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YY1 Gene

protein-coding   GIFtS: 68
GCID: GC14P101221

YY1 Transcription Factor

  See YY1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
YY1 Transcription Factor1 2     YY-12 3
INO80 Complex Subunit S1 2 3     DELTA2
Yin And Yang 1 Protein1 2     UCRBP2
Delta Transcription Factor2 3     YIN-YANG-12
INO80S2 3     Transcriptional Repressor Protein YY12
NF-E12 3     Yin And Yang 13

External Ids:    HGNC: 128561   Entrez Gene: 75282   Ensembl: ENSG000001008117   OMIM: 6000135   UniProtKB: P254903   

Export aliases for YY1 gene to outside databases

Previous GC identifers: GC14P098216 GC14P094520 GC14P098695 GC14P099774 GC14P100992 GC14P101002 GC14P080888 GC14P101020 GC14P101031 GC14P101051 GC14P101071 GC14P101112 GC14P101161


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YY1 Gene:
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins.
The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone
deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus
implicating histone modification in the function of YY1. (provided by RefSeq, Jul 2008)

GeneCards Summary for YY1 Gene:
YY1 (YY1 transcription factor) is a protein-coding gene. Diseases associated with YY1 include hailey-hailey disease, and cervical intraepithelial neoplasia. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF787.

UniProtKB/Swiss-Prot: TYY1_HUMAN, P25490
Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of
cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus
sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced
binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on
transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include
direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or
repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by
transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit
YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein
but as an activator in its presence. May play an important role in development and differentiation. Proposed to
recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In
vitro, binds to DNA recombination intermediate structures (Holliday junctions)
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive
elements

Gene Wiki entry for YY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the YY1 gene promoter:
         Max1   TBP   AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   NF-kappaB1   c-Myc   AP-2alphaA   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for YY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q

YY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YY1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P101221:  view genomic region     (about GC identifiers)

Start:
100,704,635 bp from pter      End:
100,749,129 bp from pter
Size:
44,495 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TYY1_HUMAN, P25490 (See protein sequence)
Recommended Name: Transcriptional repressor protein YY1  
Size: 414 amino acids; 44713 Da
Subunit: Interacts with YAF2 through the region encompassing the first and second zinc fingers. Component of the
chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of
INO80. Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2
complex. Interacts with SFMBT2
3 PDB 3D structures from and Proteopedia for YY1:
1UBD (3D)        1ZNM (3D)        4C5I (3D)    
Secondary accessions: Q14935

Explore the universe of human proteins at neXtProt for YY1: NX_P25490

Explore proteomics data for YY1 at MOPED

Post-translational modifications: 

  • Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its
    cognate DNA binding sites1
  • Ubiquitinated1
  • Ubiquitination2 at Lys332
  • Modification sites at PhosphoSitePlus

  • See YY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003394.1  
    ENSEMBL proteins: 
     ENSP00000451329   ENSP00000262238   ENSP00000452140   ENSP00000452225  

    YY1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for YY1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for YY1
    GenScript Custom Purified and Recombinant Proteins Services for YY1
    Novus Biologicals YY1 Proteins
    Novus Biologicals YY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for YY1

     
    Search eBioscience for Proteins for YY1 

     
    antibodies-online proteins for YY1 (4 products) 

     
    antibodies-online peptides for YY1

    YY1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YY1
    R&D Systems Antibodies for YY1
    Cell Signaling Technology (CST) Antibodies for YY1 
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    OriGene Custom Antibody Services for YY1
    Novus Biologicals YY1 Antibodies
    Abcam antibodies for YY1
    Cloud-Clone Corp. Antibodies for YY1
    ThermoFisher Antibody for YY1
    antibodies-online antibodies for YY1 (95 products) 

    YY1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YY1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YY1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for YY1
    Cloud-Clone Corp. CLIAs for YY1
    Search eBioscience for ELISAs for YY1 
    antibodies-online kits for YY1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    INO80: INO80 complex subunits
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR017114 TF_Yin_yang
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P25490

    ProtoNet protein and cluster: P25490

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: TYY1_HUMAN, P25490
    Similarity: Belongs to the YY transcription factor family
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with YY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYY1_HUMAN, P25490
    Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of
    cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus
    sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced
    binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on
    transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include
    direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or
    repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by
    transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit
    YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein
    but as an activator in its presence. May play an important role in development and differentiation. Proposed to
    recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In
    vitro, binds to DNA recombination intermediate structures (Holliday junctions)
    Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive
    elements

         Genatlas biochemistry entry for YY1:
    YY1 transcription factor,repressor/activator (Yin Yang) protein,binding to a variety of transcriptor
    factors,recruiting HDAC2 or HDAC3 for negative regulation of transcription. Interacting with MYC

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000400four-way junction DNA binding IDA18026119
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription ISS--
    GO:0003677DNA binding IDA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1946405
    GO:0003713transcription coactivator activity TAS1946405
         
    Find genes that share ontologies with YY1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for YY1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Yy1):
     cellular  embryogenesis  growth/size/body  homeostasis/metabolism  integument 
     mortality/aging  nervous system  normal  respiratory system 

    Find genes that share phenotypes with YY1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Yy1tm1Yshi for YY1

       genOway: Develop your customized and physiologically relevant rodent model for YY1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CAAGATGGCGGC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target YY1:
    hsa-mir-221-3p (MIRT046848), hsa-mir-34a-5p (MIRT004045), hsa-mir-484 (MIRT041821), hsa-mir-31-5p (MIRT004968), hsa-mir-331-3p (MIRT043278), hsa-mir-769-3p (MIRT039108), hsa-mir-615-3p (MIRT040246), hsa-mir-93-5p (MIRT028073)

    Block miRNA regulation of human, mouse, rat YY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YY1 (see all 67):
    hsa-miR-411* hsa-miR-3152-3p hsa-miR-300 hsa-miR-200a hsa-miR-502-3p hsa-miR-890 hsa-miR-629 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidYY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YY1
    Predesigned siRNA for gene silencing in human, mouse, rat YY1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for YY1

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YY1 (NM_003403)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YY1
    Addgene plasmids for YY1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YY1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYY1_HUMAN, P25490: Nucleus matrix. Note=Associated with the nuclear matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18026119
    GO:0005667transcription factor complex IEA--
    GO:0005886plasma membrane ----
    GO:0016363nuclear matrix IEA--
    GO:0031011Ino80 complex IDA18026119

    Find genes that share ontologies with YY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YY1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31
    4Translational Control
    Translational Control
    5Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I


    Find genes that share SuperPaths with YY1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for YY1
        Apoptosis and Autophagy
    Translational Control
    Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for YY1
        Development TGF-beta receptor signaling

    Selected BioSystems Pathways for YY1 (see all 8)
        SREBP signalling
    Delta-Notch Signaling Pathway
    E2F transcription factor network
    mTOR signaling pathway
    Signaling events mediated by HDAC Class I


        Pathway & Disease-focused RT2 Profiler PCR Arrays including YY1 (see all 6): 
              HIV Host Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Transcription Factors in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YY1 (P254901, 2, 3 ENSP000002622384) via UniProtKB, MINT, STRING, and/or I2D (see all 753)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9857059
    GO:0000724double-strand break repair via homologous recombination IMP18026119
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1655281
    GO:0006403RNA localization IEA--

    Find genes that share ontologies with YY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for YY1 (TYY1)

    Selected Novoseek inferred chemical compound relationships for YY1 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 56.9 55 9199306 (2), 15087442 (2), 16865673 (2), 8134108 (2) (see all 35)
    atpa 40.8 7 8882641 (4), 9840809 (2)
    hpvs 27.2 1 9557642 (1)
    chloramphenicol 22.5 2 8941348 (1)
    butyrate 22.2 1 17761837 (1)
    adpribose 19.6 1 9928945 (1)
    steroid 16.1 1 9238849 (1)
    sterol 11.9 2 10318878 (1), 9712863 (1)
    oligonucleotide 8.66 9 8114709 (2), 10022610 (1), 8524292 (1), 8882641 (1) (see all 7)
    thymidine 6.44 2 10022610 (1), 8137827 (1)



    Find genes that share compounds with YY1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YY1 gene: 
    NM_003403.4  

    Unigene Clusters for YY1:

    YY1 transcription factor
    Hs.388927  [show with all ESTs], Hs.603118  [show with all ESTs]
    Unigene Representative Sequences: BX647456, AK026497
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554371 ENST00000262238(uc001ygy.1) ENST00000553625 ENST00000554804
    ENST00000554579
    miRNA
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    Block miRNA regulation of human, mouse, rat YY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YY1 (see all 67):
    hsa-miR-411* hsa-miR-3152-3p hsa-miR-300 hsa-miR-200a hsa-miR-502-3p hsa-miR-890 hsa-miR-629 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidYY1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: YY1 (NM_003403)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YY1
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    Addgene plasmids for YY1 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YY1
      QuantiTect SYBR Green Assays in human, mouse, rat YY1
      QuantiFast Probe-based Assays in human, mouse, rat YY1

    Additional mRNA sequence: 

    AK025731.1 AK026497.1 BC014138.2 BC051735.1 

    19 DOTS entries:

    DT.99968873  DT.97783673  DT.454649  DT.97859625  DT.91896772  DT.100036764  DT.120772238  DT.445428 
    DT.99945655  DT.438109  DT.87078356  DT.109199  DT.120772338  DT.92394371  DT.100756454  DT.100804359 
    DT.100830714  DT.40119043  DT.92450425 

    Selected AceView cDNA sequences (see all 829):

    AA904792 AI268411 AI472042 BF061123 AA478665 AW516296 AA453666 AW006985 
    AI354758 AU118648 BQ058946 BE672497 AW450700 AA813345 BM692970 CB148399 
    BF112150 CD244084 CR592603 D11998 BF056850 BG941866 BF439657 AI797679 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACAGAAAG
    YY1 Expression
    About this image


    YY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    YY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YY1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.388927 Hs.603118
        Pathway & Disease-focused RT2 Profiler PCR Arrays including YY1 (see all 6): 
              HIV Host Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Transcription Factors in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YY1
    OriGene qSTAR qPCR primer pairs in human, mouse for YY1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YY1
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    QuantiFast Probe-based Assays in human, mouse, rat YY1
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for YY1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Yy11 , 5 YY1 transcription factor1, 5 90.78(n)1
    92.72(a)1
      12 (59.58 cM)5
    226321  NM_009537.31  NP_033563.21 
     1087929735 
    chicken
    (Gallus gallus)
    Aves YY11 YY1 transcription factor 83.09(n)
    85.64(a)
      423455  NM_001031210.1  NP_001026381.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    GL343270.1(988957-993664)
    African clawed frog
    (Xenopus laevis)
    Amphibia yy1-A-prov2 YY1 transcription factor 82.16(n)    X77698.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF389345.12   -- 82.07(n)    AF389345.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pho3 transcription factor 93(a)
    (best of 2)
      102D6   --


    ENSEMBL Gene Tree for YY1 (if available)
    TreeFam Gene Tree for YY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YY1 gene
    ZNF7872  YY22  ZFP422  ZNF8532  
    16 SIMAP similar genes for YY1 using alignment to 4 protein entries:     TYY1_HUMAN (see all proteins):
    ZIC1    ZNF410    ZFP42    GTF3A    YY2    ZFS-5
    DKFZp434J0650    kr-znf3    ZNF323    HZF16    ZNF72    ZNF
    DKFZp686N0199    KLF1    ZFS-6    ZNF78L1

    Find genes that share paralogs with YY1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for YY1
    PGOHUM00000238524 PGOHUM00000240965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YY1 (see all 935)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895960301,2
    --100703120(+) CATAAA/GATACT 1 -- us2k10--------
    rs1422988671,2
    C--100703193(+) CACCTA/CCTATG 1 -- us2k10--------
    rs2017822971,2
    --100703370(+) ATGGG-/TTAATT 1 -- us2k10--------
    rs93335721,2
    F--100703371(+) GGGTT-/TAATTC 1 -- us2k1 tfbs31Minor allele frequency- T:0.02EU 206
    rs1161805251,2
    F--100703587(+) CAGATT/CTGACT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1440710411,2
    --100703647(+) AAAGC-/TCAGAT
            
    TCAAA
    1 -- us2k10--------
    rs1477743311,2
    --100703714(+) GTCCAA/GTGCGA 1 -- us2k10--------
    rs1503361681,2
    --100703814(+) AATGTA/GTTGCG 1 -- us2k10--------
    rs1812046181,2
    --100703882(+) GTTGAC/TAATAT 1 -- us2k10--------
    rs93335731,2
    C,F,A,H--100704013(+) TAAGGC/TAAATT 1 -- us2k128Minor allele frequency- T:0.25EU NS EA NA WA CSA 2745

    HapMap Linkage Disequilibrium report for YY1 (100704635 - 100749129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for YY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749108CNV Deletion23290073
    esv2749105CNV Deletion23290073
    esv2749106CNV Deletion23290073
    esv22463CNV Loss19812545
    nsv902226CNV Loss21882294
    nsv832875CNV Loss17160897
    nsv827054CNV Gain20364138
    nsv827052CNV Gain20364138

    Human Gene Mutation Database (HGMD): YY1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YY1
    DNA2.0 Custom Variant and Variant Library Synthesis for YY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600013    OMIM disorders: --

    2 diseases for YY1:    
    About MalaCards
    hailey-hailey disease    cervical intraepithelial neoplasia

    1 disease from the University of Copenhagen DISEASES database for YY1:
    Cancer

    Find genes that share disorders with YY1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for YY1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 28.7 10 11118439 (5), 12588874 (1)
    osteosarcoma 22.2 9 16962318 (3), 18488713 (3), 18339860 (2)
    cervical cancer 21.8 10 10385547 (3), 7927871 (1), 10466808 (1), 12526319 (1) (see all 6)
    cancer 21.7 26 20081375 (3), 18218085 (2), 19342874 (2), 15870067 (1) (see all 15)
    burkitt lymphoma 20.4 1 20081364 (1)
    tumors 19.7 42 16784892 (4), 18218085 (4), 16314846 (3), 17911631 (3) (see all 23)
    carcinoma embryonal 6.82 1 16003908 (1)
    hypertrophy 5.56 4 18632988 (2)
    leukemia 0 3 7821790 (1)
    herpes simplex 0 1 7784186 (1)

    Genetic Association Database (GAD): YY1
    Human Genome Epidemiology (HuGE) Navigator: YY1 (10 documents)
    Tumor Gene Database (TGDB): YY1

    Export disorders for YY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YY1 gene, integrated from 10 sources (see all 439):
    (articles sorted by number of sources associating them with YY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. (PubMed id 1655281)1, 2, 3 Shi Y.... Shenk T. (Cell 1991)
    2. YY1's longer DNA-binding motifs. (PubMed id 18950698)1, 2, 9 Kim J. and Kim J. (Genomics 2009)
    3. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. (PubMed id 1946405)1, 2, 9 Park K. and Atchison M. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    4. YY1 functions with INO80 to activate transcription. (PubMed id 17721549)1, 2, 9 Cai Y.... Conaway J.W. (Nat. Struct. Mol. Biol. 2007)
    5. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PubMed id 9016636)1, 2, 9 Kalenik J.L.... Lee T.-C. (Nucleic Acids Res. 1997)
    6. Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. (PubMed id 8942976)1, 2, 9 Houbaviy H.B.... Burley S.K. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    7. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (J. Biol. Chem. 2011)
    8. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)1, 2 Del RincA^n S.V....Spruck C. (PLoS ONE 2010)
    9. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T.... Conaway J.W. (Mol. Cell 2008)
    10. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. (PubMed id 18026119)1, 2 Wu S.... Shi Y. (Nat. Struct. Mol. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7528 HGNC: 12856 AceView: YY1 Ensembl:ENSG00000100811 euGenes: HUgn7528
    ECgene: YY1 H-InvDB: YY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YY1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YY1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YY1 gene:
    Search GeneIP for patents involving YY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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