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YWHAQ Gene

protein-coding   GIFtS: 70
GCID: GC02M009724

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
  See YWHAQ-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Theta1 2
     14-3-3 Protein Theta2
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Theta Polypeptide1 2
     1C52
14-3-3 Protein T-Cell2 3     HS12
14-3-3 Protein Tau2 3     Protein HS13
Protein Tau1     TYHAQ5
14-3-32     

External Ids:    HGNC: 128541   Entrez Gene: 109712   Ensembl: ENSG000001343087   OMIM: 6090095   UniProtKB: P273483   

Export aliases for YWHAQ gene to outside databases

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745 GC02M009674 GC02M009641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YWHAQ Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with
amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic,
however, there is no correlation between the repeat number and the disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAQ Gene:
YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta) is a protein-coding gene. Diseases associated with YWHAQ include amyotrophic lateral sclerosis. GO annotations related to this gene include protein N-terminus binding and protein domain specific binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAQ Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAQ gene promoter:
         GR   GR-beta   MyoD   NF-kappaB   CREB   deltaCREB   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAQ promoter sequence
   Search Chromatin IP Primers for YWHAQ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25.2-p25.1

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAQ gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009724:  view genomic region     (about GC identifiers)

Start:
9,724,101 bp from pter      End:
9,771,143 bp from pter
Size:
47,043 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348 (See protein sequence)
Recommended Name: 14-3-3 protein theta  
Size: 245 amino acids; 27764 Da
Subunit: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198'
phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with
the 'Ser-241' phosphorylated form of PDPK1
1 PDB 3D structure from and Proteopedia for YWHAQ:
2BTP (3D)    
Secondary accessions: D6W4Z5 Q567U5 Q5TZU8 Q9UP48

Explore the universe of human proteins at neXtProt for YWHAQ: NX_P27348

Explore proteomics data for YWHAQ at MOPED

Post-translational modifications: 

  • Ser-232 is probably phosphorylated by CK11
  • Ubiquitination2 at Lys9, Lys11, Lys27, Lys49, Lys74, Lys75, Lys80, Lys115, Lys120, Lys122,
                                 Lys139, Lys158
  • Modification sites at PhosphoSitePlus

  • See YWHAQ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006817.1  
    ENSEMBL proteins: 
     ENSP00000371267   ENSP00000238081   ENSP00000398990  
    Reactome Protein details: P27348

    YWHAQ Human Recombinant Protein Products:

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    Novus Biologicals YWHAQ Lysate
    Sino Biological Recombinant Protein for YWHAQ
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for YWHAQ 

    YWHAQ Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAQ
    R&D Systems Antibodies for YWHAQ (14-3-3 theta)
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    OriGene Antibodies for YWHAQ
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    Novus Biologicals YWHAQ Antibodies
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    LSBio Antibodies in human, mouse, rat for YWHAQ

    YWHAQ Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for YWHAQ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry P27348

    ProtoNet protein and cluster: P27348

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Similarity: Belongs to the 14-3-3 family


    Find genes that share domains with YWHAQ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433T_HUMAN, P27348
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAQ:
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide stratifin,with likely
    several forms,one expressed in the cytoplasmic of keratinocyte,another in T cells,multifunctional regulator
    involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10954706
    GO:0019904protein domain specific binding IEA--
    GO:0047485protein N-terminus binding IPI11984006
         
    Find genes that share ontologies with YWHAQ           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for YWHAQ:
     Decreased telomerase activity 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ywhaq):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle 

    Find genes that share phenotypes with YWHAQ           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YWHAQ
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAQ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAQ

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAQ:
    hsa-mir-1910-5p (MIRT035800), hsa-let-7f-5p (MIRT051373), hsa-mir-1 (MIRT001321), hsa-mir-423-3p (MIRT042637), hsa-mir-328-3p (MIRT043806), hsa-mir-424-5p (MIRT042441), hsa-let-7e-5p (MIRT051526), hsa-mir-214-3p (MIRT024964), hsa-mir-193b-3p (MIRT041385), hsa-mir-93-5p (MIRT048886), hsa-mir-92a-3p (MIRT049225)

    Block miRNA regulation of human, mouse, rat YWHAQ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAQ (see all 45):
    hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidYWHAQ 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat YWHAQ

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    GenScript: all cDNA clones in your preferred vector: YWHAQ (NM_006826)
    Sino Biological Human cDNA Clone for YWHAQ
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    Addgene plasmids for YWHAQ 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    1433T_HUMAN, P27348: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15163635
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with YWHAQ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YWHAQ About   (see all 50)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56


    Find genes that share SuperPaths with YWHAQ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAQ
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAQ (see all 19)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    4 Cell Signaling Technology (CST) Pathways for YWHAQ
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAQ
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAQ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for YWHAQ (see all 19)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Alpha6-Beta4 Integrin Signaling Pathway


    2 Reactome Pathways for YWHAQ
        Activation of BAD and translocation to mitochondria
    Translocation of GLUT4 to the plasma membrane


    Selected Kegg Pathways  (Kegg details for YWHAQ) (see all 8):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAQ: 
              mTOR Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YWHAQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAQ (P273481, 2, 3 ENSP000002380814) via UniProtKB, MINT, STRING, and/or I2D (see all 760)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628052, 3, ENSP000003581624MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0021762substantia nigra development IEP--
    GO:0045892negative regulation of transcription, DNA-templated IDA15163635

    Find genes that share ontologies with YWHAQ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for YWHAQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for YWHAQ gene: 
    NM_006826.3  

    Unigene Cluster for YWHAQ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
    Hs.74405  [show with all ESTs]
    Unigene Representative Sequence: NM_006826
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381844 ENST00000238081(uc002qzx.3) ENST00000474715 ENST00000446619
    ENST00000460093
    miRNA
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    hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
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      QuantiTect SYBR Green Assays in human, mouse, rat YWHAQ
      QuantiFast Probe-based Assays in human, mouse, rat YWHAQ

    Additional mRNA sequence: 

    AF070556.1 AK297624.1 AK302208.1 AK309462.1 AK316158.1 BC050601.1 BC056867.1 BC093019.1 
    BT020014.1 X56468.1 X57347.1 

    Selected DOTS entries (see all 46):

    DT.91782977  DT.91898346  DT.100843216  DT.91782983  DT.91728702  DT.95249123  DT.120640215  DT.100884295 
    DT.95249166  DT.91901902  DT.100884298  DT.86852191  DT.100884268  DT.121011162  DT.100884272  DT.100884302 
    DT.121011197  DT.121224056  DT.97770024  DT.100804899  DT.100884293  DT.102839040  DT.120640233  DT.91714850 

    Selected AceView cDNA sequences (see all 1318):

    BQ217270 CR617682 BQ020036 CF126409 BM839992 CB044802 BM801740 BQ946586 
    BQ421284 AV749894 BM801747 F01519 AA384828 BU619667 AA122357 BM786079 
    X57347 CB134398 BM555413 BU189462 BM857142 BE218297 BM450841 BE909106 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                          -           -                                             
    SP2:                          -           -     -                                       
    SP3:                          -           -     -     -     -                           
    SP4:                          -                                                         
    SP5:                                      -                                             


    ECgene alternative splicing isoforms for YWHAQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    YWHAQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCATCTCT
    YWHAQ Expression
    About this image


    YWHAQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
    YWHAQ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAQ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74405

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta.
    Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared
    with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAQ: 
              mTOR Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YWHAQ
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAQ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YWHAQ
    QuantiTect SYBR Green Assays in human, mouse, rat YWHAQ
    QuantiFast Probe-based Assays in human, mouse, rat YWHAQ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAQ gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhaq5
    LOC1026344371
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more5
    14-3-3 protein theta-like1
    93.88(n)1
    99.59(a)1
      12 (8.31 cM)5
    1026344371  XM_006538407.11  XP_006538470.11 
     213900715 
    chicken
    (Gallus gallus)
    Aves YWHAQ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 88.03(n)
    98.78(a)
      421932  NM_001006415.1  NP_001006415.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAQ6
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...
    96(a)
    1 ↔ 1
    1(148381388-148402159)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044989.12   -- 78.78(n)    BC044989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.10682 Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more 83.4(n)    BC044412.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more
    77(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-26
    par-56
    Protein PAR-5 (par-5) mRNA, complete cds
    75(a)
    73(a)
    many ↔ many
    many ↔ many
    X(11603707-11605412) WBGene00001502
    IV(11820505-11821917) WBGene00003920
    rice
    (Oryza sativa)
    Liliopsida Os.26732 Rice mRNA for brain specific protein (S94 gene), complete more 77.55(n)    AK062077.1 


    ENSEMBL Gene Tree for YWHAQ (if available)
    TreeFam Gene Tree for YWHAQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for YWHAQ gene
    YWHAH2  YWHAE2  YWHAB2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAQ using alignment to 4 protein entries:     1433T_HUMAN (see all proteins):
    14-3-3 protein    YWHAZ    YWHAB    SFN    YWHAH    YWHAG
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    Find genes that share paralogs with YWHAQ           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for YWHAQ (see all 9)
    PGOHUM00000239811 PGOHUM00000239865 PGOHUM00000247782 PGOHUM00000244499 PGOHUM00000240813


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YWHAQ (see all 1044)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409278291,2
    --9723606(+) AATAAC/TAGCTA 1 -- ds50010--------
    rs1432994861,2
    C--9723616(+) ATTGTG/TATACT 1 -- ds50010--------
    rs116921121,2
    C,F,H--9723732(+) TGACAG/TGCATT 1 -- ds50017Minor allele frequency- T:0.17NA CSA WA 248
    rs1903986971,2
    --9723803(+) AAATTA/GCCTGA 1 -- ds50010--------
    rs1511918181,2
    C--9723813(+) AGAGAG/TCCAAC 1 -- ds50010--------
    rs789296741,2
    C,F--9723818(+) TCCAAC/TGCTTT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1403417241,2
    C--9723854(+) TGATTG/TTGCCC 1 -- ds50010--------
    rs1826118531,2
    C--9723972(+) TGCAAA/TGGGTT 1 -- ds50010--------
    rs75941,2
    C,F,H--9724267(-) ATTGTG/ACATTG 1 -- ut31 ese37Minor allele frequency- A:0.13NS WA NA 904
    rs1876803371,2
    --9724272(+) CACAAC/TGTGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for YWHAQ (9724101 - 9771143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAQ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv214045CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAQ
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAQ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609009    OMIM disorders: --

    1 disease for YWHAQ:    
    About MalaCards
    amyotrophic lateral sclerosis

    3 diseases from the University of Copenhagen DISEASES database for YWHAQ:
    Alzheimer's disease     Progressive supranuclear palsy     Frontotemporal dementia

    Find genes that share disorders with YWHAQ           About GenesLikeMe

    Genetic Association Database (GAD): YWHAQ
    Human Genome Epidemiology (HuGE) Navigator: YWHAQ (2 documents)

    Export disorders for YWHAQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for YWHAQ gene, integrated from 10 sources (see all 259) (see top 10):
    (articles sorted by number of sources associating them with YWHAQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PubMed id 11080204)1, 2, 3 Malaspina A.... de Belleroche J. (J. Neurochem. 2000)
    2. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    4. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (J. Cell Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2 Fujita N.... Tsuruo T. (J. Biol. Chem. 2002)
    8. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)1, 2 Sato S.... Tsuruo T. (J. Biol. Chem. 2002)
    9. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PubMed id 9360956)1, 2 Dubois T.... Aitken A. (J. Biol. Chem. 1997)
    10. Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. (PubMed id 7603573)1, 2 Xiao B....Gamblin S.J. (Nature 1995)
    11. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)1, 2 Leffers H.... Celis J.E. (J. Mol. Biol. 1993)
    12. Primary structure of a human protein kinase regulator protein. (PubMed id 2015305)1, 2 Nielsen P.J. (Biochim. Biophys. Acta 1991)
    13. 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. (PubMed id 12426317)1, 9 Nomura M....Tsujimoto Y. (J. Biol. Chem. 2003)
    14. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    15. Identification of a novel ATPase activity in 14-3-3 proteins--evidence from enzyme kinetics, structure guided modeling and mutagenesis studies. (PubMed id 24269678)1 Ramteke M.P....Venkatraman P. (FEBS Lett. 2014)
    16. 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. (PubMed id 23774214)1 Oh S....Janknecht R. (Cancer Res. 2013)
    17. The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation. (PubMed id 23333852)1 Meijer I.M....van Leeuwen J.E. (Cell. Signal. 2013)
    18. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    19. Negative regulation of the RalGAP complex by 14-3-3. (PubMed id 23386617)1 Leto D....Saltiel A.R. (J. Biol. Chem. 2013)
    20. A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. (PubMed id 23938468)1 Lin A.E....Cristea I.M. (amp 2013)
    21. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)
    22. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
    23. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    24. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    25. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    26. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    27. 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function. (PubMed id 22575644)1 Bai Y....Huang B. (FEBS Lett. 2012)
    28. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. (PubMed id 22649097)1 Xu C.... Min J. (Sci. Signal. 2012)
    29. A neuronal transmembrane protein LRFN4 complexes with 14-3-3s and NCK1 to induce morphological change in monocytic cells via Rac1-mediated actin cytoskeleton reorganization. (PubMed id 22677168)1 Konakahara S....Kohroki J. (FEBS Lett. 2012)
    30. Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID? (PubMed id 22115752)1 Hodgkinson V.C....Cawkwell L. (J Proteomics 2012)
    31. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    32. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    33. The progesterone-responsive gene 14-3-3I8 enhances the transcriptional activity of progesterone receptor in uterine cells. (PubMed id 22967481)1 Ito M....Taketani Y. (J. Mol. Endocrinol. 2012)
    34. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. (PubMed id 22466704)1 Li J....Herrup K. (Nat. Med. 2012)
    35. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. (PubMed id 22863277)1 Yu F.X....Guan K.L. (Cell 2012)
    36. Isoform-specific immunolocalization of 14-3-3 proteins in atherosclerotic lesions of human carotid and main cerebral arteries. (PubMed id 22405925)1 Umahara T....Iwamoto T. (J. Neurol. Sci. 2012)
    37. [Degradation of 14-3-3beta appeared in apoptosis cell induced by PrP106-126 polypeptide]. (PubMed id 22978167)1 Sun P....Han J. (Bing Du Xue Bao 2012)
    38. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    39. ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration. (PubMed id 22580824)1 Joseph N....Mishima M. (EMBO J. 2012)
    40. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes. (PubMed id 22462548)1 Henriksson E....GAPransson O. (Biochem. J. 2012)
    41. Oligomeric structure of 14-3-3 protein: what do we know about monomers? (PubMed id 23159940)1 Sluchanko N.N. and Gusev N.B. (FEBS Lett. 2012)
    42. The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode. (PubMed id 22952583)1 Hu S.H....Martin J.L. (PLoS ONE 2012)
    43. Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. (PubMed id 22174390)1 Rankinen T....Bouchard C. (J. Appl. Physiol. 2012)
    44. The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. (PubMed id 22612223)1 Rudenko I.N....Cookson M.R. (Biochem. J. 2012)
    45. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    46. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. (PubMed id 22797923)1 Hoxhaj G....MacKintosh C. (J. Cell. Sci. 2012)
    47. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    48. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    49. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    50. 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. (PubMed id 22222486)1 Andersen S.D....Rasmussen L.J. (DNA Repair (Amst.) 2012)
    51. Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years. (PubMed id 23012332)1 Stoeck K....Zerr I. (Brain 2012)
    52. The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor-mediated Rho kinase signalling. (PubMed id 22010828)1 Arulpragasam A....Ward B.K. (Biochem. J. 2012)
    53. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    54. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    55. Probable participation of 14-3-3 in tau protein oligomerization and aggregation. (PubMed id 21876254)1 Sluchanko N.N. and Gusev N.B. (J. Alzheimers Dis. 2011)
    56. NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. (PubMed id 21555462)1 Habbig S....Schermer B. (J. Cell Biol. 2011)
    57. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1 Jiang W.... Zhao S. (Mol. Cell 2011)
    58. The phytotoxin fusicoccin promotes platelet aggregation via 14-3-3-glycoprotein Ib-IX-V interaction. (PubMed id 21395556)1 Camoni L....Aducci P. (Biochem. J. 2011)
    59. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    60. A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage. (PubMed id 21118956)1 Okada N....Nojima H. (J. Cell. Sci. 2011)
    61. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. (PubMed id 21900244)1 Chandran S....Bhalla V. (J. Biol. Chem. 2011)
    62. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    63. Differential expression of 14-3-3 isoforms in human alcoholic brain. (PubMed id 21332526)1 MacKay R.K....Lewohl J.M. (Alcohol. Clin. Exp. Res. 2011)
    64. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    65. Identification and functional characterization of 14-3-3 in TLR2 signaling. (PubMed id 21827211)1 Schuster T.B....Ahmad-Nejad P. (J. Proteome Res. 2011)
    66. An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins. (PubMed id 21209461)1 Hoek M....Stillman B. (J. Biol. Chem. 2011)
    67. Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function. (PubMed id 22027839)1 Rezabkova L....Obsil T. (J. Biol. Chem. 2011)
    68. Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. (PubMed id 21624135)1 Rajendran P....Dashwood R.H. (Mol. Cancer 2011)
    69. The phosphatidylinositol transfer protein RdgBI^ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II typeA I receptor-associated protein). (PubMed id 21728994)1 Garner K....Cockcroft S. (Biochem. J. 2011)
    70. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    71. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    72. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    73. MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. (PubMed id 21152872)1 Sun B.K....Song J.J. (Oncol. Rep. 2011)
    74. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    75. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    76. The role of 14-3-3I^ in transcriptional activation of estrogen receptor I+ and its involvement in proliferation of breast cancer cells. (PubMed id 21946067)1 Kim Y....Ko J. (Biochem. Biophys. Res. Commun. 2011)
    77. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    78. Differential protein expression level identification by knockout of 14-3-3I8 with siRNA technique and 2DE followed MALDI-TOF-TOF-MS. (PubMed id 21046037)1 Jin H....Yang P.Y. (Analyst 2011)
    79. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)1 Greco T.M....Cristea I.M. (amp 2011)
    80. Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model. (PubMed id 21655264)1 Okamoto Y....Takahashi R. (PLoS ONE 2011)
    81. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. (PubMed id 20642453)1 Nichols R.J....Alessi D.R. (Biochem. J. 2010)
    82. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. (PubMed id 20110348)1 Singh A....Khosravi-Far R. (Mol. Biol. Cell 2010)
    83. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    84. Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival. (PubMed id 19996285)1 Vazquez A....Bond G.L. (Cancer Res. 2010)
    85. Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization. (PubMed id 19933840)1 Robens J.M....Manser E. (Mol. Cell. Biol. 2010)
    86. PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. (PubMed id 20716686)1 Ha C.H....Jin Z.G. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    87. 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. (PubMed id 20086099)1 Wang B....Lin W.C. (Mol. Cell. Biol. 2010)
    88. The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum. (PubMed id 20308060)1 Nakamura T....Akiyama T. (J. Biol. Chem. 2010)
    89. The expression of seven 14-3-3 isoforms in human meningioma. (PubMed id 20388496)1 Liu Y....Zhang X. (Brain Res. 2010)
    90. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-I^-SMAD pathway. (PubMed id 21145499)1 Varelas X....Wrana J.L. (Dev. Cell 2010)
    91. Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome. (PubMed id 19935702)1 Cockrell L.M....Fu H. (Oncogene 2010)
    92. 14-3-3 mediated regulation of the tumor suppressor protein, RASSF1A. (PubMed id 20069457)1 Ghazaleh H.A....Baksh S. (Apoptosis 2010)
    93. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    94. Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. (PubMed id 20451386)1 Douglas M.E....Mishima M. (Curr. Biol. 2010)
    95. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. (PubMed id 20679480)1 Molzan M....Ottmann C. (Mol. Cell. Biol. 2010)
    96. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (FEBS J. 2010)
    97. 14-3-3Tau regulates Beclin 1 and is required for autophagy. (PubMed id 20454448)1 Wang B....Lin W.C. (PLoS ONE 2010)
    98. SLy2 targets the nuclear SAP30/HDAC1 complex. (PubMed id 20478393)1 Brandt S....Beer-Hammer S. (amp 2010)
    99. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    100. 14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4. (PubMed id 19416966)1 Silhan J....Obsil T. (J. Biol. Chem. 2009)
    101. A 20-amino acid module of protein kinase C{epsilon} involved in translocation and selective targeting at cell-cell contacts. (PubMed id 19429675)1 Diouf B....Joubert D. (J. Biol. Chem. 2009)
    102. Vpr and its interactions with cellular proteins. (PubMed id 20012529)1 Planelles V. and Benichou S. (Curr. Top. Microbiol. Immunol. 2009)
    103. Human immunodeficiency virus type 1 Vpr: functions and molecular interactions. (PubMed id 19458171)1 Romani B. and Engelbrecht S. (J. Gen. Virol. 2009)
    104. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    105. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. (PubMed id 19592491)1 Jang S.W.... Ye K. (J. Biol. Chem. 2009)
    106. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    107. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    108. The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. (PubMed id 19553522)1 Lin J....Shaw A.S. (J. Immunol. 2009)
    109. Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. (PubMed id 19139046)1 Zuzarte M....Preisig-MA1ller R. (J. Physiol. (Lond.) 2009)
    110. Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. (PubMed id 19786833)1 Hervouet E....Cartron P.F. (Epigenetics 2009)
    111. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    112. Isoform-specific cleavage of 14-3-3 proteins in apoptotic JURL-MK1 cells. (PubMed id 19173300)1 KuzelovA! K....Hrkal Z. (J. Cell. Biochem. 2009)
    113. Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes. (PubMed id 19801645)1 Halskau A.9....Martinez A. (J. Biol. Chem. 2009)
    114. Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets. (PubMed id 19558434)1 Mangin P.H....Lanza F. (J. Thromb. Haemost. 2009)
    115. p62 protects SH-SY5Y neuroblastoma cells against H2O2-induced injury through the PDK1/Akt pathway. (PubMed id 19010391)1 Heo S.R....Joung I. (Neurosci. Lett. 2009)
    116. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    117. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    118. Human immunodeficiency virus type 1 gp120-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. (PubMed id 18569453)1 Nakamuta S....Kido H. (J. Neurovirol. 2008)
    119. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    120. Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding. (PubMed id 18550856)1 Takala H....Fagerholm S.C. (Blood 2008)
    121. 14-3-3 regulates the nuclear import of class IIa histone deacetylases. (PubMed id 18952052)1 Nishino T.G....Yoshida M. (Biochem. Biophys. Res. Commun. 2008)
    122. 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation. (PubMed id 18059471)1 Winter S....Seiser C. (EMBO J. 2008)
    123. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. (PubMed id 17973628)1 Winge I....Haavik J. (Biochem. J. 2008)
    124. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    125. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. (PubMed id 18332145)1 Chen C....White M.A. (J. Biol. Chem. 2008)
    126. AMPK phosphorylation of raptor mediates a metabolic checkpoint. (PubMed id 18439900)1 Gwinn D.M.... Shaw R.J. (Mol. Cell 2008)
    127. GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells. (PubMed id 18292392)1 Pang J....Berk B.C. (Arterioscler. Thromb. Vasc. Biol. 2008)
    128. The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. (PubMed id 18215133)1 Fonseca B.D....Proud C.G. (Biochem. J. 2008)
    129. Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera. (PubMed id 18794547)1 Qiu J....Hanash S.M. (J. Clin. Oncol. 2008)
    130. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (J. Proteome Res. 2008)
    131. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PubMed id 18779327)1 Courchet J.... Billaud M. (J. Biol. Chem. 2008)
    132. Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. (PubMed id 18249187)1 Jin Y.H....Lee K.Y. (Biochem. Biophys. Res. Commun. 2008)
    133. Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. (PubMed id 19011111)1 Watkins J.L....Piwnica-Worms H. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    134. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    135. Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. (PubMed id 18356162)1 Lopez-Pajares V....Yuan Z.M. (J. Biol. Chem. 2008)
    136. [Proportion of tau protein to phosphorylated tau protein CSF levels in differential diagnosis of dementia]. (PubMed id 18626620)1 Hort J....Stourac P. (Nervenarzt 2008)
    137. 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr. (PubMed id 18445273)1 Bolton D.L....Lenardo M.J. (Biol. Direct 2008)
    138. A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. (PubMed id 17979178)1 Gloeckner C.J....Ueffing M. (Proteomics 2007)
    139. p27Kip1 localization depends on the tumor suppressor protein tuberin. (PubMed id 17470459)1 Rosner M....HengstschlAoger M. (Hum. Mol. Genet. 2007)
    140. Purification and identification of G protein-coupled receptor protein complexes under native conditions. (PubMed id 17215244)1 Daulat A.M....Jockers R. (amp 2007)
    141. Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding. (PubMed id 17913709)1 Kim J.-S.... Bokoch G.M. (J. Biol. Chem. 2007)
    142. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    143. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    144. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    145. Molecular characterization of the HIV type 1 subtype C accessory genes vif, vpr, and vpu. (PubMed id 17331040)1 Bell C.M....Papathanasopoulos M.A. (AIDS Res. Hum. Retroviruses 2007)
    146. 14-3-3 integrates pro-survival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1 transformed hematopoietic cells. (PubMed id 17389761)1 Dong S.... Chen J. (Blood 2007)
    147. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)1 Koch H.B....Hermeking H. (Cell Cycle 2007)
    148. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
    149. Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle. (PubMed id 17369524)1 Howlett K.F....Hargreaves M. (Diabetes 2007)
    150. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. (PubMed id 17617058)1 Geraghty K.M....MacKintosh C. (Biochem. J. 2007)
    151. An emerin &quot;proteome&quot;: purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (Biochemistry 2007)
    152. Gatekeeper role of 14-3-3tau protein in HIV-1 gp120-mediated apoptosis of human endothelial cells by inactivation of Bad. (PubMed id 17457084)1 Yano M....Kido H. (AIDS 2007)
    153. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    154. Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. (PubMed id 17369396)1 Parra M....Verdin E. (amp 2007)
    155. RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. (PubMed id 17389591)1 Zhang H.... Min W. (J. Biol. Chem. 2007)
    156. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)1 Camargo L.M....Brandon N.J. (Mol. Psychiatry 2007)
    157. Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer. (PubMed id 18089831)1 Pereira-Faca S.R....Hanash S.M. (Cancer Res. 2007)
    158. New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. (PubMed id 16368544)1 Calinisan V....Gascard P. (Front. Biosci. 2006)
    159. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    160. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1 Dequiedt F.... Kettmann R. (Mol. Cell. Biol. 2006)
    161. CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s. (PubMed id 16956611)1 Gao C....Kao H.Y. (FEBS Lett. 2006)
    162. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. (PubMed id 16775625)1 Gao Y.... Chen J. (Cell Res. 2006)
    163. Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. (PubMed id 16943424)1 Pereg Y....Jochemsen A.G. (Mol. Cell. Biol. 2006)
    164. Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members. (PubMed id 16868027)1 GAPdde N.J....Novak U. (J. Cell. Sci. 2006)
    165. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. (PubMed id 16511560)1 LeBron C....Chen J. (EMBO J. 2006)
    166. Structural basis for protein-protein interactions in the 14-3-3 protein family. (PubMed id 17085597)2 Yang X.... Elkins J.M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    167. CPAP interacts with 14-3-3 in a cell cycle-dependent manner. (PubMed id 16516142)1 Chen C.Y....Tang T.K. (Biochem. Biophys. Res. Commun. 2006)
    168. MDMX regulation of p53 response to ribosomal stress. (PubMed id 17110929)1 Gilkes D.M....Chen J. (EMBO J. 2006)
    169. Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization. (PubMed id 16367866)1 Patel A....Connerton I. (Cell. Microbiol. 2006)
    170. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. (PubMed id 16679322)1 Pulina M.V....Carafoli E. (J. Biol. Chem. 2006)
    171. Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression. (PubMed id 16581770)1 Gong W....Riabowol K. (Mol. Cell. Biol. 2006)
    172. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (Cell 2006)
    173. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 16888623)1 Raina D....Kufe D. (EMBO J. 2006)
    174. Detection of CSF 14-3-3 protein in Guillain-BarrAc syndrome. (PubMed id 17190946)1 Bersano A....Nobile-Orazio E. (Neurology 2006)
    175. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    176. Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3. (PubMed id 16176975)1 Brock C....Pin J.P. (Mol. Biol. Cell 2005)
    177. Involvement of protein kinase PKN1 in G2/M delay caused by arsenite. (PubMed id 15791647)1 Isagawa T....Ono Y. (Mol. Carcinog. 2005)
    178. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. (PubMed id 15629715)1 Manke I.A.... Yaffe M.B. (Mol. Cell 2005)
    179. BCR kinase phosphorylates 14-3-3 Tau on residue 233. (PubMed id 16045749)1 Clokie S.J....Aitken A. (FEBS J. 2005)
    180. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. (PubMed id 15902271)1 Pan F....Liu J.O. (EMBO J. 2005)
    181. Large-scale analysis of the human ubiquitin-related proteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (Proteomics 2005)
    182. Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. (PubMed id 16041367)1 Rajalingam K....Rudel T. (Nat. Cell Biol. 2005)
    183. Molecular characterization of ring finger protein 11. (PubMed id 16123141)1 Connor M.K.... Seth A.K. (Mol. Cancer Res. 2005)
    184. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. (PubMed id 15964851)1 Wang A.H....Yang X.J. (J. Biol. Chem. 2005)

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    Entrez Gene: 10971 HGNC: 12854 AceView: YWHAQ Ensembl:ENSG00000134308 euGenes: HUgn10971
    ECgene: YWHAQ Kegg: 10971 H-InvDB: YWHAQ

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    PharmGKB entry for YWHAQ Pharmacogenomics, SNPs, Pathways

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