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Aliases for YWHAZ Gene

Aliases for YWHAZ Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta 2 3 5
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Delta Polypeptide 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide 2 3
  • 14-3-3 Delta 2 3
  • 14-3-3 Zeta 2 3
  • KCIP-1 3 4
  • Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta Polypeptide 3
  • 14-3-3 Protein/Cytosolic Phospholipase A2 3
  • Protein Kinase C Inhibitor Protein-1 3
  • Protein Kinase C Inhibitor Protein 1 4
  • Epididymis Secretory Protein Li 93 3
  • Epididymis Secretory Protein Li 3 3
  • Epididymis Luminal Protein 4 3
  • 14-3-3 Protein Zeta/Delta 3
  • Phospholipase A2 3
  • 14-3-3-Zeta 3
  • HEL-S-93 3
  • HEL-S-3 3
  • YWHAD 3
  • HEL4 3

External Ids for YWHAZ Gene

Previous HGNC Symbols for YWHAZ Gene


Previous GeneCards Identifiers for YWHAZ Gene

  • GC08M100936
  • GC08M101999
  • GC08M101599
  • GC08M101887
  • GC08M102000
  • GC08M101930
  • GC08M097128

Summaries for YWHAZ Gene

Entrez Gene Summary for YWHAZ Gene

  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for YWHAZ Gene

YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) is a Protein Coding gene. Among its related pathways are DNA Damage and Rap1 signalling. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is YWHAB.

UniProtKB/Swiss-Prot for YWHAZ Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Tocris Summary for YWHAZ Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAZ Gene

Additional gene information for YWHAZ Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAZ Gene

Genomics for YWHAZ Gene

Regulatory Elements for YWHAZ Gene

Enhancers for YWHAZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H100947 1.4 ENCODE dbSUPER 47.7 +3.4 3372 7.8 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN YWHAZ PABPC1 RNF19A ENSG00000260368 GC08M100948 GC08M100949
GH08H100985 1.2 Ensembl ENCODE 46 -32.1 -32053 1.9 HDGF PKNOX1 ARNT ZNF766 GATA2 FOS ZNF592 SNIP1 MEF2D SREBF1 YWHAZ RN7SL685P RNF19A PABPC1 GC08M100962 LOC401471
GH08H100922 0.6 dbSUPER 60.8 +29.1 29128 5.8 SMARCA5 ZNF316 POLR2A IKZF1 MAFG EBF1 IKZF2 MAFK YWHAZ RN7SL685P ENSG00000260368 GC08M100916 GC08M100934
GH08H100899 2 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +53.4 53425 3.6 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZNF766 CBX5 ZNF143 ZNF207 YWHAZ PABPC1 GAPDHP62 ZNF706 ENSG00000275041 ENSG00000260368
GH08H100905 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +46.8 46846 4.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A BRCA1 YY1 GLIS2 FOS RUNX3 YWHAZ ANKRD46 FLJ42969 ZNF706 PABPC1 ENSG00000260368 ENSG00000275041
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around YWHAZ on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the YWHAZ gene promoter:

Genomic Locations for YWHAZ Gene

Genomic Locations for YWHAZ Gene
38,072 bases
Minus strand

Genomic View for YWHAZ Gene

Genes around YWHAZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YWHAZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YWHAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAZ Gene

Proteins for YWHAZ Gene

  • Protein details for YWHAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    14-3-3 protein zeta/delta
    Protein Accession:
    Secondary Accessions:
    • A8K1N0
    • B7Z465
    • P29213
    • P29312
    • Q32P43
    • Q5XJ08
    • Q6GPI2
    • Q6IN74
    • Q6NUR9
    • Q6P3U9
    • Q86V33

    Protein attributes for YWHAZ Gene

    245 amino acids
    Molecular mass:
    27745 Da
    Quaternary structure:
    • Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2. Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1 (PubMed:19640509).
    • Sequence=AAH51814.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH73141.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YWHAZ Gene

    Alternative splice isoforms for YWHAZ Gene


neXtProt entry for YWHAZ Gene

Post-translational modifications for YWHAZ Gene

  • The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.
  • Ubiquitination at isoforms=3, Lys9, isoforms=11, isoforms=49, and isoforms=2139
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YWHAZ (14-3-3 zeta)

No data available for DME Specific Peptides for YWHAZ Gene

Domains & Families for YWHAZ Gene

Gene Families for YWHAZ Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for YWHAZ Gene

Graphical View of Domain Structure for InterPro Entry



1433Z_HUMAN :
  • Belongs to the 14-3-3 family.
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAZ: view

Function for YWHAZ Gene

Molecular function for YWHAZ Gene

GENATLAS Biochemistry:
tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3
UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Phenotypes From GWAS Catalog for YWHAZ Gene

Gene Ontology (GO) - Molecular Function for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0004497 monooxygenase activity IEA --
GO:0005515 protein binding IPI 7935795
GO:0008134 transcription factor binding IPI 16114898
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with YWHAZ: view
genes like me logo Genes that share phenotypes with YWHAZ: view

Animal Models for YWHAZ Gene

MGI Knock Outs for YWHAZ:

miRNA for YWHAZ Gene

miRTarBase miRNAs that target YWHAZ

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for YWHAZ Gene

Localization for YWHAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAZ Gene

Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for YWHAZ gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with YWHAZ: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for YWHAZ Gene

Pathways & Interactions for YWHAZ Gene

genes like me logo Genes that share pathways with YWHAZ: view

Pathways by source for YWHAZ Gene

SIGNOR curated interactions for YWHAZ Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0007165 signal transduction TAS 16130169
GO:0010941 regulation of cell death IEA --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with YWHAZ: view

Drugs & Compounds for YWHAZ Gene

(3) Drugs for YWHAZ Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zolpidem Approved Pharma Full agonist, Allosteric regulator 105
Phenethyl isothiocyanate Investigational Pharma Target 12
R18 Pharma 14.3.3 proteins Antagonist 0

(2) Additional Compounds for YWHAZ Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (S)-2-amino-7,8-dihydro-6-(2-hydroxy-1-oxopropyl)-4(1H)-Pteridinone
  • 1-(2-Amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-2-hydroxy-1-Propanone
  • 2-Amino-6-(S)-lactoyl-7,8-dihydro-4(3H)-pteridinone
  • 2-Amino-7,8-dihydro-6-[(2S)-2-hydroxy-1-oxopropyl]-4(1H)Pteridinone
  • L-Sepiapterin

(2) Tocris Compounds for YWHAZ Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis 396834-58-5
R18 Inhibitor of 14.3.3 proteins 211364-78-2

(1) ApexBio Compounds for YWHAZ Gene

Compound Action Cas Number
R18 14.3.3 proteins Antagonist 211364-78-2
genes like me logo Genes that share compounds with YWHAZ: view

Drug Products

Transcripts for YWHAZ Gene

Unigene Clusters for YWHAZ Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAZ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP3: - - - - - - - -
SP6: -
SP7: -

Relevant External Links for YWHAZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for YWHAZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for YWHAZ Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for YWHAZ Gene

Protein tissue co-expression partners for YWHAZ Gene

NURSA nuclear receptor signaling pathways regulating expression of YWHAZ Gene:


SOURCE GeneReport for Unigene cluster for YWHAZ Gene:


Evidence on tissue expression from TISSUES for YWHAZ Gene

  • Nervous system(5)
  • Intestine(4.9)
  • Skin(4.8)
  • Blood(4.7)
  • Eye(4.7)
  • Liver(4.6)
  • Bone marrow(4.5)
  • Lung(3.7)
  • Kidney(3)
  • Heart(2.7)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Pancreas(2.5)
  • Stomach(2.5)
  • Muscle(2.4)
  • Gall bladder(2.1)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with YWHAZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for YWHAZ Gene

Orthologs for YWHAZ Gene

This gene was present in the common ancestor of animals.

Orthologs for YWHAZ Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 34
  • 100 (a)
-- 34
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia YWHAZ 34
  • 100 (a)
(Pan troglodytes)
Mammalia YWHAZ 33
  • 99.86 (n)
(Bos Taurus)
Mammalia YWHAZ 33 34
  • 97.69 (n)
(Canis familiaris)
Mammalia YWHAZ 33 34
  • 97.69 (n)
(Mus musculus)
Mammalia Ywhaz 33 16 34
  • 92.93 (n)
(Rattus norvegicus)
Mammalia Ywhaz 33
  • 92.93 (n)
(Gallus gallus)
Aves YWHAZ 33 34
  • 91.56 (n)
(Anolis carolinensis)
Reptilia YWHAZ 34
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhaz 33
  • 82.45 (n)
MGC75570 33
(Danio rerio)
Actinopterygii ywhaz 34
  • 78 (a)
ywhabl 33
  • 73.33 (n)
wufb33b01 33
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zgr 35
  • 81 (a)
14-3-3zeta 33 34
  • 70.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007643 33
  • 67.62 (n)
(Caenorhabditis elegans)
Secernentea par-5 34
  • 76 (a)
ftt-2 33 34
  • 70.95 (n)
Species where no ortholog for YWHAZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAZ Gene

Gene Tree for YWHAZ (if available)
Gene Tree for YWHAZ (if available)

Paralogs for YWHAZ Gene

Variants for YWHAZ Gene

Sequence variations from dbSNP and Humsavar for YWHAZ Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000115841 -- 100,930,647(+) TTACT(C/T)TTTTC intron-variant
rs1000182180 -- 100,932,034(+) TGCCT(A/G)AATTC intron-variant
rs1000310937 -- 100,946,483(+) GAGGC(A/G)GAAGT intron-variant
rs1000317265 -- 100,947,839(+) ATTCC(A/C)AAAAC intron-variant
rs1000422586 -- 100,942,862(+) GTCCA(A/G)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YWHAZ Gene

Variant ID Type Subtype PubMed ID
nsv971342 CNV duplication 23825009
nsv971341 CNV duplication 23825009
nsv951460 CNV deletion 24416366
nsv831409 CNV loss 17160897
nsv508521 CNV deletion 20534489
nsv1077061 CNV deletion 25765185
esv3891451 CNV gain 25118596
esv3618198 CNV loss 21293372

Variation tolerance for YWHAZ Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YWHAZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAZ Gene

Disorders for YWHAZ Gene

Relevant External Links for YWHAZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for YWHAZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for YWHAZ Gene

Publications for YWHAZ Gene

  1. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Examination of association of genes in the serotonin system to autism. (PMID: 19184136) Anderson BM … Haines JL (Neurogenetics 2009) 3 45 60
  4. Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk. (PMID: 18290843) Mateo I … Combarros O (European journal of neurology 2008) 3 45 60
  5. 14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk. (PMID: 18319590) Mateo I … Combarros O (Dementia and geriatric cognitive disorders 2008) 3 45 60

Products for YWHAZ Gene

Sources for YWHAZ Gene