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Aliases for ZACN Gene

Aliases for ZACN Gene

  • Zinc Activated Ligand-Gated Ion Channel 2 3
  • Ligand-Gated Ion Channel, Zinc Activated 1 2 3
  • Ligand-Gated Ion Channel Zinc-Activated 1 3 4
  • Ligand-Gated Ion-Channel Receptor L2 3 4
  • LGICZ1 3 4
  • LGICZ 3 4
  • ZAC 3 4
  • L2 3 4
  • Zinc Activated Ligand-Gated Ion Channel 1 3
  • Ligand-Gated Ion Channel Subunit 3
  • ZAC1 3

External Ids for ZACN Gene

Previous HGNC Symbols for ZACN Gene

  • LGICZ1

Previous GeneCards Identifiers for ZACN Gene

  • GC17P071588
  • GC17P074075
  • GC17P069504

Summaries for ZACN Gene

Entrez Gene Summary for ZACN Gene

  • LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZACN Gene

ZACN (Zinc Activated Ligand-Gated Ion Channel) is a Protein Coding gene. Diseases associated with ZACN include diabetes mellitus, transient neonatal, 1. GO annotations related to this gene include extracellular ligand-gated ion channel activity and ligand-gated ion channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for ZACN Gene

  • Zinc-activated ligand-gated ion channel.

Gene Wiki entry for ZACN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZACN Gene

Genomics for ZACN Gene

Regulatory Elements for ZACN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZACN Gene

Chromosome:
17
Start:
76,071,961 bp from pter
End:
76,083,666 bp from pter
Size:
11,706 bases
Orientation:
Plus strand

Genomic View for ZACN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZACN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZACN Gene

Proteins for ZACN Gene

  • Protein details for ZACN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q401N2-ZACN_HUMAN
    Recommended name:
    Zinc-activated ligand-gated ion channel
    Protein Accession:
    Q401N2
    Secondary Accessions:
    • Q2TB29
    • Q6ZWK3
    • Q86YW4

    Protein attributes for ZACN Gene

    Size:
    412 amino acids
    Molecular mass:
    45816 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse and rat orthologous proteins do not exist
    SequenceCaution:
    • Sequence=AAI10598.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO20969.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW89365.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZACN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZACN Gene

Proteomics data for ZACN Gene at MOPED

Post-translational modifications for ZACN Gene

Other Protein References for ZACN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZACN Gene

Domains & Families for ZACN Gene

Gene Families for ZACN Gene

Suggested Antigen Peptide Sequences for ZACN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q401N2

UniProtKB/Swiss-Prot:

ZACN_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
genes like me logo Genes that share domains with ZACN: view

Function for ZACN Gene

Molecular function for ZACN Gene

UniProtKB/Swiss-Prot Function:
Zinc-activated ligand-gated ion channel.

Gene Ontology (GO) - Molecular Function for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004889 contributes_to acetylcholine-activated cation-selective channel activity IBA --
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0008270 zinc ion binding IC 12381728
GO:0015276 ligand-gated ion channel activity IDA 12381728
GO:0015464 contributes_to acetylcholine receptor activity IBA --
genes like me logo Genes that share ontologies with ZACN: view

Phenotypes for ZACN Gene

GenomeRNAi human phenotypes for ZACN:
genes like me logo Genes that share phenotypes with ZACN: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZACN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZACN Gene

Localization for ZACN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZACN Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZACN Gene COMPARTMENTS Subcellular localization image for ZACN gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16083862
GO:0005892 acetylcholine-gated channel complex IBA --
GO:0016020 membrane --
GO:0043005 neuron projection IBA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with ZACN: view

Pathways & Interactions for ZACN Gene

SuperPathways for ZACN Gene

No Data Available

Interacting Proteins for ZACN Gene

Gene Ontology (GO) - Biological Process for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007165 signal transduction IBA --
GO:0007271 synaptic transmission, cholinergic IBA --
GO:0007274 neuromuscular synaptic transmission IBA --
genes like me logo Genes that share ontologies with ZACN: view

No data available for Pathways by source and SIGNOR curated interactions for ZACN Gene

Drugs & Compounds for ZACN Gene

(4) Drugs for ZACN Gene - From: NovoSeek, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tubocurarine Approved Pharma antagonist 0
Potassium Experimental Pharma 0
Zn<sup>2+</sup> Pharma Channel blocker 0
Calcium Nutra 0

(2) Additional Compounds for ZACN Gene - From: IUPHAR and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with ZACN: view

Transcripts for ZACN Gene

mRNA/cDNA for ZACN Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZACN Gene

Zinc activated ligand-gated ion channel:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZACN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZACN Gene

No ASD Table

Relevant External Links for ZACN Gene

GeneLoc Exon Structure for
ZACN
ECgene alternative splicing isoforms for
ZACN

Expression for ZACN Gene

mRNA expression in normal human tissues for ZACN Gene

mRNA differential expression in normal tissues according to GTEx for ZACN Gene

This gene is overexpressed in Colon - Sigmoid (x18.5), Small Intestine - Terminal Ileum (x14.0), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for ZACN Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZACN Gene



SOURCE GeneReport for Unigene cluster for ZACN Gene Hs.714919

mRNA Expression by UniProt/SwissProt for ZACN Gene

Q401N2-ZACN_HUMAN
Tissue specificity: Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.
genes like me logo Genes that share expression patterns with ZACN: view

Protein tissue co-expression partners for ZACN Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZACN Gene

Orthologs for ZACN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZACN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZACN 35
  • 79.57 (n)
  • 71.79 (a)
ZACN 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZACN 35
  • 82.69 (n)
  • 78.15 (a)
ZACN 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZACN 35
  • 98.07 (n)
  • 96.73 (a)
ZACN 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZACN 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZACN 36
  • 15 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZACN 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZACN (1 of 5) 36
  • 20 (a)
OneToMany
ZACN (2 of 5) 36
  • 18 (a)
OneToMany
ZACN (3 of 5) 36
  • 18 (a)
OneToMany
ZACN (4 of 5) 36
  • 20 (a)
OneToMany
ZACN (5 of 5) 36
  • 21 (a)
OneToMany
Species with no ortholog for ZACN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZACN Gene

ENSEMBL:
Gene Tree for ZACN (if available)
TreeFam:
Gene Tree for ZACN (if available)

Paralogs for ZACN Gene

Paralogs for ZACN Gene

Pseudogenes.org Pseudogenes for ZACN Gene

genes like me logo Genes that share paralogs with ZACN: view

Variants for ZACN Gene

Sequence variations from dbSNP and Humsavar for ZACN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs881265 -- 76,078,829(-) CTTGA(A/G)AGTCT upstream-variant-2KB
rs2256879 -- 76,079,151(+) CCCCA(A/G)AGTCC upstream-variant-2KB
rs2257020 - 76,080,334(+) CCCTC(A/G)CCACG missense, reference
rs2443164 -- 76,078,133(+) AGAGG(G/T)TTTTT upstream-variant-2KB
rs2443165 -- 76,078,148(+) TTCTG(G/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZACN Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294
nsv509674 CNV Insertion 20534489
nsv2142 CNV Insertion 18451855

Variation tolerance for ZACN Gene

Residual Variation Intolerance Score: 89.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZACN Gene

HapMap Linkage Disequilibrium report
ZACN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZACN Gene

Disorders for ZACN Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZACN Gene - From: OMIM

Disorder Aliases PubMed IDs
diabetes mellitus, transient neonatal, 1
  • diabetes mellitus, transient neonatal
- elite association
Search ZACN in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZACN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZACN
genes like me logo Genes that share disorders with ZACN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZACN Gene

Publications for ZACN Gene

  1. Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. (PMID: 16083862) Houtani T. … Sugimoto T. (Biochem. Biophys. Res. Commun. 2005) 2 23 67
  2. A novel class of ligand-gated ion channel is activated by Zn2+. (PMID: 12381728) Davies P.A. … Kirkness E.F. (J. Biol. Chem. 2003) 2 23 67
  3. The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins? (PMID: 20085760) Littler D.R. … Curmi P.M. (FEBS Lett. 2010) 23 67
  4. The Seventh Annual Ion Channel Retreat Vancouver, Canada, June 29-July 1, 2009. (PMID: 20158438) Brugger S. … King N. (Assay Drug Dev Technol 2010) 23 67
  5. Ion Channels as Therapeutic Targets--CHI's Fourth Annual Conference. (PMID: 20024841) Thorneloe K.S. (IDrugs 2010) 23 67

Products for ZACN Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZACN
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZACN
    • Block miRNA regulation of ZACN using miScript Target Protectors

    Sources for ZACN Gene

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