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Aliases & Descriptions for YY1AP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ10875 2 FLJ13914 2 HCCA1 2 HCCA2 1 , 2 , 3 OTTHUMP00000033474 2 OTTHUMP00000033476 2 OTTHUMP00000033479 2 OTTHUMP00000060027 2 YAP 1 , 2 YY1AP 1 , 2 , 3
Descriptions Hepatocellular carcinoma susceptibility protein 2 , 3 Hepatocellular carcinoma-associated protein 2 2 , 3 YY1 associated protein 1 2 YY1-associated protein 2
Search outside databases for aliases for YY1AP1 genePrevious GC identifer: GC01M152444
Summaries for YY1AP1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for YY1AP1 : The encoded gene product presumably interacts with YY1 protein; however, its exact function is notknown. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq] UniProtKB/Swiss-Prot: YYAP1_HUMAN, Q9H869 Function : Enhances transcription activation by YY1
Gene Wiki entry for YY1AP1
Genomic Location for YY1AP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the YY1AP1 gene Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22 YY1AP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M153895:
(about GC identifiers )
Start:
153,895,857 bp from pter
End:
153,925,415 bp from pter
Size:
29,559 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for YY1AP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: YYAP1_HUMAN, Q9H869 (See
protein sequence )Recommended Name: YY1-associated protein 1 Size : 796 amino acids; 87944 Da
Subunit : Interacts with YY1
Subcellular location : Cytoplasm. Nucleus
Secondary accessions : Q5VYZ4 Q5VYZ7 Q7L4C3 Q7L5E2 Q8IXA6 Q8TEW5 Q8TF04 Q96HB6 Q9BQ64 Q9NV84Alternative splicing : 7 isoforms : Q9H869-1 Q9H869-2 Q9H869-3 Q9H869-4 Q9H869-5 Q9H869-6 Q9H869-7
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_620829.1 NP_620830.1 ENSEMBL proteins: ENSP00000295566 ENSP00000357324 ENSP00000347686 ENSP00000316079 ENSP00000357314 ENSP00000385390 ENSP00000346722 ENSP00000352134 ENSP00000311138 ENSP00000355298 ENSP00000385791 ENSP00000357323 ENSP00000354716 ENSP00000384583 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: YY1AP1 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for YY1AP1: Assays for YY1AP1:
Protein
Domains/ Families for YY1AP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q9H869
Gene Function for YY1AP1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
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siRNAs from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_018253 Applied Biosystems Silencer ® siRNAs for YY1AP1 Sigma-Aldrich siRNA for YY1AP1 Sigma-Aldrich shRNA for YY1AP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_139118                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_139118                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_139118  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_139118 UniProtKB/Swiss-Prot: YYAP1_HUMAN, Q9H869 Function : Enhances transcription activation by YY1
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for YY1AP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for YY1AP1 4 Interacting proteins for YY1AP1 (ENSP00000357324 3 Q9H869 1 , 2 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for YY1AP1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for YY1AP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_018253 Sigma-Aldrich siRNA for YY1AP1 Sigma-Aldrich shRNA for YY1AP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_139118 NM_139119
REFSEQ mRNAs for YY1AP1 gene (2 alternative transcripts): NM_139118.1 NM_139119.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_139118 NM_139119
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_139118                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_139118                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_139118  
Additional cDNA sequence: AF203474.1 AF206328.1 AF466401.1 AK001737.1 AK023976.1 AK125590.1 AK225883.1 AK297562.1 AK298904.1 AK303046.1 AK303386.1 AK303944.1 AK309701.1 AK315049.1 AM413020.1 AY604179.1 BC001655.2 BC001843.2 BC003500.1 BC008766.2 BC009358.2 BC014906.2 BC025272.1 BC044887.1 CR602188.1 CR622167.1 CR749789.1
24/50 DOTS entries (see all 50
): DT.100038088 DT.91775860 DT.100884359 DT.100884357 DT.92400830 DT.451937 DT.95306306 DT.100884358 DT.95193917 DT.91775856 DT.100884346 DT.100884352 DT.95120355 DT.91861896 DT.95148758 DT.95148764 DT.100884355 DT.92418330 DT.100884345 DT.95148784 DT.100884353 DT.91904904 DT.100038083 DT.100884336
24/641 AceView cDNA sequences (see all 641
):BU517143 CA454895 BQ065651 BC025272 AW009174 CA435576 AK001737 BE397043 BM707773 AI201162 BC014906 BX458376 CA407365 BE409407 CF552001 CB133392 NM_139121 BM975479 AW328059 BQ026343 AI366829 CR622167 AW410154 AF466401
highest scoring ESTs for YY1AP1 :AK023976 AU142422 AU280465 BC003500 AA324812 AA336250 AA432022 AA451818 AA609937 AA693994
Unigene Cluster for YY1AP1: YY1 associated protein 1 Hs.584927 [show with all ESTs ] Unigene Representative Sequence: BC025272 GeneLoc Exon Structure 5/15 Alternative Splicing Database (ASD) splice patterns (SP) for YY1AP1 (see all 15
) ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · SP1 :             -             -         -   -                   SP2 :           -   -       -       -         -   -                   SP3 :                   -       -         -   -                   SP4 :   -   -   -   -   -   -       -       -         -   -                   SP5 :           -   -       -       -                            
ExUns: 14d · 14e ^ 15 ^ 16 ^ 17a · 17b ^ 18 SP1 :               SP2 :               SP3 :               SP4 :               SP5 :              
About this scheme ECgene alternative splicing isoforms for YY1AP1 14 Ensembl transcripts including schematic representations : ENST00000295566
ENST00000368340
ENST00000355499
ENST00000347088
ENST00000368330
ENST00000404643
ENST00000354691
ENST00000359205
ENST00000311573
ENST00000361831
ENST00000407221
ENST00000368339
ENST00000361140
ENST00000405763
Expression for YY1AP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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YY1AP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for YY1AP1 1 / 2 / 3
3 probe-sets matching YY1AP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AATGTGGACASOURCE GeneReport for Unigene cluster: Hs.584927 UniProtKB/Swiss-Prot: YYAP1_HUMAN, Q9H869 Tissue specificity : Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas,brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highlyexpressed in most liver carcinomas
Orthologs for YY1AP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
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Gene Trees according to Ensembl )
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ENSEMBL Gene Tree for YY1AP1 Paralogs for YY1AP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for YY1AP1 gene GON4L 2
SNPs/Variants for YY1AP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for YY1AP1 (up to first 250kb)
Disorders & Mutations for YY1AP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607860
Medical News for YY1AP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for YY1AP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/22 PubMed articles for YY1AP1 gene (see all 22
): Identification and characterization of a novel human hepatocellular carcinoma-associated gene. (PubMed id 11710830) 1, 2, 3, 4 Wang Z.X....Wu M.C. (2001) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) YY1AP, a novel co-activator of YY1. (PubMed id 14744866) 3, 4 Wang C.-Y.... Yu W.C.Y. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma. (PubMed id 12118372) 3, 4 Zeng J.Z.... Wu M.-C. (2002) Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. (PubMed id 17541814) 1, 3 Li L....Huo K. (2007) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569) 3 Lim J....Zoghbi H.Y. (2006)
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Genome Databases showing YY1AP1
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Specialized Databases showing YY1AP1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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