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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAQ Gene

protein-coding   GIFtS: 70
GCID: GC02M009724

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Theta Polypeptide1 2
     14-3-3 Protein Theta2
14-3-3 Protein T-Cell2 3     1C52
14-3-3 Protein Tau2 3     HS12
Protein Tau1     Protein HS13
14-3-32     

External Ids:    HGNC: 128541   Entrez Gene: 109712   Ensembl: ENSG000001343087   OMIM: 6090095   UniProtKB: P273483   

Export aliases for YWHAQ gene to outside databases

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745 GC02M009674 GC02M009641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAQ Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with
amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic,
however, there is no correlation between the repeat number and the disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAQ Gene: 
YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide) is a protein-coding gene. Diseases associated with YWHAQ include lateral sclerosis, and amyotrophic lateral sclerosis, and among its related super-pathways are Cell cycle and Cell cycle Role of 14-3-3 proteins in cell cycle regulation. GO annotations related to this gene include protein N-terminus binding and protein domain specific binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAQ Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAQ gene promoter:
         GR   GR-beta   MyoD   NF-kappaB   CREB   deltaCREB   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAQ promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25.2-p25.1

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAQ gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009724:  view genomic region     (about GC identifiers)

Start:
9,724,101 bp from pter      End:
9,771,143 bp from pter
Size:
47,043 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348 (See protein sequence)
Recommended Name: 14-3-3 protein theta  
Size: 245 amino acids; 27764 Da
Subunit: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198'
phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with
the 'Ser-241' phosphorylated form of PDPK1
Subcellular location: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals
1 PDB 3D structure from and Proteopedia for YWHAQ:
2BTP (3D)    
Secondary accessions: D6W4Z5 Q567U5 Q5TZU8 Q9UP48

Explore the universe of human proteins at neXtProt for YWHAQ: NX_P27348

Explore proteomics data for YWHAQ at MOPED 

Post-translational modifications:

  • UniProtKB: Ser-232 is probably phosphorylated by CK1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27348

  • YWHAQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YWHAQ Protein Expression
    REFSEQ proteins: NP_006817.1  
    ENSEMBL proteins: 
     ENSP00000371267   ENSP00000238081   ENSP00000398990  
    Reactome Protein details: P27348
    Human Recombinant Protein Products for YWHAQ: 
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    Sino Biological Recombinant Protein for YWHAQ
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    ProSpec Recombinant Protein for YWHAQ
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15163635
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane TAS--
    GO:0043234protein complex ----
    GO:0070062extracellular vesicular exosome IDA--

    YWHAQ for ontologies           About GeneDecksing



    YWHAQ Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAQ
    R&D Systems Antibodies for YWHAQ (14-3-3 theta)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry P27348

    ProtoNet protein and cluster: P27348

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Similarity: Belongs to the 14-3-3 family


    YWHAQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433T_HUMAN, P27348
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAQ:
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide stratifin,with likely
    several forms,one expressed in the cytoplasmic of keratinocyte,another in T cells,multifunctional regulator
    involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10954706
    GO:0019904protein domain specific binding IEA--
    GO:0047485protein N-terminus binding IPI11984006
    GO:007188914-3-3 protein binding ----
         
    YWHAQ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YWHAQ:
     Decreased telomerase activity 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ywhaq):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  muscle 

    YWHAQ for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YWHAQ 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAQ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAQ 

    miRNA
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    miRTarBase miRNAs that target YWHAQ:
    hsa-mir-1 (MIRT001321)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAQ
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAQ (see all 45):
    hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidYWHAQ 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for YWHAQ About   (see all 50)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Slit-Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for YWHAQ
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAQ
        Apoptosis Signaling Pathways

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAQ (see all 19)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    4 Cell Signaling Technology (CST) Pathways for YWHAQ
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAQ
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAQ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/19 BioSystems Pathways for YWHAQ (see all 19)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    Alpha6-Beta4 Integrin Signaling Pathway


    5/6        Reactome Pathways for YWHAQ (see all 6)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    5/8         Kegg Pathways  (Kegg details for YWHAQ) (see all 8):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Pathogenic Escherichia coli infection


    YWHAQ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/628 Interacting proteins for YWHAQ (P273481, 2, 3 ENSP000002380814) via UniProtKB, MINT, STRING, and/or I2D (see all 628)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628052, 3, ENSP000003581624MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA15163635
    GO:0097193intrinsic apoptotic signaling pathway TAS--

    YWHAQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    Search CenterWatch for drugs/clinical trials and news about YWHAQ / 1433T

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YWHAQ gene: 
    NM_006826.3  

    Unigene Cluster for YWHAQ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
    Hs.74405  [show with all ESTs]
    Unigene Representative Sequence: NM_006826
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381844 ENST00000238081(uc002qzx.3) ENST00000474715 ENST00000446619
    ENST00000460093

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    Additional mRNA sequence: 

    AF070556.1 AK297624.1 AK302208.1 AK309462.1 AK316158.1 BC050601.1 BC056867.1 BC093019.1 
    BT020014.1 X56468.1 X57347.1 

    24/46 DOTS entries (see all 46):

    DT.91782977  DT.91898346  DT.100843216  DT.91782983  DT.91728702  DT.95249123  DT.120640215  DT.100884295 
    DT.95249166  DT.91901902  DT.100884298  DT.86852191  DT.100884268  DT.121011162  DT.100884272  DT.100884302 
    DT.121011197  DT.121224056  DT.97770024  DT.100804899  DT.100884293  DT.102839040  DT.120640233  DT.91714850 

    24/1318 AceView cDNA sequences (see all 1318):

    BF792240 BU149866 BM475163 BC050601 BI858795 BU567612 CR615240 BG780029 
    BM451828 AI061383 BG498584 BM788198 CB121110 BM980715 F02134 BI871518 
    CB123841 BQ019939 AA084637 BQ955126 BQ347549 BQ925373 AA187516 BE909106 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                          -           -                                             
    SP2:                          -           -     -                                       
    SP3:                          -           -     -     -     -                           
    SP4:                          -                                                         
    SP5:                                      -                                             


    ECgene alternative splicing isoforms for YWHAQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAQ expression in normal human tissues (normalized intensities)      YWHAQ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCATCTCT
    YWHAQ Expression
    About this image


    YWHAQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Kidney (Urinary System)
             visceral organ/mesonephros/mesonephric mesenchyme   

    See YWHAQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAQ

    SOURCE GeneReport for Unigene cluster: Hs.74405

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta.
    Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared
    with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement

        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAQ: 
              mTOR Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YWHAQ
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAQ
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAQ
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAQ
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAQ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAQ gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhaq1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.74(n)1
    99.59(a)1
      12 (8.31 cM)5
    226301  NM_011739.31  NP_035869.11 
     213900715 
    chicken
    (Gallus gallus)
    Aves YWHAQ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 88.03(n)
    98.78(a)
      421932  NM_001006415.1  NP_001006415.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAQ6
    Uncharacterized protein
    96(a)
    1 ↔ 1
    1(148381388-148402159)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044989.12   -- 78.78(n)    BC044989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.10682 Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more 83.4(n)    BC044412.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more
    77(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-26
    par-56
    14-3-3-like protein 1
    75(a)
    73(a)
    many ↔ many
    many ↔ many
    X(11603707-11605421)
    IV(11820505-11821924)
    rice
    (Oryza sativa)
    Liliopsida Os.26732 Rice mRNA for brain specific protein (S94 gene), complete more 77.55(n)    AK062077.1 


    ENSEMBL Gene Tree for YWHAQ (if available)
    TreeFam Gene Tree for YWHAQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAQ gene
    YWHAH2  YWHAE2  YWHAB2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAQ using alignment to 4 protein entries:     1433T_HUMAN (see all proteins):
    14-3-3 protein    YWHAB    YWHAZ    SFN    YWHAH    YWHAG
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAQ for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for YWHAQ (see all 9)
    PGOHUM00000239811 PGOHUM00000239865 PGOHUM00000247782 PGOHUM00000244499 PGOHUM00000240813


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    827/1044 SNPs in YWHAQ are shown (see all 1044)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409278291,2
    --9723606(+) AATAAC/TAGCTA 1 -- ds50010--------
    rs1432994861,2
    C--9723616(+) ATTGTG/TATACT 1 -- ds50010--------
    rs116921121,2
    C,F,H--9723732(+) TGACAG/TGCATT 1 -- ds50017Minor allele frequency- T:0.17NA CSA WA 248
    rs1903986971,2
    --9723803(+) AAATTA/GCCTGA 1 -- ds50010--------
    rs1511918181,2
    C--9723813(+) AGAGAG/TCCAAC 1 -- ds50010--------
    rs789296741,2
    C,F--9723818(+) TCCAAC/TGCTTT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1403417241,2
    C--9723854(+) TGATTG/TTGCCC 1 -- ds50010--------
    rs1826118531,2
    C--9723972(+) TGCAAA/TGGGTT 1 -- ds50010--------
    rs75941,2
    C,F,H--9724267(-) ATTGTG/ACATTG 1 -- ut31 ese37Minor allele frequency- A:0.13NS WA NA 904
    rs1876803371,2
    --9724272(+) CACAAC/TGTGGA 1 -- ut310--------
    rs67582141,2
    C--9724476(+) GGGACA/TACAGT 1 -- ut31 ese30--------
    rs1911073031,2
    --9724542(+) AAACTA/GGACAC 1 -- ut310--------
    rs1477018761,2
    C--9724611(+) TGTAC-/TTTAA 
            
    TTTAT
    1 -- ut310--------
    rs601525221,2
    --9724615(+) CTTTA-/ATTTA 
            
    TTTCC
    1 -- ut310--------
    rs1824448651,2
    --9724664(+) AATTTA/GCCAAA 1 -- ut310--------
    rs1891044001,2
    --9724750(+) GAGGTG/TTAAGT 1 -- ut310--------
    rs115444591,2
    C,H--9724767(-) CCTCCC/AAATAA 1 -- ut31 trp32Minor allele frequency- A:0.01NS NA 182
    rs1923183591,2
    --9724844(+) CACAAC/GACCTC 1 -- ut310--------
    rs1845096441,2
    --9724850(+) ACCTCC/TGTATG 1 -- ut310--------
    rs1873408491,2
    --9725123(+) ATTACA/TTAAAT 1 -- ut310--------
    rs168224361,2
    F--9725323(-) AGAAAC/TCCATT 1 -- ut311Minor allele frequency- T:0.06MN 184
    rs412641771,2
    C--9725395(+) AAGAAA/GGATGA 1 -- ut310--------
    rs1450978911,2
    C--9725396(+) AGAAGA/GATGAC 1 -- ut310--------
    rs1918307071,2
    C--9725397(+) GAAGGA/GTGACA 1 -- ut310--------
    rs1997376721,2
    --9725415(+) TGGATC/TTAGTT 2 * syn10--------
    rs1848062721,2
    C--9725485(+) AAAAGA/CAGAAT 1 -- int10--------
    rs1128343881,2
    C--9725559(+) ACTACAA/-GAGTA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1894612431,2
    --9725760(+) GGCCAA/GGCACA 1 -- int10--------
    rs1423227171,2
    --9725775(+) CTCACA/GCCTGT 1 -- int10--------
    rs67154081,2
    C,F--9725817(+) AGATCG/ACATGA 1 -- int19Minor allele frequency- A:0.12NA WA CSA EA 370
    rs1464022211,2
    C--9725864(+) TCCCAC/TGTCTA 1 -- int10--------
    rs64320201,2
    C,F,A,H--9725920(+) GCCTAT/CAGTCC 1 -- int113Minor allele frequency- C:0.45NA WA CSA EA 379
    rs1391100791,2
    --9725943(+) AGGCTA/GAGGCA 1 -- int10--------
    rs64320211,2
    C,H--9726037(+) ATCCTG/TTCTCA 1 -- int17Minor allele frequency- T:0.00NA WA CSA 13
    rs1809392691,2
    --9726105(+) CAAAGA/TGATAG 1 -- int10--------
    rs1841225431,2
    --9726207(+) AAAGCC/TACAAT 1 -- int10--------
    rs1430838691,2
    C--9726269(+) ACTTAA/CTTTGT 1 -- int10--------
    rs67058401,2
    C,F--9726538(+) TATGAA/CGATAC 1 -- int12Minor allele frequency- C:0.24WA 120
    rs747923201,2
    F--9726564(+) AAAACA/GAAATC 1 -- int11Minor allele frequency- G:0.05WA 118
    rs621194221,2
    C,F--9726599(+) GAGATA/GACAAA 1 -- int13Minor allele frequency- G:0.15NA WA 240
    rs621194231,2
    C,F--9726601(+) GATAAC/TAAAAC 1 -- int13Minor allele frequency- T:0.15NA WA 240
    rs1896324001,2
    --9726642(+) GTATAC/TATCTG 1 -- int10--------
    rs763388771,2
    C,F--9726676(+) TGCTCT/CTCCTC 1 -- int11Minor allele frequency- C:0.02NA 120
    rs751726061,2
    F--9726773(+) CTTTCA/CGTGGA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs116845681,2
    C,F,H--9726896(+) ATTAAA/GAGATT 1 -- int15Minor allele frequency- G:0.04NS EA WA 536
    rs1437267801,2
    --9726928(+) GTGAAA/GTCTAA 1 -- int10--------
    rs168670631,2
    C,F,H--9727023(+) ATCAAT/CTGCCT 1 -- int118Minor allele frequency- C:0.05NA NS EA WA 2044
    rs116897411,2
    C,F,A,H--9727038(+) AAGAAG/ACAGGG 1 -- int15Minor allele frequency- A:0.02NS EA WA 536
    rs1481371611,2
    --9727092(+) AAGGAA/GTAAGT 1 -- int10--------
    rs1818959151,2
    C--9727178(+) GGTACC/TTCCTG 1 -- int10--------
    rs1862189741,2
    --9727210(+) ATTTAC/GATAGT 1 -- int10--------
    rs1905435311,2
    --9727427(+) TAACAC/TGTATC 1 -- int10--------
    rs1815316811,2
    --9727502(+) TTTTGA/TTTCTG 1 -- int10--------
    rs413081841,2
    C,F--9727657(+) ATATCC/TATGGT 1 -- int19Minor allele frequency- T:0.11NA WA CSA EA 370
    rs1866116571,2
    C--9727667(+) TAAAAC/TATGTG 1 -- int10--------
    rs798713331,2
    C--9727672(+) TATGTA/GCATTG 1 -- int10--------
    rs2014502141,2
    --9727687(+) AAACTA/GGTTAT 1 -- int10--------
    rs763823191,2
    C--9727760(+) AAACTA/CAACAG 1 -- int10--------
    rs1419702671,2
    --9727836(+) ACTTAA/GTAAAC 1 -- int10--------
    rs1910278661,2
    --9727847(+) AAGCAA/TGTCTT 1 -- int10--------
    rs1828776441,2
    C--9728001(+) ACCAAA/GCCTGG 1 -- int10--------
    rs1875911821,2
    C--9728277(+) ATTTCC/TTGGAC 1 -- int10--------
    rs2008847451,2
    --9728380(+) GCGGAC/TTGGGT 2 I V mis10--------
    rs1995159281,2
    --9728404(+) CTCTTC/TCTTGC 2 K E mis10--------
    rs2014871771,2
    --9728405(+) TCTTTC/TTTGCT 2 K syn10--------
    rs2012654591,2
    C--9728468(+) AAGAGC/TGAAAA 1 -- int10--------
    rs762788721,2
    C,F--9728469(+) AGAGCG/AAAAAA 1 -- int11Minor allele frequency- A:0.08WA 118
    rs677242561,2
    C,F--9728574(+) TCTGTA/GTGGGT 1 -- int13Minor allele frequency- G:0.25NA 124
    rs727770351,2
    C,F--9728577(+) GTATGG/TGTCTT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1910570621,2
    --9728849(+) GAGCCA/GACATC 1 -- int10--------
    rs1831856261,2
    --9728860(+) ACACCA/GCTGCA 1 -- int10--------
    rs75656461,2
    C,F,A,H--9728879(+) tgggcG/Aacaga 1 -- int19Minor allele frequency- A:0.34NA WA CSA 139
    rs1874782911,2
    --9728881(+) GGCAAC/GAGAAC 1 -- int10--------
    rs1506804931,2
    --9728912(+) AACAAA/GCAAAA 1 -- int10--------
    rs1401861951,2
    C--9728941(+) TATTTA/GAGAAC 1 -- int10--------
    rs1921883451,2
    --9728949(+) AACTTC/GTTTAT 1 -- int10--------
    rs1850085601,2
    --9729000(+) GGGAAA/GGTGAG 1 -- int10--------
    rs1882746281,2
    --9729099(+) AATAAA/TAAATA 1 -- int10--------
    rs1926932731,2
    --9729121(+) TAGTGC/TGTGCC 1 -- int10--------
    rs1423157961,2
    --9729124(+) TGCGTA/GCCTGT 1 -- int10--------
    rs1846410701,2
    --9729153(+) GGCTGA/GGGTGG 1 -- int10--------
    rs130241421,2
    C,F--9729165(+) aggacC/Tccttg 1 -- int13Minor allele frequency- T:0.24NA 124
    rs760397121,2
    C,F--9729177(+) GCCCAG/TGAGGT 1 -- int12Minor allele frequency- T:0.05WA 120
    rs1459331391,2
    --9729367(+) CTATTG/TTCTTA 1 -- int10--------
    rs1398315321,2
    --9729389(+) TTAATA/TCTATT 1 -- int10--------
    rs1882164081,2
    --9729390(+) TAATTA/CTATTA 1 -- int10--------
    rs1496904731,2
    --9729542(+) ACCCCA/GTCTCT 1 -- int10--------
    rs1136420671,2
    C,F--9729607(+) ACTTGG/AGAGGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1484436201,2
    --9729636(+) GAACCC/TGGGAG 1 -- int10--------
    rs1129575991,2
    C,F--9729653(+) CTTACG/AGTGAG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs134151361,2
    C,F,A--9729708(+) ACTCCG/ATTCAA 1 -- int110Minor allele frequency- A:0.22NA WA CSA 252
    rs1481981901,2
    C--9729716(+) AAAAT-/TAATAATA 1 -- cds10--------
    rs1510017061,2
    --9729765(+) ATAATA/GTAAAC 1 -- int10--------
    rs37917481,2
    C,F,A,H--9729815(+) ATTTGC/GAGAAA 1 -- int120Minor allele frequency- G:0.23EA NA NS WA CSA 2616
    rs1422990721,2
    --9729902(+) GACCAC/GAGTTT 1 -- int10--------
    rs1462087171,2
    C--9729919(+) TAGCCC/TAATTA 1 -- int10--------
    rs134207461,2
    C,F,H--9729971(+) ACTAAT/CCTGAT 1 -- int110Minor allele frequency- C:0.03NS EA WA NA 1212
    rs1163087891,2
    F--9730049(+) CTGACG/ATAAGA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1478718991,2
    --9730137(+) CTGACC/TGGTAC 1 -- int10--------
    rs173627341,2
    C,F,H--9730208(+) CAATTA/GGGCTA 1 -- int113Minor allele frequency- G:0.10NA NS EA WA 922
    rs1820012391,2
    --9730214(+) GGCTAC/TAAAGA 1 -- int10--------
    rs1141592851,2
    C,F--9730335(+) CTCAAT/CCTCCC 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1415846701,2
    --9730788(+) TTTATC/TATCAA 1 -- int10--------
    rs119000611,2
    H--9730795(+) TCAAGT/GTAGGC 1 -- int14Minor allele frequency- G:0.00NS EA 414
    rs1849871041,2
    --9730835(+) TTTCTA/GTGATA 1 -- int10--------
    rs1893209811,2
    --9730899(+) TACTTA/GATTAA 1 -- int10--------
    rs168670641,2
    C,F,H--9731036(+) TGATTA/GTATGT 1 -- int18Minor allele frequency- G:0.03NA NS EA WA 658
    rs1820232121,2
    --9731124(+) TCCACA/GTTCTG 1 -- int10--------
    rs1504279891,2
    C--9731169(+) TAATAC/GAAAGG 1 -- int10--------
    rs1865612181,2
    --9731178(+) GGCCAG/TGTGAA 1 -- int10--------
    rs1382187981,2
    --9731185(+) TGAAAC/TGCAGA 1 -- int10--------
    rs1379677391,2
    C--9731243(+) GAACC-/AAAATTC 1 -- int10--------
    rs1900376581,2
    --9731246(+) CCAAAA/TTTCTA 1 -- int10--------
    rs800540181,2
    F--9731257(+) AAAAGC/TATAAA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1812509481,2
    --9731360(+) TCCAAA/TTTTCA 1 -- int10--------
    rs1496038941,2
    --9731370(+) ATTTTA/TGAGAA 1 -- int10--------
    rs573400891,2
    C,F--9731495(+) CTACTT/CTTGCC 1 -- int13Minor allele frequency- C:0.21WA CSA 124
    rs1852118531,2
    C--9731611(+) ATTAGC/TTGCAT 2 T A mis10--------
    rs1433502621,2
    --9731727(+) CTAGCA/GGGCAT 1 -- int10--------
    rs1389777241,2
    C--9731775(+) CAGCCG/TGGACT 1 -- int10--------
    rs1896339731,2
    --9731876(+) GGCTAA/GATTCT 1 -- int10--------
    rs739131401,2
    C,F--9731889(+) ATTACA/TCCAAA 1 -- int12Minor allele frequency- T:0.12WA 120
    rs1821116931,2
    --9732058(+) TAAGAA/GAGATG 1 -- int10--------
    rs1422304541,2
    --9732071(+) AATACA/GGTGCT 1 -- int10--------
    rs1464054721,2
    --9732091(+) CACAGA/CTGGAG 1 -- int10--------
    rs1167047631,2
    C,F--9732257(+) AGGGAG/CAATAG 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1144449491,2
    C,F--9732279(+) GCCCTT/CTGCAT 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1863328611,2
    --9732324(+) ATCGAC/GAGTAA 1 -- int10--------
    rs1398121261,2
    --9732424(+) TTTTGC/TCCCTA 1 -- int10--------
    rs1917969261,2
    --9732448(+) AAATTC/TTCACT 1 -- int10--------
    rs1485396931,2
    C--9732517(+) AGAAA-/TCTTCTTA 1 -- int10--------
    rs1838467741,2
    C--9732626(+) AAGGCA/GGGCAG 1 -- int10--------
    rs1411528901,2
    C--9732665(+) CTGGCC/TAACAT 1 -- int10--------
    rs1883356641,2
    C--9732762(+) GGCAGA/GAGAAT 1 -- int10--------
    rs1929792071,2
    --9732916(+) GAAATC/TCTCAT 1 -- int10--------
    rs168670651,2
    C,F,H--9733013(+) CATGTT/GAAGTA 1 -- int117Minor allele frequency- G:0.02NA NS EA WA 1674
    rs1828762041,2
    --9733048(+) GCCTAA/GGTACA 1 -- int10--------
    rs1870584041,2
    C--9733132(+) TTTACA/GTTTTG 1 -- int10--------
    rs1914776651,2
    --9733207(+) CAAGTA/CTGGAG 1 -- int10--------
    rs1836236081,2
    --9733283(+) TTAAAA/GATATA 1 -- int10--------
    rs1894888651,2
    --9733360(+) GCATCC/GATGTC 1 -- int10--------
    rs341270511,2
    C--9733384(+) TTTTT-/T/TT  
            
    TTGAG
    1 -- int11NA 2
    rs1119676451,2
    C,F--9733577(+) AAGTGG/ATCTGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1122100081,2
    C--9733731(+) CAAGAGGATT/
            
    GCCTG
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1854601641,2
    --9733918(+) TGCCAC/TTGCAT 1 -- int10--------
    rs1899346251,2
    --9733953(+) GAGATC/GCTGTC 1 -- int10--------
    rs3718869511,2
    --9734026(+) TAGAT-/TATAAAA 1 -- int10--------
    rs1510475301,2
    C--9734027(+) AGATT-/A/    
       AAAAA
    AAAAA
    1 -- int10--------
    rs580025951,2
    C--9734028(+) GATTA-/AAAA/T
            
    AAAAA
    1 -- int10--------
    rs2001150131,2
    --9734036(+) AAAAA-/TATATA 1 -- int10--------
    rs1485032271,2
    C--9734050(+) TATAT-/ACAC  
            
    ATACA
    1 -- int10--------
    rs602412751,2
    C--9734053(+) ATATA-/AC    
       
    /TACA
    CACAC
    1 -- int10--------
    rs348721371,2
    C--9734106(+) CACAC-/ACGCACG 1 -- int10--------
    rs594030851,2
    C--9734129(+) CACAC-/AC/CG 
            
    GCACG
    1 -- int10--------
    rs739131411,2
    C,F--9734130(+) CACACG/ACACGC 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs787530551,2
    F--9734143(+) AAAAAA/TTTAGT 1 -- int11Minor allele frequency- T:0.06WA 118
    rs776079961,2
    C--9734156(+) AAAATG/TATGTA 1 -- int10--------
    rs1815158531,2
    --9734169(+) GAAGTC/TTCAGA 1 -- int10--------
    rs1855590741,2
    --9734175(+) TCAGAA/GGTTTA 1 -- int10--------
    rs116747691,2
    C,F,A,H--9734278(+) CCAAAT/CTAAAG 1 -- int114Minor allele frequency- C:0.50NS EA NA WA CSA 913
    rs1884161281,2
    --9734326(+) CTTAAC/TTGTAA 1 -- int10--------
    rs116747771,2
    C,F,A,H--9734350(+) ATCAGT/ATTTTC 1 -- int121Minor allele frequency- A:0.46NA NS EA WA CSA 1278
    rs75678111,2
    C,F,H--9734502(+) AAACTA/GTTTTT 1 -- int14Minor allele frequency- G:0.01NS EA 418
    rs1499244161,2
    --9734548(+) GGTAGA/GAGGCA 1 -- int10--------
    rs1476083901,2
    --9734584(+) TCTAGA/TTCTCA 1 -- int10--------
    rs1405398331,2
    --9734636(+) AGAAGC/TAGTAT 1 -- int10--------
    rs1445043961,2
    --9734735(+) CTCTCA/CCTTTT 1 -- int10--------
    rs1808484001,2
    --9734781(+) AATTCC/TACAGG 1 -- int10--------
    rs104955721,2
    C,F,H--9734859(-) TAGGTG/CTTAAA 1 -- int1103Minor allele frequency- C:0.39NS NA EA PA EU CA WA 6448
    rs1146862261,2
    C,F--9734891(+) ATTTGT/CAAGAG 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1850618471,2
    --9734921(+) GACTAA/GAACAA 1 -- int10--------
    rs1164587251,2
    C,F--9734937(+) TAGGGT/CGAGGA 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1924698831,2
    --9735224(+) TTCAGC/TCAGGT 1 -- int10--------
    rs798876991,2
    C--9735228(+) GCCAGC/GTATCA 1 -- int10--------
    rs1490624961,2
    C--9735230(+) CAGGT-/ATCATGGT 1 -- int10--------
    rs1870734001,2
    --9735368(+) CTTCAC/TGTCTT 1 -- int10--------
    rs1163019601,2
    C,F--9735548(+) AGGAGC/TGAGGG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1916630991,2
    --9735626(+) GTCAGC/GAGTTC 1 -- int10--------
    rs67062271,2
    C,A,H--9735651(+) CACCAT/CGGTGA 1 -- int14Minor allele frequency- C:0.14NA WA CSA 7
    rs1414940211,2
    --9735681(+) ATACAA/CAATTA 1 -- int10--------
    rs1155345671,2
    F--9735777(+) CCAGTG/AAGCTG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1428052661,2
    --9735789(+) GATATG/TGCACT 1 -- int10--------
    rs349020071,2
    C--9735828(+) AAAAA-/AGTCAC 1 -- int12Minor allele frequency- A:0.25NA 4
    rs67344691,2
    C,F,A,H--9735900(+) TGTACG/ATTATT 1 -- int195Minor allele frequency- A:0.26NS EA PA EU CA WA NA CSA 4660
    rs1510538941,2
    C--9735941(+) AAACTC/GGTTAG 1 -- int10--------
    rs1829034471,2
    --9735967(+) TGGGAA/GTTTTG 1 -- int10--------
    rs104955711,2
    C,F,H--9736066(-) TAGTTT/CTCAAA 1 -- int1104Minor allele frequency- C:0.06NS NA EA PA EU CA WA 6454
    rs1152745751,2
    C,F--9736243(+) AACAAT/CAGACT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1410022601,2
    --9736288(+) TGAAAC/GTGTTG 1 -- int10--------
    rs1502283051,2
    --9736552(+) TTTTAC/GAGAGT 1 -- int10--------
    rs1389586641,2
    --9736618(+) TACACA/GCAAAA 1 -- int10--------
    rs1133585181,2
    F--9736640(+) AAAAAC/AATGTT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1458528181,2
    --9736686(+) TTCATC/TAGCAA 1 -- int10--------
    rs791092971,2
    F--9736739(+) TATCAG/TTCATT 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1384858241,2
    --9736780(+) AATAGA/CCCCTA 1 -- int10--------
    rs1492365801,2
    C--9736812(+) GATAAA/GGCCAA 1 -- int10--------
    rs354258691,2
    C,F--9736831(+) TTTTTT/-CCCCC 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs64320231,2
    C,F,A,H--9736874(+) CAACCT/CAGACT 1 -- int117Minor allele frequency- C:0.49NS EA NA WA CSA 785
    rs774797101,2
    C--9736923(+) CGCCTC/GCCGGT 1 -- int10--------
    rs1160571611,2
    F--9736959(+) CCCCAA/GGTAAC 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1444552151,2
    --9737021(+) CGCCCC/TCTTCA 1 -- int10--------
    rs739131421,2
    C,F--9737058(+) CCTGAG/CCCACG 1 -- int12Minor allele frequency- C:0.05WA 120
    rs739131431,2
    C,F--9737167(+) TTGTGG/CAACTT 1 -- int12Minor allele frequency- C:0.05WA 120
    rs1479895611,2
    --9737174(+) ACTTTC/TATACT 1 -- int10--------
    rs130243601,2
    C,F,H--9737184(+) TATCGT/CTAGCT 1 -- int122Minor allele frequency- C:0.12NS EA NA WA 2326
    rs168670661,2
    C,F,H--9737281(+) CTCAGA/CAACTA 1 -- int18Minor allele frequency- C:0.01NA NS EA WA 558
    rs1871983491,2
    --9737418(+) ATTTTC/TGATCA 1 -- int10--------
    rs119024311,2
    C,F,A,H--9737547(+) cggggA/Tgggcg 1 -- int14Minor allele frequency- T:0.38NA WA CSA 8
    rs1405014991,2
    --9737561(+) CACGAC/GGTCAG 1 -- int10--------
    rs621194251,2
    C,F--9737988(+) ATCTCG/ACCCAG 1 -- int14Minor allele frequency- A:0.16WA NA CSA 126
    rs1112436591,2
    C,F--9738008(+) CAATGG/ACATGA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1916320961,2
    C--9738012(+) GGCATC/GATCTC 1 -- int10--------
    rs782428941,2
    C,F--9738107(+) CCATGG/CCGGGC 1 -- int11Minor allele frequency- C:0.00WA 2
    rs1867685061,2
    --9738109(+) ATGCCG/TGGCTA 1 -- int10--------
    rs1932899821,2
    --9738149(+) GTAGAC/GACAAG 1 -- int10--------
    rs1122198751,2
    F--9738206(+) GGTCCG/ACCTGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs777649271,2
    C,F--9738360(+) GCCTAA/CTCAGA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1451816551,2
    --9738492(+) TGGCTG/TCCCAG 1 -- int10--------
    rs1854718601,2
    --9738643(+) TGTCTA/GTCAGA 1 -- int10--------
    rs75694851,2
    C,F,A,H--9738774(+) attaaT/Cgttac 1 -- int122Minor allele frequency- C:0.47NS EA NA WA CSA 2338
    rs116953341,2
    C,F,H--9738793(+) ttgttT/Ctgggg 1 -- int11Minor allele frequency- C:0.13WA 118
    rs621194261,2
    F--9738884(+) GCTCCC/TAATCT 1 -- int12Minor allele frequency- T:0.06NA 122
    rs1491490411,2
    C--9738899(+) TGTCTC/TCTCTG 1 -- int10--------
    rs1436912651,2
    --9738965(+) ACAATA/GGCCTT 1 -- int10--------
    rs1468164381,2
    --9739051(+) GGAAGA/GCATGT 1 -- int10--------
    rs1406417051,2
    --9739054(+) AGGCAG/TGTCGA 1 -- int10--------
    rs768144291,2
    F--9739065(+) AAGCCA/CAGACA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1146568491,2
    F--9739108(+) ATGTCG/ATAAGT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1905229921,2
    --9739147(+) AAAGTC/GCTACC 1 -- int10--------
    rs102102251,2
    C,F--9739225(+) gtctgG/Aataga 1 -- int112Minor allele frequency- A:0.44NA WA CSA EA 373
    rs593148001,2
    C--9739227(+) CTGAAC/TAGAAG 1 -- int10--------
    rs1384616571,2
    C--9739379(+) TGACCA/GAAAGA 1 -- int10--------
    rs118878631,2
    C,F,A,H--9739429(+) agtgcT/Gaatgt 1 -- int111Minor allele frequency- G:0.45NA WA CSA EA 372
    rs1929370231,2
    --9739506(+) ATACCA/GTATTT 1 -- int10--------
    rs1410847561,2
    --9739520(+) ATGTAA/GAGGAA 1 -- int10--------
    rs1842032501,2
    --9739548(+) GATGCC/TATCAA 1 -- int10--------
    rs11119761,2
    C,F,A,H--9739555(-) aaagtC/Acttga 1 -- int123Minor allele frequency- A:0.46NS EA NA WA CSA 2348
    rs1502808181,2
    --9739612(+) GCTAAC/TTGCAG 1 -- int10--------
    rs1887265711,2
    --9739695(+) AATCTA/GCTCTG 1 -- int10--------
    rs1378985501,2
    C--9739833(+) TATAAC/TTGCTC 1 -- int10--------
    rs758186871,2
    C--9739932(+) ATCCAC/TTCTGC 1 -- int10--------
    rs1471546101,2
    C--9739944(+) GCCCAC/TAGATC 1 -- int10--------
    rs1811580691,2
    --9739983(+) TTATTG/TAAGAA 1 -- int10--------
    rs750667071,2
    F--9740153(+) TTGGAA/GGAAGC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs765537341,2
    C,F--9740174(+) TCTCAT/AGAATG 1 -- int11Minor allele frequency- A:0.13WA 118
    rs1837432341,2
    --9740230(+) ATGTGC/GTAGAA 1 -- int10--------
    rs101774051,2
    C,F,H--9740400(+) acaccG/Attgaa 1 -- int17Minor allele frequency- A:0.04NS NA WA 904
    rs731555231,2
    C,F--9740473(+) GAGGAT/CTGCCT 1 -- int13Minor allele frequency- C:0.10WA CSA 122
    rs39511151,2
    C,F,A--9740561(-) accacG/Acccgg 1 -- int16Minor allele frequency- A:0.45NA WA EA 364
    rs1387349991,2
    --9740573(+) ACTCAC/TGCCTA 1 -- int10--------
    rs1890819941,2
    --9740604(+) CCCAAG/TCGGGC 1 -- int10--------
    rs1427874341,2
    C--9740682(+) ATACAA/GAATTA 1 -- int10--------
    rs1474108121,2
    --9740782(+) TGAGCC/TGAGGT 1 -- int10--------
    rs102020351,2
    C--9740788(+) gaggtC/Tgcgcc 1 -- int10--------
    rs1807533671,2
    C--9740790(+) GGTCGC/TGCCAT 1 -- int10--------
    rs1426812521,2
    --9740791(+) GTCGCA/GCCATT 1 -- int10--------
    rs1872312721,2
    C--9740795(+) CGCCAC/TTGCAC 1 -- int10--------
    rs1506010361,2
    C--9740836(+) TCTCAA/GAAAAA 1 -- int10--------
    rs1396672011,2
    C--9741050(+) TCTATG/TTAAGG 1 -- int10--------
    rs1435988601,2
    C--9741187(+) CTCAAC/TTGTGG 1 -- int10--------
    rs1156833041,2
    C,F--9741192(+) TTGTGG/ATGGTC 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1468058241,2
    C--9741224(+) TAATGC/GTATTT 1 -- int10--------
    rs1159886601,2
    C,F--9741225(+) AATGCT/CATTTA 1 -- int11Minor allele frequency- C:0.09WA 118
    rs1115449281,2
    C,F--9741312(+) CAGGCC/TGGTCA 1 -- int13Minor allele frequency- T:0.08CSA WA NA 240
    rs350003011,2
    C,F--9741463(+) GCGCAC/TGCCTG 1 -- int12Minor allele frequency- T:0.50NA 4
    rs558832491,2
    --9741535(+) GTGAGC/AAGTGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs563723401,2
    --9741536(+) TGAGCA/GGTGAG 1 -- int10--------
    rs67452131,2
    C,F,A--9741546(+) gccagG/Aattgc 1 -- int110Minor allele frequency- A:0.33NA WA CSA 135
    rs1860905451,2
    --9741583(+) AGAGTA/GAAACT 1 -- int10--------
    rs1154880621,2
    C,F--9741689(+) TTAACG/ATTCAT 1 -- int11Minor allele frequency- A:0.08WA 118
    rs1443226861,2
    --9741705(+) AGGTAA/GTAAAA 1 -- int10--------
    rs731555261,2
    C,F--9741742(+) CACACG/ATGATG 1 -- int12Minor allele frequency- A:0.03WA 120
    rs1904127061,2
    --9741748(+) TGATGC/TCATCC 1 -- int10--------
    rs783888751,2
    C,F--9741765(+) AAGAGC/TAGTTC 1 -- int11Minor allele frequency- T:0.09WA 118
    rs97502871,2
    C--9741785(+) tttttA/Tttttt 1 -- int1 trp310Minor allele frequency- T:0.04NA WA CSA EA 371
    rs2009440921,2
    C--9741805(+) TCTCA-/ACTCTG 1 -- int10--------
    rs1826281501,2
    --9741824(+) GGTTGA/GAGTGC 1 -- int10--------
    rs1453292811,2
    C--9742005(+) CTCCTC/GACCTC 1 -- int10--------
    rs621194271,2
    C--9742068(+) CACCAC/TGCCTG 1 -- int110Minor allele frequency- T:0.46NA WA CSA EA 370
    rs1879897521,2
    --9742103(+) CAAAAA/GGTTGT 1 -- int10--------
    rs1492032541,2
    C--9742144(+) GACAAC/TGAACC 1 -- int10--------
    rs1908687721,2
    --9742172(+) AATGCC/TAAAAA 1 -- int10--------
    rs1433931121,2
    --9742439(+) TAAGTC/TCCAGC 1 -- int10--------
    rs1124520791,2
    C--9742640(+) GCACAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs761008151,2
    C--9742752(+) TACTGC/TATCCT 1 -- int10--------
    rs44294461,2
    C,A,H--9742991(+) aaaaaA/Tatata 1 -- int1 trp30--------
    rs118889021,2
    C,F,H--9743035(+) ataGtA/Ggggac 1 -- int16Minor allele frequency- G:0.09NA WA CSA 245
    rs64320241,2
    C,F,A,H--9743134(+) ggcatG/Aagcca 1 -- int116Minor allele frequency- A:0.48NS EA NA WA CSA 791
    rs797145521,2
    F--9743234(+) ATAGGT/CAAACA 1 -- int11Minor allele frequency- C:0.03EA 120
    rs1826723521,2
    --9743245(+) TTCATA/GTAGCT 1 -- int10--------
    rs769630831,2
    C,F--9743267(+) ACAACG/ATAGTC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs621194281,2
    C,F--9743332(+) CAATCT/CGTTCA 1 -- int14Minor allele frequency- C:0.15NA WA 242
    rs1513274381,2
    C--9743340(+) TCAAAC/TATCAT 1 -- int10--------
    rs1888174251,2
    --9743396(+) TCCCTG/TGAATT 1 -- int10--------
    rs1175774611,2
    C,F--9743555(+) AATCAT/CGCCTG 1 -- int11Minor allele frequency- C:0.03EA 120
    rs621194291,2
    C,F--9743585(+) TTTTAG/CAAGAG 1 -- int13Minor allele frequency- C:0.27NA 124
    rs1923138231,2
    --9743661(+) AGCCTA/CCCAAA 1 -- int10--------
    rs1844726241,2
    --9743809(+) ACACTG/TCGGGA 1 -- int10--------
    rs1873134011,2
    --9743813(+) TTCGGA/GAGGCT 1 -- int10--------
    rs1917958381,2
    C--9743872(+) GCATGC/GTGAAA 1 -- int10--------
    rs1840599811,2
    --9743904(+) AAAAAA/GCTAGC 1 -- int10--------
    rs1896983611,2
    --9743964(+) CAAGGC/GAATCT 1 -- int10--------
    rs1406656641,2
    --9744046(+) GACACA/TCCATC 1 -- int10--------
    rs1457858201,2
    --9744178(+) TTACAC/TAGGCC 1 -- int10--------
    rs1387075381,2
    --9744245(+) GCTACA/GCTCCC 1 -- int10--------
    rs1808880451,2
    --9744276(+) GAGAAA/CGGGTA 1 -- int10--------
    rs1842511211,2
    C--9744362(+) ACAAAC/TGAGAG 1 -- int10--------
    rs1427402311,2
    --9744363(+) CAAACG/TAGAGA 1 -- int10--------
    rs1469679991,2
    --9744378(+) AAATAC/TGGGGG 1 -- int10--------
    rs1380327441,2
    --9744503(+) GAACTA/GAAGAC 1 -- int10--------
    rs1905819161,2
    --9744513(+) CACCAA/GTATTT 1 -- int10--------
    rs1495107061,2
    --9744594(+) GAGTAC/TGAGTT 1 -- int10--------
    rs1440995111,2
    C--9744646(+) CATTTA/GACCCT 1 -- int10--------
    rs1486943181,2
    --9744660(+) ACACAA/GGTTTG 1 -- int10--------
    rs1419265911,2
    --9744739(+) ACAACC/TAAACA 1 -- int10--------
    rs1819039931,2
    C--9744773(+) GAGACA/GCAAAA 1 -- int10--------
    rs1862396441,2
    --9744887(+) CAATTA/CCCCTC 1 -- int10--------
    rs1905607471,2
    C--9744910(+) ATGGTC/TATAAT 1 -- int10--------
    rs1417717561,2
    C--9744916(+) ATAAT-/AAAAAA 1 -- int10--------
    rs1815140651,2
    C--9744927(+) AAATTC/GTCCAG 1 -- int1