA --
GO:0008150 biological_process ND --
GO:0045599 negative regulation of fat cell differentiation ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ZADH2: view

No data available for Pathways by source and SIGNOR curated interactions for ZADH2 Gene

Drugs & Compounds for ZADH2 Gene

(1) Drugs for ZADH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved Pharma 0

(5) Additional Compounds for ZADH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Butanol
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
71-36-3
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
Propyl alcohol
  • 1-Hydroxypropane
  • 1-Propanol
  • 1-Propyl alcohol
  • Ethylcarbinol
  • Hydroxypropane
71-23-8
genes like me logo Genes that share compounds with ZADH2: view

Transcripts for ZADH2 Gene

Unigene Clusters for ZADH2 Gene

Zinc binding alcohol dehydrogenase domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ZADH2

Alternative Splicing Database (ASD) splice patterns (SP) for ZADH2 Gene

No ASD Table

Relevant External Links for ZADH2 Gene

GeneLoc Exon Structure for
ZADH2
ECgene alternative splicing isoforms for
ZADH2

Expression for ZADH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZADH2 Gene

Protein differential expression in normal tissues from HIPED for ZADH2 Gene

This gene is overexpressed in Stomach (7.9) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZADH2 Gene



Protein tissue co-expression partners for ZADH2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZADH2 Gene:

ZADH2

SOURCE GeneReport for Unigene cluster for ZADH2 Gene:

Hs.465433
genes like me logo Genes that share expression patterns with ZADH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZADH2 Gene

Orthologs for ZADH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZADH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZADH2 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ZADH2 34 35
  • 89.74 (n)
cow
(Bos Taurus)
Mammalia ZADH2 34 35
  • 85.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZADH2 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zadh2 34 16 35
  • 84.53 (n)
rat
(Rattus norvegicus)
Mammalia Zadh2 34
  • 84.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZADH2 34 35
  • 79.42 (n)
lizard
(Anolis carolinensis)
Reptilia ZADH2 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zadh2 34
  • 73.08 (n)
Str.17735 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14187 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 35
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NQR 34
  • 52.63 (n)
rice
(Oryza sativa)
Liliopsida Os09g0459800 34
  • 49.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2016 34
Species where no ortholog for ZADH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZADH2 Gene

ENSEMBL:
Gene Tree for ZADH2 (if available)
TreeFam:
Gene Tree for ZADH2 (if available)

Paralogs for ZADH2 Gene

(2) SIMAP similar genes for ZADH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZADH2: view

No data available for Paralogs for ZADH2 Gene

Variants for ZADH2 Gene

Sequence variations from dbSNP and Humsavar for ZADH2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs147012982 Likely benign 75,211,154(+) CGCGG(C/G)GCACC upstream-variant-2KB, utr-variant-5-prime
rs181312859 Likely benign 75,211,233(+) TCTCC(A/C)CCCGG upstream-variant-2KB, utr-variant-5-prime
rs369841992 Likely benign 75,211,139(+) CCAAG(-/C)CCCCC upstream-variant-2KB, utr-variant-5-prime
rs569703158 Likely benign 75,211,114(+) AGAAG(C/G)GGCGA upstream-variant-2KB, utr-variant-5-prime
rs75774220 Likely benign 75,211,104(+) TCGCA(C/T)TGGAA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZADH2 Gene

Variant ID Type Subtype PubMed ID
esv3643133 CNV loss 21293372
nsv1072812 CNV deletion 25765185
nsv833695 CNV gain 17160897

Variation tolerance for ZADH2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZADH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZADH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZADH2 Gene

Disorders for ZADH2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZADH2 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ZADH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZADH2

Genetic Association Database (GAD)
ZADH2
Human Genome Epidemiology (HuGE) Navigator
ZADH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZADH2
genes like me logo Genes that share disorders with ZADH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZADH2 Gene

Publications for ZADH2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ZADH2 Gene

  • Addgene plasmids for ZADH2

Sources for ZADH2 Gene

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