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Aliases for YWHAZ Gene

Aliases for YWHAZ Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Delta Polypeptide 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide 2 3
  • Protein Kinase C Inhibitor Protein 1 3 4
  • 14-3-3 Delta 2 3
  • 14-3-3 Zeta 2 3
  • KCIP-1 3 4
  • Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta Polypeptide 3
  • 14-3-3 Protein/Cytosolic Phospholipase A2 3
  • Protein Kinase C Inhibitor Protein-1 3
  • Epididymis Secretory Protein Li 3 3
  • Epididymis Luminal Protein 4 3
  • Phospholipase A2 3
  • 14-3-3-Zeta 3
  • HEL-S-3 3
  • YWHAD 3
  • HEL4 3

External Ids for YWHAZ Gene

Previous HGNC Symbols for YWHAZ Gene

  • YWHAD

Previous GeneCards Identifiers for YWHAZ Gene

  • GC08M100936
  • GC08M101999
  • GC08M101599
  • GC08M101887
  • GC08M102000
  • GC08M101930
  • GC08M097128

Summaries for YWHAZ Gene

Entrez Gene Summary for YWHAZ Gene

  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for YWHAZ Gene

YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta) is a Protein Coding gene. Diseases associated with YWHAZ include gerstmann-straussler disease and akinetic mutism. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is YWHAE.

UniProtKB/Swiss-Prot for YWHAZ Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Tocris Summary for YWHAZ Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAZ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAZ Gene

Genomics for YWHAZ Gene

Regulatory Elements for YWHAZ Gene

Transcription factor binding sites by QIAGEN in the YWHAZ gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for YWHAZ Gene

Chromosome:
8
Start:
100,916,525 bp from pter
End:
100,954,596 bp from pter
Size:
38,072 bases
Orientation:
Minus strand

Genomic View for YWHAZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YWHAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAZ Gene

Proteins for YWHAZ Gene

  • Protein details for YWHAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63104-1433Z_HUMAN
    Recommended name:
    14-3-3 protein zeta/delta
    Protein Accession:
    P63104
    Secondary Accessions:
    • A8K1N0
    • B7Z465
    • P29213
    • P29312
    • Q32P43
    • Q5XJ08
    • Q6GPI2
    • Q6IN74
    • Q6NUR9
    • Q6P3U9
    • Q86V33

    Protein attributes for YWHAZ Gene

    Size:
    245 amino acids
    Molecular mass:
    27745 Da
    Quaternary structure:
    • Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2.
    SequenceCaution:
    • Sequence=AAH51814.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH73141.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YWHAZ Gene

    Alternative splice isoforms for YWHAZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YWHAZ Gene

Proteomics data for YWHAZ Gene at MOPED

Post-translational modifications for YWHAZ Gene

  • The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.
  • Ubiquitination at Lys 3, Lys 9, Lys 11, Lys 49, and Lys 139
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YWHAZ (14-3-3 zeta)

No data available for DME Specific Peptides for YWHAZ Gene

Domains & Families for YWHAZ Gene

Protein Domains for YWHAZ Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P63104

UniProtKB/Swiss-Prot:

1433Z_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAZ: view

Function for YWHAZ Gene

Molecular function for YWHAZ Gene

GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3
UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Gene Ontology (GO) - Molecular Function for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7935795
GO:0008134 transcription factor binding IPI 16114898
GO:0016301 kinase activity --
GO:0019901 protein kinase binding IPI 10102273
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with YWHAZ: view
genes like me logo Genes that share phenotypes with YWHAZ: view

miRNA for YWHAZ Gene

miRTarBase miRNAs that target YWHAZ

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YWHAZ

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for YWHAZ Gene

Localization for YWHAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAZ Gene

Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YWHAZ Gene COMPARTMENTS Subcellular localization image for YWHAZ gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with YWHAZ: view

Pathways & Interactions for YWHAZ Gene

genes like me logo Genes that share pathways with YWHAZ: view

PCR Array Products

SIGNOR curated interactions for YWHAZ Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006605 protein targeting IEA --
GO:0006915 apoptotic process TAS --
GO:0007165 signal transduction TAS 16130169
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with YWHAZ: view

Drugs & Compounds for YWHAZ Gene

(1) Drugs for YWHAZ Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zolpidem Approved Pharma Full agonist, Allosteric regulator 91

(3) Additional Compounds for YWHAZ Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sepiapterin
  • (S)-2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-Pteridinone
  • 1-(2-Amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-2-hydroxy-1-Propanone
  • 2-Amino-6-(S)-lactoyl-7,8-dihydro-4(3H)-pteridinone
  • 2-Amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)Pteridinone
  • L-Sepiapterin
17094-01-8
Difopein
396834-58-5
R18
211364-78-2
genes like me logo Genes that share compounds with YWHAZ: view

Transcripts for YWHAZ Gene

Unigene Clusters for YWHAZ Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for YWHAZ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAZ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2:
SP3: - - - - - - - -
SP4:
SP5:
SP6: -
SP7: -

Relevant External Links for YWHAZ Gene

GeneLoc Exon Structure for
YWHAZ
ECgene alternative splicing isoforms for
YWHAZ

Expression for YWHAZ Gene

mRNA expression in normal human tissues for YWHAZ Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YWHAZ Gene



SOURCE GeneReport for Unigene cluster for YWHAZ Gene Hs.492407

genes like me logo Genes that share expression patterns with YWHAZ: view

Protein tissue co-expression partners for YWHAZ Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YWHAZ Gene

Orthologs for YWHAZ Gene

This gene was present in the common ancestor of animals.

Orthologs for YWHAZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YWHAZ 35
  • 97.69 (n)
  • 100 (a)
YWHAZ 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YWHAZ 35
  • 97.69 (n)
  • 100 (a)
YWHAZ 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ywhaz 35
  • 92.93 (n)
  • 99.59 (a)
Ywhaz 16
Ywhaz 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YWHAZ 35
  • 99.86 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Ywhaz 35
  • 92.93 (n)
  • 99.59 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia YWHAZ 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves YWHAZ 35
  • 91.56 (n)
  • 99.18 (a)
YWHAZ 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YWHAZ 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75570 35
ywhaz 35
  • 82.45 (n)
  • 90.61 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb33b01 35
ywhabl 35
  • 73.33 (n)
  • 81.63 (a)
ywhaz 36
  • 78 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zgr 37
  • 81 (a)
14-3-3zeta 35
  • 70.75 (n)
  • 80.82 (a)
14-3-3zeta 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007643 35
  • 67.62 (n)
  • 78.78 (a)
worm
(Caenorhabditis elegans)
Secernentea ftt-2 35
  • 70.95 (n)
  • 81.74 (a)
ftt-2 36
  • 79 (a)
ManyToMany
par-5 36
  • 76 (a)
ManyToMany
Species with no ortholog for YWHAZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAZ Gene

ENSEMBL:
Gene Tree for YWHAZ (if available)
TreeFam:
Gene Tree for YWHAZ (if available)

Paralogs for YWHAZ Gene

Paralogs for YWHAZ Gene

genes like me logo Genes that share paralogs with YWHAZ: view

Variants for YWHAZ Gene

Sequence variations from dbSNP and Humsavar for YWHAZ Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs964917 -- 100,925,227(-) TTAAA(A/G)TATTG intron-variant
rs964919 -- 100,925,142(-) GTGTT(A/T)AAGTT intron-variant
rs983583 -- 100,949,682(-) CACTT(A/G)TAAAT intron-variant
rs1062376 -- 100,918,921(-) TGGGG(C/G)TAAGT utr-variant-3-prime
rs1062382 -- 100,918,901(-) AGCTC(A/C)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YWHAZ Gene

Variant ID Type Subtype PubMed ID
nsv831409 CNV Loss 17160897
nsv508521 CNV Loss 20534489

Variation tolerance for YWHAZ Gene

Residual Variation Intolerance Score: 38.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YWHAZ Gene

HapMap Linkage Disequilibrium report
YWHAZ
Human Gene Mutation Database (HGMD)
YWHAZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAZ Gene

Disorders for YWHAZ Gene

MalaCards: The human disease database

(7) MalaCards diseases for YWHAZ Gene - From: DISEASES

Disorder Aliases PubMed IDs
gerstmann-straussler disease
  • cerebral amyloid angiopathy, prnp-related
akinetic mutism
  • coma vigilans
insomnia, fatal familial
  • fatal familial insomnia
post-vaccinal encephalitis
  • post-vaccinal encephalomyelitis
agraphia
- elite association
Search YWHAZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for YWHAZ

Genetic Association Database (GAD)
YWHAZ
Human Genome Epidemiology (HuGE) Navigator
YWHAZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YWHAZ
genes like me logo Genes that share disorders with YWHAZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAZ Gene

Publications for YWHAZ Gene

  1. Selection of reliable reference genes for qPCR studies on chondroprotective action. (PMID: 17324259) Toegel S. … Viernstein H. (BMC Mol. Biol. 2007) 23 67
  2. [Identification of differentially expressed genes in endometrium during the window of implantation using suppression substractive hybridization]. (PMID: 17537306) DU G.P. … Zhou J.P. (Zhonghua Fu Chan Ke Za Zhi 2007) 23 67
  3. An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population. (PMID: 15363479) Jia Y. … Shen Y. (Eur. Psychiatry 2004) 23 67
  4. Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. (PMID: 8617504) Tommerup N. … Leffers H. (Genomics 1996) 2 67
  5. 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. (PMID: 7890696) Aitken A. … Patel Y. (J. Biol. Chem. 1995) 2 67

Products for YWHAZ Gene

Sources for YWHAZ Gene

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