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YWHAZ Gene

protein-coding GIFtS: 69

GC08M102000

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KCIP-1 ^¹, ², ³
MGC111427 ^²
MGC126532 ^²
MGC138156 ^²
OTTHUMP00000165851 ^²
OTTHUMP00000165852 ^²
OTTHUMP00000165854 ^²
OTTHUMP00000165858 ^²
OTTHUMP00000165859 ^²
OTTHUMP00000165860 ^²

Descriptions
14-3-3 protein/cytosolic phospholipase A2 ^²
14-3-3 zeta ^²
Protein kinase C inhibitor protein 1 ^³
phospholipase A2 ^²
protein kinase C inhibitor protein-1 ^²
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide ^²
tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide ^²

External Ids
HGNC: 12855¹
Entrez Gene: 7534²
UniProtKB: P63104³
Ensembl: ENSG00000164924⁷

Search outside databases for aliases for YWHAZ gene

Previous GC identifers: GC08M100936 GC08M101999 GC08M101599 GC08M101887

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YWHAZ:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by

binding to phosphoserine-containing proteins. This highly conserved protein family is found in

both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs.

The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin

sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same

protein have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Gene Wiki entry for YWHAZ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YWHAZ gene

Entrez Gene cytogenetic band: 8q23.1 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3

YWHAZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M102000: (about GC identifiers)

Start:	101,999,980 bp from pter
End:	102,034,745 bp from pter
Size:	34,766 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008046.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104 (See protein sequence)

Recommended Name: 14-3-3 protein zeta/delta

Size: 245 amino acids; 27745 Da

Subunit: Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by

phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with PCTK1 and

BSPRY (By similarity). Interacts with WEE1 (C-terminal) (By similarity). Interacts with MLF1

(phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with

Thr-phosphorylated ITGB2 (By similarity). Interacts with Pseudomonas aeruginosa exoS

(unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress

conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with

phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232.

Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58

phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with

ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT

('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through

preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a

second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with

similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates

dimerization

Subcellular location: Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes

Caution: Was originally (PubMed:1577711) thought to have phospholipase A2 activity

PDB structures from and Proteopedia :

1IB1 (3D)

1QJA (3D)

1QJB (3D)

2C1J (3D)

2C1N (3D)

2O02 (3D)

3CU8 (3D)

Secondary accessions: P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9 Q86V33

Post-translational modifications:

The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity).

Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to

mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization

with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation

on Thr-232; inhibits binding of RAF1¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_001129171.1 NP_001129172.1 NP_001129173.1 NP_001129174.1 NP_003397.1 NP_663723.1

ENSEMBL proteins:

ENSP00000379288 ENSP00000379287 ENSP00000379286 ENSP00000309503 ENSP00000379283 ENSP00000379281

ENSP00000379278

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for YWHAZ (14-3-3 zeta)
	Enzo Life Sciences proteins for YWHAZ
	Recombinant Proteins from Abcam (14-3-3, 14-3-3 zeta, 14-3-3 beta + epsilon + zeta, 14-3-3 eta + gamma + zeta, 14-3-3 beta + zeta)
	Human Recombinant Proteins from Abnova (YWHAZ)

OriGene Purified Recombinant Human Protein: YWHAZ

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	16130169
GO:0005739	mitochondrion	IEA	--
GO:0042470	melanosome	IEA	--

About this table

Antibodies for YWHAZ:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of YWHAZ
	Sigma-Aldrich Antibodies for YWHAZ
	R&D Systems Antibodies for YWHAZ (14-3-3 zeta)
	Antibodies from Abcam (14-3-3, 14-3-3 zeta, 14-3-3 beta + epsilon + zeta, 14-3-3 eta + gamma + zeta, 14-3-3 beta + zeta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YWHAZ)
	Novus Biologicals Antibodies for YWHAZ

Assays for YWHAZ:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P63104

ProtoNet protein and cluster: P63104

1 Blocks protein family: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104

Similarity: Belongs to the 14-3-3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAZ)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_001135699

Applied Biosystems Silencer® siRNAs for YWHAZ

Sigma-Aldrich siRNA for YWHAZ

Sigma-Aldrich shRNA Panels and shRNA for YWHAZ

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YWHAZ
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001135699
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001135699
untagged cDNA clones in CMV expression vector (see all 7): NM_001135699

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003406

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Genatlas biochemistry entry for YWHAZ:

tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008134	transcription factor binding	IPI	16114898
GO:0019904	protein domain specific binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/12 Sigma-Aldrich "Your Favorite Gene" Pathways for YWHAZ (Your Favorite Gene powered by Ingenuity) (see all 12 )

Endothelin-1 Signaling
Cell Cycle: G2/M DNA Damage Checkpoint Regulation
Phospholipid Degradation
ERK/MAPK Signaling
Synaptic Long Term Depression

GeneDecks YWHAZ for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for YWHAZ

5/452 Interacting proteins for YWHAZ (P63104^{1, 2} ENSP00000309503³) via UniProtKB, MINT, and/or STRING (see all 452 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TSC2	P49815², ENSP00000219476³	MINT-16860 MINT-16861 MINT-3294932 MINT-15413 MINT-3294490 MINT-3317863 STRING (score=.996)
CDC25B	P30305², ENSP00000245960³	MINT-19329 MINT-17849 MINT-17850 MINT-25121 STRING (score=.996)
ENSG00000008277	Q9P0K1², ENSP00000265727³	MINT-17974 MINT-17972 MINT-17973 STRING (score=.872)
HDAC4	P56524², ENSP00000264606³	MINT-3296491 MINT-3294610 STRING (score=.896)
RIN1	Q13671², ENSP00000310406³	MINT-17570 MINT-17571 STRING (score=.803)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	IEA	--
GO:0006916	anti-apoptosis	TAS	16130169
GO:0007165	signal transduction	TAS	16130169

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for YWHAZ

Browse Small Molecules at Sigma-Aldrich

Compounds for YWHAZ available from Tocris Bioscience

Compound	Action	CAS number
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAZ)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_001135699

Sigma-Aldrich siRNA for YWHAZ

Sigma-Aldrich shRNA Panels and shRNA for YWHAZ

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001135699 NM_001135700 NM_001135701 NM_001135702 NM_003406 NM_145690

REFSEQ mRNAs for YWHAZ gene (6 alternative transcripts):

NM_001135699.1 NM_001135700.1 NM_001135701.1 NM_001135702.1 NM_003406.3 NM_145690.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001135699 NM_001135700 NM_001135701 NM_001135702 NM_003406 NM_145690

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001135699
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001135699
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_001135699

Additional cDNA sequence:

AK091235.1 AK289945.1 AK294647.1 AK296902.1 AK307506.1 AK315867.1 BC003623.2 BC013265.1

BC051814.1 BC063824.1 BC068456.1 BC070389.1 BC072426.1 BC073141.1 BC083508.1 BC099904.1

BC101483.1 BC108281.1 BC111951.1 CR606956.1 CR607781.1 CR611466.1 CR612878.1 CR614741.1

CR623456.1 CR623658.1 CR624253.1 CR625952.1 DQ185048.1 M86400.1 S79449.1 U28964.1

24/64 DOTS entries (see all 64 ):

DT.91790906 DT.91831124 DT.92052153 DT.91790845 DT.97856507 DT.99944503 DT.100695674 DT.95296896

DT.100695689 DT.100695711 DT.91790795 DT.120929698 DT.100695700 DT.97864496 DT.100695703 DT.100695685

DT.86856467 DT.91790909 DT.100695696 DT.86851675 DT.121024130 DT.100695683 DT.95310558 DT.99947252

24/1643 AceView cDNA sequences (see all 1643 ):

BM783874 BQ229294 AV709595 CB164727 F01886 BU686827 AL533755 BU629938

BG677976 AA961128 BM762508 AU141088 BM993627 BM474475 AA453530 W79212

BM989284 AV725891 BM764319 AA305132 BX439002 CB215935 BX461441 BQ420672

highest scoring ESTs for YWHAZ:

M86400 AA316126 AL560027 BF306804 BG390833 BG754890 BG773300 U28964 BG392263 AA010044

Unigene Cluster for YWHAZ:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Hs.492407 [show with all ESTs]

Unigene Representative Sequence: NM_145690

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAZ (see all 7 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10
SP1:																	-		-
SP2:
SP3:					-		-		-		-		-		-		-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for YWHAZ

7 Ensembl transcripts including schematic representations:

ENST00000395958 ENST00000395957 ENST00000395956 ENST00000353245 ENST00000395953 ENST00000395951

ENST00000395948

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YWHAZ expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YWHAZ

¹ / ² / ³

11 probe-sets matching YWHAZ gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1235_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.04	M86400	1.00	1.00	1.00	1
34642_at²^{, 3}	U95-A	9	1.00	0.42	0.93	0.94	U28964	0.80	1.00	0.91	1
88553_at²^{, 3}	U95-D	1	0.38	1.00	0.95	1.02	AI635224	0.20	1.00	0.72	1
200640_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003406	0.60	1.00	0.82	1
200638_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003623	0.60	1.00	0.82	1
200639_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003406	0.60	1.00	0.82	1
200641_s_at²^{, 3}	U133-A	10	1.00	0.27	--	--	U28964	0.80	1.00	0.91	1
200640_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200638_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200639_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200641_s_at²	U133Plus2	10	1.00	0.27	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAGTGGAAT

SOURCE GeneReport for Unigene cluster: Hs.492407
Expression variation in blood from EXPOLDB for YWHAZ

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YWHAZ gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YWHAZ¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	97.69(n) 100(a)	475864 XM_533072.2 XP_533072.2
chimpanzee (Pan troglodytes)	YWHAZ¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	99.86(n) 100(a)	472830 XM_528202.2 XP_528202.2
cow (Bos taurus)	YWHAZ¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	97.69(n) 100(a)	287022 NM_174814.2 NP_777239.1
rat (Rattus norvegicus)	Ywhaz¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	92.93(n) 99.59(a)	25578 NM_013011.2 NP_037143.2
mouse (Mus musculus)	Ywhaz^{1, 5}	15⁵	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more^{1, 5}	92.93(n)¹ 99.59(a)¹	22631¹ NM_011740.2¹ NP_035870.1¹ AI596267⁵ AK003664⁵ (see all 29)

About this table Species with no ortholog for YWHAZ

ENSEMBL Gene Tree for YWHAZ

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YWHAZ gene

YWHAB² YWHAQ² SFN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/204 NCBI SNPs in YWHAZ are shown (see all 204 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 54)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2290291^1,2	C,F,H	102034076(-)	`CACAAT/CGCCGG`	2	--	ng3¹ int¹		4		EA WA	1766
	rs3757877^1,2	F,H	102035080(+)	`CCTCCG/ATTTAG`	2	--	ng3¹		5		EA EU WA	1898
--	rs3100052^1,2	A,C	102036315(-)	`TAGCTC/TTGAAG`	1	--	ng3¹		0	--	--	--	--
--	rs6983989^1,2	A,C	101999672(+)	`aacccA/Cgcagg`	2	--	ng5¹		0	--	--	--	--
--	rs11551356^1,2	C,F	102000610(-)	`CTGTTT/CTAGCC`	6	--	ut3¹		1		MN	184
--	rs1062382^1,2	F	102000305(-)	`AGCTCA/CCTTTA`	6	--	ut3¹ ese³		1		MN	184
	rs1451637^1,2	H	102034464(-)	`CCTTCC/TAGGCC`	2	--	ng3¹ int¹		5		MN EU EA WA	596
	rs3100053^1,2	A,C,F,H,O	102013735(-)	`AGTTCA/TGAGCT`	2	--	int¹		6		EA WA NA	438
	rs964917^1,2	A,C,F,H,O	102006631(-)	`TTAAAG/ATATTG`	2	--	int¹		15		EA NA EU WA	2476
	rs1470764^1,2	A,C,F,H,O	102019214(-)	`ACTTAT/CTGAGA`	2	--	int¹		20		EU EA WA NA	1834

About this table

HapMap Linkage Disequilibrium images for YWHAZ (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601288

Human Genome Epidemiology Navigator: YWHAZ (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/176 PubMed articles for YWHAZ gene (see all 176 ):

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. (PubMed id 16246723)^{3, 4} Macdonald N.... Mahadevan L.C. (2005)
Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)^{3, 4} Soosairajah J.... Bernard O. (2005)
14-3-3 protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. (PubMed id 16114898)^{3, 4} Obsilova V.... Obsil T. (2005)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{3, 4} Nagata-Ohashi K.... Mizuno K. (2004)
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. (PubMed id 14970201)^{3, 4} Zenke F.T....Bokoch G.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Identification of 14-3-3zeta as a protein kinase B/Akt substrate. (PubMed id 11956222)^{3, 4} Powell D.W....McLeish K.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7534	HGNC: 12855	AceView: YWHAZ	Ensembl:ENSG00000164924	euGenes: HUgn7534
ECgene: YWHAZ	H-InvDB: YWHAZ

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YWHAZ
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YWHAZ:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YWHAZ-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YWHAZ		Antibodies for YWHAZ
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YWHAZ		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YWHAZ)
	Antibodies (YWHAZ)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (14-3-3, 14-3-3 zeta, 14-3-3 beta + epsilon + zeta, 14-3-3 eta + gamma + zeta, 14-3-3 beta + zeta)
	Antibodies (14-3-3, 14-3-3 zeta, 14-3-3 beta + epsilon + zeta, 14-3-3 eta + gamma + zeta, 14-3-3 beta + zeta)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for YWHAZ

	Drugs/Proteins for YWHAZ
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YWHAZ

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
YWHAZ Gene at Home site.
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YWHAZ Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for YWHAZ

Summaries
for YWHAZ

Genomic Location
for YWHAZ

Proteins
for YWHAZ

Protein Domains/
Families
for YWHAZ

Gene Function
for YWHAZ

Pathways & Interactions
for YWHAZ

Drugs & Compounds
for YWHAZ

Transcripts
for YWHAZ

Expression
for YWHAZ

Orthologs
for YWHAZ

Paralogs
for YWHAZ

SNPs/Variants
for YWHAZ

Disorders & Mutations
for YWHAZ

Medical News
for YWHAZ

Publications
for YWHAZ

Search for YWHAZ

Genome Databases showing YWHAZ

Other Databases showing YWHAZ

Specialized Databases showing YWHAZ

Licensable Technologies
for YWHAZ

Services
for YWHAZ

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YWHAZ Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor YWHAZ

Summariesfor YWHAZ

Genomic Locationfor YWHAZ

Proteinsfor YWHAZ

Protein Domains/Familiesfor YWHAZ

Gene Functionfor YWHAZ

Pathways & Interactionsfor YWHAZ

Drugs & Compoundsfor YWHAZ

Transcriptsfor YWHAZ

Expression for YWHAZ

Orthologsfor YWHAZ

Paralogsfor YWHAZ

SNPs/Variantsfor YWHAZ

Disorders & Mutationsfor YWHAZ

Medical Newsfor YWHAZ

Publicationsfor YWHAZ

Search for YWHAZ

Genome Databases showing YWHAZ

Other Databases showing YWHAZ

Specialized Databases showing YWHAZ

Licensable Technologiesfor YWHAZ

Servicesfor YWHAZ

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YWHAZ

Summaries
for YWHAZ

Genomic Location
for YWHAZ

Proteins
for YWHAZ

Protein Domains/
Families
for YWHAZ

Gene Function
for YWHAZ

Pathways & Interactions
for YWHAZ

Drugs & Compounds
for YWHAZ

Transcripts
for YWHAZ

Expression
for YWHAZ

Orthologs
for YWHAZ

Paralogs
for YWHAZ

SNPs/Variants
for YWHAZ

Disorders & Mutations
for YWHAZ

Medical News
for YWHAZ

Publications
for YWHAZ

Licensable Technologies
for YWHAZ

Services
for YWHAZ