Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



YWHAH Gene

protein-coding   GIFtS: 70
GCID: GC22P032340

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation...

(Previous names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation...)
(Previous symbol: YWHA1)
  See YWHAH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Eta1 2
YWHA11 2 3 5
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein,
Eta Polypeptide1 2
14-3-3 Eta1 2
14-3-3 Protein Eta2
Protein AS13

External Ids:    HGNC: 128531   Entrez Gene: 75332   Ensembl: ENSG000001282457   OMIM: 1135085   UniProtKB: Q049173   
ORGUL members:         

Export aliases for YWHAH gene to outside databases

Previous GC identifers: GC22P029036 GC22P030665 GC22P015296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for YWHAH Gene:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to
phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and
this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence
in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and
psychotic bipolar disorder. (provided by RefSeq, Jun 2009)

GeneCards Summary for YWHAH Gene:
YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta) is a protein-coding gene. Diseases associated with YWHAH include early-onset schizophrenia, and bipolar disorder. GO annotations related to this gene include enzyme binding and protein heterodimerization activity. An important paralog of this gene is YWHAE.

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Negatively regulates the kinase activity of PDPK1

summary for YWHAH Gene:
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes
such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3
proteins are phospho-serine/phospho-threonine binding proteins that have a diverse array of partners
including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signalling molecules,
apoptosis factors and tumour suppressors. The 14.3.3 family consists of 7 isoforms; beta, gamma, epsilon,
sigma, zeta, tau and eta. 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and
heterodimers, with the exception of 14.3.3sigma, which exclusively forms homodimers and is found in cells of
epithelial origin only. Each monomer contains an independent ligand-binding site, thus the 14.3.3 dimer can
interact with two target proteins simultaneously. 14.3.3 proteins are highly rigid structures and ligand
binding can induce conformational changes that alter the stability and/or catalytic activity of the ligand.
Furthermore, 14.3.3 protein binding can physically occlude sequence-specific or structural motifs on the
target that prevent molecular interactions and/or modulate the accessibility of a target protein to
modifying enzymes such as kinases, phosphatases and proteases. In addition, 14.3.3 proteins can act as a
scaffold molecule to anchor target proteins within close proximity of one another. 14.3.3 proteins represent
an integration point for proliferative, survival, apoptotic and stress signalling pathways. Members of the
14.3.3 protein family enhance the activity of many proteins with proliferative and/or survival functions,
such as Raf kinases, and antagonise the activity of proteins that promote cell death and senescence, such as
Bad, Bim and Bax. In contrast, 14.3.3sigma acts as a tumour suppressor and its expression is upregulated
coordinately with p53 and BRAC1. This isoform sequesters cdk1-cyclin B complexes in the cytoplasm, and thus
delays cell cycle progression. 14.3.3sigma is also a crucial regulator of translation during mitosis.
Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into
the core regulatory pathways that are crucial for normal growth and development. 14.3.3 proteins are
directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent
growth and cell adhesion, and it is these pathways that often become dysregulated in disease states such as
cancer.

Gene Wiki entry for YWHAH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the YWHAH gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): YWHAH promoter sequence
   Search Chromatin IP Primers for YWHAH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.1-q13.1

YWHAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
YWHAH gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P032340:  view genomic region     (about GC identifiers)

Start:
32,340,447 bp from pter      End:
32,353,590 bp from pter
Size:
13,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917 (See protein sequence)
Recommended Name: 14-3-3 protein eta  
Size: 246 amino acids; 28219 Da
Subunit: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR,
ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction
retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B.
Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By
similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1
2 PDB 3D structures from and Proteopedia for YWHAH:
2C63 (3D)        2C74 (3D)    

Explore the universe of human proteins at neXtProt for YWHAH: NX_Q04917

Explore proteomics data for YWHAH at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (By
    similarity)1
  • Ubiquitination2 at Lys50, Lys69, Lys110, Lys125, Lys127
  • Modification sites at PhosphoSitePlus

  • See YWHAH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003396.1  
    ENSEMBL proteins: 
     ENSP00000248975   ENSP00000408468   ENSP00000380629   ENSP00000406747  
    Reactome Protein details: Q04917

    YWHAH Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for YWHAH
    OriGene Purified Protein for YWHAH
    OriGene Protein Over-expression Lysate for YWHAH
    OriGene MassSpec for YWHAH
    OriGene Custom Protein Services for YWHAH
    GenScript Custom Purified and Recombinant Proteins Services for YWHAH
    Novus Biologicals YWHAH Proteins
    Novus Biologicals YWHAH Lysate
    Sino Biological Recombinant Protein for YWHAH
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for YWHAH
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for YWHAH 

     
    antibodies-online proteins for YWHAH (10 products) 

     
    antibodies-online peptides for YWHAH

    YWHAH Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
    R&D Systems Antibodies for YWHAH (14-3-3 eta)
    Cell Signaling Technology (CST) Antibodies for YWHAH  (14-3-3 eta)
    OriGene Antibodies for YWHAH
    OriGene Custom Antibody Services for YWHAH
    Novus Biologicals YWHAH Antibodies
    Abcam antibodies for YWHAH
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for YWHAH
    antibodies-online antibodies for YWHAH (43 products) 

    YWHAH Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for YWHAH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for YWHAH
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for YWHAH 
    antibodies-online kits for YWHAH (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR023409 14-3-3_CS
     IPR023410 14-3-3_domain
     IPR000308 14-3-3

    Graphical View of Domain Structure for InterPro Entry Q04917

    ProtoNet protein and cluster: Q04917

    1 Blocks protein domain: IPB000308 14-3-3 protein

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Similarity: Belongs to the 14-3-3 family


    Find genes that share domains with YWHAH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 1433F_HUMAN, Q04917
    Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized
    signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or
    phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
    Negatively regulates the kinase activity of PDPK1

         Genatlas biochemistry entry for YWHAH:
    tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 eta protein,multifunctional regulator
    involved in cell-cyle control (checkpoint), and signal transduction,inhibitor of apoptosis through inhibiting the
    activation of p38 MAP kinase

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005159insulin-like growth factor receptor binding ISS--
    GO:0005515protein binding IPI10713667
    GO:0017080sodium channel regulator activity IDA16728661
    GO:0019899enzyme binding IPI17255105
         
    Find genes that share ontologies with YWHAH           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Ywhah (no phenotypes)

    Find genes that share phenotypes with YWHAH           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for YWHAH

    miRNA
    Products:
        
    miRTarBase miRNAs that target YWHAH:
    hsa-mir-186-5p (MIRT021116), hsa-mir-16-5p (MIRT032075), hsa-mir-32-5p (MIRT028327), hsa-mir-103a-3p (MIRT027235), hsa-mir-324-5p (MIRT043064), hsa-mir-33a-5p (MIRT028247)

    Block miRNA regulation of human, mouse, rat YWHAH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAH 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for YWHAH
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for YWHAH

    Clone
    Products:
         
    OriGene clones in human, mouse for YWHAH (see all 6)
    OriGene ORF clones in mouse, rat for YWHAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
    Sino Biological Human cDNA Clone for YWHAH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH
    Addgene plasmids for YWHAH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for YWHAH
    Browse ESI BIO Cell Lines and PureStem Progenitors for YWHAH 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA16728661
    GO:0014704intercalated disc IC16728661
    GO:0030659cytoplasmic vesicle membrane TAS--

    Find genes that share ontologies with YWHAH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for YWHAH About   (see all 46)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45
    14-3-3 and Cell Cycle Regulation0.45
    3Development Dopamine D2 receptor transactivation of EGFR
    Apoptosis and survival BAD phosphorylation0.41
    BAD Phosphorylation0.41
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5Activation of BH3-only proteins
    Activation of BH3-only proteins0.68
    Activation of BAD and translocation to mitochondria0.00
    Intrinsic Pathway for Apoptosis0.68


    Find genes that share SuperPaths with YWHAH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for YWHAH
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for YWHAH (see all 18)
        14-3-3 Induced Apoptosis
    DHA Signaling
    PKA Signaling
    ERK5 Signaling
    BDNF Pathway

    3 Cell Signaling Technology (CST) Pathways for YWHAH
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Tyrosine Kinases / Adaptors

    2 Tocris Bioscience Pathways for YWHAH
        Insulin Pathway
    Apoptosis Pathway

    4 GeneGo (Thomson Reuters) Pathways for YWHAH
        Apoptosis and survival BAD phosphorylation
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for YWHAH (see all 18)
        Myometrial Relaxation and Contraction Pathways
    Cell cycle
    SIDS Susceptibility Pathways
    Calcium Regulation in the Cardiac Cell
    Alpha6-Beta4 Integrin Signaling Pathway


    2 Reactome Pathways for YWHAH
        Activation of BAD and translocation to mitochondria
    Translocation of GLUT4 to the plasma membrane


    Selected Kegg Pathways  (Kegg details for YWHAH) (see all 6):
        Cell cycle
    Oocyte meiosis
    PI3K-Akt signaling pathway
    Hippo signaling pathway
    Epstein-Barr virus infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for YWHAH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for YWHAH (Q049171, 2, 3 ENSP000002489754) via UniProtKB, MINT, STRING, and/or I2D (see all 480)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25BP303051, 2, 3, ENSP000002459604EBI-306940,EBI-1051746 MINT-8007505 MINT-25118 MINT-19328 MINT-19330 I2D: score=4 STRING: ENSP00000245960
    HDAC4P565241, 2, 3, ENSP000002646064EBI-306940,EBI-308629 MINT-8008113 I2D: score=2 STRING: ENSP00000264606
    YWHAQP273482, 3, ENSP000002380814MINT-7300139 MINT-7264099 MINT-7899812 I2D: score=3 STRING: ENSP00000238081
    PTH1RQ034312, 3, ENSP000003219994MINT-15642 MINT-15641 MINT-5207093 I2D: score=2 STRING: ENSP00000321999
    YWHAEP622582, 3, ENSP000002643354MINT-7300139 MINT-7899812 I2D: score=6 STRING: ENSP00000264335
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002028regulation of sodium ion transport IDA16728661
    GO:0006713glucocorticoid catabolic process IDA15790729
    GO:0006886intracellular protein transport ISS--
    GO:0006915apoptotic process TAS--
    GO:0021762substantia nigra development IEP--

    Find genes that share ontologies with YWHAH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for YWHAH available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DifopeinHigh affinity inhibitor of 14.3.3 proteins; induces apoptosis[396834-58-5]
    R18Inhibitor of 14.3.3 proteins; induces apoptosis[211364-78-2]

    1 Novoseek inferred chemical compound relationship for YWHAH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 33.8 1 16545136 (1)



    Find genes that share compounds with YWHAH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for YWHAH gene: 
    NM_003405.3  

    Unigene Cluster for YWHAH:

    Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
    Hs.226755  [show with all ESTs]
    Unigene Representative Sequence: NM_003405
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248975(uc003alz.3) ENST00000443669 ENST00000397492 ENST00000479649
    ENST00000471374(uc003ama.3 uc010gwm.3) ENST00000420430
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat YWHAH using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate YWHAH (see all 20):
    hsa-miR-3128 hsa-miR-15a hsa-miR-103a hsa-miR-583 hsa-miR-424 hsa-miR-1323 hsa-miR-3908 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidYWHAH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for YWHAH
    Predesigned siRNA for gene silencing in human, mouse, rat YWHAH
    Clone
    Products:
         
    OriGene clones in human, mouse for YWHAH (see all 6)
    OriGene ORF clones in mouse, rat for YWHAH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: YWHAH (NM_003405)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for YWHAH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH
    Addgene plasmids for YWHAH 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for YWHAH
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YWHAH
      QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
      QuantiFast Probe-based Assays in human, mouse, rat YWHAH

    Additional mRNA sequence: 

    AK307750.1 AK312650.1 AY007132.1 BC003047.1 CR456612.1 L08439.1 L20422.1 S80794.1 
    X57345.1 X78138.1 

    Selected DOTS entries (see all 36):

    DT.95111929  DT.448876  DT.101976744  DT.100711364  DT.407748  DT.120670119  DT.91783556  DT.100851802 
    DT.100700123  DT.100637903  DT.97771863  DT.120670168  DT.95109036  DT.99965707  DT.100733502  DT.100847487 
    DT.100852063  DT.92342680  DT.100637738  DT.100647593  DT.100650467  DT.100647591  DT.100659038  DT.100662630 

    Selected AceView cDNA sequences (see all 810):

    CA407179 BU196763 BQ130708 BQ267143 CA397229 BM764472 CR603635 AU119302 
    BM765261 CR596702 F04963 CR596240 BU170128 AA605146 AI423963 BQ787495 
    BQ072030 BU786149 CR624998 CR456612 BU947953 AU142852 H11617 AI470204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for YWHAH (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -     -     -     -                                       
    SP2:                    -     -           -     -                                 
    SP3:                    -     -     -     -     -                                 
    SP4:                    -                                                         
    SP5:                          -     -     -     -                                 


    ECgene alternative splicing isoforms for YWHAH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    YWHAH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATCAAGA
    YWHAH Expression
    About this image


    YWHAH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
    YWHAH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    YWHAH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.226755

    UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
    Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including YWHAH: 
              Multiple Sclerosis in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for YWHAH
    OriGene qSTAR qPCR primer pairs in human, mouse for YWHAH
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YWHAH
    QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
    QuantiFast Probe-based Assays in human, mouse, rat YWHAH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for YWHAH gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ywhah1 , 5 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more1, 5 93.22(n)1
    99.19(a)1
      5 (17.42 cM)5
    226291  NM_011738.21  NP_035868.11 
     330188165 
    chicken
    (Gallus gallus)
    Aves YWHAH1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more 85.91(n)
    97.97(a)
      416955  NM_001007839.1  NP_001007840.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    2(118187473-118188219)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045230.12   -- 80.56(n)    BC045230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb51h042 Danio rerio cDNA clone MGC63883 IMAGE6789640, complete more 78.49(n)    BC053130.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M117.36
    Protein M117.3 (M117.3) mRNA, complete cds
    38(a)
    1 → many
    IV(11823371-11823938) WBGene00010919
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BMH16
    BMH26
    14-3-3 protein, major isoform; controls proteome a...
    14-3-3 protein, minor isoform; controls proteome a...
    56(a)
    55(a)
    many ↔ many
    many ↔ many
    V(545611-546414) YER177W
    IV(653607-654428) YDR099W


    ENSEMBL Gene Tree for YWHAH (if available)
    TreeFam Gene Tree for YWHAH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for YWHAH gene
    YWHAE2  YWHAB2  YWHAQ2  YWHAG2  SFN2  YWHAZ2  
    9 SIMAP similar genes for YWHAH using alignment to 4 protein entries:     1433F_HUMAN (see all proteins):
    YWHAG    YWHAB    YWHAZ    YWHAQ    SFN    14-3-3 protein
    YWHAE    YWHAE/FAM22A fusion    YWHAE/FAM22B fusion

    Find genes that share paralogs with YWHAH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for YWHAH (see all 232)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910129111,2
    --32343405(+) CACTTA/GATAAT 1 -- int10--------
    rs1831334371,2
    --32343452(+) CCAGCA/GTCACC 1 -- int10--------
    rs762705741,2
    C--32343478(+) GTAAGA/CTTGAA 1 -- int10--------
    rs1883118861,2
    C--32343508(+) AAACAA/GTGGTC 1 -- int10--------
    rs106317881,2
    C--32343613(+) TCAAGCTCT/-  
            
    CTCTA
    1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs343249181,2
    C--32343614(+) CAAGC-/CTCT  
            
    TCTAT
    1 -- int10--------
    rs1498527091,2
    C--32343662(+) AAGAAA/GTATTG 1 -- int10--------
    rs1466569501,2
    --32343680(+) TTCTAC/GAACCT 1 -- int10--------
    rs738842431,2
    C,F--32343831(+) ACCAGA/GTAGAT 1 -- int13Minor allele frequency- G:0.05WA NA 240
    rs9332261,2
    C,F,O,A,H--32343847(+) GTGGAT/CATTCA 1 -- int122Minor allele frequency- C:0.11EA NA MN NS 1606

    HapMap Linkage Disequilibrium report for YWHAH (32340447 - 32353590 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for YWHAH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508731CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing YWHAH
    DNA2.0 Custom Variant and Variant Library Synthesis for YWHAH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 113508    OMIM disorders: --

    3 diseases for YWHAH:    
    About MalaCards
    early-onset schizophrenia    bipolar disorder    schizophrenia


    Find genes that share disorders with YWHAH           About GenesLikeMe

    2 Novoseek inferred disease relationships for YWHAH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 2 10206237 (1), 11121172 (1)
    tumors 0 1 1578511 (1)

    Genetic Association Database (GAD): YWHAH
    Human Genome Epidemiology (HuGE) Navigator: YWHAH (4 documents)

    Export disorders for YWHAH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for YWHAH gene, integrated from 10 sources (see all 150) (see top 10):
    (articles sorted by number of sources associating them with YWHAH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain. (PubMed id 1578511)1, 2, 9 Ichimura-Ohshima Y.... Kuwano R. (J. Neurosci. Res. 1992)
    2. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. (PubMed id 8218406)1, 2, 9 Swanson K.D.... Joshi J.G. (Biochim. Biophys. Acta 1993)
    3. 14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia. (PubMed id 10206237)1, 4, 9 Toyooka K....Takahashi Y. (Am. J. Med. Genet. 1999)
    4. Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia. (PubMed id 11121172)1, 4, 9 Bell R....Collier D.A. (Am. J. Med. Genet. 2000)
    5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    6. Family-based association of YWHAH in psychotic bipolar disorder. (PubMed id 19160447)1, 4 Grover D....Potash J.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. (PubMed id 19172738)1, 2 Brummer T.... Daly R.J. (EMBO J. 2008)
    8. [Association study between NPY and YWHAH gene polymorphisms and schizophrenia]. (PubMed id 16459651)1, 4 Wang H.S....He L. (Yi Chuan Xue Bao 2005)
    9. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1, 2 Yoshida K.... Miki Y. (Nat. Cell Biol. 2005)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    11. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    12. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    13. 14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta. (PubMed id 12480176)1, 4 Ubl A....Riess O. (Brain Res. Mol. Brain Res. 2002)
    14. Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. (PubMed id 12177059)1, 2 Sato S.... Tsuruo T. (J. Biol. Chem. 2002)
    15. Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. (PubMed id 11266503)1, 2 Zilliacus J....Gustafsson J.-A. (Mol. Endocrinol. 2001)
    16. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    17. Structural organization and chromosomal assignment of the human 14-3- 3 eta chain gene (YWHAH). (PubMed id 8812417)1, 2 Muratake T.... Takahashi Y. (Genomics 1996)
    18. The effect on methamphetamine on the mRNA level for 14.3.3 eta chain in the human cultured cells. (PubMed id 8561965)1, 2 Muratake T.... Kondo H. (Mol. Neurobiol. 1995)
    19. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. (PubMed id 8515476)1, 2 Leffers H.... Celis J.E. (J. Mol. Biol. 1993)
    20. The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein. (PubMed id 16545136)1, 9 Namkoong H....Kim J.W. (BMC Cancer 2006)
    21. A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. (PubMed id 23938468)1 Lin A.E....Cristea I.M. (amp 2013)
    22. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)
    23. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    24. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. (PubMed id 23428871)1 Erazo T....Lizcano J.M. (Mol. Cell. Biol. 2013)
    25. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (PLoS ONE 2013)
    26. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    27. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    28. Roles of 14-3-3I^ in mitotic progression and its potential use as a therapeutic target for cancers. (PubMed id 22562251)1 Lee C.G....Lee C.W. (Oncogene 2013)
    29. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    30. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    31. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    32. A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD). (PubMed id 21739144)1 Yun J....Kim Y.S. (Mol. Biol. Rep. 2012)
    33. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    34. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    35. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-I^ type I receptor. (PubMed id 22706160)1 Zhang L....ten Dijke P. (Nat. Cell Biol. 2012)
    36. 14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. (PubMed id 22222486)1 Andersen S.D....Rasmussen L.J. (DNA Repair (Amst.) 2012)
    37. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    38. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    39. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    40. Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma. (PubMed id 21432775)1 Li X.H....Takano Y. (Histol. Histopathol. 2011)
    41. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    42. Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes. (PubMed id 21416292)1 Carr M....Ghahary A. (Mol. Cell. Biochem. 2011)
    43. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    44. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    45. Vpr-host interactions during HIV-1 viral life cycle. (PubMed id 21318276)1 Zhao R.Y....Bukrinsky M.I. (J Neuroimmune Pharmacol 2011)
    46. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    47. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    48. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)
    49. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    50. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    51. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)1 Greco T.M....Cristea I.M. (amp 2011)
    52. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    53. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. (PubMed id 20639865)1 Xu G....Jaffrey S.R. (Nat. Biotechnol. 2010)
    54. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. (PubMed id 20642453)1 Nichols R.J....Alessi D.R. (Biochem. J. 2010)
    55. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-I^-SMAD pathway. (PubMed id 21145499)1 Varelas X....Wrana J.L. (Dev. Cell 2010)
    56. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    57. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (FEBS J. 2010)
    58. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. (PubMed id 20224040)1 Margariti A....Zeng L. (Circ. Res. 2010)
    59. The expression of seven 14-3-3 isoforms in human meningioma. (PubMed id 20388496)1 Liu Y....Zhang X. (Brain Res. 2010)
    60. SLy2 targets the nuclear SAP30/HDAC1 complex. (PubMed id 20478393)1 Brandt S....Beer-Hammer S. (amp 2010)
    61. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    62. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    63. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    64. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    65. Vpr and its interactions with cellular proteins. (PubMed id 20012529)1 Planelles V. and Benichou S. (Curr. Top. Microbiol. Immunol. 2009)
    66. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    67. Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets. (PubMed id 19558434)1 Mangin P.H....Lanza F. (J. Thromb. Haemost. 2009)
    68. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    69. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    70. Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. (PubMed id 19034380)1 Martins-de-Souza D....Dias-Neto E. (J Neural Transm 2009)
    71. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (J. Proteome Res. 2008)
    72. Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation. (PubMed id 18397886)1 CzirjA!k G....Enyedi P. (J. Biol. Chem. 2008)
    73. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PubMed id 18779327)1 Courchet J.... Billaud M. (J. Biol. Chem. 2008)
    74. Ribosomal proteins are targets for the NEDD8 pathway. (PubMed id 18274552)1 Xirodimas D.P....Hay R.T. (EMBO Rep. 2008)
    75. A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes. (PubMed id 17979178)1 Gloeckner C.J....Ueffing M. (Proteomics 2007)
    76. Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation. (PubMed id 17255105)1 Palmer D....Maurice D.H. (J. Biol. Chem. 2007)
    77. Detection of high levels of 2 specific isoforms of 14-3-3 proteins in synovial fluid from patients with joint inflammation. (PubMed id 17611984)1 Kilani R.T....Ghahary A. (J. Rheumatol. 2007)
    78. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    79. Structural basis for protein-protein interactions in the 14-3-3 protein family. (PubMed id 17085597)2 Yang X.... Elkins J.M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    80. 14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay. (PubMed id 16902409)1 He C. and Schneider R. (EMBO J. 2006)
    81. Subcellular targeting of p33ING1b by phosphorylation-dependent 14-3-3 binding regulates p21WAF1 expression. (PubMed id 16581770)1 Gong W....Riabowol K. (Mol. Cell. Biol. 2006)
    82. 14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels. (PubMed id 16716084)1 Nagaki K....Ichimura T. (Biochemistry 2006)
    83. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. (PubMed id 16775625)1 Gao Y.... Chen J. (Cell Res. 2006)
    84. HIV-1 Vpr induces G2 cell cycle arrest in fission yeast associated with Rad24/14-3-3-dependent, Chk1/Cds1-independent Wee1 upregulation. (PubMed id 16968670)1 Matsuda N....Masuda M. (Microbes Infect. 2006)
    85. 14-3-3eta is a novel regulator of parkin ubiquitin ligase. (PubMed id 16096643)1 Sato S....Tanaka K. (EMBO J. 2006)
    86. 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. (PubMed id 16728661)1 Allouis M....BarA^ I. (Circ. Res. 2006)
    87. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 16888623)1 Raina D....Kufe D. (EMBO J. 2006)
    88. Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members. (PubMed id 16868027)1 GAPdde N.J....Novak U. (J. Cell. Sci. 2006)
    89. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. (PubMed id 16511560)1 LeBron C....Chen J. (EMBO J. 2006)
    90. Role of 14-3-3 eta as a positive regulator of the glucocorticoid receptor transcriptional activation. (PubMed id 15790729)1 Kim Y.S....Ko J. (Endocrinology 2005)
    91. Involvement of protein kinase PKN1 in G2/M delay caused by arsenite. (PubMed id 15791647)1 Isagawa T....Ono Y. (Mol. Carcinog. 2005)
    92. Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage. (PubMed id 15580267)1 Wanzel M....Eilers M. (Nat. Cell Biol. 2005)
    93. Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest. (PubMed id 15708996)1 Kino T....Pavlakis G.N. (J. Virol. 2005)
    94. BCR kinase phosphorylates 14-3-3 Tau on residue 233. (PubMed id 16045749)1 Clokie S.J....Aitken A. (FEBS J. 2005)
    95. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. (PubMed id 16093354)1 Zhu J.... Tzivion G. (Mol. Biol. Cell 2005)
    96. Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. (PubMed id 16041367)1 Rajalingam K....Rudel T. (Nat. Cell Biol. 2005)
    97. Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression. (PubMed id 15116094)1 Robb V.A....Gutmann D.H. (Oncogene 2004)
    98. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)1 Jin J.... Pawson T. (Curr. Biol. 2004)
    99. Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? (PubMed id 15265780)1 Kino T. and Chrousos G.P. (Ann. N. Y. Acad. Sci. 2004)
    100. Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. (PubMed id 15142377)1 Kino T. and Pavlakis G.N. (DNA Cell Biol. 2004)
    101. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)1 Brajenovic M.... Drewes G. (J. Biol. Chem. 2004)
    102. Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins. (PubMed id 15023544)1 Subramanian R.R.... Fu H. (Exp. Cell Res. 2004)
    103. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1 Bouwmeester T....Superti-Furga G. (Nat. Cell Biol. 2004)
    104. Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo. (PubMed id 12507503)1 Chaudhri M....Aitken A. (Biochem. Biophys. Res. Commun. 2003)
    105. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. (PubMed id 14690447)1 Surpili M.J....Kobarg J. (Biochemistry 2003)
    106. Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. (PubMed id 12730237)1 Kino T....Chrousos G.P. (J. Biol. Chem. 2003)
    107. Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. (PubMed id 14504289)2 Fujita N.... Tsuruo T. (J. Biol. Chem. 2003)
    108. The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. (PubMed id 12919677)1 Santoro M.M....Marchisio P.C. (Dev. Cell 2003)
    109. Interaction of the parathyroid hormone receptor with the 14-3-3 protein. (PubMed id 12595070)1 Tazawa H....Zilliacus J. (Biochim. Biophys. Acta 2003)
    110. Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus. (PubMed id 12871946)1 Sun L....Holz R.W. (J. Biol. Chem. 2003)
    111. Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor. (PubMed id 14505491)1 Santoro M.M....Villa-Moruzzi E. (Biochem. J. 2003)
    112. Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. (PubMed id 11969417)1 Ichimura T....Isobe T. (Biochemistry 2002)
    113. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). (PubMed id 12438239)1 Liu M.Y....Walker C.L. (Cancer Res. 2002)
    114. 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity. (PubMed id 11953308)1 Kagan A....McDonald T.V. (EMBO J. 2002)
    115. The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins. (PubMed id 11996670)1 Yu T....Newsham I.F. (Biochem. J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7533 HGNC: 12853 AceView: YWHAH Ensembl:ENSG00000128245 euGenes: HUgn7533
    ECgene: YWHAH Kegg: 7533 H-InvDB: YWHAH

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for YWHAH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for YWHAH Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for YWHAH gene:
    Search GeneIP for patents involving YWHAH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
     
     EMD Millipore genomic analysis products

      
     Antibodies for YWHAH (14-3-3 eta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for YWHAH   OriGene RNAi products in human, mouse, rat for YWHAH  
     OriGene qPCR primer pairs and template standards for YWHAH   OriGene Protein Over-expression Lysate for YWHAH  
     OriGene MassSpec for YWHAH   OriGene clones in human, mouse for YWHAH  
     OriGene qSTAR qPCR primer pairs in human, mouse for YWHAH   OriGene Purified Protein for YWHAH  
     OriGene ORF clones in mouse, rat for YWHAH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for YWHAH   OriGene Custom Protein Services for YWHAH  

     
     
     Block miRNA regulation of human, mouse, rat YWHAH using miScript Target Protectors SeqTarget long-range PCR primers for resequencing YWHAH
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat YWHAH Predesigned siRNA for gene silencing in human, mouse, rat YWHAH
     QuantiFast Probe-based Assays in human, mouse, rat YWHAH QuantiTect SYBR Green Assays in human, mouse, rat YWHAH
     PCR Arrays including human, mouse, rat YWHAH Search Chromatin IP Primers for YWHAH
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat YWHAH  GeneGlobe Interaction Network for YWHAH
     Regulatory tfbs in YWHAH promoter
     GenScript Custom Purified and Recombinant Proteins Services for YWHAH GenScript cDNA clones with any tag delivered in your preferred vector for YWHAH
     GenScript Custom Assay Services for YWHAH GenScript Custom overexpressing Cell Line Services for YWHAH
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for YWHAH 
    (14-3-3 eta)

     Tocris compounds for YWHAH
     Proteins for YWHAH
     Browse Sino Biological Cell Lysates
     cDNA Clones for YWHAH
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for YWHAH
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     YWHAH antibodies
     YWHAH proteins
     YWHAH lysates
     Antibodies for YWHAH
     See all of Abcam's Antibodies, Kits and Proteins for YWHAH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for YWHAH
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for YWHAH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YWHAH
     SwitchGear 3'UTR luciferase reporter plasmids for YWHAH
     SwitchGear Promoter luciferase reporter plasmids for YWHAH
     ThermoFisher Antibodies for YWHAH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YWHAH
     Browse compounds at ApexBio
     Addgene plasmids for YWHAH
      Search eBioscience for proteins for YWHAH
      Search eBioscience for elisas for YWHAH
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for YWHAH
     antibodies-online antibodies for YWHAH (43 products)
     antibodies-online kits for YWHAH (20 products)
     antibodies-online peptides for YWHAH
     antibodies-online proteins for YWHAH (10 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      YWHAH gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4