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Aliases &
Descriptions
for YY2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| OTTHUMP00000023045 2 | | YY-2 3 | | ZNF631 1, 2, 3 |
| | | Descriptions |
|---|
| YY2 transcription factor 2 | | Yin and yang 2 3 | | Zinc finger protein 631 3 | | transcription factor yin yang 2 2 |
|
| |
Search outside databases for aliases for YY2 genePrevious GC identifers: GC0XU900516 GC0XP021634 |
Summaries
for YY2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Function: Functions as a multifunctional transcription factor that may exhibit positive and
negative control on a large number of genes. May antagonize YY1 and function in development and
differentiation |
Genomic Location
for YY2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the YY2 gene 
Entrez Gene cytogenetic band: Xp22.2-p22.1 Ensembl cytogenetic band: Xp22.12 HGNC cytogenetic band: Xp22.2-p22.1YY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP021784:
(about GC identifiers)
Start:
|
21,784,026 bp from pter |
End:
|
21,786,766 bp from pter |
Size:
|
2,741 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011757.15
| Proteins
for YY2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391 (See
protein sequence)Recommended Name: Transcription factor YY2 Size: 372 amino acids; 41347 Da
Subcellular location: Nucleus (Probable)
Miscellaneous: The gene encoding this protein appears to have arisen by retrotransposition of the
YY1 gene in placental mammals. It is encoded by a single exon found in an intron of the gene
MBTPS2
Secondary accessions: Q6Q1S4Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_996806.2
ENSEMBL proteins: ENSP00000355023
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for YY2:
Assays for YY2: | Protein
Domains/
Families
for YY2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15391
ProtoNet protein and cluster: O15391 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Similarity: Belongs to the YY transcription factor familySimilarity: Contains 4 C2H2-type zinc fingers | Gene Function
for YY2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_206923
 Applied Biosystems Silencer® siRNAs for YY2
 Sigma-Aldrich siRNA for YY2
Sigma-Aldrich shRNA for YY2
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_206923
Myc/DDK tagged cDNA clone in CMV expression vector: NM_206923
untagged cDNA clone in CMV expression vector: NM_206923
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_206923
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Function: Functions as a multifunctional transcription factor that may exhibit positive and
negative control on a large number of genes. May antagonize YY1 and function in development and
differentiation3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions
for YY2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
--2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
About this table
|
Drugs & Compounds
for YY2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for YY2
|
Transcripts
for YY2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_206923
Sigma-Aldrich siRNA for YY2
Sigma-Aldrich shRNA for YY2
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_206923 REFSEQ mRNAs for YY2 gene: NM_206923.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_206923
OriGene GFP tagged cDNA clone in CMV expression vector: NM_206923
Myc/DDK tagged cDNA clone in CMV expression vector: NM_206923
untagged cDNA clone in CMV expression vector: NM_206923
Additional cDNA sequence: AK091850.1 AY567472.1 BC137215.1 BC137217.1 1 DOTS entry: DT.91699869 24/125 AceView cDNA sequences (see all 125
):AA994295 NM_015884 CA428609 CK903672 BP377414 Z38312 AF019612 AW243699 CB959539 F05287 CF552440 BQ774809 BF448656 Z40075 Z44025 AU130756 BX955586 CR624755 BU623318 AI015727 BI963704 AI949332 AK056736 BC012905
 highest scoring ESTs for YY2:BE077380 BQ082465 BC012905 BI560279 AY567472 BX955529 AK091850 NM_206923 AU120901 BX472669 Unigene Cluster for YY2: YY2 transcription factor Hs.673601 [show with all ESTs]Unigene Representative Sequence: AK091850
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000361929
|
Expression
for YY2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| YY2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for YY2
1 / 2 / 3 2 probe-sets matching YY2 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGAAGACCAA
SOURCE GeneReport for Unigene cluster: Hs.673601
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Tissue specificity: Expressed in kidney, liver, spleen and testis but not in colon |
Orthologs
for YY2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for YY2 gene from 2 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
YY21 |
-- |
YY2 transcription factor |
98.84(n)
98.12(a) |
473861 XM_529235.2 XP_529235.2 |
mouse
(Mus musculus) |
Yy25 |
X |
Yy2 transcription factor |
-- |
EF688658 |
About this table Species with no ortholog for YY2
ENSEMBL Gene Tree for YY2 | Paralogs
for YY2(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for YY2 gene
- ZFP422 GLI12 YY12
|
SNPs/Variants
for YY2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for YY2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300570
|
Medical News
for YY2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for YY2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 9 PubMed articles for YY2 gene: |
Search for YY2
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YY2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing YY2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YY2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for YY2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for YY2:
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