Free for academic non-profit institutions. Other users need a Commercial license

Aliases for YY1 Gene

Aliases for YY1 Gene

  • YY1 Transcription Factor 2 3 5
  • INO80 Complex Subunit S 2 3 4
  • Delta Transcription Factor 3 4
  • Yin And Yang 1 Protein 2 3
  • INO80S 3 4
  • NF-E1 3 4
  • YY-1 3 4
  • Transcriptional Repressor Protein YY1 3
  • Yin And Yang 1 4
  • YIN-YANG-1 3
  • Delta 3
  • UCRBP 3

External Ids for YY1 Gene

Previous GeneCards Identifiers for YY1 Gene

  • GC14P098216
  • GC14P094520
  • GC14P098695
  • GC14P099774
  • GC14P100992
  • GC14P101002
  • GC14P080888
  • GC14P101020
  • GC14P101031
  • GC14P101051
  • GC14P101071
  • GC14P101112
  • GC14P101161
  • GC14P101221

Summaries for YY1 Gene

Entrez Gene Summary for YY1 Gene

  • YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]

GeneCards Summary for YY1 Gene

YY1 (YY1 Transcription Factor) is a Protein Coding gene. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Notch-mediated HES/HEY network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is YY2.

UniProtKB/Swiss-Prot for YY1 Gene

  • Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5-CCGCCATNTT-3; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5-GTCT/AGAC-3) within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.

Gene Wiki entry for YY1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YY1 Gene

Genomics for YY1 Gene

Regulatory Elements for YY1 Gene

Enhancers for YY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around YY1 on UCSC Golden Path with GeneCards custom track

Promoters for YY1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for YY1 Gene

Chromosome:
14
Start:
100,238,298 bp from pter
End:
100,282,792 bp from pter
Size:
44,495 bases
Orientation:
Plus strand

Genomic View for YY1 Gene

Genes around YY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YY1 Gene

Proteins for YY1 Gene

  • Protein details for YY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25490-TYY1_HUMAN
    Recommended name:
    Transcriptional repressor protein YY1
    Protein Accession:
    P25490
    Secondary Accessions:
    • Q14935

    Protein attributes for YY1 Gene

    Size:
    414 amino acids
    Molecular mass:
    44713 Da
    Quaternary structure:
    • Interacts with YAF2 through the region encompassing the first and second zinc fingers (PubMed:9016636). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (PubMed:17721549, PubMed:18026119, PubMed:18922472, PubMed:21303910). Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex (PubMed:11158321). Interacts with SFMBT2 (PubMed:23385818). Found in a complex with SMAD1 and SMAD4 (PubMed:15329343). Found in a complex with YY1, SIN3A and HDAC1 (By similarity).
    • Interacts with YAF2 through the region encompassing the first and second zinc fingers (PubMed:9016636). Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80 (PubMed:17721549, PubMed:18026119, PubMed:18922472, PubMed:21303910). Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex (PubMed:11158321). Interacts with SFMBT2 (PubMed:23385818). Found in a complex with SMAD1 and SMAD4 (PubMed:15329343). Found in a complex with YY1, SIN3A and HDAC1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for YY1 Gene

neXtProt entry for YY1 Gene

Post-translational modifications for YY1 Gene

  • Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites.
  • Ubiquitinated.
  • Ubiquitination at Lys 332
  • Modification sites at PhosphoSitePlus

Other Protein References for YY1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YY1 (YY1)
  • Abcam antibodies for YY1

No data available for DME Specific Peptides for YY1 Gene

Domains & Families for YY1 Gene

Gene Families for YY1 Gene

Protein Domains for YY1 Gene

Suggested Antigen Peptide Sequences for YY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25490

UniProtKB/Swiss-Prot:

TYY1_HUMAN :
  • Belongs to the YY transcription factor family.
  • Contains 4 C2H2-type zinc fingers.
Family:
  • Belongs to the YY transcription factor family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with YY1: view

Function for YY1 Gene

Molecular function for YY1 Gene

GENATLAS Biochemistry:
YY1 transcription factor,repressor/activator (Yin Yang) protein,binding to a variety of transcriptor factors,recruiting HDAC2 or HDAC3 for negative regulation of transcription. Interacting with MYC
UniProtKB/Swiss-Prot Function:
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5-CCGCCATNTT-3; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5-GTCT/AGAC-3) within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions).
UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.

Gene Ontology (GO) - Molecular Function for YY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000400 four-way junction DNA binding IDA 18026119
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA,ISS --
GO:0001158 enhancer sequence-specific DNA binding IMP 15329343
GO:0003677 DNA binding IEA,IDA 21729784
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS 1946405
genes like me logo Genes that share ontologies with YY1: view
genes like me logo Genes that share phenotypes with YY1: view

Animal Models for YY1 Gene

MGI Knock Outs for YY1:

Animal Model Products

CRISPR Products

miRNA for YY1 Gene

miRTarBase miRNAs that target YY1

Transcription Factor Targets for YY1 Gene

Selected GeneGlobe predicted Target genes for YY1
Targeted motifs for YY1 Gene
HOMER Transcription Factor Regulatory Elements motif YY1
  • Consensus sequence: CAAGATGGCGGC Submotif: canonical Cell Type: NA

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for YY1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for YY1 Gene

Localization for YY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for YY1 Gene

Nucleus matrix. Note=Associated with the nuclear matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YY1 Gene COMPARTMENTS Subcellular localization image for YY1 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for YY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IMP 22065573
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
GO:0016363 nuclear matrix IEA --
GO:0031011 Ino80 complex IDA 18026119
genes like me logo Genes that share ontologies with YY1: view

Pathways & Interactions for YY1 Gene

genes like me logo Genes that share pathways with YY1: view

SIGNOR curated interactions for YY1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for YY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9857059
GO:0000724 double-strand break repair via homologous recombination IMP 18026119
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1655281
genes like me logo Genes that share ontologies with YY1: view

Drugs & Compounds for YY1 Gene

(19) Drugs for YY1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for YY1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with YY1: view

Transcripts for YY1 Gene

mRNA/cDNA for YY1 Gene

Unigene Clusters for YY1 Gene

YY1 transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for YY1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YY1 Gene

No ASD Table

Relevant External Links for YY1 Gene

GeneLoc Exon Structure for
YY1
ECgene alternative splicing isoforms for
YY1

Expression for YY1 Gene

mRNA expression in normal human tissues for YY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for YY1 Gene

This gene is overexpressed in CD8 Tcells (11.9), Lung (10.6), Blymphocyte (9.6), and Adrenal (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for YY1 Gene



Protein tissue co-expression partners for YY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of YY1 Gene:

YY1

SOURCE GeneReport for Unigene cluster for YY1 Gene:

Hs.388927
genes like me logo Genes that share expression patterns with YY1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YY1 Gene

Orthologs for YY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for YY1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YY1 34
  • 92.51 (n)
  • 93.48 (a)
YY1 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YY1 34
  • 96.5 (n)
  • 99.02 (a)
YY1 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yy1 34
  • 90.78 (n)
  • 92.72 (a)
Yy1 16
Yy1 35
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YY1 34
  • 99.9 (n)
  • 100 (a)
YY1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yy1 34
  • 90.92 (n)
  • 94.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 100 (a)
OneToMany
chicken
(Gallus gallus)
Aves YY1 34
  • 83.09 (n)
  • 85.64 (a)
YY1 35
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.829 34
yy1 34
  • 79.25 (n)
  • 89.22 (a)
African clawed frog
(Xenopus laevis)
Amphibia yy1-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii yy1a 34
  • 78.06 (n)
  • 85.99 (a)
yy1a 35
  • 86 (a)
ManyToMany
yy1b 35
  • 75 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1785 34
fruit fly
(Drosophila melanogaster)
Insecta pho 36
  • 93 (a)
phol 36
  • 64 (a)
pho 35
  • 30 (a)
ManyToMany
phol 35
  • 20 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2999 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for YY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for YY1 Gene

ENSEMBL:
Gene Tree for YY1 (if available)
TreeFam:
Gene Tree for YY1 (if available)

Paralogs for YY1 Gene

Pseudogenes.org Pseudogenes for YY1 Gene

genes like me logo Genes that share paralogs with YY1: view

Variants for YY1 Gene

Sequence variations from dbSNP and Humsavar for YY1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_065086 -
VAR_074172 -
rs2400876 -- 100,259,335(+) CCAAC(A/G)TGGTG intron-variant
rs2478494 -- 100,271,846(+) gcttt(A/C)ttgcc intron-variant
rs2478495 -- 100,271,853(+) tgccc(A/C)ggctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YY1 Gene

Variant ID Type Subtype PubMed ID
dgv3895n54 CNV gain 21841781
dgv3896n54 CNV loss 21841781
dgv3897n54 CNV gain 21841781
esv22463 CNV loss 19812545
esv2749105 CNV deletion 23290073
esv2749106 CNV deletion 23290073
esv2749108 CNV deletion 23290073
esv3635496 CNV gain 21293372
esv3635502 CNV gain 21293372
nsv1070236 CNV deletion 25765185
nsv1131073 CNV deletion 24896259
nsv565776 CNV loss 21841781
nsv565778 CNV gain 21841781
nsv827052 CNV gain 20364138
nsv827054 CNV gain 20364138
nsv832875 CNV loss 17160897
nsv983854 CNV duplication 23825009

Variation tolerance for YY1 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YY1 Gene

Human Gene Mutation Database (HGMD)
YY1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
YY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YY1 Gene

Disorders for YY1 Gene

Relevant External Links for YY1

Genetic Association Database (GAD)
YY1
Human Genome Epidemiology (HuGE) Navigator
YY1
Tumor Gene Database (TGDB):
YY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YY1

No disorders were found for YY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YY1 Gene

Publications for YY1 Gene

  1. YY1's longer DNA-binding motifs. (PMID: 18950698) Kim J. … Kim J. (Genomics 2009) 3 4 22 65
  2. YY1 functions with INO80 to activate transcription. (PMID: 17721549) Cai Y. … Conaway J.W. (Nat. Struct. Mol. Biol. 2007) 3 4 22 65
  3. Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PMID: 9016636) Kalenik J.L. … Lee T.-C. (Nucleic Acids Res. 1997) 3 4 22 65
  4. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. (PMID: 1655281) Shi Y. … Shenk T. (Cell 1991) 2 3 4 65
  5. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. (PMID: 1946405) Park K. … Atchison M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 22 65

Products for YY1 Gene

Sources for YY1 Gene

Content