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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YY2 Gene

protein-coding   GIFtS: 44
GCID: GC0XP021874

YY2 Transcription Factor

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
YY2 Transcription Factor1 2     ZNF6312 3
Transcription Factor Yin Yang 21 2     Transcription Factor YY22
Yin And Yang 22 3     YY-23
Zinc Finger Protein 6312 3     

External Ids:    HGNC: 316841   Entrez Gene: 4042812   Ensembl: ENSG000002307977   OMIM: 3005705   UniProtKB: O153913   

Export aliases for YY2 gene to outside databases

Previous GC identifers: GC0XU900516 GC0XP021634 GC0XP021784 GC0XP019615


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YY2 Gene:
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its
C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive
and negative effects on the transcription of target genes. This gene has an intronless coding region, and it
appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on
chromosome 14. (provided by RefSeq, May 2010)

GeneCards Summary for YY2 Gene: 
YY2 (YY2 transcription factor) is a protein-coding gene. Diseases associated with YY2 include genital herpes. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF787.

UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391
Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a
large number of genes. May antagonize YY1 and function in development and differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YY2 gene promoter:
         STAT1   AML1a   NRSF form 1   STAT1beta   IRF-1   Tal-1beta   NRSF form 2   E47   STAT1alpha   FOXC1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for YY2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2-p22.1   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.2-p22.1

YY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YY2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP021874:  view genomic region     (about GC identifiers)

Start:
21,874,105 bp from pter      End:
21,876,845 bp from pter
Size:
2,741 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391 (See protein sequence)
Recommended Name: Transcription factor YY2  
Size: 372 amino acids; 41347 Da
Subcellular location: Nucleus (Probable)
Miscellaneous: The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in
placental mammals. It is encoded by a single exon found in an intron of the gene MBTPS2
Secondary accessions: B2RP10 Q6Q1S4

Explore the universe of human proteins at neXtProt for YY2: NX_O15391

Explore proteomics data for YY2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15391

  • YY2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YY2 Protein Expression
    REFSEQ proteins: NP_996806.2  
    ENSEMBL proteins: 
     ENSP00000389381  

    Human Recombinant Protein Products for YY2: 
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    Cloud-Clone Corp. Proteins for YY2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005886plasma membrane IDA--

    YY2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR017114 TF_Yin_yang
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O15391

    ProtoNet protein and cluster: O15391

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391
    Similarity: Belongs to the YY transcription factor family
    Similarity: Contains 4 C2H2-type zinc fingers


    YY2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYY2_HUMAN, O15391
    Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a
    large number of genes. May antagonize YY1 and function in development and differentiation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    YY2 for ontologies           About GeneDecksing


    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/16 Interacting proteins for YY2 (O153913 ENSP000003893814) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEDO755303, ENSP000002633604I2D: score=1 STRING: ENSP00000263360
    EZH2Q159103I2D: score=2 
    ABCG4Q9H1723I2D: score=1 
    ACTR5Q9H9F93I2D: score=1 
    ACTR8Q9H9813I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0034696response to prostaglandin F stimulus IEA--

    YY2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for YY2 (TYY2)

    Search CenterWatch for drugs/clinical trials and news about YY2 / TYY2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YY2 gene: 
    NM_206923.3  

    Unigene Cluster for YY2:

    YY2 transcription factor
    Hs.673601  [show with all ESTs]
    Unigene Representative Sequence: NM_206923
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000429584(uc011mjp.2)
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate YY2:
    hsa-miR-520d-5p hsa-miR-3143 hsa-miR-4263 hsa-miR-524-5p hsa-miR-548n
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for YY2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YY2
    Clone
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    OriGene clones in human, mouse for YY2 (see all 6)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YY2

    Additional mRNA sequence: 

    AK091850.1 AY567472.1 BC137215.1 BC137217.1 

    1 DOTS entry:

    DT.91699869 

    24/125 AceView cDNA sequences (see all 125):

    AW243699 BX955586 AK056736 Z40075 AA602338 AI206515 BC012905 AW664144 
    CK903672 AF019612 BQ774809 BP377414 CA428609 AI949332 NM_015884 BU623318 
    AA994295 F05287 CB959539 AI015727 CR624755 CF552440 Z44025 BF448656 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGACCAA
    YY2 Expression
    About this image


    See YY2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YY2

    SOURCE GeneReport for Unigene cluster: Hs.673601

    UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391
    Tissue specificity: Expressed in kidney, liver, spleen and testis but not in colon

        SABiosciences Expression via Pathway-Focused PCR Array including YY2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for YY2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yy21 , 5 Yy2 transcription factor1, 5 66.76(n)1
    57.58(a)1
      X (72.57 cM)5
    1000733511  NM_001098723.11  NP_001092193.11 
     1575661195 
    chicken
    (Gallus gallus)
    Aves YY16
    transcriptional repressor protein YY1
    73(a)
    possible ortholog
    5(48418077-48431424)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    73(a)
    possible ortholog
    GL343270.1(988957-993664)
    zebrafish
    (Danio rerio)
    Actinopterygii yy1a6
    yy1b6
    YY1 transcription factor b
    58(a)
    56(a)
    1 ↔ many
    possible ortholog
    17(30916118-30922362)
    20(54760884-54773885)
    fruit fly
    (Drosophila melanogaster)
    Insecta pho6
    phol6
    pleiohomeotic like
    27(a)
    18(a)
    many ↔ many
    many ↔ many
    4(1193094-1202271)
    3L(9446148-9449381)


    ENSEMBL Gene Tree for YY2 (if available)
    TreeFam Gene Tree for YY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YY2 gene
    ZNF7872  ZFP422  ZNF8532  YY12  
    4 SIMAP similar genes for YY2 using alignment to 1 protein entry:     TYY2_HUMAN:
    ZFP42    ZNF    YY1    ZNF323

    YY2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in YY2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0395864
    A breast cancer sample4--see VAR_0395862 D N mis40--------

    HapMap Linkage Disequilibrium report for YY2 (21874105 - 21876845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YY2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740003CNV Deletion23290073


    Locus Specific Mutation Databases (LSDB): YY2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing YY2
    DNA2.0 Custom Variant and Variant Library Synthesis for YY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300570    OMIM disorders: --

    2 diseases for YY2:    About MalaCards
    genital herpes    

    1 disease from the University of Copenhagen DISEASES database for YY2:
    Genital herpes

    YY2 for disorders           About GeneDecksing


    Export disorders for YY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YY2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with YY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Molecular cloning and functional characterization of the transcription factor YY2. (PubMed id 15087442)1, 2, 9 Nguyen N....Seto E. (2004)
    3. Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. (PubMed id 16377127)1, 2 Luo C.... Kim J. (2006)
    4. Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2. (PubMed id 16260628)1, 2 Klar M. and Bode J. (2005)
    5. Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation. (PubMed id 19026728)1, 9 Klar M....Dame C. (2009)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. Association of Rex-1 to target genes supports its inte raction with Polycomb function. (PubMed id 21530438)1 Garcia-Tunon I....Schoorlemmer J. (2011)
    8. Yin Yang 2: the great unknown within the Yin Yang 1 re gulatory network. (PubMed id 22248057)1 Klar M. (2011)
    9. Genome-wide analysis of YY2 versus YY1 target genes. (PubMed id 20215434)1 Chen L....Schmidt E.V. (2010)
    10. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 404281 HGNC: 31684 AceView: MBTPS2 Ensembl:ENSG00000230797 euGenes: HUgn404281
    ECgene: YY2 H-InvDB: YY2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YY2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YY2 gene:
    Search GeneIP for patents involving YY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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