Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZADH2 Gene

Aliases for ZADH2 Gene

  • Zinc Binding Alcohol Dehydrogenase Domain Containing 2 2 3 5
  • Zinc-Binding Alcohol Dehydrogenase Domain-Containing Protein 2 3 4
  • PRG-3 3 4
  • Prostaglandin Reductase 3 3
  • EC 1.3.1.48 4
  • PTGR3 4

External Ids for ZADH2 Gene

Previous GeneCards Identifiers for ZADH2 Gene

  • GC18M071038
  • GC18M071041
  • GC18M072907
  • GC18M069594

Summaries for ZADH2 Gene

GeneCards Summary for ZADH2 Gene

ZADH2 (Zinc Binding Alcohol Dehydrogenase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is PTGR2.

UniProtKB/Swiss-Prot for ZADH2 Gene

  • Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

Additional gene information for ZADH2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZADH2 Gene

Genomics for ZADH2 Gene

GeneHancer (GH) Regulatory Elements for ZADH2 Gene

Promoters and enhancers for ZADH2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I075199 Promoter/Enhancer 3.1 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 593.1 -1.5 -1510 22.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 IRF4 YY1 ZNF207 ZADH2 TSHZ1 ZNF407 GC18P075214 PIR49314
GH18I075245 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 -39.1 -39111 6 ZSCAN18 IRF2 ZSCAN4 YY1 ZNF335 ZFHX2 GLIS2 ZBTB48 POLR2A RUNX3 ZNF407 ZADH2 TSHZ1 GC18M075233 ENSG00000276993
GH18I075267 Enhancer 1 UCNEbase Ensembl 12 -58.8 -58801 1.1 MEIS2 PKNOX1 JUN MAFG ZNF316 MAFF POLR2A EMSY MAFK SPI1 ZADH2 TSHZ1 GC18M075233 ENSG00000276993
GH18I075276 Enhancer 0.5 Ensembl ENCODE 11.4 -68.0 -67987 2.1 ZNF266 ZNF407 ZADH2 TSHZ1 CNDP2 GC18M075233 ENSG00000276993
GH18I075280 Enhancer 0.4 ENCODE 11.6 -71.4 -71430 0.8 JUN NR2F2 TSHZ1 ZADH2 GC18M075233 ENSG00000276993
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZADH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZADH2 gene promoter:

Genomic Locations for ZADH2 Gene

Genomic Locations for ZADH2 Gene
chr18:75,195,108-75,209,348
(GRCh38/hg38)
Size:
14,241 bases
Orientation:
Minus strand
chr18:72,907,063-72,921,303
(GRCh37/hg19)

Genomic View for ZADH2 Gene

Genes around ZADH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZADH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZADH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZADH2 Gene

Proteins for ZADH2 Gene

  • Protein details for ZADH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4Q0-PTGR3_HUMAN
    Recommended name:
    Prostaglandin reductase 3
    Protein Accession:
    Q8N4Q0
    Secondary Accessions:
    • A8KA15
    • B4DZ91

    Protein attributes for ZADH2 Gene

    Size:
    377 amino acids
    Molecular mass:
    40140 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZADH2 Gene

    Alternative splice isoforms for ZADH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZADH2 Gene

Post-translational modifications for ZADH2 Gene

No Post-translational modifications

Other Protein References for ZADH2 Gene

No data available for DME Specific Peptides for ZADH2 Gene

Domains & Families for ZADH2 Gene

Gene Families for ZADH2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q8N4Q0

UniProtKB/Swiss-Prot:

PTGR3_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with ZADH2: view

Function for ZADH2 Gene

Molecular function for ZADH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

Enzyme Numbers (IUBMB) for ZADH2 Gene

Phenotypes From GWAS Catalog for ZADH2 Gene

Gene Ontology (GO) - Molecular Function for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0036132 13-prostaglandin reductase activity ISS --
GO:0047522 15-oxoprostaglandin 13-oxidase activity IEA --
genes like me logo Genes that share ontologies with ZADH2: view
genes like me logo Genes that share phenotypes with ZADH2: view

Animal Model Products

CRISPR Products

miRNA for ZADH2 Gene

miRTarBase miRNAs that target ZADH2

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZADH2 Gene

Localization for ZADH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZADH2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZADH2 gene
Compartment Confidence
peroxisome 5
mitochondrion 3
cytosol 3
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome ISS --
genes like me logo Genes that share ontologies with ZADH2: view

Pathways & Interactions for ZADH2 Gene

SuperPathways for ZADH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IEA --
GO:0008150 biological_process ND --
GO:0045599 negative regulation of fat cell differentiation ISS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ZADH2: view

No data available for Pathways by source and SIGNOR curated interactions for ZADH2 Gene

Drugs & Compounds for ZADH2 Gene

(3) Drugs for ZADH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved, Investigational Pharma 0
Propyl alcohol Approved, Experimental Pharma 0
1-Butanol Experimental Pharma 0

(3) Additional Compounds for ZADH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
genes like me logo Genes that share compounds with ZADH2: view

Transcripts for ZADH2 Gene

Unigene Clusters for ZADH2 Gene

Zinc binding alcohol dehydrogenase domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZADH2 Gene

No ASD Table

Relevant External Links for ZADH2 Gene

GeneLoc Exon Structure for
ZADH2
ECgene alternative splicing isoforms for
ZADH2

Expression for ZADH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZADH2 Gene

Protein differential expression in normal tissues from HIPED for ZADH2 Gene

This gene is overexpressed in Stomach (7.9) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZADH2 Gene



Protein tissue co-expression partners for ZADH2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZADH2 Gene:

ZADH2

SOURCE GeneReport for Unigene cluster for ZADH2 Gene:

Hs.465433
genes like me logo Genes that share expression patterns with ZADH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZADH2 Gene

Orthologs for ZADH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZADH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZADH2 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia ZADH2 33 34
  • 89.74 (n)
cow
(Bos Taurus)
Mammalia ZADH2 33 34
  • 85.15 (n)
oppossum
(Monodelphis domestica)
Mammalia ZADH2 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zadh2 33 16 34
  • 84.53 (n)
rat
(Rattus norvegicus)
Mammalia Zadh2 33
  • 84.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZADH2 33 34
  • 79.42 (n)
lizard
(Anolis carolinensis)
Reptilia ZADH2 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zadh2 33
  • 73.08 (n)
Str.17735 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14187 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 34
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NQR 33
  • 52.63 (n)
rice
(Oryza sativa)
Liliopsida Os09g0459800 33
  • 49.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2016 33
Species where no ortholog for ZADH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZADH2 Gene

ENSEMBL:
Gene Tree for ZADH2 (if available)
TreeFam:
Gene Tree for ZADH2 (if available)

Paralogs for ZADH2 Gene

Paralogs for ZADH2 Gene

(2) SIMAP similar genes for ZADH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZADH2: view

Variants for ZADH2 Gene

Sequence variations from dbSNP and Humsavar for ZADH2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1048510806 uncertain-significance, Aural atresia, congenital 75,211,222(-) C/T upstream_transcript_variant
rs147012982 likely-benign, Aural atresia, congenital 75,211,154(-) G/C upstream_transcript_variant
rs181312859 likely-benign, Aural atresia, congenital 75,211,233(-) C/A upstream_transcript_variant
rs369841992 likely-benign, Aural atresia, congenital 75,211,134(-) CCCCCC/CCCCCCC upstream_transcript_variant
rs372174307 uncertain-significance, Aural atresia, congenital 75,211,003(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZADH2 Gene

Variant ID Type Subtype PubMed ID
esv3643133 CNV loss 21293372
nsv1072812 CNV deletion 25765185
nsv833695 CNV gain 17160897

Variation tolerance for ZADH2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZADH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZADH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZADH2 Gene

Disorders for ZADH2 Gene

Additional Disease Information for ZADH2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZADH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZADH2 Gene

Publications for ZADH2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough CW … Bowden DW (Human genetics 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZADH2 Gene

  • Addgene plasmids for ZADH2

Sources for ZADH2 Gene

Content
Loading form....