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Aliases for YY1 Gene

Aliases for YY1 Gene

  • YY1 Transcription Factor 2 3
  • INO80 Complex Subunit S 2 3 4
  • Delta Transcription Factor 3 4
  • Yin And Yang 1 Protein 2 3
  • INO80S 3 4
  • NF-E1 3 4
  • YY-1 3 4
  • Transcriptional Repressor Protein YY1 3
  • Yin And Yang 1 4
  • YIN-YANG-1 3
  • Delta 3
  • UCRBP 3

External Ids for YY1 Gene

Summaries for YY1 Gene

Entrez Gene Summary for YY1 Gene

  • YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]

GeneCards Summary for YY1 Gene

YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with YY1 include hailey-hailey disease and cervical intraepithelial neoplasia. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Cell Cycle / Checkpoint Control. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is ZFP42.

UniProtKB/Swiss-Prot for YY1 Gene

  • Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5-CCGCCATNTT-3; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5-GTCT/AGAC-3) within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements

Gene Wiki entry for YY1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YY1 Gene

Genomics for YY1 Gene

Genomic Location for YY1 Gene

Start:
100,238,298 bp from pter
End:
100,282,792 bp from pter
Size:
44,495 bases
Orientation:
Plus strand

Genomic View for YY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YY1 Gene

Proteins for YY1 Gene

  • Protein details for YY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25490-TYY1_HUMAN
    Recommended name:
    Transcriptional repressor protein YY1
    Protein Accession:
    P25490
    Secondary Accessions:
    • Q14935

    Protein attributes for YY1 Gene

    Size:
    414 amino acids
    Molecular mass:
    44713 Da
    Quaternary structure:
    • Found in a complex with SMAD1 and SMAD4. Interacts with YAF2 through the region encompassing the first and second zinc fingers. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex. Interacts with SFMBT2.

    Three dimensional structures from OCA and Proteopedia for YY1 Gene

neXtProt entry for YY1 Gene

Proteomics data for YY1 Gene at MOPED

Post-translational modifications for YY1 Gene

  • Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys332

Other Protein References for YY1 Gene

No data available for DME Specific Peptides for YY1 Gene

Domains for YY1 Gene

Gene Families for YY1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • INO80 :INO80 complex subunits

Protein Domains for YY1 Gene

UniProtKB/Swiss-Prot:

TYY1_HUMAN
Family:
  • Belongs to the YY transcription factor family.:
    • P25490
Similarity:
  • Contains 4 C2H2-type zinc fingers.:
    • P25490
genes like me logo Genes that share domains with YY1: view

Function for YY1 Gene

Molecular function for YY1 Gene

GENATLAS Biochemistry: YY1 transcription factor,repressor/activator (Yin Yang) protein,binding to a variety of transcriptor factors,recruiting HDAC2 or HDAC3 for negative regulation of transcription. Interacting with MYC
UniProtKB/Swiss-Prot Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5-CCGCCATNTT-3; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5-GTCT/AGAC-3) within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).
UniProtKB/Swiss-Prot Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements

Gene Ontology (GO) - Molecular Function for YY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000400 four-way junction DNA binding IDA 18026119
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS --
GO:0001158 enhancer sequence-specific DNA binding IMP 15329343
GO:0003677 DNA binding IDA 21729784
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 1946405
genes like me logo Genes that share ontologies with YY1: view
genes like me logo Genes that share phenotypes with YY1: view

Animal Models for YY1 Gene

MGI Knock Outs for YY1:
Targeting motifs for YY1 Gene
HOMER Transcription Factor Regulatory Elements motif YY1
  • Consensus sequence: CAAGATGGCGGC Submotif: canonical Cell Type: NA

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for YY1 Gene

Localization for YY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YY1 Gene

Nucleus matrix. Note=Associated with the nuclear matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YY1 Gene COMPARTMENTS Subcellular localization image for YY1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for YY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 22065573
GO:0005667 transcription factor complex IEA --
GO:0016363 nuclear matrix IEA --
GO:0031011 Ino80 complex IDA 18026119
GO:0031519 PcG protein complex IEA --
genes like me logo Genes that share ontologies with YY1: view

Pathways for YY1 Gene

genes like me logo Genes that share pathways with YY1: view

Pathways by source for YY1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for YY1 Gene
3 Cell Signaling Technology pathways for YY1 Gene

Gene Ontology (GO) - Biological Process for YY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9857059
GO:0000724 double-strand break repair via homologous recombination IMP 18026119
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1655281
genes like me logo Genes that share ontologies with YY1: view

Compounds for YY1 Gene

(26) Novoseek inferred chemical compound relationships for YY1 Gene

Compound -log(P) Hits PubMed IDs
zinc 56.9 43
atpa 40.8 6
hpvs 27.2 1
chloramphenicol 22.5 1
butyrate 22.2 1
genes like me logo Genes that share compounds with YY1: view

Transcripts for YY1 Gene

Unigene Clusters for YY1 Gene

YY1 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YY1 Gene

No ASD Table

Relevant External Links for YY1 Gene

GeneLoc Exon Structure for
YY1
ECgene alternative splicing isoforms for
YY1

Expression for YY1 Gene

mRNA expression in normal human tissues for YY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for YY1 Gene

SOURCE GeneReport for Unigene cluster for YY1 Gene Hs.388927

genes like me logo Genes that share expressions with YY1: view

Orthologs for YY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for YY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YY1 36
  • 99.9 (n)
  • 100 (a)
YY1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia YY1 36
  • 92.51 (n)
  • 93.48 (a)
YY1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YY1 36
  • 96.5 (n)
  • 99.02 (a)
YY1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yy1 36
  • 90.78 (n)
  • 92.72 (a)
Yy1 16
Yy1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Yy1 36
  • 90.92 (n)
  • 94.89 (a)
chicken
(Gallus gallus)
Aves YY1 36
  • 83.09 (n)
  • 85.64 (a)
YY1 37
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 99 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia yy1-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.829 36
yy1 36
  • 79.25 (n)
  • 89.22 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1785 36
zebrafish
(Danio rerio)
Actinopterygii yy1a 36
  • 78.06 (n)
  • 85.99 (a)
yy1a 37
  • 86 (a)
ManyToMany
yy1b 37
  • 75 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta pho 37
  • 30 (a)
ManyToMany
phol 37
  • 20 (a)
ManyToMany
phol 38
  • 64 (a)
pho 38
  • 93 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2999 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToMany
Species with no ortholog for YY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YY1 Gene

ENSEMBL:
Gene Tree for YY1 (if available)
TreeFam:
Gene Tree for YY1 (if available)

Paralogs for YY1 Gene

Paralogs for YY1 Gene

Pseudogenes.org Pseudogenes for YY1 Gene

genes like me logo Genes that share paralogs with YY1: view

Variants for YY1 Gene

Sequence variations from dbSNP and Humsavar for YY1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs752559 -- 100,263,373(+) ATGAC(A/T)GGAGG intron-variant
rs997514 -- 100,241,246(-) GAGGT(C/T)CCACC intron-variant
rs1054407 -- 100,239,219(-) CGGCC(C/G)CGGCG utr-variant-5-prime
rs1803878 -- 100,262,317(+) AAAGA(G/T)ATTGA missense, reference
rs1986964 -- 100,241,787(-) TATGA(C/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YY1 Gene

Variant ID Type Subtype PubMed ID
nsv902226 CNV Loss 21882294
nsv832875 CNV Loss 17160897
nsv827052 CNV Gain 20364138
esv22463 CNV Loss 19812545
esv2749105 CNV Deletion 23290073
esv2749106 CNV Deletion 23290073
esv2749108 CNV Deletion 23290073
nsv827054 CNV Gain 20364138

Relevant External Links for YY1 Gene

HapMap Linkage Disequilibrium report
YY1
Human Gene Mutation Database (HGMD)
YY1

Disorders for YY1 Gene

(1) University of Copenhagen DISEASES for YY1 Gene

(25) Novoseek inferred disease relationships for YY1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 28.7 6
osteosarcoma 22.2 8
cervical cancer 21.8 8
cancer 21.7 19
burkitt lymphoma 20.4 1

Relevant External Links for YY1

Genetic Association Database (GAD)
YY1
Human Genome Epidemiology (HuGE) Navigator
YY1
Tumor Gene Database (TGDB):
YY1
genes like me logo Genes that share disorders with YY1: view

No data available for UniProtKB/Swiss-Prot for YY1 Gene

Publications for YY1 Gene

  1. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. (PMID: 1946405) Park K. … Atchison M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  2. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PMID: 9016636) Kalenik J.L. … Lee T.-C. (Nucleic Acids Res. 1997) 3 4 23
  3. YY1 functions with INO80 to activate transcription. (PMID: 17721549) Cai Y. … Conaway J.W. (Nat. Struct. Mol. Biol. 2007) 3 4 23
  4. YY1's longer DNA-binding motifs. (PMID: 18950698) Kim J. … Kim J. (Genomics 2009) 3 4 23
  5. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. (PMID: 1655281) Shi Y. … Shenk T. (Cell 1991) 2 3 4

Products for YY1 Gene

  • Addgene plasmids for YY1

Sources for YY1 Gene

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