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YY1 Gene

protein-coding GIFtS: 68

GC14P099774

YY1 transcription factor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DELTA ^¹, ²
INO80S ^¹, ², ³
NF-E1 ^¹, ², ³
UCRBP ^¹, ²
YIN-YANG-1 ^¹, ²
YY-1 ^³

Descriptions
Delta transcription factor ^³
INO80 complex subunit S ^², ³
YY1 transcription factor ^²
Yin and Yang 1 protein ^²
Yin and yang 1 ^³

External Ids
HGNC: 12856¹
Entrez Gene: 7528²
UniProtKB: P25490³
Ensembl: ENSG00000100811⁷

Search outside databases for aliases for YY1 gene

Previous GC identifers: GC14P098216 GC14P094520 GC14P098695

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YY1:

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc

finger proteins. The protein is involved in repressing and activating a diverse number of

promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in

order to activate or repress the promoter, thus implicating histone modification in the function

of YY1. [provided by RefSeq]

UniProtKB/Swiss-Prot: TYY1_HUMAN, P25490

Function: Multifunctional transcription factor that exhibits positive and negative control on a

large number of cellular and viral genes by binding to sites overlapping the transcription start

site. May play an important role in development and differentiation. The function of YY1 as an

activator or a repressor is specified by the presence of other proteins. For example it acts as a

repressor in absence of adenovirus E1A protein but as an activator in its presence

Gene Wiki entry for YY1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YY1 gene

Entrez Gene cytogenetic band: 14q Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q

YY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P099774: (about GC identifiers)

Start:	99,774,855 bp from pter
End:	99,814,557 bp from pter
Size:	39,703 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TYY1_HUMAN, P25490 (See protein sequence)

Recommended Name: Transcriptional repressor protein YY1

Size: 414 amino acids; 44713 Da

Subunit: Interacts with YAF2 through the region encompassing the first and second zinc fingers.

Interacts with INO80

Subcellular location: Nucleus matrix. Note=Associated with the nuclear matrix

PDB structure from and Proteopedia :

1UBD (3D)

1ZNM (3D)

Secondary accessions: Q14935

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003394.1

ENSEMBL proteins:

ENSP00000262238

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (YY1)
	Human Recombinant Proteins from Abnova (YY1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005667	transcription factor complex	IEA	--
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IDA	18029348

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Antibodies for YY1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for YY1
	R&D Systems Antibodies for YY1
	Cell Signaling Technology (CST) Antibodies for YY1
	Antibodies from Abcam (YY1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YY1)
	Novus Biologicals Antibodies for YY1

Assays for YY1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P25490

ProtoNet protein and cluster: P25490

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: TYY1_HUMAN, P25490

Similarity: Belongs to the YY transcription factor family

Similarity: Contains 4 C2H2-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YY1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003403

Applied Biosystems Silencer® siRNAs for YY1

Sigma-Aldrich siRNA for YY1

Sigma-Aldrich shRNA for YY1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YY1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003403
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003403
untagged cDNA clone in CMV expression vector: NM_003403

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003403

UniProtKB/Swiss-Prot: TYY1_HUMAN, P25490

Function: Multifunctional transcription factor that exhibits positive and negative control on a

large number of cellular and viral genes by binding to sites overlapping the transcription start

site. May play an important role in development and differentiation. The function of YY1 as an

activator or a repressor is specified by the presence of other proteins. For example it acts as a

repressor in absence of adenovirus E1A protein but as an activator in its presence

Genatlas biochemistry entry for YY1:

YY1 transcription factor,repressor/activator (Yin Yang) protein,binding to a variety of

transcriptor factors,recruiting HDAC2 or HDAC3 for negative regulation of transcription.

Interacting with MYC

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Yy1):

cellular	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
nervous system	normal	respiratory system	skin/coat/nails

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	1946405
GO:0003713	transcription coactivator activity	TAS	1946405
GO:0003714	transcription corepressor activity	TAS	1655281
GO:0005515	protein binding	IPI	9016636
GO:0008270	zinc ion binding	TAS	1655281

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for YY1 (Your Favorite Gene powered by Ingenuity)

VDR/RXR Activation

GeneDecks YY1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for YY1

5/113 Interacting proteins for YY1 (P25490^{1, 2} ENSP00000262238³) via UniProtKB, MINT, and/or STRING (see all 113 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YAF2	Q8IY57², ENSP00000328004³	MINT-15247 MINT-15246 STRING (score=.953)
Rybp Rybp (xeno)	Q8CCI5¹	EBI-765538, EBI-929290
EP300	ENSP00000263253³	STRING (score=.999)
HDAC2	ENSP00000357621³	STRING (score=.999)
HDAC1	ENSP00000362649³	STRING (score=.998)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	1655281
GO:0009952	anterior/posterior pattern formation	IEA	--
GO:0048593	camera-type eye morphogenesis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for YY1
10/15 Novoseek chemical compound relationships for YY1 gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	57.49	54	9199306 (2), 15087442 (2), 16865673 (2), 8134108 (2) (see all 34)
atpa	41.97	7	8882641 (4), 9840809 (2)
hpvs	28.62	1	9557642 (1)
steroid	17.39	1	9238849 (1)
sterol	13.61	2	10318878 (1), 9712863 (1)
oligonucleotide	9.73	9	8114709 (2), 10022610 (1), 8524292 (1), 8882641 (1) (see all 7)
thymidine	7.15	2	10022610 (1), 8137827 (1)
glucose	2.24	2	12588874 (2)
atp	0.00	1	8882641 (1)
lysine	0.00	1	11850427 (1)

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2 PharmGKB drug compound relationships for YY1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YY1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003403

Sigma-Aldrich siRNA for YY1

Sigma-Aldrich shRNA for YY1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003403

REFSEQ mRNAs for YY1 gene:

NM_003403.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003403

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003403
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003403
                                 untagged cDNA clone in CMV expression vector: NM_003403

Additional cDNA sequence:

AF147416.1 AK025731.1 AK026497.1 BC014138.2 BC020324.1 BC037308.1 BC051735.1 BC065366.1

BX647456.1 CR592603.1 CR611552.1 M76541.1 M77698.1 Z14077.1

19 DOTS entries:

DT.99968873 DT.97783673 DT.454649 DT.97859625 DT.91896772 DT.100036764 DT.120772238 DT.445428

DT.99945655 DT.40119043 DT.87078356 DT.109199 DT.120772338 DT.438109 DT.92394371 DT.100756454

DT.100804359 DT.100830714 DT.92450425

24/829 AceView cDNA sequences (see all 829 ):

BE672652 BG149828 AI817036 BF061123 BM709955 CB070329 AI268411 BF056850

AI472042 AW137178 Z45953 AI612756 BE675134 BM769953 D11998 H26409

CB241815 BE675659 AI524113 D11996 AI760382 AA442032 BF055094 AW272743

highest scoring ESTs for YY1:

M77698 AA039452 AA079848 AA128758 AA159300 AA279716 AA280760 AA282297 AA283923 AA287777

Unigene Cluster for YY1:

YY1 transcription factor

Hs.388927 [show with all ESTs]

Unigene Representative Sequence: BX647456

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000262238

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YY1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YY1

¹ / ² / ³

14 probe-sets matching YY1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44692_at²^{, 3}	U95-B	1	1.00	1.00	0.59	1.35	AI670903	0.40	1.00	0.76	1
891_at²^{, 3}	U95-A	2	1.00	0.78	0.61	1.19	M77698	1.00	1.00	1.00	1
48339_at²^{, 3}	U95-B	1	0.88	1.00	0.59	0.47	R11821	0.20	1.00	0.72	1
33209_at²^{, 3}	U95-A	1	0.75	1.00	0.25	0.17	M77698	1.00	1.00	1.00	1
224711_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI670903	0.40	1.00	0.76	1
224718_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK025731	0.40	1.00	0.76	1
201901_s_at²^{, 3}	U133-A	3	1.00	0.91	--	--	Z14077	0.80	1.00	0.91	1
200047_s_at²^{, 3}	U133-B	3	1.00	0.80	--	--	NM_003403	0.60	1.00	0.82	1
201902_s_at²^{, 3}	U133-A	1	0.91	1.00	--	--	BG390664	0.40	1.00	0.76	1
224711_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224718_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201901_s_at²	U133Plus2	3	1.00	0.91	--	--	--	--	--	--	--
200047_s_at²	U133Plus2	3	1.00	0.80	--	--	--	--	--	--	--
201902_s_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAACAGAAAG

SOURCE GeneReport for Unigene cluster: Hs.388927
Expression variation in blood from EXPOLDB for YY1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YY1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YY1¹	--	YY1 transcription factor	96.59(n) 99.02(a)	611171 XM_863445.1 XP_868538.1
chimpanzee (Pan troglodytes)	YY1¹	--	YY1 transcription factor	98.23(n) 97.34(a)	453159 XM_510162.2 XP_510162.2
cow (Bos taurus)	YY1¹	--	YY1 transcription factor	96.97(n) 99.09(a)	534353 XM_614101.3 XP_614101.3
rat (Rattus norvegicus)	Yy1¹	--	YY1 transcription factor	94.08(n) 98.78(a)	24919 NM_173290.1 NP_775412.1
mouse (Mus musculus)	Yy1^{1, 5}	12 (53.00 cM)⁵	YY1 transcription factor^{1, 5}	95.55(n)¹ 99.51(a)¹	22632¹ NM_009537.3¹ NP_033563.2¹ AI427614⁵ AK076149⁵ (see all 17)

About this table Species with no ortholog for YY1

ENSEMBL Gene Tree for YY1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YY1 gene

YY2² ZFP42² GLI1²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/240 NCBI SNPs in YY1 are shown (see all 240 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9333573^1,2	A,C,F	99773766(+)	`TAAGGC/TAAATT`	1	--	ng5¹		3	EU NA	388
--	rs9333572^1,2	F	99773124(+)	`GGGTT-/TAATTC`	1	--	ng5¹ tfbs³		1	EU	206
--	rs1051870^1,2	F	99813846(-)	`TTTTTA/TTTTTT`	1	--	ut3¹		1	MN	184
--	rs3209634^1,2	H	99812702(-)	`TGGTGT/CCGTTT`	1	R/R	syn¹ ese³		5	MN EU EA WA	602
	rs1951521^1,2	A,C,F,H,O	99813174(-)	`AACCAT/CGTTAG`	1	--	int¹		11	NA EA MN EU WA	989
	rs4905941^1,2	A,C,F,H	99795191(+)	`TTACTA/GCTTTT`	1	--	int¹		8	EU EA WA NA	628
	rs2146103^1,2	A,C,F,H	99809982(-)	`GTTTGG/TTAACT`	1	--	int¹		11	EU EA WA NA	978
	rs8021068^1,2	A,C,F,H	99808485(+)	`TAAGTG/AATAGT`	1	--	int¹		4	EU EA WA	420
	rs4905942^1,2	A,C,F,H	99810657(+)	`TTTCTC/GCTTCA`	1	--	int¹		7	NA EU EA WA	556
	rs2077216^1,2	A,C,F,H	99799947(+)	`TGGGCG/ATTAAG`	1	--	int¹		7	EU EA WA NA	558

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HapMap Linkage Disequilibrium images for YY1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600013

10/23 Novoseek disease relationships for YY1 gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	29.80	10	11118439 (5), 12588874 (1)
cervical cancer	23.91	10	10385547 (3), 7927871 (1), 10466808 (1), 12526319 (1) (see all 6)
osteosarcoma	23.66	9	16962318 (3), 18488713 (3), 18339860 (2)
tumors	16.92	38	16784892 (4), 18218085 (4), 16314846 (3), 10385547 (3) (see all 20)
cancer	16.79	20	18218085 (2), 19342874 (2), 15870067 (1), 16314846 (1) (see all 12)
carcinoma embryonal	7.86	1	16003908 (1)
hypertrophy	7.10	4	18632988 (2)
invasive cancer	1.50	1	10385547 (1)
cervical intraepithelial neoplasia	0.28	2	17549406 (2)
neurological disorders	0.00	1	18485096 (1)

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1 PharmGKB disease relationship for YY1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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Tumor Gene Database: YY1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/311 PubMed articles for YY1 gene (see all 311 ):

Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. (PubMed id 1655281)^{2, 3, 4} Shi Y.... Shenk T. (1991)
Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site. (PubMed id 1946405)^{1, 3, 4} Park K. and Atchison M. (1991)
YY1 functions with INO80 to activate transcription. (PubMed id 17721549)^{1, 3, 4} Cai Y....Conaway J.W. (2007)
Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1. (PubMed id 9016636)^{1, 3, 4} Kalenik J.L.... Lee T.-C. (1997)
Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. (PubMed id 8942976)^{1, 3, 4} Houbaviy H.B.... Burley S.K. (1996)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Design, synthesis and structure of a zinc finger with an artificial beta-turn. (PubMed id 9642075)^{3, 4} Viles J.H.... Thornton J.M. (1998)
Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking. (PubMed id 9493912)^{3, 4} McNeil S.... Stein G.S. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7528	HGNC: 12856	AceView: YY1	Ensembl:ENSG00000100811	euGenes: HUgn7528
ECgene: YY1	H-InvDB: YY1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for YY1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for YY1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YY1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YY1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YY1		Antibodies for YY1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YY1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YY1)
	Antibodies (YY1)
	Chimera RNAi (YY1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for YY1

	Recombinant Proteins (YY1)
	Antibodies (YY1)

Search OriGene for YY1

Search Tocris compounds for YY1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YY1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
YY1 Gene at Home site.
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YY1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for YY1

Summaries
for YY1

Genomic Location
for YY1

Proteins
for YY1

Protein Domains/
Families
for YY1

Gene Function
for YY1

Pathways & Interactions
for YY1

Drugs & Compounds
for YY1

Transcripts
for YY1

Expression
for YY1

Orthologs
for YY1

Paralogs
for YY1

SNPs/Variants
for YY1

Disorders & Mutations
for YY1

Medical News
for YY1

Publications
for YY1

Search for YY1

Genome Databases showing YY1

Other Databases showing YY1

Specialized Databases showing YY1

Licensable Technologies
for YY1

Services
for YY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YY1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor YY1

Summariesfor YY1

Genomic Locationfor YY1

Proteinsfor YY1

Protein Domains/Familiesfor YY1

Gene Functionfor YY1

Pathways & Interactionsfor YY1

Drugs & Compoundsfor YY1

Transcriptsfor YY1

Expression for YY1

Orthologsfor YY1

Paralogsfor YY1

SNPs/Variantsfor YY1

Disorders & Mutationsfor YY1

Medical Newsfor YY1

Publicationsfor YY1

Search for YY1

Genome Databases showing YY1

Other Databases showing YY1

Specialized Databases showing YY1

Licensable Technologiesfor YY1

Servicesfor YY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YY1

Summaries
for YY1

Genomic Location
for YY1

Proteins
for YY1

Protein Domains/
Families
for YY1

Gene Function
for YY1

Pathways & Interactions
for YY1

Drugs & Compounds
for YY1

Transcripts
for YY1

Expression
for YY1

Orthologs
for YY1

Paralogs
for YY1

SNPs/Variants
for YY1

Disorders & Mutations
for YY1

Medical News
for YY1

Publications
for YY1

Licensable Technologies
for YY1

Services
for YY1