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YWHAZ Gene

protein-coding   GIFtS: 69
GCID: GC08M101930

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHAD)
  Search for YWHAZ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Zeta1 2
     14-3-3 Protein/Cytosolic Phospholipase A22
YWHAD1 2     14-3-3-zeta2
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Delta Polypeptide1 2
     HEL-S-32
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Zeta Polypeptide1 2
     HEL42
14-3-3 Delta1 2     Epididymis Luminal Protein 42
14-3-3 Zeta1 2     Epididymis Secretory Protein Li 32
Protein Kinase C Inhibitor Protein 12 3     Phospholipase A22
KCIP-12 3     Protein Kinase C Inhibitor Protein-12
14-3-3 Protein Zeta/Delta2     Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Zeta
Polypeptide2

External Ids:    HGNC: 128551   Entrez Gene: 75342   Ensembl: ENSG000001649247   OMIM: 6012885   UniProtKB: P631043   

Export aliases for YWHAZ gene to outside databases

Previous GC identifers: GC08M100936 GC08M101999 GC08M101599 GC08M101887 GC08M102000 GC08M097128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YWHAZ Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1
protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5'
UTR but that encode the same protein have been identified for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for YWHAZ Gene:
YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta) is a protein-coding gene. GO annotations related to this gene include transcription factor binding and identical protein binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

summary for YWHAZ Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAZ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAZ gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidYWHAZ promoter sequence
   Search Chromatin IP Primers for YWHAZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

YWHAZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAZ gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M101930:  view genomic region     (about GC identifiers)

Start:
101,928,753 bp from pter      End:
101,965,623 bp from pter
Size:
36,871 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104 (See protein sequence)
Recommended Name: 14-3-3 protein zeta/delta  
Size: 245 amino acids; 27745 Da
Subunit: Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1
(By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By
similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity).
Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58.
Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated
form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated
phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited
when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional
activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts
with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated
AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and
acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent
thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates
dimerization. Interacts with GAB2 and TLK2
Caution: Was originally (PubMed:1577711) thought to have phospholipase A2 activity
Sequence caution: Sequence=AAH51814.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH73141.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for YWHAZ (see all 14):
1IB1 (3D)        1QJA (3D)        1QJB (3D)        2C1J (3D)        2C1N (3D)        2O02 (3D)    
Secondary accessions: A8K1N0 B7Z465 P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9
Q86V33
Alternative splicing: 2 isoforms:  P63104-1   P63104-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for YWHAZ: NX_P63104

Explore proteomics data for YWHAZ at MOPED

Post-translational modifications: 

  • The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation
    on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on
    Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic
    subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and
    heterodimerization with YHAE and TP531
  • Ubiquitination2 at Lys9, Lys11, Lys49, Lys115, Lys120, Lys122, Lys138, Lys139, Lys157, Lys158
  • Modification sites at PhosphoSitePlus

  • See YWHAZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001129171.1  NP_001129172.1  NP_001129173.1  NP_001129174.1  NP_003397.1  NP_663723.1  

    ENSEMBL proteins: 
     ENSP00000379287   ENSP00000379286   ENSP00000309503   ENSP00000428860   ENSP00000430072  
     ENSP00000429623   ENSP00000428775   ENSP00000379283   ENSP00000379278   ENSP00000379281  
     ENSP00000395114   ENSP00000430058   ENSP00000429041   ENSP00000416551   ENSP00000394880  
     ENSP00000428381   ENSP00000430219   ENSP00000398599   ENSP00000379288  
    Reactome Protein details: P63104

    YWHAZ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for YWHAZ (14-3-3 zeta)
    Enzo Life Sciences proteins for YWHAZ
    OriGene Purified Proteins for YWHAZ
    OriGene Protein Over-expression Lysate for YWHAZ
    OriGene MassSpec for YWHAZ
    OriGene Custom Protein Services for YWHAZ
    GenScript Custom Purified and Recombinant Proteins Services for YWHAZ
    Novus Biologicals YWHAZ Proteins
    Novus Biologicals YWHAZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for YWHAZ
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for YWHAZ 

    YWHAZ Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAZ
    R&D Systems Antibodies for YWHAZ (14-3-3 zeta)
    Cell Signaling Technology (CST) Antibodies for YWHAZ  (14-3-3 zeta)
    OriGene Antibodies for YWHAZ
    OriGene Custom Antibody Services for YWHAZ
    Novus Biologicals YWHAZ Antibodies
    Abcam antibodies for YWHAZ (P63104, P31946)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for YWHAZ
    LSBio Antibodies in human, mouse, rat for YWHAZ

    YWHAZ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YWHAZ
    R&D Systems ELISAs for YWHAZ (14-3-3 zeta)
    GenScript Custom Assay Services for YWHAZ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for YWHAZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P63104

    ProtoNet protein and cluster: P63104

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433Z_HUMAN, P63104
    Similarity: Belongs to the 14-3-3 family


    Find genes that share domains with YWHAZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433Z_HUMAN, P63104
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner

         Genatlas biochemistry entry for YWHAZ:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10026197
    GO:0008134transcription factor binding IPI16114898
    GO:0016301kinase activity ----
    GO:0019901protein kinase binding IPI10102273
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with YWHAZ           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for YWHAZ:
     Decreased cell number and incr  Decreased viability of wild-ty  Decreased viability with pacli  G0/1 arrest 
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YWHAZ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YWHAZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAZ

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAZ:
    hsa-mir-877-3p (MIRT036887), hsa-let-7b-5p (MIRT052271), hsa-mir-155-5p (MIRT020711), hsa-mir-375 (MIRT019886), hsa-mir-193b-3p (MIRT006983), hsa-mir-30a-5p (MIRT028537), hsa-mir-378a-3p (MIRT043950), hsa-mir-423-5p (MIRT038013), hsa-mir-455-3p (MIRT037891), hsa-mir-340-3p (MIRT043854), hsa-mir-1229-3p (MIRT036384), hsa-mir-1 (MIRT023741), hsa-mir-484 (MIRT041843), hsa-mir-615-3p (MIRT039656)

    Block miRNA regulation of human, mouse, rat YWHAZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAZ (see all 121):
    hsa-miR-582-3p hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-1258 hsa-miR-938 hsa-miR-30d hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidYWHAZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YWHAZ
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YWHAZ

    Clone
    Products:
         
    OriGene clones in human, mouse for YWHAZ (see all 31)
    OriGene ORF clones in mouse, rat for YWHAZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): YWHAZ (NM_003406)
    Sino Biological Human cDNA Clone for YWHAZ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAZ

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for YWHAZ
    Browse ESI BIO Cell Lines and PureStem Progenitors for YWHAZ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1433Z_HUMAN, P63104: Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with YWHAZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YWHAZ About   (see all 59)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    3Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    4Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    5Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41


    Find genes that share SuperPaths with YWHAZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAZ
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAZ (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAZ
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAZ
        Insulin Pathway
    Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for YWHAZ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Development IGF-1 receptor signaling
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for YWHAZ (see all 22)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    IL-5 Signaling Pathway


    Selected Reactome Pathways for YWHAZ (see all 7)
        deactivation of the beta-catenin transactivating complex
    KSRP destabilizes mRNA
    Interleukin-3, 5 and GM-CSF signaling
    Activation of BAD and translocation to mitochondria
    GP1b-IX-V activation signalling


    Selected Kegg Pathways  (Kegg details for YWHAZ) (see all 8):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAZ: 
              Parkinson's Disease in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YWHAZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAZ (P631041, 2, 3 ENSP000003095034) via UniProtKB, MINT, STRING, and/or I2D (see all 1059)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628051, 2, 3, ENSP000003529804EBI-347088,EBI-302023 MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 STRING: ENSP00000352980
    HIST1H4LP628051, 2, 3, ENSP000003482584EBI-347088,EBI-302023 MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 STRING: ENSP00000348258
    HIST1H4BP628051, 2, 3EBI-347088,EBI-302023 MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    HIST1H4CP628051, 2, 3EBI-347088,EBI-302023 MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    HIST1H4DP628051, 2, 3EBI-347088,EBI-302023 MINT-7899812 MINT-7900157 MINT-3296655 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002553histamine secretion by mast cell IEA--
    GO:0006605protein targeting ----
    GO:0006626protein targeting to mitochondrion IEA--
    GO:0006915apoptotic process TAS--
    GO:0007165signal transduction TAS16130169

    Find genes that share ontologies with YWHAZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for YWHAZ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    2 HMDB Compounds for YWHAZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    SepiapterinL-sepiapterin (see all 8)17094-01-8--
    ZolpidemAmbien (see all 7)82626-48-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YWHAZ gene (6 alternative transcripts): 
    NM_001135699.1  NM_001135700.1  NM_001135701.1  NM_001135702.1  NM_003406.3  NM_145690.2  

    Unigene Cluster for YWHAZ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
    Hs.492407  [show with all ESTs]
    Unigene Representative Sequence: NM_145690
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000395957(uc011lhe.1 uc003yjv.2 uc011lhf.1 uc003yjx.2)
    ENST00000395956 ENST00000353245 ENST00000523848 ENST00000522542 ENST00000521309
    ENST00000522819 ENST00000395953 ENST00000395948 ENST00000395951 ENST00000419477
    ENST00000521607 ENST00000480304 ENST00000518736 ENST00000517727 ENST00000521328
    ENST00000418997 ENST00000437293
    miRNA
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    Block miRNA regulation of human, mouse, rat YWHAZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAZ (see all 121):
    hsa-miR-582-3p hsa-miR-193a-3p hsa-miR-188-5p hsa-miR-1258 hsa-miR-938 hsa-miR-30d hsa-miR-1244 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidYWHAZ 3' UTR sequence
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): YWHAZ (NM_003406)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAZ
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      QuantiTect SYBR Green Assays in human, mouse, rat YWHAZ
      QuantiFast Probe-based Assays in human, mouse, rat YWHAZ

    Additional mRNA sequence: 

    AK091235.1 AK289945.1 AK294647.1 AK296902.1 AK307506.1 AK315867.1 BC003623.2 BC013265.1 
    BC051814.1 BC063824.1 BC068456.1 BC070389.1 BC072426.1 BC073141.1 BC083508.1 BC099904.1 
    BC101483.1 BC108281.1 BC111951.1 DQ185048.1 M86400.1 S79449.1 U28964.1 

    Selected DOTS entries (see all 61):

    DT.91790906  DT.91831124  DT.92052153  DT.91790845  DT.97856507  DT.99944503  DT.100695674  DT.95296896 
    DT.100695689  DT.100695711  DT.91790795  DT.120929698  DT.100695700  DT.97864496  DT.100695703  DT.100695685 
    DT.91790909  DT.100695696  DT.121024130  DT.100695683  DT.95310558  DT.99947252  DT.86851675  DT.91753182 

    Selected AceView cDNA sequences (see all 1643):

    BQ962851 F11091 BU677311 AA227876 BQ675131 BQ889291 BU170982 BM829082 
    AA344422 CB054640 AA863052 BM451803 BC072426 CB148096 R51717 S79449 
    AA769956 BE875236 BM820488 BI259634 AV709595 BG289939 AA322000 T40149 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YWHAZ (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                  -     -                                       
    SP2:                                                                                                
    SP3:              -     -     -     -     -     -     -     -                                       
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for YWHAZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    YWHAZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGTGGAAT
    YWHAZ Expression
    About this image


    YWHAZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Mesoderm (Gastrulation Derivatives)
             Zone Of Polarizing Activity Cells Limb Bud
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    YWHAZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492407
        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAZ: 
              Parkinson's Disease in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAZ gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhaz1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 92.93(n)1
    99.59(a)1
      15 (14.56 cM)5
    226311  NM_001253805.11  NP_001240734.11 
     367707705 
    chicken
    (Gallus gallus)
    Aves YWHAZ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 91.56(n)
    99.18(a)
      425619  NM_001031343.1  NP_001026514.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAZ6
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...
    100(a)
    1 ↔ 1
    4(14559762-14593157)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041235.12   -- 84.51(n)    BC041235.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb33b012 wufb33b01 77.94(n)   321729  BC059441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3
    14-3-3zeta1
    RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more3
    14-3-3zeta1
    81(a)3
    70.75(n)1
    80.82(a)1
      360591  NM_206070.21  NP_995792.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-21 ftt-2 70.95(n)
    81.74(a)
      181348  NM_077538.4  NP_509939.1 
    rice
    (Oryza sativa)
    Liliopsida AK103145.12   -- 76.07(n)    AK103145.1 


    ENSEMBL Gene Tree for YWHAZ (if available)
    TreeFam Gene Tree for YWHAZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for YWHAZ gene
    YWHAH2  YWHAE2  YWHAB2  YWHAQ2  YWHAG2  SFN2  
    9 SIMAP similar genes for YWHAZ using alignment to 11 protein entries:     1433Z_HUMAN (see all proteins):
    14-3-3 protein    YWHAB    YWHAQ    YWHAH    SFN    YWHAG
    YWHAE/FAM22B fusion    YWHAE/FAM22A fusion    YWHAE

    Find genes that share paralogs with YWHAZ           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for YWHAZ (see all 11)
    PGOHUM00000256662 PGOHUM00000256681 PGOHUM00000256682 PGOHUM00000256739 PGOHUM00000247105


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YWHAZ (see all 738)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs712769281,2
    C--97152004(+) AAAAA-/CATCTCT 6 -- int11Minor allele frequency- CA:0.00NA 2
    rs1425584611,2
    C--101930389(+) AACATG/TGTGAA 6 -- ds50010--------
    rs1509471861,2
    C--101930463(+) CTACTC/TGGGAG 6 -- ds50010--------
    rs69839891,2
    C,F,A--101930496(+) aacccA/Cgcagg 6 -- ds50013Minor allele frequency- C:0.17NA WA 6
    rs1873792921,2
    --101930502(+) GCAGGC/TGGAGG 6 -- ds50010--------
    rs1921232541,2
    --101930575(+) TCCAAA/CAAAAA 6 -- ds50010--------
    rs1112460051,2
    C--101930587(+) AAAAAA/CAACAA 6 -- ds50010--------
    rs1808682041,2
    --101930671(+) ATATAA/TAATTA 6 -- ds50010--------
    rs574861631,2
    C--101930672(+) ATATA-/TATATATATATATA
    /TATATATATATATATA
    ATTAT
    6 -- ds50011NA 2
    rs1851764771,2
    --101930672(+) TATATA/GATTAT 6 -- ds50010--------

    HapMap Linkage Disequilibrium report for YWHAZ (101928753 - 101965623 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for YWHAZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831409CNV Loss17160897
    nsv508521CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAZ
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601288    OMIM disorders: --


    Find genes that share disorders with YWHAZ           About GenesLikeMe

    Genetic Association Database (GAD): YWHAZ
    Human Genome Epidemiology (HuGE) Navigator: YWHAZ (4 documents)

    Export disorders for YWHAZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for YWHAZ gene, integrated from 10 sources (see all 350):
    (articles sorted by number of sources associating them with YWHAZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Examination of association of genes in the serotonin system to autism. (PubMed id 19184136)1, 4 Anderson B.M....Haines J.L. (Neurogenetics 2009)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    4. Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk. (PubMed id 18290843)1, 4 Mateo I....Combarros O. (Eur. J. Neurol. 2008)
    5. 14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk. (PubMed id 18319590)1, 4 Mateo I....Combarros O. (Dement Geriatr Cogn Disord 2008)
    6. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    7. Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. (PubMed id 16376338)1, 2 Gu Y.-M.... Lee K.-Y. (FEBS Lett. 2006)
    8. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (Nat. Cell Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7534 HGNC: 12855 AceView: YWHAZ Ensembl:ENSG00000164924 euGenes: HUgn7534
    ECgene: YWHAZ Kegg: 7534 H-InvDB: YWHAZ

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YWHAZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for YWHAZ gene:
    Search GeneIP for patents involving YWHAZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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