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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAQ Gene

protein-coding   GIFtS: 70
GCID: GC02M009724

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Theta Polypeptide1 2
     14-3-3 Protein Theta2
14-3-3 Protein T-Cell2 3     1C52
14-3-3 Protein Tau2 3     HS12
Protein Tau1     Protein HS13
14-3-32     

External Ids:    HGNC: 128541   Entrez Gene: 109712   Ensembl: ENSG000001343087   OMIM: 6090095   UniProtKB: P273483   

Export aliases for YWHAQ gene to outside databases

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745 GC02M009674 GC02M009641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAQ Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with
amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic,
however, there is no correlation between the repeat number and the disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for YWHAQ Gene: 
YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide) is a protein-coding gene. Diseases associated with YWHAQ include lateral sclerosis, and amyotrophic lateral sclerosis, and among its related super-pathways are Cell cycle and Cell cycle Role of 14-3-3 proteins in cell cycle regulation. GO annotations related to this gene include protein N-terminus binding and protein domain specific binding. An important paralog of this gene is YWHAH.

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAQ Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAQ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAQ gene promoter:
         GR   GR-beta   MyoD   NF-kappaB   CREB   deltaCREB   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAQ promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25.2-p25.1

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAQ gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M009724:  view genomic region     (about GC identifiers)

Start:
9,724,101 bp from pter      End:
9,771,143 bp from pter
Size:
47,043 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348 (See protein sequence)
Recommended Name: 14-3-3 protein theta  
Size: 245 amino acids; 27764 Da
Subunit: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198'
phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with
the 'Ser-241' phosphorylated form of PDPK1
Subcellular location: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals
1 PDB 3D structure from and Proteopedia for YWHAQ:
2BTP (3D)    
Secondary accessions: D6W4Z5 Q567U5 Q5TZU8 Q9UP48

Explore the universe of human proteins at neXtProt for YWHAQ: NX_P27348

Explore proteomics data for YWHAQ at MOPED 

Post-translational modifications:

  • UniProtKB: Ser-232 is probably phosphorylated by CK1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27348

  • YWHAQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YWHAQ Protein Expression
    REFSEQ proteins: NP_006817.1  
    ENSEMBL proteins: 
     ENSP00000371267   ENSP00000238081   ENSP00000398990  
    Reactome Protein details: P27348
    Human Recombinant Protein Products for YWHAQ: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for YWHAQ
    OriGene Purified Protein for YWHAQ
    OriGene Protein Over-expression Lysate for YWHAQ
    OriGene MassSpec for YWHAQ 
    OriGene Custom Protein Services for YWHAQ
    GenScript Custom Purified and Recombinant Proteins Services for YWHAQ
    Novus Biologicals YWHAQ Proteins
    Novus Biologicals YWHAQ Lysate
    Sino Biological Recombinant Protein for YWHAQ
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for YWHAQ
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15163635
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane TAS--
    GO:0043234protein complex ----
    GO:0070062extracellular vesicular exosome IDA--

    YWHAQ for ontologies           About GeneDecksing



    YWHAQ Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAQ
    R&D Systems Antibodies for YWHAQ (14-3-3 theta)
    Cell Signaling Technology (CST) Antibodies for YWHAQ  (14-3-3 theta)
    OriGene Antibodies for YWHAQ
    OriGene Custom Antibody Services for YWHAQ
    GenScript Custom Superior Antibodies Services for YWHAQ
    Novus Biologicals YWHAQ Antibodies
    Abcam antibodies for YWHAQ
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for YWHAQ
    LSBio Antibodies in human, mouse, rat for YWHAQ 

    Assay Products for YWHAQ: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YWHAQ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YWHAQ
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry P27348

    ProtoNet protein and cluster: P27348

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Similarity: Belongs to the 14-3-3 family


    YWHAQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433T_HUMAN, P27348
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAQ:
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide stratifin,with likely
    several forms,one expressed in the cytoplasmic of keratinocyte,another in T cells,multifunctional regulator
    involved in cell-cyle control (checkpoint) and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10954706
    GO:0019904protein domain specific binding IEA--
    GO:0047485protein N-terminus binding IPI11984006
    GO:007188914-3-3 protein binding ----
         
    YWHAQ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for YWHAQ:
     Decreased telomerase activity 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ywhaq):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  muscle 

    YWHAQ for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YWHAQ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for YWHAQ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAQ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAQ 

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAQ:
    hsa-mir-1 (MIRT001321)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAQ
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAQ (see all 45):
    hsa-miR-582-3p hsa-miR-429 hsa-miR-548k hsa-miR-15a hsa-miR-139-5p hsa-miR-374c hsa-miR-3122 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidYWHAQ 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for YWHAQ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAQ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YWHAQ
    Sirion Biotech Customized adenovirus for overexpression of YWHAQ

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for YWHAQ (see all 9)
    OriGene ORF clones in mouse, rat for YWHAQ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YWHAQ (NM_006826)
    Sino Biological Human cDNA Clone for YWHAQ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAQ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAQ
    Sirion Biotech Customized lentivirus for stable overexpression of YWHAQ 
                         Customized lentivirus expression plasmids for stable overexpression of YWHAQ 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for YWHAQ
    Search LifeMap BioReagents cell lines for YWHAQ
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAQ


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for YWHAQ About   (see all 50)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Slit-Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    4Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for YWHAQ
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAQ
        Apoptosis Signaling Pathways

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAQ (see all 19)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    4 Cell Signaling Technology (CST) Pathways for YWHAQ
        MAP Kinase Signaling
    Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAQ
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAQ
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/19 BioSystems Pathways for YWHAQ (see all 19)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    Alpha6-Beta4 Integrin Signaling Pathway


    5/6        Reactome Pathways for YWHAQ (see all 6)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    5/8         Kegg Pathways  (Kegg details for YWHAQ) (see all 8):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Pathogenic Escherichia coli infection


    YWHAQ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    317/628 Interacting proteins for YWHAQ (P273481, 2, 3 ENSP000002380814) via UniProtKB, MINT, STRING, and/or I2D (see all 628) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000352980
    HIST2H4AP628052, 3, ENSP000003581624MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000358162
    HIST1H4BP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4EP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4FP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4HP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4IP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4JP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4KP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST1H4LP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST2H4BP628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HIST4H4P628052, 3MINT-7899812 MINT-7900157 I2D: score=2 
    HSPA1AP081072, 3, ENSP000003648024MINT-50363 I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081072, 3MINT-50363 I2D: score=3 
    ENSG00000215328P081072, 3MINT-50363 I2D: score=3 
    ENSG00000224501P081072, 3MINT-50363 I2D: score=3 
    ENSG00000231555P081072, 3MINT-50363 I2D: score=3 
    ENSG00000234475P081072, 3MINT-50363 I2D: score=3 
    ENSG00000235941P081072, 3MINT-50363 I2D: score=3 
    ENSG00000237724P081072, 3MINT-50363 I2D: score=3 
    HSPA1BP081072, 3MINT-50363 I2D: score=3 
    ENSG00000232575P074372, 3, ENSP000004100714MINT-8415355 I2D: score=2 STRING: ENSP00000410071
    SH3BP2P783142, 3, ENSP000003486854MINT-18071 MINT-17096 MINT-18073 MINT-17095 MINT-17097 MINT-18070 MINT-8006273 MINT-8006280 I2D: score=2 STRING: ENSP00000348685
    CBLP226812, 3, ENSP000002640334MINT-8005960 MINT-8006676 MINT-8005073 MINT-8005080 MINT-8005974 MINT-8005094 MINT-7899812 MINT-8005885 MINT-8005953 MINT-8005087 MINT-8005023 MINT-8005967 I2D: score=4 STRING: ENSP00000264033
    ENSG00000232804P081072, 3, ENSP000003930874MINT-50363 I2D: score=3 STRING: ENSP00000393087
    KANK1Q146781, 2, 3, ENSP000003717344EBI-359854,EBI-2556221 MINT-8008416 I2D: score=1 STRING: ENSP00000371734
    CDKN1BP465272, 3, ENSP000002288724MINT-8006094 MINT-17888 MINT-8008250 MINT-8008504 MINT-17889 MINT-8007803 MINT-8008511 I2D: score=5 STRING: ENSP00000228872
    ENSG00000183311P074372, 3MINT-8415355 I2D: score=2 
    ENSG00000224156P074372, 3MINT-8415355 I2D: score=2 
    ENSG00000227739P074372, 3MINT-8415355 I2D: score=2 
    ENSG00000229684P074372, 3MINT-8415355 I2D: score=2 
    ENSG00000232421P074372, 3MINT-8415355 I2D: score=2 
    ENSG00000235067P074372, 3MINT-8415355 I2D: score=2 
    TUBBP074372, 3MINT-8415355 I2D: score=2 
    YWHAEP622582, 3, ENSP000002643354MINT-7300139 MINT-7899812 MINT-7900157 MINT-8395092 I2D: score=4 STRING: ENSP00000264335
    HIST1H2AGP0C0S82, 3MINT-7899812 I2D: score=1 
    HIST1H2AIP0C0S82, 3MINT-7899812 I2D: score=1 
    HIST1H2ALP0C0S82, 3MINT-7899812 I2D: score=1 
    HIST1H2AMP0C0S82, 3MINT-7899812 I2D: score=1 
    PDPK1O155302, 3, ENSP000003442204MINT-16332 MINT-16331 MINT-16333 I2D: score=4 STRING: ENSP00000344220
    YWHAHQ049172, 3, ENSP000002489754MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000248975
    YWHABP319462, 3, ENSP000003001614MINT-7300139 MINT-7264099 MINT-7900157 I2D: score=2 STRING: ENSP00000300161
    TSC2P498152, 3, ENSP000002194764MINT-7899812 MINT-14051 I2D: score=7 STRING: ENSP00000219476
    TUBA3CQ137482, 3, ENSP000003829824MINT-50364 I2D: score=4 STRING: ENSP00000382982
    TUBA3DQ137482, 3, ENSP000003260424MINT-50364 I2D: score=4 STRING: ENSP00000326042
    YAP1P469372, 3, ENSP000002824414MINT-18935 MINT-8006305 I2D: score=3 STRING: ENSP00000282441
    ACTA2P627362, 3, ENSP000002247844MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000224784
    ACTBP607092, 3, ENSP000003499604MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000349960
    ANKRD18AQ8IVF62, 3, ENSP000003826104MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000382610
    CALM2P621582, 3MINT-7899812 I2D: score=1 
    CALM3P621582, 3MINT-7899812 I2D: score=1 
    KRT17Q046952, 3, ENSP000003084524MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000308452
    KRT8P057872, 3, ENSP000002933084MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000293308
    MEFVO155532, 3, ENSP000002195964MINT-8007132 MINT-8007125 I2D: score=1 STRING: ENSP00000219596
    MYH13Q9UKX32, 3, ENSP000002521724MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000252172
    MYL3P085902, 3, ENSP000002923274MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000292327
    CABIN1Q9Y6J02, 3, ENSP000002631194MINT-8007070 I2D: score=5 STRING: ENSP00000263119
    MAGOHP613262, 3, ENSP000003605254MINT-50369 I2D: score=5 STRING: ENSP00000360525
    EIF4A3P389192, 3, ENSP000002693494MINT-50375 I2D: score=4 STRING: ENSP00000269349
    ING1Q9UK532, 3, ENSP000003649294MINT-8007452 I2D: score=4 STRING: ENSP00000364929
    KLC2Q9H0B62, 3, ENSP000003148374MINT-50360 I2D: score=4 STRING: ENSP00000314837
    KRT1P042642, 3, ENSP000002522444MINT-51001 I2D: score=4 STRING: ENSP00000252244
    KRT9P355272, 3, ENSP000002466624MINT-50365 I2D: score=4 STRING: ENSP00000246662
    MAP3K3Q997592, 3MINT-47989 MINT-48421 I2D: score=4 
    RAI14Q9P0K72, 3, ENSP000002651094MINT-51002 I2D: score=4 STRING: ENSP00000265109
    CDK14O949211, 3, ENSP000002657414EBI-359854,EBI-1043945 I2D: score=3 STRING: ENSP00000265741
    CDC25AP303042, 3, ENSP000003037064MINT-8008839 I2D: score=2 STRING: ENSP00000303706
    HDAC4P565242, 3, ENSP000002646064MINT-8008106 I2D: score=2 STRING: ENSP00000264606
    MDM2Q009872, 3, ENSP000004172814MINT-8415355 I2D: score=2 STRING: ENSP00000417281
    MDM4O151512, 3, ENSP000003561504MINT-8007350 I2D: score=2 STRING: ENSP00000356150
    MST1RQ049122, 3, ENSP000002964744MINT-8006465 I2D: score=2 STRING: ENSP00000296474
    TCP1P179872, 3, ENSP000003173344MINT-8415355 I2D: score=2 STRING: ENSP00000317334
    ACTG1P632612, 3, ENSP000003315144MINT-7899812 I2D: score=1 STRING: ENSP00000331514
    ATP5BP065762, 3, ENSP000002620304MINT-7900157 I2D: score=1 STRING: ENSP00000262030
    COPS4Q9BT782, 3, ENSP000002643894MINT-8415355 I2D: score=1 STRING: ENSP00000264389
    CPS1P313272, 3, ENSP000004026084MINT-7900157 I2D: score=1 STRING: ENSP00000402608
    DESP176612, 3, ENSP000003630714MINT-7899812 I2D: score=1 STRING: ENSP00000363071
    DHX9Q082112, 3, ENSP000003565204MINT-8395092 I2D: score=1 STRING: ENSP00000356520
    EEF1A1P681042, 3, ENSP000003300544MINT-7900157 I2D: score=1 STRING: ENSP00000330054
    ELAVL1Q157172, 3, ENSP000003852694MINT-8008488 I2D: score=1 STRING: ENSP00000385269
    H2AFXP161042, 3, ENSP000003643104MINT-7899812 I2D: score=1 STRING: ENSP00000364310
    HADHAP409392, 3, ENSP000003700234MINT-8395092 I2D: score=1 STRING: ENSP00000370023
    HMGCS2P548682, 3, ENSP000003584144MINT-7900157 I2D: score=1 STRING: ENSP00000358414
    MAPTP106362, 3, ENSP000003408204MINT-8006880 I2D: score=1 STRING: ENSP00000340820
    MYCBP2O755922, 3, ENSP000003498924MINT-8395092 I2D: score=1 STRING: ENSP00000349892
    MYH11P357492, 3, ENSP000003796164MINT-7899812 I2D: score=1 STRING: ENSP00000379616
    MYH2Q9UKX22, 3, ENSP000002455034MINT-7899812 I2D: score=1 STRING: ENSP00000245503
    NPM1P067482, 3, ENSP000002969304MINT-7899812 I2D: score=1 STRING: ENSP00000296930
    PRKDCP785272, 3, ENSP000003134204MINT-7900157 I2D: score=1 STRING: ENSP00000313420
    RPS3P233962, 3, ENSP000002785724MINT-7899812 I2D: score=1 STRING: ENSP00000278572
    SSBP1Q048372, 3, ENSP000002653044MINT-8395092 I2D: score=1 STRING: ENSP00000265304
    SSH1Q8WYL52, 3, ENSP000003157134MINT-8008916 I2D: score=1 STRING: ENSP00000315713
    TGIF2LYQ8IUE02, 3, ENSP000003185024MINT-7899812 I2D: score=1 STRING: ENSP00000318502
    TUBA1CQ9BQE32, 3, ENSP000003010724MINT-7900157 I2D: score=1 STRING: ENSP00000301072
    TUT1Q9H6E52, 3, ENSP000002782794MINT-7900157 I2D: score=1 STRING: ENSP00000278279
    USP42Q9H9J42, 3, ENSP000003019624MINT-7899812 I2D: score=1 STRING: ENSP00000301962
    WNK4Q96J922, 3, ENSP000002469144MINT-7900157 I2D: score=1 STRING: ENSP00000246914
    LARP1Q6PKG02, 3MINT-51000 I2D: score=4 
    SMAD9O151982, 3MINT-62137 I2D: score=3 
    ARRB1P494071, 3EBI-359854,EBI-743313 I2D: score=1 
    ARRB2P321211, 3EBI-359854,EBI-714559 I2D: score=1 
    CCT4P509912, 3MINT-8415355 I2D: score=1 
    CCT8P509902, 3MINT-8415355 I2D: score=1 
    CEP250Q9BV732, 3MINT-7899812 I2D: score=1 
    ILF2Q129052, 3MINT-8395092 I2D: score=1 
    IQGAP1P469402, 3MINT-8395092 I2D: score=1 
    MRPS27Q925522, 3MINT-8395092 I2D: score=1 
    TTNQ8WZ422, 3MINT-7899812 I2D: score=1 
    YWHAZP631042, 3, ENSP000003095034MINT-7300139 MINT-8415355 MINT-7264099 MINT-7899812 MINT-7900157 I2D: score=2 STRING: ENSP00000309503
    HIST1H2AKP0C0S82, 3, ENSP000003303074MINT-7899812 I2D: score=1 STRING: ENSP00000330307
    YWHAGP619812, 3, ENSP000003063304MINT-7300139 MINT-8415355 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000306330
    HIST1H2BCP628073I2D: score=2 
    HIST1H2BEP628073I2D: score=2 
    HIST1H2BFP628073I2D: score=2 
    HIST1H2BGP628073I2D: score=2 
    HIST1H2BIP628073I2D: score=2 
    RAF1P040492, 3, ENSP000002518494MINT-8005892 MINT-8005941 MINT-8004880 I2D: score=4 STRING: ENSP00000251849
    FSHRP239451, 2, 3, ENSP000003847084EBI-359854,EBI-848239 MINT-8009599 MINT-8010010 I2D: score=3 STRING: ENSP00000384708
    CALM1P621582, 3, ENSP000003494674MINT-7899812 I2D: score=1 STRING: ENSP00000349467
    SFNP319472, 3, ENSP000003409894MINT-7300139 MINT-7264099 MINT-7900157 I2D: score=2 STRING: ENSP00000340989
    PI4KBQ9UBF82, 3, ENSP000002716574MINT-8007601 MINT-50361 I2D: score=5 STRING: ENSP00000271657
    HIST2H3CQ71DI33, ENSP000003581544I2D: score=1 STRING: ENSP00000358154
    PIK3CBP423382, 3, ENSP000002891534MINT-16257 MINT-16256 I2D: score=3 STRING: ENSP00000289153
    NFATC4Q149342, 3, ENSP000003889104MINT-8005440 MINT-8005433 I2D: score=3 STRING: ENSP00000388910
    EGFRP005331, 2, 3, ENSP000002754934EBI-359854,EBI-297353 MINT-7300139 I2D: score=2 STRING: ENSP00000275493
    ATP5A1P257052, 3, ENSP000002820504MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000282050
    H1F0P073052, 3, ENSP000003445044MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000344504
    MYH7P128832, 3, ENSP000003475074MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000347507
    MYH9P355792, 3, ENSP000002161814MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000216181
    MYLK2Q9H1R32, 3, ENSP000003651524MINT-7899812 MINT-7900157 I2D: score=1 STRING: ENSP00000365152
    TUBB2AQ138852, 3, ENSP000003697034MINT-8415355 MINT-7899812 I2D: score=1 STRING: ENSP00000369703
    ENSG00000096171P266403I2D: score=1 
    ENSG00000226589P266403I2D: score=1 
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    VARSP266403I2D: score=1 
    BRAFP150562, 3, ENSP000002886024MINT-50372 I2D: score=4 STRING: ENSP00000288602
    KRT18P057832, 3, ENSP000003734874MINT-7899812 I2D: score=2 STRING: ENSP00000373487
    RGS3P497962, 3, ENSP000002594064MINT-8007221 I2D: score=3 STRING: ENSP00000259406
    MEF2DQ148142, 3, ENSP000002715554MINT-8005675 I2D: score=4 STRING: ENSP00000271555
    GP1BAP073592, 3, ENSP000003293804MINT-8009070 I2D: score=1 STRING: ENSP00000329380
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2868973 I2D: score=3 STRING: ENSP00000357292
    MPRIPQ6WCQ12, 3, ENSP000003791564MINT-51003 I2D: score=3 STRING: ENSP00000379156
    HNRNPCP079102, 3, ENSP000003196904MINT-7899812 I2D: score=1 STRING: ENSP00000319690
    LMNAP025452, 3, ENSP000003572834MINT-7899812 I2D: score=1 STRING: ENSP00000357283
    VIMP086702, 3, ENSP000002242374MINT-7899812 I2D: score=2 STRING: ENSP00000224237
    USP8P408182, 3, ENSP000003022394MINT-50371 I2D: score=5 STRING: ENSP00000302239
    ACTN2P356092, 3, ENSP000003555374MINT-7899812 I2D: score=1 STRING: ENSP00000355537
    BANK1Q8NDB22, 3, ENSP000003205094MINT-7899812 I2D: score=1 STRING: ENSP00000320509
    CACNA1SQ136982, 3, ENSP000003551924MINT-7899812 I2D: score=1 STRING: ENSP00000355192
    HIST1H1CP164032, 3, ENSP000003395664MINT-7899812 I2D: score=2 STRING: ENSP00000339566
    HIST1H1DP164022, 3, ENSP000002445344MINT-7899812 I2D: score=1 STRING: ENSP00000244534
    HIST1H1TP224922, 3, ENSP000003412144MINT-7899812 I2D: score=1 STRING: ENSP00000341214
    HIST1H2BDP588762, ENSP000002893164MINT-7899812 MINT-7900157 STRING: ENSP00000289316
    HNRNPA2B1P226262, 3, ENSP000003466944MINT-7899812 I2D: score=1 STRING: ENSP00000346694
    HSPB1P047922, 3, ENSP000002485534MINT-7900157 I2D: score=1 STRING: ENSP00000248553
    RALYQ9UKM92, 3, ENSP000002461944MINT-7899812 I2D: score=1 STRING: ENSP00000246194
    TPM1P094932, 3, ENSP000002679964MINT-7899812 I2D: score=1 STRING: ENSP00000267996
    VASPP505522, 3, ENSP000002459324MINT-7899812 I2D: score=1 STRING: ENSP00000245932
    KIF5BP331762, 3, ENSP000003070784MINT-50370 I2D: score=5 STRING: ENSP00000307078
    HSPA8P111422, 3, ENSP000002273784MINT-50373 I2D: score=5 STRING: ENSP00000227378
    PRMT5O147442, 3, ENSP000003191694MINT-50374 I2D: score=2 STRING: ENSP00000319169
    WDR77Q9BQA12, 3, ENSP000002350904MINT-50362 I2D: score=3 STRING: ENSP00000235090
    C7orf55-LUC7L2Q9Y3833, ENSP000003470054I2D: score=2 STRING: ENSP00000347005
    HNRNPA1P096512, 3, ENSP000003418264MINT-8395092 I2D: score=1 STRING: ENSP00000341826
    TRIM28Q132632, 3, ENSP000002530244MINT-8395092 I2D: score=1 STRING: ENSP00000253024
    BADQ929343, ENSP000003091034I2D: score=5 STRING: ENSP00000309103
    APCP250543, ENSP000002574304I2D: score=4 STRING: ENSP00000257430
    MAP3K5Q996833, ENSP000003519084I2D: score=4 STRING: ENSP00000351908
    UCP2P558513, ENSP000003120294I2D: score=4 STRING: ENSP00000312029
    UCP3P559163, ENSP000003237404I2D: score=4 STRING: ENSP00000323740
    EPB41L3Q9Y2J23, ENSP000003411384I2D: score=3 STRING: ENSP00000341138
    HAX1O001653, ENSP000003290024I2D: score=3 STRING: ENSP00000329002
    REM1O756283, ENSP000002019794I2D: score=3 STRING: ENSP00000201979
    SH3BP4Q9P0V33, ENSP000003402374I2D: score=3 STRING: ENSP00000340237
    TSC1Q925743, ENSP000002985524I2D: score=3 STRING: ENSP00000298552
    CALML5Q9NZT13, ENSP000003696894I2D: score=2 STRING: ENSP00000369689
    CAPN3P208073, ENSP000003803494I2D: score=2 STRING: ENSP00000380349
    CDC25BP303053, ENSP000002459604I2D: score=2 STRING: ENSP00000245960
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    EDC3Q96F863, ENSP000003205034I2D: score=2 STRING: ENSP00000320503
    EML3Q32P443, ENSP000003782544I2D: score=2 STRING: ENSP00000378254
    EPB41L2O434913, ENSP000003384814I2D: score=2 STRING: ENSP00000338481
    FGRP097693, ENSP000003631154I2D: score=2 STRING: ENSP00000363115
    KIAA0930Q6ICG63, ENSP000002519934I2D: score=2 STRING: ENSP00000251993
    KIF23Q022413, ENSP000002603634I2D: score=2 STRING: ENSP00000260363
    KIF5CO602823, ENSP000003933794I2D: score=2 STRING: ENSP00000393379
    LUC7L2Q9Y3833I2D: score=2 
    MTNR1BP492863, ENSP000002570684I2D: score=2 STRING: ENSP00000257068
    NIF3L1Q9GZT83, ENSP000003863944I2D: score=2 STRING: ENSP00000386394
    PAK6Q9NQU53, ENSP000002604044I2D: score=2 STRING: ENSP00000260404
    PRKD1Q151393, ENSP000003335684I2D: score=2 STRING: ENSP00000333568
    RASGRP3Q8IV613, ENSP000003841924I2D: score=2 STRING: ENSP00000384192
    SPIRE1Q08AE83, ENSP000003872664I2D: score=2 STRING: ENSP00000387266
    SRSF10O754943, ENSP000004201954I2D: score=2 STRING: ENSP00000420195
    TERTO147463, ENSP000003095724I2D: score=2 STRING: ENSP00000309572
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    ACSL4O604883, ENSP000003397874I2D: score=1 STRING: ENSP00000339787
    ANXA1P040833, ENSP000002574974I2D: score=1 STRING: ENSP00000257497
    ANXA2P073553, ENSP000003460324I2D: score=1 STRING: ENSP00000346032
    ARHGAP10A1A4S63, ENSP000003369234STRING: ENSP00000336923 I2D: score=1 
    ARHGEF16Q5VV413, ENSP000003676294I2D: score=1 STRING: ENSP00000367629
    ARHGEF2Q929743, ENSP000003153254I2D: score=1 STRING: ENSP00000315325
    BCAP31P515723, ENSP000003923304I2D: score=1 STRING: ENSP00000392330
    CDK16Q005363, ENSP000004057984I2D: score=1 STRING: ENSP00000405798
    CDK17Q005373, ENSP000002612114I2D: score=1 STRING: ENSP00000261211
    CDKN1AP389363, ENSP000002447414I2D: score=1 STRING: ENSP00000244741
    CFL1P235283, ENSP000003096294I2D: score=1 STRING: ENSP00000309629
    CHAF1AQ131113, ENSP000003012804I2D: score=1 STRING: ENSP00000301280
    CKMP067323, ENSP000002214764I2D: score=1 STRING: ENSP00000221476
    CSNK2A1P684003, ENSP000002172444I2D: score=1 STRING: ENSP00000217244
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    DCPSQ96C863, ENSP000002635794I2D: score=1 STRING: ENSP00000263579
    DDX1Q924993, ENSP000002330844I2D: score=1 STRING: ENSP00000233084
    E2F1Q010943, ENSP000003455714I2D: score=1 STRING: ENSP00000345571
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    FASNP493273, ENSP000003045924I2D: score=1 STRING: ENSP00000304592
    FOXO3O435243, ENSP000003395274I2D: score=1 STRING: ENSP00000339527
    FSCN1Q166583, ENSP000003717984I2D: score=1 STRING: ENSP00000371798
    GCN1L1Q926163, ENSP000003006484I2D: score=1 STRING: ENSP00000300648
    HAT1O149293, ENSP000002641084I2D: score=1 STRING: ENSP00000264108
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    HNRNPH1P319433, ENSP000003491684I2D: score=1 STRING: ENSP00000349168
    HNRNPKP619783, ENSP000003654394I2D: score=1 STRING: ENSP00000365439
    IARS2Q9NSE43, ENSP000003032794I2D: score=1 STRING: ENSP00000303279
    ITGB4P161443, ENSP000002001814I2D: score=1 STRING: ENSP00000200181
    KLC3Q6P5973, ENSP000003758104I2D: score=1 STRING: ENSP00000375810
    LARS2Q150313, ENSP000002655374I2D: score=1 STRING: ENSP00000265537
    LDHAP003383, ENSP000003953374I2D: score=1 STRING: ENSP00000395337
    LEPREL4Q927913, ENSP000003476494I2D: score=1 STRING: ENSP00000347649
    LIMA1Q9UHB63, ENSP000003784004I2D: score=1 STRING: ENSP00000378400
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MCM3P252053, ENSP000002298544I2D: score=1 STRING: ENSP00000229854
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    NADKO955443, ENSP000003416794I2D: score=1 STRING: ENSP00000341679
    NCLP193383, ENSP000003181954I2D: score=1 STRING: ENSP00000318195
    NFATC1O956443, ENSP000003278504I2D: score=1 STRING: ENSP00000327850
    NME7Q9Y5B83, ENSP000003567854I2D: score=1 STRING: ENSP00000356785
    NOLC1Q149783, ENSP000003590244I2D: score=1 STRING: ENSP00000359024
    PABPC4Q133103, ENSP000003619494I2D: score=1 STRING: ENSP00000361949
    PANK1Q8TE043, ENSP000003021084I2D: score=1 STRING: ENSP00000302108
    PDE3AQ144323, ENSP000003519574I2D: score=1 STRING: ENSP00000351957
    PDK1Q151183, ENSP000002820774I2D: score=1 STRING: ENSP00000282077
    PFN1P077373, ENSP000002256554I2D: score=1 STRING: ENSP00000225655
    PHLDB2Q86SQ03, ENSP000003775024I2D: score=1 STRING: ENSP00000377502
    PIK3C2BO007503, ENSP000003561554I2D: score=1 STRING: ENSP00000356155
    PKMP146183, ENSP000003201714I2D: score=1 STRING: ENSP00000320171
    PRDX1Q068303, ENSP000002627464I2D: score=1 STRING: ENSP00000262746
    PTPN3P260453, ENSP000002625394I2D: score=1 STRING: ENSP00000262539
    RFC1P352513, ENSP000002614244I2D: score=1 STRING: ENSP00000261424
    RGS7P498023, ENSP000003555204I2D: score=1 STRING: ENSP00000355520
    RNASE2P101533, ENSP000003032764I2D: score=1 STRING: ENSP00000303276
    RPL21P467783, ENSP000003460274I2D: score=1 STRING: ENSP00000346027
    RPLP0P053883, ENSP000003390274I2D: score=1 STRING: ENSP00000339027
    RPLP2P053873, ENSP000003224194I2D: score=1 STRING: ENSP00000322419
    RPTORQ8N1223, ENSP000003072724I2D: score=1 STRING: ENSP00000307272
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    SAMSN1Q9NSI83, ENSP000003834114I2D: score=1 STRING: ENSP00000383411
    SLC8A2Q9UPR53, ENSP000002368774I2D: score=1 STRING: ENSP00000236877
    SLC8A3P571033, ENSP000003706694I2D: score=1 STRING: ENSP00000370669
    SNRPEP623043, ENSP000004005914I2D: score=1 STRING: ENSP00000400591
    SPTBP112773, ENSP000003743724I2D: score=1 STRING: ENSP00000374372
    THRAP108273, ENSP000002646374I2D: score=1 STRING: ENSP00000264637
    TLN1Q9Y4903, ENSP000003160294I2D: score=1 STRING: ENSP00000316029
    TP53BP2Q136253, ENSP000003419574I2D: score=1 STRING: ENSP00000341957
    WDR61Q9GZS33, ENSP000002679734I2D: score=1 STRING: ENSP00000267973
    WWC2Q6AWC23, ENSP000003842224I2D: score=1 STRING: ENSP00000384222
    HDAC7Q8WUI43, ENSP000000800594I2D: score=2 STRING: ENSP00000080059
    SLC2A4P146723, ENSP000003209354I2D: score=1 STRING: ENSP00000320935
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CRTC2Q53ET03, ENSP000003058734I2D: score=1 STRING: ENSP00000305873
    MTORP423453, ENSP000003545584I2D: score=5 STRING: ENSP00000354558
    BAXQ078123, ENSP000002932884I2D: score=3 STRING: ENSP00000293288
    CCAR1Q8IX123, ENSP000002658724I2D: score=1 STRING: ENSP00000265872
    CDC25CP303073, ENSP000003216564I2D: score=1 STRING: ENSP00000321656
    CSNK1A1P487293, ENSP000002617984I2D: score=2 STRING: ENSP00000261798
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    EPB41L1Q9H4G03, ENSP000003371684I2D: score=1 STRING: ENSP00000337168
    PFKFB2O608253, ENSP000003560474I2D: score=3 STRING: ENSP00000356047
    NFATC2Q134693, ENSP000003793304I2D: score=1 STRING: ENSP00000379330
    BCRP112743, ENSP000003035074I2D: score=2 STRING: ENSP00000303507
    CAMK2AQ9UQM73, ENSP000003814124I2D: score=1 STRING: ENSP00000381412
    DAPK1P533553, ENSP000003507854I2D: score=1 STRING: ENSP00000350785
    FXYD1O001683, ENSP000003433144I2D: score=1 STRING: ENSP00000343314
    PRKCZQ055133, ENSP000003678304I2D: score=1 STRING: ENSP00000367830
    SLC8A1P324183, ENSP000003329314I2D: score=1 STRING: ENSP00000332931
    LYSTQ996983, ENSP000003744434I2D: score=3 STRING: ENSP00000374443
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    NCOA1Q157883, ENSP000003209404I2D: score=1 STRING: ENSP00000320940
    NCOA3Q9Y6Q93, ENSP000003610664I2D: score=1 STRING: ENSP00000361066
    NRIP1P485523, ENSP000003272134I2D: score=1 STRING: ENSP00000327213
    KCNK3O146493, ENSP000003062754I2D: score=1 STRING: ENSP00000306275
    KCNK9Q9NPC23, ENSP000003021664I2D: score=1 STRING: ENSP00000302166
    OPTNQ96CV93, ENSP000002630364I2D: score=1 STRING: ENSP00000263036
    MYL12BO149503, ENSP000002375004I2D: score=1 STRING: ENSP00000237500
    SAMD4BQ5PRF93, ENSP000003172244I2D: score=2 STRING: ENSP00000317224
    SRSF3P841033, ENSP000003628204I2D: score=4 STRING: ENSP00000362820
    CDC5LQ994593, ENSP000003605324I2D: score=1 STRING: ENSP00000360532
    MARK2Q7KZI73, ENSP000003891844I2D: score=1 STRING: ENSP00000389184
    IRS2Q9Y4H23, ENSP000003650164I2D: score=2 STRING: ENSP00000365016
    PPFIBP1Q86W923, ENSP000002284254I2D: score=2 STRING: ENSP00000228425
    MARK3P274483, ENSP000004113974I2D: score=2 STRING: ENSP00000411397
    PAK4O960133, ENSP000003510494I2D: score=2 STRING: ENSP00000351049
    RABEP1Q152763, ENSP000002624774I2D: score=2 STRING: ENSP00000262477
    SUV420H1Q4FZB73, ENSP000003058994I2D: score=2 STRING: ENSP00000305899
    UNC79Q9P2D83, ENSP000002563394I2D: score=1 STRING: ENSP00000256339
    CBWD2Q8IUF13, ENSP000002591994I2D: score=2 STRING: ENSP00000259199
    FAM83GA6ND363, ENSP000003432794STRING: ENSP00000343279 I2D: score=2 
    ADCK2Q7Z6953, ENSP000000728694I2D: score=1 STRING: ENSP00000072869
    ADORA3P337653, ENSP000003587304I2D: score=1 STRING: ENSP00000358730
    DDX6P261963, ENSP000002640184I2D: score=2 STRING: ENSP00000264018
    KLC4Q9NSK03, ENSP000002597084I2D: score=2 STRING: ENSP00000259708
    MLLT4P551963, ENSP000003836234I2D: score=1 STRING: ENSP00000383623
    SRSF1Q079553, ENSP000002589624I2D: score=2 STRING: ENSP00000258962
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0006915apoptotic process TAS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA15163635
    GO:0097193intrinsic apoptotic signaling pathway TAS--

    YWHAQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAQ available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    Search CenterWatch for drugs/clinical trials and news about YWHAQ / 1433T

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YWHAQ gene: 
    NM_006826.3  

    Unigene Cluster for YWHAQ:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
    Hs.74405  [show with all ESTs]
    Unigene Representative Sequence: NM_006826
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381844 ENST00000238081(uc002qzx.3) ENST00000474715 ENST00000446619
    ENST00000460093

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    Additional mRNA sequence: 

    AF070556.1 AK297624.1 AK302208.1 AK309462.1 AK316158.1 BC050601.1 BC056867.1 BC093019.1 
    BT020014.1 X56468.1 X57347.1 

    24/46 DOTS entries (see all 46):

    DT.91782977  DT.91898346  DT.100843216  DT.91782983  DT.91728702  DT.95249123  DT.120640215  DT.100884295 
    DT.95249166  DT.91901902  DT.100884298  DT.86852191  DT.100884268  DT.121011162  DT.100884272  DT.100884302 
    DT.121011197  DT.121224056  DT.97770024  DT.100804899  DT.100884293  DT.102839040  DT.120640233  DT.91714850 

    24/1318 AceView cDNA sequences (see all 1318):

    BF792240 BU149866 BM475163 BC050601 BI858795 BU567612 CR615240 BG780029 
    BM451828 AI061383 BG498584 BM788198 CB121110 BM980715 F02134 BI871518 
    CB123841 BQ019939 AA084637 BQ955126 BQ347549 BQ925373 AA187516 BE909106 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                          -           -                                             
    SP2:                          -           -     -                                       
    SP3:                          -           -     -     -     -                           
    SP4:                          -                                                         
    SP5:                                      -                                             


    ECgene alternative splicing isoforms for YWHAQ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAQ expression in normal human tissues (normalized intensities)      YWHAQ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCATCTCT
    YWHAQ Expression
    About this image


    YWHAQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Kidney (Urinary System)
             visceral organ/mesonephros/mesonephric mesenchyme   

    See YWHAQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAQ

    SOURCE GeneReport for Unigene cluster: Hs.74405

    UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
    Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta.
    Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared
    with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement

        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAQ: 
              mTOR Signaling in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAQ gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhaq1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.74(n)1
    99.59(a)1
      12 (8.31 cM)5
    226301  NM_011739.31  NP_035869.11 
     213900715 
    chicken
    (Gallus gallus)
    Aves YWHAQ1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 88.03(n)
    98.78(a)
      421932  NM_001006415.1  NP_001006415.1 
    lizard
    (Anolis carolinensis)
    Reptilia YWHAQ6
    Uncharacterized protein
    96(a)
    1 ↔ 1
    1(148381388-148402159)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044989.12   -- 78.78(n)    BC044989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.10682 Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more 83.4(n)    BC044412.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more
    77(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-26
    par-56
    14-3-3-like protein 1
    75(a)
    73(a)
    many ↔ many
    many ↔ many
    X(11603707-11605421)
    IV(11820505-11821924)
    rice
    (Oryza sativa)
    Liliopsida Os.26732 Rice mRNA for brain specific protein (S94 gene), complete more 77.55(n)    AK062077.1 


    ENSEMBL Gene Tree for YWHAQ (if available)
    TreeFam Gene Tree for YWHAQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAQ gene
    YWHAH2  YWHAE2  YWHAB2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAQ using alignment to 4 protein entries:     1433T_HUMAN (see all proteins):
    14-3-3 protein    YWHAB    YWHAZ    SFN    YWHAH    YWHAG
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAQ for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for YWHAQ (see all 9)
    PGOHUM00000239811 PGOHUM00000239865 PGOHUM00000247782 PGOHUM00000244499 PGOHUM00000240813


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1044 SNPs in YWHAQ are shown (see all 1044)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409278291,2
    --9723606(+) AATAAC/TAGCTA 1 -- ds50010--------
    rs1432994861,2
    C--9723616(+) ATTGTG/TATACT 1 -- ds50010--------
    rs116921121,2
    C,F,H--9723732(+) TGACAG/TGCATT 1 -- ds50017Minor allele frequency- T:0.17NA CSA WA 248
    rs1903986971,2
    --9723803(+) AAATTA/GCCTGA 1 -- ds50010--------
    rs1511918181,2
    C--9723813(+) AGAGAG/TCCAAC 1 -- ds50010--------
    rs789296741,2
    C,F--9723818(+) TCCAAC/TGCTTT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1403417241,2
    C--9723854(+) TGATTG/TTGCCC 1 -- ds50010--------
    rs1826118531,2
    C--9723972(+) TGCAAA/TGGGTT 1 -- ds50010--------
    rs75941,2
    C,F,H--9724267(-) ATTGTG/ACATTG 1 -- ut31 ese37Minor allele frequency- A:0.13NS WA NA 904
    rs1876803371,2
    --9724272(+) CACAAC/TGTGGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for YWHAQ (9724101 - 9771143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAQ:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv214045CNV Loss16902084

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609009    OMIM disorders: --

    20/25 diseases for YWHAQ (see all 25):    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    guillain-barre syndrome    noonan syndrome
    progressive supranuclear palsy    williams-beuren syndrome    lipodystrophy    frontotemporal dementia
    sporadic breast cancer    ataxia telangiectasia    dementia    hiv type 1
    insulin resistance    ataxia    ischemia    schizophrenia
    parkinson's disease    sarcoma    neuroblastoma    breast cancer

    3 diseases from the University of Copenhagen DISEASES database for YWHAQ:
    Alzheimer's disease     Progressive supranuclear palsy     Frontotemporal dementia

    YWHAQ for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): YWHAQ
    Human Genome Epidemiology (HuGE) Navigator: YWHAQ (2 documents)

    Export disorders for YWHAQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAQ gene, integrated from 9 sources (see all 251):
    (articles sorted by number of sources associating them with YWHAQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PubMed id 11080204)1, 2, 3 Malaspina A.... de Belleroche J. (2000)
    2. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    3. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    4. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2 Nagata-Ohashi K.... Mizuno K. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2 Fujita N.... Tsuruo T. (2002)
    8. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)1, 2 Sato S....Tsuruo T. (2002)
    9. 14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PubMed id 9360956)1, 2 Dubois T.... Aitken A. (1997)
    10. Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. (PubMed id 7603573)1, 2 Xiao B....Gamblin S.J. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10971 HGNC: 12854 AceView: YWHAQ Ensembl:ENSG00000134308 euGenes: HUgn10971
    ECgene: YWHAQ Kegg: 10971 H-InvDB: YWHAQ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YWHAQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YWHAQ gene:
    Search GeneIP for patents involving YWHAQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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