Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAH Gene

protein-coding   GIFtS: 65
GCID: GC22P032340

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...


(Previous symbol: YWHA1)
 Explore 15 diseases affiliated with
YWHAH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for YWHAH    

Aliases
for YWHAH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Eta
Polypeptide1 2
YWHA11 2 3 5
14-3-3 Eta2
14-3-3 Protein Eta2
Protein AS13

External Ids:    HGNC: 128531   Entrez Gene: 75332   Ensembl: ENSG000001282457   OMIM: 1135085   UniProtKB: Q049173   
ORGUL members:         

Export aliases for YWHAH gene to outside databases

Previous GC identifers: GC22P029036 GC22P030665 GC22P015296


Summaries
for YWHAH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YWHAH:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this
protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5'
UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic
bipolar disorder. (provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase
activity of PDPK1

summary for YWHAH:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAH


Genomic Views
for YWHAH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAH gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAH promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.1-q13.1

YWHAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAH gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P032340:  view genomic region     (about GC identifiers)

Start:
 32,340,447 bp from pter      End:
 32,353,590 bp from pter
Size:
 13,144 bases      Orientation:
 plus strand

Proteins
for YWHAH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917 (See protein sequence)
Recommended Name: 14-3-3 protein eta  
Size: 246 amino acids; 28219 Da
Subunit: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1,
ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in
the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2.
Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the
'Ser-241' phosphorylated form of PDPK1
2 PDB 3D structures from and Proteopedia for YWHAH:
2C63 (3D)        2C74 (3D)    

Explore the universe of human proteins at neXtProt for YWHAH: NX_Q04917

Post-translational modifications:

  • Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By
    • similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04917

    • YWHAH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003396.1  
    ENSEMBL proteins: 
     ENSP00000248975   ENSP00000408468   ENSP00000380629   ENSP00000406747  
    Reactome Protein details: Q04917
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for YWHAH
    OriGene Purified Protein: YWHAH
    OriGene Protein Over-expression Lysate: YWHAH
    OriGene Custom Protein Services for YWHAH 
    GenScript Custom Purified and Recombinant Proteins Services for YWHAH
    Novus Biologicals YWHAH Proteins
    Novus Biologicals YWHAH Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for YWHAH
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0014704intercalated disc IC16728661


    YWHAH for ontologies           About GeneDecksing



    YWHAH Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
    R&D Systems Antibodies for YWHAH (14-3-3 eta)
    Cell Signaling Technology (CST) Antibodies for YWHAH  (14-3-3 eta)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for YWHAH 
    GenScript Custom Superior Antibodies Services for YWHAH
    Novus Biologicals YWHAH Antibodies
    Search for Antibodies for YWHAH at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for YWHAH

    Assay Products for YWHAH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YWHAH
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for YWHAH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YWHAH for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry Q04917

    ProtoNet protein and cluster: Q04917

    1 Blocks protein family: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Similarity: Belongs to the 14-3-3 family


    Function
    for YWHAH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
    Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase
    activity of PDPK1

         Genatlas biochemistry entry for YWHAH:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 eta protein,multifunctional regulator
    involved in cell-cyle control (checkpoint), and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

    miRNA
    Products:            		 OriGene 3'-UTR Clone: YWHAH
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAH
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: YWHAH 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAH (see all 7)
    OriGene shRNA RFP: YWHAH
    OriGene siRNA: YWHAH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAH

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for YWHAH

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAH (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
    Sino Biological Human cDNA Clone for YWHAH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for YWHAH
    Search LifeMap BioReagents cell lines for YWHAH

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for YWHAH

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004497monooxygenase activity ----
    GO:0005159insulin-like growth factor receptor binding ISS--
    GO:0005515protein binding IPI--
    GO:0017080sodium channel regulator activity ISS--


    YWHAH for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Ywhah (no phenotypes)

    YWHAH for phenotypes           About GeneDecksing


    Pathways & Interactions
    for YWHAH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    2Apoptosis and survival BAD phosphorylation
    		Apoptosis and survival BAD phosphorylation1.00
    		BAD Phosphorylation0.41
    		Apoptosis and survival_BAD phosphorylation0.99
    3Cell cycle_Role of 14-3-3 proteins in cell cycle regulation
    		Cell cycle_Role of 14-3-3 proteins in cell cycle regulation1.00
    		14-3-3 and Cell Cycle Regulation0.45
    		Cell cycle Role of 14-3-3 proteins in cell cycle regulation1.00
    4BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    		Activation of BH3-only proteins0.30
    		Activation of BAD and translocation to mitochondria 0.15
    		Intrinsic Pathway for Apoptosis0.23
    5Immune response_Function of MEF2 in T lymphocytes
    		Immune response_Function of MEF2 in T lymphocytes1.00
    		Immune response Function of MEF2 in T lymphocytes0.90

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for YWHAH
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAH
        Apoptosis Signaling Pathways

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAH (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAH
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAH
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAH
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/17 BioSystems Pathways for YWHAH (see all 17) 
        Myometrial Relaxation and Contraction Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    TNF-alpha/NF-kB Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway

    5/6        Reactome Pathways for YWHAH (see all 6)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    3         Kegg Pathways  (Kegg details for YWHAH):
        Cell cycle
    Oocyte meiosis
    Neurotrophin signaling pathway


    YWHAH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/380 Interacting proteins for YWHAH (Q049171, 2, 3 ENSP000002489754) via UniProtKB, MINT, STRING, and/or I2D (see all 380)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK2Q7KZI71, 2, 3, ENSP000003891844EBI-306940,EBI-516560 MINT-8009011 MINT-8009018 I2D: score=3 STRING: ENSP00000389184
    GREM1O605651, 2, 3, ENSP000003001774EBI-306940,EBI-944395 MINT-8007394 I2D: score=4 STRING: ENSP00000300177
    YWHAGP619812, 3, ENSP000003063304MINT-7300139 MINT-6542674 MINT-7264099 MINT-7899812 I2D: score=2 STRING: ENSP00000306330
    YWHAQP273482, 3, ENSP000002380814MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000238081
    YWHAEP622582, 3, ENSP000002643354MINT-7300139 MINT-7899812 I2D: score=6 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002028regulation of sodium ion transport ISS--
    GO:0006713glucocorticoid catabolic process IDA15790729
    GO:0006886intracellular protein transport ISS--
    GO:0042921glucocorticoid receptor signaling pathway IDA15790729
    GO:0045664regulation of neuron differentiation ISS--


    YWHAH for ontologies           About GeneDecksing



    Drugs & Compounds
    for YWHAH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YWHAH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]
    1 Novoseek chemical compound relationship for YWHAH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.8 1 16545136 (1)

    Search CenterWatch for drugs/clinical trials and news about YWHAH / 1433F 

    Transcripts
    for YWHAH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for YWHAH gene: 
    NM_003405.3  

    Unigene Cluster for YWHAH:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
    Hs.226755  [show with all ESTs]
    Unigene Representative Sequence: NM_003405
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248975(uc003alz.3) ENST00000443669 ENST00000397492 ENST00000479649
    ENST00000471374(uc003ama.3 uc010gwm.3) ENST00000485296 ENST00000420430


    miRNA
    Products:             		 OriGene 3'-UTR Clone: YWHAH
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat YWHAH
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: YWHAH 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAH (see all 7)
    OriGene shRNA RFP: YWHAH
    OriGene siRNA: YWHAH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAH
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAH (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAH
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAH
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAH

    Additional cDNA sequence: 

    AK307750.1 AK312650.1 AY007132.1 BC003047.1 CR456612.1 L08439.1 L20422.1 S80794.1 
    X57345.1 X78138.1 

    24/36 DOTS entries (see all 36):

    DT.95111929  DT.448876  DT.101976744  DT.100711364  DT.407748  DT.120670119  DT.91783556  DT.100851802 
    DT.100700123  DT.100637903  DT.97771863  DT.120670168  DT.95109036  DT.99965707  DT.100733502  DT.100847487 
    DT.100852063  DT.92342680  DT.100637738  DT.100647593  DT.100650467  DT.100647591  DT.100659038  DT.100662630 

    810 AceView cDNA sequences (see top 24):

    BQ549222 BQ937845 BU152865 BQ879509 AL120082 BX417694 AI089839 CR622989 
    BQ000356 BX397091 BU677803 BU783343 BQ267763 BX430121 BE888276 BM876453 
    BQ270511 BU947249 CR618712 AA505883 BC003047 BQ424474 BQ424354 BX421313 
    BU784398 CR621211 BM511441 CR617238 BX334640 CR593529 BQ270751 BX428308 
    BM875604 BG282577 BU077574 CR600773 CR617151 BI496963 BE296713 BQ072271 
    BU781880 CR608665 AV708195 CA419756 BQ549881 CR625039 CR593097 BQ272406 
    BQ636834 BM019303 BU783553 CK300088 BU947358 BM557627 CA448024 CA416908 
    BF592036 R69858 BM313913 BM766007 CR611605 BU070776 AI083995 AA304626 
    N71711 BM741105 BM762239 BX443473 CR602331 CR600337 CR615843 BU620324 
    N99662 CB121832 BX458568 CR600694 BU781599 CR618980 BU786742 CR605523 
    BM800098 BQ026894 AW340648 BU786042 AA322961 BU786758 BX422151 BU947663 
    AW950283 BX090946 BQ718384 AA322911 BU782796 CR622695 CR614662 CR607383 
    BQ881925 CR601517 BM460508 AI124697 BU788995 AY007132 CR615723 CR614377 
    BU788064 CR614044 BI094315 CK820399 BQ774429 F08031 BQ614641 CR619423 
    BQ001581 BU789255 H25293 AI824798 CR593026 BM565001 CR606891 BX459999 
    CR611926 BM309956 AI652885 H11617 AI470204 BU070050 AU142852 BU947953 
    CR456612 CR624998 BU786149 BQ072030 BQ787495 AA605146 AI423963 BU170128 
    F04963 CR596240 CR596702 BM765261 BM764472 AU119302 CR603635 CA397229 
    BQ267143 BQ130708 BU196763 CA407179 BX410648 BM765577 BU070540 CR607325 
    AA262704 CR616670 BF976019 CB112192 AA322873 BQ130452 AA608688 BQ720737 
    BU507953 AA084101 BX449331 AI377985 BX424740 AI523661 CD106006 AI697089 
    AW131665 H21979 AA565955 AW339607 BQ108596 W46595 BX444544 BX428307 
    BX325463 BM313650 BX461039 BQ614437 BX461569 BG676414 BX430638 BE888233 
    BX451230 BX445083 BX457573 BI553495 BX410647 BU616641 AA033522 BU069819 
    BX424802 BU632283 BI710752 BX438776 BX334639 BX444545 BQ581980 BQ549947 
    BU786740 BX410646 CD641276 BX428514 CD675184 BQ000465 BX453371 BX411972 
    BX367495 AI811116 R84813 D54224 CD368235 BX444527 BQ477302 BE814866 
    AA385288 BG261356 AA305009 BX430415 BI458375 BU947929 CB955842 BM310234 
    X78138 BX449627 CB132272 BX433692 CD513534 BQ694777 BX488634 BQ016524 
    BI711078 BX424640 BM273004 AI469689 AA724049 BM854775 BG939820 AI342365 
    BM746236 AW170272 BQ549730 BX407205 BX449337 BG188026 H25337 BQ937748 
    BQ549247 CA448290 BX407442 BI600395 BX451238 W46596 BG259939 BX444830 
    BX446529 BQ882105 BM985145 L08439 BI765070 BX427546 BE877957 BE909424 
    BX409401 BX389195 BX430475 BX424741 AI359738 AA700018 BX412798 AA256774 
    BU596569 BX325310 BX407109 BX377096 W65437 BX403926 AA126874 BX424739 
    BU521987 BI224443 H67636 AA720684 BI667275 BM510608 BI224762 BX407270 
    BF350700 AA361357 BX418873 BX420988 BU929972 N31547 BG705953 AA151067 
    BM876194 BU070236 BI598754 BE464590 BQ014583 CF618754 AA299055 BX325462 
    AI086877 CD676916 AL583492 BX413707 BX453370 BQ328374 AW340217 CF618755 
    AA223241 BX440729 BQ549706 BG748073 BF969152 BX407164 BG705941 BU781596 
    BI021827 BX410906 CK820398 AI082748 BX428532 BX333327 BM512401 BQ613833 
    BX407005 CK004604 BM763885 BX409217 AA340253 AW956548 W59944 BX443124 
    AI191245 BX387144 AI039008 BX366088 BX434705 BG777200 AI077943 AA321827 
    BP368685 BX413831 BI869271 BX458220 BQ614095 BX461772 CB305606 BU616256 
    BX458567 CB145838 BX449681 BG874344 CK005021 CD676053 BM669503 BX409268 
    BX330909 BX409400 AA343750 BX407175 BU615434 AL537425 BX410656 BG679243 
    BM979067 AI359337 AV722137 BX407052 CA445638 BI603754 BX430399 AI089749 
    BG714746 BX453372 BU071396 BU618255 BX325309 BX352763 BX418832 AA491574 
    N29226 AW602163 BE783112 T28031 BX444528 AI125315 BX333326 W47413 
    BX346466 BQ631080 BX407022 BP429417 BX407326 BM792064 BE881921 BX407430 
    BX445128 BM467808 AW274143 BU735417 BQ072615 BX454862 AA909983 BX414172 
    BG687334 BI669267 BX430446 BX409215 BX428240 BU069498 BF923383 BX463844 
    BX444552 NM_003405 H82692 AI199076 BX428306 BI458091 BX449514 BP341182 
    BQ436691 CB155380 BM827522 BM875351 BM926555 N69107 BI597630 BX451231 
    BF037999 BX462021 AW274142 W61343 CF242796 BX424801 BG283468 BQ187025 
    BM272753 CB997003 BX455649 BG716112 BU069718 BQ614284 BX409185 BI666601 
    W16498 CB155066 BM696838 BM824994 BF998207 BX428460 X57345 BU071630 
    BX445140 AW383484 BX407021 AW799101 BX453193 AW028427 T11718 AW401377 
    BX423476 AV726024 AV727437 W94135 AI086917 BM855922 AI218477 AV689560 
    BI553534 BX417693 AL534332 BX449626 BX428369 AW799289 BF966138 AA629032 
    AI310394 BX397090 BQ309138 BQ550033 BQ581651 BI547668 CD558290 BF340329 
    BX341148 BQ315724 BX403072 AV698274 BG874328 AA155615 BX424800 BG714752 
    BX433614 BQ300360 AI087141 AU160053 AW383504 BX388313 BM802305 BG105643 
    BQ310804 BI603891 AA367935 BG393010 BQ315627 BG980194 BX428421 BX449512 
    BQ272370 BG188574 BI458109 BI600851 AL120538 BG506219 BX428488 BE614089 
    BU677028 N20527 BF954720 BP375269 BX409600 BG708622 H79625 BQ315623 
    AA862331 BM794660 H11706 AI829449 BE350791 AA127798 BF381178 BE884042 
    BG468577 L20422 CK024093 BE939987 W47608 BF350708 BX428607 BX455352 
    BQ315624 BF904442 BX407178 BX427545 BF104759 BG542906 BX420224 BI018411 
    BX391125 H67097 S80794 BQ303036 BU783099 BG704479 BG002538 AV683116 
    AI085941 BX445127 D54950 AA156681 BQ315626 BI544692 BI544892 BI546644 
    AA864930 BI552434 AI248943 BQ300387 BF846801 CD617074 AU127209 AI352558 
    BI837163 BG716294 AA134368 BE614558 BF823250 BI550662 AI655561 BE541188 
    BF951911 BX410657 BF834912 W85827 BE621334 BX451131 BI554008 AU077248 
    AA084159 BX418334 BE538808 BX444551 AI608761 W65436 AW403970 AA150478 
    T15405 W85826 BQ614191 BX409575 AI248541 BX449524 BE885682 BX377095 
    BQ777854 BF945743 BF947918 AI188296 BQ315725 BI910773 BF951840 AU145681 
    BE885276 N74377 BF759170 BE731760 AW271187 BX465044 H79624 AA249581 
    AI831016 AA740589 H78021 BQ303037 AI917740 W03139 BI028364 BF935343 
    W02577 BX445139 W46459 BE540903 BE540842 AW999584 BF688115 BI599923 
    AA033938 BX428305 AW998929 N85248 AA150830 BX421312 BX428438 CD617072 
    AA938406 BF882509 AW382095 AA192540 BF768011 AA662875 BI091029 BE002724 
    AW664539 BX435407 R69901 W94127 AA988608 AW835019 BE842983 AI922133 
    AW995424 BP429484 CD617075 BX425112 BX449483 BF800387 AA872478 BM809320 
    BX418333 H60980 BX445082 AI811102 BC015595 BE960793 AA374252 W94040 
    H69844 BF816591 AI766457 CD617077 N79982 AI911682 N21530 AA513281 
    AI359620 BE155394 BQ720192 BX449340 AI279782 AA491520 BX340887 AW383636 
    BI603662 BX391124 BX465045 BX421315 AW799105 AA776573 BX410905 BE830649 
    CD617073 BE155344 AA487004 CD102372 BG055114 C03366 AW799290 W94022 
    BG419548 BQ339540 BI018331 AW273118 BF378634 BX442834 BI493502 AI261476 
    BE782494 BX442321 N90630 BX428238 BI113912 R82553 N74429 AV694829 
    AW166100 D82630 CD697641 BX449542 BE830609 AI421367 R25364 AW799292 
    AA171496 AA303717 AW799109 AA033631 AI904208 AW900930 CB996353 AI174338 
    AW084401 AI082545 AA192465 AI904207 H23204 BQ308898 BQ308909 AI864305 
    BQ300356 AI554181 BM922356 AI866231 BF969911 AI579932 AA219489 AW799107 
    AA223125 AI473820 AA774536 H78020 BX410907 BX449497 BX430620 AV707753 
    BX461826 BX446166 BX430734 AA908944 BF945817 AI635674 AW152629 AW799103 
    BP347261 CB112861 AI272249 H69864 AW150042 BX410655 AA775958 BX453373 
    C21397 BE167441 BX428333 BX430414 BU146280 AA905196 BE170015 CD617076 
    AA219627 BX428239 CB995416 AA096126 AI205606 AW894663 H13301 BF892648 
    AW894624 BX449496 H22042 BQ941537 BI545389 BI225166 R82499 BX424725 
    BX449607 BE826519 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAH (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -                                       
    SP2:                    -     -           -     -                                 
    SP3:                    -     -     -     -     -                                 
    SP4:                    -                                                         
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for YWHAH

    Expression
    for YWHAH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAATCAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See YWHAH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAH

    SOURCE GeneReport for Unigene cluster: Hs.226755

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels

        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAH
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAH
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for YWHAH

    Orthologs
    for YWHAH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAH gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves YWHAH1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 85.91(n)
    97.97(a)    		   416955  NM_001007839.1  NP_001007840.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC045230.12   -- 80.56(n)    BC045230.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb51h042 Danio rerio cDNA clone MGC63883 IMAGE6789640, complete more 78.49(n)    BC053130.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more    		 73(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ftt-26
    par-56
    (see all 3)    		 14-3-3-like protein 1
    (see all 3)    		 74(a)
    73(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 X(11603640-11605354)
    IV(11820482-11821901)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons 14-3-3EPSILON6
    GRF36
    (see all 14)    		 14-3-3-like protein GF14 psi
    (see all 14)    		 57(a)
    57(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 1(7878769-7881219)
    5(15409697-15411516)
    rice
    (Oryza sativa)    		 Liliopsida GF14c6
    GF14f6
    (see all 8)    		 14-3-3 protein, putative, expressed
    (see all 8)    		 56(a)
    55(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 8(20809790-20812919)
    3(28656820-28661023)


    ENSEMBL Gene Tree for YWHAH (if available)
    TreeFam Gene Tree for YWHAH (if available) 

    Paralogs
    for YWHAH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAH gene
    YWHAE2  YWHAQ2  YWHAB2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAH using alignment to 4 protein entries:     1433F_HUMAN (see all proteins):
    YWHAG    YWHAB    YWHAZ    YWHAQ    SFN    14-3-3 protein
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAH for paralogs           About GeneDecksing



    Genomic Variants
    for YWHAH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 NCBI SNPs in YWHAH are shown (see all 286)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs738842411,2
    		C,--32338615(+) CTCCCA/GTCTCT 2 -- int1 us2k12Minor allele frequency- G:0.16WA 120
    rs1420837981,2
    		--32338644(+) ATGGGC/GGGTGG 2 -- int1 us2k10--------
    rs1511459461,2
    		--32338668(+) TTACTA/CTCTAG 2 -- us2k1 int10--------
    rs1402635161,2
    		--32339002(+) TAAGGA/GTCCTG 2 -- us2k1 int10--------
    rs1919839771,2
    		--32339121(+) CCTCCC/GTTCTC 2 -- us2k1 int10--------
    rs803225191,2
    		C--32339183(+) CTTCCA/CAATTA 2 -- int1 us2k10--------
    rs96093911,2
    		F,--32339185(+) TCCCAA/GTTACC 2 -- us2k1 int11Minor allele frequency- G:0.09NA 120
    rs9290361,2
    		C,F,A,H,--32339213(+) ATCTTC/TGGCCT 2 -- int1 us2k142Minor allele frequency- T:0.47EA NA NS WA CSA 5051
    rs1453713391,2
    		--32339275(+) TTAGGC/TCTCTC 2 -- us2k1 int10--------
    rs59981851,2
    		--32339365(+) CAAGAC/TCCAGC 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for YWHAH (32340447 - 32353590 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YWHAH: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YWHAH
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAH

    Disorders / Diseases
    for YWHAH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YWHAH for disorders           About GeneDecksing

    OMIM gene information: 113508    OMIM disorders: --

    15 diseases for YWHAH:    About MalaCards
    bipolar disorder    schizophrenia    sporadic breast cancer    insulin resistance
    squamous cell carcinoma    lipodystrophy    myeloid leukemia    parkinson's disease
    breast cancer    leukemia    immunodeficiency    carcinoma
    malaria    neuronitis    alcoholism

    2 Novoseek disease relationships for YWHAH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 2 10206237 (1), 11121172 (1)
    tumors 0 1 1578511 (1)

    Genetic Association Database (GAD): YWHAH
    Human Genome Epidemiology (HuGE) Navigator: YWHAH (4 documents)

    Export disorders for YWHAH gene to outside databases

    Publications
    for YWHAH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAH gene, integrated from 9 sources (see all 125):
    (articles sorted by number of sources associating them with YWHAH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain. (PubMed id 1578511)1, 2, 9 Ichimura-Ohshima Y.... Kuwano R. (1992)
    2. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. (PubMed id 8218406)1, 2, 9 Swanson K.D.... Joshi J.G. (1993)
    3. 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia. (PubMed id 10206237)1, 4, 9 Toyooka K....Takahashi Y. (1999)
    4. Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia. (PubMed id 11121172)1, 4, 9 Bell R....Collier D.A. (2000)
    5. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    6. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. 14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta. (PubMed id 12480176)1, 4 Ubl A....Riess O. (2002)

    External Searches for YWHAH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing YWHAH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7533 HGNC: 12853 AceView: YWHAH Ensembl:ENSG00000128245 euGenes: HUgn7533
    ECgene: YWHAH Kegg: 7533 H-InvDB: YWHAH

    Other Databases showing YWHAH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing YWHAH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YWHAH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YWHAH Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for YWHAH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for YWHAH gene:
    Search GeneIP for patents involving YWHAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for YWHAH gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for YWHAH (14-3-3 eta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for YWHAH  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAH   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAH  
     OriGene Protein Over-expression Lysate for YWHAH   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for YWHAH   OriGene 3'-UTR Clone for YWHAH  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAH   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for YWHAH  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for YWHAH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for YWHAH   OriGene Custom Protein Services for YWHAH  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YWHAH
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YWHAH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
     GenScript Custom Purified and Recombinant Proteins Services for YWHAH GenScript cDNA clones with any tag delivered in your preferred vector for YWHAH
     GenScript Custom Assay Services for YWHAH GenScript Custom Superior Antibodies Services for YWHAH
     GenScript Custom overexpressing Cell Line Services for YWHAH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for YWHAH 
    (14-3-3 eta)

     Regulatory tfbs in YWHAH promoter
     Search Chromatin IP Primers for YWHAH
     RT2 qPCR Primer Assay in human, mouse, rat YWHAH
     GNC Network for YWHAH
     SABiosciences PCR Arrays including human, mouse, rat YWHAH
     Tocris compounds for YWHAH
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for YWHAH
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for YWHAH
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     YWHAH antibodies
     YWHAH proteins
     YWHAH lysates
     Search for Antibodies for YWHAH at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for YWHAH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for YWHAH




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for YWHAH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for YWHAH
     SwitchGear 3'UTR luciferase reporter plasmids for YWHAH
     SwitchGear Promoter luciferase reporter plasmids for YWHAH
     Search ThermoFisher Antibodies for YWHAH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      YWHAH gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4