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YWHAQ Gene

protein-coding   GIFtS: 70
GCID: GC02M009724

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Theta1 2
     14-3-3 Protein Theta2
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Theta Polypeptide1 2
     1C52
14-3-3 Protein T-Cell2 3     HS12
14-3-3 Protein Tau2 3     Protein HS13
Protein Tau1     TYHAQ5
14-3-32     

External Ids:    HGNC: 128541   Entrez Gene: 109712   Ensembl: ENSG000001343087   OMIM: 6090095   UniProtKB: P273483   

Export aliases for YWHAQ gene to outside databases

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745 GC02M009674 GC02M009641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YWHAQ Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with
amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic,
however, there is no correlation between the repeat number and the disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAQ Gene:
YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta) is a protein-coding gene. Diseases associated with YWHAQ include lateral sclerosis, and noonan syndrome. GO annotations related to this gene include protein N-terminus binding and protein domain specific binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAQ Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAQ gene promoter:
         GR   GR-beta   MyoD   NF-kappaB   CREB   deltaCREB   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAQ promoter sequence
   Search Chromatin IP Primers for YWHAQ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25.2-p25.1

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAQ gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009724:  view genomic region     (about GC identifiers)

Start:
9,724,101 bp from pter      End:
9,771,143 bp from pter
Size:
47,043 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348 (See protein sequence)
Recommended Name: 14-3-3 protein theta  
Size: 245 amino acids; 27764 Da
Subunit: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198'
phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with
the 'Ser-241' phosphorylated form of PDPK1
1 PDB 3D structure from and Proteopedia for YWHAQ:
2BTP (3D)    
Secondary accessions: D6W4Z5 Q567U5 Q5TZU8 Q9UP48

Explore the universe of human proteins at neXtProt for YWHAQ: NX_P27348

Explore proteomics data for YWHAQ at MOPED

Post-translational modifications: 

  • Ser-232 is probably phosphorylated by CK11
  • Ubiquitination2 at Lys9, Lys11, Lys27, Lys49, Lys74, Lys75, Lys80, Lys115, Lys120, Lys122,
                                 Lys139, Lys158
  • Modification sites at PhosphoSitePlus

  • See YWHAQ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006817.1  
    ENSEMBL proteins: 
     ENSP00000371267   ENSP00000238081   ENSP00000398990  
    Reactome Protein details: P27348

    YWHAQ Human Recombinant Protein Products:

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    Novus Biologicals YWHAQ Lysate
    Sino Biological Recombinant Protein for YWHAQ
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for YWHAQ
    Browse Proteins at Cloud-Clone Corp.

    YWHAQ Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAQ
    R&D Systems Antibodies for YWHAQ (14-3-3 theta)
    Cell Signaling Technology (CST) Antibodies for YWHAQ  (14-3-3 theta)
    OriGene Antibodies for YWHAQ
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    Novus Biologicals YWHAQ Antibodies
    Abcam antibodies for YWHAQ
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for YWHAQ
    LSBio Antibodies in human, mouse, rat for YWHAQ

    YWHAQ Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for YWHAQ
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P27348

    ProtoNet protein and cluster: P27348

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Similarity: Belongs to the 14-3-3 family


    YWHAQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433T_HUMAN, P27348
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAQ:
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide stratifin,with likely
    several forms,one expressed in the cytoplasmic of keratinocyte,another in T cells,multifunctional regulator
    involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10954706
    GO:0019904protein domain specific binding IEA--
    GO:0047485protein N-terminus binding IPI11984006
         
    YWHAQ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YWHAQ:
     Decreased telomerase activity 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ywhaq):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle 

    YWHAQ for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YWHAQ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YWHAQ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAQ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAQ

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAQ:
    hsa-mir-1910-5p (MIRT035800), hsa-let-7f-5p (MIRT051373), hsa-mir-1 (MIRT001321), hsa-mir-423-3p (MIRT042637), hsa-mir-328-3p (MIRT043806), hsa-mir-424-5p (MIRT042441), hsa-let-7e-5p (MIRT051526), hsa-mir-214-3p (MIRT024964), hsa-mir-193b-3p (MIRT041385), hsa-mir-93-5p (MIRT048886), hsa-mir-92a-3p (MIRT049225)

    Block miRNA regulation of human, mouse, rat YWHAQ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAQ (see all 45):
    hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidYWHAQ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YWHAQ
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAQ

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for YWHAQ (see all 8)
    OriGene ORF clones in mouse, rat for YWHAQ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YWHAQ (NM_006826)
    Sino Biological Human cDNA Clone for YWHAQ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAQ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAQ

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1433T_HUMAN, P27348: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15163635
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    YWHAQ for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YWHAQ About   (see all 50)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAQ
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAQ (see all 19)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    4 Cell Signaling Technology (CST) Pathways for YWHAQ
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAQ
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAQ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for YWHAQ (see all 19)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Alpha6-Beta4 Integrin Signaling Pathway


    2 Reactome Pathways for YWHAQ
        Activation of BAD and translocation to mitochondria
    Translocation of GLUT4 to the plasma membrane


    Selected Kegg Pathways  (Kegg details for YWHAQ) (see all 8):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Pathogenic Escherichia coli infection


    YWHAQ for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAQ: 
              mTOR Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YWHAQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAQ (P273481, 2, 3 ENSP000002380814) via UniProtKB, MINT, STRING, and/or I2D (see all 760)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628052, 3, ENSP000003581624MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0021762substantia nigra development IEP--
    GO:0045892negative regulation of transcription, DNA-templated IDA15163635

    YWHAQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for YWHAQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for YWHAQ gene: 
    NM_006826.3  

    Unigene Cluster for YWHAQ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
    Hs.74405  [show with all ESTs]
    Unigene Representative Sequence: NM_006826
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381844 ENST00000238081(uc002qzx.3) ENST00000474715 ENST00000446619
    ENST00000460093
    miRNA
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    hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
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      QuantiTect SYBR Green Assays in human, mouse, rat YWHAQ
      QuantiFast Probe-based Assays in human, mouse, rat YWHAQ

    Additional mRNA sequence: 

    AF070556.1 AK297624.1 AK302208.1 AK309462.1 AK316158.1 BC050601.1 BC056867.1 BC093019.1 
    BT020014.1 X56468.1 X57347.1 

    Selected DOTS entries (see all 46):

    DT.91782977  DT.91898346  DT.100843216  DT.91782983  DT.91728702  DT.95249123  DT.120640215  DT.100884295 
    DT.95249166  DT.91901902  DT.100884298  DT.86852191  DT.100884268  DT.121011162  DT.100884272  DT.100884302 
    DT.121011197  DT.121224056  DT.97770024  DT.100804899  DT.100884293  DT.102839040  DT.120640233  DT.91714850 

    1318 AceView cDNA sequences (see top 24):

    BQ217270 CR617682 BQ020036 CF126409 BM839992 CB044802 BM801740 BQ946586 
    BQ421284 AV749894 BM801747 F01519 AA384828 BU619667 AA122357 BM786079 
    X57347 CB134398 BM555413 BU189462 BM857142 BE218297 BM450841 BE909106 
    BG940017 AI369711 BQ691169 BG940319 BQ014764 BG231889 BQ940418 BM753754 
    BQ477503 BQ230568 T16057 BU501304 CR614998 BG253445 BM456958 BE302027 
    BQ224943 BM704112 BM541824 BQ183575 BQ227722 AA084143 BF036398 BQ347546 
    CB149681 BG943895 AA318896 AA345657 BG945021 BM698194 BG500225 BE858161 
    BU164778 R09871 BG284086 BM457589 BE327820 BG258113 CA418505 BU736079 
    AI421876 AV709738 CR594792 BM907326 BQ690095 BM542464 AA357484 AA363565 
    AI828730 CR600718 BQ008523 AA306448 CA449869 BG400791 BQ049976 BQ267890 
    AA333332 AI311538 CB132815 CR613794 BM973397 BM696849 AV730351 M78143 
    BQ445938 BM702376 BM466127 CA441001 AA127073 AI866197 AW976155 AW950286 
    CA431773 BU507432 BE122826 BG770958 BE763143 BM667605 AI718701 BM835947 
    BG120068 CA442384 BE122861 NM_006826 CR591592 BE252232 BM876177 W15345 
    BG675898 BM471435 CA447890 AU127949 BE857562 BQ424911 CB141522 AI830899 
    CR616469 AA454945 H97011 CA440415 BM763551 Z41696 BQ217221 BP340849 
    BE018416 CB120937 CR616856 CA446993 BX424589 AA714131 BQ218177 BM312733 
    BX418112 BM837032 AU118777 BU175970 CR590303 BM698623 BE889589 BG497479 
    CR615240 BG780029 BM451828 AI061383 BG498584 BM788198 CB121110 BM980715 
    BU619498 BQ925373 CA424819 BQ955126 CB123841 BU617026 BQ959790 BQ073560 
    AA601508 AW674407 BG620608 BU735430 BU171850 AA159027 AA782343 BM090941 
    BG168166 BU736260 BM784594 BG941467 BG942908 CR624722 AA084637 CN482946 
    AA303918 AW197189 BE043045 BI871518 T29254 BQ000409 BE783202 CA417427 
    BX477746 BQ055978 BM697061 AI421446 BU187370 BG036044 AL538563 BU948177 
    CA435330 CB141537 BM853341 AA363624 AA464663 BG940080 BU156724 BQ962249 
    BX383383 CA426550 AA363686 BQ671913 AU123463 BQ961973 BQ948659 BU186330 
    CR603466 BM557897 BQ347545 AA323611 AI311121 BI834852 BQ686399 CA413531 
    AV704576 AW768924 BM763317 BU783800 CR620125 BP369903 BI040164 BM999838 
    BQ692017 BM015082 AL697844 BQ883022 BM769561 BF792240 AF070556 CR607940 
    BC050601 BM312423 CB990294 BQ019939 BU149866 BG289952 BM827174 BU567612 
    AA319179 BQ347549 F02134 BM710786 AA455324 CR590208 BG284361 BI858795 
    AA226834 AA187516 BM853326 BM834971 AA778320 BM475163 AA295404 CA394491 
    BM875713 BG771264 BE905518 BQ347547 BM811600 BE746954 BM781890 BG388367 
    AU137567 AI701437 BG700273 BF968990 BE763911 AA528016 BU580090 BG285636 
    BE538989 CB120724 BU181100 BX365255 AA334756 AA558794 BG501802 BG259578 
    BU193133 BF792702 BI547681 BG121454 BM822494 BU183132 BG256315 AI690947 
    BE891422 BE715420 BQ268146 AL110333 AA373722 BG612785 T17106 BG752180 
    BP366924 BM463603 CB159141 BQ230389 AV717729 BX327764 BG546984 BI496242 
    BM978451 AA449168 H97973 BF691319 BQ286677 BU570240 N27863 BG108154 
    CN484653 AA282799 AW674986 BG166212 BI552990 AA336786 AL536438 AI342407 
    BM875674 BG528864 BG773181 BQ219338 BQ422989 CA428258 AA598408 BF036825 
    BG530671 BQ310778 BP337676 BQ573872 BF312118 BM477843 AL533901 AA314500 
    AI088599 BI769637 BG251475 CB997054 BE748112 BG188459 BE855647 BX356381 
    BM480073 BG942598 CF994465 CD520709 BG497632 CB992027 N40636 BX409542 
    BG506186 BG180299 BG708072 W56584 BM988594 AI754876 BX101440 BG216565 
    CR621014 BU948446 BC056867 AI985935 BG720525 AU119206 BM453988 AI828690 
    BG942042 BF036195 BQ576103 CA778172 BX368576 BG259683 H99201 AA122358 
    AI301543 BU928723 AI088540 BM875463 CB993853 AI630076 CF541014 BU186030 
    BI196174 BI086862 BF897817 AA211090 BG716794 BE270662 AU128065 BI857353 
    BE537829 BM970612 AI339193 BX370043 BE787346 BG942938 BG746537 BM800794 
    BG943582 AI340933 BE621278 AW768523 BI763463 BG943923 BG460917 CA416771 
    BE541640 BF061128 AV705085 BG778883 BI457680 BG200297 BX404348 BG676935 
    H99869 AL536878 BM462646 BE900146 N24484 AI003524 BF698533 BG193670 
    AI168121 BU960598 T16213 BE536388 BM469355 CA391765 AW273266 BQ226277 
    AI346661 BX405026 W40586 CD237971 BM476928 BM828504 AI625077 AI478299 
    BG403267 F07296 BX436679 BG197200 BF818983 BM449510 BM848118 BX409544 
    AI368923 BE781968 AA319767 BX383382 BG205521 BF968632 BG253316 AA321880 
    AW338303 AI813775 BG944364 AI160862 AA364710 AI305276 BX380902 BG396324 
    BX440709 AI359013 BF794566 BG284745 BG260799 AW439202 AW769805 AI125530 
    AI422934 AL521928 BQ020676 CB146974 CD641251 BF036783 BG940975 BG391518 
    BI604197 AI003161 AI680649 BF337704 AA330814 BF033629 CA441798 CA447833 
    BQ270016 AL516070 AA206049 AU119161 BF967620 BG214951 BX446891 BM831896 
    BU164956 BG195183 AU137094 BF216243 AA600229 BG503805 BQ428879 AA456958 
    CD245581 BF674636 CB044801 BU630364 BQ212806 BX370042 BQ215717 BG391130 
    BX451171 AI695313 CD640287 BG942985 BP356193 BU183789 AL518598 AA148659 
    AW583570 BM719214 BE538704 BM831309 BG612158 BM470862 BF037983 CB138458 
    AL517566 AA471068 BM793086 BP429353 BG288008 AW074111 BM764032 BU183546 
    D55601 AA364636 W39437 AU133994 AW591852 AW302574 BQ218649 BQ962915 
    BX441662 BF792845 CB114411 C05715 BU629287 BX406400 BP871011 CB115064 
    BF792620 CA777903 BU175542 BG681800 AI819468 N55526 BF309551 BF102570 
    CK002966 BQ347548 AA361709 BM853265 BG742042 BG778812 BU186553 BI869586 
    BE257742 BM876438 BU193578 AI343897 CB146026 BX408085 BM469510 AA371128 
    BM740490 AA113290 BI859380 BE905462 BM477816 AW264253 BG719752 BG502453 
    BU784070 BI596302 BX457973 BF031355 BP376997 BQ436797 AI401230 AA506956 
    BE695704 BI602309 BU729154 BG499619 CA440733 BG503954 BU735986 BF691852 
    BQ614389 W31916 AI274466 AI203966 BG497505 AW583638 AI360107 BF438592 
    BM848212 BG502768 AW057664 BE569017 BU735554 AA186943 AI626113 AI335589 
    BM782031 BX416752 BE885957 AI968490 BG877618 BM747661 CA310228 BF691593 
    BE259527 BG505909 CB997179 BM542773 AI608856 BG533197 AW662515 BG288965 
    CB114976 BG612951 BG171116 CN480724 BM785171 AL537173 AI609095 BG777587 
    AI337975 CB159733 BE779205 AI923353 BU940008 BU191086 BF038551 AA113234 
    BQ065283 CK003081 AW026845 BQ000508 BG528723 CB963729 CA441483 CD521776 
    BM788776 BG612713 BU145564 BI254160 BG199264 AL562042 AA159483 CB996392 
    BQ946444 AI683944 AV725801 BM999828 BU561232 BI258136 AW157223 BI546589 
    BQ070161 BX409496 BP336208 X56468 BQ070846 AA774733 BG036973 BU579843 
    N27621 CF139855 AI348026 BE538680 BQ430617 BF692599 BF316415 AA013022 
    BP378105 N21042 AW273272 BU191038 BI197272 AA916911 BQ654205 BG122496 
    BF525871 BG119887 BF203800 CB986158 BX416599 AA488660 BI601344 AA121998 
    BX365254 BI666830 BG394592 BI458057 AA354350 AV746114 AA384435 AA363551 
    AI819585 BI460573 BG033263 AA531574 R57001 BF096115 H77970 BQ930161 
    AA436120 BE388074 BE695729 BI856141 BE926905 BX337463 BG718063 BG772220 
    AI188500 BF979095 AI199115 AA314345 T40903 AI708686 BF697876 BF841242 
    AA604093 BG435909 BF383012 D52592 R63114 AA206104 BG329825 BG332342 
    BG576183 CA426808 BF681263 R66886 BF664684 BM009320 BG200914 BE397116 
    BF908061 BQ694237 BQ223420 AI682942 BG942459 AI445063 BG755905 BQ214616 
    D53938 BI458208 AL516742 BF664582 BF340797 BG036960 BG165585 BM795932 
    AA070118 BM848178 CF141566 AW590854 AA148658 BF030760 AW105484 BQ276902 
    BM458183 BX330560 N23341 BX395741 AA044791 BE746977 BQ477926 W39297 
    BG702909 BE938277 AV727038 BQ716735 BF241675 CB993580 AI079587 BM845900 
    BQ220227 AV745694 BF669261 BE258886 M85724 AW768692 BM152819 BF668609 
    BF038028 BX451136 AI148758 AA747771 BE796066 CF146367 AV728096 BQ421506 
    AA633997 BE871680 BE785848 D82125 BU151587 AA113158 CA842882 BP379969 
    BE243989 AW474275 BM822726 BQ231721 BG701234 BG216564 BQ951686 AI206380 
    BE561597 BQ927522 CD558115 BP432486 BG708367 AA084169 BE619094 BG192616 
    BI670111 BX409497 BI860304 BI544875 BG481616 BF670909 BE257394 BF770653 
    BG187397 AA548380 AA046846 BF967934 R67971 BE543844 BF217581 BX368690 
    BG506184 N85825 BF033377 AA101101 BG750504 AW246131 W56373 BM541700 
    AA856618 AL516069 N88156 BG169786 BG939173 BI599640 BF692345 AV743507 
    AA223297 AI879106 BE748654 BG212804 BI668397 T30883 BG193671 BF244469 
    AA760846 AI924280 H20725 AA081758 BF240653 AA176262 AW194512 BM014299 
    BE549005 BU074574 AA223866 BU570968 AW771171 AL514792 AA457067 BE547188 
    CB987952 AA332343 BG220625 BF215562 BG679522 BF671186 R68286 AI041611 
    N20626 BF216936 AV740534 AA223271 AA176261 BQ432043 BE926900 AA205683 
    T83358 BI598424 AI565559 BE958527 N28554 R37578 AA362691 BC001197 
    AA614668 BE866115 BI040073 BG704817 BE298373 BF696828 BI459918 AA160336 
    AL514196 AI681587 BE817489 AI719839 AW014563 BQ921598 H85921 CD110342 
    BE270562 AA205495 AV739792 BM046584 BF185187 AA334455 AA776895 AL042788 
    AA081114 BF572168 BF241432 AA205488 H95617 AI367214 BI862506 BM020626 
    AA223289 BI458891 AA304329 CB998810 BE544902 AI262425 BG033151 BE540651 
    BI459802 BE834628 F13652 D53252 BF035251 BF666560 CF147412 AA205483 
    BE866159 BQ218625 BF976928 CB960359 BE545702 AA206105 BE561679 BF028346 
    AA021350 BG877612 BG714869 BX418111 R63072 AA299251 AA858034 BI034785 
    BE927247 W56673 N87121 BG611732 H71492 BE963938 AV723065 W60072 
    AA745800 BG874560 D53024 AA282890 BE504081 BG708008 BF335332 BE172891 
    AA081289 AA352285 BE827132 T11369 AA081518 AW249597 CD696485 BE293977 
    BF666075 BF770623 BF241433 BG117443 BE387897 BF095293 AL536437 BG723400 
    BG723957 BE737733 BF541979 BI603670 AA021245 BF668297 BI668432 BU193026 
    AL516741 BX337464 CF134553 CA749064 BX461873 BE543669 BF307814 BG497628 
    BF037632 BE328304 AL518599 BE269396 AI583013 BG898812 BE885733 BQ350267 
    AA134357 BX380903 BG167788 AA352035 N55217 BU537239 BQ355861 AA988496 
    AA385435 AA125796 AA041249 AA102204 AA113205 D51400 BQ344226 BG388374 
    AA679711 AI246260 BF670144 AA081807 BF977997 AI189105 BF917934 AA263057 
    R40216 BE817629 BE870273 AA044736 AI559808 BI090815 BG389605 AA306412 
    BG168624 AW939510 AW152052 AL039034 H11399 BE926910 AA156388 AA729400 
    AA602820 BU541317 H20656 AV743528 AV754631 BI257423 AI266588 W73328 
    AA114292 AW517934 BE548243 AI077740 AL039155 AW939573 BF909456 AW206693 
    AI204379 BF106383 BQ721393 BF217467 BF311027 BQ717773 BI037003 BF033313 
    AA852970 AI831240 N77009 BG715211 AA333405 D52657 BE961057 AV742538 
    R68328 BF690827 W40562 CB109045 AA336757 BI545138 BG190605 BE926902 
    BE789664 BF132119 BF094411 BE247407 BM043854 H11475 BG501539 R18540 
    AA083520 AW935055 BF247270 W56738 AA148203 BE958442 AW351681 AI721207 
    AL047624 H04159 BX326583 AA486043 BE967581 R18728 AW379999 T86883 
    AV736935 BM450217 R50812 BI545749 AA112402 BQ428002 BE928919 BM049902 
    BF668422 T39947 BG942926 N50473 D51311 AA040809 AW753398 AL566544 
    BG166078 BQ929329 H71493 AW807666 AI873620 R77305 BQ345198 AA226771 
    BE817534 BE559969 BF216997 BG938989 AA248392 BI199728 BG288067 AA156277 
    AA223930 BF130293 BG826652 BG699712 W60998 AA975963 T90617 AA922814 
    AA948643 AI474999 BE887665 BQ670173 D56930 BV179274 C05853 AV741292 
    AA227007 H11374 BF242273 H77971 AI190709 AA224002 AA081910 AI198359 
    N85599 BE928903 AA570287 T90518 AA457239 AW243404 BF088203 AA070117 
    AL533900 BM800744 BX356899 BE270428 BF701445 AV735606 BF210107 AA093262 
    BG701600 AA112514 AA223865 AA219240 D57938 AL515390 AV742954 AA012936 
    BX443364 BE817610 AL517565 R35153 BG674883 BU178439 BF382657 AW245770 
    AA206439 AA206391 AA746251 AA862500 BI767044 BG029613 BF337441 H09915 
    R33513 AA158662 AI432741 AV683552 H09820 BI194823 AL567377 AW896893 
    BQ226872 AA457333 AV742638 AA160443 AI077729 BX356380 BF842343 D55603 
    BG703186 BG704302 BF223951 AA182937 AA587680 H11580 AA976127 AA206529 
    AA160818 BE932701 BE767312 BE936570 BF304441 BI551754 AA513686 BX409241 
    AA158284 BG122847 F13614 BF084876 AW385779 BG989837 T54069 BU166073 
    BE834545 T10660 AA114269 AW896884 H20724 AA159855 AA186906 AW403137 
    AA134356 W52515 BF978459 BF216613 AV736097 AA219379 BE169820 BF242095 
    BF748392 R77261 BF976981 CD250554 AV737574 AV741333 BE242782 AW351674 
    BE936958 AI538664 AA736940 AV725033 BF361277 R21852 H04160 BU171331 
    AV739959 AV736057 BF027833 BE293900 AA211201 R34056 R41528 BG497137 
    BE817637 AV740080 R42089 BF329483 AV739960 AA968480 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                          -           -                                             
    SP2:                          -           -     -                                       
    SP3:                          -           -     -     -     -                           
    SP4:                          -                                                         
    SP5:                                      -                                             


    ECgene alternative splicing isoforms for YWHAQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    YWHAQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCATCTCT
    YWHAQ Expression
    About this image


    YWHAQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
    YWHAQ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAQ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74405

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta.
    Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared
    with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAQ: 
              mTOR Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YWHAQ
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAQ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YWHAQ
    QuantiTect SYBR Green Assays in human, mouse, rat YWHAQ
    QuantiFast Probe-based Assays in human, mouse, rat YWHAQ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAQ gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhaq5
    LOC1026344371
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more5
    14-3-3 protein theta-like1
    93.88(n)1
    99.59(a)1
      12 (8.31 cM)5
    1026344371  XM_006538407.11  XP_006538470.11 
     213900715 
    chicken
    (Gallus gallus)
    Aves YWHAQ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 88.03(n)
    98.78(a)
      421932  NM_001006415.1  NP_001006415.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAQ6
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...
    96(a)
    1 ↔ 1
    1(148381388-148402159)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044989.12   -- 78.78(n)    BC044989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.10682 Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more 83.4(n)    BC044412.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more
    77(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-26
    par-56
    Protein PAR-5 (par-5) mRNA, complete cds
    75(a)
    73(a)
    many ↔ many
    many ↔ many
    X(11603707-11605412) WBGene00001502
    IV(11820505-11821917) WBGene00003920
    rice
    (Oryza sativa)
    Liliopsida Os.26732 Rice mRNA for brain specific protein (S94 gene), complete more 77.55(n)    AK062077.1 


    ENSEMBL Gene Tree for YWHAQ (if available)
    TreeFam Gene Tree for YWHAQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for YWHAQ gene
    YWHAH2  YWHAE2  YWHAB2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAQ using alignment to 4 protein entries:     1433T_HUMAN (see all proteins):
    14-3-3 protein    YWHAZ    YWHAB    SFN    YWHAH    YWHAG
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAQ for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for YWHAQ (see all 9)
    PGOHUM00000239811 PGOHUM00000239865 PGOHUM00000247782 PGOHUM00000244499 PGOHUM00000240813


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YWHAQ (see all 1044)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409278291,2
    --9723606(+) AATAAC/TAGCTA 1 -- ds50010--------
    rs1432994861,2
    C--9723616(+) ATTGTG/TATACT 1 -- ds50010--------
    rs116921121,2
    C,F,H--9723732(+) TGACAG/TGCATT 1 -- ds50017Minor allele frequency- T:0.17NA CSA WA 248
    rs1903986971,2
    --9723803(+) AAATTA/GCCTGA 1 -- ds50010--------
    rs1511918181,2
    C--9723813(+) AGAGAG/TCCAAC 1 -- ds50010--------
    rs789296741,2
    C,F--9723818(+) TCCAAC/TGCTTT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1403417241,2
    C--9723854(+) TGATTG/TTGCCC 1 -- ds50010--------
    rs1826118531,2
    C--9723972(+) TGCAAA/TGGGTT 1 -- ds50010--------
    rs75941,2
    C,F,H--9724267(-) ATTGTG/ACATTG 1 -- ut31 ese37Minor allele frequency- A:0.13NS WA NA 904
    rs1876803371,2
    --9724272(+) CACAAC/TGTGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for YWHAQ (9724101 - 9771143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAQ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv214045CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAQ
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAQ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609009    OMIM disorders: --

    Selected diseases for YWHAQ (see all 29):    
    About MalaCards
    lateral sclerosis    noonan syndrome    guillain-barre syndrome    amyotrophic lateral sclerosis
    progressive supranuclear palsy    williams-beuren syndrome    frontotemporal dementia    lipodystrophy
    sporadic breast cancer    ataxia telangiectasia    dementia    pulmonary function
    ataxia    insulin resistance    meningioma    parkinson's disease
    ischemia    sarcoma    neuroblastoma    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for YWHAQ:
    Alzheimer's disease     Progressive supranuclear palsy     Frontotemporal dementia

    YWHAQ for disorders           About GeneDecksing

    Genetic Association Database (GAD): YWHAQ
    Human Genome Epidemiology (HuGE) Navigator: YWHAQ (2 documents)

    Export disorders for YWHAQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for YWHAQ gene, integrated from 10 sources (see all 259):
    (articles sorted by number of sources associating them with YWHAQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PubMed id 11080204)1, 2, 3 Malaspina A.... de Belleroche J. (J. Neurochem. 2000)
    2. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    4. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (J. Cell Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2 Fujita N.... Tsuruo T. (J. Biol. Chem. 2002)
    8. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)1, 2 Sato S.... Tsuruo T. (J. Biol. Chem. 2002)
    9. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PubMed id 9360956)1, 2 Dubois T.... Aitken A. (J. Biol. Chem. 1997)
    10. Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. (PubMed id 7603573)1, 2 Xiao B....Gamblin S.J. (Nature 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10971 HGNC: 12854 AceView: YWHAQ Ensembl:ENSG00000134308 euGenes: HUgn10971
    ECgene: YWHAQ Kegg: 10971 H-InvDB: YWHAQ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YWHAQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for YWHAQ gene:
    Search GeneIP for patents involving YWHAQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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