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Aliases for YWHAZ Gene

Aliases for YWHAZ Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Delta Polypeptide 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide 2 3
  • Protein Kinase C Inhibitor Protein 1 3 4
  • 14-3-3 Delta 2 3
  • 14-3-3 Zeta 2 3
  • KCIP-1 3 4
  • Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta Polypeptide 3
  • 14-3-3 Protein/Cytosolic Phospholipase A2 3
  • Protein Kinase C Inhibitor Protein-1 3
  • Epididymis Secretory Protein Li 3 3
  • Epididymis Luminal Protein 4 3
  • 14-3-3 Protein Zeta/Delta 3
  • Phospholipase A2 3
  • 14-3-3-Zeta 3
  • HEL-S-3 3
  • YWHAD 3
  • HEL4 3

External Ids for YWHAZ Gene

Previous HGNC Symbols for YWHAZ Gene

  • YWHAD

Previous GeneCards Identifiers for YWHAZ Gene

  • GC08M100936
  • GC08M101999
  • GC08M101599
  • GC08M101887
  • GC08M102000
  • GC08M101930
  • GC08M097128

Summaries for YWHAZ Gene

Entrez Gene Summary for YWHAZ Gene

  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for YWHAZ Gene

YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is YWHAE.

UniProtKB/Swiss-Prot for YWHAZ Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Tocris Summary for YWHAZ Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules, apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon, sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand. Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the target that prevent molecular interactions and/or modulate the accessibility of a target protein to modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the 14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions, such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis. Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as cancer.

Gene Wiki entry for YWHAZ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAZ Gene

Genomics for YWHAZ Gene

Regulatory Elements for YWHAZ Gene

Transcription factor binding sites by QIAGEN in the YWHAZ gene promoter:

Genomic Location for YWHAZ Gene

Start:
100,916,525 bp from pter
End:
100,953,489 bp from pter
Size:
36,965 bases
Orientation:
Minus strand

Genomic View for YWHAZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for YWHAZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAZ Gene

Proteins for YWHAZ Gene

  • Protein details for YWHAZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63104-1433Z_HUMAN
    Recommended name:
    14-3-3 protein zeta/delta
    Protein Accession:
    P63104
    Secondary Accessions:
    • A8K1N0
    • B7Z465
    • P29213
    • P29312
    • Q32P43
    • Q5XJ08
    • Q6GPI2
    • Q6IN74
    • Q6NUR9
    • Q6P3U9
    • Q86V33

    Protein attributes for YWHAZ Gene

    Size:
    245 amino acids
    Molecular mass:
    27745 Da
    Quaternary structure:
    • Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2.
    SequenceCaution:
    • Sequence=AAH51814.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH73141.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YWHAZ Gene

    Alternative splice isoforms for YWHAZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for YWHAZ Gene

Proteomics data for YWHAZ Gene at MOPED

Post-translational modifications for YWHAZ Gene

  • The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.
  • Ubiquitination at Lys9, Lys11, Lys49, Lys115, Lys120, Lys122, Lys138, Lys139, Lys157, and Lys158
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for YWHAZ Gene

Domains for YWHAZ Gene

Protein Domains for YWHAZ Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P63104

UniProtKB/Swiss-Prot:

1433Z_HUMAN :
  • P63104
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAZ: view

No data available for Gene Families for YWHAZ Gene

Function for YWHAZ Gene

Molecular function for YWHAZ Gene

GENATLAS Biochemistry: tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3
UniProtKB/Swiss-Prot Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Gene Ontology (GO) - Molecular Function for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10026197
GO:0008134 transcription factor binding IPI 16114898
GO:0016301 kinase activity --
GO:0019901 protein kinase binding IPI 10102273
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with YWHAZ: view
genes like me logo Genes that share phenotypes with YWHAZ: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for YWHAZ Gene

Localization for YWHAZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAZ Gene

Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YWHAZ Gene COMPARTMENTS Subcellular localization image for YWHAZ gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with YWHAZ: view

Pathways for YWHAZ Gene

genes like me logo Genes that share pathways with YWHAZ: view

Gene Ontology (GO) - Biological Process for YWHAZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002553 histamine secretion by mast cell IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006605 protein targeting --
GO:0006626 protein targeting to mitochondrion IEA --
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with YWHAZ: view

Compounds for YWHAZ Gene

(2) Tocris Compounds for YWHAZ Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis [396834-58-5]
R18 Inhibitor of 14.3.3 proteins; induces apoptosis [211364-78-2]

(2) HMDB Compounds for YWHAZ Gene

Compound Synonyms Cas Number PubMed IDs
Sepiapterin
  • L-sepiapterin
17094-01-8
Zolpidem
  • Ambien
82626-48-0
genes like me logo Genes that share compounds with YWHAZ: view

Transcripts for YWHAZ Gene

Unigene Clusters for YWHAZ Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAZ Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2:
SP3: - - - - - - - -
SP4:
SP5:
SP6: -
SP7: -

Relevant External Links for YWHAZ Gene

GeneLoc Exon Structure for
YWHAZ
ECgene alternative splicing isoforms for
YWHAZ

Expression for YWHAZ Gene

mRNA expression in normal human tissues for YWHAZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for YWHAZ Gene

SOURCE GeneReport for Unigene cluster for YWHAZ Gene Hs.492407

genes like me logo Genes that share expressions with YWHAZ: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YWHAZ Gene

Orthologs for YWHAZ Gene

This gene was present in the common ancestor of animals.

Orthologs for YWHAZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YWHAZ 35
  • 99.86 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia YWHAZ 35
  • 97.69 (n)
  • 100 (a)
YWHAZ 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YWHAZ 35
  • 97.69 (n)
  • 100 (a)
YWHAZ 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ywhaz 35
  • 92.93 (n)
  • 99.59 (a)
Ywhaz 16
Ywhaz 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia YWHAZ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ywhaz 35
  • 92.93 (n)
  • 99.59 (a)
chicken
(Gallus gallus)
Aves YWHAZ 35
  • 91.56 (n)
  • 99.18 (a)
YWHAZ 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YWHAZ 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75570 35
ywhaz 35
  • 82.45 (n)
  • 90.61 (a)
zebrafish
(Danio rerio)
Actinopterygii wufb33b01 35
ywhabl 35
  • 73.33 (n)
  • 81.63 (a)
ywhaz 36
  • 78 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007643 35
  • 67.62 (n)
  • 78.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zeta 35
  • 70.75 (n)
  • 80.82 (a)
14-3-3zeta 36
  • 80 (a)
OneToMany
14-3-3zgr 37
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea ftt-2 35
  • 70.95 (n)
  • 81.74 (a)
ftt-2 36
  • 79 (a)
ManyToMany
par-5 36
  • 76 (a)
ManyToMany
Species with no ortholog for YWHAZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAZ Gene

ENSEMBL:
Gene Tree for YWHAZ (if available)
TreeFam:
Gene Tree for YWHAZ (if available)

Paralogs for YWHAZ Gene

Paralogs for YWHAZ Gene

genes like me logo Genes that share paralogs with YWHAZ: view

Variants for YWHAZ Gene

Sequence variations from dbSNP and Humsavar for YWHAZ Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs964917 -- 100,925,227(-) TTAAA(A/G)TATTG intron-variant
rs964919 -- 100,925,142(-) GTGTT(A/T)AAGTT intron-variant
rs983583 -- 100,949,682(-) CACTT(A/G)TAAAT intron-variant
rs1062376 -- 100,918,921(-) TGGGG(C/G)TAAGT utr-variant-3-prime
rs1062382 -- 100,918,901(-) AGCTC(A/C)CTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for YWHAZ Gene

Variant ID Type Subtype PubMed ID
nsv831409 CNV Loss 17160897
nsv508521 CNV Loss 20534489

Relevant External Links for YWHAZ Gene

HapMap Linkage Disequilibrium report
YWHAZ
Human Gene Mutation Database (HGMD)
YWHAZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAZ Gene

Disorders for YWHAZ Gene

Relevant External Links for YWHAZ

Genetic Association Database (GAD)
YWHAZ
Human Genome Epidemiology (HuGE) Navigator
YWHAZ
genes like me logo Genes that share disorders with YWHAZ: view

No data available for UniProtKB/Swiss-Prot for YWHAZ Gene

Publications for YWHAZ Gene

  1. 14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. (PMID: 7890696) Aitken A. … Patel Y. (J. Biol. Chem. 1995) 2 3
  2. Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. (PMID: 8617504) Tommerup N. … Leffers H. (Genomics 1996) 2 3
  3. Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis. (PMID: 1577711) Zupan L.A. … Gross R.W. (J. Biol. Chem. 1992) 3 4
  4. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PMID: 9360956) Dubois T. … Aitken A. (J. Biol. Chem. 1997) 3 4
  5. Two unique 5' untranslated regions in mRNAs encoding human 14-3-3 zeta: differential expression in hemopoietic cells. (PMID: 9512661) Seluja G.A. … Elias L. (Biochim. Biophys. Acta 1998) 3 4

Products for YWHAZ Gene

Sources for YWHAZ Gene

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