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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

YWHAH Gene

protein-coding   GIFtS: 65
GCID: GC22P032340

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...


(Previous symbol: YWHA1)
 Explore 15 diseases affiliated with
YWHAH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for YWHAH    

Aliases
for YWHAH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Eta
Polypeptide1 2
YWHA11 2 3 5
14-3-3 Eta2
14-3-3 Protein Eta2
Protein AS13

External Ids:    HGNC: 128531   Entrez Gene: 75332   Ensembl: ENSG000001282457   OMIM: 1135085   UniProtKB: Q049173   
ORGUL members:         

Export aliases for YWHAH gene to outside databases

Previous GC identifers: GC22P029036 GC22P030665 GC22P015296


Summaries
for YWHAH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for YWHAH:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this
protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5'
UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic
bipolar disorder. (provided by RefSeq, Jun 2009)

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase
activity of PDPK1

summary for YWHAH:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAH


Genomic Views
for YWHAH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the YWHAH gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAH promoter sequence
   Search SABiosciences Chromatin IP Primers for YWHAH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat YWHAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.1-q13.1

YWHAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAH gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P032340:  view genomic region     (about GC identifiers)

Start:
 32,340,447 bp from pter      End:
 32,353,590 bp from pter
Size:
 13,144 bases      Orientation:
 plus strand

Proteins
for YWHAH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917 (See protein sequence)
Recommended Name: 14-3-3 protein eta  
Size: 246 amino acids; 28219 Da
Subunit: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1,
ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in
the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2.
Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the
'Ser-241' phosphorylated form of PDPK1
2 PDB 3D structures from and Proteopedia for YWHAH:
2C63 (3D)        2C74 (3D)    

Explore the universe of human proteins at neXtProt for YWHAH: NX_Q04917

Post-translational modifications:

  • Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By
    • similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04917

    • YWHAH Protein expression data from MOPED and PaxDb:    About this image 
    YWHAH Protein Expression
    REFSEQ proteins: NP_003396.1  
    ENSEMBL proteins: 
     ENSP00000248975   ENSP00000408468   ENSP00000380629   ENSP00000406747  
    Reactome Protein details: Q04917
    Human Recombinant Protein Products for YWHAH: 
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    ProSpec Recombinant Protein for YWHAH
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0014704intercalated disc IC16728661

    YWHAH for ontologies           About GeneDecksing



    YWHAH Antibody Products: 
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    Protein Domains /
    Families
    for YWHAH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    YWHAH for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023410 14-3-3_domain
     IPR000308 14-3-3
     IPR023409 14-3-3_CS

    Graphical View of Domain Structure for InterPro Entry Q04917

    ProtoNet protein and cluster: Q04917

    1 Blocks protein family: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Similarity: Belongs to the 14-3-3 family


    Function
    for YWHAH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433F_HUMAN, Q04917
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling
    pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.
    Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase
    activity of PDPK1

         Genatlas biochemistry entry for YWHAH:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 eta protein,multifunctional regulator
    involved in cell-cyle control (checkpoint), and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004497monooxygenase activity ----
    GO:0005159insulin-like growth factor receptor binding ISS--
    GO:0005515protein binding IPI--
    GO:0017080sodium channel regulator activity ISS--
         
    YWHAH for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ywhah (no phenotypes)

    YWHAH for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for YWHAH 

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: YWHAH 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for YWHAH (see all 7)
    OriGene shRNA RFP: YWHAH
    OriGene siRNA: YWHAH
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    Sirion Biotech Custom design and validation of potent shRNA sequences against YWHAH 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of YWHAH 
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    Clone
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for YWHAH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		Activation of PKA through GPCR0.71
    		cAMP Pathway0.77
    		PKA Signaling0.56
    2Apoptosis and survival BAD phosphorylation
    		Apoptosis and survival BAD phosphorylation1.00
    		BAD Phosphorylation0.41
    		Apoptosis and survival_BAD phosphorylation0.99
    3Cell cycle_Role of 14-3-3 proteins in cell cycle regulation
    		Cell cycle_Role of 14-3-3 proteins in cell cycle regulation1.00
    		14-3-3 and Cell Cycle Regulation0.45
    		Cell cycle Role of 14-3-3 proteins in cell cycle regulation1.00
    4BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    		Activation of BH3-only proteins0.30
    		Activation of BAD and translocation to mitochondria 0.15
    		Intrinsic Pathway for Apoptosis0.23
    5Immune response_Function of MEF2 in T lymphocytes
    		Immune response_Function of MEF2 in T lymphocytes1.00
    		Immune response Function of MEF2 in T lymphocytes0.90

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for YWHAH
        Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Apoptosis and survival BAD phosphorylation

    1 R&D Systems Pathway for YWHAH
        Apoptosis Signaling Pathways

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for YWHAH (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAH
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAH
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAH
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/17 BioSystems Pathways for YWHAH (see all 17) 
        Myometrial Relaxation and Contraction Pathways
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    TNF-alpha/NF-kB Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway

    5/6        Reactome Pathways for YWHAH (see all 6)
        Activation of BH3-only proteins
    Activation of BAD and translocation to mitochondria
    Intrinsic Pathway for Apoptosis
    Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane


    3         Kegg Pathways  (Kegg details for YWHAH):
        Cell cycle
    Oocyte meiosis
    Neurotrophin signaling pathway


    YWHAH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for YWHAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/380 Interacting proteins for YWHAH (Q049171, 2, 3 ENSP000002489754) via UniProtKB, MINT, STRING, and/or I2D (see all 380)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK2Q7KZI71, 2, 3, ENSP000003891844EBI-306940,EBI-516560 MINT-8009011 MINT-8009018 I2D: score=3 STRING: ENSP00000389184
    GREM1O605651, 2, 3, ENSP000003001774EBI-306940,EBI-944395 MINT-8007394 I2D: score=4 STRING: ENSP00000300177
    YWHAGP619812, 3, ENSP000003063304MINT-7300139 MINT-6542674 MINT-7264099 MINT-7899812 I2D: score=2 STRING: ENSP00000306330
    YWHAQP273482, 3, ENSP000002380814MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000238081
    YWHAEP622582, 3, ENSP000002643354MINT-7300139 MINT-7899812 I2D: score=6 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002028regulation of sodium ion transport ISS--
    GO:0006713glucocorticoid catabolic process IDA15790729
    GO:0006886intracellular protein transport ISS--
    GO:0042921glucocorticoid receptor signaling pathway IDA15790729
    GO:0045664regulation of neuron differentiation ISS--

    YWHAH for ontologies           About GeneDecksing



    Drugs & Compounds
    for YWHAH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    YWHAH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for YWHAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]
    1 Novoseek chemical compound relationship for YWHAH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.8 1 16545136 (1)

    Search CenterWatch for drugs/clinical trials and news about YWHAH / 1433F 

    Transcripts
    for YWHAH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for YWHAH gene: 
    NM_003405.3  

    Unigene Cluster for YWHAH:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
    Hs.226755  [show with all ESTs]
    Unigene Representative Sequence: NM_003405
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248975(uc003alz.3) ENST00000443669 ENST00000397492 ENST00000479649
    ENST00000471374(uc003ama.3 uc010gwm.3) ENST00000485296 ENST00000420430


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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
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    Additional cDNA sequence: 

    AK307750.1 AK312650.1 AY007132.1 BC003047.1 CR456612.1 L08439.1 L20422.1 S80794.1 
    X57345.1 X78138.1 

    24/36 DOTS entries (see all 36):

    DT.95111929  DT.448876  DT.101976744  DT.100711364  DT.407748  DT.120670119  DT.91783556  DT.100851802 
    DT.100700123  DT.100637903  DT.97771863  DT.120670168  DT.95109036  DT.99965707  DT.100733502  DT.100847487 
    DT.100852063  DT.92342680  DT.100637738  DT.100647593  DT.100650467  DT.100647591  DT.100659038  DT.100662630 

    24/810 AceView cDNA sequences (see all 810):

    BQ549222 BQ937845 BU152865 BQ879509 AL120082 BX417694 AI089839 CR622989 
    BQ000356 BX397091 BU677803 BU783343 BQ267763 BX430121 BE888276 BM876453 
    BQ270511 BU947249 CR618712 AA505883 BC003047 BQ424474 BQ424354 BX421313 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAH (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -                                       
    SP2:                    -     -           -     -                                 
    SP3:                    -     -     -     -     -                                 
    SP4:                    -                                                         
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for YWHAH

    Expression
    for YWHAH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    YWHAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAATCAAGA
    YWHAH Expression
    About this image
    See YWHAH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for YWHAH

    SOURCE GeneReport for Unigene cluster: Hs.226755

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels

        SABiosciences Expression via Pathway-Focused PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for YWHAH
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat YWHAH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat YWHAH
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for YWHAH

    Orthologs
    for YWHAH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for YWHAH gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves YWHAH1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 85.91(n)
    97.97(a)    		   416955  NM_001007839.1  NP_001007840.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC045230.12   -- 80.56(n)    BC045230.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb51h042 Danio rerio cDNA clone MGC63883 IMAGE6789640, complete more 78.49(n)    BC053130.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta 14-3-3&zgr;3 RAS protein signal transduction
    diacylglycerol-activated/phospholipid
    more    		 73(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ftt-26
    par-56
    (see all 3)    		 14-3-3-like protein 1
    (see all 3)    		 74(a)
    73(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 X(11603640-11605354)
    IV(11820482-11821901)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons 14-3-3EPSILON6
    GRF36
    (see all 14)    		 14-3-3-like protein GF14 psi
    (see all 14)    		 57(a)
    57(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 1(7878769-7881219)
    5(15409697-15411516)
    rice
    (Oryza sativa)    		 Liliopsida GF14c6
    GF14f6
    (see all 8)    		 14-3-3 protein, putative, expressed
    (see all 8)    		 56(a)
    55(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 8(20809790-20812919)
    3(28656820-28661023)


    ENSEMBL Gene Tree for YWHAH (if available)
    TreeFam Gene Tree for YWHAH (if available) 

    Paralogs
    for YWHAH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for YWHAH gene
    YWHAE2  YWHAQ2  YWHAB2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAH using alignment to 4 protein entries:     1433F_HUMAN (see all proteins):
    YWHAG    YWHAB    YWHAZ    YWHAQ    SFN    14-3-3 protein
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    YWHAH for paralogs           About GeneDecksing



    Genomic Variants
    for YWHAH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/286 NCBI SNPs in YWHAH are shown (see all 286)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs738842411,2
    		C--32338615(+) CTCCCA/GTCTCT 2 -- int1 us2k12Minor allele frequency- G:0.16WA 120
    rs1420837981,2
    		--32338644(+) ATGGGC/GGGTGG 2 -- int1 us2k10--------
    rs1511459461,2
    		--32338668(+) TTACTA/CTCTAG 2 -- us2k1 int10--------
    rs1402635161,2
    		--32339002(+) TAAGGA/GTCCTG 2 -- us2k1 int10--------
    rs1919839771,2
    		--32339121(+) CCTCCC/GTTCTC 2 -- us2k1 int10--------
    rs803225191,2
    		C--32339183(+) CTTCCA/CAATTA 2 -- int1 us2k10--------
    rs96093911,2
    		F--32339185(+) TCCCAA/GTTACC 2 -- us2k1 int11Minor allele frequency- G:0.09NA 120
    rs9290361,2
    		C,F,A,H--32339213(+) ATCTTC/TGGCCT 2 -- int1 us2k142Minor allele frequency- T:0.47EA NA NS WA CSA 5051
    rs1453713391,2
    		--32339275(+) TTAGGC/TCTCTC 2 -- us2k1 int10--------
    rs59981851,2
    		--32339365(+) CAAGAC/TCCAGC 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for YWHAH (32340447 - 32353590 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for YWHAH: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing YWHAH
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAH

    Disorders / Diseases
    for YWHAH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    YWHAH for disorders           About GeneDecksing

    OMIM gene information: 113508    OMIM disorders: --

    15 diseases for YWHAH:    About MalaCards
    bipolar disorder    schizophrenia    sporadic breast cancer    insulin resistance
    squamous cell carcinoma    lipodystrophy    myeloid leukemia    parkinson's disease
    breast cancer    leukemia    immunodeficiency    carcinoma
    malaria    neuronitis    alcoholism

    2 Novoseek disease relationships for YWHAH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 2 10206237 (1), 11121172 (1)
    tumors 0 1 1578511 (1)

    Genetic Association Database (GAD): YWHAH
    Human Genome Epidemiology (HuGE) Navigator: YWHAH (4 documents)

    Export disorders for YWHAH gene to outside databases

    Publications
    for YWHAH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for YWHAH gene, integrated from 9 sources (see all 125) (see top 10):
    (articles sorted by number of sources associating them with YWHAH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain. (PubMed id 1578511)1, 2, 9 Ichimura-Ohshima Y.... Kuwano R. (1992)
    2. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. (PubMed id 8218406)1, 2, 9 Swanson K.D.... Joshi J.G. (1993)
    3. 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia. (PubMed id 10206237)1, 4, 9 Toyooka K....Takahashi Y. (1999)
    4. Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia. (PubMed id 11121172)1, 4, 9 Bell R....Collier D.A. (2000)
    5. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (2008)
    6. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (2005)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. 14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta. (PubMed id 12480176)1, 4 Ubl A....Riess O. (2002)
    11. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)1, 2 Sato S....Tsuruo T. (2002)
    12. Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. (PubMed id 11266503)1, 2 Zilliacus J....Gustafsson J.-A. (2001)
    13. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    14. Structural organization and chromosomal assignment of the human 14-3- 3 eta chain gene (YWHAH). (PubMed id 8812417)1, 2 Muratake T.... Takahashi Y. (1996)
    15. The effect on methamphetamine on the mRNA level for 14.3.3 eta chain in the human cultured cells. (PubMed id 8561965)1, 2 Muratake T.... Kondo H. (1995)
    16. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)1, 2 Leffers H.... Celis J.E. (1993)
    17. The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein. (PubMed id 16545136)1, 9 Namkoong H....Kim J.W. (2006)
    18. A polymorphism in the YWHAH gene encoding 14-3-3 eta t hat is not associated with sporadic Creutzfeldt-Jakob disease (CJD). (PubMed id 21739144)1 Yun J....Kim Y.S. (2012)
    19. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    20. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    21. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-b type I receptor. (PubMed id 22706160)1 Zhang L....ten Dijke P. (2012)
    22. 14-3-3 checkpoint regulatory proteins interact specif ically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. (PubMed id 22222486)1 Andersen S.D....Rasmussen L.J. (2012)
    23. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    24. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    25. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    26. Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma. (PubMed id 21432775)1 Li X.H....Takano Y. (2011)
    27. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    28. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    29. Dermal fibroblasts influence the expression profile o f 14-3-3 proteins in human keratinocytes. (PubMed id 21416292)1 Carr M....Ghahary A. (2011)
    30. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    31. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)1 Greco T.M....Cristea I.M. (2011)
    32. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    33. Vpr-host interactions during HIV-1 viral life cycle. (PubMed id 21318276)1 Zhao R.Y....Bukrinsky M.I. (2011)
    34. 14-3-3 binding to LRRK2 is disrupted by multiple Parki nson's disease-associated mutations and regulates cytoplasmic localization. (PubMed id 20642453)1 Nichols R.J....Alessi D.R. (2010)
    35. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (2010)
    36. Histone deacetylase 7 controls endothelial cell growt h through modulation of beta-catenin. (PubMed id 20224040)1 Margariti A....Zeng L. (2010)
    37. The expression of seven 14-3-3 isoforms in human meni ngioma. (PubMed id 20388496)1 Liu Y....Zhang X. (2010)
    38. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    39. SLy2 targets the nuclear SAP30/HDAC1 complex. (PubMed id 20478393)1 Brandt S....Beer-Hammer S. (2010)
    40. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    41. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    42. Vpr and its interactions with cellular proteins. (PubMed id 20012529)1 Planelles V. and Benichou S. (2009)
    43. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    44. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    45. Identification of five novel 14-3-3 isoforms interact ing with the GPIb-IX complex in platelets. (PubMed id 19558434)1 Mangin P.H....Lanza F. (2009)
    46. Family-based association of YWHAH in psychotic bipolar disorder. (PubMed id 19160447)1 Grover D....Potash J.B. (2009)
    47. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1 Vega A....Carracedo A. (2009)
    48. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    49. Ribosomal proteins are targets for the NEDD8 pathway. (PubMed id 18274552)1 Xirodimas D.P....Hay R.T. (2008)
    50. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
    51. Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation. (PubMed id 18397886)1 Czirjak G....Enyedi P. (2008)
    52. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PubMed id 18779327)1 Courchet J....Billaud M. (2008)
    53. Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. (PubMed id 19034380)1 Martins-de-Souza D....Dias-Neto E. (2008)
    54. A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. (PubMed id 17979178)1 Gloeckner C.J....Ueffing M. (2007)
    55. Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation. (PubMed id 17255105)1 Palmer D....Maurice D.H. (2007)
    56. Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation. (PubMed id 17611984)1 Kilani R.T....Ghahary A. (2007)
    57. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (2007)
    58. 14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels. (PubMed id 16716084)1 Nagaki K....Ichimura T. (2006)
    59. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. (PubMed id 16775625)1 Gao Y.... Chen J. (2006)
    60. Structural basis for protein-protein interactions in the 14-3-3 protein family. (PubMed id 17085597)2 Yang X.... Elkins J.M. (2006)
    61. HIV-1 Vpr induces G2 cell cycle arrest in fission yeast associated with Rad24/14-3-3-dependent, Chk1/Cds1-independent Wee1 upregulation. (PubMed id 16968670)1 Matsuda N....Masuda M. (2006)
    62. 14-3-3eta is a novel regulator of parkin ubiquitin ligase. (PubMed id 16096643)1 Sato S....Tanaka K. (2006)
    63. 14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay. (PubMed id 16902409)1 He C. and Schneider R. (2006)
    64. 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. (PubMed id 16728661)1 Allouis M....Baro I. (2006)
    65. Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression. (PubMed id 16581770)1 Gong W....Riabowol K. (2006)
    66. Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members. (PubMed id 16868027)1 Godde N.J....Novak U. (2006)
    67. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. (PubMed id 16511560)1 LeBron C....Chen J. (2006)
    68. Role of 14-3-3 eta as a positive regulator of the glucocorticoid receptor transcriptional activation. (PubMed id 15790729)1 Kim Y.S....Ko J. (2005)
    69. Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest. (PubMed id 15708996)1 Kino T....Pavlakis G.N. (2005)
    70. BCR kinase phosphorylates 14-3-3 Tau on residue 233. (PubMed id 16045749)1 Clokie S.J....Aitken A. (2005)
    71. Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage. (PubMed id 15580267)1 Wanzel M....Eilers M. (2005)
    72. [Association study between NPY and YWHAH gene polymorphisms and schizophrenia] (PubMed id 16459651)1 Wang H.S....He L. (2005)
    73. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)1 Brajenovic M.... Drewes G. (2004)
    74. Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression. (PubMed id 15116094)1 Robb V.A....Gutmann D.H. (2004)
    75. Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins. (PubMed id 15023544)1 Subramanian R.R....Fu H. (2004)
    76. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)1 Jin J....Pawson T. (2004)
    77. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1 Bouwmeester T....Superti-Furga G. (2004)
    78. Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? (PubMed id 15265780)1 Kino T. and Chrousos G.P. (2004)
    79. Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. (PubMed id 15142377)1 Kino T. and Pavlakis G.N. (2004)
    80. Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo. (PubMed id 12507503)1 Chaudhri M....Aitken A. (2003)
    81. Interaction of the parathyroid hormone receptor with the 14-3-3 protein. (PubMed id 12595070)1 Tazawa H....Zilliacus J. (2003)
    82. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. (PubMed id 14690447)1 Surpili M.J....Kobarg J. (2003)
    83. Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. (PubMed id 12730237)1 Kino T....Chrousos G.P. (2003)
    84. Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus. (PubMed id 12871946)1 Sun L....Holz R.W. (2003)
    85. Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. (PubMed id 14504289)2 Fujita N.... Tsuruo T. (2003)
    86. The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. (PubMed id 12919677)1 Santoro M.M....Marchisio P.C. (2003)
    87. Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. (PubMed id 11969417)1 Ichimura T....Isobe T. (2002)
    88. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). (PubMed id 12438239)1 Liu M.Y....Walker C.L. (2002)
    89. 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity. (PubMed id 11953308)1 Kagan A....McDonald T.V. (2002)
    90. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1 Fujita N.... Tsuruo T. (2002)
    91. Identification and characterization of the interaction between tuberin and 14-3-3zeta. (PubMed id 12176984)1 Nellist M....Halley D.J. (2002)
    92. Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. (PubMed id 12433946)1 Rajan S....Daut J. (2002)
    93. The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins. (PubMed id 11996670)1 Yu T....Newsham I.F. (2002)
    94. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. (PubMed id 12176995)1 Lim R....Klinken S.P. (2002)
    95. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. (PubMed id 11886850)1 Johnson B.A....Blackwell T.K. (2002)
    96. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. (PubMed id 11864996)1 Brunet A....Yaffe M.B. (2002)
    97. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    98. HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. (PubMed id 11531413)1 Elder R.T....Zhao Y. (2001)
    99. Identification of a novel interaction of 14-3-3 with p190RhoGEF. (PubMed id 11533041)1 Zhai J....Canete-Soler R. (2001)
    100. The chaperone protein 14-3-3eta interacts with the nicotinic acetylcholine receptor alpha 4 subunit. Evidence for a dynamic role in subunit stabilization. (PubMed id 11352901)1 Jeanclos E.M....Anand R. (2001)
    101. Functional conservation of 14-3-3 isoforms in inhibiti ng bad-induced apoptosis. (PubMed id 11697890)1 Subramanian R.R....Fu H. (2001)
    102. Association study between genetic polymorphisms in the 14-3-3 eta chain and dopamine D4 receptor genes and alcoholism. (PubMed id 10776673)4 Ishiguro H....Arinami T. (2000)
    103. 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation. (PubMed id 10620507)1 Van Der Hoeven P.C....Van Blitterswijk J. (2000)
    104. Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase. (PubMed id 10713667)1 Mils V....Ducommun B. (2000)
    105. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. (PubMed id 10330186)1 Dalal S.N....DeCaprio J.A. (1999)
    106. Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins. (PubMed id 10441394)1 Finlin B.S. and Andres D.A. (1999)
    107. Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins. (PubMed id 9738002)1 Tang S.J....Buchwald M. (1998)
    108. A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. (PubMed id 9705322)1 Megidish T....Hakomori S. (1998)
    109. Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. (PubMed id 9524113)1 Ku N.O.... Omary M.B. (1998)
    110. Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins. (PubMed id 9799109)1 Le Bouffant F....Sladeczek F. (1998)
    111. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. (PubMed id 9299557)1 De Valck D....Beyaert R. (1997)
    112. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. (PubMed id 9278512)1 Peng C.Y....Piwnica-Worms H. (1997)
    113. The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins. (PubMed id 9197417)1 Sladeczek F....Le Bouffant F. (1997)
    114. Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. (PubMed id 9369453)1 Hsu S.Y....Hsueh A.J. (1997)
    115. Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein. (PubMed id 9079630)1 Wakui H....Zilliacus J. (1997)

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    Entrez Gene: 7533 HGNC: 12853 AceView: YWHAH Ensembl:ENSG00000128245 euGenes: HUgn7533
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