V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

YWHAH Gene

protein-coding GIFtS: 72

GC22P030665

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: YWHA1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
YWHA1 ^², ³, ⁵

Descriptions
14-3-3 eta ^²
Protein AS1 ^³
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide ^²

External Ids
HGNC: 12853¹
Entrez Gene: 7533²
UniProtKB: Q04917³
Ensembl: ENSG00000128245⁷

Search outside databases for aliases for YWHAH gene

Previous GC identifer: GC22P029036

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for YWHAH:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by

binding to phosphoserine-containing proteins. This highly conserved protein family is found in

both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs.

This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this

repeat has been associated with early-onset schizophrenia. [provided by RefSeq]

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Gene Wiki entry for YWHAH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the YWHAH gene

Entrez Gene cytogenetic band: 22q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12.1-q13.1

YWHAH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P030665: (about GC identifiers)

Start:	30,670,479 bp from pter
End:	30,683,590 bp from pter
Size:	13,112 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917 (See protein sequence)

Recommended Name: 14-3-3 protein eta

Size: 246 amino acids; 28219 Da

Subunit: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors

including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated

form); the interaction retains it in the cytoplasm. Interacts with RGNEF and PCTK1 (By

similarity). Weakly interacts with CDKN1B

PDB structure from and Proteopedia :

2C63 (3D)

2C74 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003396.1

ENSEMBL proteins:

ENSP00000380629 ENSP00000248975

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for YWHAH
	Recombinant Proteins from Abcam (14-3-3 eta, 14-3-3 eta + gamma + zeta)
	Human Recombinant Proteins from Abnova (YWHAH)

OriGene Purified Recombinant Human Protein: YWHAH

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--

About this table

Antibodies for YWHAH:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of YWHAH
	Sigma-Aldrich Antibodies for YWHAH
	R&D Systems Antibodies for YWHAH (14-3-3 eta)
	Antibodies from Abcam (14-3-3 eta, 14-3-3 eta + gamma + zeta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (YWHAH)
	Novus Biologicals Antibodies for YWHAH

Assays for YWHAH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q04917

ProtoNet protein and cluster: Q04917

1 Blocks protein family: IPB000308 14-3-3 protein

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917

Similarity: Belongs to the 14-3-3 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YWHAH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003405

Applied Biosystems Silencer® siRNAs for YWHAH

Sigma-Aldrich siRNA for YWHAH

Sigma-Aldrich shRNA for YWHAH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for YWHAH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003405
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003405
untagged cDNA clone in CMV expression vector: NM_003405

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003405

UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917

Function: Adapter protein implicated in the regulation of a large spectrum of both general and

specialized signaling pathway. Binds to a large number of partners, usually by recognition of a

phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the

activity of the binding partner

Genatlas biochemistry entry for YWHAH:

tyrosine 3-monooxygenase/trytophan 5 monooxygenase activation protein,14-3-3 eta

protein,multifunctional regulator involved in cell-cyle control (checkpoint), and signal

transduction,inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase

1 MGI phenotypic allele

for Ywhah (no phenotypes)

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	ISS	--
GO:0005159	insulin-like growth factor receptor binding	ISS	--
GO:0016563	transcription activator activity	IDA	15790729
GO:0019899	enzyme binding	IPI	17255105
GO:0019904	protein domain specific binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for YWHAH (Your Favorite Gene powered by Ingenuity) (see all 6 )

PI3K/AKT Signaling
IGF-1 Signaling
Glucocorticoid Receptor Signaling
14-3-3-mediated Signaling
ERK/MAPK Signaling

GeneDecks YWHAH for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for YWHAH

5/250 Interacting proteins for YWHAH (Q04917^{1, 2} ENSP00000248975³) via UniProtKB, MINT, and/or STRING (see all 250 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC25B	P30305², ENSP00000245960³	MINT-25118 MINT-19328 MINT-19330 STRING (score=.96)
RAF1	P04049¹, ENSP00000251849³	EBI-306940, EBI-365996 STRING (score=.979)
TSC2	P49815², ENSP00000219476³	MINT-16580 STRING (score=.975)
YWHAG	P61981², ENSP00000306330³	MINT-6542674 STRING (score=.932)
GREM1	O60565¹, ENSP00000300177³	EBI-306940, EBI-944395 STRING (score=.784)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006713	glucocorticoid catabolic process	IDA	15790729
GO:0006886	intracellular protein transport	ISS	--
GO:0042921	glucocorticoid receptor signaling pathway	IDA	15790729
GO:0045664	regulation of neuron differentiation	ISS	--
GO:0045941	positive regulation of transcription	IDA	15790729

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for YWHAH

Browse Small Molecules at Sigma-Aldrich

Compounds for YWHAH available from Tocris Bioscience

Compound	Action	CAS number
Difopein	High affinity inhibitor of 14.3.3 proteins; induces apoptosis	[396834-58-5]
R18	Inhibitor of 14.3.3 proteins; induces apoptosis	[211364-78-2]

About this table

1 Novoseek chemical compound relationship for YWHAH gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	34.60	1	16545136 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (YWHAH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (YWHAH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003405

Sigma-Aldrich siRNA for YWHAH

Sigma-Aldrich shRNA for YWHAH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003405

REFSEQ mRNAs for YWHAH gene:

NM_003405.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003405

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003405
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003405
                                 untagged cDNA clone in CMV expression vector: NM_003405

Additional cDNA sequence:

AK307750.1 AK312650.1 AY007132.1 BC003047.1 CR456612.1 CR593026.1 CR593097.1 CR593529.1

CR596240.1 CR596702.1 CR600337.1 CR600694.1 CR600773.1 CR601517.1 CR602331.1 CR603635.1

CR605523.1 CR606891.1 CR607325.1 CR607383.1 CR608665.1 CR611605.1 CR611926.1 CR614044.1

CR614377.1 CR614662.1 CR615723.1 CR615843.1 CR616670.1 CR617151.1 CR617238.1 CR618712.1

CR618980.1 CR619423.1 CR621211.1 CR622695.1 CR622989.1 CR624998.1 CR625039.1 L08439.1

L20422.1 S80794.1 X57345.1 X78138.1

24/36 DOTS entries (see all 36 ):

DT.95111929 DT.448876 DT.101976744 DT.100711364 DT.120670119 DT.407748 DT.100851802 DT.91783556

DT.100700123 DT.92342680 DT.97771863 DT.100637903 DT.120670168 DT.95109036 DT.100733502 DT.99965707

DT.100637738 DT.100647593 DT.100650467 DT.100852063 DT.100647591 DT.100659038 DT.100662630 DT.100847487

24/810 AceView cDNA sequences (see all 810 ):

CA448024 BM875604 BU783553 BM557627 BU620324 BU152865 BX422151 BX428308

BU070050 CR601517 BQ549881 CR607325 AA505883 CR611926 BX090946 BM741105

CR614044 BU070540 AU119302 N99662 R69858 AI083995 CR617238 CR622695

highest scoring ESTs for YWHAH:

AA033522 AA084101 AA084159 AA126874 AA127798 AA134368 AA150478 AA150830 AA155615 AA192540

Unigene Cluster for YWHAH:

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

Hs.226755 [show with all ESTs]

Unigene Representative Sequence: CR622695

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for YWHAH (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:							-		-		-		-
SP2:							-		-				-		-
SP3:							-		-		-		-		-
SP4:							-
SP5:									-		-		-		-

About this scheme

ECgene alternative splicing isoforms for YWHAH

2 Ensembl transcripts including schematic representations:

ENST00000397492 ENST00000248975

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

YWHAH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for YWHAH

¹ / ² / ³

3 probe-sets matching YWHAH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1424_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D78577	0.20	1.00	0.72	1
201020_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003405	0.60	1.00	0.82	1
201020_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCAATCAAGA

SOURCE GeneReport for Unigene cluster: Hs.226755
Expression variation in blood from EXPOLDB for YWHAH
UniProtKB/Swiss-Prot: 1433F_HUMAN, Q04917
Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower
levels

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for YWHAH gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	YWHAH¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	99.46(n) 100(a)	458778 XM_001151357.1 XP_001151357.1
cow (Bos taurus)	YWHAH¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	90.24(n) 98.78(a)	282126 NM_174492.2 NP_776917.2
rat (Rattus norvegicus)	Ywhah¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	92.82(n) 99.19(a)	25576 NM_013052.1 NP_037184.1
mouse (Mus musculus)	Ywhah^{1, 5}	5⁵	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more^{1, 5}	93.22(n)¹ 99.19(a)¹	22629¹ NM_011738.1¹ NP_035868.1¹ AB063260⁵ AB063572⁵ (see all 24)
chicken (Gallus gallus)	YWHAH¹	--	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase more	85.91(n) 97.97(a)	416955 NM_001007839.1 NP_001007840.1

About this table Species with no ortholog for YWHAH

ENSEMBL Gene Tree for YWHAH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for YWHAH gene

YWHAE² YWHAG²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/108 NCBI SNPs in YWHAH are shown (see all 108 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2853887^1,2	A,C,F,H,O	30683894(+)	`CTGTTG/TAACTT`	1	--	ng3¹		13	EA NA EU WA	1142
	rs1049583^1,2	A,C,F,H	30682791(+)	`TTCAGG/ATCCCC`	1	--	ut3¹ ese³		5	MN EU EA WA	594
--	rs11539378^1,2	H	30682368(+)	`ATCAAG/TAACTG`	1	K/N	mis¹		4	EU EA WA	406
--	rs41472548^1,2	F	30683836(+)	`GCCTCG/ACAGAA`	1	--	ng3¹		4	EU EA WA	418
	rs8192635^1,2	H	30682542(+)	`CCCACG/ACATCC`	1	T/T	syn¹ ese³		2	EA	162
	rs933226^1,2	A,C,F,H,O	30673847(+)	`GTGGAT/CATTCA`	1	--	int¹		16	EA NA MN EU WA	1364
	rs2858753^1,2	A,C,F,H,O	30681105(+)	`AACTTC/GCTGCT`	1	--	int¹		17	EU EA WA NA	1550
	rs2853884^1,2	A,C,F,H,O	30678313(+)	`TATTTT/CGGTAT`	1	--	int¹		12	EA NA EU WA	982
	rs2858750^1,2	A,C,F,H,O	30678239(+)	`TCTGTG/ATTGCC`	1	--	int¹		9	EU EA WA NA	956
	rs2246704^1,2	A,C,F,H	30679063(+)	`ATTTGT/CACTCA`	1	--	int¹		8	EU EA WA NA	780

About this table

HapMap Linkage Disequilibrium images for YWHAH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 113508

2 Novoseek disease relationships for YWHAH gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	32.23	2	10206237 (1), 11121172 (1)
tumors	0.00	1	1578511 (1)

About this table

Genetic Association Database: YWHAH
Human Genome Epidemiology Navigator: YWHAH (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/79 PubMed articles for YWHAH gene (see all 79 ):

cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain. (PubMed id 1578511)^{1, 3, 4} Ichimura-Ohshima Y.... Kuwano R. (1992)
The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. (PubMed id 8218406)^{1, 3, 4} Swanson K.D.... Joshi J.G. (1993)
14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia. (PubMed id 10206237)^{1, 3, 6} Toyooka K....Takahashi Y. (1999)
Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia. (PubMed id 11121172)^{1, 3, 6} Bell R....Collier D.A. (2000)
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)^{3, 4} Yoshida K....Miki Y. (2005)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta. (PubMed id 12480176)^{3, 6} Ubl A....Riess O. (2002)
Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. (PubMed id 11266503)^{3, 4} Zilliacus J....Gustafsson J.-A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7533	HGNC: 12853	AceView: YWHAH	Ensembl:ENSG00000128245	euGenes: HUgn7533
ECgene: YWHAH	H-InvDB: YWHAH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for YWHAH	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for YWHAH
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for YWHAH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for YWHAH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for YWHAH		Antibodies for YWHAH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for YWHAH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (YWHAH)
	Antibodies (YWHAH)
	Chimera RNAi (YWHAH)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (14-3-3 eta, 14-3-3 eta + gamma + zeta)
	Antibodies (14-3-3 eta, 14-3-3 eta + gamma + zeta)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for YWHAH

	Drugs/Proteins for YWHAH
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for YWHAH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
YWHAH Gene at Home site.
Version 2.41.1
server5.xennexinc.com

YWHAH Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for YWHAH

Summaries
for YWHAH

Genomic Location
for YWHAH

Proteins
for YWHAH

Protein Domains/
Families
for YWHAH

Gene Function
for YWHAH

Pathways & Interactions
for YWHAH

Drugs & Compounds
for YWHAH

Transcripts
for YWHAH

Expression
for YWHAH

Orthologs
for YWHAH

Paralogs
for YWHAH

SNPs/Variants
for YWHAH

Disorders & Mutations
for YWHAH

Medical News
for YWHAH

Publications
for YWHAH

Search for YWHAH

Genome Databases showing YWHAH

Other Databases showing YWHAH

Specialized Databases showing YWHAH

Licensable Technologies
for YWHAH

Services
for YWHAH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

YWHAH Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor YWHAH

Summariesfor YWHAH

Genomic Locationfor YWHAH

Proteinsfor YWHAH

Protein Domains/Familiesfor YWHAH

Gene Functionfor YWHAH

Pathways & Interactionsfor YWHAH

Drugs & Compoundsfor YWHAH

Transcriptsfor YWHAH

Expression for YWHAH

Orthologsfor YWHAH

Paralogsfor YWHAH

SNPs/Variantsfor YWHAH

Disorders & Mutationsfor YWHAH

Medical Newsfor YWHAH

Publicationsfor YWHAH

Search for YWHAH

Genome Databases showing YWHAH

Other Databases showing YWHAH

Specialized Databases showing YWHAH

Licensable Technologiesfor YWHAH

Servicesfor YWHAH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for YWHAH

Summaries
for YWHAH

Genomic Location
for YWHAH

Proteins
for YWHAH

Protein Domains/
Families
for YWHAH

Gene Function
for YWHAH

Pathways & Interactions
for YWHAH

Drugs & Compounds
for YWHAH

Transcripts
for YWHAH

Expression
for YWHAH

Orthologs
for YWHAH

Paralogs
for YWHAH

SNPs/Variants
for YWHAH

Disorders & Mutations
for YWHAH

Medical News
for YWHAH

Publications
for YWHAH

Licensable Technologies
for YWHAH

Services
for YWHAH