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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAZ Gene

protein-coding   GIFtS: 68
GCID: GC08M101930

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAD)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Zeta Polypeptide1 2
     14-3-3 Protein Zeta/Delta2
YWHAD1 2     14-3-3 Protein/Cytosolic Phospholipase A22
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Delta Polypeptide1 2
     14-3-3-zeta2
14-3-3 Delta1 2     Phospholipase A22
14-3-3 Zeta1 2     Protein Kinase C Inhibitor Protein-12
Protein Kinase C Inhibitor Protein 12 3     Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta
Polypeptide2
KCIP-12 3     

External Ids:    HGNC: 128551   Entrez Gene: 75342   Ensembl: ENSG000001649247   OMIM: 6012885   UniProtKB: P631043   

Export aliases for YWHAZ gene to outside databases

Previous GC identifers: GC08M100936 GC08M101999 GC08M101599 GC08M101887 GC08M102000 GC08M097128


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAZ Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1
protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5'
UTR but that encode the same protein have been identified for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for YWHAZ Gene: 
YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a protein-coding gene. Diseases associated with YWHAZ include paranoid schizophrenia, and balanitis, and among its related super-pathways are Cell cycle and Signal transduction AKT signaling. GO annotations related to this gene include protein complex binding and transcription factor binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

summary for YWHAZ Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAZ gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYWHAZ promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

YWHAZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAZ gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M101930:  view genomic region     (about GC identifiers)

Start:
101,928,753 bp from pter      End:
101,965,623 bp from pter
Size:
36,871 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104 (See protein sequence)
Recommended Name: 14-3-3 protein zeta/delta  
Size: 245 amino acids; 27745 Da
Subunit: Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1
(By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By
similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity).
Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58.
Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated
form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated
phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited
when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional
activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts
with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated
AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and
acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent
thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates
dimerization. Interacts with GAB2 and TLK2
Subcellular location: Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes
Caution: Was originally (PubMed:1577711) thought to have phospholipase A2 activity
Sequence caution: Sequence=AAH51814.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH73141.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/12 PDB 3D structures from and Proteopedia for YWHAZ (see all 12):
1IB1 (3D)        1QJA (3D)        1QJB (3D)        2C1J (3D)        2C1N (3D)        2O02 (3D)    
Secondary accessions: A8K1N0 B7Z465 P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9
Q86V33
Alternative splicing: 2 isoforms:  P63104-1   P63104-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YWHAZ: NX_P63104

Explore proteomics data for YWHAZ at MOPED 

Post-translational modifications:

  • UniProtKB: The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation
    on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on
    Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic
    subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and
    heterodimerization with YHAE and TP53
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P63104

  • YWHAZ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YWHAZ Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001129171.1  NP_001129172.1  NP_001129173.1  NP_001129174.1  NP_003397.1  NP_663723.1  

    ENSEMBL proteins: 
     ENSP00000379287   ENSP00000379286   ENSP00000309503   ENSP00000428860   ENSP00000430072  
     ENSP00000429623   ENSP00000428775   ENSP00000379283   ENSP00000379278   ENSP00000379281  
     ENSP00000395114   ENSP00000430058   ENSP00000429041   ENSP00000416551   ENSP00000394880  
     ENSP00000428381   ENSP00000430219   ENSP00000398599   ENSP00000379288  
    Reactome Protein details: P63104
    Human Recombinant Protein Products for YWHAZ: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for YWHAZ (14-3-3 zeta)
    Enzo Life Sciences proteins for YWHAZ
    OriGene Purified Protein for YWHAZ
    OriGene Protein Over-expression Lysate for YWHAZ
    OriGene MassSpec for YWHAZ 
    OriGene Custom Protein Services for YWHAZ
    GenScript Custom Purified and Recombinant Proteins Services for YWHAZ
    Novus Biologicals YWHAZ Proteins
    Novus Biologicals YWHAZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for YWHAZ
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    YWHAZ for ontologies           About GeneDecksing



    YWHAZ Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAZ
    R&D Systems Antibodies for YWHAZ (14-3-3 zeta)
    Cell Signaling Technology (CST) Antibodies for YWHAZ  (14-3-3 zeta)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for YWHAZ
    GenScript Custom Superior Antibodies Services for YWHAZ
    Novus Biologicals YWHAZ Antibodies
    Abcam antibodies for YWHAZ
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for YWHAZ
    LSBio Antibodies in human, mouse, rat for YWHAZ 

    Assay Products for YWHAZ: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YWHAZ
    R&D Systems ELISAs for YWHAZ (14-3-3 zeta)
    GenScript Custom Assay Services for YWHAZ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry P63104

    ProtoNet protein and cluster: P63104

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104
    Similarity: Belongs to the 14-3-3 family


    YWHAZ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433Z_HUMAN, P63104
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

         Genatlas biochemistry entry for YWHAZ:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10026197
    GO:0008134transcription factor binding IPI16114898
    GO:0016301kinase activity ----
    GO:0019901protein kinase binding IPI10102273
    GO:0019904protein domain specific binding IEA--
         
    YWHAZ for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for YWHAZ:
     Decreased cell number and incr  Decreased viability of wild-ty  Decreased viability with pacli  G0/1 arrest 
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YWHAZ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for YWHAZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAZ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAZ 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAZ
    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAZ (see all 121):
    hsa-miR-582-3p hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-1258 hsa-miR-938 hsa-miR-30d hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidYWHAZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for YWHAZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YWHAZ
    Sirion Biotech Customized adenovirus for overexpression of YWHAZ

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for YWHAZ (see all 27)
    OriGene ORF clones in mouse, rat for YWHAZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): YWHAZ (NM_003406)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAZ
    Sirion Biotech Customized lentivirus for stable overexpression of YWHAZ 
                         Customized lentivirus expression plasmids for stable overexpression of YWHAZ 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for YWHAZ
    Search LifeMap BioReagents cell lines for YWHAZ
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAZ


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for YWHAZ About   (see all 61)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    3Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    4Development Slit-Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    5Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for YWHAZ
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-RI signaling
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAZ
        Apoptosis Signaling Pathways

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAZ (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAZ
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAZ
        Insulin Pathway
    Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for YWHAZ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-1 receptor signaling
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/22 BioSystems Pathways for YWHAZ (see all 22)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    IL-5 Signaling Pathway

    5/20        Reactome Pathways for YWHAZ (see all 20)
        Membrane Trafficking
    GP1b-IX-V activation signalling
    Apoptosis
    Intrinsic Pathway for Apoptosis
    Gene Expression


    5/8         Kegg Pathways  (Kegg details for YWHAZ) (see all 8):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Pathogenic Escherichia coli infection


    YWHAZ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/931 Interacting proteins for YWHAZ (P631041, 2, 3 ENSP000003095034) via UniProtKB, MINT, STRING, and/or I2D (see all 931)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPTP106361, 2, 3, ENSP000003408204EBI-347088,EBI-366182 MINT-8009131 MINT-7233346 MINT-7233334 MINT-7233310 MINT-8009145 MINT-7233285 MINT-8009138 MINT-8008750 MINT-7233372 MINT-7233358 MINT-7233384 MINT-7233323 MINT-7233297 I2D: score=4 STRING: ENSP00000340820
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 STRING: ENSP00000352980
    HIST1H4LP628052, 3, ENSP000003482584MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 STRING: ENSP00000348258
    HIST1H4BP628052, 3MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002553histamine secretion by mast cell IEA--
    GO:0006605protein targeting ----
    GO:0006626protein targeting to mitochondrion IEA--
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction TAS16130169

    YWHAZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    2 HMDB Compounds for YWHAZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    SepiapterinL-sepiapterin (see all 8)17094-01-8--
    ZolpidemAmbien (see all 7)82626-48-0--

    Search CenterWatch for drugs/clinical trials and news about YWHAZ / 1433Z

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YWHAZ gene (6 alternative transcripts): 
    NM_001135699.1  NM_001135700.1  NM_001135701.1  NM_001135702.1  NM_003406.3  NM_145690.2  

    Unigene Cluster for YWHAZ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
    Hs.492407  [show with all ESTs]
    Unigene Representative Sequence: NM_145690
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000395957(uc011lhe.1 uc003yjv.2 uc011lhf.1 uc003yjx.2)
    ENST00000395956 ENST00000353245 ENST00000523848 ENST00000522542 ENST00000521309
    ENST00000522819 ENST00000395953 ENST00000395948 ENST00000395951 ENST00000419477
    ENST00000521607 ENST00000480304 ENST00000518736 ENST00000517727 ENST00000521328
    ENST00000418997 ENST00000437293

    miRNA
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    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAZ (see all 121):
    hsa-miR-582-3p hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-1258 hsa-miR-938 hsa-miR-30d hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidYWHAZ 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK091235.1 AK289945.1 AK294647.1 AK296902.1 AK307506.1 AK315867.1 BC003623.2 BC013265.1 
    BC051814.1 BC063824.1 BC068456.1 BC070389.1 BC072426.1 BC073141.1 BC083508.1 BC099904.1 
    BC101483.1 BC108281.1 BC111951.1 DQ185048.1 M86400.1 S79449.1 U28964.1 

    24/61 DOTS entries (see all 61):

    DT.91790906  DT.91831124  DT.92052153  DT.91790845  DT.97856507  DT.99944503  DT.100695674  DT.95296896 
    DT.100695689  DT.100695711  DT.91790795  DT.120929698  DT.100695700  DT.97864496  DT.100695703  DT.100695685 
    DT.91790909  DT.100695696  DT.121024130  DT.100695683  DT.95310558  DT.99947252  DT.86851675  DT.91753182 

    24/1643 AceView cDNA sequences (see all 1643):

    AA305132 BM783874 CB164727 BM829154 BM474475 AU141088 CR611466 CR623456 
    BM764319 BQ962851 F11091 BU677311 AA227876 BQ675131 BQ889291 BU170982 
    BM829082 AA344422 CB054640 AA863052 BM451803 BC072426 CB148096 R51717 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAZ (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                  -     -                                       
    SP2:                                                                                                
    SP3:              -     -     -     -     -     -     -     -                                       
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for YWHAZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAZ expression in normal human tissues (normalized intensities)      YWHAZ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGTGGAAT
    YWHAZ Expression
    About this image


    YWHAZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Myoblasts Mandibular Arch Muscles
             tongue squamous cells   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             platelets   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Limb (Muscoskeletal System)
             Zone Of Polarizing Activity Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Zone Of Polarizing Activity Cells Limb Bud

    See YWHAZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAZ

    SOURCE GeneReport for Unigene cluster: Hs.492407
        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAZ: 
              Parkinson's Disease in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAZ gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhaz1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 92.93(n)1
    99.59(a)1
      15 (14.56 cM)5
    226311  NM_001253805.11  NP_001240734.11 
     367707705 
    chicken
    (Gallus gallus)
    Aves YWHAZ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 91.56(n)
    99.18(a)
      425619  NM_001031343.1  NP_001026514.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAZ6
    Uncharacterized protein
    100(a)
    1 ↔ 1
    4(14559762-14593157)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041235.12   -- 84.51(n)    BC041235.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb33b012 wufb33b01 77.94(n)   321729  BC059441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3
    14-3-3zeta1
    RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more3
    14-3-3zeta1
    81(a)3
    71.43(n)1
    81.22(a)1
      360591  NM_001014515.11  NP_001014515.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-21 Protein FTT-2 70.85(n)
    81.59(a)
      181348  NM_077538.3  NP_509939.1 
    rice
    (Oryza sativa)
    Liliopsida AK103145.12   -- 76.07(n)    AK103145.1 


    ENSEMBL Gene Tree for YWHAZ (if available)
    TreeFam Gene Tree for YWHAZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAZ gene
    YWHAH2  YWHAE2  YWHAB2  YWHAQ2  YWHAG2  SFN2  
    9 SIMAP similar genes for YWHAZ using alignment to 12 protein entries:     1433Z_HUMAN (see all proteins):
    14-3-3 protein    YWHAB    YWHAQ    YWHAH    SFN    YWHAG
    YWHAE/FAM22B fusion    YWHAE/FAM22A fusion    YWHAE

    YWHAZ for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for YWHAZ (see all 11)
    PGOHUM00000256662 PGOHUM00000256681 PGOHUM00000256682 PGOHUM00000256739 PGOHUM00000247105


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/738 SNPs in YWHAZ are shown (see all 738)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs712769281,2
    C--97152004(+) AAAAA-/CATCTCT 6 -- int11Minor allele frequency- CA:0.00NA 2
    rs1425584611,2
    C--101930389(+) AACATG/TGTGAA 6 -- ds50010--------
    rs1509471861,2
    C--101930463(+) CTACTC/TGGGAG 6 -- ds50010--------
    rs69839891,2
    C,F,A--101930496(+) aacccA/Cgcagg 6 -- ds50013Minor allele frequency- C:0.17NA WA 6
    rs1873792921,2
    --101930502(+) GCAGGC/TGGAGG 6 -- ds50010--------
    rs1921232541,2
    --101930575(+) TCCAAA/CAAAAA 6 -- ds50010--------
    rs1112460051,2
    C--101930587(+) AAAAAA/CAACAA 6 -- ds50010--------
    rs1808682041,2
    --101930671(+) ATATAA/TAATTA 6 -- ds50010--------
    rs574861631,2
    C--101930672(+) ATATA-/TATATATATATATA
    /TATATATATATATATA
    ATTAT
    6 -- ds50011NA 2
    rs1851764771,2
    --101930672(+) TATATA/GATTAT 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for YWHAZ (101928753 - 101965623 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for YWHAZ:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831409CNV Loss17160897
    nsv508521CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601288    OMIM disorders: --

    20/33 diseases for YWHAZ (see all 33):    About MalaCards
    paranoid schizophrenia    balanitis    tuberous sclerosis complex    williams-beuren syndrome
    lipodystrophy    tuberous sclerosis    spinocerebellar ataxia    epididymitis
    schizophrenia    oral cancer    rhabdomyosarcoma    ataxia
    insulin resistance    multiple myeloma    ovarian cancer    parkinson's disease
    atherosclerosis    hepatitis c    myeloma    glioblastoma


    YWHAZ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): YWHAZ
    Human Genome Epidemiology (HuGE) Navigator: YWHAZ (4 documents)

    Export disorders for YWHAZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAZ gene, integrated from 9 sources (see all 339):
    (articles sorted by number of sources associating them with YWHAZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Examination of association of genes in the serotonin system to autism. (PubMed id 19184136)1, 4 Anderson B.M....Haines J.L. (2009)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    4. Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk. (PubMed id 18290843)1, 4 Mateo I....Combarros O. (2008)
    5. 14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk. (PubMed id 18319590)1, 4 Mateo I....Combarros O. (2008)
    6. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (2008)
    7. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. (PubMed id 16376338)1, 2 Gu Y.-M.... Lee K.-Y. (2006)
    8. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7534 HGNC: 12855 AceView: YWHAZ Ensembl:ENSG00000164924 euGenes: HUgn7534
    ECgene: YWHAZ Kegg: 7534 H-InvDB: YWHAZ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YWHAZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YWHAZ gene:
    Search GeneIP for patents involving YWHAZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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