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Aliases for YY1AP1 Gene

Aliases for YY1AP1 Gene

  • YY1 Associated Protein 1 2 3 5
  • Hepatocellular Carcinoma Susceptibility Protein 3 4
  • Hepatocellular Carcinoma-Associated Protein 2 3 4
  • HCCA2 3 4
  • YY1AP 3 4
  • HCCA1 3
  • YAP 3

External Ids for YY1AP1 Gene

Previous GeneCards Identifiers for YY1AP1 Gene

  • GC01M152444
  • GC01M153895
  • GC01M155630
  • GC01M126991

Summaries for YY1AP1 Gene

Entrez Gene Summary for YY1AP1 Gene

  • The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for YY1AP1 Gene

YY1AP1 (YY1 Associated Protein 1) is a Protein Coding gene. Diseases associated with YY1AP1 include Hepatocellular Carcinoma. An important paralog of this gene is GON4L.

UniProtKB/Swiss-Prot for YY1AP1 Gene

  • Enhances transcription activation by YY1. May play a role in cell cycle regulation.

Gene Wiki entry for YY1AP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YY1AP1 Gene

Genomics for YY1AP1 Gene

Regulatory Elements for YY1AP1 Gene

Enhancers for YY1AP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YY1AP1 on UCSC Golden Path with GeneCards custom track

Promoters for YY1AP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YY1AP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the YY1AP1 gene promoter:

Genomic Location for YY1AP1 Gene

155,659,442 bp from pter
155,689,032 bp from pter
29,591 bases
Minus strand

Genomic View for YY1AP1 Gene

Genes around YY1AP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YY1AP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YY1AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YY1AP1 Gene

Proteins for YY1AP1 Gene

  • Protein details for YY1AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    YY1-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • B0QZ54
    • B4DMP2
    • B4E0I0
    • D3DV96
    • D3DV98
    • H7BY62
    • Q5VYZ1
    • Q5VYZ4
    • Q5VYZ7
    • Q7L4C3
    • Q7L5E2
    • Q8IXA6
    • Q8TEW5
    • Q8TF04
    • Q96HB6
    • Q9BQ64
    • Q9NV84

    Protein attributes for YY1AP1 Gene

    796 amino acids
    Molecular mass:
    87944 Da
    Quaternary structure:
    • Interacts with YY1. Interacts with MAD2L2.
    • Sequence=BAA91871.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for YY1AP1 Gene

neXtProt entry for YY1AP1 Gene

Proteomics data for YY1AP1 Gene at MOPED

Post-translational modifications for YY1AP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for YY1AP1 Gene

Domains & Families for YY1AP1 Gene

Protein Domains for YY1AP1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with YY1AP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for YY1AP1 Gene

Function for YY1AP1 Gene

Molecular function for YY1AP1 Gene

UniProtKB/Swiss-Prot Function:
Enhances transcription activation by YY1. May play a role in cell cycle regulation.
genes like me logo Genes that share phenotypes with YY1AP1: view

miRNA for YY1AP1 Gene

miRTarBase miRNAs that target YY1AP1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YY1AP1 Gene

Localization for YY1AP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YY1AP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for YY1AP1 Gene COMPARTMENTS Subcellular localization image for YY1AP1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for YY1AP1 Gene

Pathways & Interactions for YY1AP1 Gene

SuperPathways for YY1AP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for YY1AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051726 regulation of cell cycle IDA 17541814
genes like me logo Genes that share ontologies with YY1AP1: view

No data available for Pathways by source and SIGNOR curated interactions for YY1AP1 Gene

Drugs & Compounds for YY1AP1 Gene

No Compound Related Data Available

Transcripts for YY1AP1 Gene

Unigene Clusters for YY1AP1 Gene

YY1 associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YY1AP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ·
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - -
SP11: -
SP12: - -
SP13: - -

ExUns: 14d · 14e ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP9: - - - -
SP12: -
SP14: -

Relevant External Links for YY1AP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YY1AP1 Gene

mRNA expression in normal human tissues for YY1AP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YY1AP1 Gene

This gene is overexpressed in Lung (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YY1AP1 Gene

SOURCE GeneReport for Unigene cluster for YY1AP1 Gene Hs.584927

mRNA Expression by UniProt/SwissProt for YY1AP1 Gene

Tissue specificity: Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas.
genes like me logo Genes that share expression patterns with YY1AP1: view

Protein tissue co-expression partners for YY1AP1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for YY1AP1 Gene

Orthologs for YY1AP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for YY1AP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YY1AP1 35
  • 99.64 (n)
  • 99.2 (a)
YY1AP1 36
  • 97 (a)
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
-- 36
  • 29 (a)
(Canis familiaris)
Mammalia -- 36
  • 1 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
-- 36
  • 24 (a)
(Mus musculus)
Mammalia Gon4l 36
  • 25 (a)
(Gallus gallus)
Aves -- 36
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
(Danio rerio)
Actinopterygii si:dkey-27c15.3 36
  • 12 (a)
fruit fly
(Drosophila melanogaster)
Insecta mute 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
Species with no ortholog for YY1AP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YY1AP1 Gene

Gene Tree for YY1AP1 (if available)
Gene Tree for YY1AP1 (if available)

Paralogs for YY1AP1 Gene

Paralogs for YY1AP1 Gene

(2) SIMAP similar genes for YY1AP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with YY1AP1: view

Variants for YY1AP1 Gene

Sequence variations from dbSNP and Humsavar for YY1AP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35098429 - 155,660,814(-) ATCAA(A/G)GCCTA reference, missense, utr-variant-3-prime
rs7539 - 155,659,692(-) AACCT(C/G)AAGAT reference, missense, utr-variant-3-prime
rs182978 -- 155,660,671(-) CTGAA(A/G)CCCCT reference, synonymous-codon, utr-variant-3-prime
rs348185 -- 155,664,006(-) tttaa(A/G)acatg intron-variant
rs348186 -- 155,663,516(-) gtctc(A/G)aactc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YY1AP1 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV Loss 17666407
esv2718418 CNV Deletion 23290073
nsv428246 CNV Gain 18775914
nsv436522 CNV Deletion 17901297
esv2718429 CNV Deletion 23290073
nsv3054 CNV Loss 18451855

Variation tolerance for YY1AP1 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for YY1AP1 Gene

Disorders for YY1AP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for YY1AP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for YY1AP1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with YY1AP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YY1AP1 Gene

Publications for YY1AP1 Gene

  1. Identification and characterization of a novel human hepatocellular carcinoma-associated gene. (PMID: 11710830) Wang Z.-X. … Wu M.-C. (Br. J. Cancer Suppl. 2001) 2 3 4 23 67
  2. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. (PMID: 17541814) Li L. … Huo K. (Mol. Cell. Biochem. 2007) 3 23
  3. Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma. (PMID: 25597408) Zhao X. … Wang X.W. (Oncogene 2015) 3
  4. YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. (PMID: 25798835) He C. … Wang C. (Oncogene 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for YY1AP1 Gene

Sources for YY1AP1 Gene