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Aliases for ZACN Gene

Aliases for ZACN Gene

  • Zinc Activated Ion Channel 2 3 5
  • Ligand-Gated Ion Channel Zinc-Activated 1 3 4
  • Ligand-Gated Ion-Channel Receptor L2 3 4
  • LGICZ1 3 4
  • LGICZ 3 4
  • ZAC 3 4
  • L2 3 4
  • Ligand-Gated Ion Channel, Zinc Activated 1 2
  • Zinc Activated Ligand-Gated Ion Channel 1 3
  • Zinc Activated Ligand-Gated Ion Channel 2
  • Zinc-Activated Ligand-Gated Ion Channel 3
  • Ligand-Gated Ion Channel Subunit 3
  • ZAC1 3

External Ids for ZACN Gene

Previous HGNC Symbols for ZACN Gene

  • LGICZ1

Previous GeneCards Identifiers for ZACN Gene

  • GC17P071588
  • GC17P074075
  • GC17P069504

Summaries for ZACN Gene

Entrez Gene Summary for ZACN Gene

  • LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of ligand-gated ion channels (Davies et al., 2003 [PubMed 12381728]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ZACN Gene

ZACN (Zinc Activated Ion Channel) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and ligand-gated ion channel activity. An important paralog of this gene is HTR3C.

UniProtKB/Swiss-Prot for ZACN Gene

  • Zinc-activated ligand-gated ion channel.

Gene Wiki entry for ZACN Gene

Additional gene information for ZACN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZACN Gene

Genomics for ZACN Gene

GeneHancer (GH) Regulatory Elements for ZACN Gene

Promoters and enhancers for ZACN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I076070 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.1 119 2.6 HDGF PKNOX1 MLX ARID4B SIN3A ZBTB7B IRF4 YY1 SLC30A9 POLR2B SRP68 ZACN GALR2 NUP85 SRSF2 UNK GGA3 NT5C ENSG00000266980 METTL23
GH17I076078 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 550.4 +8.0 7961 2.4 PAF1 CTCF ESRRA LEF1 MAZ CEBPB MAX JUND POLR2A ZBTB48 GC17P076081 ZACN SRP68 FOXJ1 EXOC7
GH17I075926 Enhancer 0.7 ENCODE 11.2 -144.9 -144924 1.9 GATAD2A CTCF ARID4B ELF1 ATF2 ZNF48 RAD21 POLR2A GABPB1 ZNF143 FBF1 SRP68 GALR2 ZACN ENSG00000267426 MRPL38
GH17I076049 Enhancer 0.5 ENCODE 12.2 -20.8 -20779 2.5 SMARCE1 ZNF217 CTBP1 PKNOX1 GATA3 FOSL2 FOS GC17P076053 PIR59290 SRP68 EVPL ZACN GALR2 CDK3 EXOC7 MRPL38 QRICH2
GH17I075922 Enhancer 0.5 ENCODE 11.2 -148.5 -148521 1.2 TFAP4 NFIA SCRT2 MXD4 NR2C2 TRIM65 ZACN SRP68 GALR2 ENSG00000267426 FBF1 MRPL38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZACN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZACN gene promoter:

Genomic Locations for ZACN Gene

Genomic Locations for ZACN Gene
chr17:76,071,961-76,083,666
(GRCh38/hg38)
Size:
11,706 bases
Orientation:
Plus strand
chr17:74,068,042-74,079,747
(GRCh37/hg19)

Genomic View for ZACN Gene

Genes around ZACN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZACN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZACN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZACN Gene

Proteins for ZACN Gene

  • Protein details for ZACN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q401N2-ZACN_HUMAN
    Recommended name:
    Zinc-activated ligand-gated ion channel
    Protein Accession:
    Q401N2
    Secondary Accessions:
    • Q2TB29
    • Q6ZWK3
    • Q86YW4

    Protein attributes for ZACN Gene

    Size:
    412 amino acids
    Molecular mass:
    45816 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse and rat orthologous proteins do not exist.
    SequenceCaution:
    • Sequence=AAI10598.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO20969.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW89365.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZACN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZACN Gene

Post-translational modifications for ZACN Gene

Other Protein References for ZACN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZACN Gene

Domains & Families for ZACN Gene

Gene Families for ZACN Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ZACN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q401N2

UniProtKB/Swiss-Prot:

ZACN_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family.
genes like me logo Genes that share domains with ZACN: view

Function for ZACN Gene

Molecular function for ZACN Gene

UniProtKB/Swiss-Prot Function:
Zinc-activated ligand-gated ion channel.

Gene Ontology (GO) - Molecular Function for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0008270 zinc ion binding IC 12381728
GO:0015276 ligand-gated ion channel activity IDA 12381728
GO:0022850 serotonin-gated cation-selective channel activity IBA --
genes like me logo Genes that share ontologies with ZACN: view
genes like me logo Genes that share phenotypes with ZACN: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZACN Gene

Localization for ZACN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZACN Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZACN gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 16083862
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZACN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZACN Gene

Pathways & Interactions for ZACN Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZACN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0010043 response to zinc ion IDA 12381728
GO:0034220 ion transmembrane transport IDA 12381728
genes like me logo Genes that share ontologies with ZACN: view

No data available for Pathways by source and SIGNOR curated interactions for ZACN Gene

Drugs & Compounds for ZACN Gene

(4) Drugs for ZACN Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tubocurarine Approved Pharma antagonist 0
Zn<sup>2+</sup> Pharma Positive, Allosteric regulator 0

(2) Additional Compounds for ZACN Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-tubocurarine
Antagonist, Pore Blocker
genes like me logo Genes that share compounds with ZACN: view

Transcripts for ZACN Gene

mRNA/cDNA for ZACN Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZACN Gene

Zinc activated ligand-gated ion channel:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZACN Gene

No ASD Table

Relevant External Links for ZACN Gene

GeneLoc Exon Structure for
ZACN
ECgene alternative splicing isoforms for
ZACN

Expression for ZACN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZACN Gene

mRNA differential expression in normal tissues according to GTEx for ZACN Gene

This gene is overexpressed in Colon - Sigmoid (x18.5), Small Intestine - Terminal Ileum (x14.0), and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for ZACN Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZACN Gene



Protein tissue co-expression partners for ZACN Gene

NURSA nuclear receptor signaling pathways regulating expression of ZACN Gene:

ZACN

SOURCE GeneReport for Unigene cluster for ZACN Gene:

Hs.714919

mRNA Expression by UniProt/SwissProt for ZACN Gene:

Q401N2-ZACN_HUMAN
Tissue specificity: Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus.

Evidence on tissue expression from TISSUES for ZACN Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZACN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZACN Gene

Orthologs for ZACN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZACN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZACN 33 34
  • 98.07 (n)
dog
(Canis familiaris)
Mammalia ZACN 33 34
  • 82.69 (n)
cow
(Bos Taurus)
Mammalia ZACN 33 34
  • 79.57 (n)
oppossum
(Monodelphis domestica)
Mammalia ZACN 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZACN 34
  • 15 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZACN 34
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZACN (5 of 5) 34
  • 21 (a)
OneToMany
ZACN (1 of 5) 34
  • 20 (a)
OneToMany
ZACN (4 of 5) 34
  • 20 (a)
OneToMany
ZACN (2 of 5) 34
  • 18 (a)
OneToMany
ZACN (3 of 5) 34
  • 18 (a)
OneToMany
Species where no ortholog for ZACN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZACN Gene

ENSEMBL:
Gene Tree for ZACN (if available)
TreeFam:
Gene Tree for ZACN (if available)

Paralogs for ZACN Gene

Paralogs for ZACN Gene

Pseudogenes.org Pseudogenes for ZACN Gene

genes like me logo Genes that share paralogs with ZACN: view

Variants for ZACN Gene

Sequence variations from dbSNP and Humsavar for ZACN Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000579419 -- 76,079,848(+) G/A intron_variant
rs1000607854 -- 76,081,563(+) G/T coding_sequence_variant, missense_variant
rs1000650918 -- 76,080,643(+) A/G intron_variant
rs1001156691 -- 76,077,516(+) C/A/G/T upstream_transcript_variant
rs1001201583 -- 76,077,971(+) /A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZACN Gene

Variant ID Type Subtype PubMed ID
nsv2142 CNV insertion 18451855
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897

Variation tolerance for ZACN Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZACN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZACN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZACN Gene

Disorders for ZACN Gene

Additional Disease Information for ZACN

No disorders were found for ZACN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZACN Gene

Publications for ZACN Gene

  1. Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. (PMID: 16083862) Houtani T … Sugimoto T (Biochemical and biophysical research communications 2005) 2 3 4 22 58
  2. A novel class of ligand-gated ion channel is activated by Zn2+. (PMID: 12381728) Davies PA … Kirkness EF (The Journal of biological chemistry 2003) 2 3 4 22 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Semisynthesis of NaK, a Na(+) and K(+) conducting ion channel. (PMID: 20415433) Linn KM … Valiyaveetil FI (Biochemistry 2010) 22 58

Products for ZACN Gene

Sources for ZACN Gene

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