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YWHAH Gene

protein-coding   GIFtS: 70
GCID: GC22P032340

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Eta1 2
YWHA11 2 3 5
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Eta Polypeptide1 2
14-3-3 Eta1 2
14-3-3 Protein Eta2
Protein AS13

External Ids:    HGNC: 128531   Entrez Gene: 75332   Ensembl: ENSG000001282457   OMIM: 1135085   UniProtKB: Q049173   
ORGUL members:         

Export aliases for YWHAH gene to outside databases

Previous GC identifers: GC22P029036 GC22P030665 GC22P015296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YWHAH Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence
in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and
psychotic bipolar disorder. (provided by RefSeq, Jun 2009)

GeneCards Summary for YWHAH Gene:
YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta) is a protein-coding gene. Diseases associated with YWHAH include early-onset schizophrenia, and bipolar disorder. GO annotations related to this gene include enzyme binding and protein heterodimerization activity. An important paralog of this gene is YWHAE.

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAH Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAH gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAH promoter sequence
   Search Chromatin IP Primers for YWHAH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.1-q13.1

YWHAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAH gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P032340:  view genomic region     (about GC identifiers)

Start:
32,340,447 bp from pter      End:
32,353,590 bp from pter
Size:
13,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917 (See protein sequence)
Recommended Name: 14-3-3 protein eta  
Size: 246 amino acids; 28219 Da
Subunit: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR,
ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction
retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B.
Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By
similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1
2 PDB 3D structures from and Proteopedia for YWHAH:
2C63 (3D)        2C74 (3D)    

Explore the universe of human proteins at neXtProt for YWHAH: NX_Q04917

Explore proteomics data for YWHAH at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By
    similarity)1
  • Ubiquitination2 at Lys50, Lys69, Lys110, Lys125, Lys127
  • Modification sites at PhosphoSitePlus

  • See YWHAH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003396.1  
    ENSEMBL proteins: 
     ENSP00000248975   ENSP00000408468   ENSP00000380629   ENSP00000406747  
    Reactome Protein details: Q04917

    YWHAH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for YWHAH
    OriGene Purified Protein for YWHAH
    OriGene Protein Over-expression Lysate for YWHAH
    OriGene MassSpec for YWHAH
    OriGene Custom Protein Services for YWHAH
    GenScript Custom Purified and Recombinant Proteins Services for YWHAH
    Novus Biologicals YWHAH Proteins
    Novus Biologicals YWHAH Lysate
    Sino Biological Recombinant Protein for YWHAH
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for YWHAH
    Browse Proteins at Cloud-Clone Corp.

    YWHAH Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
    R&D Systems Antibodies for YWHAH (14-3-3 eta)
    Cell Signaling Technology (CST) Antibodies for YWHAH  (14-3-3 eta)
    OriGene Antibodies for YWHAH
    OriGene Custom Antibody Services for YWHAH
    Novus Biologicals YWHAH Antibodies
    Abcam antibodies for YWHAH
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for YWHAH
    LSBio Antibodies in human, mouse, rat for YWHAH

    YWHAH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YWHAH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YWHAH
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry Q04917

    ProtoNet protein and cluster: Q04917

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Similarity: Belongs to the 14-3-3 family


    YWHAH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433F_HUMAN, Q04917
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAH:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 eta protein,multifunctional regulator
    involved in cell-cyle control (checkpoint), and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005159insulin-like growth factor receptor binding ISS--
    GO:0005515protein binding IPI10713667
    GO:0017080sodium channel regulator activity IDA16728661
    GO:0019899enzyme binding IPI17255105
         
    YWHAH for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ywhah (no phenotypes)

    YWHAH for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YWHAH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YWHAH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAH

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAH:
    hsa-mir-186-5p (MIRT021116), hsa-mir-16-5p (MIRT032075), hsa-mir-32-5p (MIRT028327), hsa-mir-103a-3p (MIRT027235), hsa-mir-324-5p (MIRT043064), hsa-mir-33a-5p (MIRT028247)

    Block miRNA regulation of human, mouse, rat YWHAH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YWHAH
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YWHAH

    Clone
    Products:
         
    OriGene clones in human, mouse for YWHAH (see all 6)
    OriGene ORF clones in mouse, rat for YWHAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
    Sino Biological Human cDNA Clone for YWHAH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for YWHAH
    Browse ESI BIO Cell Lines and PureStem Progenitors for YWHAH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA16728661
    GO:0014704intercalated disc IC16728661
    GO:0030659cytoplasmic vesicle membrane TAS--

    YWHAH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YWHAH About   (see all 46)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BAD and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAH
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAH (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAH
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAH
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAH
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for YWHAH (see all 18)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Alpha6-Beta4 Integrin Signaling Pathway


    2 Reactome Pathways for YWHAH
        Activation of BAD and translocation to mitochondria
    Translocation of GLUT4 to the plasma membrane


    Selected Kegg Pathways  (Kegg details for YWHAH) (see all 6):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Epstein-Barr virus infection


    YWHAH for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YWHAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAH (Q049171, 2, 3 ENSP000002489754) via UniProtKB, MINT, STRING, and/or I2D (see all 480) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25BP303051, 2, 3, ENSP000002459604EBI-306940,EBI-1051746 MINT-8007505 MINT-25118 MINT-19328 MINT-19330 I2D: score=4 STRING: ENSP00000245960
    HDAC4P565241, 2, 3, ENSP000002646064EBI-306940,EBI-308629 MINT-8008113 I2D: score=2 STRING: ENSP00000264606
    YWHAQP273482, 3, ENSP000002380814MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000238081
    PTH1RQ034312, 3, ENSP000003219994MINT-15642 MINT-15641 MINT-5207093 I2D: score=2 STRING: ENSP00000321999
    YWHAEP622582, 3, ENSP000002643354MINT-7300139 MINT-7899812 I2D: score=6 STRING: ENSP00000264335
    TSC2P498152, 3, ENSP000002194764MINT-16580 MINT-7899812 I2D: score=5 STRING: ENSP00000219476
    YWHABP319462, 3, ENSP000003001614MINT-7300139 MINT-7264099 I2D: score=2 STRING: ENSP00000300161
    ZBTB17Q131052, 3, ENSP000003648954MINT-8006807 MINT-8006814 I2D: score=1 STRING: ENSP00000364895
    PRKCIP417431, 3, ENSP000002957974EBI-306940,EBI-286199 I2D: score=5 STRING: ENSP00000295797
    ING1Q9UK532, 3, ENSP000003649294MINT-8007431 I2D: score=4 STRING: ENSP00000364929
    MAP3K5Q996832, 3, ENSP000003519084MINT-8007939 I2D: score=4 STRING: ENSP00000351908
    MARK4Q96L341, 3, ENSP000003008434EBI-306940,EBI-302319 I2D: score=4 STRING: ENSP00000300843
    PDPK1O155302, 3, ENSP000003442204MINT-15996 I2D: score=4 STRING: ENSP00000344220
    MDM4O151512, 3, ENSP000003561504MINT-1958584 I2D: score=3 STRING: ENSP00000356150
    CDK14O949211, 3, ENSP000002657414EBI-306940,EBI-1043945 I2D: score=2 STRING: ENSP00000265741
    CSNK1EP496742, 3, ENSP000003529294MINT-7264275 I2D: score=1 STRING: ENSP00000352929
    HNRNPDQ141032, 3, ENSP000003131994MINT-2881573 I2D: score=1 STRING: ENSP00000313199
    NEDD4LQ96PU52, 3, ENSP000003831994MINT-8006897 I2D: score=1 STRING: ENSP00000383199
    PRKD2Q9BZL62, 3, ENSP000002912814MINT-6177337 I2D: score=1 STRING: ENSP00000291281
    CEP250Q9BV732, 3MINT-7899812 I2D: score=1 
    PIAS2O759282, 3MINT-6542674 I2D: score=1 
    CAMKK1Q8N5S91, 2, 3, ENSP000001581664EBI-306940,EBI-6424030 MINT-6491259 MINT-6491287 MINT-6491322 MINT-6491274 MINT-6491300 I2D: score=2 STRING: ENSP00000158166
    YWHAGP619812, 3, ENSP000003063304MINT-7300139 MINT-6542674 MINT-7264099 MINT-7899812 I2D: score=2 STRING: ENSP00000306330
    MARK2Q7KZI71, 2, 3, ENSP000003891844EBI-306940,EBI-516560 MINT-8009011 MINT-8009018 I2D: score=3 STRING: ENSP00000389184
    YWHAZP631042, 3, ENSP000003095034MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=1 STRING: ENSP00000309503
    RAF1P040491, 2, 3, ENSP000002518494EBI-306940,EBI-365996 MINT-8005920 I2D: score=5 STRING: ENSP00000251849
    CBLP226812, 3, ENSP000002640334MINT-8005864 MINT-7899812 I2D: score=1 STRING: ENSP00000264033
    AKT1S1Q96B361, 2, 3, ENSP000003416984EBI-306940,EBI-720593 MINT-8006296 I2D: score=2 STRING: ENSP00000341698
    GREM1O605651, 2, 3, ENSP000003001774EBI-306940,EBI-944395 MINT-8007394 I2D: score=4 STRING: ENSP00000300177
    MAP3K3Q997592, 3, ENSP000003549274MINT-48492 MINT-47987 I2D: score=3 STRING: ENSP00000354927
    RIMS2Q9UQ263, ENSP000003862284I2D: score=4 STRING: ENSP00000390665 STRING: ENSP00000386228
    MARK3P274481, 3, ENSP000004113974EBI-306940,EBI-707595 I2D: score=2 STRING: ENSP00000411397
    PARD3Q8TEW01, 3, ENSP000003639214EBI-306940,EBI-81968 I2D: score=3 STRING: ENSP00000363921
    ARP102752, 3, ENSP000003638224MINT-8009652 I2D: score=1 STRING: ENSP00000363822
    GP1BAP073592, 3, ENSP000003293804MINT-8009056 I2D: score=1 STRING: ENSP00000329380
    KRT18P057832, 3, ENSP000003734874MINT-7899812 I2D: score=1 STRING: ENSP00000373487
    PARD6AQ9NPB61, 3, ENSP000002192554EBI-306940,EBI-81876 I2D: score=4 STRING: ENSP00000219255
    PARD6BQ9BYG51, 3, ENSP000003606724EBI-306940,EBI-295391 I2D: score=3 STRING: ENSP00000360672
    PARD6GQ9BYG41, 3, ENSP000003431444EBI-306940,EBI-295417 I2D: score=2 STRING: ENSP00000343144
    NEDD8Q158432, 3, ENSP000002504954MINT-6542674 I2D: score=1 STRING: ENSP00000250495
    TSC1Q925743, ENSP000002985524I2D: score=4 STRING: ENSP00000298552
    ABL1P005193, ENSP000003614234I2D: score=3 STRING: ENSP00000361423
    BADQ929343, ENSP000003091034I2D: score=3 STRING: ENSP00000309103
    CDK16Q005363, ENSP000004057984I2D: score=3 STRING: ENSP00000405798
    CDKN1BP465273, ENSP000002288724I2D: score=3 STRING: ENSP00000228872
    EPB41L3Q9Y2J23, ENSP000003411384I2D: score=3 STRING: ENSP00000341138
    FOXO3O435243, ENSP000003395274I2D: score=3 STRING: ENSP00000339527
    KLC3Q6P5973, ENSP000003758104I2D: score=3 STRING: ENSP00000375810
    REM1O756283, ENSP000002019794I2D: score=3 STRING: ENSP00000201979
    TLX2O437633, ENSP000002336384I2D: score=3 STRING: ENSP00000233638
    ARAFP103983, ENSP000003662444I2D: score=2 STRING: ENSP00000366244
    ARHGEF2Q929743, ENSP000003153254I2D: score=2 STRING: ENSP00000315325
    CCDC88AQ3V6T23, ENSP000003387284I2D: score=2 STRING: ENSP00000338728
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    CYFIP2Q96F073, ENSP000003909484I2D: score=2 STRING: ENSP00000390948
    DCAF7P619623, ENSP000003083444I2D: score=2 STRING: ENSP00000308344
    DMWDQ090193, ENSP000002702234I2D: score=2 STRING: ENSP00000270223
    DOCK7Q96N673, ENSP000003407424I2D: score=2 STRING: ENSP00000340742
    ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
    KCNH2Q128093, ENSP000002621864I2D: score=2 STRING: ENSP00000262186
    KIF23Q022413, ENSP000002603634I2D: score=2 STRING: ENSP00000260363
    MED1Q156483, ENSP000003006514I2D: score=2 STRING: ENSP00000300651
    NCOA2Q155963, ENSP000003999684I2D: score=2 STRING: ENSP00000399968
    PARK2O602603, ENSP000003558654I2D: score=2 STRING: ENSP00000355865
    RASSF8Q8NHQ83, ENSP000002828844I2D: score=2 STRING: ENSP00000282884
    SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
    THRAP108273, ENSP000002646374I2D: score=2 STRING: ENSP00000264637
    WDR20Q8TBZ33, ENSP000003354344I2D: score=2 STRING: ENSP00000335434
    ARHGEF28Q8N1W13, ENSP000002967944I2D: score=1 STRING: ENSP00000296794
    BCAR1P569453, ENSP000001623304I2D: score=1 STRING: ENSP00000162330
    C1QBPQ070213, ENSP000002256984I2D: score=1 STRING: ENSP00000225698
    CLASP1Q7Z4603, ENSP000002637104I2D: score=1 STRING: ENSP00000263710
    CLASP2O751223, ENSP000003525814I2D: score=1 STRING: ENSP00000352581
    EPB41L2O434913, ENSP000003384814I2D: score=1 STRING: ENSP00000338481
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    KCNMA1Q127913, ENSP000002866274I2D: score=1 STRING: ENSP00000286627
    KIF1BO603333, ENSP000002639344I2D: score=1 STRING: ENSP00000263934
    KIF1CO438963, ENSP000003208214I2D: score=1 STRING: ENSP00000320821
    KLC2Q9H0B63, ENSP000003148374I2D: score=1 STRING: ENSP00000314837
    LIMA1Q9UHB63, ENSP000003784004I2D: score=1 STRING: ENSP00000378400
    MAP3K2Q9Y2U53, ENSP000003434634I2D: score=1 STRING: ENSP00000343463
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MAST3O603073, ENSP000002628114I2D: score=1 STRING: ENSP00000262811
    MST1RQ049123, ENSP000002964744I2D: score=1 STRING: ENSP00000296474
    NADKO955443, ENSP000003416794I2D: score=1 STRING: ENSP00000341679
    OSBPL3Q9H4L53, ENSP000003154104I2D: score=1 STRING: ENSP00000315410
    PDZD11Q5EBL83, ENSP000002396664I2D: score=1 STRING: ENSP00000239666
    PTPN14Q156783, ENSP000003559234I2D: score=1 STRING: ENSP00000355923
    RAB11FIP1Q6WKZ43, ENSP000003313424I2D: score=1 STRING: ENSP00000331342
    REEP1Q9H9023, ENSP000001656984I2D: score=1 STRING: ENSP00000165698
    SAMSN1Q9NSI83, ENSP000003834114I2D: score=1 STRING: ENSP00000383411
    SLC25A6P122363, ENSP000003708084I2D: score=1 STRING: ENSP00000370808
    SNRPEP623043, ENSP000004005914I2D: score=1 STRING: ENSP00000400591
    TBC1D1Q86TI03, ENSP000002614394I2D: score=1 STRING: ENSP00000261439
    TP53BP2Q136253, ENSP000003419574I2D: score=1 STRING: ENSP00000341957
    TRIP11Q156433, ENSP000002676224I2D: score=1 STRING: ENSP00000267622
    ZFP36L2P479743, ENSP000002823884I2D: score=1 STRING: ENSP00000282388
    BRAFP150563, ENSP000002886024I2D: score=3 STRING: ENSP00000288602
    USP46P620683, ENSP000004078184I2D: score=2 STRING: ENSP00000407818
    SLC2A4P146723, ENSP000003209354I2D: score=1 STRING: ENSP00000320935
    TNFAIP3P215803, ENSP000002372894I2D: score=3 STRING: ENSP00000237289
    HSPA8P111423, ENSP000002273784I2D: score=1 STRING: ENSP00000227378
    CDC25CP303073, ENSP000003216564I2D: score=3 STRING: ENSP00000321656
    NR3C1P041503, ENSP000002315094I2D: score=3 STRING: ENSP00000231509
    HDAC7Q8WUI43, ENSP000000800594I2D: score=2 STRING: ENSP00000080059
    KIF5BP331763, ENSP000003070784I2D: score=2 STRING: ENSP00000307078
    TNIP3Q96KP63, ENSP000000575134I2D: score=1 STRING: ENSP00000057513
    USP43Q70EL43, ENSP000002851994I2D: score=2 STRING: ENSP00000285199
    CHRNA4P436813, ENSP000003592854I2D: score=3 STRING: ENSP00000359285
    TPH1P177523, ENSP000002500184I2D: score=1 STRING: ENSP00000250018
    BCRP112743, ENSP000003035074I2D: score=2 STRING: ENSP00000303507
    IRS1P355683, ENSP000003048954I2D: score=1 STRING: ENSP00000304895
    PIK3CAP423363, ENSP000002639674I2D: score=1 STRING: ENSP00000263967
    PRKCZQ055133, ENSP000003678304I2D: score=1 STRING: ENSP00000367830
    RIMS1Q86UR53, ENSP000002648394I2D: score=4 STRING: ENSP00000264839
    RPH3AQ9Y2J03, ENSP000004132544I2D: score=3 STRING: ENSP00000413254
    SNCAP378403, ENSP000003383454I2D: score=2 STRING: ENSP00000338345
    NEK1Q96PY63, ENSP000004080204I2D: score=4 STRING: ENSP00000408020
    REPS2Q8NFH82, ENSP000003498244MINT-7032343 STRING: ENSP00000349824
    ZFP36P266513, ENSP000002486734I2D: score=3 STRING: ENSP00000248673
    ULK2Q8IYT83, ENSP000003548774I2D: score=1 STRING: ENSP00000354877
    ESR2Q927313, ENSP000003439254I2D: score=2 STRING: ENSP00000343925
    NCOA1Q157883, ENSP000003209404I2D: score=2 STRING: ENSP00000320940
    NCOA3Q9Y6Q93, ENSP000003610664I2D: score=2 STRING: ENSP00000361066
    NRIP1P485523, ENSP000003272134I2D: score=2 STRING: ENSP00000327213
    KCNK3O146493, ENSP000003062754I2D: score=1 STRING: ENSP00000306275
    KCNK9Q9NPC23, ENSP000003021664I2D: score=1 STRING: ENSP00000302166
    OPTNQ96CV93, ENSP000002630364I2D: score=1 STRING: ENSP00000263036
    CYFIP1Q7L5763, ENSP000003245494I2D: score=2 STRING: ENSP00000324549
    MARK1Q9P0L23, ENSP000003558844I2D: score=2 STRING: ENSP00000355884
    TUBG1P232583, ENSP000002514134I2D: score=2 STRING: ENSP00000251413
    UBCP0CG482, ENSP000003448184MINT-6542674 STRING: ENSP00000344818
    TIAM1Q130093, ENSP000002868274I2D: score=1 STRING: ENSP00000286827
    CRTC1Q6UUV93, ENSP000003450014I2D: score=1 STRING: ENSP00000345001
    CGNQ9P2M73, ENSP000002716364I2D: score=1 STRING: ENSP00000271636
    CSNK1A1P487293, ENSP000002617984I2D: score=1 STRING: ENSP00000261798
    IRS2Q9Y4H23, ENSP000003650164I2D: score=1 STRING: ENSP00000365016
    KLC1Q078663, ENSP000004149824I2D: score=1 STRING: ENSP00000414982
    KSR1Q8IVT53, ENSP000002687634I2D: score=1 STRING: ENSP00000268763
    TBC1D4O603433, ENSP000003668634I2D: score=1 STRING: ENSP00000366863
    BAIAP2Q9UQB83, ENSP000003163384I2D: score=1 STRING: ENSP00000316338
    EIF4E2O605733, ENSP000002584164I2D: score=1 STRING: ENSP00000258416
    FAM53CQ9NYF33, ENSP000002399064I2D: score=1 STRING: ENSP00000239906
    KLC4Q9NSK03, ENSP000002597084I2D: score=1 STRING: ENSP00000259708
    LMO7Q8WWI13, ENSP000003421124I2D: score=1 STRING: ENSP00000342112
    LSRQ86X293, ENSP000003545754I2D: score=1 STRING: ENSP00000354575
    MAST2Q6P0Q83, ENSP000003546714I2D: score=1 STRING: ENSP00000354671
    MLLT4P551963, ENSP000003836234I2D: score=1 STRING: ENSP00000383623
    PAK4O960133, ENSP000003510494I2D: score=1 STRING: ENSP00000351049
    PFKFB2O608253, ENSP000003560474I2D: score=1 STRING: ENSP00000356047
    PKP2Q999593, ENSP000000708464I2D: score=1 STRING: ENSP00000070846
    RAB11FIP2Q7L8043, ENSP000003478394I2D: score=1 STRING: ENSP00000347839
    RABEP1Q152763, ENSP000002624774I2D: score=1 STRING: ENSP00000262477
    SHROOM2Q137963, ENSP000003702994I2D: score=1 STRING: ENSP00000370299
    USP8P408183, ENSP000003022394I2D: score=1 STRING: ENSP00000302239
    VAMP8Q9BV403, ENSP000002638644I2D: score=1 STRING: ENSP00000263864
    H2AFXP161042MINT-6542674 MINT-7899812
    MCM5P339922, ENSP000002161224MINT-6542674 STRING: ENSP00000216122
    RPS3P233962MINT-6542674 MINT-7899812
    SFNP319472MINT-7300139 MINT-7264099
    JUNP054123I2D: score=2 
    ABLIM1O146393I2D: score=1 
    ARRB1P494073I2D: score=1 
    ARRB2P321213I2D: score=1 
    CDK18Q070023I2D: score=1 
    DENND4AQ7Z4013I2D: score=1 
    GRB7Q144513I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    LARP1Q6PKG03I2D: score=1 
    MAP3K6O953823I2D: score=1 
    NFKBIAP259633I2D: score=1 
    PRKAB2O437413I2D: score=1 
    RELAQ042063I2D: score=1 
    SASH1O948853I2D: score=1 
    SH3BP4Q9P0V33I2D: score=1 
    SRGAP2O750443I2D: score=1 
    ULK1O753853I2D: score=1 
    ACTA2P627362MINT-7899812
    ACTBP607092MINT-7899812
    ACTG1P632612MINT-7899812
    ACTN2P356092MINT-7899812
    ACTN3Q080432MINT-7899812
    ANKRD18AQ8IVF62MINT-7899812
    ARHGEF4Q9NR802MINT-6542674
    ATP5A1P257052MINT-7899812
    BANK1Q8NDB22MINT-7899812
    CACNA1SQ136982MINT-7899812
    CALM1P621582MINT-7899812
    CALM2P621582MINT-7899812
    CALM3P621582MINT-7899812
    CUL1Q136162MINT-6542674
    CUL2Q136172MINT-6542674
    CUL3Q136182MINT-6542674
    CUL4AQ136192MINT-6542674
    CUL4BQ136202MINT-6542674
    CUL5Q930342MINT-6542674
    DDB1Q165312MINT-6542674
    DESP176612MINT-7899812
    EEF1A1P681042MINT-6542674
    EEF1A2Q056392MINT-6542674
    EEF2P136392MINT-6542674
    EGFRP005332MINT-7300139
    EIF2AQ9BY442MINT-6542674
    EMG1Q929792MINT-6542674
    ERCC4Q928892MINT-6542674
    GAB2Q9UQC22MINT-7300139
    GCN1L1Q926162MINT-6542674
    H1F0P073052MINT-7899812
    HARSP120812MINT-6542674
    HIST1H1CP164032MINT-7899812
    HIST1H1DP164022MINT-7899812
    HIST1H1TP224922MINT-7899812
    HIST1H2AGP0C0S82MINT-7899812
    HIST1H2AIP0C0S82MINT-7899812
    HIST1H2AKP0C0S82MINT-7899812
    HIST1H2ALP0C0S82MINT-7899812
    HIST1H2AMP0C0S82MINT-7899812
    HIST1H2BDP588762MINT-7899812
    HIST1H4AP628052MINT-7899812
    HIST1H4BP628052MINT-7899812
    HIST1H4CP628052MINT-7899812
    HIST1H4DP628052MINT-7899812
    HIST1H4EP628052MINT-7899812
    HIST1H4FP628052MINT-7899812
    HIST1H4HP628052MINT-7899812
    HIST1H4IP628052MINT-7899812
    HIST1H4JP628052MINT-7899812
    HIST1H4KP628052MINT-7899812
    HIST1H4LP628052MINT-7899812
    HIST2H2BEQ167782MINT-6542674
    HIST2H4AP628052MINT-7899812
    HIST2H4BP628052MINT-7899812
    HIST4H4P628052MINT-7899812
    HNRNPA2B1P226262MINT-7899812
    HNRNPCP079102MINT-7899812
    KRT17Q046952MINT-7899812
    KRT8P057872MINT-7899812
    LMNAP025452MINT-7899812
    LRRK2Q5S0071EBI-306940,EBI-5323863
    MCM4P339912MINT-6542674
    MYH11P357492MINT-7899812
    MYH13Q9UKX32MINT-7899812
    MYH2Q9UKX22MINT-7899812
    MYH3P110552MINT-7899812
    MYH7P128832MINT-7899812
    MYH9P355792MINT-7899812
    MYL12AP191052MINT-7899812
    MYL3P085902MINT-7899812
    MYLK2Q9H1R32MINT-7899812
    NAE1Q135642MINT-6542674
    NPM1P067482MINT-7899812
    PCNAP120042MINT-6542674
    PIAS1O759252MINT-6542674
    PRPF3O433952MINT-6542674
    RALYQ9UKM92MINT-7899812
    RPL10AP629062MINT-6542674
    RPL11P629132MINT-6542674
    RPL12P300502MINT-6542674
    RPL13P263732MINT-6542674
    RPL18Q070202MINT-6542674
    RPL21P467782MINT-6542674
    RPL23P628292MINT-6542674
    RPL24P837312MINT-6542674
    RPL26P612542MINT-6542674
    RPL27P613532MINT-6542674
    RPL29P479142MINT-6542674
    RPL30P628882MINT-6542674
    RPL31P628992MINT-6542674
    RPL35AP180772MINT-6542674
    RPL5P467772MINT-6542674
    RPL6Q028782MINT-6542674
    RPL7P181242MINT-6542674
    RPL7AP624242MINT-6542674
    RPL8P629172MINT-6542674
    RPL9P329692MINT-6542674
    RPL9P7P329692MINT-6542674
    RPL9P8P329692MINT-6542674
    RPL9P9P329692MINT-6542674
    RPS11P622802MINT-6542674
    RPS13P622772MINT-6542674
    RPS14P622632MINT-6542674
    RPS15AP622442MINT-6542674
    RPS16P622492MINT-6542674
    RPS2P158802MINT-6542674
    RPS20P608662MINT-6542674
    RPS23P622662MINT-6542674
    RPS26P628542MINT-6542674
    RPS4XP627012MINT-6542674
    RPS6P627532MINT-6542674
    RPS7P620812MINT-6542674
    RPS8P622412MINT-6542674
    SF3B3Q153932MINT-6542674
    SSRP1Q089452MINT-6542674
    SUMO3P558542MINT-6542674
    TARSP266392MINT-6542674
    TGIF2LYQ8IUE02MINT-7899812
    TPM1P094932MINT-7899812
    TTNQ8WZ422MINT-7899812
    TUBB2AQ138852MINT-7899812
    UBE2MP610812MINT-6542674
    USP42Q9H9J42MINT-7899812
    VASPP505522MINT-7899812
    VIMP086702MINT-7899812
    AKT1ENSP000002702024STRING: ENSP00000270202
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    FOXO1ENSP000003688804STRING: ENSP00000368880
    FOXO4ENSP000003633774STRING: ENSP00000363377
    MAP2K1ENSP000003024864STRING: ENSP00000302486
    MTORENSP000003545584STRING: ENSP00000354558
    PPP2R1AENSP000003248044STRING: ENSP00000324804
    PPP2R2BENSP000003365914STRING: ENSP00000336591
    RANENSP000003961274STRING: ENSP00000396127
    CBY1ENSP000002160294STRING: ENSP00000216029
    CRTC2ENSP000003058734STRING: ENSP00000305873
    CSNK1DENSP000003244644STRING: ENSP00000324464
    CSNK1G1ENSP000003057774STRING: ENSP00000305777
    CSNK1G2ENSP000002556414STRING: ENSP00000255641
    CSNK1G3ENSP000003539044STRING: ENSP00000353904
    DDIT4ENSP000003073054STRING: ENSP00000307305
    DEPTORENSP000002862344STRING: ENSP00000286234
    ITGA6ENSP000003868964STRING: ENSP00000386896
    ITGB4ENSP000002001814STRING: ENSP00000200181
    KPNA1ENSP000003437014STRING: ENSP00000343701
    LNPEPENSP000002313684STRING: ENSP00000231368
    MLST8ENSP000003718884STRING: ENSP00000371888
    PIN1ENSP000002479704STRING: ENSP00000247970
    PPP2R2AENSP000003701134STRING: ENSP00000370113
    PRKCAENSP000002843844STRING: ENSP00000284384
    SIK1ENSP000002701624STRING: ENSP00000270162
    SIK3ENSP000002920554STRING: ENSP00000292055
    VAMP2ENSP000003142144STRING: ENSP00000314214
    NGFRAP1ENSP000003617184STRING: ENSP00000361718
    ASIPENSP000003640924STRING: ENSP00000364092
    CENPKENSP000002428724STRING: ENSP00000242872
    GAMTENSP000004035364STRING: ENSP00000403536
    ADAM22ENSP000002657274STRING: ENSP00000265727
    SNCAIPENSP000002613684STRING: ENSP00000261368
    CD8BENSP000003311724STRING: ENSP00000331172
    DACT1ENSP000003374394STRING: ENSP00000337439
    EXO1ENSP000003118734STRING: ENSP00000311873
    KANK1ENSP000003717344STRING: ENSP00000371734
    PDK1ENSP000002820774STRING: ENSP00000282077
    KCNK15ENSP000003619524STRING: ENSP00000361952
    GRB2ENSP000003390074STRING: ENSP00000339007
    SRA1ENSP000003375134STRING: ENSP00000337513
    CBX4ENSP000002693974STRING: ENSP00000269397
    RASD1ENSP000002256884STRING: ENSP00000225688
    SIN3AENSP000003536224STRING: ENSP00000353622
    ATICENSP000002369594STRING: ENSP00000236959
    PSTPIP1ENSP000003689144STRING: ENSP00000368914
    RRM1ENSP000003007384STRING: ENSP00000300738
    TREHENSP000002640294STRING: ENSP00000264029
    KYENSP000003975984STRING: ENSP00000397598
    CHEK2ENSP000003720234STRING: ENSP00000372023
    ERCC5ENSP000003479784STRING: ENSP00000347978
    NEK11ENSP000003728574STRING: ENSP00000372857
    NSFENSP000003812934STRING: ENSP00000381293
    RPL4ENSP000003114304STRING: ENSP00000311430
    RPA1ENSP000002547194STRING: ENSP00000254719
    RRADENSP000002997594STRING: ENSP00000299759
    SIRT1ENSP000002120154STRING: ENSP00000212015
    MCATENSP000002904294STRING: ENSP00000290429
    NUMBENSP000003471694STRING: ENSP00000347169
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002028regulation of sodium ion transport IDA16728661
    GO:0006713glucocorticoid catabolic process IDA15790729
    GO:0006886intracellular protein transport ISS--
    GO:0006915apoptotic process TAS--
    GO:0021762substantia nigra development IEP--

    YWHAH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for YWHAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    1 Novoseek inferred chemical compound relationship for YWHAH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.8 1 16545136 (1)



    YWHAH for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for YWHAH gene: 
    NM_003405.3  

    Unigene Cluster for YWHAH:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
    Hs.226755  [show with all ESTs]
    Unigene Representative Sequence: NM_003405
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248975(uc003alz.3) ENST00000443669 ENST00000397492 ENST00000479649
    ENST00000471374(uc003ama.3 uc010gwm.3) ENST00000420430
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat YWHAH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for YWHAH
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAH
    Clone
    Products:
         
    OriGene clones in human, mouse for YWHAH (see all 6)
    OriGene ORF clones in mouse, rat for YWHAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH
    Primer
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    Additional mRNA sequence: 

    AK307750.1 AK312650.1 AY007132.1 BC003047.1 CR456612.1 L08439.1 L20422.1 S80794.1 
    X57345.1 X78138.1 

    Selected DOTS entries (see all 36):

    DT.95111929  DT.448876  DT.101976744  DT.100711364  DT.407748  DT.120670119  DT.91783556  DT.100851802 
    DT.100700123  DT.100637903  DT.97771863  DT.120670168  DT.95109036  DT.99965707  DT.100733502  DT.100847487 
    DT.100852063  DT.92342680  DT.100637738  DT.100647593  DT.100650467  DT.100647591  DT.100659038  DT.100662630 

    Selected AceView cDNA sequences (see all 810):

    CA407179 BU196763 BQ130708 BQ267143 CA397229 BM764472 CR603635 AU119302 
    BM765261 CR596702 F04963 CR596240 BU170128 AA605146 AI423963 BQ787495 
    BQ072030 BU786149 CR624998 CR456612 BU947953 AU142852 H11617 AI470204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YWHAH (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -                                       
    SP2:                    -     -           -     -                                 
    SP3:                    -     -     -     -     -                                 
    SP4:                    -                                                         
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for YWHAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    YWHAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATCAAGA
    YWHAH Expression
    About this image


    YWHAH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
    YWHAH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.226755

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAH: 
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              PI3K-AKT Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for YWHAH gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhah1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.22(n)1
    99.19(a)1
      5 (17.42 cM)5
    226291  NM_011738.21  NP_035868.11 
     330188165 
    chicken
    (Gallus gallus)
    Aves YWHAH1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 85.91(n)
    97.97(a)
      416955  NM_001007839.1  NP_001007840.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    2(118187473-118188219)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045230.12   -- 80.56(n)    BC045230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb51h042 Danio rerio cDNA clone MGC63883 IMAGE6789640, complete more 78.49(n)    BC053130.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M117.36
    Protein M117.3 (M117.3) mRNA, complete cds
    38(a)
    1 → many
    IV(11823371-11823938) WBGene00010919
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BMH16
    BMH26
    14-3-3 protein, major isoform; controls proteome a...
    14-3-3 protein, minor isoform; controls proteome a...
    56(a)
    55(a)
    many ↔ many
    many ↔ many
    V(545611-546414) YER177W
    IV(653607-654428) YDR099W


    ENSEMBL Gene Tree for YWHAH (if available)
    TreeFam Gene Tree for YWHAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for YWHAH gene
    YWHAE2  YWHAB2  YWHAQ2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAH using alignment to 4 protein entries:     1433F_HUMAN (see all proteins):
    YWHAG    YWHAB    YWHAZ    YWHAQ    SFN    14-3-3 protein
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for YWHAH (see all 232)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910129111,2
    --32343405(+) CACTTA/GATAAT 1 -- int10--------
    rs1831334371,2
    --32343452(+) CCAGCA/GTCACC 1 -- int10--------
    rs762705741,2
    C--32343478(+) GTAAGA/CTTGAA 1 -- int10--------
    rs1883118861,2
    C--32343508(+) AAACAA/GTGGTC 1 -- int10--------
    rs106317881,2
    C--32343613(+) TCAAGCTCT/-  
            
    CTCTA
    1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs343249181,2
    C--32343614(+) CAAGC-/CTCT  
            
    TCTAT
    1 -- int10--------
    rs1498527091,2
    C--32343662(+) AAGAAA/GTATTG 1 -- int10--------
    rs1466569501,2
    --32343680(+) TTCTAC/GAACCT 1 -- int10--------
    rs738842431,2
    C,F--32343831(+) ACCAGA/GTAGAT 1 -- int13Minor allele frequency- G:0.05WA NA 240
    rs9332261,2
    C,F,O,A,H--32343847(+) GTGGAT/CATTCA 1 -- int122Minor allele frequency- C:0.11EA NA MN NS 1606

    HapMap Linkage Disequilibrium report for YWHAH (32340447 - 32353590 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508731CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAH
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 113508    OMIM disorders: --

    18 diseases for YWHAH:    
    About MalaCards
    early-onset schizophrenia    bipolar disorder    schizophrenia    sporadic breast cancer
    lipodystrophy    insulin resistance    parkinson's disease    meningioma
    multiple sclerosis    myeloid leukemia    hiv-1    breast cancer
    squamous cell carcinoma    cervicitis    leukemia    endotheliitis
    cerebritis    neuronitis


    YWHAH for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for YWHAH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 2 10206237 (1), 11121172 (1)
    tumors 0 1 1578511 (1)

    Genetic Association Database (GAD): YWHAH
    Human Genome Epidemiology (HuGE) Navigator: YWHAH (4 documents)

    Export disorders for YWHAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for YWHAH gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with YWHAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain. (PubMed id 1578511)1, 2, 9 Ichimura-Ohshima Y.... Kuwano R. (J. Neurosci. Res. 1992)
    2. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. (PubMed id 8218406)1, 2, 9 Swanson K.D.... Joshi J.G. (Biochim. Biophys. Acta 1993)
    3. 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia. (PubMed id 10206237)1, 4, 9 Toyooka K....Takahashi Y. (Am. J. Med. Genet. 1999)
    4. Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia. (PubMed id 11121172)1, 4, 9 Bell R....Collier D.A. (Am. J. Med. Genet. 2000)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    6. Family-based association of YWHAH in psychotic bipolar disorder. (PubMed id 19160447)1, 4 Grover D....Potash J.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    8. [Association study between NPY and YWHAH gene polymorphisms and schizophrenia]. (PubMed id 16459651)1, 4 Wang H.S....He L. (Yi Chuan Xue Bao 2005)
    9. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (Nat. Cell Biol. 2005)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7533 HGNC: 12853 AceView: YWHAH Ensembl:ENSG00000128245 euGenes: HUgn7533
    ECgene: YWHAH Kegg: 7533 H-InvDB: YWHAH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for YWHAH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YWHAH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for YWHAH gene:
    Search GeneIP for patents involving YWHAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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