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Aliases for ZACN Gene

Aliases for ZACN Gene

  • Zinc Activated Ion Channel 2 3 5
  • Ligand-Gated Ion Channel Zinc-Activated 1 3 4
  • Ligand-Gated Ion-Channel Receptor L2 3 4
  • LGICZ1 3 4
  • LGICZ 3 4
  • ZAC 3 4
  • L2 3 4
  • Ligand-Gated Ion Channel, Zinc Activated 1 2
  • Zinc Activated Ligand-Gated Ion Channel 1 3
  • Zinc Activated Ligand-Gated Ion Channel 2
  • Zinc-Activated Ligand-Gated Ion Channel 3
  • Ligand-Gated Ion Channel Subunit 3
  • ZAC1 3

External Ids for ZACN Gene

Previous HGNC Symbols for ZACN Gene

  • LGICZ1

Previous GeneCards Identifiers for ZACN Gene

  • GC17P071588
  • GC17P074075
  • GC17P069504

Summaries for ZACN Gene

Entrez Gene Summary for ZACN Gene

  • LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZACN Gene

ZACN (Zinc Activated Ion Channel) is a Protein Coding gene. GO annotations related to this gene include extracellular ligand-gated ion channel activity and ligand-gated ion channel activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot for ZACN Gene

  • Zinc-activated ligand-gated ion channel.

Gene Wiki entry for ZACN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZACN Gene

Genomics for ZACN Gene

Regulatory Elements for ZACN Gene

Enhancers for ZACN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G075926 0.7 ENCODE 11.2 -144.9 -144925 1.9 ZNF263 GATAD2A CTCF ARID4B ELF4 ATF2 ZNF48 RAD21 ZNF316 POLR2A FBF1 ZACN SRP68 GALR2 ENSG00000267426 MRPL38
GH17G076049 0.6 ENCODE 12.2 -20.8 -20779 2.5 PKNOX1 ESRRA ZHX2 ZNF217 CTBP1 GATA3 MTA1 RCOR1 FOSL2 FOS SRP68 EVPL GALR2 ZACN CDK3 EXOC7 MRPL38 QRICH2 FBF1 PIR59290
GH17G075922 0.6 ENCODE 11.2 -148.5 -148521 1.2 TFAP4 NFIA SCRT2 MXD4 NR2F6 HNRNPL NR2C2 TRIM65 SRP68 ZACN GALR2 ENSG00000267426 MRPL38
GH17G076048 0.5 ENCODE 11.8 -23.1 -23129 0.4 RFX1 NRF1 TEAD4 BMI1 EVPL CDK3 GALR2 SRP68 ZACN EXOC7 FBF1 AANAT UBE2O PIR59290
GH17G076138 1.3 FANTOM5 ENCODE 1.4 +66.7 66733 1.3 HDGF FOXA2 ZFP64 ARID4B DMAP1 ZNF48 GLIS2 SP5 MXD4 NFYC RNF157-AS1 FOXJ1 PRPSAP1 ZACN RECQL5 PIR38709 GC17M076139
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZACN on UCSC Golden Path with GeneCards custom track

Genomic Location for ZACN Gene

Chromosome:
17
Start:
76,071,961 bp from pter
End:
76,083,666 bp from pter
Size:
11,706 bases
Orientation:
Plus strand

Genomic View for ZACN Gene

Genes around ZACN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZACN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZACN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZACN Gene

Proteins for ZACN Gene

  • Protein details for ZACN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q401N2-ZACN_HUMAN
    Recommended name:
    Zinc-activated ligand-gated ion channel
    Protein Accession:
    Q401N2
    Secondary Accessions:
    • Q2TB29
    • Q6ZWK3
    • Q86YW4

    Protein attributes for ZACN Gene

    Size:
    412 amino acids
    Molecular mass:
    45816 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse and rat orthologous proteins do not exist.
    SequenceCaution:
    • Sequence=AAI10598.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO20969.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW89365.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZACN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZACN Gene

Post-translational modifications for ZACN Gene

Other Protein References for ZACN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZACN Gene

Domains & Families for ZACN Gene

Gene Families for ZACN Gene

Suggested Antigen Peptide Sequences for ZACN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q401N2

UniProtKB/Swiss-Prot:

ZACN_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
genes like me logo Genes that share domains with ZACN: view

Function for ZACN Gene

Molecular function for ZACN Gene

UniProtKB/Swiss-Prot Function:
Zinc-activated ligand-gated ion channel.

Gene Ontology (GO) - Molecular Function for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0008270 zinc ion binding IC 12381728
GO:0015276 ligand-gated ion channel activity IDA 12381728
genes like me logo Genes that share ontologies with ZACN: view
genes like me logo Genes that share phenotypes with ZACN: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZACN Gene

Localization for ZACN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZACN Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZACN gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16083862
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZACN: view

Pathways & Interactions for ZACN Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007210 serotonin receptor signaling pathway IBA --
GO:0010043 response to zinc ion IDA 12381728
GO:0034220 ion transmembrane transport IDA 12381728
genes like me logo Genes that share ontologies with ZACN: view

No data available for Pathways by source and SIGNOR curated interactions for ZACN Gene

Drugs & Compounds for ZACN Gene

(4) Drugs for ZACN Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tubocurarine Approved Pharma antagonist 0
Zn<sup>2+</sup> Pharma Positive, Allosteric regulator 0

(2) Additional Compounds for ZACN Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker
genes like me logo Genes that share compounds with ZACN: view

Transcripts for ZACN Gene

mRNA/cDNA for ZACN Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZACN Gene

Zinc activated ligand-gated ion channel:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZACN Gene

No ASD Table

Relevant External Links for ZACN Gene

GeneLoc Exon Structure for
ZACN
ECgene alternative splicing isoforms for
ZACN

Expression for ZACN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZACN Gene

mRNA differential expression in normal tissues according to GTEx for ZACN Gene

This gene is overexpressed in Colon - Sigmoid (x18.5), Small Intestine - Terminal Ileum (x14.0), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for ZACN Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZACN Gene



Protein tissue co-expression partners for ZACN Gene

NURSA nuclear receptor signaling pathways regulating expression of ZACN Gene:

ZACN

SOURCE GeneReport for Unigene cluster for ZACN Gene:

Hs.714919

mRNA Expression by UniProt/SwissProt for ZACN Gene:

Q401N2-ZACN_HUMAN
Tissue specificity: Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.

Evidence on tissue expression from TISSUES for ZACN Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZACN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZACN Gene

Orthologs for ZACN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZACN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZACN 34 35
  • 98.07 (n)
dog
(Canis familiaris)
Mammalia ZACN 34 35
  • 82.69 (n)
cow
(Bos Taurus)
Mammalia ZACN 34 35
  • 79.57 (n)
oppossum
(Monodelphis domestica)
Mammalia ZACN 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZACN 35
  • 15 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZACN 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZACN (5 of 5) 35
  • 21 (a)
OneToMany
ZACN (1 of 5) 35
  • 20 (a)
OneToMany
ZACN (4 of 5) 35
  • 20 (a)
OneToMany
ZACN (2 of 5) 35
  • 18 (a)
OneToMany
ZACN (3 of 5) 35
  • 18 (a)
OneToMany
Species where no ortholog for ZACN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZACN Gene

ENSEMBL:
Gene Tree for ZACN (if available)
TreeFam:
Gene Tree for ZACN (if available)

Paralogs for ZACN Gene

Paralogs for ZACN Gene

Pseudogenes.org Pseudogenes for ZACN Gene

genes like me logo Genes that share paralogs with ZACN: view

Variants for ZACN Gene

Sequence variations from dbSNP and Humsavar for ZACN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000120615 -- 76,078,463(+) TCTTT(-/TTG)TTGTT upstream-variant-2KB
rs1000579419 -- 76,079,848(+) GATAT(A/G)TGGAG intron-variant
rs1000607854 -- 76,081,563(+) ACACG(G/T)CGCTC reference, missense, utr-variant-3-prime
rs1000650918 -- 76,080,643(+) AGCCC(A/G)TCTCT intron-variant, downstream-variant-500B
rs1001156691 -- 76,077,516(+) TAAAA(A/C/G)GCACA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZACN Gene

Variant ID Type Subtype PubMed ID
nsv2142 CNV insertion 18451855
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897

Variation tolerance for ZACN Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZACN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZACN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZACN Gene

Disorders for ZACN Gene

Relevant External Links for ZACN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZACN

No disorders were found for ZACN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZACN Gene

Publications for ZACN Gene

  1. Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. (PMID: 16083862) Houtani T. … Sugimoto T. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 22 64
  2. A novel class of ligand-gated ion channel is activated by Zn2+. (PMID: 12381728) Davies P.A. … Kirkness E.F. (J. Biol. Chem. 2003) 2 3 4 22 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Semisynthesis of NaK, a Na(+) and K(+) conducting ion channel. (PMID: 20415433) Linn K.M. … Valiyaveetil F.I. (Biochemistry 2010) 22 64
  5. The Seventh Annual Ion Channel Retreat Vancouver, Canada, June 29-July 1, 2009. (PMID: 20158438) Brugger S. … King N. (Assay Drug Dev Technol 2010) 22 64

Products for ZACN Gene

Sources for ZACN Gene

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