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Aliases for ZADH2 Gene

Aliases for ZADH2 Gene

  • Zinc Binding Alcohol Dehydrogenase Domain Containing 2 2 3 5
  • EC 1.-.-.- 4

External Ids for ZADH2 Gene

Previous GeneCards Identifiers for ZADH2 Gene

  • GC18M071038
  • GC18M071041
  • GC18M072907
  • GC18M069594

Summaries for ZADH2 Gene

GeneCards Summary for ZADH2 Gene

ZADH2 (Zinc Binding Alcohol Dehydrogenase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and transferase activity, transferring acyl groups other than amino-acyl groups. An important paralog of this gene is CRYZ.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZADH2 Gene

Genomics for ZADH2 Gene

Regulatory Elements for ZADH2 Gene

Promoters for ZADH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZADH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZADH2 Gene

Chromosome:
18
Start:
75,195,108 bp from pter
End:
75,209,348 bp from pter
Size:
14,241 bases
Orientation:
Minus strand

Genomic View for ZADH2 Gene

Genes around ZADH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZADH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZADH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZADH2 Gene

Proteins for ZADH2 Gene

  • Protein details for ZADH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4Q0-ZADH2_HUMAN
    Recommended name:
    Zinc-binding alcohol dehydrogenase domain-containing protein 2
    Protein Accession:
    Q8N4Q0
    Secondary Accessions:
    • A8KA15
    • B4DZ91

    Protein attributes for ZADH2 Gene

    Size:
    377 amino acids
    Molecular mass:
    40140 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ZADH2 Gene

    Alternative splice isoforms for ZADH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZADH2 Gene

Proteomics data for ZADH2 Gene at MOPED

Post-translational modifications for ZADH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZADH2 Gene

No data available for DME Specific Peptides for ZADH2 Gene

Domains & Families for ZADH2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N4Q0

UniProtKB/Swiss-Prot:

ZADH2_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
genes like me logo Genes that share domains with ZADH2: view

No data available for Gene Families for ZADH2 Gene

Function for ZADH2 Gene

Enzyme Numbers (IUBMB) for ZADH2 Gene

Gene Ontology (GO) - Molecular Function for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ZADH2: view
genes like me logo Genes that share phenotypes with ZADH2: view

Animal Model Products

miRNA for ZADH2 Gene

miRTarBase miRNAs that target ZADH2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZADH2 Gene

Localization for ZADH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZADH2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZADH2 Gene COMPARTMENTS Subcellular localization image for ZADH2 gene
Compartment Confidence
peroxisome 5
cytosol 3
mitochondrion 3
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ZADH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ZADH2: view

Pathways & Interactions for ZADH2 Gene

SuperPathways for ZADH2 Gene

No Data Available

Interacting Proteins for ZADH2 Gene

Gene Ontology (GO) - Biological Process for ZADH2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZADH2 Gene

Drugs & Compounds for ZADH2 Gene

(2) Drugs for ZADH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0

(4) Additional Compounds for ZADH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
67-63-0
genes like me logo Genes that share compounds with ZADH2: view

Transcripts for ZADH2 Gene

Unigene Clusters for ZADH2 Gene

Zinc binding alcohol dehydrogenase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZADH2 Gene

No ASD Table

Relevant External Links for ZADH2 Gene

GeneLoc Exon Structure for
ZADH2
ECgene alternative splicing isoforms for
ZADH2

Expression for ZADH2 Gene

mRNA expression in normal human tissues for ZADH2 Gene

Protein differential expression in normal tissues from HIPED for ZADH2 Gene

This gene is overexpressed in Stomach (7.9) and Heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZADH2 Gene



SOURCE GeneReport for Unigene cluster for ZADH2 Gene Hs.465433

genes like me logo Genes that share expression patterns with ZADH2: view

Protein tissue co-expression partners for ZADH2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZADH2 Gene

Orthologs for ZADH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZADH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZADH2 35
  • 85.15 (n)
  • 87.53 (a)
ZADH2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZADH2 35
  • 89.74 (n)
  • 90.19 (a)
ZADH2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zadh2 35
  • 84.53 (n)
  • 88.06 (a)
Zadh2 16
Zadh2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZADH2 35
  • 99.29 (n)
  • 99.47 (a)
ZADH2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zadh2 35
  • 84.53 (n)
  • 88.86 (a)
oppossum
(Monodelphis domestica)
Mammalia ZADH2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZADH2 35
  • 79.42 (n)
  • 81.03 (a)
ZADH2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZADH2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17735 35
zadh2 35
  • 73.08 (n)
  • 76.69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14187 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZTA1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NQR 35
  • 52.63 (n)
  • 47.27 (a)
rice
(Oryza sativa)
Liliopsida Os09g0459800 35
  • 49.42 (n)
  • 46.53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2016 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for ZADH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZADH2 Gene

ENSEMBL:
Gene Tree for ZADH2 (if available)
TreeFam:
Gene Tree for ZADH2 (if available)

Paralogs for ZADH2 Gene

Paralogs for ZADH2 Gene

(2) SIMAP similar genes for ZADH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZADH2: view

Variants for ZADH2 Gene

Sequence variations from dbSNP and Humsavar for ZADH2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs17056661 - 75,201,582(+) TCACA(A/C)ACATC reference, missense
rs9240 -- 75,198,732(-) GCTTA(A/G)GGTCA utr-variant-3-prime
rs590483 -- 75,194,972(+) TGATT(C/T)TGGGC downstream-variant-500B
rs632157 -- 75,199,593(-) CCACA(C/T)GGAAA utr-variant-3-prime
rs634687 -- 75,195,005(+) GATAT(G/T)CTGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZADH2 Gene

Variant ID Type Subtype PubMed ID
nsv833695 CNV Gain 17160897

Variation tolerance for ZADH2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZADH2 Gene

HapMap Linkage Disequilibrium report
ZADH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZADH2 Gene

Disorders for ZADH2 Gene

Relevant External Links for ZADH2

Genetic Association Database (GAD)
ZADH2
Human Genome Epidemiology (HuGE) Navigator
ZADH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZADH2

No disorders were found for ZADH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZADH2 Gene

Publications for ZADH2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid beta-oxidation in peroxisomal matrix. (PMID: 22002062) Okumoto K. … Fujiki Y. (J. Biol. Chem. 2011) 3

Products for ZADH2 Gene

Sources for ZADH2 Gene

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