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YWHAH Gene

protein-coding   GIFtS: 70
GCID: GC22P032340

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHA1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Eta1 2
YWHA11 2 3 5
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Eta Polypeptide1 2
14-3-3 Eta1 2
14-3-3 Protein Eta2
Protein AS13

External Ids:    HGNC: 128531   Entrez Gene: 75332   Ensembl: ENSG000001282457   OMIM: 1135085   UniProtKB: Q049173   
ORGUL members:         

Export aliases for YWHAH gene to outside databases

Previous GC identifers: GC22P029036 GC22P030665 GC22P015296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for YWHAH Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence
in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and
psychotic bipolar disorder. (provided by RefSeq, Jun 2009)

GeneCards Summary for YWHAH Gene:
YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta) is a protein-coding gene. Diseases associated with YWHAH include early-onset schizophrenia, and bipolar disorder. GO annotations related to this gene include enzyme binding and protein heterodimerization activity. An important paralog of this gene is YWHAE.

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAH Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAH gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAH promoter sequence
   Search Chromatin IP Primers for YWHAH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.1-q13.1

YWHAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAH gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P032340:  view genomic region     (about GC identifiers)

Start:
32,340,447 bp from pter      End:
32,353,590 bp from pter
Size:
13,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917 (See protein sequence)
Recommended Name: 14-3-3 protein eta  
Size: 246 amino acids; 28219 Da
Subunit: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR,
ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction
retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B.
Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By
similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1
2 PDB 3D structures from and Proteopedia for YWHAH:
2C63 (3D)        2C74 (3D)    

Explore the universe of human proteins at neXtProt for YWHAH: NX_Q04917

Explore proteomics data for YWHAH at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By
    similarity)1
  • Ubiquitination2 at Lys50, Lys69, Lys110, Lys125, Lys127
  • Modification sites at PhosphoSitePlus

  • See YWHAH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003396.1  
    ENSEMBL proteins: 
     ENSP00000248975   ENSP00000408468   ENSP00000380629   ENSP00000406747  
    Reactome Protein details: Q04917

    YWHAH Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for YWHAH
    OriGene MassSpec for YWHAH
    OriGene Custom Protein Services for YWHAH
    GenScript Custom Purified and Recombinant Proteins Services for YWHAH
    Novus Biologicals YWHAH Proteins
    Novus Biologicals YWHAH Lysate
    Sino Biological Recombinant Protein for YWHAH
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for YWHAH
    Browse Proteins at Cloud-Clone Corp.

    YWHAH Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
    R&D Systems Antibodies for YWHAH (14-3-3 eta)
    Cell Signaling Technology (CST) Antibodies for YWHAH  (14-3-3 eta)
    OriGene Antibodies for YWHAH
    OriGene Custom Antibody Services for YWHAH
    Novus Biologicals YWHAH Antibodies
    Abcam antibodies for YWHAH
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for YWHAH
    LSBio Antibodies in human, mouse, rat for YWHAH

    YWHAH Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YWHAH
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry Q04917

    ProtoNet protein and cluster: Q04917

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Similarity: Belongs to the 14-3-3 family


    YWHAH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433F_HUMAN, Q04917
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAH:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 eta protein,multifunctional regulator
    involved in cell-cyle control (checkpoint), and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005159insulin-like growth factor receptor binding ISS--
    GO:0005515protein binding IPI10713667
    GO:0017080sodium channel regulator activity IDA16728661
    GO:0019899enzyme binding IPI17255105
         
    YWHAH for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ywhah (no phenotypes)

    YWHAH for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YWHAH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YWHAH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YWHAH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YWHAH

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAH:
    hsa-mir-186-5p (MIRT021116), hsa-mir-16-5p (MIRT032075), hsa-mir-32-5p (MIRT028327), hsa-mir-103a-3p (MIRT027235), hsa-mir-324-5p (MIRT043064), hsa-mir-33a-5p (MIRT028247)

    Block miRNA regulation of human, mouse, rat YWHAH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YWHAH
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YWHAH

    Clone
    Products:
         
    OriGene clones in human, mouse for YWHAH (see all 6)
    OriGene ORF clones in mouse, rat for YWHAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
    Sino Biological Human cDNA Clone for YWHAH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for YWHAH
    Browse ESI BIO Cell Lines and PureStem Progenitors for YWHAH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA16728661
    GO:0014704intercalated disc IC16728661
    GO:0030659cytoplasmic vesicle membrane TAS--

    YWHAH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for YWHAH About   (see all 46)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BAD and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAH
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAH (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAH
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAH
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAH
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for YWHAH (see all 18)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Alpha6-Beta4 Integrin Signaling Pathway


    2 Reactome Pathways for YWHAH
        Activation of BAD and translocation to mitochondria
    Translocation of GLUT4 to the plasma membrane


    Selected Kegg Pathways  (Kegg details for YWHAH) (see all 6):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Epstein-Barr virus infection


    YWHAH for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YWHAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAH (Q049171, 2, 3 ENSP000002489754) via UniProtKB, MINT, STRING, and/or I2D (see all 480)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25BP303051, 2, 3, ENSP000002459604EBI-306940,EBI-1051746 MINT-8007505 MINT-25118 MINT-19328 MINT-19330 I2D: score=4 STRING: ENSP00000245960
    HDAC4P565241, 2, 3, ENSP000002646064EBI-306940,EBI-308629 MINT-8008113 I2D: score=2 STRING: ENSP00000264606
    YWHAQP273482, 3, ENSP000002380814MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000238081
    PTH1RQ034312, 3, ENSP000003219994MINT-15642 MINT-15641 MINT-5207093 I2D: score=2 STRING: ENSP00000321999
    YWHAEP622582, 3, ENSP000002643354MINT-7300139 MINT-7899812 I2D: score=6 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002028regulation of sodium ion transport IDA16728661
    GO:0006713glucocorticoid catabolic process IDA15790729
    GO:0006886intracellular protein transport ISS--
    GO:0006915apoptotic process TAS--
    GO:0021762substantia nigra development IEP--

    YWHAH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for YWHAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    1 Novoseek inferred chemical compound relationship for YWHAH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.8 1 16545136 (1)



    YWHAH for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for YWHAH gene: 
    NM_003405.3  

    Unigene Cluster for YWHAH:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
    Hs.226755  [show with all ESTs]
    Unigene Representative Sequence: NM_003405
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248975(uc003alz.3) ENST00000443669 ENST00000397492 ENST00000479649
    ENST00000471374(uc003ama.3 uc010gwm.3) ENST00000420430
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat YWHAH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAH 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
      QuantiFast Probe-based Assays in human, mouse, rat YWHAH

    Additional mRNA sequence: 

    AK307750.1 AK312650.1 AY007132.1 BC003047.1 CR456612.1 L08439.1 L20422.1 S80794.1 
    X57345.1 X78138.1 

    Selected DOTS entries (see all 36):

    DT.95111929  DT.448876  DT.101976744  DT.100711364  DT.407748  DT.120670119  DT.91783556  DT.100851802 
    DT.100700123  DT.100637903  DT.97771863  DT.120670168  DT.95109036  DT.99965707  DT.100733502  DT.100847487 
    DT.100852063  DT.92342680  DT.100637738  DT.100647593  DT.100650467  DT.100647591  DT.100659038  DT.100662630 

    810 AceView cDNA sequences (see top 24):

    CA407179 BU196763 BQ130708 BQ267143 CA397229 BM764472 CR603635 AU119302 
    BM765261 CR596702 F04963 CR596240 BU170128 AA605146 AI423963 BQ787495 
    BQ072030 BU786149 CR624998 CR456612 BU947953 AU142852 H11617 AI470204 
    BU070050 AI652885 CR611926 BM309956 BX459999 BM565001 CR606891 CR593026 
    AI824798 CR619423 BQ001581 H25293 BU789255 BQ614641 CK820399 BQ774429 
    CR614044 F08031 CR614377 BU788064 BI094315 BU783553 CR617238 BQ636834 
    BU947358 BX397091 AV708195 BQ549222 BQ272406 BQ267763 BU152865 CR600773 
    CR617151 BQ424354 BM875604 BU677803 BI496963 CR608665 CR593097 BE888276 
    BU784398 CR593529 BU077574 BE296713 BX421313 BQ937845 BX428308 BQ270511 
    BQ270751 CR621211 CR618712 BM876453 BX430121 CA419756 BM019303 BU781880 
    BM511441 BQ879509 AA505883 BQ424474 BQ549881 BX334640 BG282577 BQ072271 
    CR622989 AL120082 BC003047 CA448024 BM557627 BF592036 R69858 CA416908 
    BM766007 CR611605 AI083995 AA304626 BU070776 BM741105 BM313913 N71711 
    BM762239 BX443473 CR602331 CR600337 CK300088 AI089839 BU783343 BX417694 
    BQ000356 CR615843 N99662 BU620324 CB121832 BX458568 CR618980 CR600694 
    BU781599 BU786742 BM800098 CR605523 AW340648 BQ026894 BU786042 AA322961 
    BU786758 BX422151 AW950283 BU947663 BX090946 AA322911 BQ718384 CR622695 
    CR607383 BU782796 CR614662 BQ881925 CR601517 BU788995 AI124697 BM460508 
    AY007132 CR615723 CR616670 AA262704 BU070540 CR607325 BX410648 BM765577 
    BU947249 CR625039 W61343 AW274142 CF242796 BX451231 BF037999 BX462021 
    BI597630 BM926555 N69107 BM827522 BM875351 CB155380 BQ436691 BI458091 
    BP341182 BX449514 AI199076 NM_003405 BX428306 H82692 BU069498 BX463844 
    BX444552 BF923383 BX428240 BX430446 BX409215 BG687334 AA909983 BX414172 
    BI669267 BX454862 BM467808 BQ072615 BU735417 BX445128 AW274143 BE881921 
    BX407326 BX407430 BX407022 BP429417 BM792064 BX346466 BQ631080 BX444528 
    BE783112 AA491574 BX333326 AI125315 W47413 T28031 AW602163 N29226 
    BX418832 BX352763 BX325309 BU618255 BU071396 BX453372 BX407052 BI603754 
    BX430399 BG714746 CA445638 BM979067 AI089749 AI359337 AV722137 AL537425 
    BX410656 BX407175 BU615434 BG679243 AA343750 BX409400 BX409268 BX330909 
    CD676053 BM669503 CK005021 BX458567 BX449681 BG874344 CB145838 BX461772 
    BQ614095 BX458220 CB305606 BU616256 AA321827 BP368685 BG777200 BX413831 
    AI039008 BI869271 BM313650 CD513534 CD641276 BX451230 BX453371 BQ477302 
    BU632283 BE814866 CD368235 BX428514 BM746236 AW131665 BU069819 BX430415 
    AI523661 BX433692 CA448290 BG261356 BX325463 BI710752 AA608688 BF976019 
    BX444544 AI377985 BI600395 BG188026 AI697089 BM310234 BX334639 AA724049 
    BX411972 BU616641 BU786740 BQ549947 BX424640 BM854775 BX424802 BX461039 
    AW339607 BQ549730 BX367495 AA033522 AA322873 H21979 BX445083 BI711078 
    BX449331 BX457573 BX407205 BX444545 BX438776 AA084101 CB132272 CB955842 
    AI811116 BU507953 BQ937748 AA385288 BX424740 BQ720737 BX410646 BX488634 
    CD106006 BI553495 AA305009 BG676414 BX451238 BG939820 D54224 BX428307 
    AI469689 BQ694777 BE888233 H25337 BQ016524 AI342365 BX407442 W46596 
    BX444830 BG259939 BX446529 BQ882105 L08439 BM985145 BE877957 BI765070 
    BX427546 BE909424 BX409401 BX424741 AI359738 BX389195 BX430475 AA700018 
    BX412798 AA256774 BX407109 BX430638 R84813 BQ000465 W46595 CB155066 
    BX449337 BU947929 BX410647 BQ581980 BI458375 CD675184 BQ549247 BX449627 
    BX444527 BM273004 AW170272 BU596569 BX403926 BX377096 BX325310 AA126874 
    W65437 BU521987 BX424739 BI224443 H67636 AA720684 BI667275 BI224762 
    BM510608 BX407270 BF350700 AA361357 N31547 BX418873 BX420988 BU929972 
    AA151067 BG705953 BU070236 BM876194 BE464590 BX325462 BI598754 CF618754 
    AA299055 BQ014583 AL583492 CD676916 BX413707 BQ328374 AI086877 AW340217 
    BX453370 CF618755 BM696838 AA223241 BX440729 BG748073 BQ549706 BU781596 
    BI021827 BG705941 BX407164 CK820398 BF969152 AI082748 BX410906 BQ613833 
    BX428532 BX333327 BM512401 BX407005 AI191245 CK004604 BM763885 BX409217 
    W59944 AA340253 BX443124 AW956548 BX366088 BX387144 BX434705 AI077943 
    BI666601 BX409185 BQ614284 BU069718 BX455649 W16498 BM272753 BG716112 
    CB997003 BG283468 BQ187025 BX424801 BQ108596 BQ614437 CB112192 BX461569 
    X78138 BQ130452 AA565955 BI553534 D54950 BX445127 AI085941 BG002538 
    AV683116 BU783099 BG704479 BQ303036 S80794 H67097 BX391125 BI018411 
    BX420224 BG542906 BF104759 BX427545 BX407178 BF904442 BQ315624 BX428607 
    BX455352 BF350708 W47608 BE939987 CK024093 L20422 BG468577 BE884042 
    BF381178 AA127798 BE350791 H11706 AI829449 BM794660 BQ315623 AA862331 
    W94135 BG874328 AI218477 AW799101 AV698274 BX445140 BX423476 AI310394 
    BU071630 AV727437 AA155615 BM824994 T11718 BF998207 BQ315724 BX428460 
    BI547668 BX453193 BG714752 BQ309138 BX403072 BM855922 AI086917 BX428369 
    BQ300360 BX424800 BX397090 BX417693 AA629032 X57345 AW799289 BF966138 
    AV726024 AW028427 BQ550033 AV689560 AI087141 AU160053 AW383504 BG105643 
    BM802305 BX388313 BQ310804 BX433614 AW383484 AW401377 BQ581651 BX341148 
    BX407021 BX449626 CD558290 AL534332 BI603891 AA367935 BQ315627 BG393010 
    BG980194 BX428421 BQ272370 BX449512 BG188574 BI458109 BI600851 AL120538 
    BG506219 BX428488 BE614089 BU677028 N20527 BF954720 BP375269 BX409600 
    H79625 BG708622 AI248943 AA864930 BI546644 BI544692 BI552434 BQ315626 
    BI544892 AA156681 BF340329 AW382095 BF882509 AA938406 BX428438 CD617072 
    BX421312 N85248 AA150830 AW998929 AA033938 BX428305 BI599923 BF688115 
    AW999584 BE540842 BE540903 BX445139 W46459 W02577 BF935343 BI028364 
    W03139 AI917740 AI352558 CD617074 AA084159 AI608761 BX410657 BE621334 
    BF823250 BI550662 BX444551 W85827 AA150478 AI655561 W65436 BF951911 
    BG716294 BF846801 BI837163 AU077248 BI554008 BE538808 BX451131 BF834912 
    AU127209 AA134368 BX418334 W85826 T15405 BX409575 BQ614191 AI248541 
    BX449524 BE885682 BX377095 AW403970 BE614558 BQ300387 BF945743 BQ777854 
    BF947918 AI188296 BQ315725 BF951840 BI910773 AU145681 BE885276 BF759170 
    N74377 BE731760 AW271187 BX465044 H79624 AA249581 AI831016 AA740589 
    BQ303037 H78021 BF768011 AA192540 BE541188 BG419548 W94022 AW799290 
    BG055114 C03366 CD102372 BE155344 CD617073 AA487004 BE830649 BX410905 
    AW799105 AA776573 BX421315 BX391124 BX465045 BI603662 CD617075 BE842983 
    BI091029 AW835019 AA872478 AA662875 BM809320 W94127 BE960793 BC015595 
    BP429484 BX418333 AI922133 BE002724 BF800387 R69901 BX449483 AW995424 
    AA988608 AA374252 BX445082 W94040 H69844 BF816591 AI766457 CD617077 
    N79982 BX435407 AI811102 H60980 BX425112 AI911682 N21530 AA513281 
    BQ339540 AI359620 BE155394 BQ720192 BX449340 AA491520 AI279782 AW383636 
    BX340887 AW664539 BQ300356 AI864305 BQ308909 BQ308898 H23204 AI904207 
    AA192465 AI082545 AW084401 AI174338 CB996353 AW900930 AI904208 N90630 
    BI493502 BX442834 AW273118 BX442321 BE782494 BX428238 BI018331 AI261476 
    R82553 AW166100 N74429 AV694829 D82630 CD697641 BF378634 BX449542 
    BE830609 AI421367 R25364 AA171496 AW799292 AW799109 AA303717 AA033631 
    BI113912 BE167441 BX453373 C21397 AA775958 BX410655 AW150042 AI272249 
    H69864 BP347261 CB112861 AW799103 AW152629 AI635674 BF945817 AA908944 
    AW799107 AA219489 BM922356 BF969911 AI579932 AA223125 AI473820 AI554181 
    AI866231 AA774536 H78020 BX449497 BX410907 BX430620 AV707753 BX461826 
    BX446166 BX430734 BX428333 BX449496 AW894624 BF892648 AW894663 H13301 
    AI205606 AA096126 BX430414 AA905196 BU146280 BE170015 CD617076 AA219627 
    CB995416 BX428239 BE826519 BX449607 BQ941537 BI225166 H22042 R82499 
    BX424725 BI545389 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YWHAH (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -                                       
    SP2:                    -     -           -     -                                 
    SP3:                    -     -     -     -     -                                 
    SP4:                    -                                                         
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for YWHAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    YWHAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATCAAGA
    YWHAH Expression
    About this image


    YWHAH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
    YWHAH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.226755

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YWHAH
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YWHAH
    QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
    QuantiFast Probe-based Assays in human, mouse, rat YWHAH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for YWHAH gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhah1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.22(n)1
    99.19(a)1
      5 (17.42 cM)5
    226291  NM_011738.21  NP_035868.11 
     330188165 
    chicken
    (Gallus gallus)
    Aves YWHAH1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 85.91(n)
    97.97(a)
      416955  NM_001007839.1  NP_001007840.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    2(118187473-118188219)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045230.12   -- 80.56(n)    BC045230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb51h042 Danio rerio cDNA clone MGC63883 IMAGE6789640, complete more 78.49(n)    BC053130.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M117.36
    Protein M117.3 (M117.3) mRNA, complete cds
    38(a)
    1 → many
    IV(11823371-11823938) WBGene00010919
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BMH16
    BMH26
    14-3-3 protein, major isoform; controls proteome a...
    14-3-3 protein, minor isoform; controls proteome a...
    56(a)
    55(a)
    many ↔ many
    many ↔ many
    V(545611-546414) YER177W
    IV(653607-654428) YDR099W


    ENSEMBL Gene Tree for YWHAH (if available)
    TreeFam Gene Tree for YWHAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for YWHAH gene
    YWHAE2  YWHAB2  YWHAQ2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAH using alignment to 4 protein entries:     1433F_HUMAN (see all proteins):
    YWHAG    YWHAB    YWHAZ    YWHAQ    SFN    14-3-3 protein
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for YWHAH (see all 232)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910129111,2
    --32343405(+) CACTTA/GATAAT 1 -- int10--------
    rs1831334371,2
    --32343452(+) CCAGCA/GTCACC 1 -- int10--------
    rs762705741,2
    C--32343478(+) GTAAGA/CTTGAA 1 -- int10--------
    rs1883118861,2
    C--32343508(+) AAACAA/GTGGTC 1 -- int10--------
    rs106317881,2
    C--32343613(+) TCAAGCTCT/-  
            
    CTCTA
    1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs343249181,2
    C--32343614(+) CAAGC-/CTCT  
            
    TCTAT
    1 -- int10--------
    rs1498527091,2
    C--32343662(+) AAGAAA/GTATTG 1 -- int10--------
    rs1466569501,2
    --32343680(+) TTCTAC/GAACCT 1 -- int10--------
    rs738842431,2
    C,F--32343831(+) ACCAGA/GTAGAT 1 -- int13Minor allele frequency- G:0.05WA NA 240
    rs9332261,2
    C,F,O,A,H--32343847(+) GTGGAT/CATTCA 1 -- int122Minor allele frequency- C:0.11EA NA MN NS 1606

    HapMap Linkage Disequilibrium report for YWHAH (32340447 - 32353590 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508731CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAH
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 113508    OMIM disorders: --

    18 diseases for YWHAH:    
    About MalaCards
    early-onset schizophrenia    bipolar disorder    schizophrenia    sporadic breast cancer
    lipodystrophy    insulin resistance    parkinson's disease    meningioma
    multiple sclerosis    myeloid leukemia    hiv-1    breast cancer
    squamous cell carcinoma    cervicitis    leukemia    endotheliitis
    cerebritis    neuronitis


    YWHAH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for YWHAH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 2 10206237 (1), 11121172 (1)
    tumors 0 1 1578511 (1)

    Genetic Association Database (GAD): YWHAH
    Human Genome Epidemiology (HuGE) Navigator: YWHAH (4 documents)

    Export disorders for YWHAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for YWHAH gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with YWHAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain. (PubMed id 1578511)1, 2, 9 Ichimura-Ohshima Y.... Kuwano R. (J. Neurosci. Res. 1992)
    2. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. (PubMed id 8218406)1, 2, 9 Swanson K.D.... Joshi J.G. (Biochim. Biophys. Acta 1993)
    3. 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia. (PubMed id 10206237)1, 4, 9 Toyooka K....Takahashi Y. (Am. J. Med. Genet. 1999)
    4. Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia. (PubMed id 11121172)1, 4, 9 Bell R....Collier D.A. (Am. J. Med. Genet. 2000)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    6. Family-based association of YWHAH in psychotic bipolar disorder. (PubMed id 19160447)1, 4 Grover D....Potash J.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    8. [Association study between NPY and YWHAH gene polymorphisms and schizophrenia]. (PubMed id 16459651)1, 4 Wang H.S....He L. (Yi Chuan Xue Bao 2005)
    9. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (Nat. Cell Biol. 2005)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7533 HGNC: 12853 AceView: YWHAH Ensembl:ENSG00000128245 euGenes: HUgn7533
    ECgene: YWHAH Kegg: 7533 H-InvDB: YWHAH

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for YWHAH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YWHAH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for YWHAH gene:
    Search GeneIP for patents involving YWHAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    (14-3-3 eta)

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Browse ESI BIO Cell Lines and PureStem Progenitors for YWHAH
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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