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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAQ Gene

protein-coding   GIFtS: 70
GCID: GC02M009724

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Theta Polypeptide1 2
     14-3-3 Protein Theta2
14-3-3 Protein T-Cell2 3     1C52
14-3-3 Protein Tau2 3     HS12
Protein Tau1     Protein HS13
14-3-32     

External Ids:    HGNC: 128541   Entrez Gene: 109712   Ensembl: ENSG000001343087   OMIM: 6090095   UniProtKB: P273483   

Export aliases for YWHAQ gene to outside databases

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745 GC02M009674 GC02M009641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAQ Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with
amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic,
however, there is no correlation between the repeat number and the disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAQ Gene: 
YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide) is a protein-coding gene. Diseases associated with YWHAQ include lateral sclerosis, and amyotrophic lateral sclerosis, and among its related super-pathways are Cell cycle and Cell cycle Role of 14-3-3 proteins in cell cycle regulation. GO annotations related to this gene include protein N-terminus binding and protein domain specific binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAQ Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAQ gene promoter:
         GR   GR-beta   MyoD   NF-kappaB   CREB   deltaCREB   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAQ promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25.2-p25.1

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAQ gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009724:  view genomic region     (about GC identifiers)

Start:
9,724,101 bp from pter      End:
9,771,143 bp from pter
Size:
47,043 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348 (See protein sequence)
Recommended Name: 14-3-3 protein theta  
Size: 245 amino acids; 27764 Da
Subunit: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198'
phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with
the 'Ser-241' phosphorylated form of PDPK1
Subcellular location: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals
1 PDB 3D structure from and Proteopedia for YWHAQ:
2BTP (3D)    
Secondary accessions: D6W4Z5 Q567U5 Q5TZU8 Q9UP48

Explore the universe of human proteins at neXtProt for YWHAQ: NX_P27348

Explore proteomics data for YWHAQ at MOPED 

Post-translational modifications:

  • UniProtKB: Ser-232 is probably phosphorylated by CK1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27348

  • YWHAQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YWHAQ Protein Expression
    REFSEQ proteins: NP_006817.1  
    ENSEMBL proteins: 
     ENSP00000371267   ENSP00000238081   ENSP00000398990  
    Reactome Protein details: P27348
    Human Recombinant Protein Products for YWHAQ: 
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    Sino Biological Recombinant Protein for YWHAQ
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for YWHAQ
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15163635
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane TAS--
    GO:0043234protein complex ----
    GO:0070062extracellular vesicular exosome IDA--

    YWHAQ for ontologies           About GeneDecksing



    YWHAQ Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAQ
    R&D Systems Antibodies for YWHAQ (14-3-3 theta)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry P27348

    ProtoNet protein and cluster: P27348

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Similarity: Belongs to the 14-3-3 family


    YWHAQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433T_HUMAN, P27348
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAQ:
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide stratifin,with likely
    several forms,one expressed in the cytoplasmic of keratinocyte,another in T cells,multifunctional regulator
    involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10954706
    GO:0019904protein domain specific binding IEA--
    GO:0047485protein N-terminus binding IPI11984006
    GO:007188914-3-3 protein binding ----
         
    YWHAQ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YWHAQ:
     Decreased telomerase activity 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ywhaq):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  muscle 

    YWHAQ for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YWHAQ 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAQ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAQ 

    miRNA
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    miRTarBase miRNAs that target YWHAQ:
    hsa-mir-1 (MIRT001321)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAQ
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAQ (see all 45):
    hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidYWHAQ 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for YWHAQ About   (see all 50)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Slit-Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for YWHAQ
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAQ
        Apoptosis Signaling Pathways

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAQ (see all 19)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    4 Cell Signaling Technology (CST) Pathways for YWHAQ
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAQ
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAQ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/19 BioSystems Pathways for YWHAQ (see all 19)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    Alpha6-Beta4 Integrin Signaling Pathway


    5/6        Reactome Pathways for YWHAQ (see all 6)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    5/8         Kegg Pathways  (Kegg details for YWHAQ) (see all 8):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Pathogenic Escherichia coli infection


    YWHAQ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/628 Interacting proteins for YWHAQ (P273481, 2, 3 ENSP000002380814) via UniProtKB, MINT, STRING, and/or I2D (see all 628)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628052, 3, ENSP000003581624MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA15163635
    GO:0097193intrinsic apoptotic signaling pathway TAS--

    YWHAQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    Search CenterWatch for drugs/clinical trials and news about YWHAQ / 1433T

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YWHAQ gene: 
    NM_006826.3  

    Unigene Cluster for YWHAQ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
    Hs.74405  [show with all ESTs]
    Unigene Representative Sequence: NM_006826
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381844 ENST00000238081(uc002qzx.3) ENST00000474715 ENST00000446619
    ENST00000460093

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    Additional mRNA sequence: 

    AF070556.1 AK297624.1 AK302208.1 AK309462.1 AK316158.1 BC050601.1 BC056867.1 BC093019.1 
    BT020014.1 X56468.1 X57347.1 

    24/46 DOTS entries (see all 46):

    DT.91782977  DT.91898346  DT.100843216  DT.91782983  DT.91728702  DT.95249123  DT.120640215  DT.100884295 
    DT.95249166  DT.91901902  DT.100884298  DT.86852191  DT.100884268  DT.121011162  DT.100884272  DT.100884302 
    DT.121011197  DT.121224056  DT.97770024  DT.100804899  DT.100884293  DT.102839040  DT.120640233  DT.91714850 

    1318 AceView cDNA sequences (see top 24):

    BF792240 BU149866 BM475163 BC050601 BI858795 BU567612 CR615240 BG780029 
    BM451828 AI061383 BG498584 BM788198 CB121110 BM980715 F02134 BI871518 
    CB123841 BQ019939 AA084637 BQ955126 BQ347549 BQ925373 AA187516 BE909106 
    AA303918 AW197189 BE043045 BU171850 BM857142 BM667605 AI718701 BM835947 
    BG120068 CA442384 BE122861 NM_006826 CR591592 BE252232 BM876177 W15345 
    BG675898 BM471435 CA447890 AU127949 CA394491 BU189462 CF126409 CB990294 
    AA782343 BU619498 BU736260 AA778320 BM710786 CN482946 BU617026 AI311121 
    BM555413 BQ000409 AI421446 BQ671913 BG289952 CB044802 CR614998 BU501304 
    BG231889 BM753754 BQ014764 BQ940418 BG940319 BQ691169 AI369711 BG620608 
    AW674407 AA601508 BQ073560 BQ959790 AA455324 BM763317 BU783800 CR620125 
    BP369903 BI040164 BM999838 BQ692017 BM015082 AL697844 BM837032 AU118777 
    BU175970 CR590303 BM698623 BE889589 BG497479 BQ961973 BQ946586 BU187370 
    CB141537 BG284361 BI834852 BQ347545 BM853326 BQ230568 BM456958 BE302027 
    BQ224943 BM704112 BM541824 BQ183575 BQ227722 AA084143 BF036398 BQ347546 
    BM312423 T16057 CB149681 BG943895 AA318896 AA345657 BG945021 BM698194 
    BG500225 BE858161 BU164778 R09871 BG284086 BM457589 BE327820 BG258113 
    CA418505 BU736079 AI421876 AV709738 CR594792 BM907326 BQ690095 BM542464 
    AA357484 AA363565 AI828730 CR600718 BQ008523 AA306448 CA449869 BG400791 
    BQ049976 BQ267890 AA333332 BQ217270 BU156724 CA417427 BG940080 BM769561 
    BM786079 CB134398 AL538563 AA363624 BQ948659 BM853341 CR617682 BG036044 
    AI311538 CB132815 CR613794 BM973397 BM696849 AV730351 M78143 BQ445938 
    BM702376 BM466127 CA441001 AA127073 AI866197 AW976155 AW950286 CA431773 
    BU507432 BE122826 BG770958 BE763143 T29254 AA319179 BM090941 AA295404 
    BG940017 BM784594 BU735430 CA424819 CR590208 BM450841 CR624722 BM834971 
    BG941467 BG942908 AF070556 BX477746 BM697061 BQ055978 AU123463 BQ020036 
    X57347 AW768924 BM839992 BQ962249 BM801740 BE857562 BQ424911 CB141522 
    AI830899 CR616469 AA454945 H97011 CA440415 BM763551 Z41696 BQ217221 
    BP340849 BE018416 CB120937 CR616856 CA446993 BX424589 AA714131 BQ218177 
    BM312733 BX418112 BM557897 AA363686 BQ883022 CA426550 CA435330 BU948177 
    BQ421284 AV749894 BE218297 CR603466 AA464663 BE783202 CA413531 AA159027 
    BM827174 BX383383 BU186330 AA323611 BG253445 CR607940 AA226834 BG168166 
    F01519 AA384828 BU619667 AA122357 BM801747 AV704576 BQ686399 BQ477503 
    BQ946444 BI254160 N27621 BG251475 AL562042 AI088599 AV725801 BG777587 
    AL537173 CK003081 BG528723 BX370042 BQ215717 BG391130 BX451171 AI695313 
    CD640287 BG942985 BP356193 BU183789 AL518598 AA148659 AW583570 BM719214 
    BE538704 BM831309 BG612158 BM470862 BF037983 CB138458 BF792620 N27863 
    AL517566 BI496242 BI258136 BQ286677 BG612713 BG288008 AA471068 BP871011 
    BU629287 BI869586 BM463603 BU561232 N55526 BG546984 BM828504 AI625077 
    AI478299 BG403267 F07296 BX436679 BG197200 BF818983 BM449510 BM848118 
    BX409544 AI368923 BE781968 AA319767 BX383382 BG205521 BF968632 BG253316 
    AA321880 AW338303 CB146026 BM811600 BI547681 CB159733 CK002966 CA441483 
    BM788776 BM785171 BX409496 BP336208 BG501802 AA113290 AW074111 AI690947 
    CA777903 BP429353 BF691319 BF038551 D55601 BU183546 BU735554 BE779205 
    AI609095 CN480724 BU191086 BQ347548 AI819468 BG036973 BG742042 BQ070161 
    H97973 AI923353 X56468 BU175542 AA113234 AW157223 BG503954 BE746954 
    W31916 BG166212 AA336786 CN484653 AA282799 AW057664 AA186943 BG285636 
    BU579843 BG388367 BM848212 BF691852 BF031355 BX457973 BM469510 BM781890 
    AI348026 AW674986 BI552990 CF139855 AI337975 BI769637 BQ310778 BG188459 
    BU735986 AA314500 BG530671 BP337676 AL533901 BM477843 BF312118 CA428258 
    BF036825 BG528864 BG773181 BQ219338 BQ422989 AA598408 BM875674 AI342407 
    AL536438 BU729154 BE905518 BQ962915 BQ218649 AW302574 AW591852 AU133994 
    W39437 CB120724 BQ573872 BM747661 CA310228 BF691593 BE259527 BG505909 
    CB997179 BM542773 AI608856 BG533197 AW662515 BG288965 CB114976 BF967620 
    BG214951 BX446891 BM831896 BU164956 BG195183 AU137094 BF216243 AA600229 
    BG503805 BQ428879 AA456958 CD245581 BF674636 CB044801 BU630364 BQ212806 
    BU193133 AW026845 BU145564 BI546589 BI859380 BM876438 BG502768 AA371128 
    AI683944 BG199264 CB997054 BU940008 AA774733 BM480073 BG942598 CF994465 
    CD520709 BG497632 CB992027 N40636 BX409542 BG506186 BG180299 BG708072 
    BI602309 BE748112 W56584 BM988594 AI754876 BX101440 BG216565 CR621014 
    BU948446 BC056867 AI985935 BG720525 AU119206 BM453988 AI828690 BG942042 
    BF036195 BQ576103 CA778172 BX368576 BG259683 H99201 AA122358 AI301543 
    BU928723 AI088540 BM875463 CB993853 AI630076 CF541014 BU186030 BI196174 
    BI086862 BF897817 AA211090 BG716794 BE270662 AU128065 BI857353 BE537829 
    BM970612 AI339193 BX370043 BE787346 BG942938 BG746537 BM800794 BG943582 
    AI340933 BE621278 AW768523 BI763463 BG943923 BG460917 BG612951 BG502453 
    BG719752 AW264253 BU193578 AA506956 BE569017 AI335589 BQ436797 AA334756 
    AI274466 BM875713 T17106 BI596302 BG752180 AU137567 BG771264 BM477816 
    CA416771 BE541640 BF061128 AV705085 BG778883 BI457680 BG200297 BX404348 
    BG676935 H99869 AL536878 BM462646 BE900146 N24484 AI003524 BF698533 
    BG193670 AI168121 BU960598 T16213 BE536388 BM469355 CA391765 AW273266 
    BQ226277 AI346661 BX405026 W40586 CD237971 BM476928 BU570240 BM793086 
    CB115064 AI626113 BM978451 CB114411 AA361709 BG778812 BX327764 AA449168 
    BF309551 BM764032 BF792845 BG108154 BX441662 AI701437 C05715 BQ230389 
    AA364636 BF102570 BM740490 BF438592 CA440733 BU580090 AI343897 AI203966 
    BE763911 CB159141 BE538989 BP366924 BU784070 BQ347547 BG259578 BF968990 
    AA558794 BG499619 AA528016 AI813775 BG944364 AI160862 AA364710 AI305276 
    BX380902 BG396324 BX440709 AI359013 BF794566 BG284745 BG260799 AW439202 
    AW769805 AI125530 AI422934 AL521928 BQ020676 CB146974 CD641251 BF036783 
    BG940975 BG391518 BI604197 AI003161 AI680649 BF337704 AA330814 BF033629 
    CA441798 CA447833 BQ270016 AL516070 AA206049 AU119161 BP376997 BU181100 
    BG497505 BE905462 BX365255 BE695704 BG700273 BQ070846 AW583638 BX408085 
    BQ614389 AI401230 BE257742 BG171116 BX406400 AA159483 BG121454 BE855647 
    BQ065283 BM853265 CD521776 AV717729 BG681800 BU186553 BQ000508 BE891422 
    BE715420 BQ268146 AL110333 BX356381 AA373722 BG612785 BM782031 BX416752 
    BE885957 AI968490 BG877618 CB963729 BM822494 BG256315 BU183132 AI360107 
    BF792702 CB996392 BM999828 AI879106 BI599640 BG394592 BI458057 AA176262 
    AV746114 BE871680 BQ477926 W39297 BG702909 BE938277 AV727038 BQ716735 
    BF241675 CB993580 M85724 AI079587 BI197272 BG119887 BQ223420 AI682942 
    BG942459 AI445063 BG755905 N85825 AA013022 AA223866 BF692345 BF240653 
    AA081758 AW474275 AA457067 BE748654 AW771171 BU151587 AW768692 AA223297 
    BX409497 H20725 AV743507 AI924280 AA113158 AL514792 BU570968 AA760846 
    BF669261 BE785848 CB987952 BI668397 BM822726 BE561597 BI670111 BI860304 
    BQ951686 CB986158 BX416599 AA121998 BI601344 BI666830 AA488660 AA633997 
    BQ421506 AV728096 CF146367 BE796066 AA747771 AI148758 BX451136 BF038028 
    BF668609 BM152819 BG750504 AW246131 W56373 BM541700 AA856618 AL516069 
    N88156 BX330560 N23341 BX395741 AA044791 BE746977 AA354350 BF967934 
    BG192616 AW194512 AA084169 AA384435 AA363551 AI819585 BI460573 BG033263 
    AA531574 R57001 BF096115 H77970 BG193671 BQ930161 AA436120 BE388074 
    BE695729 BI856141 BE926905 BX337463 BG718063 BG772220 AI188500 BF979095 
    AI199115 AA314345 T40903 AI708686 BF697876 BF841242 AA604093 BG435909 
    BF383012 D52592 R63114 AA206104 BG329825 BG332342 BG576183 CA426808 
    CD558115 BQ927522 BG220625 BG169786 BF316415 BG708367 BF670909 BG506184 
    BE538680 BQ231721 BF681263 R66886 BF664684 BM009320 BG200914 BE397116 
    BF908061 BQ694237 BF203800 BE549005 BP379969 BQ220227 BM014299 BF525871 
    CA842882 D82125 BG122496 BF244469 BG701234 BE543844 R67971 AA548380 
    BX368690 AA046846 BF217581 BU191038 AI206380 BF692599 BG216564 BE619094 
    BF770653 BQ214616 D53938 BI458208 AL516742 BF664582 BF340797 BG036960 
    BG165585 BM795932 AA070118 BM848178 CF141566 AW590854 AA148658 BF030760 
    AW105484 BQ276902 BM458183 AA332343 BG939173 BI544875 BG481616 BG212804 
    BQ430617 BG187397 BM845900 AA916911 BQ654205 T30883 BX365254 BE547188 
    BE258886 BU074574 BE243989 N21042 AW273272 BF033377 AA101101 AV745694 
    BE257394 BP378105 BP432486 BF307814 BE269396 AA206105 BE561679 BF028346 
    AA021350 BG877612 BG714869 BX418111 R63072 AA299251 AI041611 BG898812 
    BM020626 AA223289 BI458891 AA304329 CB998810 BE544902 AI262425 BG497628 
    BX461873 BQ350267 CA749064 CF134553 BE885733 AA223271 AL518599 BE504081 
    AA205683 BF770623 AL536437 BF671186 BX380903 BG708008 R68286 AA081289 
    BF541979 N28554 BI598424 BE958527 AI565559 T83358 H71492 BG611732 
    N87121 W56673 BE927247 AA021245 BF668297 BI668432 BU193026 AL516741 
    CB960359 BE545702 BF216936 BF037632 BE387897 AI583013 BE543669 AA282890 
    R37578 AA362691 BC001197 AA614668 BE866115 BI040073 N20626 BG704817 
    BE298373 BF696828 BI459918 AA160336 AL514196 AI681587 BE817489 AI719839 
    AW014563 BQ921598 H85921 CD110342 BE270562 AA205495 AV739792 BM046584 
    BF185187 AA334455 BX337464 BE172891 BF335332 AA081518 BE293977 AW249597 
    BG117443 BG723400 AA776895 AL042788 AA081114 BF572168 BF241432 AA205488 
    H95617 AI367214 BI862506 BI034785 AA176261 AA745800 BQ432043 CD696485 
    AA858034 BE926900 BE963938 AV723065 BG874560 D53024 BF241433 BF666075 
    BG679522 BF095293 AA134357 BF215562 AA352285 BG033151 BE540651 BI459802 
    BE834628 F13652 D53252 BF035251 BF666560 CF147412 AA205483 BE866159 
    BQ218625 BF976928 T11369 BE827132 W60072 BG723957 BE737733 BE328304 
    AV740534 BI603670 N55217 H04159 AA083520 AI721207 AI204379 BF106383 
    BQ721393 BQ717773 BF033313 BF247270 AI831240 N77009 BU541317 H20656 
    AV743528 AV754631 BI257423 AV742538 AA852970 W56738 BI037003 AA125796 
    AW351681 AA102204 R68328 AA113205 AI246260 AA679711 BG388374 D51400 
    W40562 BF217467 AL047624 BE247407 BM043854 H11475 BG501539 BF909456 
    AW206693 BI545138 BF132119 R18540 BG167788 BF670144 AA081807 BF977997 
    AI189105 BF917934 AA263057 R40216 BE817629 BE870273 AA044736 AI559808 
    BI090815 BG389605 AA306412 BE961057 BF690827 AA352035 BG168624 AW939510 
    AW152052 AL039034 H11399 BE926910 AA156388 AA729400 AA602820 AA041249 
    BG715211 BE958442 AA333405 BF311027 AA385435 BG190605 BE926902 BX326583 
    D52657 AI266588 W73328 AA114292 AW517934 BE548243 AI077740 AL039155 
    AW939573 AA486043 CB109045 AA148203 BE789664 BQ344226 AW935055 AA988496 
    BQ355861 BU537239 BF094411 AA336757 N85599 AI190709 AA570287 AA227007 
    AA156277 AV736935 H71493 AW807666 AI873620 R77305 BQ345198 C05853 
    BE928903 BF242273 AA224002 AA112402 BI545749 BE928919 BQ428002 R50812 
    T90617 AA223930 BM049902 BQ670173 D56930 BV179274 BG288067 W60998 
    AA081910 BF668422 AI474999 H11374 AI198359 H77971 AA922814 T39947 
    BG942926 N50473 D51311 AA040809 AW753398 AL566544 BG166078 AW379999 
    AA948643 BQ929329 BG699712 BM450217 BG826652 BE967581 R18728 AA226771 
    BE817534 BE559969 BF216997 BG938989 AA248392 BI199728 AA975963 BF130293 
    T86883 BE887665 AV741292 AA160443 AI077729 AA158662 AI432741 AV683552 
    AA746251 AA862500 BI767044 BQ226872 BI194823 AA976127 T90518 BG703186 
    D55603 BE270428 BX356899 AA457333 AW896893 AL567377 BG704302 BF223951 
    AA182937 H09915 R33513 AA587680 AA206529 AA457239 BF701445 AV735606 
    BF210107 AA093262 BG701600 AA112514 AA223865 AA219240 D57938 AL515390 
    AV742954 AA012936 BX443364 BE817610 AL517565 R35153 BG674883 BU178439 
    BF382657 AW245770 AA206439 AA206391 H09820 BM800744 AV742638 AW243404 
    BX356380 BG029613 BF337441 BF088203 H11580 BF842343 AA070117 AL533900 
    AW403137 W52515 BU166073 BE834545 T10660 BF978459 AI538664 AW351674 
    AV736097 AA219379 AA513686 BE932701 AA134356 R77261 BF976981 CD250554 
    H20724 AA159855 AA186906 BX409241 BE936958 AV741333 AA158284 BG122847 
    F13614 BF216613 BE936570 BE767312 BF084876 AW385779 BG989837 T54069 
    BE242782 AV737574 BF242095 AA160818 AA114269 AW896884 BE169820 AA736940 
    BF304441 BI551754 BF748392 BE817637 AA211201 R42089 AV725033 BF361277 
    H04160 AV739960 BF329483 BU171331 AA968480 AV739959 AV736057 BF027833 
    BE293900 AV740080 R34056 R41528 BG497137 R21852 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                          -           -                                             
    SP2:                          -           -     -                                       
    SP3:                          -           -     -     -     -                           
    SP4:                          -                                                         
    SP5:                                      -                                             


    ECgene alternative splicing isoforms for YWHAQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAQ expression in normal human tissues (normalized intensities)      YWHAQ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCATCTCT
    YWHAQ Expression
    About this image


    YWHAQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Kidney (Urinary System)
             visceral organ/mesonephros/mesonephric mesenchyme   

    See YWHAQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAQ

    SOURCE GeneReport for Unigene cluster: Hs.74405

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta.
    Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared
    with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement

        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAQ: 
              mTOR Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YWHAQ
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAQ
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAQ
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAQ
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAQ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAQ gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhaq1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.74(n)1
    99.59(a)1
      12 (8.31 cM)5
    226301  NM_011739.31  NP_035869.11 
     213900715 
    chicken
    (Gallus gallus)
    Aves YWHAQ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 88.03(n)
    98.78(a)
      421932  NM_001006415.1  NP_001006415.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAQ6
    Uncharacterized protein
    96(a)
    1 ↔ 1
    1(148381388-148402159)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044989.12   -- 78.78(n)    BC044989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.10682 Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more 83.4(n)    BC044412.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more
    77(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-26
    par-56
    14-3-3-like protein 1
    75(a)
    73(a)
    many ↔ many
    many ↔ many
    X(11603707-11605421)
    IV(11820505-11821924)
    rice
    (Oryza sativa)
    Liliopsida Os.26732 Rice mRNA for brain specific protein (S94 gene), complete more 77.55(n)    AK062077.1 


    ENSEMBL Gene Tree for YWHAQ (if available)
    TreeFam Gene Tree for YWHAQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAQ gene
    YWHAH2  YWHAE2  YWHAB2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAQ using alignment to 4 protein entries:     1433T_HUMAN (see all proteins):
    14-3-3 protein    YWHAB    YWHAZ    SFN    YWHAH    YWHAG
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAQ for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for YWHAQ (see all 9)
    PGOHUM00000239811 PGOHUM00000239865 PGOHUM00000247782 PGOHUM00000244499 PGOHUM00000240813


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1044 SNPs in YWHAQ are shown (see all 1044)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409278291,2
    --9723606(+) AATAAC/TAGCTA 1 -- ds50010--------
    rs1432994861,2
    C--9723616(+) ATTGTG/TATACT 1 -- ds50010--------
    rs116921121,2
    C,F,H--9723732(+) TGACAG/TGCATT 1 -- ds50017Minor allele frequency- T:0.17NA CSA WA 248
    rs1903986971,2
    --9723803(+) AAATTA/GCCTGA 1 -- ds50010--------
    rs1511918181,2
    C--9723813(+) AGAGAG/TCCAAC 1 -- ds50010--------
    rs789296741,2
    C,F--9723818(+) TCCAAC/TGCTTT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1403417241,2
    C--9723854(+) TGATTG/TTGCCC 1 -- ds50010--------
    rs1826118531,2
    C--9723972(+) TGCAAA/TGGGTT 1 -- ds50010--------
    rs75941,2
    C,F,H--9724267(-) ATTGTG/ACATTG 1 -- ut31 ese37Minor allele frequency- A:0.13NS WA NA 904
    rs1876803371,2
    --9724272(+) CACAAC/TGTGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for YWHAQ (9724101 - 9771143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAQ:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv214045CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609009    OMIM disorders: --

    20/25 diseases for YWHAQ (see all 25):    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    guillain-barre syndrome    noonan syndrome
    progressive supranuclear palsy    williams-beuren syndrome    lipodystrophy    frontotemporal dementia
    sporadic breast cancer    ataxia telangiectasia    dementia    hiv type 1
    insulin resistance    ataxia    ischemia    schizophrenia
    parkinson's disease    sarcoma    neuroblastoma    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for YWHAQ:
    Alzheimer's disease     Progressive supranuclear palsy     Frontotemporal dementia

    YWHAQ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): YWHAQ
    Human Genome Epidemiology (HuGE) Navigator: YWHAQ (2 documents)

    Export disorders for YWHAQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAQ gene, integrated from 9 sources (see all 251):
    (articles sorted by number of sources associating them with YWHAQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PubMed id 11080204)1, 2, 3 Malaspina A.... de Belleroche J. (2000)
    2. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    4. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2 Fujita N.... Tsuruo T. (2002)
    8. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)1, 2 Sato S....Tsuruo T. (2002)
    9. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PubMed id 9360956)1, 2 Dubois T.... Aitken A. (1997)
    10. Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. (PubMed id 7603573)1, 2 Xiao B....Gamblin S.J. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10971 HGNC: 12854 AceView: YWHAQ Ensembl:ENSG00000134308 euGenes: HUgn10971
    ECgene: YWHAQ Kegg: 10971 H-InvDB: YWHAQ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YWHAQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YWHAQ gene:
    Search GeneIP for patents involving YWHAQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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