Aliases for YWHAZ Gene
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Delta Polypeptide 2 3
- Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide 2 3
- Protein Kinase C Inhibitor Protein 1 3 4
- 14-3-3 Delta 2 3
- 14-3-3 Zeta 2 3
- KCIP-1 3 4
- Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta Polypeptide 3
- 14-3-3 Protein/Cytosolic Phospholipase A2 3
External Ids for YWHAZ Gene
Previous HGNC Symbols for YWHAZ Gene
Previous GeneCards Identifiers for YWHAZ Gene
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for YWHAZ Gene
YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta) is a Protein Coding gene. Diseases associated with YWHAZ include gerstmann-straussler disease and akinetic mutism. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is YWHAE.
UniProtKB/Swiss-Prot for YWHAZ Gene
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.