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YWHAQ Gene

protein-coding GIFtS: 69

GC02M009674

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
14-3-3 ^¹, ²
1C5 ^²
HS1 ^¹, ²
OTTHUMP00000015730 ^²

Descriptions
14-3-3 protein T-cell ^², ³
14-3-3 protein tau ^², ³
14-3-3 protein theta ^²
Protein HS1 ^³
protein tau ^²
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide ^²
tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide ^²

External Ids
HGNC: 12854¹
Entrez Gene: 10971²
UniProtKB: P27348³
Ensembl: ENSG00000134308⁷

Search outside databases for aliases for YWHAQ gene

Previous GC identifers: GC02M009507 GC02M009775 GC02M009745

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YWHAQ:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by

binding to phosphoserine-containing proteins. This highly conserved protein family is found in

both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This

gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR

a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the

repeat number and the disease. [provided by RefSeq]

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Gene Wiki entry for YWHAQ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YWHAQ gene

Entrez Gene cytogenetic band: 2p25.1 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25.2-p25.1

YWHAQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M009674: (about GC identifiers)

Start:	9,641,552 bp from pter
End:	9,688,557 bp from pter
Size:	47,006 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005334.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348 (See protein sequence)

Recommended Name: 14-3-3 protein theta

Size: 245 amino acids; 27764 Da

Subunit: Homodimer. Interacts with PCTK1 (By similarity). Interacts with SSH1. Interacts with

CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm

Subcellular location: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals

PDB structures from and Proteopedia :

2BTP (3D)

Secondary accessions: Q567U5 Q5TZU8 Q9UP48

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006817.1

ENSEMBL proteins:

ENSP00000371267 ENSP00000238081

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for YWHAQ
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for YWHAQ
	Recombinant Proteins from Abcam (14-3-3 Tau + Theta, 14-3-3 Tau)
	Human Recombinant Proteins from Abnova (YWHAQ)

OriGene Purified Recombinant Human Protein: YWHAQ

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	18029348

About this table

Antibodies for YWHAQ:

	Invitrogen Antibodies for YWHAQ
	Millipore Mono- and Polyclonal Antibodies for the study of YWHAQ
	Sigma-Aldrich Antibodies for YWHAQ
	R&D Systems Antibodies for YWHAQ (14-3-3 theta)
	Cell Signaling Technology (CST) Antibodies for YWHAQ (14-3-3 tau)
	Antibodies from Abcam (14-3-3 Tau + Theta, 14-3-3 Tau), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YWHAQ)
	Novus Biologicals Antibodies for YWHAQ

Assays for YWHAQ:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P27348

ProtoNet protein and cluster: P27348

1 Blocks protein family: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348

Similarity: Belongs to the 14-3-3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAQ)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006826

Applied Biosystems Silencer® siRNAs for YWHAQ

Sigma-Aldrich siRNA for YWHAQ

Sigma-Aldrich shRNA for YWHAQ

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YWHAQ
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006826
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006826
untagged cDNA clones in CMV expression vector (see all 2): NM_006826

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006826

UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Genatlas biochemistry entry for YWHAQ:

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,theta polypeptide

stratifin,with likely several forms,one expressed in the cytoplasmic of keratinocyte,another in T

cells,multifunctional regulator involved in cell-cyle control (checkpoint) and signal

transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ywhaq):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019904	protein domain specific binding	IEA	--
GO:0047485	protein N-terminus binding	IPI	11984006

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for YWHAQ (Your Favorite Gene powered by Ingenuity)

IGF-1 Signaling
PI3K/AKT Signaling
14-3-3-mediated Signaling
ERK/MAPK Signaling

GeneDecks YWHAQ for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for YWHAQ

5/129 Interacting proteins for YWHAQ (P27348^{1, 2} ENSP00000371267³) via UniProtKB, MINT, and/or STRING (see all 129 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDKN1B	P46527², ENSP00000228872³	MINT-17888 MINT-17889 STRING (score=.96)
RAF1	P04049¹, ENSP00000251849³	EBI-359854, EBI-365996 STRING (score=.96)
TSC2	P49815¹^,², ENSP00000219476³	EBI-359854, EBI-396587 MINT-14051 EBI-359854, EBI-396587 MINT-14051 STRING (score=.973)
BRAF	P15056¹^,², ENSP00000288602³	EBI-359854, EBI-365980 MINT-50372 EBI-359854, EBI-365980 MINT-50372 STRING (score=.752)
KIF5B	P33176¹^,²	EBI-359854, EBI-355878 MINT-50370 EBI-359854, EBI-355878 MINT-50370

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	IEA	--
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0045892	negative regulation of transcription, DNA-dependent	IDA	15163635

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for YWHAQ

Browse Small Molecules at Sigma-Aldrich

Compounds for YWHAQ available from Tocris Bioscience

Compound	Action	CAS number
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
Anti-14.3.3tau	Antibody recognizing 14.3.3tau
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAQ)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006826

Sigma-Aldrich siRNA for YWHAQ

Sigma-Aldrich shRNA for YWHAQ

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006826

REFSEQ mRNAs for YWHAQ gene:

NM_006826.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006826

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006826
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006826
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006826

Additional cDNA sequence:

AF070556.1 AK297624.1 AK302208.1 AK309462.1 AK316158.1 BC050601.1 BC056867.1 BC093019.1

BT020014.1 CR590208.1 CR590303.1 CR591592.1 CR594792.1 CR600718.1 CR603466.1 CR607940.1

CR613794.1 CR614998.1 CR615240.1 CR616469.1 CR616856.1 CR617682.1 CR620125.1 CR621014.1

CR624722.1 X56468.1 X57347.1

24/47 DOTS entries (see all 47 ):

DT.91782977 DT.91898346 DT.100843216 DT.91782983 DT.91728702 DT.95249123 DT.120640215 DT.100884295

DT.86852191 DT.95249166 DT.91901902 DT.100884298 DT.100884268 DT.121011162 DT.100884272 DT.100884302

DT.121011197 DT.121224056 DT.97770024 DT.100804899 DT.102839040 DT.120640233 DT.91714850 DT.95249114

24/1318 AceView cDNA sequences (see all 1318 ):

BQ183575 BU156724 BG120068 BF036398 BU783800 BQ217270 AL538563 BM312423

BQ019939 AU127949 BE783202 CB141537 BU189462 BG500225 CR616469 AU123463

AA464663 BQ267890 BE122826 BM015082 BU736079 BM853326 BU507432 BE018416

highest scoring ESTs for YWHAQ:

X56468 AA112514 AA224002 AA227007 AA314345 AA314500 AL039155 AL110333 AW976155 BC056867

Unigene Cluster for YWHAQ:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Hs.74405 [show with all ESTs]

Unigene Representative Sequence: NM_006826

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAQ

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c
SP1:									-				-
SP2:									-				-		-
SP3:									-				-		-		-		-
SP4:									-
SP5:													-

About this scheme

ECgene alternative splicing isoforms for YWHAQ

2 Ensembl transcripts including schematic representations:

ENST00000381844 ENST00000238081

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YWHAQ expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YWHAQ

¹ / ² / ³

8 probe-sets matching YWHAQ gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32530_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.00	X56468	1.00	1.00	1.00	1
409_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.00	X56468	1.00	1.00	1.00	1
213699_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA854017	0.20	1.00	0.72	1
212426_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF033313	0.60	1.00	0.82	1
200693_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006826	0.60	1.00	0.82	1
213699_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212426_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200693_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCCATCTCT

SOURCE GeneReport for Unigene cluster: Hs.74405
Expression variation in blood from EXPOLDB for YWHAQ
UniProtKB/Swiss-Prot: 1433T_HUMAN, P27348
Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in
kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic
amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in
individuals with predominant lower motor neuron involvement

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YWHAQ gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	YWHAQ¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	95.78(n) 100(a)	607060 XM_532871.2 XP_532871.1
chimpanzee (Pan troglodytes)	YWHAQ¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	99.86(n) 100(a)	470302 XM_525684.2 XP_525684.2
cow (Bos taurus)	YWHAQ¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	94.29(n) 100(a)	768311 XM_001252704.1 XP_001252705.1
mouse (Mus musculus)	Ywhaq⁵ 100039786¹	12⁵	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more⁵ predicted gene, 100039786¹	93.47(n)¹ 99.18(a)¹	100039786¹ XM_001473500.1¹ XP_001473550.1¹ AA409740⁵ AA636932⁵ (see all 43)
zebrafish (Danio rerio)	Dr.1068²	--	Danio rerio mRNA similar to tyrosine 3-monooxygenase/tryptophan more	83.4(n)	BC044412.1

About this table Species with no ortholog for YWHAQ

ENSEMBL Gene Tree for YWHAQ

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YWHAQ gene

YWHAB² SFN² YWHAZ²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/232 NCBI SNPs in YWHAQ are shown (see all 232 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 95)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2091210^1,2	C,F,H	9688651(-)	`CGGGAC/G/TAAGCT`	1	--	ng3¹		8		EU EA WA NA	780
	rs10203320^1,2	A,C	9689071(+)	`CTTTCC/TATCCG`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs11692112^1,2	C	9641183(+)	`tgacaG/Tgcatt`	1	--	ng5¹		0	--	--	--	--
--	rs7594^1,2	C	9641718(-)	`ATTGTA/GCATTG`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs16822436^1,2	F	9642774(-)	`AGAAAC/TCCATT`	1	--	ut3¹		1		MN	184
	rs1111976^1,2	A,C,F,H	9657006(-)	`aaagtC/Acttga`	1	--	int¹		8		EU EA WA	838
	rs7608161^1,2	A,C,F,H	9668060(+)	`ATATTA/GACATC`	1	--	int¹		11		EU EA WA NA	978
--	rs6432024^1,2	A,C,F,H	9660585(+)	`ggcatA/Gagcca`	1	--	int¹		4		EU EA WA	418
	rs6734469^1,2	A,C,F,H	9653351(+)	`TGTACG/ATTATT`	1	--	int¹		9		EU EA WA NS	524
	rs11676903^1,2	A,C,F,H	9680652(+)	`TGACTG/CAACTA`	1	--	int¹		7		EU EA WA NA	558

About this table

HapMap Linkage Disequilibrium images for YWHAQ (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609009

Human Genome Epidemiology Navigator: YWHAQ (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/97 PubMed articles for YWHAQ gene (see all 97 ):

A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. (PubMed id 11080204)^{2, 3, 4} Malaspina A.... de Belleroche J. (2000)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)^{3, 4} Nagata-Ohashi K.... Mizuno K. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)^{3, 4} Fujita N....Tsuruo T. (2002)
14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction. (PubMed id 9360956)^{3, 4} Dubois T....Aitken A. (1997)
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. (PubMed id 7603573)^{3, 4} Xiao B....Gamblin S.J. (1995)
Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)^{3, 4} Leffers H.... Celis J.E. (1993)
Primary structure of a human protein kinase regulator protein. (PubMed id 2015305)^{3, 4} Nielsen P.J. (1991)
14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. (PubMed id 12426317)^{1, 3} Nomura M....Tsujimoto Y. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10971	HGNC: 12854	AceView: YWHAQ	Ensembl:ENSG00000134308	euGenes: HUgn10971
ECgene: YWHAQ	H-InvDB: YWHAQ

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for YWHAQ
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YWHAQ:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YWHAQ-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YWHAQ		Antibodies for YWHAQ
	Explore super-pooled esiRNAs		Proteins for YWHAQ
	Lentivirus-delivered shRNAs for YWHAQ		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YWHAQ)
	Antibodies (YWHAQ)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for YWHAQ (14-3-3 tau)

	Recombinant Proteins (14-3-3 Tau + Theta, 14-3-3 Tau)
	Antibodies (14-3-3 Tau + Theta, 14-3-3 Tau)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for YWHAQ

	Drugs/Proteins for YWHAQ
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YWHAQ

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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YWHAQ Gene at Home site.
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YWHAQ Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for YWHAQ

Summaries
for YWHAQ

Genomic Location
for YWHAQ

Proteins
for YWHAQ

Protein Domains/
Families
for YWHAQ

Gene Function
for YWHAQ

Pathways & Interactions
for YWHAQ

Drugs & Compounds
for YWHAQ

Transcripts
for YWHAQ

Expression
for YWHAQ

Orthologs
for YWHAQ

Paralogs
for YWHAQ

SNPs/Variants
for YWHAQ

Disorders & Mutations
for YWHAQ

Medical News
for YWHAQ

Publications
for YWHAQ

Search for YWHAQ

Genome Databases showing YWHAQ

Other Databases showing YWHAQ

Specialized Databases showing YWHAQ

Licensable Technologies
for YWHAQ

Services
for YWHAQ

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YWHAQ Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor YWHAQ

Summariesfor YWHAQ

Genomic Locationfor YWHAQ

Proteinsfor YWHAQ

Protein Domains/Familiesfor YWHAQ

Gene Functionfor YWHAQ

Pathways & Interactionsfor YWHAQ

Drugs & Compoundsfor YWHAQ

Transcriptsfor YWHAQ

Expression for YWHAQ

Orthologsfor YWHAQ

Paralogsfor YWHAQ

SNPs/Variantsfor YWHAQ

Disorders & Mutationsfor YWHAQ

Medical Newsfor YWHAQ

Publicationsfor YWHAQ

Search for YWHAQ

Genome Databases showing YWHAQ

Other Databases showing YWHAQ

Specialized Databases showing YWHAQ

Licensable Technologiesfor YWHAQ

Servicesfor YWHAQ

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YWHAQ

Summaries
for YWHAQ

Genomic Location
for YWHAQ

Proteins
for YWHAQ

Protein Domains/
Families
for YWHAQ

Gene Function
for YWHAQ

Pathways & Interactions
for YWHAQ

Drugs & Compounds
for YWHAQ

Transcripts
for YWHAQ

Expression
for YWHAQ

Orthologs
for YWHAQ

Paralogs
for YWHAQ

SNPs/Variants
for YWHAQ

Disorders & Mutations
for YWHAQ

Medical News
for YWHAQ

Publications
for YWHAQ

Licensable Technologies
for YWHAQ

Services
for YWHAQ