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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAZ Gene

protein-coding   GIFtS: 67
GCID: GC08M101930

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAD)
 Explore 32 diseases affiliated with
YWHAZ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for YWHAZ    

Aliases
for YWHAZ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta
Polypeptide1 2
     14-3-3 Protein Zeta/Delta2
KCIP-11 2 3     14-3-3 Protein/Cytosolic Phospholipase A22
14-3-3-Zeta1     14-3-3 Zeta2
YWHAD1 2     Phospholipase A22
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Delta
Polypeptide1 2
     Protein Kinase C Inhibitor Protein-12
Protein Kinase C Inhibitor Protein 12 3     Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta Polypeptide2
14-3-3 Delta2     

External Ids:    HGNC: 128551   Entrez Gene: 75342   Ensembl: ENSG000001649247   OMIM: 6012885   UniProtKB: P631043   

Export aliases for YWHAZ gene to outside databases

Previous GC identifers: GC08M100936 GC08M101999 GC08M101599 GC08M101887 GC08M102000 GC08M097128


Summaries
for YWHAZ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YWHAZ:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this
protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein,
suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that
encode the same protein have been identified for this gene. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner

summary for YWHAZ:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAZ


Genomic Views
for YWHAZ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAZ gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: YWHAZ promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

YWHAZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAZ gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M101930:  view genomic region     (about GC identifiers)

Start:
 101,928,753 bp from pter      End:
 101,965,623 bp from pter
Size:
 36,871 bases      Orientation:
 minus strand

Proteins
for YWHAZ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104 (See protein sequence)
Recommended Name: 14-3-3 protein zeta/delta  
Size: 245 amino acids; 27745 Da
Subunit: Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By
similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity).
Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer.
Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with
FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with
BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to
mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on
Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form
inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction
retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic
activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation
and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction
phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2
Subcellular location: Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes
Caution: Was originally (PubMed:1577711) thought to have phospholipase A2 activity
Sequence caution: Sequence=AAH51814.1; Type=Erroneous initiation; Sequence=AAH73141.1; Type=Erroneous initiation;
6/11 PDB 3D structures from and Proteopedia for YWHAZ (see all 11):
1IB1 (3D)        1QJA (3D)        1QJB (3D)        2C1J (3D)        2C1N (3D)        2O02 (3D)    
Secondary accessions: A8K1N0 P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9 Q86V33

Explore the universe of human proteins at neXtProt for YWHAZ: NX_P63104

Post-translational modifications:

  • The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on
    • Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232;
    inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a
    sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with
    YHAE and TP531
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P63104

    • YWHAZ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001129171.1  NP_001129172.1  NP_001129173.1  NP_001129174.1  NP_003397.1  NP_663723.1  

    ENSEMBL proteins: 
     ENSP00000379287   ENSP00000379286   ENSP00000309503   ENSP00000428860   ENSP00000430072  
     ENSP00000429623   ENSP00000427801   ENSP00000428775   ENSP00000379283   ENSP00000379278  
     ENSP00000379281   ENSP00000395114   ENSP00000430058   ENSP00000429041   ENSP00000416551  
     ENSP00000394880   ENSP00000428381   ENSP00000430219   ENSP00000398599   ENSP00000379288  
    Reactome Protein details: P63104
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for YWHAZ (14-3-3 zeta)
    Enzo Life Sciences proteins for YWHAZ
    OriGene Purified Protein: YWHAZ
    OriGene Protein Over-expression Lysate (see all 7): YWHAZ
    OriGene Custom Protein Services for YWHAZ 
    GenScript Custom Purified and Recombinant Proteins Services for YWHAZ
    Novus Biologicals YWHAZ Proteins
    Novus Biologicals YWHAZ Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for YWHAZ
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion IEA--


    YWHAZ for ontologies           About GeneDecksing



    YWHAZ Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAZ
    R&D Systems Antibodies for YWHAZ (14-3-3 zeta)
    Cell Signaling Technology (CST) Antibodies for YWHAZ  (14-3-3 zeta)
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    Novus Biologicals YWHAZ Antibodies
    Abcam antibodies for YWHAZ 
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    ThermoFisher Antibodies for YWHAZ

    Assay Products for YWHAZ: 
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    GenScript Custom Assay Services for YWHAZ
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for YWHAZ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YWHAZ for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry P63104

    ProtoNet protein and cluster: P63104

    1 Blocks protein family: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104
    Similarity: Belongs to the 14-3-3 family


    Function
    for YWHAZ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
    Binding generally results in the modulation of the activity of the binding partner

         Genatlas biochemistry entry for YWHAZ:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAZ
    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAZ (see all 121):
    hsa-miR-582-3p hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-1258 hsa-miR-938 hsa-miR-30d hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: YWHAZ 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAZ (see all 7)
    OriGene shRNA RFP: YWHAZ
    OriGene siRNA: YWHAZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAZ

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for YWHAZ

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAZ (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAZ (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): YWHAZ (NM_003406)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAZ 

    Cell Line
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    Search LifeMap BioReagents cell lines for YWHAZ

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAZ

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008134transcription factor binding IPI16114898
    GO:0016301kinase activity ----
    GO:0019904protein domain specific binding IEA--
    GO:0032403protein complex binding IEA--


    YWHAZ for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for YWHAZ:
     Decreased cell number and incr  Decreased viability of wild-ty  Decreased viability with pacli  G0/1 arrest 
     Increased G1 DNA content 


    Pathways & Interactions
    for YWHAZ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/59 super-pathways (see all 59) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    2Apoptosis and survival BAD phosphorylation
    		Apoptosis and survival BAD phosphorylation1.00
    		BAD Phosphorylation0.41
    		Apoptosis and survival_BAD phosphorylation0.99
    3Cell cycle_Role of 14-3-3 proteins in cell cycle regulation
    		Cell cycle_Role of 14-3-3 proteins in cell cycle regulation1.00
    		14-3-3 and Cell Cycle Regulation0.45
    		Cell cycle Role of 14-3-3 proteins in cell cycle regulation1.00
    4BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    		Activation of BH3-only proteins0.30
    		Activation of BAD and translocation to mitochondria 0.15
    		Intrinsic Pathway for Apoptosis0.23
    5Immune response_Function of MEF2 in T lymphocytes
    		Immune response_Function of MEF2 in T lymphocytes1.00
    		Immune response Function of MEF2 in T lymphocytes0.90

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for YWHAZ
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-RI signaling
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAZ
        Apoptosis Signaling Pathways

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAZ (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAZ
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAZ
        Insulin Pathway
    Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for YWHAZ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-1 receptor signaling
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/21 BioSystems Pathways for YWHAZ (see all 21) 
        SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways
    IL-3 Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway

    5/21        Reactome Pathways for YWHAZ (see all 21)
        Membrane Trafficking
    GP1b-IX-V activation signalling
    Apoptosis
    Intrinsic Pathway for Apoptosis
    Gene Expression


    4         Kegg Pathways  (Kegg details for YWHAZ):
        Cell cycle
    Oocyte meiosis
    Neurotrophin signaling pathway
    Pathogenic Escherichia coli infection


    YWHAZ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/898 Interacting proteins for YWHAZ (P631041, 2, 3 ENSP000003095034) via UniProtKB, MINT, STRING, and/or I2D (see all 898)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 STRING: ENSP00000352980
    HIST1H4LP628052, 3, ENSP000003482584MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 STRING: ENSP00000348258
    HIST1H4BP628052, 3MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002553histamine secretion by mast cell IEA--
    GO:0006605protein targeting ----
    GO:0006626protein targeting to mitochondrion IEA--
    GO:0007165signal transduction TAS16130169
    GO:0007596blood coagulation TAS--


    YWHAZ for ontologies           About GeneDecksing



    Drugs & Compounds
    for YWHAZ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    2 HMDB Compounds for YWHAZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    SepiapterinL-sepiapterin (see all 8)17094-01-8--
    ZolpidemAmbien (see all 7)82626-48-0--
    Search CenterWatch for drugs/clinical trials and news about YWHAZ / 1433Z 

    Transcripts
    for YWHAZ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for YWHAZ gene (6 alternative transcripts): 
    NM_001135699.1  NM_001135700.1  NM_001135701.1  NM_001135702.1  NM_003406.3  NM_145690.2  

    Unigene Cluster for YWHAZ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
    Hs.492407  [show with all ESTs]
    Unigene Representative Sequence: NM_145690
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000395957(uc011lhe.1 uc003yjv.2 uc011lhf.1 uc003yjx.2)
    ENST00000395956 ENST00000353245 ENST00000523848 ENST00000522542 ENST00000521309
    ENST00000517797 ENST00000522819 ENST00000395953 ENST00000395948 ENST00000395951
    ENST00000419477 ENST00000521607 ENST00000480304 ENST00000518736 ENST00000517727
    ENST00000521328 ENST00000418997

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAZ
    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAZ (see all 121):
    hsa-miR-582-3p hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-1258 hsa-miR-938 hsa-miR-30d hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: YWHAZ 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAZ (see all 7)
    OriGene shRNA RFP: YWHAZ
    OriGene siRNA: YWHAZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAZ
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): YWHAZ (NM_003406)
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    Additional cDNA sequence: 

    AK091235.1 AK289945.1 AK294647.1 AK296902.1 AK307506.1 AK315867.1 BC003623.2 BC013265.1 
    BC051814.1 BC063824.1 BC068456.1 BC070389.1 BC072426.1 BC073141.1 BC083508.1 BC099904.1 
    BC101483.1 BC108281.1 BC111951.1 DQ185048.1 M86400.1 S79449.1 U28964.1 

    24/61 DOTS entries (see all 61):

    DT.91790906  DT.91831124  DT.92052153  DT.91790845  DT.97856507  DT.99944503  DT.100695674  DT.95296896 
    DT.100695689  DT.100695711  DT.91790795  DT.120929698  DT.100695700  DT.97864496  DT.100695703  DT.100695685 
    DT.91790909  DT.100695696  DT.121024130  DT.100695683  DT.95310558  DT.99947252  DT.86851675  DT.91753182 

    24/1643 AceView cDNA sequences (see all 1643):

    BU685990 BX461328 CB266225 AL535845 BX439954 BM694042 BU170501 C04444 
    BM770225 BQ640713 AV709595 BG289939 AA322000 T40149 BQ430685 BG677193 
    CA393032 CD239731 AA329662 CB215935 BQ673299 AA333928 BQ057440 BE856257 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAZ (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                  -     -                                       
    SP2:                                                                                                
    SP3:              -     -     -     -     -     -     -     -                                       
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for YWHAZ

    Expression
    for YWHAZ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGTGGAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    YWHAZ expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudZone Of Polarizing Activity CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See YWHAZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAZ

    SOURCE GeneReport for Unigene cluster: Hs.492407
        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAZ: 
              Parkinson's Disease in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for YWHAZ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAZ gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ywhaz1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 92.93(n)1
    99.59(a)1    		   15 (14.56 cM)5
    226311  NM_001253805.11  NP_001240734.11 
     367707705 
    chicken
    (Gallus gallus)    		 Aves YWHAZ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 91.56(n)
    99.18(a)    		   425619  NM_001031343.1  NP_001026514.1 
    lizard
    (Anolis carolinensis)    		 Reptilia YWHAZ6
    		 --
    		 99(a)
    		 1 ↔ 1
    		 4(14564754-14589292)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC041235.12   -- 84.51(n)    BC041235.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb33b012 wufb33b01 77.94(n)   321729  BC059441.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta 14-3-3&zgr;3
    14-3-3zeta1    		 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more3
    14-3-3zeta1    		 81(a)3
    71.43(n)1
    81.22(a)1    		   360591  NM_001014515.11  NP_001014515.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ftt-21 Protein FTT-2 70.85(n)
    81.59(a)    		   181348  NM_077538.3  NP_509939.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GRF36
    GRF26
    (see all 14)    		 14-3-3-like protein GF14 omega
    (see all 14)    		 61(a)
    59(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 5(15409697-15411516)
    1(29461671-29463385)
    rice
    (Oryza sativa)    		 Liliopsida AK103145.12   -- 76.07(n)    AK103145.1 


    ENSEMBL Gene Tree for YWHAZ (if available)
    TreeFam Gene Tree for YWHAZ (if available) 

    Paralogs
    for YWHAZ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAZ gene
    YWHAE2  YWHAH2  YWHAQ2  YWHAB2  YWHAG2  SFN2  
    9 SIMAP similar genes for YWHAZ using alignment to 12 protein entries:     1433Z_HUMAN (see all proteins):
    14-3-3 protein    YWHAB    YWHAQ    YWHAH    SFN    YWHAG
    YWHAE/FAM22B fusion    YWHAE/FAM22A fusion    YWHAE

    YWHAZ for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for YWHAZ (see all 11)
    PGOHUM00000256662 PGOHUM00000256681 PGOHUM00000256682 PGOHUM00000256739 PGOHUM00000247105


    Genomic Variants
    for YWHAZ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/642 NCBI SNPs in YWHAZ are shown (see all 642)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1425584611,2
    		--101930389(+) AACATG/TGTGAA 6 -- ds50010--------
    rs1509471861,2
    		--101930463(+) CTACTC/TGGGAG 6 -- ds50010--------
    rs69839891,2
    		C,A,--101930496(+) aacccA/Cgcagg 6 -- ds50013Minor allele frequency- C:0.17NA WA 6
    rs1873792921,2
    		--101930502(+) GCAGGC/TGGAGG 6 -- ds50010--------
    rs1921232541,2
    		--101930575(+) TCCAAA/CAAAAA 6 -- ds50010--------
    rs2019102471,2
    		C,--101930586(+) AAAAA-/ACAACAA 6 -- ds50010--------
    rs1112460051,2
    		C--101930587(+) AAAAAA/CAACAA 6 -- ds50010--------
    rs1440545741,2
    		C--101930637(+) TACTT-/TATATATATAT
    ATATATATATATA    TATAT     		6 -- ds50010--------
    rs1808682041,2
    		--101930671(+) ATATAA/TAATTA 6 -- ds50010--------
    rs1851764771,2
    		--101930672(+) TATATA/GATTAT 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for YWHAZ (101928753 - 101965623 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YWHAZ: --

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    Disorders / Diseases
    for YWHAZ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YWHAZ for disorders           About GeneDecksing

    OMIM gene information: 601288    OMIM disorders: --

    20/32 diseases for YWHAZ (see all 32):    About MalaCards
    williams-beuren syndrome    paranoid schizophrenia    spinocerebellar ataxia    conduct disorder
    tuberous sclerosis    epithelial ovarian cancer    insulin resistance    balanitis
    lipodystrophy    hepatitis c    ovarian cancer    epididymitis
    adhd    myeloid leukemia    parkinson's disease    oral cancer
    rhabdomyosarcoma    ataxia    hepatocellular carcinoma    alzheimer's disease

    Human Genome Epidemiology (HuGE) Navigator: YWHAZ (4 documents)

    Export disorders for YWHAZ gene to outside databases

    Publications
    for YWHAZ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAZ gene, integrated from 9 sources (see all 294):
    (articles sorted by number of sources associating them with YWHAZ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    2. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. (PubMed id 16376338)1, 2 Gu Y.-M.... Lee K.-Y. (2006)
    3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)
    6. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PubMed id 16246723)1, 2 Macdonald N.... Mahadevan L.C. (2005)
    7. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2 Soosairajah J.... Bernard O. (2005)
    8. 14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. (PubMed id 16114898)1, 2 Obsilova V.... Obsil T. (2005)
    9. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (2004)
    10. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. (PubMed id 14970201)1, 2 Zenke F.T....Bokoch G.M. (2004)

    External Searches for YWHAZ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing YWHAZ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7534 HGNC: 12855 AceView: YWHAZ Ensembl:ENSG00000164924 euGenes: HUgn7534
    ECgene: YWHAZ Kegg: 7534 H-InvDB: YWHAZ

    Other Databases showing YWHAZ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing YWHAZ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YWHAZ Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for YWHAZ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for YWHAZ gene:
    Search GeneIP for patents involving YWHAZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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