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YY1AP1 Gene

protein-coding   GIFtS: 53
GCID: GC01M155630

YY1 Associated Protein 1

  See YY1AP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YY1 Associated Protein 11 2     YY1AP2 3
Hepatocellular Carcinoma Susceptibility Protein2 3     HCCA12
Hepatocellular Carcinoma-Associated Protein 22 3     YAP2
HCCA22 3     YY1-Associated Protein 12

External Ids:    HGNC: 309351   Entrez Gene: 552492   Ensembl: ENSG000001633747   OMIM: 6078605   UniProtKB: Q9H8693   

Export aliases for YY1AP1 gene to outside databases

Previous GC identifers: GC01M152444 GC01M153895 GC01M126991


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YY1AP1 Gene:
The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Jul 2008)

GeneCards Summary for YY1AP1 Gene:
YY1AP1 (YY1 associated protein 1) is a protein-coding gene. Diseases associated with YY1AP1 include hepatocellular carcinoma. An important paralog of this gene is GON4L.

UniProtKB/Swiss-Prot: YYAP1_HUMAN, Q9H869
Function: Enhances transcription activation by YY1. May play a role in cell cycle regulation

Gene Wiki entry for YY1AP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the YY1AP1 gene promoter:
         GR   GR-alpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYY1AP1 promoter sequence
   Search Chromatin IP Primers for YY1AP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YY1AP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

YY1AP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YY1AP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155630:  view genomic region     (about GC identifiers)

Start:
155,629,233 bp from pter      End:
155,658,823 bp from pter
Size:
29,591 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: YYAP1_HUMAN, Q9H869 (See protein sequence)
Recommended Name: YY1-associated protein 1  
Size: 796 amino acids; 87944 Da
Subunit: Interacts with YY1. Interacts with MAD2L2
Sequence caution: Sequence=BAA91871.1; Type=Erroneous initiation;
Secondary accessions: B0QZ54 B4DMP2 B4E0I0 D3DV96 D3DV98 H7BY62 Q5VYZ1 Q5VYZ4 Q5VYZ7 Q7L4C3
Q7L5E2 Q8IXA6 Q8TEW5 Q8TF04 Q96HB6 Q9BQ64 Q9NV84
Alternative splicing: 9 isoforms:  Q9H869-1   Q9H869-2   Q9H869-3   Q9H869-4   Q9H869-5   Q9H869-6   Q9H869-7   Q9H869-8   
Q9H869-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YY1AP1: NX_Q9H869

Explore proteomics data for YY1AP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See YY1AP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (12 alternative transcripts): 
    NP_620830.1  NP_001185828.1  NP_001185829.1  NP_001185830.1  NP_001185831.1  NP_001185832.1  NP_001185833.1  NP_001185834.1  
    NP_001185835.1  NP_060723.2  NP_620829.1  NP_620832.1  

    ENSEMBL proteins: 
     ENSP00000311138   ENSP00000357324   ENSP00000346722   ENSP00000316079   ENSP00000355298  
     ENSP00000347686   ENSP00000354716   ENSP00000385390   ENSP00000352134   ENSP00000385791  
     ENSP00000390116   ENSP00000295566   ENSP00000357314   ENSP00000384583   ENSP00000409203  
     ENSP00000413240   ENSP00000357323   ENSP00000437926   ENSP00000387590  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9H869


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: YYAP1_HUMAN, Q9H869
    Function: Enhances transcription activation by YY1. May play a role in cell cycle regulation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
         
    Find genes that share ontologies with YY1AP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for YY1AP1:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YY1AP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YY1AP1
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    miRNA
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    hsa-mir-375 (MIRT004478), hsa-mir-222-3p (MIRT046762)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    YYAP1_HUMAN, Q9H869: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17541814
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with YY1AP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including YY1AP1: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YY1AP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for YY1AP1 (Q9H8691, 2, 3 ENSP000002955664) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 3, ENSP000002447694EBI-946122,EBI-930964 I2D: score=2 STRING: ENSP00000244769
    MAPK8IP2Q133872, 3MINT-8262693 I2D: score=2 
    DMRTC1Q5HYR23I2D: score=1 
    DMRTC1BQ5HYR23I2D: score=1 
    MAPK14Q165393, ENSP000002297944I2D: score=3 STRING: ENSP00000229794
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0051726regulation of cell cycle IDA17541814

    Find genes that share ontologies with YY1AP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YY1AP1 (YYAP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YY1AP1 gene (13 alternative transcripts): 
    NM_139119.2  NM_139120.1  NM_001198899.1  NM_001198900.1  NM_001198901.1  NM_001198902.1  NM_001198903.1  NM_001198904.1  
    NM_001198905.1  NM_001198906.1  NM_018253.3  NM_139118.2  NM_139121.2  

    Unigene Cluster for YY1AP1:

    YY1 associated protein 1
    Hs.584927  [show with all ESTs]
    Unigene Representative Sequence: NM_001198903
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000442834 ENST00000311573 ENST00000368340(uc009wqt.3 uc001flh.3 uc010pgi.2 uc010pgk.2)
    ENST00000354691 ENST00000347088(uc010pgg.2 uc010pgh.2 uc021paz.1)
    ENST00000361831(uc001flk.3) ENST00000355499 ENST00000361140(uc001fll.3 uc009wqu.3 uc009wqv.3 uc001fli.3)
    ENST00000404643 ENST00000359205(uc001flm.3) ENST00000407221(uc009wqw.3 uc001flj.3)
    ENST00000436865(uc001flo.3) ENST00000295566(uc001fln.3 uc010pgj.2)
    ENST00000368330(uc001flp.3) ENST00000405763(uc009wqx.3) ENST00000488784
    ENST00000493625 ENST00000477470
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat YY1AP1
      QuantiFast Probe-based Assays in human, mouse, rat YY1AP1

    Additional mRNA sequence: 

    AF466401.1 AK001737.1 AK023976.1 AK125590.1 AK225883.1 AK297562.1 AK298904.1 AK303046.1 
    AK303386.1 AK303944.1 AK309701.1 AY604179.1 BC001655.2 BC001843.2 BC003500.1 BC008766.2 
    BC009358.2 BC014906.2 BC025272.1 BC044887.1 CR749789.1 

    Selected DOTS entries (see all 48):

    DT.100038088  DT.91775860  DT.100884357  DT.92400830  DT.100884359  DT.451937  DT.95306306  DT.100884358 
    DT.95193917  DT.91775856  DT.100884346  DT.100884352  DT.95120355  DT.91861896  DT.95148758  DT.95148764 
    DT.100884355  DT.92418330  DT.100884345  DT.95148784  DT.100884353  DT.91904904  DT.97863082  DT.100038083 

    Selected AceView cDNA sequences (see all 641):

    BQ026343 BC003500 AW248050 BM830203 BU517143 BQ961966 CF125250 BX423899 
    AK023976 BC014906 BQ067834 AF466401 BM907800 NM_139118 BM975479 CA426111 
    BQ057130 BF431856 CR622167 AI435075 AA454147 AA765855 AU280465 BQ065651 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YY1AP1 (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ·
    SP1:                                      -                                   -                       -     -                                                   
    SP2:                                -     -                 -                 -                       -     -                                                   
    SP3:                                                        -                 -                       -     -                                                   
    SP4:        -     -     -     -     -     -                 -                 -                       -     -                                                   
    SP5:                                -     -                 -                 -                                                                                 

    ExUns: 14d · 14e ^ 15 ^ 16 ^ 17a · 17b ^ 18
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for YY1AP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YY1AP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTGGACA
    YY1AP1 Expression
    About this image


    YY1AP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Testis (Reproductive System)
    YY1AP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YY1AP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584927

    UniProtKB/Swiss-Prot: YYAP1_HUMAN, Q9H869
    Tissue specificity: Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach,
    spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Array including YY1AP1: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY1AP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YY1AP1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    21(a)
    1 → many
    25(1435904-1456763)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    22(a)
    1 → many
    GL343519.1(376803-418918)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-27c15.36
    si:dkey-27c15.3
    12(a)
    many ↔ many
    19(27167479-27209034) ENSDARG00000056847
    fruit fly
    (Drosophila melanogaster)
    Insecta mute6
    muscle wasted
    7(a)
    1 → many
    2R(12835802-12842770)
            Species with no ortholog for YY1AP1

    ENSEMBL Gene Tree for YY1AP1 (if available)
    TreeFam Gene Tree for YY1AP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YY1AP1 gene
    GON4L2  
    2 SIMAP similar genes for YY1AP1 using alignment to 8 protein entries:     YYAP1_HUMAN (see all proteins):
    DKFZp686J14104    GON4L

    Find genes that share paralogs with YY1AP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YY1AP1 (see all 595)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500836241,2
    --155628844(+) CCAAAA/CTGGGT 12 -- ds5001 int10--------
    rs746615201,2
    C,F--155629042(+) CATGCC/TGAAAA 12 -- ds5001 int11Minor allele frequency- T:0.03WA 118
    rs412642431,2
    C,F--155629116(+) GCACCG/ACAATT 12 -- ds5001 int12Minor allele frequency- A:0.07NA 122
    rs1488490211,2
    --155629203(+) GAATGC/TTGAAT 12 -- ds5001 int10--------
    rs1815137751,2
    C--155629269(+) ATTTAC/TTGAAG 12 -- ut310--------
    rs1160241911,2
    C,F--155629386(+) ACCCTA/GTGCGC 12 -- ut311Minor allele frequency- G:0.05WA 118
    rs1435181601,2
    C,F--155629451(+) GCTCAA/GAGAAA 23 L syn1 ut311Minor allele frequency- G:0.00NA 4544
    rs75391,2,,4
    C,F,O,H--155629483(-) AACCTG/CAAGAT 23 /Q /E mis1 ut31 ese323Minor allele frequency- C:0.02NS MN NA EA EU 7515
    rs2008167381,2
    --155629500(+) TGACAA/GCTTCC 23 A V mis1 ut310--------
    rs1857135471,2
    C--155629580(+) CTTCCC/TTCCTC 23 E syn1 ut310--------

    HapMap Linkage Disequilibrium report for YY1AP1 (155629233 - 155658823 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for YY1AP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718429CNV Deletion23290073
    nsv436522CNV Deletion17901297
    esv2718418CNV Deletion23290073
    nsv3054CNV Loss18451855
    esv33869CNV Loss17666407
    nsv428246CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YY1AP1
    DNA2.0 Custom Variant and Variant Library Synthesis for YY1AP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607860    OMIM disorders: --

    1 disease for YY1AP1:    
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    hepatocellular carcinoma


    Find genes that share disorders with YY1AP1           About GenesLikeMe

    Genetic Association Database (GAD): YY1AP1

    Export disorders for YY1AP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YY1AP1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with YY1AP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel human hepatocellular carcinoma-associated gene. (PubMed id 11710830)1, 2, 3, 9 Wang Z.-X.... Wu M.-C. (Br. J. Cancer Suppl. 2001)
    2. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. (PubMed id 17541814)1, 2, 9 Li L.... Huo K. (Mol. Cell. Biochem. 2007)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. YY1AP, a novel co-activator of YY1. (PubMed id 14744866)1, 2 Wang C.-Y.... Yu W.C.Y. (J. Biol. Chem. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma. (PubMed id 12118372)1, 2 Zeng J.Z.... Wu M.-C. (Oncogene 2002)
    8. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. (PubMed id 23954413)1 Aragona M....Piccolo S. (Cell 2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene. (PubMed id 23450633)1 ReguAc L....Avruch J. (Bioessays 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55249 HGNC: 30935 AceView: YAP Ensembl:ENSG00000163374 euGenes: HUgn55249
    ECgene: YY1AP1 H-InvDB: YY1AP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YY1AP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YY1AP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YY1AP1 gene:
    Search GeneIP for patents involving YY1AP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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