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YY2 Gene

protein-coding   GIFtS: 41
GCID: GC0XP021874

YY2 Transcription Factor

  See YY2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YY2 Transcription Factor1 2     Zinc Finger Protein 6312 3
ZNF6312 3 5     Transcription Factor YY22
Transcription Factor Yin Yang 21 2     YY-23
Yin And Yang 22 3     

External Ids:    HGNC: 316841   Entrez Gene: 4042812   Ensembl: ENSG000002307977   OMIM: 3005705   UniProtKB: O153913   

Export aliases for YY2 gene to outside databases

Previous GC identifers: GC0XU900516 GC0XP021634 GC0XP021784 GC0XP019615


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YY2 Gene:
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its
C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive
and negative effects on the transcription of target genes. This gene has an intronless coding region, and it
appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on
chromosome 14. (provided by RefSeq, May 2010)

GeneCards Summary for YY2 Gene:
YY2 (YY2 transcription factor) is a protein-coding gene. Diseases associated with YY2 include genital herpes, and breast and colorectal cancer. An important paralog of this gene is ZNF787.

UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391
Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a
large number of genes. May antagonize YY1 and function in development and differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the YY2 gene promoter:
         STAT1   AML1a   NRSF form 1   STAT1beta   IRF-1   Tal-1beta   NRSF form 2   E47   STAT1alpha   FOXC1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for YY2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2-p22.1   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.2-p22.1

YY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YY2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP021874:  view genomic region     (about GC identifiers)

Start:
21,874,105 bp from pter      End:
21,876,845 bp from pter
Size:
2,741 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391 (See protein sequence)
Recommended Name: Transcription factor YY2  
Size: 372 amino acids; 41347 Da
Miscellaneous: The gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in
placental mammals. It is encoded by a single exon found in an intron of the gene MBTPS2
Secondary accessions: B2RP10 Q6Q1S4

Explore the universe of human proteins at neXtProt for YY2: NX_O15391

Explore proteomics data for YY2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See YY2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_996806.2  
    ENSEMBL proteins: 
     ENSP00000389381  

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    antibodies-online peptides for YY2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR017114 TF_Yin_yang
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O15391

    ProtoNet protein and cluster: O15391

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391
    Similarity: Belongs to the YY transcription factor family
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with YY2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYY2_HUMAN, O15391
    Function: Functions as a multifunctional transcription factor that may exhibit positive and negative control on a
    large number of genes. May antagonize YY1 and function in development and differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with YY2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for YY2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYY2_HUMAN, O15391: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex ----
    GO:0005886plasma membrane ----

    Find genes that share ontologies with YY2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including YY2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for YY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YY2 (O153913 ENSP000003893814) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHHO433233, ENSP000002669914I2D: score=1 STRING: ENSP00000266991
    EEDO755303, ENSP000002633604I2D: score=1 STRING: ENSP00000263360
    ABCG4Q9H1723, ENSP000003041114I2D: score=1 STRING: ENSP00000304111
    EZH2Q159103I2D: score=2 
    ACTR5Q9H9F93I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0034696response to prostaglandin F ----

    Find genes that share ontologies with YY2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for YY2 (TYY2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YY2 gene: 
    NM_206923.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000429584(uc011mjp.2)
    miRNA
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat YY2

    Selected AceView cDNA sequences (see all 125):

    AW243699 CA428609 AK056736 BI963704 NM_015884 AI015727 F05287 AI206515 
    AW664144 CB959539 BF448656 CR624755 CF552440 BQ774809 BX955067 Z38312 
    AF019612 BP377414 BC012905 AU130756 CK903672 AI949332 Z40075 AA602338 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGACCAA
    YY2 Expression
    About this image

    YY2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YY2 Protein Expression

    UniProtKB/Swiss-Prot: TYY2_HUMAN, O15391
    Tissue specificity: Expressed in kidney, liver, spleen and testis but not in colon

        Pathway & Disease-focused RT2 Profiler PCR Array including YY2: 
              Polycomb & Trithorax Complexes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YY2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yy21 , 5 Yy2 transcription factor1, 5 66.48(n)1
    57.3(a)1
      X (72.57 cM)5
    1000733511  NM_001098723.11  NP_001092193.11 
     1575661195 
    chicken
    (Gallus gallus)
    Aves YY16
    Gallus gallus YY1 transcription factor (YY1), mRNA...
    72(a)
    1 → many
    5(48418077-48431424)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    72(a)
    1 → many
    GL343270.1(988957-993664)
    zebrafish
    (Danio rerio)
    Actinopterygii yy1a6
    yy1b6
    YY1 transcription factor b
    57(a)
    54(a)
    many ↔ many
    many ↔ many
    17(30916118-30922362) ENSDARG00000042796
    20(54760868-54773885) ENSDARG00000027978
    fruit fly
    (Drosophila melanogaster)
    Insecta pho6
    phol6
    pleiohomeotic like
    27(a)
    19(a)
    many ↔ many
    many ↔ many
    4(1193094-1202271)
    3L(9446148-9449381)


    ENSEMBL Gene Tree for YY2 (if available)
    TreeFam Gene Tree for YY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YY2 gene
    ZNF7872  ZFP422  ZNF8532  YY12  
    4 SIMAP similar genes for YY2 using alignment to 1 protein entry:     TYY2_HUMAN:
    ZFP42    ZNF    YY1    ZNF323

    Find genes that share paralogs with YY2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for YY2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0395864
    A breast cancer sample4--see VAR_0395862 D N mis40--------

    HapMap Linkage Disequilibrium report for YY2 (21874105 - 21876845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YY2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740003CNV Deletion23290073

    Locus Specific Mutation Databases (LSDB): YY2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YY2
    DNA2.0 Custom Variant and Variant Library Synthesis for YY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300570    OMIM disorders: --

    2 diseases for YY2:    
    About MalaCards
    genital herpes    breast and colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for YY2:
    Genital herpes

    Find genes that share disorders with YY2           About GenesLikeMe


    Export disorders for YY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YY2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with YY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Molecular cloning and functional characterization of the transcription factor YY2. (PubMed id 15087442)1, 2, 9 Nguyen N.... Seto E. (J. Biol. Chem. 2004)
    3. Rapid evolution of a recently retroposed transcription factor YY2 in mammalian genomes. (PubMed id 16377127)1, 2 Luo C.... Kim J. (Genomics 2006)
    4. Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2. (PubMed id 16260628)1, 2 Klar M. and Bode J. (Mol. Cell. Biol. 2005)
    5. Transcriptional activity of the novel identified human yy2 promoter is modified by DNA methylation. (PubMed id 19026728)1, 9 Klar M....Dame C. (Gene 2009)
    6. Association of Rex-1 to target genes supports its interaction with Polycomb function. (PubMed id 21530438)1 Garcia-TuA+on I....Schoorlemmer J. (Stem Cell Res 2011)
    7. Yin Yang 2: the great unknown within the Yin Yang 1 regulatory network. (PubMed id 22248057)1 Klar M. (Crit Rev Oncog 2011)
    8. Genome-wide analysis of YY2 versus YY1 target genes. (PubMed id 20215434)1 Chen L....Schmidt E.V. (Nucleic Acids Res. 2010)
    9. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    10. The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. (PubMed id 19710015)1 Crawford N.P....Hunter K.W. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 404281 HGNC: 31684 AceView: MBTPS2 Ensembl:ENSG00000230797 euGenes: HUgn404281
    ECgene: YY2 H-InvDB: YY2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YY2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YY2 gene:
    Search GeneIP for patents involving YY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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