YY2 Gene
protein-coding GIFtS: 41
GCID: GC0XP021874
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YY2 transcription factor
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Aliases
for YY2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| YY2 Transcription Factor1 2 | | Transcription Factor Yin Yang 22 | | ZNF6311 2 3 | | Transcription Factor YY22 | | Yin And Yang 22 3 | | YY-23 | | Zinc Finger Protein 6312 3 | | |
Export aliases for YY2 gene to outside databasesPrevious GC identifers: GC0XU900516 GC0XP021634 GC0XP021784 GC0XP019615 |
Summaries
for YY2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for YY2:
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in itsC-terminal region. It possesses both activation and repression domains, and it can therefore have both positive andnegative effects on the transcription of target genes. This gene has an intronless coding region, and it appears tohave arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14.(provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a largenumber of genes. May antagonize YY1 and function in development and differentiation
|
Genomic Views
for YY2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the YY2 gene promoter:
STAT1 AML1a NRSF form 1 STAT1beta IRF-1 Tal-1beta NRSF form 2 E47 STAT1alpha FOXC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for YY2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YY2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.2-p22.1 Ensembl cytogenetic band: Xp22.12 HGNC cytogenetic band: Xp22.2-p22.1YY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP021874: view genomic region
(about GC identifiers)
Start:
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21,874,105 bp from pter |
End:
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21,876,845 bp from pter |
Size:
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2,741 bases |
Orientation:
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plus strand |
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Proteins
for YY2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391 (See
protein sequence)Recommended Name: Transcription factor YY2 Size: 372 amino acids; 41347 Da
Subcellular location: Nucleus (Probable)
Miscellaneous: The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placentalmammals. It is encoded by a single exon found in an intron of the gene MBTPS2
Secondary accessions: B2RP10 Q6Q1S4Explore the universe of human proteins at neXtProt for YY2: NX_O15391
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15391
YY2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_996806.2
ENSEMBL proteins: ENSP00000389381
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
YY2 for ontologies About GeneDecksing
YY2 Antibody Products:
Assay Products for YY2: |
Protein
Domains /
Families
for YY2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
YY2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15391ProtoNet protein and cluster: O15391 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Similarity: Belongs to the YY transcription factor familySimilarity: Contains 4 C2H2-type zinc fingers |
Function
for YY2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a largenumber of genes. May antagonize YY1 and function in development and differentiation
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
YY2 for ontologies About GeneDecksing
|
Pathways & Interactions
for YY2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for YY2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/16 Interacting proteins for YY2 (O153913 ENSP000003893814) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
YY2 for ontologies About GeneDecksing
|
Drugs & Compounds
for YY2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for YY2
Search CenterWatch for drugs/clinical trials and news about YY2 / TYY2
|
Transcripts
for YY2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for YY2 gene: NM_206923.3 Unigene Cluster for YY2: YY2 transcription factor Hs.673601 [show with all ESTs]Unigene Representative Sequence: NM_2069231 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000429584(uc011mjp.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YY2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for YY2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for YY2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YY2 |
Additional cDNA sequence: AK091850.1 AY567472.1 BC137215.1 BC137217.1 1 DOTS entry: DT.91699869 24/125 AceView cDNA sequences (see all 125): CB959539 AA602338 Z40075 AI015727 CF552440 AI949332 BU623318 AI206515 BF448656 AF019612 AW664144 F05287 BI963704 BP377414 AU130756 AA994295 BX955586 CK903672 BX955067 CR624755 BQ774809 BC012905 AW243699 NM_015884
GeneLoc Exon Structure
|
Expression
for YY2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| YY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGACCAA
About this image
See YY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YY2
SOURCE GeneReport for Unigene cluster: Hs.673601
UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391Tissue specificity: Expressed in kidney, liver, spleen and testis but not in colon
SABiosciences Expression via Pathway-Focused PCR Array including YY2: | Polycomb & Trithorax Complexes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YY2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY2 |
Orthologs
for YY2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for YY2 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
yy1b6 |
YY1 transcription factor b |
55(a) |
1 ↔ 1 |
20(54760884-54773885) |
fruit fly
(Drosophila melanogaster) |
Insecta |
pho6phol6 |
pleiohomeotic like |
27(a)18(a) |
possible ortholog1 ↔ many |
4(1193094-1202271) 3L(9446148-9449381) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G066346 |
uncharacterized zinc finger protein |
16(a) |
1 → many |
4(3764289-3766578) |
rice
(Oryza sativa) |
Liliopsida |
---- |
ZOS5-01 - C2H2 zinc finger protein, expressed |
19(a)15(a) |
many ↔ manymany ↔ many |
2(20795085-20798606) 5(321102-324421) |
ENSEMBL Gene Tree for YY2 (if available)
TreeFam Gene Tree for YY2 (if available) |
Paralogs
for YY2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for YY2 gene
- MTF12 ZIC32 ZNF762 ZNF4102 GLI12 ZIC22 YY12 ZIC12
- GLIS22 GLI22 ZIC42 GLIS12 ZFP422 ZNF1432 GLIS32 ZIC52
- GLI32
4 SIMAP similar genes for YY2 using alignment to 1 protein entry: TYY2_HUMAN:ZFP42 ZNF YY1 ZNF323
YY2 for paralogs About GeneDecksing
|
Genomic Variants
for YY2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Locus Specific Mutation Databases (LSDB): YY2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YY2 |
|
Disorders
/ Diseases
for YY2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
YY2 for disorders About GeneDecksing
OMIM gene information: 300570
OMIM disorders: --
2  diseases for YY2: About MalaCardsgenital herpes metastasis efficiency
1 disease from the University of Copenhagen DISEASES database for YY2:Genital herpes Export disorders for YY2 gene to outside databases
|
Publications
for YY2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for YY2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with YY2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
- Molecular cloning and functional characterization of the transcription factor YY2. (PubMed id 15087442)1, 2, 9 Nguyen N....Seto E. (2004)
- Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. (PubMed id 16377127)1, 2 Luo C.... Kim J. (2006)
- Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2. (PubMed id 16260628)1, 2 Klar M. and Bode J. (2005)
- Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation. (PubMed id 19026728)1, 9 Klar M....Dame C. (2009)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Association of Rex-1 to target genes supports its inte raction with Polycomb function. (PubMed id 21530438)1 Garcia-Tunon I....Schoorlemmer J. (2011)
- Yin Yang 2: the great unknown within the Yin Yang 1 re gulatory network. (PubMed id 22248057)1 Klar M. (2011)
- Genome-wide analysis of YY2 versus YY1 target genes. (PubMed id 20215434)1 Chen L....Schmidt E.V. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
|
External Searches for YY2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing YY2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing YY2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing YY2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for YY2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for YY2 gene:
Search GeneIP for patents involving YY2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for YY2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY2 |
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