YWHAQ Gene

Aliases
for YWHAQ gene

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745 GC02M009674 GC02M009641

Summaries
for YWHAQ gene

Genomic Views
for YWHAQ gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_005334.16  

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAQ promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAQ

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009724:  view genomic region     (about GC identifiers)

Proteins
for YWHAQ gene

1 PDB 3D structure from and Proteopedia for YWHAQ:

2BTP (3D)    

Explore the universe of human proteins at neXtProt for YWHAQ: NX_P27348

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for YWHAQ
	OriGene Purified Protein: YWHAQ OriGene Protein Over-expression Lysate: YWHAQ OriGene Custom Protein Services for YWHAQ
	GenScript Custom Purified and Recombinant Proteins Services for YWHAQ
	Novus Biologicals YWHAQ Proteins Novus Biologicals YWHAQ Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for YWHAQ
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAQ
	R&D Systems Antibodies for YWHAQ (14-3-3 theta)
	Cell Signaling Technology (CST) Antibodies for YWHAQ  (14-3-3 theta)
	OriGene Antibodies: YWHAQ OriGene Custom Antibody Services for YWHAQ
	GenScript Custom Superior Antibodies Services for YWHAQ
	Novus Biologicals YWHAQ Antibodies
	Abcam antibodies for YWHAQ
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for YWHAQ

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for YWHAQ
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for YWHAQ gene

ProtoNet protein and cluster: P27348

Function
for YWHAQ gene

miRNA Products:		miRTarBase miRNAs that target YWHAQ: hsa-mir-1 (MIRT001321)
		OriGene 3'-UTR Clone: YWHAQ Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAQ
		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAQ (see all 45):
		hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
		SwitchGear 3'UTR luciferase reporter plasmid: YWHAQ 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAQ (see all 7) OriGene shRNA RFP: YWHAQ OriGene siRNA: YWHAQ
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAQ

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for YWHAQ

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAQ (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAQ (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: YWHAQ (NM_006826)
		Sino Biological Human cDNA Clone for YWHAQ
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAQ

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for YWHAQ
		Search LifeMap BioReagents cell lines for YWHAQ

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Ywhaq)

Pathways & Interactions
for YWHAQ gene

	Super-pathway	contained gene-specific pathways
1	Activation of cAMP-Dependent PKA	Activation of cAMP-Dependent PKA 1.00 Activation of PKA through GPCR 0.71 cAMP Pathway 0.77 PKA Signaling 0.56
2	Apoptosis and survival BAD phosphorylation	Apoptosis and survival BAD phosphorylation 1.00 BAD Phosphorylation 0.41 Apoptosis and survival_BAD phosphorylation 0.99
3	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation	Cell cycle_Role of 14-3-3 proteins in cell cycle regulation 1.00 14-3-3 and Cell Cycle Regulation 0.45 Cell cycle Role of 14-3-3 proteins in cell cycle regulation 1.00
4	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	Activation of BH3-only proteins 0.30 Activation of BAD and translocation to mitochondria 0.15 Intrinsic Pathway for Apoptosis 0.23
5	Immune response_Function of MEF2 in T lymphocytes	Immune response_Function of MEF2 in T lymphocytes 1.00 Immune response Function of MEF2 in T lymphocytes 0.90

4 EMD Millipore Pathways for YWHAQ

	Immune response Function of MEF2 in T lymphocytes
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Apoptosis and survival BAD phosphorylation

1 R&D Systems Pathway for YWHAQ

Apoptosis Signaling Pathways

5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAQ

	14-3-3 Induced Apoptosis
	DHA Signaling
	PKA Signaling
	ERK5 Signaling
	BDNF Pathway

4 Cell Signaling Technology (CST) Pathways for YWHAQ

	MAP Kinase Signaling
	Apoptosis and Autophagy
	Cell Cycle / Checkpoint Control
	Tyrosine Kinases / Adaptors

2 Tocris Bioscience Pathways for YWHAQ

	Insulin Pathway
	Apoptosis Pathway

4 GeneGo (Thomson Reuters) Pathways for YWHAQ

	Apoptosis and survival BAD phosphorylation
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Immune response Function of MEF2 in T lymphocytes
	Cell cycle Role of 14-3-3 proteins in cell cycle regulation

5/18 BioSystems Pathways for YWHAQ

	Myometrial Relaxation and Contraction Pathways
	Calcium Regulation in the Cardiac Cell
	SIDS Susceptibility Pathways
	TNF-alpha/NF-kB Signaling Pathway
	Pathogenic Escherichia coli infection

5/6        Reactome Pathways for YWHAQ

	Activation of BH3-only proteins
	Activation of BAD and translocation to mitochondria
	Intrinsic Pathway for Apoptosis
	Membrane Trafficking
	Translocation of GLUT4 to the Plasma Membrane

4         Kegg Pathways  (Kegg details for YWHAQ)

	Cell cycle
	Oocyte meiosis
	Neurotrophin signaling pathway
	Pathogenic Escherichia coli infection

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for YWHAQ gene

Transcripts
for YWHAQ gene

Expression
for YWHAQ gene

YWHAQ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCATCTCT

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Endoderm-like cells (Generation of hepato...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAQ Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAQ
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAQ
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAQ

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ

Orthologs
for YWHAQ gene

Paralogs
for YWHAQ gene

Paralogs for YWHAQ gene

YWHAH²  YWHAE²  YWHAB²  YWHAG²  SFN²  YWHAZ²  

9 SIMAP similar genes for YWHAQ using alignment to 4 protein entries:     1433T_HUMAN (see all proteins):

14-3-3 protein    YWHAB    YWHAZ    SFN    YWHAH    YWHAG

YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

YWHAQ for paralogs           About GeneDecksing


5/9 Pseudogenes.org Pseudogenes for YWHAQ (see all 9)
PGOHUM00000239811 PGOHUM00000239865 PGOHUM00000247782 PGOHUM00000244499 PGOHUM00000240813

Genomic Variants
for YWHAQ gene

10/867 NCBI SNPs in YWHAQ are shown (see all 867)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1409278291,2		--	9723606(+)	AATAAC/TAGCTA	1	--	ds5001		0	--	--	--	--
rs1432994861,2		--	9723616(+)	ATTGTG/TATACT	1	--	ds5001		0	--	--	--	--
rs116921121,2	C,F,H,	--	9723732(+)	tgacaG/Tgcatt	1	--	ds5001		7		NA CSA WA	248
rs1903986971,2		--	9723803(+)	AAATTA/GCCTGA	1	--	ds5001		0	--	--	--	--
rs1511918181,2		--	9723813(+)	AGAGAG/TCCAAC	1	--	ds5001		0	--	--	--	--
rs789296741,2	F,	--	9723818(+)	TCCAAC/TGCTTT	1	--	ds5001		1		WA	118
rs1403417241,2		--	9723854(+)	TGATTG/TTGCCC	1	--	ds5001		0	--	--	--	--
rs1826118531,2		--	9723972(+)	TGCAAA/TGGGTT	1	--	ds5001		0	--	--	--	--
rs75941,2	C,F,H,	--	9724267(-)	ATTGTG/ACATTG	1	--	ut31 ese3		7		NS WA NA	904
rs1876803371,2		--	9724272(+)	CACAAC/TGTGGA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for YWHAQ (9724101 - 9771143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for YWHAQ
     1 CNV: 5969

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YWHAQ

DNA2.0 Custom Variant and Variant Library Synthesis for YWHAQ

Disorders / Diseases
for YWHAQ gene

Publications
for YWHAQ gene

PubMed articles for YWHAQ gene, integrated from 9 sources (see all 222) (see top 10): (articles sorted by number of sources associating them with YWHAQ)

Utopia: connect your pdf to the dynamic world of online information

1. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PubMed id 11080204)^{1, 2, 3} Malaspina A.... de Belleroche J. (2000)
2. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)^{1, 2} Brummer T.... Daly R.J. (2008)
3. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{1, 2} Nagata-Ohashi K.... Mizuno K. (2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
6. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)^{1, 2} Fujita N.... Tsuruo T. (2002)
7. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)^{1, 2} Sato S....Tsuruo T. (2002)
8. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PubMed id 9360956)^{1, 2} Dubois T.... Aitken A. (1997)
9. Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. (PubMed id 7603573)^{1, 2} Xiao B....Gamblin S.J. (1995)
10. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)^{1, 2} Leffers H.... Celis J.E. (1993)
11. Primary structure of a human protein kinase regulator protein. (PubMed id 2015305)^{1, 2} Nielsen P.J. (1991)
12. 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. (PubMed id 12426317)^{1, 9} Nomura M....Tsujimoto Y. (2003)
13. 14-3-3 interacts with LKB1 via recognizing phosphoryla ted threonine 336 residue and suppresses LKB1 kinase function. (PubMed id 22575644)¹ Bai Y....Huang B. (2012)
14. The weak complex between RhoGAP protein ARHGAP22 and s ignal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide bindi ng mode. (PubMed id 22952583)¹ Hu S.H....Martin J.L. (2012)
15. Sequence-specific recognition of a PxLPxI/L motif by a n ankyrin repeat tumbler lock. (PubMed id 22649097)¹ Xu C....Min J. (2012)
16. Heritability of submaximal exercise heart rate respons e to exercise training is accounted for by nine SNPs. (PubMed id 22174390)¹ Rankinen T....Bouchard C. (2012)
17. The G2385R variant of leucine-rich repeat kinase 2 ass ociated with Parkinson's disease is a partial loss-of-function mutation. (PubMed id 22612223)¹ Rudenko I.N....Cookson M.R. (2012)
18. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
19. ZNRF2 is released from membranes by growth factors and , together with ZNRF1, regulates the Na+/K+ATPase. (PubMed id 22797923)¹ Hoxhaj G....MacKintosh C. (2012)
20. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (2012)
21. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
22. A neuronal transmembrane protein LRFN4 complexes with 14-3-3s and NCK1 to induce morphological change in monocytic cells via Rac1-medi ated actin cytoskeleton reorganization. (PubMed id 22677168)¹ Konakahara S....Kohroki J. (2012)
23. 14-3-3 checkpoint regulatory proteins interact specif ically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. (PubMed id 22222486)¹ Andersen S.D....Rasmussen L.J. (2012)
24. Proteomic identification of predictive biomarkers of r esistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID? (PubMed id 22115752)¹ Hodgkinson V.C....Cawkwell L. (2012)
25. Nuclear accumulation of HDAC4 in ATM deficiency promot es neurodegeneration in ataxia telangiectasia. (PubMed id 22466704)¹ Li J....Herrup K. (2012)
26. Isoform-specific immunolocalization of 14-3-3 proteins in atherosclerotic lesions of human carotid and main cerebral arteries. (PubMed id 22405925)¹ Umahara T....Iwamoto T. (2012)
27. [Degradation of 14-3-3beta appeared in apoptosis cell induced by PrP106-126 polypeptide]. (PubMed id 22978167)¹ Sun P....Han J. (2012)
28. Cerebrospinal fluid biomarker supported diagnosis of C reutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study o ver 10 years. (PubMed id 23012332)¹ Stoeck K....Zerr I. (2012)
29. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
30. ARF6 GTPase protects the post-mitotic midbody from 14- 3-3-mediated disintegration. (PubMed id 22580824)¹ Joseph N....Mishima M. (2012)
31. The adaptor protein 14-3-3 binds to the calcium-sensin g receptor and attenuates receptor-mediated Rho kinase signalling. (PubMed id 22010828)¹ Arulpragasam A....Ward B.K. (2012)
32. The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358 in adipocytes. (PubMed id 22462548)¹ Henriksson E....Goransson O. (2012)
33. Oligomeric structure of 14-3-3 protein: what do we kno w about monomers? (PubMed id 23159940)¹ Sluchanko N.N. and Gusev N.B. (2012)
34. Structural basis for the 14-3-3 protein-dependent inhi bition of the regulator of G protein signaling 3 (RGS3) function. (PubMed id 22027839)¹ Rezabkova L....Obsil T. (2011)
35. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
36. Histone deacetylase turnover and recovery in sulforaph ane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SM RT corepressor complex dissociation/reassembly. (PubMed id 21624135)¹ Rajendran P....Dashwood R.H. (2011)
37. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)
38. The phosphatidylinositol transfer protein RdgBI^ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain inter acts with the integral membrane protein ATRAP (angiotensin II type I receptor-a ssociated protein). (PubMed id 21728994)¹ Garner K....Cockcroft S. (2011)
39. Probable participation of 14-3-3 in tau protein oligom erization and aggregation. (PubMed id 21876254)¹ Sluchanko N.N. and Gusev N.B. (2011)
40. NPHP4, a cilia-associated protein, negatively regulat es the Hippo pathway. (PubMed id 21555462)¹ Habbig S....Schermer B. (2011)
41. Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)¹ Jiang W....Zhao S. (2011)
42. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S....Dorf M.E. (2011)
43. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)¹ Neganova I....Lako M. (2011)
44. The phytotoxin fusicoccin promotes platelet aggregati on via 14-3-3-glycoprotein Ib-IX-V interaction. (PubMed id 21395556)¹ Camoni L....Aducci P. (2011)
45. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
46. MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. (PubMed id 21152872)¹ Sun B.K....Song J.J. (2011)
47. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)¹ Lopitz-Otsoa F....Rodriguez M.S. (2011)
48. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
49. A novel Chk1/2-Lats2-14-3-3 signaling pathway regulat es P-body formation in response to UV damage. (PubMed id 21118956)¹ Okada N....Nojima H. (2011)
50. The role of 14-3-3I^ in transcriptional activation of estrogen receptor I+ and its involvement in proliferation of breast cancer cells . (PubMed id 21946067)¹ Kim Y....Ko J. (2011)
51. Neural precursor cell-expressed developmentally down- regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonic al serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. (PubMed id 21900244)¹ Chandran S....Bhalla V. (2011)
52. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
53. Differential expression of 14-3-3 isoforms in human al coholic brain. (PubMed id 21332526)¹ MacKay R.K....Lewohl J.M. (2011)
54. Differential protein expression level identification by knockout of 14-3-3I8 with siRNA technique and 2DE followed MALDI-TOF-TOF-MS. (PubMed id 21046037)¹ Jin H....Yang P.Y. (2011)
55. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)¹ Greco T.M....Cristea I.M. (2011)
56. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
57. Identification and functional characterization of 14- 3-3 in TLR2 signaling. (PubMed id 21827211)¹ Schuster T.B....Ahmad-Nejad P. (2011)
58. An analysis of CAF-1-interacting proteins reveals dyn amic and direct interactions with the KU complex and 14-3-3 proteins. (PubMed id 21209461)¹ Hoek M....Stillman B. (2011)
59. Colocalization of 14-3-3 proteins with SOD1 in Lewy b ody-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model. (PubMed id 21655264)¹ Okamoto Y....Takahashi R. (2011)
60. 14-3-3 binding to LRRK2 is disrupted by multiple Parki nson's disease-associated mutations and regulates cytoplasmic localization. (PubMed id 20642453)¹ Nichols R.J....Alessi D.R. (2010)
61. Dual engagement of 14-3-3 proteins controls signal re lay from ASK2 to the ASK1 signalosome. (PubMed id 19935702)¹ Cockrell L.M....Fu H. (2010)
62. Protein phosphatase 2A reactivates FOXO3a through a d ynamic interplay with 14-3-3 and AKT. (PubMed id 20110348)¹ Singh A....Khosravi-Far R. (2010)
63. 14-3-3 mediated regulation of the tumor suppressor pr otein, RASSF1A. (PubMed id 20069457)¹ Ghazaleh H.A....Baksh S. (2010)
64. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
65. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
66. Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis. (PubMed id 20451386)¹ Douglas M.E....Mishima M. (2010)
67. Impaired binding of 14-3-3 to C-RAF in Noonan syndrom e suggests new approaches in diseases with increased Ras signaling. (PubMed id 20679480)¹ Molzan M....Ottmann C. (2010)
68. Chemosensitivity profiles identify polymorphisms in t he p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survi val. (PubMed id 19996285)¹ Vazquez A....Bond G.L. (2010)
69. Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization. (PubMed id 19933840)¹ Robens J.M....Manser E. (2010)
70. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)¹ Pozuelo-Rubio M. (2010)
71. PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardio myocyte hypertrophy. (PubMed id 20716686)¹ Ha C.H....Jin Z.G. (2010)
72. 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. (PubMed id 20086099)¹ Wang B....Lin W.C. (2010)
73. The PX-RICS-14-3-3zeta/theta complex couples N-cadher in-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum. (PubMed id 20308060)¹ Nakamura T....Akiyama T. (2010)
74. 14-3-3Tau regulates Beclin 1 and is required for auto phagy. (PubMed id 20454448)¹ Wang B....Lin W.C. (2010)
75. The expression of seven 14-3-3 isoforms in human meni ngioma. (PubMed id 20388496)¹ Liu Y....Zhang X. (2010)
76. SLy2 targets the nuclear SAP30/HDAC1 complex. (PubMed id 20478393)¹ Brandt S....Beer-Hammer S. (2010)
77. A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)
78. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (2009)
79. 14-3-3 protein masks the DNA binding interface of for khead transcription factor FOXO4. (PubMed id 19416966)¹ Silhan J....Obsil T. (2009)
80. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)¹ Vega A....Carracedo A. (2009)
81. A 20-amino acid module of protein kinase C{epsilon} i nvolved in translocation and selective targeting at cell-cell contacts. (PubMed id 19429675)¹ Diouf B....Joubert D. (2009)
82. Vpr and its interactions with cellular proteins. (PubMed id 20012529)¹ Planelles V. and Benichou S. (2009)
83. Human immunodeficiency virus type 1 Vpr: functions and molecular interactions. (PubMed id 19458171)¹ Romani B. and Engelbrecht S. (2009)
84. Isoform-specific cleavage of 14-3-3 proteins in apopt otic JURL-MK1 cells. (PubMed id 19173300)¹ KuzelovA! K....Hrkal Z. (2009)
85. Three-way interaction between 14-3-3 proteins, the N- terminal region of tyrosine hydroxylase, and negatively charged membranes. (PubMed id 19801645)¹ Halskau A.9....Martinez A. (2009)
86. Identification of five novel 14-3-3 isoforms interact ing with the GPIb-IX complex in platelets. (PubMed id 19558434)¹ Mangin P.H....Lanza F. (2009)
87. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 m ediates cell cycle and cell death in neurons. (PubMed id 19592491)¹ Jang S.W....Ye K. (2009)
88. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
89. p62 protects SH-SY5Y neuroblastoma cells against H2O2-induced injury through the PDK1/Akt pathway. (PubMed id 19010391)¹ Heo S.R....Joung I. (2009)
90. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)¹ Golebiowski F....Hay R.T. (2009)
91. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
92. The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. (PubMed id 19553522)¹ Lin J....Shaw A.S. (2009)
93. Intracellular traffic of the K+ channels TASK-1 and T ASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 pr oteins. (PubMed id 19139046)¹ Zuzarte M....Preisig-MA1ller R. (2009)
94. Dnmt3/transcription factor interactions as crucial pl ayers in targeted DNA methylation. (PubMed id 19786833)¹ Hervouet E....Cartron P.F. (2009)
95. GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells. (PubMed id 18292392)¹ Pang J....Berk B.C. (2008)
96. The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. (PubMed id 18215133)¹ Fonseca B.D....Proud C.G. (2008)
97. Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera. (PubMed id 18794547)¹ Qiu J....Hanash S.M. (2008)
98. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)¹ Meierhofer D.... Kaiser P. (2008)
99. Human immunodeficiency virus type 1 gp120-mediated dis ruption of tight junction proteins by induction of proteasome-mediated degradati on of zonula occludens-1 and -2 in human brain microvascular endothelial cells. (PubMed id 18569453)¹ Nakamuta S....Kido H. (2008)
100. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
101. Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding. (PubMed id 18550856)¹ Takala H....Fagerholm S.C. (2008)
102. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PubMed id 18779327)¹ Courchet J....Billaud M. (2008)
103. Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. (PubMed id 18249187)¹ Jin Y.H....Lee K.Y. (2008)
104. 14-3-3 regulates the nuclear import of class IIa histone deacetylases. (PubMed id 18952052)¹ Nishino T.G....Yoshida M. (2008)
105. Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. (PubMed id 19011111)¹ Watkins J.L....Piwnica-Worms H. (2008)
106. 14-3-3 proteins recognize a histone code at histone H 3 and are required for transcriptional activation. (PubMed id 18059471)¹ Winter S....Seiser C. (2008)
107. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)
108. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. (PubMed id 17973628)¹ Winge I....Haavik J. (2008)
109. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
110. IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. (PubMed id 18332145)¹ Chen C....White M.A. (2008)
111. Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. (PubMed id 18356162)¹ Lopez-Pajares V....Yuan Z.M. (2008)
112. [Proportion of tau protein to phosphorylated tau protein CSF levels in differential diagnosis of dementia] (PubMed id 18626620)¹ Hort J....Stourac P. (2008)
113. 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr. (PubMed id 18445273)¹ Bolton D.L....Lenardo M.J. (2008)
114. AMPK phosphorylation of raptor mediates a metabolic checkpoint. (PubMed id 18439900)¹ Gwinn D.M....Shaw R.J. (2008)
115. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)¹ Koch H.B....Hermeking H. (2007)
116. Purification and identification of G protein-coupled receptor protein complexes under native conditions. (PubMed id 17215244)¹ Daulat A.M....Jockers R. (2007)
117. Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle. (PubMed id 17369524)¹ Howlett K.F....Hargreaves M. (2007)
118. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. (PubMed id 17617058)¹ Geraghty K.M....MacKintosh C. (2007)
119. An emerin 'proteome': purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)¹ Holaska J.M. and Wilson K.L. (2007)
120. Regulation of Nox1 activity via PKA-mediated phosphorylation of NoxA1 and 14-3-3 binding. (PubMed id 17913709)¹ Kim J.-S.... Bokoch G.M. (2007)
121. Gatekeeper role of 14-3-3tau protein in HIV-1 gp120-mediated apoptosis of human endothelial cells by inactivation of Bad. (PubMed id 17457084)¹ Yano M....Kido H. (2007)
122. Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. (PubMed id 17369396)¹ Parra M....Verdin E. (2007)
123. RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. (PubMed id 17389591)¹ Zhang H....Min W. (2007)
124. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
125. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)¹ Xiao K....Lefkowitz R.J. (2007)
126. Molecular characterization of the HIV type 1 subtype C accessory genes vif, vpr, and vpu. (PubMed id 17331040)¹ Bell C.M....Papathanasopoulos M.A. (2007)
127. 14-3-3 integrates pro-survival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1 transformed hematopoietic cells. (PubMed id 17389761)¹ Dong S.... Chen J. (2007)
128. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)¹ Camargo L.M....Brandon N.J. (2007)
129. Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer. (PubMed id 18089831)¹ Pereira-Faca S.R....Hanash S.M. (2007)
130. New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. (PubMed id 16368544)¹ Calinisan V....Gascard P. (2006)
131. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
132. Structural basis for protein-protein interactions in the 14-3-3 protein family. (PubMed id 17085597)² Yang X.... Elkins J.M. (2006)
133. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)¹ Dequiedt F....Kettmann R. (2006)
134. CPAP interacts with 14-3-3 in a cell cycle-dependent manner. (PubMed id 16516142)¹ Chen C.Y....Tang T.K. (2006)
135. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. (PubMed id 16679322)¹ Pulina M.V....Carafoli E. (2006)
136. Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization. (PubMed id 16367866)¹ Patel A....Connerton I. (2006)
137. Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression. (PubMed id 16581770)¹ Gong W....Riabowol K. (2006)
138. CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s. (PubMed id 16956611)¹ Gao C....Kao H.Y. (2006)
139. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. (PubMed id 16775625)¹ Gao Y.... Chen J. (2006)
140. Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. (PubMed id 16943424)¹ Pereg Y....Jochemsen A.G. (2006)
141. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)² Olsen J.V....Mann M. (2006)
142. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 16888623)¹ Raina D....Kufe D. (2006)
143. The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
144. Detection of CSF 14-3-3 protein in Guillain-Barre syndrome. (PubMed id 17190946)¹ Bersano A....Nobile-Orazio E. (2006)
145. Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members. (PubMed id 16868027)¹ Godde N.J....Novak U. (2006)
146. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. (PubMed id 16511560)¹ LeBron C....Chen J. (2006)
147. Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3. (PubMed id 16176975)¹ Brock C....Pin J.P. (2005)
148. Molecular characterization of ring finger protein 11. (PubMed id 16123141)¹ Connor M.K.... Seth A.K. (2005)
149. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. (PubMed id 15964851)¹ Wang A.H....Yang X.J. (2005)
150. The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein. (PubMed id 16215457)¹ Satoh J....Yamamura T. (2005)
151. Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest. (PubMed id 15708996)¹ Kino T....Pavlakis G.N. (2005)
152. BCR kinase phosphorylates 14-3-3 Tau on residue 233. (PubMed id 16045749)¹ Clokie S.J....Aitken A. (2005)
153. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. (PubMed id 15902271)¹ Pan F....Liu J.O. (2005)
154. Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)¹ Matsumoto M....Nakayama K.I. (2005)
155. Differential targeting of prosurvival Bcl-2 proteins by their BH3- only ligands allows complementary apoptotic function. (PubMed id 15694340)¹ Chen L.... Huang D.C.S. (2005)
156. The cyclin-dependent kinase 11 interacts with 14-3-3 proteins. (PubMed id 15883043)¹ Feng Y....Nelson M.A. (2005)
157. Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes. (PubMed id 15930726)¹ Gurusamy N....Aizawa Y. (2005)
158. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. (PubMed id 15163635)¹ Merla G....Reymond A. (2004)
159. Human follitropin receptor (FSHR) interacts with the adapter protein 14-3-3tau. (PubMed id 15196694)¹ Cohen B.D....Dias J.A. (2004)
160. Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. (PubMed id 14597563)¹ Fuller W....Shattock M.J. (2004)
161. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)¹ Screaton R.A.... Montminy M. (2004)
162. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)¹ Jin J....Pawson T. (2004)
163. Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? (PubMed id 15265780)¹ Kino T. and Chrousos G.P. (2004)
164. Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils. (PubMed id 15094368)¹ Melander F....Dib K. (2004)
165. p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. (PubMed id 14970201)¹ Zenke F.T....Bokoch G.M. (2004)
166. Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells. (PubMed id 15280438)¹ Watabe M. and Nakaki T. (2004)
167. Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins. (PubMed id 15023544)¹ Subramanian R.R....Fu H. (2004)
168. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
169. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)¹ Bouwmeester T....Superti-Furga G. (2004)
170. Comprehensive proteomic analysis of interphase and mi totic 14-3-3-binding proteins. (PubMed id 15161933)¹ Meek S.E....Piwnica-Worms H. (2004)
171. A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. (PubMed id 15494392)¹ Wang B....Lin W.C. (2004)
172. Cyclin-dependent kinase 11p110 and casein kinase 2 (CK2) inhibit the interaction between tyrosine hydroxylase and 14-3-3. (PubMed id 14675149)¹ Sachs N.A. and Vaillancourt R.R. (2004)
173. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)¹ Colland F....Gauthier J.M. (2004)
174. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. (PubMed id 15367659)¹ Vega R.B....McKinsey T.A. (2004)
175. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. (PubMed id 12911633)¹ Henshall D.C....Simon R.P. (2003)
176. 14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. (PubMed id 12853467)¹ Pozuelo Rubio M....MacKintosh C. (2003)
177. The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. (PubMed id 12919677)¹ Santoro M.M....Marchisio P.C. (2003)
178. Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437. (PubMed id 12816952)¹ Rishi A.K....Reichert U. (2003)
179. The chaperone protein 14-3-3 interacts with 3BP2/SH3BP2 and regulates its adapter function. (PubMed id 12501243)¹ Foucault I....Deckert M. (2003)
180. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. (PubMed id 12535517)¹ Basu S....Downward J. (2003)
181. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)¹ Muller J....Morrison D.K. (2003)
182. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)¹ Tchernev V.T....Kingsmore S.F. (2002)
183. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). (PubMed id 12438239)¹ Liu M.Y....Walker C.L. (2002)
184. The mouse interferon-inducible gene Ifi204 product in teracts with the Tpr protein, a component of the nuclear pore complex. (PubMed id 12513910)¹ De Andrea M....Landolfo S. (2002)

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