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ZADH2 Gene

protein-coding   GIFtS: 48
GCID: GC18M072907

Zinc Binding Alcohol Dehydrogenase Domain Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Binding Alcohol Dehydrogenase Domain Containing 21 2
Zinc-Binding Alcohol Dehydrogenase Domain-Containing Protein 22
EC 1.-.-.-3

External Ids:    HGNC: 286971   Entrez Gene: 2842732   Ensembl: ENSG000001800117   UniProtKB: Q8N4Q03   

Export aliases for ZADH2 gene to outside databases

Previous GC identifers: GC18M071038 GC18M071041 GC18M069594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZADH2 Gene:
ZADH2 (zinc binding alcohol dehydrogenase domain containing 2) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is VAT1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZADH2 gene promoter:
         GR   Sox5   GATA-3   GR-beta   FOXD3   LCR-F1   GATA-2   GATA-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZADH2 promoter sequence
   Search Chromatin IP Primers for ZADH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZADH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

ZADH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZADH2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M072907:  view genomic region     (about GC identifiers)

Start:
72,907,063 bp from pter      End:
72,921,303 bp from pter
Size:
14,241 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0 (See protein sequence)
Recommended Name: Zinc-binding alcohol dehydrogenase domain-containing protein 2  
Size: 377 amino acids; 40140 Da
4 PDB 3D structures from and Proteopedia for ZADH2:
2C0C (3D)        2WEK (3D)        2X1H (3D)        2X7H (3D)    
Secondary accessions: A8KA15

Explore the universe of human proteins at neXtProt for ZADH2: NX_Q8N4Q0

Explore proteomics data for ZADH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZADH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787103.1  
    ENSEMBL proteins: 
     ENSP00000323678   ENSP00000440111   ENSP00000463106   ENSP00000463844  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR013154 ADH_GroES-like
     IPR002364 Quin_OxRdtase/zeta-crystal_CS
     IPR002085 ADH_SF_Zn-type

    Graphical View of Domain Structure for InterPro Entry Q8N4Q0

    ProtoNet protein and cluster: Q8N4Q0

    1 Blocks protein domain: IPB002364 Quinone oxidoreductase/zeta-crystallin

    UniProtKB/Swiss-Prot: ZADH2_HUMAN, Q8N4Q0
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    Find genes that share domains with ZADH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008270zinc ion binding IEA--
    GO:0016491oxidoreductase activity IEA--
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    Find genes that share ontologies with ZADH2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZADH2:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZADH2
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    miRNA
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    miRTarBase miRNAs that target ZADH2:
    hsa-mir-27b-3p (MIRT046194), hsa-let-7b-5p (MIRT032369), hsa-mir-192-5p (MIRT026459), hsa-mir-107 (MIRT048302), hsa-mir-21-5p (MIRT030901), hsa-mir-93-5p (MIRT028008)

    Block miRNA regulation of human, mouse, rat ZADH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZADH2 (see all 137):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-3938 hsa-miR-520f hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidZADH2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZADH2_HUMAN, Q8N4Q0: Peroxisome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome4
    cytosol3
    mitochondrion2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome ISS--

    Find genes that share ontologies with ZADH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZADH2
    Interactions:

        Search GeneGlobe Interaction Network for ZADH2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZADH2 (ENSP000003236784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    HAT1ENSP000002641084STRING: ENSP00000264108
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ZADH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZADH2

    7 HMDB Compounds for ZADH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZADH2 gene: 
    NM_175907.4  

    Unigene Cluster for ZADH2:

    Zinc binding alcohol dehydrogenase domain containing 2
    Hs.465433  [show with all ESTs]
    Unigene Representative Sequence: NM_175907
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322342(uc010dqv.3 uc002llx.3) ENST00000537114 ENST00000582437
    ENST00000581620
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZADH2 (see all 137):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-3938 hsa-miR-520f hsa-miR-640 hsa-miR-106a hsa-miR-128 hsa-miR-3653
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      QuantiTect SYBR Green Assays in human, mouse, rat ZADH2
      QuantiFast Probe-based Assays in human, mouse, rat ZADH2

    Additional mRNA sequence: 

    AK292880.1 AK302801.1 BC010734.1 BC018081.1 BC033780.1 BC064618.1 BC075853.1 BC078661.1 
    BX647730.1 

    8 DOTS entries:

    DT.95274619  DT.443614  DT.306220  DT.100764180  DT.306710  DT.100799321  DT.121087709  DT.91916927 

    Selected AceView cDNA sequences (see all 170):

    BM975841 AI698115 BC010734 AI698106 BM129804 Z39720 BM682176 CA441598 
    CR610486 BX647730 BC064618 AW134753 AI802990 BQ940777 N94610 AA780047 
    BG576904 AW297357 BE671522 CA443759 AA442520 C05192 CA429611 AI608774 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZADH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAAGAGGG
    ZADH2 Expression
    About this image

    ZADH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZADH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465433
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZADH2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zadh21 , 5 zinc binding alcohol dehydrogenase, domain containing more1, 5 84.53(n)1
    88.06(a)1
      18 (57.53 cM)5
    2257911  NM_146090.51  NP_666202.21 
     840881585 
    chicken
    (Gallus gallus)
    Aves ZADH21 zinc binding alcohol dehydrogenase domain containing more 79.42(n)
    81.03(a)
      421010  XM_419096.4  XP_419096.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZADH26
    zinc binding alcohol dehydrogenase domain containi...
    73(a)
    1 ↔ 1
    4(49787391-49798579)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.141872 Xenopus laevis transcribed sequence with weak similarity more 76.38(n)    CB198142.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZTA16
    NADPH-dependent quinone reductase, GFP-tagged prot...
    26(a)
    1 → many
    II(330507-331511) YBR046C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NQR1 NQR 52.63(n)
    47.27(a)
      841391  NM_103855.4  NP_175390.2 
    rice
    (Oryza sativa)
    Liliopsida Os09g04598001 Os09g0459800 49.42(n)
    46.53(a)
      4347279  NM_001069918.1  NP_001063383.1 


    ENSEMBL Gene Tree for ZADH2 (if available)
    TreeFam Gene Tree for ZADH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZADH2 gene
    VAT12  VAT1L2  CRYZ2  TP53I32  
    2 SIMAP similar genes for ZADH2 using alignment to 5 protein entries:     ZADH2_HUMAN (see all proteins):
    PTGR1    VAT1

    Find genes that share paralogs with ZADH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZADH2 (see all 306)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423169851,2
    C--72908866(+) GAAAC-/AATT  
            
    AAACA
    1 -- ds50010--------
    rs101639111,2
    C,F--72909097(+) TGATGC/TTATAA 1 -- ds50012Minor allele frequency- T:0.08WA NA 238
    rs10475281,2
    F--72909134(-) TTTTTA/C/TTTTTT 1 -- ds50012NA 4
    rs1807008801,2
    --72909165(+) TTTGAG/TAGCAA 1 -- ds50010--------
    rs1510787101,2
    --72909280(+) TTCTCC/TATGAT 1 -- ut310--------
    rs11295621,2
    C,H--72909321(-) GATGTC/GTTGAA 1 -- ut316Minor allele frequency- G:0.48NA EA 248
    rs1413706091,2
    C--72909348(+) TATATA/GCACCT 1 -- ut310--------
    rs1446718111,2
    --72909365(+) TACCCA/GTAAGA 1 -- ut310--------
    rs1386095171,2
    C--72909422(+) CAACCA/GTATTG 1 -- ut310--------
    rs1415114551,2
    --72909491(+) CCAACC/TGTACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZADH2 (72907063 - 72921303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZADH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833695CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZADH2           About GenesLikeMe

    Genetic Association Database (GAD): ZADH2
    Human Genome Epidemiology (HuGE) Navigator: ZADH2 (2 documents)

    Export disorders for ZADH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZADH2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ZADH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (Hum. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid beta-oxidation in peroxisomal matrix. (PubMed id 22002062)1 Okumoto K.... Fujiki Y. (J. Biol. Chem. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284273 HGNC: 28697 AceView: ZADH2 Ensembl:ENSG00000180011 euGenes: HUgn284273
    ECgene: ZADH2 H-InvDB: ZADH2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZADH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZADH2 gene:
    Search GeneIP for patents involving ZADH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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