Aliases for YWHAH Gene
External Ids for YWHAH Gene
Previous HGNC Symbols for YWHAH Gene
Previous GeneCards Identifiers for YWHAH Gene
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
GeneCards Summary for YWHAH Gene
YWHAH (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta) is a Protein Coding gene. Diseases associated with YWHAH include Schizophrenia and Bipolar Disorder. Among its related pathways are NFAT and Cardiac Hypertrophy and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and actin binding. An important paralog of this gene is YWHAG.
UniProtKB/Swiss-Prot for YWHAH Gene
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14.3.3 proteins are phospho-serine/-threonine binding proteins.