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Aliases for YY2 Gene

Aliases for YY2 Gene

  • YY2 Transcription Factor 2 3 5
  • Transcription Factor Yin Yang 2 2 3
  • Zinc Finger Protein 631 3 4
  • Yin And Yang 2 3 4
  • ZNF631 3 4
  • YY-2 4

External Ids for YY2 Gene

Previous GeneCards Identifiers for YY2 Gene

  • GC0XU900516
  • GC0XP021634
  • GC0XP021784
  • GC0XP019615
  • GC0XP021874

Summaries for YY2 Gene

Entrez Gene Summary for YY2 Gene

  • The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]

GeneCards Summary for YY2 Gene

YY2 (YY2 Transcription Factor) is a Protein Coding gene. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for YY2 Gene

  • Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YY2 Gene

Genomics for YY2 Gene

Regulatory Elements for YY2 Gene

Genomic Location for YY2 Gene

Chromosome:
X
Start:
21,855,987 bp from pter
End:
21,858,727 bp from pter
Size:
2,741 bases
Orientation:
Plus strand

Genomic View for YY2 Gene

Genes around YY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YY2 Gene

Proteins for YY2 Gene

  • Protein details for YY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15391-TYY2_HUMAN
    Recommended name:
    Transcription factor YY2
    Protein Accession:
    O15391
    Secondary Accessions:
    • B2RP10
    • Q6Q1S4

    Protein attributes for YY2 Gene

    Size:
    372 amino acids
    Molecular mass:
    41347 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene MBTPS2.

neXtProt entry for YY2 Gene

Proteomics data for YY2 Gene at MOPED

Post-translational modifications for YY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for YY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for YY2 Gene

Domains & Families for YY2 Gene

Gene Families for YY2 Gene

Protein Domains for YY2 Gene

Suggested Antigen Peptide Sequences for YY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15391

UniProtKB/Swiss-Prot:

TYY2_HUMAN :
  • Belongs to the YY transcription factor family.
  • Contains 4 C2H2-type zinc fingers.
Family:
  • Belongs to the YY transcription factor family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with YY2: view

Function for YY2 Gene

Molecular function for YY2 Gene

UniProtKB/Swiss-Prot Function:
Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.

Gene Ontology (GO) - Molecular Function for YY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042826 histone deacetylase binding IEA --
genes like me logo Genes that share ontologies with YY2: view
genes like me logo Genes that share phenotypes with YY2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YY2 Gene

Localization for YY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YY2 Gene COMPARTMENTS Subcellular localization image for YY2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for YY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with YY2: view

Pathways & Interactions for YY2 Gene

SuperPathways for YY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with YY2: view

No data available for Pathways by source and SIGNOR curated interactions for YY2 Gene

Drugs & Compounds for YY2 Gene

No Compound Related Data Available

Transcripts for YY2 Gene

mRNA/cDNA for YY2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YY2 Gene

YY2 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YY2 Gene

No ASD Table

Relevant External Links for YY2 Gene

GeneLoc Exon Structure for
YY2
ECgene alternative splicing isoforms for
YY2

Expression for YY2 Gene

mRNA expression in normal human tissues for YY2 Gene

Protein differential expression in normal tissues from HIPED for YY2 Gene

This gene is overexpressed in CD8 Tcells (22.9), Placenta (13.7), NK cells (12.7), Testis (8.3), and Blymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YY2 Gene



SOURCE GeneReport for Unigene cluster for YY2 Gene Hs.673601

mRNA Expression by UniProt/SwissProt for YY2 Gene

O15391-TYY2_HUMAN
Tissue specificity: Expressed in kidney, liver, spleen and testis but not in colon.
genes like me logo Genes that share expression patterns with YY2: view

Protein tissue co-expression partners for YY2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for YY2 Gene

Orthologs for YY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for YY2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC102152457 35
  • 75.05 (n)
  • 65.3 (a)
mouse
(Mus musculus)
Mammalia Yy2 35
  • 66.48 (n)
  • 57.3 (a)
Yy2 16
Yy2 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YY2 35
  • 98.84 (n)
  • 98.12 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves YY1 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii yy1a 36
  • 57 (a)
ManyToMany
yy1b 36
  • 54 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta pho 36
  • 27 (a)
ManyToMany
phol 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for YY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YY2 Gene

ENSEMBL:
Gene Tree for YY2 (if available)
TreeFam:
Gene Tree for YY2 (if available)

Paralogs for YY2 Gene

(4) SIMAP similar genes for YY2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with YY2: view

Variants for YY2 Gene

Sequence variations from dbSNP and Humsavar for YY2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_039586 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for YY2 Gene

Variant ID Type Subtype PubMed ID
esv2740003 CNV Deletion 23290073

Variation tolerance for YY2 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YY2 Gene

HapMap Linkage Disequilibrium report
YY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YY2 Gene

Disorders for YY2 Gene

Relevant External Links for YY2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YY2

No disorders were found for YY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YY2 Gene

Publications for YY2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation. (PMID: 19026728) Klar M. … Dame C. (Gene 2009) 3 23
  3. Molecular cloning and functional characterization of the transcription factor YY2. (PMID: 15087442) Nguyen N. … Seto E. (J. Biol. Chem. 2004) 3 23
  4. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  5. Association of Rex-1 to target genes supports its interaction with Polycomb function. (PMID: 21530438) Garcia-TuA+on I. … Schoorlemmer J. (Stem Cell Res 2011) 3

Products for YY2 Gene

Sources for YY2 Gene

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