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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAH Gene

protein-coding   GIFtS: 69
GCID: GC22P032340

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...


(Previous symbol: YWHA1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Eta Polypeptide1 2
YWHA11 2 3 5
14-3-3 Eta1 2
14-3-3 Protein Eta2
Protein AS13

External Ids:    HGNC: 128531   Entrez Gene: 75332   Ensembl: ENSG000001282457   OMIM: 1135085   UniProtKB: Q049173   
ORGUL members:         

Export aliases for YWHAH gene to outside databases

Previous GC identifers: GC22P029036 GC22P030665 GC22P015296


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for YWHAH Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence
in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and
psychotic bipolar disorder. (provided by RefSeq, Jun 2009)

GeneCards Summary for YWHAH Gene: 
YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide) is a protein-coding gene. Diseases associated with YWHAH include early-onset schizophrenia, and bipolar disorder, and among its related super-pathways are Cell cycle and Cell cycle Role of 14-3-3 proteins in cell cycle regulation. GO annotations related to this gene include actin binding and protein domain specific binding. An important paralog of this gene is YWHAE.

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAH Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAH gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAH promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.1-q13.1

YWHAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAH gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P032340:  view genomic region     (about GC identifiers)

Start:
32,340,447 bp from pter      End:
32,353,590 bp from pter
Size:
13,144 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917 (See protein sequence)
Recommended Name: 14-3-3 protein eta  
Size: 246 amino acids; 28219 Da
Subunit: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR,
ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction
retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B.
Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By
similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1
2 PDB 3D structures from and Proteopedia for YWHAH:
2C63 (3D)        2C74 (3D)    

Explore the universe of human proteins at neXtProt for YWHAH: NX_Q04917

Explore proteomics data for YWHAH at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04917

  • YWHAH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    YWHAH Protein Expression
    REFSEQ proteins: NP_003396.1  
    ENSEMBL proteins: 
     ENSP00000248975   ENSP00000408468   ENSP00000380629   ENSP00000406747  
    Reactome Protein details: Q04917
    Human Recombinant Protein Products for YWHAH: 
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    Novus Biologicals YWHAH Lysate
    Sino Biological Recombinant Protein for YWHAH
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for YWHAH
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA16728661
    GO:0014704intercalated disc IC16728661
    GO:0030659cytoplasmic vesicle membrane TAS--

    YWHAH for ontologies           About GeneDecksing



    YWHAH Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry Q04917

    ProtoNet protein and cluster: Q04917

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Similarity: Belongs to the 14-3-3 family


    YWHAH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433F_HUMAN, Q04917
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAH:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 eta protein,multifunctional regulator
    involved in cell-cyle control (checkpoint), and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005159insulin-like growth factor receptor binding ISS--
    GO:0005515protein binding IPI10713667
    GO:0017080sodium channel regulator activity IDA16728661
    GO:0019899enzyme binding IPI17255105
         
    YWHAH for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ywhah (no phenotypes)

    YWHAH for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for YWHAH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for YWHAH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAH 

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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for YWHAH About   (see all 46)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Intrinsic Pathway for Apoptosis0.63
    Activation of BAD and translocation to mitochondria 0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for YWHAH
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAH
        Apoptosis Signaling Pathways

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAH (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAH
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAH
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAH
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/18 BioSystems Pathways for YWHAH (see all 18)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    Calcium Regulation in the Cardiac Cell
    SIDS Susceptibility Pathways
    Alpha6-Beta4 Integrin Signaling Pathway


    5/6        Reactome Pathways for YWHAH (see all 6)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    5/6         Kegg Pathways  (Kegg details for YWHAH) (see all 6):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Epstein-Barr virus infection


    YWHAH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/382 Interacting proteins for YWHAH (Q049171, 2, 3 ENSP000002489754) via UniProtKB, MINT, STRING, and/or I2D (see all 382)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK2Q7KZI71, 2, 3, ENSP000003891844EBI-306940,EBI-516560 MINT-8009011 MINT-8009018 I2D: score=3 STRING: ENSP00000389184
    GREM1O605651, 2, 3, ENSP000003001774EBI-306940,EBI-944395 MINT-8007394 I2D: score=4 STRING: ENSP00000300177
    YWHAGP619812, 3, ENSP000003063304MINT-7300139 MINT-6542674 MINT-7264099 MINT-7899812 I2D: score=2 STRING: ENSP00000306330
    YWHAQP273482, 3, ENSP000002380814MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000238081
    YWHAEP622582, 3, ENSP000002643354MINT-7300139 MINT-7899812 I2D: score=6 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002028regulation of sodium ion transport IDA16728661
    GO:0006713glucocorticoid catabolic process IDA15790729
    GO:0006886intracellular protein transport ISS--
    GO:0006915apoptotic process TAS--
    GO:0042921glucocorticoid receptor signaling pathway IDA15790729

    YWHAH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YWHAH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    1 Novoseek inferred chemical compound relationship for YWHAH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.8 1 16545136 (1)

    Search CenterWatch for drugs/clinical trials and news about YWHAH / 1433F

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for YWHAH gene: 
    NM_003405.3  

    Unigene Cluster for YWHAH:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
    Hs.226755  [show with all ESTs]
    Unigene Representative Sequence: NM_003405
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248975(uc003alz.3) ENST00000443669 ENST00000397492 ENST00000479649
    ENST00000471374(uc003ama.3 uc010gwm.3) ENST00000420430
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAH

    Additional mRNA sequence: 

    AK307750.1 AK312650.1 AY007132.1 BC003047.1 CR456612.1 L08439.1 L20422.1 S80794.1 
    X57345.1 X78138.1 

    24/36 DOTS entries (see all 36):

    DT.95111929  DT.448876  DT.101976744  DT.100711364  DT.407748  DT.120670119  DT.91783556  DT.100851802 
    DT.100700123  DT.100637903  DT.97771863  DT.120670168  DT.95109036  DT.99965707  DT.100733502  DT.100847487 
    DT.100852063  DT.92342680  DT.100637738  DT.100647593  DT.100650467  DT.100647591  DT.100659038  DT.100662630 

    810 AceView cDNA sequences (see top 24):

    BQ000356 BC003047 BU784398 CR624998 F04963 CR616670 BU070540 BX430121 
    BX397091 BQ424474 CA397229 AI089839 BQ787495 BQ072030 BU677803 BQ270511 
    BQ267143 BU196763 BU783343 BQ549222 BX417694 AI423963 BQ267763 BQ879509 
    BU170128 AL120082 BQ937845 BU152865 BU947953 BM765261 AA505883 BX421313 
    CR618712 BE888276 CR622989 CR600337 CR602331 BX443473 BM762239 N71711 
    BM313913 BM741105 BU070776 AA304626 AI083995 CR611605 BM766007 CA416908 
    R69858 BF592036 BM557627 CA448024 CK300088 BU947358 BM019303 BU783553 
    BQ636834 BQ272406 CR593097 CR625039 CA419756 BQ549881 CR608665 AV708195 
    BU781880 BI496963 BQ072271 CR617151 BE296713 CR600773 BG282577 BU077574 
    BX428308 BM875604 BQ270751 CR593529 BX334640 CR617238 BM511441 CR621211 
    AI824798 CR593026 CR606891 BM309956 BM565001 BX459999 CA407179 BM764472 
    BU786149 AU142852 CR603635 AU119302 CR596702 CR596240 AA605146 CR456612 
    BQ130708 BQ614641 CK820399 BQ774429 CR614044 F08031 CR614377 BU788064 
    BI094315 BX410648 CR619423 BQ001581 H25293 BU789255 CR615723 AY007132 
    BM460508 AI124697 BU788995 CR601517 H11617 AI470204 BU070050 AI652885 
    CR611926 BQ881925 CR614662 BU782796 CR607383 CR622695 BQ718384 AA322911 
    BX090946 BU947663 AW950283 BX422151 BU786758 AA322961 BU786042 BQ026894 
    AW340648 CR605523 BM800098 BU786742 BU781599 CR600694 CR618980 BX458568 
    CB121832 BU620324 N99662 CR615843 AA262704 BQ424354 BU947249 BM765577 
    CR607325 BM876453 BX430415 BI458375 CD368235 BX428306 BP341182 BX411972 
    CD641276 BQ549947 AW339607 CD106006 BI553495 BX444544 CB155380 BX428307 
    BX325463 AI697089 BQ631080 BM313650 BG676414 AA565955 BX424802 BX407326 
    BX407022 AW274143 BQ187025 N69107 BX409185 BI666601 W16498 BQ614284 
    BG283468 AW274142 BG716112 W61343 BX367495 CD675184 AI811116 R84813 
    BQ108596 BX453371 BI710752 BX333326 N29226 BQ720737 W46595 BX438776 
    BX430638 BI669267 BX428514 BX444527 BU786740 BX461569 BX461039 BX444545 
    BX457573 BQ477302 BX409215 BE888233 BX407430 H21979 AW131665 BX424740 
    AA084101 BX449331 AI523661 AI377985 BU507953 BQ130452 AA322873 AA608688 
    CB112192 BM467808 BM926555 BU069819 BQ000465 CF242796 BI597630 BX451231 
    BM272753 BX414172 BX451230 BQ614437 D54224 AI125315 BX445083 BX445128 
    BX449514 BU632283 BQ581980 AI199076 BX410646 BE881921 BG261356 BX407109 
    AA256774 BX412798 AA700018 BX430475 BX389195 AI359738 BX424741 BX409401 
    BE909424 BX427546 BI765070 BE877957 BM985145 L08439 BQ882105 BX446529 
    BG259939 BX444830 W46596 BI600395 BX451238 BX407442 CA448290 BQ937748 
    BQ549247 BG188026 H25337 BX449337 BQ549730 BX407205 AW170272 BM746236 
    BG939820 BM854775 AI342365 AA724049 AI469689 BM273004 BQ016524 BX433692 
    CD513534 BI711078 BX424640 BX449627 CB132272 BX488634 BQ694777 X78138 
    BM310234 CB955842 BU947929 BX330909 BX409268 BX409400 BG679243 AA343750 
    BX462021 CB997003 BF923383 BX444552 BX346466 BX463844 BU069498 AW602163 
    T28031 W47413 BQ072615 BX454862 BX430446 BX428240 BX418832 BU735417 
    AA909983 AA491574 BP429417 BM792064 H82692 BE783112 BG687334 BI458091 
    NM_003405 BQ436691 BX444528 BM827522 CK005021 BX458567 BX449681 BG874344 
    CB145838 BX461772 BQ614095 BX458220 CB305606 BU616256 AA321827 CD676053 
    BM669503 BP368685 BG777200 BX413831 AI039008 BI869271 AI077943 BX434705 
    BX387144 BX366088 AW956548 BX443124 AA340253 W59944 BX409217 BM763885 
    CK004604 BX352763 BX325309 BU618255 BU071396 BX453372 BX407052 BI603754 
    BX430399 BG714746 CA445638 BM979067 AI089749 AI359337 AV722137 AL537425 
    BX410656 BX407175 BU615434 AI191245 BX407005 BM512401 BX333327 BX428532 
    BQ613833 BX410906 AI082748 BF969152 CK820398 BX407164 BG705941 BI021827 
    BU781596 BQ549706 BG748073 BX440729 AA223241 BM696838 CF618755 BX453370 
    AW340217 AI086877 BQ328374 BX413707 CD676916 AL583492 BQ014583 AA299055 
    CF618754 BI598754 BX325462 BE464590 BM876194 BU070236 BG705953 AA151067 
    BU929972 BX420988 BX418873 N31547 AA361357 BF350700 BX407270 BM510608 
    BI224762 BI667275 AA720684 H67636 BI224443 BX424739 BU521987 W65437 
    AA126874 BX325310 BX377096 BX403926 BU596569 BU069718 BF037999 BM875351 
    BX455649 BX424801 CB155066 BF976019 AA033522 AA305009 AA385288 BX334639 
    BU616641 BX410647 BE814866 BX427545 T11718 BQ303036 AV726024 AI086917 
    BX453193 BU783099 AW799101 X57345 S80794 BI544892 BQ315626 AI248943 
    AV683116 AA864930 AW028427 AV689560 BQ315624 BF104759 BX407178 BI018411 
    BX391125 W94135 AW401377 BI553534 AV727437 BX428460 BF998207 BM824994 
    BI544692 BG002538 AI085941 AI218477 BX445127 BX445140 BM855922 AW383484 
    BU071630 BX407021 BQ310804 BX388313 BM802305 BG105643 AW383504 AU160053 
    AI087141 BQ300360 BX433614 BG714752 AA155615 BG874328 BX424800 BX403072 
    AV698274 BQ315724 BX341148 BF340329 BQ550033 CD558290 BI547668 BQ581651 
    BQ309138 AA629032 AI310394 BX397090 AW799289 BF966138 BX428369 BX449626 
    AL534332 BX417693 BE884042 BG468577 L20422 BG542906 D54950 BF904442 
    H67097 BX420224 BG704479 BE350791 H11706 AI829449 BM794660 BQ315623 
    AA862331 AA156681 BF381178 AA127798 BG708622 H79625 BX409600 BP375269 
    BF954720 BX455352 BF350708 W47608 BE939987 CK024093 N20527 BU677028 
    BE614089 BX428488 BG506219 AL120538 BI600851 BI458109 BG188574 BX449512 
    BQ272370 BX428421 BG980194 BG393010 BQ315627 AA367935 BI603891 BI546644 
    BI552434 BX428607 BX423476 BX428438 AA150830 AA033938 AI352558 AW382095 
    BI550662 BF768011 AA192540 BF823250 AA134368 BF688115 BF834912 BG716294 
    BX410657 CD617074 BE614558 BF846801 BQ300387 AU127209 BI837163 BX428305 
    BI599923 BX421312 AA938406 BE541188 BF951911 BX377095 BE885682 BX449524 
    AI248541 BQ614191 BX409575 T15405 W85826 AA150478 W65436 AW403970 
    BX444551 AI608761 BE538808 BX418334 AA084159 AU077248 BI554008 BX451131 
    BE621334 BE540903 BE540842 N85248 AW998929 W02577 BF935343 BI028364 
    W03139 BX445139 W46459 AI917740 H78021 BQ303037 AW999584 AA740589 
    AI831016 AA249581 H79624 BX465044 AW271187 BE731760 N74377 BF759170 
    BE885276 AU145681 BI910773 BF951840 BQ315725 AI188296 BF947918 BQ777854 
    BF945743 BF882509 AI655561 W85827 CD617072 BE155344 AW835019 CD617073 
    AA988608 W94022 R69901 CD617075 AW799290 BG419548 C03366 AI922133 
    BX449483 BI091029 AW995424 W94127 AA872478 BP429484 BF800387 AA662875 
    BX425112 BX435407 BE002724 AW664539 N79982 CD617077 AI766457 BF816591 
    H69844 W94040 BE960793 AA374252 BC015595 AI811102 BX445082 H60980 
    BX418333 BM809320 CD102372 BG055114 AA487004 BI603662 BX391124 BX465045 
    BX340887 AW383636 AI279782 AA491520 BX410905 AW799105 AA776573 BX421315 
    BX449340 BQ720192 BE155394 AI359620 BQ339540 AA513281 N21530 AI911682 
    BE842983 BE830649 H23204 AW084401 AA192465 BE782494 BF378634 AI261476 
    AW273118 BX442834 BI018331 AI082545 BX442321 BQ308909 AI864305 AI174338 
    CD697641 D82630 AV694829 N74429 AW166100 R82553 BI113912 BX428238 
    N90630 AW900930 BQ300356 AI904207 BQ308898 AI904208 AA033631 AA303717 
    CB996353 AW799109 AW799292 AA171496 R25364 AI421367 BE830609 BX449542 
    BI493502 BF969911 AW799103 BX428333 AW152629 AI866231 CB112861 C21397 
    BX410655 AW799107 H69864 AA219489 BE167441 AW150042 BM922356 AI579932 
    AI554181 AA774536 AI473820 BF945817 AI272249 BX453373 BP347261 AA775958 
    AA908944 BX430734 BX446166 AI635674 BX461826 AV707753 BX430620 BX410907 
    BX449497 H78020 AA223125 AW894663 BX430414 BE170015 AA905196 BU146280 
    AW894624 BF892648 BX449496 AA096126 H13301 AI205606 BX428239 CB995416 
    AA219627 CD617076 H22042 BE826519 BI545389 BQ941537 BI225166 BX449607 
    BX424725 R82499 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAH (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -                                       
    SP2:                    -     -           -     -                                 
    SP3:                    -     -     -     -     -                                 
    SP4:                    -                                                         
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for YWHAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAH expression in normal human tissues (normalized intensities)      YWHAH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATCAAGA
    YWHAH Expression
    About this image


    YWHAH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 25 entries
             Thalamus
             Olfactory Bulb   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             autonomic/sympathetic/ganglion   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             mouse/organ system/cardiovascular system   

    See YWHAH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAH

    SOURCE GeneReport for Unigene cluster: Hs.226755

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels

        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YWHAH
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for YWHAH gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhah1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.22(n)1
    99.19(a)1
      5 (17.42 cM)5
    226291  NM_011738.21  NP_035868.11 
     330188165 
    chicken
    (Gallus gallus)
    Aves YWHAH1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 85.91(n)
    97.97(a)
      416955  NM_001007839.1  NP_001007840.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045230.12   -- 80.56(n)    BC045230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb51h042 Danio rerio cDNA clone MGC63883 IMAGE6789640, complete more 78.49(n)    BC053130.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more
    73(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ftt-26
    par-56
    14-3-3-like protein 1
    73(a)
    73(a)
    many ↔ many
    many ↔ many
    X(11603707-11605421)
    IV(11820505-11821924)


    ENSEMBL Gene Tree for YWHAH (if available)
    TreeFam Gene Tree for YWHAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAH gene
    YWHAE2  YWHAB2  YWHAQ2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAH using alignment to 4 protein entries:     1433F_HUMAN (see all proteins):
    YWHAG    YWHAB    YWHAZ    YWHAQ    SFN    14-3-3 protein
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/232 SNPs in YWHAH are shown (see all 232)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910129111,2
    --32343405(+) CACTTA/GATAAT 1 -- int10--------
    rs1831334371,2
    --32343452(+) CCAGCA/GTCACC 1 -- int10--------
    rs762705741,2
    C--32343478(+) GTAAGA/CTTGAA 1 -- int10--------
    rs1883118861,2
    C--32343508(+) AAACAA/GTGGTC 1 -- int10--------
    rs106317881,2
    C--32343613(+) TCAAGCTCT/-  
            
    CTCTA
    1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs343249181,2
    C--32343614(+) CAAGC-/CTCT  
            
    TCTAT
    1 -- int10--------
    rs1498527091,2
    C--32343662(+) AAGAAA/GTATTG 1 -- int10--------
    rs1466569501,2
    --32343680(+) TTCTAC/GAACCT 1 -- int10--------
    rs738842431,2
    C,F--32343831(+) ACCAGA/GTAGAT 1 -- int13Minor allele frequency- G:0.05WA NA 240
    rs9332261,2
    C,F,O,A,H--32343847(+) GTGGAT/CATTCA 1 -- int122Minor allele frequency- C:0.11EA NA MN NS 1606

    HapMap Linkage Disequilibrium report for YWHAH (32340447 - 32353590 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAH:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508731CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAH
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 113508    OMIM disorders: --

    15 diseases for YWHAH:    About MalaCards
    early-onset schizophrenia    bipolar disorder    schizophrenia    lipodystrophy
    sporadic breast cancer    insulin resistance    parkinson's disease    alcoholism
    multiple sclerosis    myeloid leukemia    squamous cell carcinoma    breast cancer
    leukemia    endotheliitis    neuronitis


    YWHAH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for YWHAH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 2 10206237 (1), 11121172 (1)
    tumors 0 1 1578511 (1)

    Genetic Association Database (GAD): YWHAH
    Human Genome Epidemiology (HuGE) Navigator: YWHAH (4 documents)

    Export disorders for YWHAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAH gene, integrated from 9 sources (see all 145):
    (articles sorted by number of sources associating them with YWHAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain. (PubMed id 1578511)1, 2, 9 Ichimura-Ohshima Y.... Kuwano R. (1992)
    2. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. (PubMed id 8218406)1, 2, 9 Swanson K.D.... Joshi J.G. (1993)
    3. 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia. (PubMed id 10206237)1, 4, 9 Toyooka K....Takahashi Y. (1999)
    4. Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia. (PubMed id 11121172)1, 4, 9 Bell R....Collier D.A. (2000)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    6. Family-based association of YWHAH in psychotic bipolar disorder. (PubMed id 19160447)1, 4 Grover D....Potash J.B. (2009)
    7. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    8. [Association study between NPY and YWHAH gene polymorphisms and schizophrenia] (PubMed id 16459651)1, 4 Wang H.S....He L. (2005)
    9. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7533 HGNC: 12853 AceView: YWHAH Ensembl:ENSG00000128245 euGenes: HUgn7533
    ECgene: YWHAH Kegg: 7533 H-InvDB: YWHAH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for YWHAH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YWHAH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for YWHAH gene:
    Search GeneIP for patents involving YWHAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for YWHAH (14-3-3 eta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for YWHAH  
     OriGene qPCR primer pairs and template standards for YWHAH   OriGene Protein Over-expression Lysate for YWHAH  
     OriGene MassSpec something-or-other for YWHAH   OriGene clones in human, mouse for YWHAH  
     OriGene qSTAR qPCR primer pairs in human, mouse for YWHAH   OriGene Purified Protein for YWHAH  
     OriGene ORF clones in mouse, rat for YWHAH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for YWHAH   OriGene Custom Protein Services for YWHAH  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat YWHAH
     QIAGEN SeqTarget long-range PCR primers for resequencing YWHAH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat YWHAH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
     GenScript Custom Purified and Recombinant Proteins Services for YWHAH GenScript cDNA clones with any tag delivered in your preferred vector for YWHAH
     GenScript Custom Assay Services for YWHAH GenScript Custom Superior Antibodies Services for YWHAH
     GenScript Custom overexpressing Cell Line Services for YWHAH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for YWHAH 
    (14-3-3 eta)

     Regulatory tfbs in YWHAH promoter
     Search Chromatin IP Primers for YWHAH
     RT2 qPCR Primer Assay in human, mouse, rat YWHAH
     GNC Network for YWHAH
     SABiosciences PCR Arrays including human, mouse, rat YWHAH
     Tocris compounds for YWHAH
     Proteins and Antibodies for YWHAH
     Browse Sino Biological Cell Lysates
     cDNA Clones for YWHAH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for YWHAH
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     YWHAH antibodies
     YWHAH proteins
     YWHAH lysates
     Antibodies for YWHAH
     See all of Abcam's Antibodies, Kits and Proteins for YWHAH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for YWHAH




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for YWHAH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH
     SwitchGear 3'UTR luciferase reporter plasmids for YWHAH
     SwitchGear Promoter luciferase reporter plasmids for YWHAH
     ThermoFisher Antibodies for YWHAH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH
     inGenious Targeting Laboratory - Custom generated mouse model solutions for YWHAH
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for YWHAH
    Customized:
     lentivirus for stable overexpression of YWHAH
     lentivirus expression plasmids for stable overexpression of YWHAH
     adenovirus for overexpression of YWHAH
     LSBio Antibodies in human, mouse, rat for YWHAH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
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