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Aliases for YWHAQ Gene

Aliases for YWHAQ Gene

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Theta Polypeptide 2 3
  • 14-3-3 Protein T-Cell 3 4
  • 14-3-3 Protein Tau 3 4
  • Protein, Theta 2 3
  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Theta 5
  • Protein Tau 2
  • Protein HS1 4
  • 14-3-3 3
  • HS1 3
  • 1C5 3

External Ids for YWHAQ Gene

Previous GeneCards Identifiers for YWHAQ Gene

  • GC02M009507
  • GC02M009775
  • GC02M009745
  • GC02M009674
  • GC02M009724

Summaries for YWHAQ Gene

Entrez Gene Summary for YWHAQ Gene

  • This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for YWHAQ Gene

YWHAQ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta) is a Protein Coding gene. Diseases associated with YWHAQ include congenital fibrosis of the extraocular muscles and dementia, frontotemporal. Among its related pathways are Cell cycle and Epstein-Barr virus infection. GO annotations related to this gene include protein domain specific binding and protein N-terminus binding. An important paralog of this gene is YWHAZ.

UniProtKB/Swiss-Prot for YWHAQ Gene

  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Tocris Summary for YWHAQ Gene

  • 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.

Gene Wiki entry for YWHAQ Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YWHAQ Gene

Genomics for YWHAQ Gene

Regulatory Elements for YWHAQ Gene

Enhancers for YWHAQ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around YWHAQ on UCSC Golden Path with GeneCards custom track

Promoters for YWHAQ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YWHAQ on UCSC Golden Path with GeneCards custom track

Genomic Location for YWHAQ Gene

Chromosome:
2
Start:
9,583,967 bp from pter
End:
9,631,055 bp from pter
Size:
47,089 bases
Orientation:
Minus strand

Genomic View for YWHAQ Gene

Genes around YWHAQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YWHAQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YWHAQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YWHAQ Gene

Proteins for YWHAQ Gene

  • Protein details for YWHAQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27348-1433T_HUMAN
    Recommended name:
    14-3-3 protein theta
    Protein Accession:
    P27348
    Secondary Accessions:
    • D6W4Z5
    • Q567U5
    • Q5TZU8
    • Q9UP48

    Protein attributes for YWHAQ Gene

    Size:
    245 amino acids
    Molecular mass:
    27764 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK16 (By similarity). Interacts with RGS7 (phosphorylated form) (PubMed:10862767). Interacts with SSH1. Interacts with CDKN1B (Thr-198 phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the Ser-241 phosphorylated form of PDPK1. Interacts with the Thr-369 phosphorylated form of DAPK2 (PubMed:26047703).

    Three dimensional structures from OCA and Proteopedia for YWHAQ Gene

neXtProt entry for YWHAQ Gene

Proteomics data for YWHAQ Gene at MOPED

Post-translational modifications for YWHAQ Gene

  • Ser-232 is probably phosphorylated by CK1.
  • Ubiquitination at Lys 3, Lys 9, Lys 27, Lys 49, Lys 74, and Lys 139
  • Modification sites at PhosphoSitePlus

Other Protein References for YWHAQ Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for YWHAQ (14-3-3 theta)

No data available for DME Specific Peptides for YWHAQ Gene

Domains & Families for YWHAQ Gene

Protein Domains for YWHAQ Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for YWHAQ Gene

Graphical View of Domain Structure for InterPro Entry

P27348

UniProtKB/Swiss-Prot:

1433T_HUMAN :
  • Belongs to the 14-3-3 family.
Family:
  • Belongs to the 14-3-3 family.
genes like me logo Genes that share domains with YWHAQ: view

Function for YWHAQ Gene

Molecular function for YWHAQ Gene

GENATLAS Biochemistry:
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide stratifin,with likely several forms,one expressed in the cytoplasmic of keratinocyte,another in T cells,multifunctional regulator involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
UniProtKB/Swiss-Prot Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Gene Ontology (GO) - Molecular Function for YWHAQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047485 protein N-terminus binding IPI 11984006
genes like me logo Genes that share ontologies with YWHAQ: view
genes like me logo Genes that share phenotypes with YWHAQ: view

Animal Model Products

miRNA for YWHAQ Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for YWHAQ Gene

Localization for YWHAQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for YWHAQ Gene

Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YWHAQ Gene COMPARTMENTS Subcellular localization image for YWHAQ gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
cytoskeleton 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for YWHAQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15163635
GO:0005739 mitochondrion TAS --
genes like me logo Genes that share ontologies with YWHAQ: view

Pathways & Interactions for YWHAQ Gene

genes like me logo Genes that share pathways with YWHAQ: view

SIGNOR curated interactions for YWHAQ Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for YWHAQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021762 substantia nigra development IEP 22926577
GO:0034766 negative regulation of ion transmembrane transport IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 15163635
genes like me logo Genes that share ontologies with YWHAQ: view

Drugs & Compounds for YWHAQ Gene

(2) Additional Compounds for YWHAQ Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Difopein
396834-58-5
R18
211364-78-2

(2) Tocris Compounds for YWHAQ Gene

Compound Action Cas Number
Difopein High affinity inhibitor of 14.3.3 proteins; induces apoptosis 396834-58-5
R18 Inhibitor of 14.3.3 proteins 211364-78-2
genes like me logo Genes that share compounds with YWHAQ: view

Transcripts for YWHAQ Gene

Unigene Clusters for YWHAQ Gene

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for YWHAQ Gene

GeneLoc Exon Structure for
YWHAQ
ECgene alternative splicing isoforms for
YWHAQ

Expression for YWHAQ Gene

mRNA expression in normal human tissues for YWHAQ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YWHAQ Gene



SOURCE GeneReport for Unigene cluster for YWHAQ Gene Hs.74405

mRNA Expression by UniProt/SwissProt for YWHAQ Gene

P27348-1433T_HUMAN
Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
genes like me logo Genes that share expression patterns with YWHAQ: view

Protein tissue co-expression partners for YWHAQ Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for YWHAQ Gene

Orthologs for YWHAQ Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YWHAQ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia YWHAQ 35
  • 94.29 (n)
  • 100 (a)
YWHAQ 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia YWHAQ 35
  • 95.78 (n)
  • 100 (a)
YWHAQ 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia LOC102634437 35
  • 93.88 (n)
  • 99.59 (a)
Ywhaq 16
Ywhaq 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia YWHAQ 35
  • 99.86 (n)
  • 100 (a)
YWHAQ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ywhaq 35
  • 94.29 (n)
  • 99.59 (a)
oppossum
(Monodelphis domestica)
Mammalia YWHAQ 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YWHAQ 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves YWHAQ 35
  • 88.03 (n)
  • 98.78 (a)
YWHAQ 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YWHAQ 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ywhaq 35
  • 72.38 (n)
  • 77.96 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.1068 35
ywhaqb 35
  • 75.92 (n)
  • 82.86 (a)
ywhaqa 36
  • 82 (a)
OneToMany
ywhaqb 36
  • 83 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2365 35
fruit fly
(Drosophila melanogaster)
Insecta 14-3-3zgr 37
  • 77 (a)
14-3-3zeta 36
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ftt-2 36
  • 75 (a)
ManyToMany
par-5 36
  • 73 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.2673 35
Species with no ortholog for YWHAQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YWHAQ Gene

ENSEMBL:
Gene Tree for YWHAQ (if available)
TreeFam:
Gene Tree for YWHAQ (if available)

Paralogs for YWHAQ Gene

Paralogs for YWHAQ Gene

genes like me logo Genes that share paralogs with YWHAQ: view

Variants for YWHAQ Gene

Sequence variations from dbSNP and Humsavar for YWHAQ Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1620756 -- 9,605,728(-) aaaaa(A/T)ttagc intron-variant
rs1630042 -- 9,628,734(+) CGAGC(A/C)ATTCA intron-variant
rs1790036 -- 9,601,852(-) tggcc(A/C)acaca intron-variant
rs1969436 -- 9,610,618(-) ggcag(G/T)agaat intron-variant
rs1969437 -- 9,610,545(-) ggcaa(A/G)aagaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YWHAQ Gene

Variant ID Type Subtype PubMed ID
nsv214045 CNV Loss 16902084

Variation tolerance for YWHAQ Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YWHAQ Gene

HapMap Linkage Disequilibrium report
YWHAQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YWHAQ Gene

Disorders for YWHAQ Gene

MalaCards: The human disease database

(3) MalaCards diseases for YWHAQ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
congenital fibrosis of the extraocular muscles
  • tukel syndrome
dementia, frontotemporal
  • dementia, frontotemporal, with or without parkinsonism
ideomotor apraxia
  • classic apraxia [ambiguous]
- elite association - COSMIC cancer census association via MalaCards
Search YWHAQ in MalaCards View complete list of genes associated with diseases

Relevant External Links for YWHAQ

Genetic Association Database (GAD)
YWHAQ
Human Genome Epidemiology (HuGE) Navigator
YWHAQ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YWHAQ
genes like me logo Genes that share disorders with YWHAQ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for YWHAQ Gene

Publications for YWHAQ Gene

  1. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PMID: 11080204) Malaspina A. … de Belleroche J. (J. Neurochem. 2000) 2 3 4 67
  2. 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. (PMID: 12426317) Nomura M. … Tsujimoto Y. (J. Biol. Chem. 2003) 3 23
  3. 14-3-3IP reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen. (PMID: 25169136) Gao X. … Liu L. (J. Cell. Biochem. 2015) 3
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3

Products for YWHAQ Gene

Sources for YWHAQ Gene

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