Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZACN Gene

protein-coding GIFtS: 45
GCID: GC17P074075

zinc activated ligand-gated ion channel

(Previous names: ligand-gated ion channel, zinc activated 1 )
(Previous symbol: LGICZ1)

Explore 12 diseases affiliated with
ZACN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Activated Ligand-Gated Ion Channel¹ ²		Ligand-Gated Ion Channel, Zinc Activated 1¹ ²
L2¹ ² ³ ⁵		Ligand-Gated Ion Channel Zinc-Activated 1² ³
LGICZ1¹ ² ³ ⁵		Ligand-Gated Ion-Channel Receptor L2² ³
ZAC¹ ² ³ ⁵		Ligand-Gated Ion Channel Subunit²
LGICZ¹ ² ³		Zinc Activated Ligand-Gated Ion Channel 1²
ZAC1¹ ²		Zinc-Activated Ligand-Gated Ion Channel²

External Ids:	HGNC: 29504¹	Entrez Gene: 353174²	Ensembl: ENSG00000186919⁷	OMIM: 610935⁵	UniProtKB: Q401N2³

Export aliases for ZACN gene to outside databases

Previous GC identifers: GC17P071588 GC17P069504

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ZACN:

LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of

ligand-gated ion channels (Davies et al., 2003 (PubMed 12381728)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ZACN_HUMAN, Q401N2

Function: Zinc-activated ligand-gated ion channel

Gene Wiki entry for ZACN (Zinc-activated ion channel)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZACN gene promoter:
USF1 FAC1 USF-1 RREB-1 MyoD YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZACN promoter sequence

Search SABiosciences Chromatin IP Primers for ZACN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZACN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.3

ZACN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZACN gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P074075: view genomic region (about GC identifiers)

Start:	74,068,042 bp from pter	End:	74,079,747 bp from pter
Size:	11,706 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZACN_HUMAN, Q401N2 (See protein sequence)

Recommended Name: Zinc-activated ligand-gated ion channel precursor

Size: 412 amino acids; 45816 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Miscellaneous: The mouse and rat orthologous proteins do not exist

Caution: It is uncertain whether Met-1 or Met-2 is the initiator

Sequence caution: Sequence=AAI10598.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAO20969.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW89365.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q2TB29 Q6ZWK3 Q86YW4

Alternative splicing: 3 isoforms: Q401N2-1 Q401N2-2 Q401N2-3 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ZACN: NX_Q401N2

Post-translational modifications:

Glycosylated¹

View neXtProt modification sites for NX_Q401N2

ZACN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_851321.2

ENSEMBL proteins:

ENSP00000334854 ENSP00000397489 ENSP00000391936 ENSP00000376291

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ZACN OriGene Custom Protein Services for ZACN
	GenScript Custom Purified and Recombinant Proteins Services for ZACN
	Novus Biologicals ZACN Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ZACN

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	IDA	16083862
GO:0016021	integral to membrane	IEA	--
GO:0045211	postsynaptic membrane	IEA	--

ZACN for ontologies About GeneDecksing

ZACN Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ZACN
	GenScript Custom Superior Antibodies Services for ZACN
	Novus Biologicals ZACN Antibody
	Search for Antibodies for ZACN at Abcam
	Uscn Antibodies for ZACN
	ThermoFisher Antibodies for ZACN

Assay Products for ZACN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ZACN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ZACN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZACN for domains About GeneDecksing

4 InterPro domains/families:

IPR018000 Neurotransmitter_ion_chnl_CS

IPR006201 Neur_channel

IPR006202 Neur_chan_lig-bd

IPR006029 Neurotrans-gated_channel_TM

Graphical View of Domain Structure for InterPro Entry Q401N2

ProtoNet protein and cluster: Q401N2

1 Blocks protein family: IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: ZACN_HUMAN, Q401N2

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZACN_HUMAN, Q401N2

Function: Zinc-activated ligand-gated ion channel

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZACN
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZACN
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZACN OriGene shRNA RFP: ZACN OriGene siRNA: ZACN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZACN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ZACN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZACN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZACN (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZACN (NM_180990)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZACN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZACN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ZACN
		Search LifeMap BioReagents cell lines for ZACN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZACN

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0008270	zinc ion binding	IC	12381728

ZACN for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZACN

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010043	response to zinc ion	IDA	12381728

ZACN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ZACN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZACN
3 Novoseek chemical compound relationships for ZACN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
potassium	33.9	1	14657415 (1)
calcium	31.7	2	14657414 (1), 18702192 (1)
sodium	21	1	14657413 (1)

Search CenterWatch for drugs/clinical trials and news about ZACN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZACN gene:

NM_180990.3

Unigene Cluster for ZACN:

Zinc activated ligand-gated ion channel

Hs.714919 [show with all ESTs]

Unigene Representative Sequence: NM_180990

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591500 ENST00000524242 ENST00000334586 ENST00000425015(uc002jqn.2 uc002jqo.2 uc010dgu.2)

ENST00000421794 ENST00000590045 ENST00000392503

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZACN
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ZACN
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZACN OriGene shRNA RFP: ZACN OriGene siRNA: ZACN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZACN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZACN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZACN (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ZACN (NM_180990)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZACN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZACN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZACN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat ZACN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZACN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZACN

Additional cDNA sequence:

AB223030.1 AF512521.1 BC110597.1

6 DOTS entries:

DT.100736899 DT.91763886 DT.427916 DT.217247 DT.100797535 DT.101977811

6 AceView cDNA sequences:

AK122638 NM_180990 AF512521 W05282 AW263938 N75473

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZACN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGGGGCG

About this image

ZACN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ZACN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZACN

SOURCE GeneReport for Unigene cluster: Hs.714919

UniProtKB/Swiss-Prot: ZACN_HUMAN, Q401N2

Tissue specificity: Detected in pancreas, brain, liver, placenta, trachea, kidney, spinal cord, stomach and fetal

brain. In the adult brain region expression is detected in the hippocampus, striatum, amygdala and thalamus

SABiosciences Custom PCR Arrays for ZACN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZACN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat ZACN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZACN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZACN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZACN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZACN gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ZACN⁶	--	41(a)	1 ↔ 1	2(113110404-113116859)
zebrafish (Danio rerio)	Actinopterygii	CABZ01073083.1⁶ BX255960.1⁶	--	19(a) 18(a)	many → 1 many → 1	Zv9_NA542(18368-33152) 3(57216801-57234686)

Species with no ortholog for ZACN

ENSEMBL Gene Tree for ZACN (if available)
TreeFam Gene Tree for ZACN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZACN gene

HTR3E² HTR3A² HTR3C² HTR3D² HTR3B²

ZACN for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ZACN
PGOHUM00000246020

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114366209^1,2	F,	--	74074119(+)	`CTGGCG/ACAAGC`	1	--	us2k¹		1		WA	118
rs2457695^1,2	C,	--	74074196(-)	`GAGTTC/TTACCT`	1	--	us2k¹		12		NA WA CSA EA	374
rs2457694^1,2	F,	--	74074210(-)	`AACCTC/TTGGGA`	1	--	us2k¹		1		EA	120
rs118043954^1,2		--	74074404(+)	`CAGGCG/ATCGAC`	1	--	us2k¹		1		NA	120
rs115519428^1,2	F,	--	74074547(+)	`TTTTGT/CTGTTG`	1	--	us2k¹		1		WA	118
rs186157728^1,2		--	74074587(+)	`AATCTC/TGCTCT`	1	--	us2k¹		0	--	--	--	--
rs140273401^1,2		--	74074625(+)	`AATCTC/TGGCTC`	1	--	us2k¹		0	--	--	--	--
rs189745860^1,2		--	74074636(+)	`ACTGCA/CACCTC`	1	--	us2k¹		0	--	--	--	--
rs145365146^1,2		--	74074710(+)	`CACCAC/TGCCCA`	1	--	us2k¹		0	--	--	--	--
rs181293579^1,2		--	74074793(+)	`AGTCTG/TCCCTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ZACN (74068042 - 74079747 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZACN
1 CNV: 35500

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZACN

DNA2.0 Custom Variant and Variant Library Synthesis for ZACN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZACN for disorders           About GeneDecksing

OMIM gene information: 610935    OMIM disorders: --

12 diseases for ZACN:    About MalaCards

transient neonatal diabetes mellitus neonatal diabetes mellitus long qt syndrome idiopathic generalized epilepsy

generalized epilepsy diabetes mellitus myocardial infarction sinusitis

gastric cancer breast cancer schizophrenia melanoma

1 Novoseek disease relationship for ZACN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
epilepsy	0	2	12752457 (1), 14501839 (1)

Export disorders for ZACN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZACN gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with ZACN)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. (PubMed id 16083862)^{1, 2, 3, 9} Houtani T.... Sugimoto T. (2005)
A novel class of ligand-gated ion channel is activated by Zn2+. (PubMed id 12381728)^{1, 2, 3, 9} Davies P.A.... Kirkness E.F. (2003)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. (PubMed id 15286800)¹ Ma D....Kelsey G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The Seventh Annual Ion Channel Retreat Vancouver, Can ada, June 29-July 1, 2009. (PubMed id 20158438)⁹ Brugger S....King N. (2010)
The sixth annual Ion Channel Retreat Vancouver, Canada, June 23-25, 2008. (PubMed id 19231940)⁹ Choy N....Liang S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 353174	HGNC: 29504	AceView: LGICZ	Ensembl:ENSG00000186919	euGenes: HUgn353174
ECgene: ZACN	H-InvDB: ZACN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZACN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZACN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZACN gene:
Search GeneIP for patents involving ZACN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ZACN
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZACN		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZACN
	OriGene Protein Over-expression Lysate for ZACN		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ZACN		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZACN		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZACN
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ZACN		OriGene Custom Protein Services for ZACN
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZACN
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZACN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZACN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZACN
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZACN
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZACN

	GenScript Custom Purified and Recombinant Proteins Services for ZACN		GenScript cDNA clones with any tag delivered in your preferred vector for ZACN
	GenScript Custom Assay Services for ZACN		GenScript Custom Superior Antibodies Services for ZACN
	GenScript Custom overexpressing Cell Line Services for ZACN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ZACN promoter
	Search Chromatin IP Primers for ZACN
	RT² qPCR Primer Assay in human, mouse / rat ZACN
	Search GNC Networks for ZACN
	SABiosciences Custom PCR Arrays for ZACN

Search Tocris compounds for ZACN

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ZACN antibodies
	ZACN lysates

	Search for Antibodies for ZACN at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ZACN
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ZACN Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ZACN

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZACN

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ZACN
	SwitchGear Promoter luciferase reporter plasmids for ZACN

ThermoFisher Antibodies for ZACN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZACN

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZACN gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ZACN Gene

zinc activated ligand-gated ion channel

Aliases
for ZACN gene

Summaries
for ZACN gene

Genomic Views
for ZACN gene

Proteins
for ZACN gene

Protein Domains /
Families
for ZACN gene

Function
for ZACN gene

Pathways & Interactions
for ZACN gene

Drugs & Compounds
for ZACN gene

Transcripts
for ZACN gene

Expression
for ZACN gene

Orthologs
for ZACN gene

Paralogs
for ZACN gene

Genomic Variants
for ZACN gene

Disorders / Diseases
for ZACN gene

Publications
for ZACN gene

External Searches for ZACN gene

Genome Databases showing ZACN gene

Other Databases showing ZACN gene

Specialized Databases showing ZACN gene

Intellectual Property
for ZACN gene

Products
for ZACN gene

View Random Gene

Advanced Search

Export list of displayed genes

ZACN Gene

zinc activated ligand-gated ion channel

Aliasesfor ZACN gene

Summariesfor ZACN gene

Genomic Viewsfor ZACN gene

Proteinsfor ZACN gene

Protein Domains /Familiesfor ZACN gene

Functionfor ZACN gene

Pathways & Interactionsfor ZACN gene

Drugs & Compoundsfor ZACN gene

Transcriptsfor ZACN gene

Expression for ZACN gene

Orthologsfor ZACN gene

Paralogsfor ZACN gene

Genomic Variantsfor ZACN gene

Disorders / Diseasesfor ZACN gene

Publicationsfor ZACN gene

External Searches for ZACN gene

Genome Databases showing ZACN gene

Other Databases showing ZACN gene

Specialized Databases showing ZACN gene

Intellectual Propertyfor ZACN gene

Productsfor ZACN gene

View Random Gene

Aliases
for ZACN gene

Summaries
for ZACN gene

Genomic Views
for ZACN gene

Proteins
for ZACN gene

Protein Domains /
Families
for ZACN gene

Function
for ZACN gene

Pathways & Interactions
for ZACN gene

Drugs & Compounds
for ZACN gene

Transcripts
for ZACN gene

Expression
for ZACN gene

Orthologs
for ZACN gene

Paralogs
for ZACN gene

Genomic Variants
for ZACN gene

Disorders / Diseases
for ZACN gene

Publications
for ZACN gene

Intellectual Property
for ZACN gene

Products
for ZACN gene