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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

YWHAQ Gene

protein-coding GIFtS: 70
GCID: GC02M009724

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...

Explore 25 diseases affiliated with
YWHAQ via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Theta Polypeptide¹ ²		14-3-3 Protein Theta²
14-3-3¹ ²		1C5²
HS1¹ ²		Protein Tau²
14-3-3 Protein T-Cell² ³		Protein HS1³
14-3-3 Protein Tau² ³

External Ids:	HGNC: 12854¹	Entrez Gene: 10971²	Ensembl: ENSG00000134308⁷	OMIM: 609009⁵	UniProtKB: P27348³

Export aliases for YWHAQ gene to outside databases

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745 GC02M009674 GC02M009641

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAQ:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to

phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this

protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral

sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no

correlation between the repeat number and the disease. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling

pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.

Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase

activity of PDPK1

summary for YWHAQ:

14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes

such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3

proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners

including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,

apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,

sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and

heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of

epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can

interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand

binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.

Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the

target that prevent molecular interactions and/or modulate the accessibility of a target protein to

modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a

scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent

an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the

14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,

such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as

Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated

coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus

delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.

Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into

the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are

directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent

growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as

cancer.

Gene Wiki entry for YWHAQ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005334.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the YWHAQ gene promoter:
GR GR-beta MyoD NF-kappaB CREB deltaCREB GR-alpha NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAQ promoter sequence

Search SABiosciences Chromatin IP Primers for YWHAQ

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAQ

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25.2-p25.1

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAQ gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M009724: view genomic region (about GC identifiers)

Start:	9,724,101 bp from pter	End:	9,771,143 bp from pter
Size:	47,043 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348 (See protein sequence)

Recommended Name: 14-3-3 protein theta

Size: 245 amino acids; 27764 Da

Subunit: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198'

phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the

'Ser-241' phosphorylated form of PDPK1

Subcellular location: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals

1 PDB 3D structure from and Proteopedia for YWHAQ:

2BTP (3D)

Secondary accessions: D6W4Z5 Q567U5 Q5TZU8 Q9UP48

Explore the universe of human proteins at neXtProt for YWHAQ: NX_P27348

Post-translational modifications:

Ser-232 is probably phosphorylated by CK1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P27348

YWHAQ Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006817.1

ENSEMBL proteins:

ENSP00000238081 ENSP00000371267 ENSP00000398990

Reactome Protein details: P27348
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for YWHAQ
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IDA	15163635
GO:0005813	centrosome	--	--

YWHAQ for ontologies About GeneDecksing

YWHAQ Antibody Products:

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	Novus Biologicals YWHAQ Antibodies
	Abcam antibodies for YWHAQ
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for YWHAQ

Assay Products for YWHAQ:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

YWHAQ for domains About GeneDecksing

3 InterPro domains/families:

IPR023410 14-3-3_domain

IPR000308 14-3-3

IPR023409 14-3-3_CS

Graphical View of Domain Structure for InterPro Entry P27348

ProtoNet protein and cluster: P27348

1 Blocks protein family: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348

Similarity: Belongs to the 14-3-3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling

pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.

Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase

activity of PDPK1

Genatlas biochemistry entry for YWHAQ:

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide stratifin,with likely several

forms,one expressed in the cytoplasmic of keratinocyte,another in T cells,multifunctional regulator involved in

cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the activation of p38

MAP kinase

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		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAQ (see all 45):
		hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: YWHAQ 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0019904	protein domain specific binding	IEA	--
GO:0047485	protein N-terminus binding	IPI	11984006

YWHAQ for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for YWHAQ:

Decreased telomerase activity

Animal Models:
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ywhaq):

cardiovascular system	cellular	embryogenesis	growth/size	homeostasis/metabolism
mortality/aging	muscle

YWHAQ for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/47 super-pathways (see all 47) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Apoptosis and survival BAD phosphorylation

	Apoptosis and survival BAD phosphorylation	1.00			BAD Phosphorylation	0.41
	Apoptosis and survival_BAD phosphorylation	0.99

Cell cycle_Role of 14-3-3 proteins in cell cycle regulation

	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation	1.00			14-3-3 and Cell Cycle Regulation	0.45
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation	1.00

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

	Activation of BH3-only proteins	0.30			Activation of BAD and translocation to mitochondria	0.15
	Intrinsic Pathway for Apoptosis	0.23

Immune response_Function of MEF2 in T lymphocytes

Immune response_Function of MEF2 in T lymphocytes

1.00

Immune response Function of MEF2 in T lymphocytes

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for YWHAQ

	Immune response Function of MEF2 in T lymphocytes
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Apoptosis and survival BAD phosphorylation

1 R&D Systems Pathway for YWHAQ

Apoptosis Signaling Pathways

19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAQ (see first 5)

	14-3-3 Induced Apoptosis
	DHA Signaling
	PKA Signaling
	ERK5 Signaling
	BDNF Pathway
	IL-3 Pathway
	G2-M Phase Transition
	Akt Signaling
	BAD Phosphorylation
	Insulin Receptor Pathway
	14-3-3 and Cell Cycle Regulation
	Activation of PKA through GPCR
	IGF1R Signaling
	DNA Damage Induced 14-3-3Sigma Signaling
	p70S6K Signaling
	14-3-3 and Regulation of BAD Activity
	cAMP Pathway
	14-3-3 Induced Intracellular Signaling
	Activation of cAMP-Dependent PKA

4 Cell Signaling Technology (CST) Pathways for YWHAQ

	MAP Kinase Signaling
	Apoptosis and Autophagy
	Cell Cycle / Checkpoint Control
	Tyrosine Kinases / Adaptors

2 Tocris Bioscience Pathways for YWHAQ

	Insulin Pathway
	Apoptosis Pathway

4 GeneGo (Thomson Reuters) Pathways for YWHAQ

	Apoptosis and survival BAD phosphorylation
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Immune response Function of MEF2 in T lymphocytes
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation

5/18 BioSystems Pathways for YWHAQ (see all 18)

	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell
	SIDS Susceptibility Pathways
	TNF-alpha/NF-kB Signaling Pathway
	Pathogenic Escherichia coli infection

5/6 Reactome Pathways for YWHAQ (see all 6)

	Activation of BH3-only proteins
	Activation of BAD and translocation to mitochondria
	Intrinsic Pathway for Apoptosis
	Membrane Trafficking
	Translocation of GLUT4 to the Plasma Membrane

4 Kegg Pathways (Kegg details for YWHAQ):

	Cell cycle
	Oocyte meiosis
	Neurotrophin signaling pathway
	Pathogenic Escherichia coli infection

YWHAQ for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for YWHAQ

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/603 Interacting proteins for YWHAQ (P27348^{1, 2, 3} ENSP00000238081⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 603)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805²^,³, ENSP00000352980⁴	MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000352980
HIST2H4A	P62805²^,³, ENSP00000358162⁴	MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000358162
HIST1H4B	P62805²^,³	MINT-7899812 MINT-7900157 I2D: score=2
HIST1H4C	P62805²^,³	MINT-7899812 MINT-7900157 I2D: score=2
HIST1H4D	P62805²^,³	MINT-7899812 MINT-7900157 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	IEA	--
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	IDA	15163635

YWHAQ for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for YWHAQ available from Tocris Bioscience About this table

Compound	Action	CAS #
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

Search CenterWatch for drugs/clinical trials and news about YWHAQ / 1433T

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for YWHAQ gene:

NM_006826.2

Unigene Cluster for YWHAQ:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Hs.74405 [show with all ESTs]

Unigene Representative Sequence: NM_006826

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000238081(uc002qzx.3) ENST00000381844 ENST00000474715 ENST00000446619

ENST00000460093

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		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAQ (see all 45):
		hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: YWHAQ 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAQ (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAQ (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAQ

Additional cDNA sequence:

AF070556.1 AK297624.1 AK302208.1 AK309462.1 AK316158.1 BC050601.1 BC056867.1 BC093019.1

BT020014.1 X56468.1 X57347.1

24/46 DOTS entries (see all 46):

DT.91782977 DT.91898346 DT.100843216 DT.91782983 DT.91728702 DT.95249123 DT.120640215 DT.100884295

DT.95249166 DT.91901902 DT.100884298 DT.86852191 DT.100884268 DT.121011162 DT.100884272 DT.100884302

DT.121011197 DT.121224056 DT.97770024 DT.100804899 DT.100884293 DT.102839040 DT.120640233 DT.91714850

24/1318 AceView cDNA sequences (see all 1318):

AU123463 AA187516 BQ020036 BM769561 BG168166 BM784594 BG942908 BG941467

BI040164 AA084637 CR624722 CN482946 AA303918 AW197189 BI871518 T29254

BE043045 BU189462 BM857142 BE218297 BE909106 BM450841 BG940017 AI369711

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c
SP1:									-				-
SP2:									-				-		-
SP3:									-				-		-		-		-
SP4:									-
SP5:													-

ECgene alternative splicing isoforms for YWHAQ

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

YWHAQ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCATCTCT

About this image

YWHAQ expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See YWHAQ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for YWHAQ

SOURCE GeneReport for Unigene cluster: Hs.74405

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348

Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta.

Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with

controls, with highest levels of expression in individuals with predominant lower motor neuron involvement

SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAQ:

mTOR Signaling in human mouse rat

Synaptic Plasticity in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for YWHAQ gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	YWHAQ¹	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	88.03(n) 98.78(a)		421932 NM_001006415.1 NP_001006415.1
lizard (Anolis carolinensis)	Reptilia	YWHAQ⁶	--	96(a)	1 ↔ 1	1(148386095-148401655)
African clawed frog (Xenopus laevis)	Amphibia	BC044989.1²	--	78.78(n)		BC044989.1
zebrafish (Danio rerio)	Actinopterygii	Dr.1068²	Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more	83.4(n)		BC044412.1
fruit fly (Drosophila melanogaster)	Insecta	14-3-3&zgr;³	RAS protein signal transduction diacylglycerol-activated/phospholipid more	77(a)		--
worm (Caenorhabditis elegans)	Secernentea	ftt-2⁶ par-5⁶ (see all 3)	14-3-3-like protein 1 (see all 3)	76(a) 74(a) (see all 3)	possible ortholog possible ortholog (see all 3)	X(11603640-11605354) IV(11820482-11821901)
thale cress (Arabidopsis thaliana)	eudicotyledons	GRF3⁶ GRF11⁶ (see all 14)	general regulatory factor 11 (see all 14)	58(a) 58(a) (see all 14)	many ↔ many many ↔ many (see all 14)	5(15409697-15411516) 1(12743821-12745648)
rice (Oryza sativa)	Liliopsida	Os.2673²	Rice mRNA for brain specific protein (S94 gene), complete more	77.55(n)		AK062077.1

ENSEMBL Gene Tree for YWHAQ (if available)
TreeFam Gene Tree for YWHAQ (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for YWHAQ gene

YWHAH² YWHAE² YWHAB² YWHAG² SFN² YWHAZ²

9 SIMAP similar genes for YWHAQ using alignment to 4 protein entries: 1433T_HUMAN (see all proteins):

14-3-3 protein YWHAB YWHAZ SFN YWHAH YWHAG

YWHAE YWHAE/FAM22A fusion YWHAE/FAM22B fusion

YWHAQ for paralogs About GeneDecksing

5/9 Pseudogenes.org Pseudogenes for YWHAQ (see all 9)
PGOHUM00000239811 PGOHUM00000239865 PGOHUM00000247782 PGOHUM00000244499 PGOHUM00000240813

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140927829^1,2		--	9723606(+)	`AATAAC/TAGCTA`	1	--	ds500¹		0	--	--	--	--
rs143299486^1,2		--	9723616(+)	`ATTGTG/TATACT`	1	--	ds500¹		0	--	--	--	--
rs11692112^1,2	C,F,H,	--	9723732(+)	`tgacaG/Tgcatt`	1	--	ds500¹		7		NA CSA WA	248
rs190398697^1,2		--	9723803(+)	`AAATTA/GCCTGA`	1	--	ds500¹		0	--	--	--	--
rs151191818^1,2		--	9723813(+)	`AGAGAG/TCCAAC`	1	--	ds500¹		0	--	--	--	--
rs78929674^1,2	F,	--	9723818(+)	`TCCAAC/TGCTTT`	1	--	ds500¹		1		WA	118
rs140341724^1,2		--	9723854(+)	`TGATTG/TTGCCC`	1	--	ds500¹		0	--	--	--	--
rs182611853^1,2		--	9723972(+)	`TGCAAA/TGGGTT`	1	--	ds500¹		0	--	--	--	--
rs7594^1,2	C,F,H,	--	9724267(-)	`ATTGTG/ACATTG`	1	--	ut3¹ ese³		7		NS WA NA	904
rs187680337^1,2		--	9724272(+)	`CACAAC/TGTGGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for YWHAQ (9724101 - 9771143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for YWHAQ
1 CNV: 5969

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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YWHAQ for disorders           About GeneDecksing

OMIM gene information: 609009    OMIM disorders: --

20/25 diseases for YWHAQ (see all 25):    About MalaCards

amyotrophic lateral sclerosis lateral sclerosis guillain-barre syndrome williams-beuren syndrome

amyotrophic lateral sclerosis (als) progressive supranuclear palsy supranuclear palsy frontotemporal dementia

noonan syndrome sporadic breast cancer insulin resistance lipodystrophy

dementia breast cancer seizures lung cancer

ischemia ataxia sarcoma fibrosis

3 diseases from the University of Copenhagen DISEASES database for YWHAQ:

Alzheimer's disease Progressive supranuclear palsy Frontotemporal dementia

Human Genome Epidemiology (HuGE) Navigator: YWHAQ (2 documents)

Export disorders for YWHAQ gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for YWHAQ gene, integrated from 9 sources (see all 222):
(articles sorted by number of sources associating them with YWHAQ)

Utopia: connect your pdf to the dynamic
world of online information

A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PubMed id 11080204)^{1, 2, 3} Malaspina A.... de Belleroche J. (2000)
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)^{1, 2} Brummer T.... Daly R.J. (2008)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{1, 2} Nagata-Ohashi K.... Mizuno K. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)^{1, 2} Fujita N.... Tsuruo T. (2002)
Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)^{1, 2} Sato S....Tsuruo T. (2002)
14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PubMed id 9360956)^{1, 2} Dubois T.... Aitken A. (1997)
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. (PubMed id 7603573)^{1, 2} Xiao B....Gamblin S.J. (1995)
Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)^{1, 2} Leffers H.... Celis J.E. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10971	HGNC: 12854	AceView: YWHAQ	Ensembl:ENSG00000134308	euGenes: HUgn10971
ECgene: YWHAQ	Kegg: 10971	H-InvDB: YWHAQ

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for YWHAQ	Pharmacogenomics, SNPs, Pathways

Intellectual Property for YWHAQ gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for YWHAQ gene:
Search GeneIP for patents involving YWHAQ

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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